-- dump date   	20140619_054629
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
65393000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
65393000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
65393000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393000004	Walker A motif; other site
65393000005	ATP binding site [chemical binding]; other site
65393000006	Walker B motif; other site
65393000007	arginine finger; other site
65393000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
65393000009	DnaA box-binding interface [nucleotide binding]; other site
65393000010	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
65393000011	UbiA prenyltransferase family; Region: UbiA; pfam01040
65393000012	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
65393000013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
65393000014	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
65393000015	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
65393000016	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
65393000017	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
65393000018	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393000019	putative active site [active]
65393000020	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
65393000021	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
65393000022	Walker A/P-loop; other site
65393000023	ATP binding site [chemical binding]; other site
65393000024	Q-loop/lid; other site
65393000025	ABC transporter signature motif; other site
65393000026	Walker B; other site
65393000027	D-loop; other site
65393000028	H-loop/switch region; other site
65393000029	DevC protein; Region: devC; TIGR01185
65393000030	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
65393000031	FtsX-like permease family; Region: FtsX; pfam02687
65393000032	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
65393000033	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
65393000034	lipoyl-biotinyl attachment site [posttranslational modification]; other site
65393000035	HlyD family secretion protein; Region: HlyD_3; pfam13437
65393000036	Clp protease ATP binding subunit; Region: clpC; CHL00095
65393000037	Clp amino terminal domain; Region: Clp_N; pfam02861
65393000038	Clp amino terminal domain; Region: Clp_N; pfam02861
65393000039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393000040	Walker A motif; other site
65393000041	ATP binding site [chemical binding]; other site
65393000042	Walker B motif; other site
65393000043	arginine finger; other site
65393000044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393000045	Walker A motif; other site
65393000046	ATP binding site [chemical binding]; other site
65393000047	Walker B motif; other site
65393000048	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
65393000049	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
65393000050	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
65393000051	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
65393000052	putative active site [active]
65393000053	putative substrate binding site [chemical binding]; other site
65393000054	putative cosubstrate binding site; other site
65393000055	catalytic site [active]
65393000056	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393000057	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393000058	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
65393000059	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393000060	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
65393000061	protein binding site [polypeptide binding]; other site
65393000062	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393000063	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
65393000064	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393000065	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
65393000066	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
65393000067	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
65393000068	Probable Catalytic site; other site
65393000069	metal-binding site
65393000070	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
65393000071	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
65393000072	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
65393000073	Ligand binding site; other site
65393000074	Putative Catalytic site; other site
65393000075	DXD motif; other site
65393000076	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
65393000077	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65393000078	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
65393000079	Probable Catalytic site; other site
65393000080	metal-binding site
65393000081	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393000082	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
65393000083	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65393000084	active site
65393000085	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
65393000086	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393000087	NAD(P) binding site [chemical binding]; other site
65393000088	active site
65393000089	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
65393000090	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
65393000091	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
65393000092	active site
65393000093	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
65393000094	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
65393000095	feedback inhibition sensing region; other site
65393000096	homohexameric interface [polypeptide binding]; other site
65393000097	nucleotide binding site [chemical binding]; other site
65393000098	N-acetyl-L-glutamate binding site [chemical binding]; other site
65393000099	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
65393000100	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
65393000101	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
65393000102	Low molecular weight phosphatase family; Region: LMWPc; cd00115
65393000103	active site
65393000104	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393000105	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393000106	active site
65393000107	phosphorylation site [posttranslational modification]
65393000108	intermolecular recognition site; other site
65393000109	dimerization interface [polypeptide binding]; other site
65393000110	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393000111	DNA binding residues [nucleotide binding]
65393000112	dimerization interface [polypeptide binding]; other site
65393000113	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
65393000114	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393000115	ATP binding site [chemical binding]; other site
65393000116	putative Mg++ binding site [ion binding]; other site
65393000117	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
65393000118	Ras GTPase Activating Domain; Region: RasGAP; cl02569
65393000119	hypothetical protein; Reviewed; Region: PRK12275
65393000120	four helix bundle protein; Region: TIGR02436
65393000121	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
65393000122	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
65393000123	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393000124	Phytochrome region; Region: PHY; pfam00360
65393000125	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393000126	dimer interface [polypeptide binding]; other site
65393000127	phosphorylation site [posttranslational modification]
65393000128	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393000129	ATP binding site [chemical binding]; other site
65393000130	Mg2+ binding site [ion binding]; other site
65393000131	G-X-G motif; other site
65393000132	Response regulator receiver domain; Region: Response_reg; pfam00072
65393000133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393000134	active site
65393000135	phosphorylation site [posttranslational modification]
65393000136	intermolecular recognition site; other site
65393000137	dimerization interface [polypeptide binding]; other site
65393000138	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393000139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393000140	active site
65393000141	phosphorylation site [posttranslational modification]
65393000142	intermolecular recognition site; other site
65393000143	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393000144	dimerization interface [polypeptide binding]; other site
65393000145	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393000146	dimer interface [polypeptide binding]; other site
65393000147	phosphorylation site [posttranslational modification]
65393000148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393000149	ATP binding site [chemical binding]; other site
65393000150	Mg2+ binding site [ion binding]; other site
65393000151	G-X-G motif; other site
65393000152	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
65393000153	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
65393000154	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
65393000155	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
65393000156	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
65393000157	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65393000158	catalytic residue [active]
65393000159	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
65393000160	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
65393000161	homodimer interface [polypeptide binding]; other site
65393000162	oligonucleotide binding site [chemical binding]; other site
65393000163	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
65393000164	RNA/DNA hybrid binding site [nucleotide binding]; other site
65393000165	active site
65393000166	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
65393000167	prephenate dehydratase; Provisional; Region: PRK11898
65393000168	Prephenate dehydratase; Region: PDT; pfam00800
65393000169	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
65393000170	putative L-Phe binding site [chemical binding]; other site
65393000171	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
65393000172	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
65393000173	elongation factor Tu; Region: tufA; CHL00071
65393000174	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
65393000175	G1 box; other site
65393000176	GEF interaction site [polypeptide binding]; other site
65393000177	GTP/Mg2+ binding site [chemical binding]; other site
65393000178	Switch I region; other site
65393000179	G2 box; other site
65393000180	G3 box; other site
65393000181	Switch II region; other site
65393000182	G4 box; other site
65393000183	G5 box; other site
65393000184	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
65393000185	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
65393000186	Antibiotic Binding Site [chemical binding]; other site
65393000187	elongation factor G; Reviewed; Region: PRK00007
65393000188	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
65393000189	G1 box; other site
65393000190	putative GEF interaction site [polypeptide binding]; other site
65393000191	GTP/Mg2+ binding site [chemical binding]; other site
65393000192	Switch I region; other site
65393000193	G2 box; other site
65393000194	G3 box; other site
65393000195	Switch II region; other site
65393000196	G4 box; other site
65393000197	G5 box; other site
65393000198	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
65393000199	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
65393000200	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
65393000201	30S ribosomal protein S7; Validated; Region: PRK05302
65393000202	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
65393000203	S17 interaction site [polypeptide binding]; other site
65393000204	S8 interaction site; other site
65393000205	16S rRNA interaction site [nucleotide binding]; other site
65393000206	streptomycin interaction site [chemical binding]; other site
65393000207	23S rRNA interaction site [nucleotide binding]; other site
65393000208	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
65393000209	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
65393000210	Cupin domain; Region: Cupin_2; cl17218
65393000211	Probable transposase; Region: OrfB_IS605; pfam01385
65393000212	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
65393000213	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
65393000214	Sulfate transporter family; Region: Sulfate_transp; pfam00916
65393000215	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
65393000216	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393000217	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393000218	ligand binding site [chemical binding]; other site
65393000219	flexible hinge region; other site
65393000220	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
65393000221	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
65393000222	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
65393000223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393000224	dimer interface [polypeptide binding]; other site
65393000225	conserved gate region; other site
65393000226	ABC-ATPase subunit interface; other site
65393000227	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
65393000228	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
65393000229	Walker A/P-loop; other site
65393000230	ATP binding site [chemical binding]; other site
65393000231	Q-loop/lid; other site
65393000232	ABC transporter signature motif; other site
65393000233	Walker B; other site
65393000234	D-loop; other site
65393000235	H-loop/switch region; other site
65393000236	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
65393000237	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
65393000238	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
65393000239	Ligand binding site; other site
65393000240	Putative Catalytic site; other site
65393000241	DXD motif; other site
65393000242	hydrolase, alpha/beta fold family protein; Region: PLN02824
65393000243	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
65393000244	Bacterial Ig-like domain; Region: Big_5; pfam13205
65393000245	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393000246	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393000247	active site
65393000248	ATP binding site [chemical binding]; other site
65393000249	substrate binding site [chemical binding]; other site
65393000250	activation loop (A-loop); other site
65393000251	WD domain, G-beta repeat; Region: WD40; pfam00400
65393000252	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393000253	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393000254	structural tetrad; other site
65393000255	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393000256	structural tetrad; other site
65393000257	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
65393000258	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
65393000259	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393000260	Walker A/P-loop; other site
65393000261	ATP binding site [chemical binding]; other site
65393000262	Q-loop/lid; other site
65393000263	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
65393000264	ABC transporter; Region: ABC_tran_2; pfam12848
65393000265	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
65393000266	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393000267	putative active site [active]
65393000268	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
65393000269	DNA photolyase; Region: DNA_photolyase; pfam00875
65393000270	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393000271	putative active site [active]
65393000272	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
65393000273	dimer interface [polypeptide binding]; other site
65393000274	ADP-ribose binding site [chemical binding]; other site
65393000275	active site
65393000276	nudix motif; other site
65393000277	metal binding site [ion binding]; metal-binding site
65393000278	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
65393000279	catalytic center binding site [active]
65393000280	ATP binding site [chemical binding]; other site
65393000281	AAA domain; Region: AAA_22; pfam13401
65393000282	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393000283	ATP binding site [chemical binding]; other site
65393000284	putative Mg++ binding site [ion binding]; other site
65393000285	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65393000286	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
65393000287	nucleotide binding region [chemical binding]; other site
65393000288	ATP-binding site [chemical binding]; other site
65393000289	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
65393000290	Transposase; Region: DDE_Tnp_ISL3; pfam01610
65393000291	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393000292	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
65393000293	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
65393000294	phosphoglycolate phosphatase; Provisional; Region: PRK01158
65393000295	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393000296	active site
65393000297	motif I; other site
65393000298	motif II; other site
65393000299	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393000300	Probable transposase; Region: OrfB_IS605; pfam01385
65393000301	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393000302	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
65393000303	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
65393000304	dimer interface [polypeptide binding]; other site
65393000305	decamer (pentamer of dimers) interface [polypeptide binding]; other site
65393000306	catalytic triad [active]
65393000307	peroxidatic and resolving cysteines [active]
65393000308	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
65393000309	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
65393000310	active site
65393000311	catalytic site [active]
65393000312	substrate binding site [chemical binding]; other site
65393000313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393000314	AAA domain; Region: AAA_22; pfam13401
65393000315	Walker A motif; other site
65393000316	ATP binding site [chemical binding]; other site
65393000317	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
65393000318	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
65393000319	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
65393000320	putative acyl-acceptor binding pocket; other site
65393000321	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
65393000322	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
65393000323	active site
65393000324	HIGH motif; other site
65393000325	KMSKS motif; other site
65393000326	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
65393000327	anticodon binding site; other site
65393000328	tRNA binding surface [nucleotide binding]; other site
65393000329	Uncharacterized conserved protein [Function unknown]; Region: COG1432
65393000330	LabA_like proteins; Region: LabA; cd10911
65393000331	putative metal binding site [ion binding]; other site
65393000332	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
65393000333	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
65393000334	AAA ATPase domain; Region: AAA_16; pfam13191
65393000335	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393000336	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
65393000337	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
65393000338	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
65393000339	Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641
65393000340	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
65393000341	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
65393000342	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
65393000343	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
65393000344	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
65393000345	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393000346	FeS/SAM binding site; other site
65393000347	TRAM domain; Region: TRAM; pfam01938
65393000348	Photosystem I protein M (PsaM); Region: PsaM; pfam07465
65393000349	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
65393000350	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
65393000351	Transposase; Region: DDE_Tnp_ISL3; pfam01610
65393000352	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393000353	structural tetrad; other site
65393000354	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393000355	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393000356	structural tetrad; other site
65393000357	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
65393000358	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393000359	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
65393000360	putative switch regulator; other site
65393000361	non-specific DNA interactions [nucleotide binding]; other site
65393000362	DNA binding site [nucleotide binding]
65393000363	sequence specific DNA binding site [nucleotide binding]; other site
65393000364	putative cAMP binding site [chemical binding]; other site
65393000365	DALR anticodon binding domain; Region: DALR_1; smart00836
65393000366	anticodon binding site; other site
65393000367	tRNA binding surface [nucleotide binding]; other site
65393000368	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
65393000369	metal-binding site [ion binding]
65393000370	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393000371	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393000372	putative active site [active]
65393000373	heme pocket [chemical binding]; other site
65393000374	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393000375	putative active site [active]
65393000376	heme pocket [chemical binding]; other site
65393000377	PAS domain; Region: PAS_9; pfam13426
65393000378	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393000379	putative active site [active]
65393000380	heme pocket [chemical binding]; other site
65393000381	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393000382	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393000383	PAS fold; Region: PAS_3; pfam08447
65393000384	putative active site [active]
65393000385	heme pocket [chemical binding]; other site
65393000386	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393000387	PAS fold; Region: PAS_3; pfam08447
65393000388	putative active site [active]
65393000389	heme pocket [chemical binding]; other site
65393000390	PAS domain S-box; Region: sensory_box; TIGR00229
65393000391	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393000392	putative active site [active]
65393000393	heme pocket [chemical binding]; other site
65393000394	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393000395	PAS fold; Region: PAS_3; pfam08447
65393000396	putative active site [active]
65393000397	heme pocket [chemical binding]; other site
65393000398	PAS domain S-box; Region: sensory_box; TIGR00229
65393000399	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393000400	putative active site [active]
65393000401	heme pocket [chemical binding]; other site
65393000402	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393000403	dimer interface [polypeptide binding]; other site
65393000404	phosphorylation site [posttranslational modification]
65393000405	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393000406	ATP binding site [chemical binding]; other site
65393000407	Mg2+ binding site [ion binding]; other site
65393000408	G-X-G motif; other site
65393000409	Response regulator receiver domain; Region: Response_reg; pfam00072
65393000410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393000411	active site
65393000412	phosphorylation site [posttranslational modification]
65393000413	intermolecular recognition site; other site
65393000414	dimerization interface [polypeptide binding]; other site
65393000415	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
65393000416	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
65393000417	active site
65393000418	catalytic triad [active]
65393000419	Predicted ATPase [General function prediction only]; Region: COG4637
65393000420	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393000421	Walker A/P-loop; other site
65393000422	ATP binding site [chemical binding]; other site
65393000423	SOUL heme-binding protein; Region: SOUL; pfam04832
65393000424	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
65393000425	endonuclease III; Region: ENDO3c; smart00478
65393000426	minor groove reading motif; other site
65393000427	helix-hairpin-helix signature motif; other site
65393000428	substrate binding pocket [chemical binding]; other site
65393000429	active site
65393000430	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
65393000431	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
65393000432	active site
65393000433	metal binding site [ion binding]; metal-binding site
65393000434	interdomain interaction site; other site
65393000435	Virulence-associated protein E; Region: VirE; pfam05272
65393000436	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
65393000437	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
65393000438	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
65393000439	active site
65393000440	catalytic residues [active]
65393000441	DNA binding site [nucleotide binding]
65393000442	Int/Topo IB signature motif; other site
65393000443	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
65393000444	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
65393000445	Fn3 associated; Region: Fn3_assoc; pfam13287
65393000446	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
65393000447	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
65393000448	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
65393000449	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
65393000450	active site
65393000451	catalytic site [active]
65393000452	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
65393000453	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
65393000454	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
65393000455	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
65393000456	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
65393000457	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
65393000458	plastocyanin; Provisional; Region: PRK02710
65393000459	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
65393000460	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
65393000461	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393000462	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
65393000463	HEAT repeats; Region: HEAT_2; pfam13646
65393000464	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
65393000465	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
65393000466	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65393000467	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
65393000468	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65393000469	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
65393000470	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
65393000471	Phycobilisome protein; Region: Phycobilisome; cl08227
65393000472	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
65393000473	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
65393000474	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393000475	S-adenosylmethionine binding site [chemical binding]; other site
65393000476	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393000477	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393000478	active site
65393000479	phosphorylation site [posttranslational modification]
65393000480	intermolecular recognition site; other site
65393000481	dimerization interface [polypeptide binding]; other site
65393000482	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393000483	DNA binding residues [nucleotide binding]
65393000484	dimerization interface [polypeptide binding]; other site
65393000485	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
65393000486	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
65393000487	NAD(P) binding site [chemical binding]; other site
65393000488	catalytic residues [active]
65393000489	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
65393000490	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
65393000491	intersubunit interface [polypeptide binding]; other site
65393000492	active site
65393000493	zinc binding site [ion binding]; other site
65393000494	Na+ binding site [ion binding]; other site
65393000495	Haemolysin XhlA; Region: XhlA; pfam10779
65393000496	5'-AMP-activated protein kinase beta subunit, interation domain; Region: AMPKBI; cl08426
65393000497	tellurium resistance terB-like protein; Region: terB_like; cl11965
65393000498	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
65393000499	protein I interface; other site
65393000500	D2 interface; other site
65393000501	protein T interface; other site
65393000502	chlorophyll binding site; other site
65393000503	beta carotene binding site; other site
65393000504	pheophytin binding site; other site
65393000505	manganese-stabilizing polypeptide interface; other site
65393000506	CP43 interface; other site
65393000507	protein L interface; other site
65393000508	oxygen evolving complex binding site; other site
65393000509	bromide binding site; other site
65393000510	quinone binding site; other site
65393000511	Fe binding site [ion binding]; other site
65393000512	core light harvesting interface; other site
65393000513	cytochrome b559 alpha subunit interface; other site
65393000514	cytochrome c-550 interface; other site
65393000515	protein J interface; other site
65393000516	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393000517	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
65393000518	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
65393000519	nucleotide binding site [chemical binding]; other site
65393000520	putative NEF/HSP70 interaction site [polypeptide binding]; other site
65393000521	SBD interface [polypeptide binding]; other site
65393000522	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393000523	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393000524	Probable transposase; Region: OrfB_IS605; pfam01385
65393000525	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65393000526	TPR repeat; Region: TPR_11; pfam13414
65393000527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393000528	binding surface
65393000529	TPR motif; other site
65393000530	TPR repeat; Region: TPR_11; pfam13414
65393000531	amino acid transporter; Region: 2A0306; TIGR00909
65393000532	Response regulator receiver domain; Region: Response_reg; pfam00072
65393000533	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393000534	active site
65393000535	phosphorylation site [posttranslational modification]
65393000536	intermolecular recognition site; other site
65393000537	dimerization interface [polypeptide binding]; other site
65393000538	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393000539	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393000540	metal binding site [ion binding]; metal-binding site
65393000541	active site
65393000542	I-site; other site
65393000543	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
65393000544	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
65393000545	substrate binding pocket [chemical binding]; other site
65393000546	membrane-bound complex binding site; other site
65393000547	hinge residues; other site
65393000548	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393000549	binding surface
65393000550	TPR motif; other site
65393000551	TPR repeat; Region: TPR_11; pfam13414
65393000552	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
65393000553	putative substrate binding pocket [chemical binding]; other site
65393000554	catalytic triad [active]
65393000555	AB domain interface; other site
65393000556	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
65393000557	dimerization interface [polypeptide binding]; other site
65393000558	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
65393000559	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
65393000560	active site
65393000561	NTP binding site [chemical binding]; other site
65393000562	metal binding triad [ion binding]; metal-binding site
65393000563	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
65393000564	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
65393000565	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
65393000566	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
65393000567	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
65393000568	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
65393000569	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
65393000570	Sporulation and spore germination; Region: Germane; pfam10646
65393000571	EVE domain; Region: EVE; cl00728
65393000572	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
65393000573	homodimer interface [polypeptide binding]; other site
65393000574	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
65393000575	active site pocket [active]
65393000576	thiamine monophosphate kinase; Provisional; Region: PRK05731
65393000577	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
65393000578	ATP binding site [chemical binding]; other site
65393000579	dimerization interface [polypeptide binding]; other site
65393000580	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65393000581	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
65393000582	active site
65393000583	catalytic tetrad [active]
65393000584	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65393000585	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65393000586	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
65393000587	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
65393000588	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
65393000589	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
65393000590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393000591	putative substrate translocation pore; other site
65393000592	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
65393000593	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65393000594	active site
65393000595	Response regulator receiver domain; Region: Response_reg; pfam00072
65393000596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393000597	active site
65393000598	phosphorylation site [posttranslational modification]
65393000599	intermolecular recognition site; other site
65393000600	dimerization interface [polypeptide binding]; other site
65393000601	Circadian oscillating protein COP23; Region: COP23; pfam14218
65393000602	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393000603	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393000604	active site
65393000605	ATP binding site [chemical binding]; other site
65393000606	substrate binding site [chemical binding]; other site
65393000607	activation loop (A-loop); other site
65393000608	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
65393000609	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393000610	active site
65393000611	ATP binding site [chemical binding]; other site
65393000612	substrate binding site [chemical binding]; other site
65393000613	activation loop (A-loop); other site
65393000614	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393000615	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393000616	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393000617	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
65393000618	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
65393000619	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
65393000620	domain interfaces; other site
65393000621	active site
65393000622	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393000623	putative active site [active]
65393000624	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
65393000625	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
65393000626	Cl- selectivity filter; other site
65393000627	Cl- binding residues [ion binding]; other site
65393000628	pore gating glutamate residue; other site
65393000629	dimer interface [polypeptide binding]; other site
65393000630	H+/Cl- coupling transport residue; other site
65393000631	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
65393000632	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
65393000633	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
65393000634	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
65393000635	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65393000636	Soluble P-type ATPase [General function prediction only]; Region: COG4087
65393000637	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
65393000638	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393000639	NAD(P) binding site [chemical binding]; other site
65393000640	active site
65393000641	EcsC protein family; Region: EcsC; pfam12787
65393000642	putative lipid kinase; Reviewed; Region: PRK00861
65393000643	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
65393000644	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
65393000645	GTP-binding protein YchF; Reviewed; Region: PRK09601
65393000646	YchF GTPase; Region: YchF; cd01900
65393000647	G1 box; other site
65393000648	GTP/Mg2+ binding site [chemical binding]; other site
65393000649	Switch I region; other site
65393000650	G2 box; other site
65393000651	Switch II region; other site
65393000652	G3 box; other site
65393000653	G4 box; other site
65393000654	G5 box; other site
65393000655	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
65393000656	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
65393000657	Esterase/lipase [General function prediction only]; Region: COG1647
65393000658	cytosine deaminase-like protein; Validated; Region: PRK07583
65393000659	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
65393000660	active site
65393000661	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
65393000662	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
65393000663	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
65393000664	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
65393000665	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
65393000666	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
65393000667	AAA domain; Region: AAA_31; pfam13614
65393000668	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65393000669	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
65393000670	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65393000671	active site
65393000672	catalytic tetrad [active]
65393000673	Bifunctional nuclease; Region: DNase-RNase; pfam02577
65393000674	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
65393000675	Lumazine binding domain; Region: Lum_binding; pfam00677
65393000676	Lumazine binding domain; Region: Lum_binding; pfam00677
65393000677	Uncharacterized conserved protein [Function unknown]; Region: COG3379
65393000678	Uncharacterized conserved protein [Function unknown]; Region: COG3379
65393000679	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
65393000680	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393000681	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393000682	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393000683	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393000684	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
65393000685	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65393000686	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
65393000687	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
65393000688	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
65393000689	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
65393000690	Protein of unknown function (DUF552); Region: DUF552; pfam04472
65393000691	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
65393000692	NADPH bind site [chemical binding]; other site
65393000693	putative FMN binding site [chemical binding]; other site
65393000694	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
65393000695	putative FMN binding site [chemical binding]; other site
65393000696	NADPH bind site [chemical binding]; other site
65393000697	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393000698	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
65393000699	Uncharacterized conserved protein [Function unknown]; Region: COG2361
65393000700	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65393000701	active site
65393000702	NTP binding site [chemical binding]; other site
65393000703	metal binding triad [ion binding]; metal-binding site
65393000704	antibiotic binding site [chemical binding]; other site
65393000705	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
65393000706	Protein of unknown function (DUF433); Region: DUF433; pfam04255
65393000707	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
65393000708	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
65393000709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
65393000710	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
65393000711	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
65393000712	putative substrate binding site [chemical binding]; other site
65393000713	putative ATP binding site [chemical binding]; other site
65393000714	ADP-glucose phosphorylase; Region: PLN02643
65393000715	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
65393000716	nucleotide binding site/active site [active]
65393000717	HIT family signature motif; other site
65393000718	catalytic residue [active]
65393000719	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
65393000720	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
65393000721	generic binding surface II; other site
65393000722	generic binding surface I; other site
65393000723	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
65393000724	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393000725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393000726	S-adenosylmethionine binding site [chemical binding]; other site
65393000727	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
65393000728	putative active site [active]
65393000729	putative metal binding site [ion binding]; other site
65393000730	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
65393000731	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
65393000732	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
65393000733	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
65393000734	Protein of unknown function, DUF608; Region: DUF608; pfam04685
65393000735	Stage II sporulation protein; Region: SpoIID; pfam08486
65393000736	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
65393000737	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
65393000738	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
65393000739	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
65393000740	inhibitor-cofactor binding pocket; inhibition site
65393000741	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393000742	catalytic residue [active]
65393000743	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65393000744	Protein of unknown function (DUF561); Region: DUF561; pfam04481
65393000745	homoserine dehydrogenase; Provisional; Region: PRK06349
65393000746	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
65393000747	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
65393000748	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
65393000749	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
65393000750	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
65393000751	Peptidase family M23; Region: Peptidase_M23; pfam01551
65393000752	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65393000753	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393000754	S-adenosylmethionine binding site [chemical binding]; other site
65393000755	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
65393000756	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
65393000757	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
65393000758	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
65393000759	NAD synthetase; Provisional; Region: PRK13981
65393000760	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
65393000761	multimer interface [polypeptide binding]; other site
65393000762	active site
65393000763	catalytic triad [active]
65393000764	protein interface 1 [polypeptide binding]; other site
65393000765	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
65393000766	homodimer interface [polypeptide binding]; other site
65393000767	NAD binding pocket [chemical binding]; other site
65393000768	ATP binding pocket [chemical binding]; other site
65393000769	Mg binding site [ion binding]; other site
65393000770	active-site loop [active]
65393000771	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
65393000772	nudix motif; other site
65393000773	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
65393000774	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
65393000775	active site
65393000776	(T/H)XGH motif; other site
65393000777	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
65393000778	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
65393000779	active site
65393000780	Uncharacterized conserved protein [Function unknown]; Region: COG2361
65393000781	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65393000782	active site
65393000783	NTP binding site [chemical binding]; other site
65393000784	metal binding triad [ion binding]; metal-binding site
65393000785	antibiotic binding site [chemical binding]; other site
65393000786	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
65393000787	Domain of unknown function (DUF389); Region: DUF389; pfam04087
65393000788	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
65393000789	CoA binding domain; Region: CoA_binding; pfam02629
65393000790	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
65393000791	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
65393000792	short chain dehydrogenase; Validated; Region: PRK06182
65393000793	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
65393000794	NADP binding site [chemical binding]; other site
65393000795	active site
65393000796	steroid binding site; other site
65393000797	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
65393000798	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
65393000799	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65393000800	active site
65393000801	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
65393000802	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
65393000803	tetramer interface [polypeptide binding]; other site
65393000804	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393000805	catalytic residue [active]
65393000806	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
65393000807	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393000808	motif II; other site
65393000809	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
65393000810	intersubunit interface [polypeptide binding]; other site
65393000811	active site
65393000812	Zn2+ binding site [ion binding]; other site
65393000813	Bifunctional nuclease; Region: DNase-RNase; pfam02577
65393000814	dihydrodipicolinate reductase; Provisional; Region: PRK00048
65393000815	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
65393000816	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
65393000817	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
65393000818	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
65393000819	isocitrate dehydrogenase; Validated; Region: PRK07362
65393000820	quinolinate synthetase; Provisional; Region: PRK09375
65393000821	short chain dehydrogenase; Provisional; Region: PRK07063
65393000822	classical (c) SDRs; Region: SDR_c; cd05233
65393000823	NAD(P) binding site [chemical binding]; other site
65393000824	active site
65393000825	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
65393000826	Beta-lactamase; Region: Beta-lactamase; pfam00144
65393000827	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393000828	putative active site [active]
65393000829	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
65393000830	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393000831	ATP binding site [chemical binding]; other site
65393000832	putative Mg++ binding site [ion binding]; other site
65393000833	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65393000834	nucleotide binding region [chemical binding]; other site
65393000835	ATP-binding site [chemical binding]; other site
65393000836	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
65393000837	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
65393000838	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
65393000839	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
65393000840	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
65393000841	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
65393000842	Walker A/P-loop; other site
65393000843	ATP binding site [chemical binding]; other site
65393000844	Q-loop/lid; other site
65393000845	ABC transporter signature motif; other site
65393000846	Walker B; other site
65393000847	D-loop; other site
65393000848	H-loop/switch region; other site
65393000849	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
65393000850	putative carbohydrate binding site [chemical binding]; other site
65393000851	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393000852	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393000853	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
65393000854	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65393000855	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65393000856	active site
65393000857	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65393000858	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65393000859	active site
65393000860	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
65393000861	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65393000862	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
65393000863	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
65393000864	RNase_H superfamily; Region: RNase_H_2; pfam13482
65393000865	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
65393000866	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
65393000867	peptide binding site [polypeptide binding]; other site
65393000868	dimer interface [polypeptide binding]; other site
65393000869	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
65393000870	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
65393000871	putative ribose interaction site [chemical binding]; other site
65393000872	putative ADP binding site [chemical binding]; other site
65393000873	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
65393000874	DNA polymerase III subunit beta; Validated; Region: PRK05643
65393000875	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
65393000876	putative DNA binding surface [nucleotide binding]; other site
65393000877	dimer interface [polypeptide binding]; other site
65393000878	beta-clamp/clamp loader binding surface; other site
65393000879	beta-clamp/translesion DNA polymerase binding surface; other site
65393000880	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393000881	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393000882	active site
65393000883	ATP binding site [chemical binding]; other site
65393000884	substrate binding site [chemical binding]; other site
65393000885	activation loop (A-loop); other site
65393000886	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
65393000887	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
65393000888	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
65393000889	putative dimerization interface [polypeptide binding]; other site
65393000890	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
65393000891	DNA photolyase; Region: DNA_photolyase; pfam00875
65393000892	Protein of unknown function (DUF938); Region: DUF938; pfam06080
65393000893	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
65393000894	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
65393000895	dimer interface [polypeptide binding]; other site
65393000896	putative anticodon binding site; other site
65393000897	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
65393000898	motif 1; other site
65393000899	active site
65393000900	motif 2; other site
65393000901	motif 3; other site
65393000902	KTSC domain; Region: KTSC; pfam13619
65393000903	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
65393000904	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65393000905	non-specific DNA binding site [nucleotide binding]; other site
65393000906	salt bridge; other site
65393000907	sequence-specific DNA binding site [nucleotide binding]; other site
65393000908	PBP superfamily domain; Region: PBP_like; pfam12727
65393000909	Response regulator receiver domain; Region: Response_reg; pfam00072
65393000910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393000911	active site
65393000912	phosphorylation site [posttranslational modification]
65393000913	intermolecular recognition site; other site
65393000914	dimerization interface [polypeptide binding]; other site
65393000915	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
65393000916	FAD binding site [chemical binding]; other site
65393000917	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
65393000918	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
65393000919	active site
65393000920	HIGH motif; other site
65393000921	dimer interface [polypeptide binding]; other site
65393000922	KMSKS motif; other site
65393000923	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
65393000924	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
65393000925	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
65393000926	Protein of unknown function (DUF565); Region: DUF565; pfam04483
65393000927	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
65393000928	PRC-barrel domain; Region: PRC; pfam05239
65393000929	PRC-barrel domain; Region: PRC; pfam05239
65393000930	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
65393000931	active site
65393000932	dimerization interface [polypeptide binding]; other site
65393000933	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
65393000934	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
65393000935	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
65393000936	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
65393000937	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
65393000938	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
65393000939	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
65393000940	active site
65393000941	photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049
65393000942	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393000943	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65393000944	phosphopeptide binding site; other site
65393000945	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
65393000946	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
65393000947	argininosuccinate synthase; Provisional; Region: PRK13820
65393000948	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
65393000949	ANP binding site [chemical binding]; other site
65393000950	Substrate Binding Site II [chemical binding]; other site
65393000951	Substrate Binding Site I [chemical binding]; other site
65393000952	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
65393000953	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393000954	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
65393000955	ligand binding site [chemical binding]; other site
65393000956	flexible hinge region; other site
65393000957	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
65393000958	putative switch regulator; other site
65393000959	non-specific DNA interactions [nucleotide binding]; other site
65393000960	DNA binding site [nucleotide binding]
65393000961	sequence specific DNA binding site [nucleotide binding]; other site
65393000962	putative cAMP binding site [chemical binding]; other site
65393000963	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
65393000964	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
65393000965	NAD binding site [chemical binding]; other site
65393000966	homotetramer interface [polypeptide binding]; other site
65393000967	homodimer interface [polypeptide binding]; other site
65393000968	substrate binding site [chemical binding]; other site
65393000969	active site
65393000970	Protein of unknown function (DUF98); Region: DUF98; pfam01947
65393000971	Predicted membrane protein [Function unknown]; Region: COG1950
65393000972	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
65393000973	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
65393000974	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
65393000975	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
65393000976	active site
65393000977	SAM binding site [chemical binding]; other site
65393000978	homodimer interface [polypeptide binding]; other site
65393000979	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
65393000980	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
65393000981	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
65393000982	Multicopper oxidase; Region: Cu-oxidase; pfam00394
65393000983	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
65393000984	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
65393000985	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
65393000986	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393000987	S-adenosylmethionine binding site [chemical binding]; other site
65393000988	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65393000989	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393000990	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
65393000991	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
65393000992	B12 binding site [chemical binding]; other site
65393000993	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393000994	FeS/SAM binding site; other site
65393000995	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
65393000996	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
65393000997	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
65393000998	anti sigma factor interaction site; other site
65393000999	regulatory phosphorylation site [posttranslational modification]; other site
65393001000	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
65393001001	nucleotide binding site/active site [active]
65393001002	HIT family signature motif; other site
65393001003	catalytic residue [active]
65393001004	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
65393001005	catalytic motif [active]
65393001006	Catalytic residue [active]
65393001007	L-aspartate oxidase; Provisional; Region: PRK07395
65393001008	L-aspartate oxidase; Provisional; Region: PRK06175
65393001009	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
65393001010	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65393001011	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393001012	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393001013	Probable transposase; Region: OrfB_IS605; pfam01385
65393001014	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393001015	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
65393001016	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
65393001017	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
65393001018	dimer interface [polypeptide binding]; other site
65393001019	decamer (pentamer of dimers) interface [polypeptide binding]; other site
65393001020	catalytic triad [active]
65393001021	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
65393001022	generic binding surface II; other site
65393001023	generic binding surface I; other site
65393001024	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
65393001025	putative active site [active]
65393001026	putative catalytic site [active]
65393001027	putative Mg binding site IVb [ion binding]; other site
65393001028	putative phosphate binding site [ion binding]; other site
65393001029	putative DNA binding site [nucleotide binding]; other site
65393001030	putative Mg binding site IVa [ion binding]; other site
65393001031	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
65393001032	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
65393001033	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
65393001034	Apolipophorin-III precursor (apoLp-III); Region: ApoLp-III; pfam07464
65393001035	TPR repeat; Region: TPR_11; pfam13414
65393001036	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393001037	binding surface
65393001038	TPR motif; other site
65393001039	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
65393001040	photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200
65393001041	Homeodomain-like domain; Region: HTH_23; pfam13384
65393001042	Winged helix-turn helix; Region: HTH_29; pfam13551
65393001043	Winged helix-turn helix; Region: HTH_33; pfam13592
65393001044	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393001045	ligand binding site [chemical binding]; other site
65393001046	flexible hinge region; other site
65393001047	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
65393001048	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
65393001049	putative active site [active]
65393001050	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393001051	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393001052	Walker A/P-loop; other site
65393001053	ATP binding site [chemical binding]; other site
65393001054	Q-loop/lid; other site
65393001055	ABC transporter signature motif; other site
65393001056	Walker B; other site
65393001057	D-loop; other site
65393001058	H-loop/switch region; other site
65393001059	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
65393001060	HlyD family secretion protein; Region: HlyD_3; pfam13437
65393001061	SurA N-terminal domain; Region: SurA_N_3; cl07813
65393001062	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
65393001063	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
65393001064	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
65393001065	oligomeric interface; other site
65393001066	putative active site [active]
65393001067	homodimer interface [polypeptide binding]; other site
65393001068	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393001069	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393001070	TPR motif; other site
65393001071	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393001072	binding surface
65393001073	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393001074	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393001075	binding surface
65393001076	TPR motif; other site
65393001077	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393001078	shikimate kinase II; Reviewed; Region: aroL; cl17327
65393001079	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
65393001080	Phosphotransferase enzyme family; Region: APH; pfam01636
65393001081	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
65393001082	active site
65393001083	ATP binding site [chemical binding]; other site
65393001084	nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103
65393001085	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393001086	FeS/SAM binding site; other site
65393001087	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
65393001088	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
65393001089	TPR repeat; Region: TPR_11; pfam13414
65393001090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393001091	binding surface
65393001092	TPR motif; other site
65393001093	TPR repeat; Region: TPR_11; pfam13414
65393001094	TPR repeat; Region: TPR_11; pfam13414
65393001095	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
65393001096	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
65393001097	putative active site pocket [active]
65393001098	4-fold oligomerization interface [polypeptide binding]; other site
65393001099	metal binding residues [ion binding]; metal-binding site
65393001100	3-fold/trimer interface [polypeptide binding]; other site
65393001101	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
65393001102	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
65393001103	active site
65393001104	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
65393001105	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
65393001106	CheB methylesterase; Region: CheB_methylest; pfam01339
65393001107	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
65393001108	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
65393001109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393001110	S-adenosylmethionine binding site [chemical binding]; other site
65393001111	PAS domain; Region: PAS_9; pfam13426
65393001112	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001113	PAS domain; Region: PAS_9; pfam13426
65393001114	putative active site [active]
65393001115	heme pocket [chemical binding]; other site
65393001116	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001117	PAS domain; Region: PAS_9; pfam13426
65393001118	putative active site [active]
65393001119	heme pocket [chemical binding]; other site
65393001120	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
65393001121	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001122	putative active site [active]
65393001123	heme pocket [chemical binding]; other site
65393001124	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393001125	dimer interface [polypeptide binding]; other site
65393001126	phosphorylation site [posttranslational modification]
65393001127	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393001128	ATP binding site [chemical binding]; other site
65393001129	Mg2+ binding site [ion binding]; other site
65393001130	G-X-G motif; other site
65393001131	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393001132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393001133	active site
65393001134	phosphorylation site [posttranslational modification]
65393001135	intermolecular recognition site; other site
65393001136	dimerization interface [polypeptide binding]; other site
65393001137	aspartate aminotransferase; Provisional; Region: PRK05957
65393001138	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65393001139	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393001140	homodimer interface [polypeptide binding]; other site
65393001141	catalytic residue [active]
65393001142	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001143	PAS domain; Region: PAS_9; pfam13426
65393001144	putative active site [active]
65393001145	heme pocket [chemical binding]; other site
65393001146	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393001147	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393001148	ligand binding site [chemical binding]; other site
65393001149	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
65393001150	putative switch regulator; other site
65393001151	non-specific DNA interactions [nucleotide binding]; other site
65393001152	DNA binding site [nucleotide binding]
65393001153	sequence specific DNA binding site [nucleotide binding]; other site
65393001154	putative cAMP binding site [chemical binding]; other site
65393001155	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
65393001156	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
65393001157	acyl-activating enzyme (AAE) consensus motif; other site
65393001158	putative AMP binding site [chemical binding]; other site
65393001159	putative active site [active]
65393001160	putative CoA binding site [chemical binding]; other site
65393001161	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
65393001162	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
65393001163	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393001164	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
65393001165	NAD(P) binding site [chemical binding]; other site
65393001166	active site
65393001167	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
65393001168	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
65393001169	E3 interaction surface; other site
65393001170	lipoyl attachment site [posttranslational modification]; other site
65393001171	e3 binding domain; Region: E3_binding; pfam02817
65393001172	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
65393001173	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393001174	Probable transposase; Region: OrfB_IS605; pfam01385
65393001175	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393001176	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65393001177	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
65393001178	Protein of unknown function; Region: DUF3971; pfam13116
65393001179	Family of unknown function (DUF490); Region: DUF490; pfam04357
65393001180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393001181	BT1 family; Region: BT1; pfam03092
65393001182	putative substrate translocation pore; other site
65393001183	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
65393001184	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
65393001185	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
65393001186	putative ADP-ribose binding site [chemical binding]; other site
65393001187	putative active site [active]
65393001188	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
65393001189	glutaminase; Provisional; Region: PRK00971
65393001190	Uncharacterized conserved protein [Function unknown]; Region: COG1434
65393001191	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
65393001192	putative active site [active]
65393001193	HAS barrel domain; Region: HAS-barrel; pfam09378
65393001194	HerA helicase [Replication, recombination, and repair]; Region: COG0433
65393001195	Domain of unknown function DUF87; Region: DUF87; pfam01935
65393001196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393001197	binding surface
65393001198	TPR repeat; Region: TPR_11; pfam13414
65393001199	TPR motif; other site
65393001200	TPR repeat; Region: TPR_11; pfam13414
65393001201	TPR repeat; Region: TPR_11; pfam13414
65393001202	Tetratricopeptide repeat; Region: TPR_1; pfam00515
65393001203	TPR repeat; Region: TPR_11; pfam13414
65393001204	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393001205	binding surface
65393001206	TPR motif; other site
65393001207	TPR repeat; Region: TPR_11; pfam13414
65393001208	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393001209	binding surface
65393001210	TPR motif; other site
65393001211	TPR repeat; Region: TPR_11; pfam13414
65393001212	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
65393001213	Nitrogen regulatory protein P-II; Region: P-II; smart00938
65393001214	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
65393001215	active site
65393001216	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
65393001217	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
65393001218	putative acyl-acceptor binding pocket; other site
65393001219	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
65393001220	catalytic residues [active]
65393001221	Predicted membrane protein [Function unknown]; Region: COG4094
65393001222	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
65393001223	metal binding site 2 [ion binding]; metal-binding site
65393001224	putative DNA binding helix; other site
65393001225	metal binding site 1 [ion binding]; metal-binding site
65393001226	dimer interface [polypeptide binding]; other site
65393001227	structural Zn2+ binding site [ion binding]; other site
65393001228	Response regulator receiver domain; Region: Response_reg; pfam00072
65393001229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393001230	active site
65393001231	phosphorylation site [posttranslational modification]
65393001232	intermolecular recognition site; other site
65393001233	dimerization interface [polypeptide binding]; other site
65393001234	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
65393001235	cell division protein; Validated; Region: ftsH; CHL00176
65393001236	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393001237	Walker A motif; other site
65393001238	ATP binding site [chemical binding]; other site
65393001239	Walker B motif; other site
65393001240	arginine finger; other site
65393001241	Peptidase family M41; Region: Peptidase_M41; pfam01434
65393001242	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393001243	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393001244	active site
65393001245	ATP binding site [chemical binding]; other site
65393001246	substrate binding site [chemical binding]; other site
65393001247	activation loop (A-loop); other site
65393001248	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
65393001249	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
65393001250	Mg++ binding site [ion binding]; other site
65393001251	putative catalytic motif [active]
65393001252	putative substrate binding site [chemical binding]; other site
65393001253	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
65393001254	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
65393001255	putative active site [active]
65393001256	substrate binding site [chemical binding]; other site
65393001257	redox center [active]
65393001258	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
65393001259	Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434
65393001260	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
65393001261	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
65393001262	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393001263	FeS/SAM binding site; other site
65393001264	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
65393001265	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
65393001266	ligand binding site; other site
65393001267	oligomer interface; other site
65393001268	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
65393001269	dimer interface [polypeptide binding]; other site
65393001270	N-terminal domain interface [polypeptide binding]; other site
65393001271	sulfate 1 binding site; other site
65393001272	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
65393001273	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
65393001274	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
65393001275	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
65393001276	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
65393001277	active site
65393001278	Zn binding site [ion binding]; other site
65393001279	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
65393001280	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393001281	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
65393001282	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
65393001283	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
65393001284	active site
65393001285	substrate binding site [chemical binding]; other site
65393001286	cosubstrate binding site; other site
65393001287	catalytic site [active]
65393001288	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
65393001289	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
65393001290	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
65393001291	Predicted membrane protein [Function unknown]; Region: COG3431
65393001292	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
65393001293	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
65393001294	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
65393001295	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
65393001296	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
65393001297	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
65393001298	ATP-grasp domain; Region: ATP-grasp_4; cl17255
65393001299	Predicted membrane protein [Function unknown]; Region: COG4330
65393001300	TspO/MBR family; Region: TspO_MBR; cl01379
65393001301	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
65393001302	classical (c) SDRs; Region: SDR_c; cd05233
65393001303	NAD(P) binding site [chemical binding]; other site
65393001304	active site
65393001305	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
65393001306	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
65393001307	oligomer interface [polypeptide binding]; other site
65393001308	metal binding site [ion binding]; metal-binding site
65393001309	metal binding site [ion binding]; metal-binding site
65393001310	Cl binding site [ion binding]; other site
65393001311	aspartate ring; other site
65393001312	basic sphincter; other site
65393001313	putative hydrophobic gate; other site
65393001314	periplasmic entrance; other site
65393001315	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393001316	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
65393001317	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
65393001318	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
65393001319	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
65393001320	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
65393001321	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393001322	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
65393001323	dimer interface [polypeptide binding]; other site
65393001324	phosphorylation site [posttranslational modification]
65393001325	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393001326	ATP binding site [chemical binding]; other site
65393001327	Mg2+ binding site [ion binding]; other site
65393001328	G-X-G motif; other site
65393001329	putative acyltransferase; Provisional; Region: PRK05790
65393001330	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
65393001331	dimer interface [polypeptide binding]; other site
65393001332	active site
65393001333	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
65393001334	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393001335	NAD(P) binding site [chemical binding]; other site
65393001336	active site
65393001337	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914
65393001338	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
65393001339	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
65393001340	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
65393001341	catalytic motif [active]
65393001342	Zn binding site [ion binding]; other site
65393001343	RibD C-terminal domain; Region: RibD_C; cl17279
65393001344	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
65393001345	Response regulator receiver domain; Region: Response_reg; pfam00072
65393001346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393001347	active site
65393001348	phosphorylation site [posttranslational modification]
65393001349	intermolecular recognition site; other site
65393001350	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393001351	dimerization interface [polypeptide binding]; other site
65393001352	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
65393001353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393001354	ATP binding site [chemical binding]; other site
65393001355	Mg2+ binding site [ion binding]; other site
65393001356	G-X-G motif; other site
65393001357	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
65393001358	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393001359	hydroxyglutarate oxidase; Provisional; Region: PRK11728
65393001360	Stage II sporulation protein; Region: SpoIID; pfam08486
65393001361	Homeodomain-like domain; Region: HTH_23; pfam13384
65393001362	Uncharacterized conserved protein [Function unknown]; Region: COG3937
65393001363	peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516
65393001364	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
65393001365	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
65393001366	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
65393001367	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65393001368	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393001369	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
65393001370	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
65393001371	dimer interface [polypeptide binding]; other site
65393001372	motif 1; other site
65393001373	active site
65393001374	motif 2; other site
65393001375	motif 3; other site
65393001376	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
65393001377	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65393001378	HSP70 interaction site [polypeptide binding]; other site
65393001379	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393001380	TPR repeat; Region: TPR_11; pfam13414
65393001381	binding surface
65393001382	TPR motif; other site
65393001383	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
65393001384	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
65393001385	active site
65393001386	dimerization interface [polypeptide binding]; other site
65393001387	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65393001388	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65393001389	catalytic loop [active]
65393001390	iron binding site [ion binding]; other site
65393001391	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
65393001392	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
65393001393	CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905
65393001394	ChaB; Region: ChaB; pfam06150
65393001395	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
65393001396	classical (c) SDRs; Region: SDR_c; cd05233
65393001397	NAD(P) binding site [chemical binding]; other site
65393001398	active site
65393001399	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
65393001400	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
65393001401	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
65393001402	trimer interface [polypeptide binding]; other site
65393001403	active site
65393001404	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
65393001405	catalytic site [active]
65393001406	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
65393001407	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
65393001408	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
65393001409	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
65393001410	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
65393001411	active site
65393001412	Substrate binding site; other site
65393001413	Mg++ binding site; other site
65393001414	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
65393001415	putative trimer interface [polypeptide binding]; other site
65393001416	putative CoA binding site [chemical binding]; other site
65393001417	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
65393001418	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
65393001419	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
65393001420	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
65393001421	dimer interface [polypeptide binding]; other site
65393001422	ssDNA binding site [nucleotide binding]; other site
65393001423	tetramer (dimer of dimers) interface [polypeptide binding]; other site
65393001424	Uncharacterized conserved protein [Function unknown]; Region: COG0432
65393001425	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
65393001426	putative active site [active]
65393001427	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
65393001428	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
65393001429	Catalytic site [active]
65393001430	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
65393001431	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
65393001432	homodimer interface [polypeptide binding]; other site
65393001433	metal binding site [ion binding]; metal-binding site
65393001434	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
65393001435	homodimer interface [polypeptide binding]; other site
65393001436	active site
65393001437	putative chemical substrate binding site [chemical binding]; other site
65393001438	metal binding site [ion binding]; metal-binding site
65393001439	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
65393001440	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393001441	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
65393001442	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
65393001443	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65393001444	HSP70 interaction site [polypeptide binding]; other site
65393001445	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393001446	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393001447	Probable transposase; Region: OrfB_IS605; pfam01385
65393001448	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
65393001449	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
65393001450	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65393001451	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393001452	PBP superfamily domain; Region: PBP_like_2; cl17296
65393001453	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65393001454	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
65393001455	Walker A/P-loop; other site
65393001456	ATP binding site [chemical binding]; other site
65393001457	Q-loop/lid; other site
65393001458	ABC transporter signature motif; other site
65393001459	Walker B; other site
65393001460	D-loop; other site
65393001461	H-loop/switch region; other site
65393001462	CpeS-like protein; Region: CpeS; pfam09367
65393001463	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
65393001464	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
65393001465	Patatin-like phospholipase; Region: Patatin; pfam01734
65393001466	active site
65393001467	nucleophile elbow; other site
65393001468	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393001469	Probable transposase; Region: OrfB_IS605; pfam01385
65393001470	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393001471	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
65393001472	pyrroline-5-carboxylate reductase; Region: PLN02688
65393001473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
65393001474	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
65393001475	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
65393001476	catalytic residue [active]
65393001477	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
65393001478	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
65393001479	active site
65393001480	catalytic triad [active]
65393001481	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
65393001482	putative active site [active]
65393001483	putative metal binding residues [ion binding]; other site
65393001484	signature motif; other site
65393001485	putative dimer interface [polypeptide binding]; other site
65393001486	putative phosphate binding site [ion binding]; other site
65393001487	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393001488	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393001489	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393001490	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393001491	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
65393001492	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
65393001493	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
65393001494	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393001495	NurA nuclease; Region: NurA; smart00933
65393001496	GTPase RsgA; Reviewed; Region: PRK12289
65393001497	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
65393001498	RNA binding site [nucleotide binding]; other site
65393001499	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
65393001500	GTPase/Zn-binding domain interface [polypeptide binding]; other site
65393001501	GTP/Mg2+ binding site [chemical binding]; other site
65393001502	G4 box; other site
65393001503	G5 box; other site
65393001504	G1 box; other site
65393001505	Switch I region; other site
65393001506	G2 box; other site
65393001507	G3 box; other site
65393001508	Switch II region; other site
65393001509	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
65393001510	CPxP  motif; other site
65393001511	chaperone protein DnaJ; Provisional; Region: PRK14293
65393001512	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65393001513	HSP70 interaction site [polypeptide binding]; other site
65393001514	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
65393001515	substrate binding site [polypeptide binding]; other site
65393001516	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
65393001517	Zn binding sites [ion binding]; other site
65393001518	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
65393001519	dimer interface [polypeptide binding]; other site
65393001520	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393001521	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393001522	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65393001523	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
65393001524	Peptidase family M23; Region: Peptidase_M23; pfam01551
65393001525	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
65393001526	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
65393001527	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
65393001528	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
65393001529	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
65393001530	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
65393001531	trmE is a tRNA modification GTPase; Region: trmE; cd04164
65393001532	G1 box; other site
65393001533	GTP/Mg2+ binding site [chemical binding]; other site
65393001534	Switch I region; other site
65393001535	G2 box; other site
65393001536	Switch II region; other site
65393001537	G3 box; other site
65393001538	G4 box; other site
65393001539	G5 box; other site
65393001540	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
65393001541	CpeS-like protein; Region: CpeS; pfam09367
65393001542	HEAT repeats; Region: HEAT_2; pfam13646
65393001543	HEAT repeats; Region: HEAT_2; pfam13646
65393001544	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
65393001545	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393001546	putative active site [active]
65393001547	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
65393001548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
65393001549	photosystem II 44 kDa protein; Region: psbC; CHL00035
65393001550	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
65393001551	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
65393001552	D1 interface; other site
65393001553	chlorophyll binding site; other site
65393001554	pheophytin binding site; other site
65393001555	beta carotene binding site; other site
65393001556	cytochrome b559 beta interface; other site
65393001557	quinone binding site; other site
65393001558	cytochrome b559 alpha interface; other site
65393001559	protein J interface; other site
65393001560	protein H interface; other site
65393001561	protein X interface; other site
65393001562	core light harvesting protein interface; other site
65393001563	protein L interface; other site
65393001564	CP43 interface; other site
65393001565	protein T interface; other site
65393001566	Fe binding site [ion binding]; other site
65393001567	protein M interface; other site
65393001568	Mn-stabilizing polypeptide interface; other site
65393001569	bromide binding site; other site
65393001570	cytochrome c-550 interface; other site
65393001571	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
65393001572	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
65393001573	active site
65393001574	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
65393001575	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
65393001576	dimer interface [polypeptide binding]; other site
65393001577	active site
65393001578	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65393001579	HSP70 interaction site [polypeptide binding]; other site
65393001580	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
65393001581	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
65393001582	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
65393001583	tetramer interface [polypeptide binding]; other site
65393001584	TPP-binding site [chemical binding]; other site
65393001585	heterodimer interface [polypeptide binding]; other site
65393001586	phosphorylation loop region [posttranslational modification]
65393001587	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
65393001588	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
65393001589	Inward rectifier potassium channel; Region: IRK; pfam01007
65393001590	Penicillin amidase; Region: Penicil_amidase; pfam01804
65393001591	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
65393001592	active site
65393001593	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
65393001594	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393001595	putative active site [active]
65393001596	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65393001597	active site
65393001598	recombination protein RecR; Reviewed; Region: recR; PRK00076
65393001599	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
65393001600	RecR protein; Region: RecR; pfam02132
65393001601	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
65393001602	putative active site [active]
65393001603	putative metal-binding site [ion binding]; other site
65393001604	tetramer interface [polypeptide binding]; other site
65393001605	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
65393001606	MoaE interaction surface [polypeptide binding]; other site
65393001607	MoeB interaction surface [polypeptide binding]; other site
65393001608	thiocarboxylated glycine; other site
65393001609	threonine synthase; Validated; Region: PRK07591
65393001610	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
65393001611	homodimer interface [polypeptide binding]; other site
65393001612	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393001613	catalytic residue [active]
65393001614	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001615	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393001616	putative active site [active]
65393001617	heme pocket [chemical binding]; other site
65393001618	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393001619	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001620	putative active site [active]
65393001621	heme pocket [chemical binding]; other site
65393001622	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001623	putative active site [active]
65393001624	heme pocket [chemical binding]; other site
65393001625	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001626	PAS fold; Region: PAS_3; pfam08447
65393001627	putative active site [active]
65393001628	heme pocket [chemical binding]; other site
65393001629	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001630	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
65393001631	putative active site [active]
65393001632	heme pocket [chemical binding]; other site
65393001633	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001634	putative active site [active]
65393001635	heme pocket [chemical binding]; other site
65393001636	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001637	putative active site [active]
65393001638	heme pocket [chemical binding]; other site
65393001639	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393001640	metal binding site [ion binding]; metal-binding site
65393001641	active site
65393001642	I-site; other site
65393001643	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393001644	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
65393001645	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
65393001646	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
65393001647	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
65393001648	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
65393001649	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
65393001650	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
65393001651	Walker A motif; other site
65393001652	ATP binding site [chemical binding]; other site
65393001653	Walker B motif; other site
65393001654	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
65393001655	ATP binding site [chemical binding]; other site
65393001656	Walker B motif; other site
65393001657	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
65393001658	tetramer interface [polypeptide binding]; other site
65393001659	dimer interface [polypeptide binding]; other site
65393001660	KaiA domain; Region: KaiA; pfam07688
65393001661	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
65393001662	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393001663	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393001664	dimer interface [polypeptide binding]; other site
65393001665	phosphorylation site [posttranslational modification]
65393001666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393001667	ATP binding site [chemical binding]; other site
65393001668	Mg2+ binding site [ion binding]; other site
65393001669	G-X-G motif; other site
65393001670	Response regulator receiver domain; Region: Response_reg; pfam00072
65393001671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393001672	active site
65393001673	phosphorylation site [posttranslational modification]
65393001674	intermolecular recognition site; other site
65393001675	dimerization interface [polypeptide binding]; other site
65393001676	RDD family; Region: RDD; pfam06271
65393001677	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
65393001678	C-terminal peptidase (prc); Region: prc; TIGR00225
65393001679	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
65393001680	protein binding site [polypeptide binding]; other site
65393001681	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
65393001682	Catalytic dyad [active]
65393001683	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
65393001684	nudix motif; other site
65393001685	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
65393001686	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
65393001687	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
65393001688	homodimer interface [polypeptide binding]; other site
65393001689	NADP binding site [chemical binding]; other site
65393001690	substrate binding site [chemical binding]; other site
65393001691	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
65393001692	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
65393001693	substrate binding pocket [chemical binding]; other site
65393001694	chain length determination region; other site
65393001695	substrate-Mg2+ binding site; other site
65393001696	catalytic residues [active]
65393001697	aspartate-rich region 1; other site
65393001698	active site lid residues [active]
65393001699	aspartate-rich region 2; other site
65393001700	Divergent PAP2 family; Region: DUF212; pfam02681
65393001701	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65393001702	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
65393001703	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
65393001704	cyanophycin synthetase; Provisional; Region: PRK14016
65393001705	ATP-grasp domain; Region: ATP-grasp_4; cl17255
65393001706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393001707	Walker B; other site
65393001708	H-loop/switch region; other site
65393001709	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
65393001710	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
65393001711	CAAX protease self-immunity; Region: Abi; pfam02517
65393001712	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
65393001713	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393001714	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
65393001715	protein binding site [polypeptide binding]; other site
65393001716	Uncharacterized conserved protein [Function unknown]; Region: COG0398
65393001717	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
65393001718	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
65393001719	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
65393001720	NTPase; Region: NTPase_1; cl17478
65393001721	HEAT repeats; Region: HEAT_2; pfam13646
65393001722	HEAT repeats; Region: HEAT_2; pfam13646
65393001723	Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957
65393001724	active site
65393001725	Protein phosphatase 2C; Region: PP2C; pfam00481
65393001726	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
65393001727	active site
65393001728	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
65393001729	ABC1 family; Region: ABC1; cl17513
65393001730	Frequency clock protein; Region: FRQ; pfam09421
65393001731	Double zinc ribbon; Region: DZR; pfam12773
65393001732	uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792
65393001733	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
65393001734	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65393001735	HSP70 interaction site [polypeptide binding]; other site
65393001736	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393001737	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393001738	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393001739	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393001740	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
65393001741	Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729
65393001742	putative active site [active]
65393001743	redox center [active]
65393001744	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
65393001745	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
65393001746	metal binding site [ion binding]; metal-binding site
65393001747	dimer interface [polypeptide binding]; other site
65393001748	BON domain; Region: BON; pfam04972
65393001749	na(+)/h(+) antiporter; Region: c_cpa1; TIGR00844
65393001750	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
65393001751	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393001752	dimer interface [polypeptide binding]; other site
65393001753	conserved gate region; other site
65393001754	putative PBP binding loops; other site
65393001755	ABC-ATPase subunit interface; other site
65393001756	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
65393001757	NMT1-like family; Region: NMT1_2; pfam13379
65393001758	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
65393001759	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
65393001760	Walker A/P-loop; other site
65393001761	ATP binding site [chemical binding]; other site
65393001762	Q-loop/lid; other site
65393001763	ABC transporter signature motif; other site
65393001764	Walker B; other site
65393001765	D-loop; other site
65393001766	H-loop/switch region; other site
65393001767	methionine aminopeptidase; Provisional; Region: PRK08671
65393001768	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
65393001769	active site
65393001770	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
65393001771	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393001772	Coenzyme A binding pocket [chemical binding]; other site
65393001773	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
65393001774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393001775	Walker A motif; other site
65393001776	ATP binding site [chemical binding]; other site
65393001777	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
65393001778	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
65393001779	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
65393001780	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
65393001781	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393001782	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
65393001783	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
65393001784	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
65393001785	putative dimer interface [polypeptide binding]; other site
65393001786	N-terminal domain interface [polypeptide binding]; other site
65393001787	putative substrate binding pocket (H-site) [chemical binding]; other site
65393001788	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
65393001789	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
65393001790	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
65393001791	PUCC protein; Region: PUCC; pfam03209
65393001792	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
65393001793	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
65393001794	active site
65393001795	metal binding site [ion binding]; metal-binding site
65393001796	DNA binding site [nucleotide binding]
65393001797	HEAT repeats; Region: HEAT_2; pfam13646
65393001798	HEAT repeats; Region: HEAT_2; pfam13646
65393001799	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65393001800	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393001801	Transcriptional regulator [Transcription]; Region: LysR; COG0583
65393001802	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
65393001803	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
65393001804	dimerization interface [polypeptide binding]; other site
65393001805	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
65393001806	Transmembrane proteins 14C; Region: Tmemb_14; cl02346
65393001807	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
65393001808	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
65393001809	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
65393001810	C-terminal domain interface [polypeptide binding]; other site
65393001811	active site
65393001812	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
65393001813	active site
65393001814	Caspase domain; Region: Peptidase_C14; pfam00656
65393001815	Uncharacterized conserved protein [Function unknown]; Region: COG1262
65393001816	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
65393001817	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
65393001818	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
65393001819	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393001820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393001821	active site
65393001822	phosphorylation site [posttranslational modification]
65393001823	intermolecular recognition site; other site
65393001824	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393001825	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393001826	PAS fold; Region: PAS; pfam00989
65393001827	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001828	putative active site [active]
65393001829	heme pocket [chemical binding]; other site
65393001830	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393001831	putative active site [active]
65393001832	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
65393001833	heme pocket [chemical binding]; other site
65393001834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393001835	dimer interface [polypeptide binding]; other site
65393001836	phosphorylation site [posttranslational modification]
65393001837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393001838	ATP binding site [chemical binding]; other site
65393001839	Mg2+ binding site [ion binding]; other site
65393001840	G-X-G motif; other site
65393001841	Response regulator receiver domain; Region: Response_reg; pfam00072
65393001842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393001843	active site
65393001844	phosphorylation site [posttranslational modification]
65393001845	intermolecular recognition site; other site
65393001846	dimerization interface [polypeptide binding]; other site
65393001847	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393001848	Coenzyme A binding pocket [chemical binding]; other site
65393001849	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
65393001850	putative hydrophobic ligand binding site [chemical binding]; other site
65393001851	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
65393001852	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393001853	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
65393001854	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393001855	S-adenosylmethionine binding site [chemical binding]; other site
65393001856	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
65393001857	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
65393001858	active site residue [active]
65393001859	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
65393001860	S-layer homology domain; Region: SLH; pfam00395
65393001861	S-layer homology domain; Region: SLH; pfam00395
65393001862	Yqey-like protein; Region: YqeY; pfam09424
65393001863	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
65393001864	acetolactate synthase; Reviewed; Region: PRK08322
65393001865	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
65393001866	PYR/PP interface [polypeptide binding]; other site
65393001867	dimer interface [polypeptide binding]; other site
65393001868	TPP binding site [chemical binding]; other site
65393001869	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
65393001870	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
65393001871	TPP-binding site [chemical binding]; other site
65393001872	dimer interface [polypeptide binding]; other site
65393001873	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393001874	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393001875	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393001876	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393001877	metal binding site [ion binding]; metal-binding site
65393001878	active site
65393001879	I-site; other site
65393001880	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
65393001881	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
65393001882	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
65393001883	shikimate binding site; other site
65393001884	NAD(P) binding site [chemical binding]; other site
65393001885	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393001886	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393001887	active site
65393001888	phosphorylation site [posttranslational modification]
65393001889	intermolecular recognition site; other site
65393001890	dimerization interface [polypeptide binding]; other site
65393001891	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393001892	DNA binding site [nucleotide binding]
65393001893	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393001894	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393001895	dimer interface [polypeptide binding]; other site
65393001896	phosphorylation site [posttranslational modification]
65393001897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393001898	ATP binding site [chemical binding]; other site
65393001899	Mg2+ binding site [ion binding]; other site
65393001900	G-X-G motif; other site
65393001901	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
65393001902	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
65393001903	putative active site [active]
65393001904	catalytic site [active]
65393001905	putative metal binding site [ion binding]; other site
65393001906	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
65393001907	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
65393001908	active site
65393001909	catalytic site [active]
65393001910	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
65393001911	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
65393001912	oligomeric interface; other site
65393001913	putative active site [active]
65393001914	homodimer interface [polypeptide binding]; other site
65393001915	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
65393001916	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
65393001917	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
65393001918	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
65393001919	Domain of unknown function DUF21; Region: DUF21; pfam01595
65393001920	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
65393001921	Transporter associated domain; Region: CorC_HlyC; smart01091
65393001922	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
65393001923	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
65393001924	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
65393001925	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393001926	TPR motif; other site
65393001927	TPR repeat; Region: TPR_11; pfam13414
65393001928	binding surface
65393001929	TPR repeat; Region: TPR_11; pfam13414
65393001930	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
65393001931	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
65393001932	Domain of unknown function (DUF814); Region: DUF814; pfam05670
65393001933	Rhomboid family; Region: Rhomboid; pfam01694
65393001934	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
65393001935	catalytic motif [active]
65393001936	Zn binding site [ion binding]; other site
65393001937	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393001938	putative active site [active]
65393001939	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
65393001940	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
65393001941	substrate binding pocket [chemical binding]; other site
65393001942	membrane-bound complex binding site; other site
65393001943	hinge residues; other site
65393001944	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
65393001945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
65393001946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393001947	putative PBP binding loops; other site
65393001948	dimer interface [polypeptide binding]; other site
65393001949	ABC-ATPase subunit interface; other site
65393001950	TIR domain; Region: TIR_2; pfam13676
65393001951	TIR domain; Region: TIR_2; pfam13676
65393001952	TIR domain; Region: TIR_2; pfam13676
65393001953	WD domain, G-beta repeat; Region: WD40; pfam00400
65393001954	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393001955	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393001956	structural tetrad; other site
65393001957	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393001958	structural tetrad; other site
65393001959	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
65393001960	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393001961	dimer interface [polypeptide binding]; other site
65393001962	conserved gate region; other site
65393001963	putative PBP binding loops; other site
65393001964	ABC-ATPase subunit interface; other site
65393001965	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
65393001966	IHF dimer interface [polypeptide binding]; other site
65393001967	IHF - DNA interface [nucleotide binding]; other site
65393001968	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
65393001969	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65393001970	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393001971	homodimer interface [polypeptide binding]; other site
65393001972	catalytic residue [active]
65393001973	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
65393001974	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65393001975	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
65393001976	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393001977	putative active site [active]
65393001978	thymidylate kinase; Region: DTMP_kinase; TIGR00041
65393001979	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
65393001980	TMP-binding site; other site
65393001981	ATP-binding site [chemical binding]; other site
65393001982	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
65393001983	dimerization interface [polypeptide binding]; other site
65393001984	active site
65393001985	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
65393001986	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
65393001987	trimer interface [polypeptide binding]; other site
65393001988	active site
65393001989	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
65393001990	trimer interface [polypeptide binding]; other site
65393001991	active site
65393001992	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65393001993	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393001994	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393001995	Walker A/P-loop; other site
65393001996	ATP binding site [chemical binding]; other site
65393001997	Q-loop/lid; other site
65393001998	ABC transporter signature motif; other site
65393001999	Walker B; other site
65393002000	D-loop; other site
65393002001	H-loop/switch region; other site
65393002002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393002003	putative substrate translocation pore; other site
65393002004	Major Facilitator Superfamily; Region: MFS_1; pfam07690
65393002005	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
65393002006	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
65393002007	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393002008	Calx-beta domain; Region: Calx-beta; cl02522
65393002009	Calx-beta domain; Region: Calx-beta; cl02522
65393002010	Calx-beta domain; Region: Calx-beta; cl02522
65393002011	Calx-beta domain; Region: Calx-beta; cl02522
65393002012	Calx-beta domain; Region: Calx-beta; cl02522
65393002013	Calx-beta domain; Region: Calx-beta; cl02522
65393002014	Calx-beta domain; Region: Calx-beta; cl02522
65393002015	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
65393002016	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
65393002017	NAD binding site [chemical binding]; other site
65393002018	dimerization interface [polypeptide binding]; other site
65393002019	product binding site; other site
65393002020	substrate binding site [chemical binding]; other site
65393002021	zinc binding site [ion binding]; other site
65393002022	catalytic residues [active]
65393002023	ribosomal protein S20; Region: rps20; CHL00102
65393002024	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
65393002025	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
65393002026	active site
65393002027	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
65393002028	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
65393002029	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
65393002030	RPB1 interaction site [polypeptide binding]; other site
65393002031	RPB10 interaction site [polypeptide binding]; other site
65393002032	RPB11 interaction site [polypeptide binding]; other site
65393002033	RPB3 interaction site [polypeptide binding]; other site
65393002034	RPB12 interaction site [polypeptide binding]; other site
65393002035	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
65393002036	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
65393002037	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
65393002038	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
65393002039	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
65393002040	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
65393002041	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
65393002042	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
65393002043	DNA binding site [nucleotide binding]
65393002044	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
65393002045	envelope glycoprotein E; Provisional; Region: PHA03283
65393002046	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
65393002047	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
65393002048	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
65393002049	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65393002050	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
65393002051	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393002052	S-adenosylmethionine binding site [chemical binding]; other site
65393002053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
65393002054	Lysozyme family protein [General function prediction only]; Region: COG5526
65393002055	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
65393002056	CHAP domain; Region: CHAP; cl17642
65393002057	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393002058	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393002059	Probable transposase; Region: OrfB_IS605; pfam01385
65393002060	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393002061	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
65393002062	active site flap/lid [active]
65393002063	nucleophilic elbow; other site
65393002064	catalytic triad [active]
65393002065	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
65393002066	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
65393002067	DNA binding residues [nucleotide binding]
65393002068	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
65393002069	catalytic residues [active]
65393002070	catalytic nucleophile [active]
65393002071	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
65393002072	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
65393002073	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
65393002074	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
65393002075	dihydrodipicolinate synthase; Region: dapA; TIGR00674
65393002076	dimer interface [polypeptide binding]; other site
65393002077	active site
65393002078	catalytic residue [active]
65393002079	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
65393002080	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
65393002081	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
65393002082	ATP-sulfurylase; Region: ATPS; cd00517
65393002083	active site
65393002084	HXXH motif; other site
65393002085	flexible loop; other site
65393002086	Caspase domain; Region: Peptidase_C14; pfam00656
65393002087	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
65393002088	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
65393002089	hydrophobic ligand binding site; other site
65393002090	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
65393002091	active site
65393002092	catalytic triad [active]
65393002093	oxyanion hole [active]
65393002094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
65393002095	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
65393002096	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
65393002097	O-Antigen ligase; Region: Wzy_C; pfam04932
65393002098	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
65393002099	nitrilase; Region: PLN02798
65393002100	putative active site [active]
65393002101	catalytic triad [active]
65393002102	dimer interface [polypeptide binding]; other site
65393002103	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
65393002104	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
65393002105	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65393002106	catalytic residue [active]
65393002107	Flagellin N-methylase; Region: FliB; pfam03692
65393002108	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
65393002109	substrate binding pocket [chemical binding]; other site
65393002110	substrate-Mg2+ binding site; other site
65393002111	aspartate-rich region 1; other site
65393002112	aspartate-rich region 2; other site
65393002113	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002114	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002115	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
65393002116	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
65393002117	active site
65393002118	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65393002119	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
65393002120	HlyD family secretion protein; Region: HlyD_3; pfam13437
65393002121	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
65393002122	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393002123	Coenzyme A binding pocket [chemical binding]; other site
65393002124	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393002125	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393002126	Probable transposase; Region: OrfB_IS605; pfam01385
65393002127	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393002128	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65393002129	CRISPR-associated protein; Region: DUF3692; pfam12469
65393002130	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
65393002131	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
65393002132	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
65393002133	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
65393002134	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
65393002135	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
65393002136	putative active site [active]
65393002137	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
65393002138	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
65393002139	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
65393002140	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
65393002141	S-layer homology domain; Region: SLH; pfam00395
65393002142	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
65393002143	FeoA domain; Region: FeoA; pfam04023
65393002144	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
65393002145	PAAR motif; Region: PAAR_motif; pfam05488
65393002146	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
65393002147	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
65393002148	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
65393002149	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
65393002150	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
65393002151	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393002152	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393002153	dimer interface [polypeptide binding]; other site
65393002154	phosphorylation site [posttranslational modification]
65393002155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393002156	ATP binding site [chemical binding]; other site
65393002157	Mg2+ binding site [ion binding]; other site
65393002158	G-X-G motif; other site
65393002159	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393002160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393002161	active site
65393002162	phosphorylation site [posttranslational modification]
65393002163	intermolecular recognition site; other site
65393002164	dimerization interface [polypeptide binding]; other site
65393002165	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393002166	DNA binding residues [nucleotide binding]
65393002167	dimerization interface [polypeptide binding]; other site
65393002168	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393002169	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393002170	active site
65393002171	ATP binding site [chemical binding]; other site
65393002172	substrate binding site [chemical binding]; other site
65393002173	activation loop (A-loop); other site
65393002174	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393002175	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393002176	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393002177	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
65393002178	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65393002179	catalytic residues [active]
65393002180	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
65393002181	photosystem II reaction center protein J; Provisional; Region: PRK02565
65393002182	photosystem II reaction center L; Provisional; Region: psbL; PRK00753
65393002183	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
65393002184	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
65393002185	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
65393002186	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
65393002187	Ycf48-like protein; Provisional; Region: PRK13684
65393002188	Rubredoxin [Energy production and conversion]; Region: COG1773
65393002189	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
65393002190	iron binding site [ion binding]; other site
65393002191	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
65393002192	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
65393002193	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393002194	putative active site [active]
65393002195	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393002196	putative active site [active]
65393002197	ParA-like protein; Provisional; Region: PHA02518
65393002198	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65393002199	P-loop; other site
65393002200	Magnesium ion binding site [ion binding]; other site
65393002201	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393002202	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393002203	Probable transposase; Region: OrfB_IS605; pfam01385
65393002204	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002205	TPR repeat; Region: TPR_11; pfam13414
65393002206	binding surface
65393002207	TPR motif; other site
65393002208	TPR repeat; Region: TPR_11; pfam13414
65393002209	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002210	binding surface
65393002211	TPR repeat; Region: TPR_11; pfam13414
65393002212	TPR motif; other site
65393002213	TPR repeat; Region: TPR_11; pfam13414
65393002214	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002215	binding surface
65393002216	TPR motif; other site
65393002217	Tetratricopeptide repeat; Region: TPR_9; pfam13371
65393002218	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
65393002219	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
65393002220	acyl-activating enzyme (AAE) consensus motif; other site
65393002221	AMP binding site [chemical binding]; other site
65393002222	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393002223	Condensation domain; Region: Condensation; pfam00668
65393002224	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393002225	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
65393002226	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393002227	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
65393002228	Cna protein B-type domain; Region: Cna_B; pfam05738
65393002229	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
65393002230	Protein of unknown function (DUF790); Region: DUF790; pfam05626
65393002231	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
65393002232	Cytochrome P450; Region: p450; cl12078
65393002233	C factor cell-cell signaling protein; Provisional; Region: PRK09009
65393002234	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
65393002235	NADP binding site [chemical binding]; other site
65393002236	homodimer interface [polypeptide binding]; other site
65393002237	active site
65393002238	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
65393002239	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393002240	phosphopeptide binding site; other site
65393002241	Protease prsW family; Region: PrsW-protease; pfam13367
65393002242	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
65393002243	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
65393002244	C-terminal domain interface [polypeptide binding]; other site
65393002245	GSH binding site (G-site) [chemical binding]; other site
65393002246	dimer interface [polypeptide binding]; other site
65393002247	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
65393002248	N-terminal domain interface [polypeptide binding]; other site
65393002249	dimer interface [polypeptide binding]; other site
65393002250	substrate binding pocket (H-site) [chemical binding]; other site
65393002251	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
65393002252	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
65393002253	haemagglutination activity domain; Region: Haemagg_act; pfam05860
65393002254	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
65393002255	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
65393002256	NAD(P) binding pocket [chemical binding]; other site
65393002257	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
65393002258	Ycf35; Provisional; Region: ycf35; CHL00193
65393002259	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
65393002260	yiaA/B two helix domain; Region: YiaAB; cl01759
65393002261	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
65393002262	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
65393002263	acyl-activating enzyme (AAE) consensus motif; other site
65393002264	diaminopimelate decarboxylase; Region: lysA; TIGR01048
65393002265	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
65393002266	active site
65393002267	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
65393002268	substrate binding site [chemical binding]; other site
65393002269	catalytic residues [active]
65393002270	dimer interface [polypeptide binding]; other site
65393002271	TIGR00159 family protein; Region: TIGR00159
65393002272	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
65393002273	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
65393002274	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
65393002275	catalytic residue [active]
65393002276	putative FPP diphosphate  binding site; other site
65393002277	putative FPP binding hydrophobic cleft; other site
65393002278	dimer interface [polypeptide binding]; other site
65393002279	putative IPP diphosphate binding site; other site
65393002280	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393002281	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65393002282	YcfA-like protein; Region: YcfA; pfam07927
65393002283	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
65393002284	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
65393002285	substrate binding site [chemical binding]; other site
65393002286	ligand binding site [chemical binding]; other site
65393002287	EcsC protein family; Region: EcsC; pfam12787
65393002288	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
65393002289	active site
65393002290	catalytic triad [active]
65393002291	oxyanion hole [active]
65393002292	Amino acid permease; Region: AA_permease; pfam00324
65393002293	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
65393002294	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393002295	Q-loop/lid; other site
65393002296	ABC transporter signature motif; other site
65393002297	Walker B; other site
65393002298	D-loop; other site
65393002299	H-loop/switch region; other site
65393002300	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65393002301	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65393002302	active site
65393002303	Probable transposase; Region: OrfB_IS605; pfam01385
65393002304	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393002305	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
65393002306	alanine racemase; Reviewed; Region: alr; PRK00053
65393002307	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
65393002308	active site
65393002309	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
65393002310	dimer interface [polypeptide binding]; other site
65393002311	substrate binding site [chemical binding]; other site
65393002312	catalytic residues [active]
65393002313	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002314	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002315	TPR motif; other site
65393002316	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002317	binding surface
65393002318	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002319	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002320	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002321	binding surface
65393002322	TPR motif; other site
65393002323	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002324	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002325	binding surface
65393002326	TPR motif; other site
65393002327	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002328	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002329	binding surface
65393002330	TPR motif; other site
65393002331	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002332	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002333	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002334	binding surface
65393002335	TPR motif; other site
65393002336	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002337	CHAT domain; Region: CHAT; pfam12770
65393002338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002339	TPR motif; other site
65393002340	binding surface
65393002341	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002342	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002343	binding surface
65393002344	TPR motif; other site
65393002345	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002346	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002347	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002349	binding surface
65393002350	TPR motif; other site
65393002351	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002352	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002353	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002354	binding surface
65393002355	TPR motif; other site
65393002356	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002357	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002358	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002359	binding surface
65393002360	TPR motif; other site
65393002361	TPR repeat; Region: TPR_11; pfam13414
65393002362	CHAT domain; Region: CHAT; pfam12770
65393002363	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
65393002364	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
65393002365	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
65393002366	putative ligand binding site [chemical binding]; other site
65393002367	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
65393002368	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
65393002369	NlpC/P60 family; Region: NLPC_P60; pfam00877
65393002370	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
65393002371	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
65393002372	Walker A/P-loop; other site
65393002373	ATP binding site [chemical binding]; other site
65393002374	Q-loop/lid; other site
65393002375	ABC transporter signature motif; other site
65393002376	Walker B; other site
65393002377	D-loop; other site
65393002378	H-loop/switch region; other site
65393002379	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
65393002380	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
65393002381	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
65393002382	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
65393002383	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
65393002384	proposed catalytic triad [active]
65393002385	active site nucleophile [active]
65393002386	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
65393002387	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002388	TPR motif; other site
65393002389	binding surface
65393002390	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393002391	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65393002392	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
65393002393	Walker A/P-loop; other site
65393002394	ATP binding site [chemical binding]; other site
65393002395	Q-loop/lid; other site
65393002396	ABC transporter signature motif; other site
65393002397	Walker B; other site
65393002398	D-loop; other site
65393002399	H-loop/switch region; other site
65393002400	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
65393002401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393002402	S-adenosylmethionine binding site [chemical binding]; other site
65393002403	Cytochrome c; Region: Cytochrom_C; cl11414
65393002404	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
65393002405	MAPEG family; Region: MAPEG; pfam01124
65393002406	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
65393002407	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
65393002408	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
65393002409	putative active site [active]
65393002410	substrate binding site [chemical binding]; other site
65393002411	putative cosubstrate binding site; other site
65393002412	catalytic site [active]
65393002413	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
65393002414	substrate binding site [chemical binding]; other site
65393002415	Cobalt transport protein; Region: CbiQ; pfam02361
65393002416	GTP-binding protein Der; Reviewed; Region: PRK00093
65393002417	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
65393002418	G1 box; other site
65393002419	GTP/Mg2+ binding site [chemical binding]; other site
65393002420	Switch I region; other site
65393002421	G2 box; other site
65393002422	Switch II region; other site
65393002423	G3 box; other site
65393002424	G4 box; other site
65393002425	G5 box; other site
65393002426	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
65393002427	G1 box; other site
65393002428	GTP/Mg2+ binding site [chemical binding]; other site
65393002429	Switch I region; other site
65393002430	G2 box; other site
65393002431	G3 box; other site
65393002432	Switch II region; other site
65393002433	G4 box; other site
65393002434	G5 box; other site
65393002435	YCII-related domain; Region: YCII; cl00999
65393002436	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
65393002437	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
65393002438	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
65393002439	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
65393002440	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
65393002441	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393002442	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393002443	putative active site [active]
65393002444	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
65393002445	active site residue [active]
65393002446	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
65393002447	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
65393002448	G-X-X-G motif; other site
65393002449	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
65393002450	RxxxH motif; other site
65393002451	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
65393002452	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
65393002453	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
65393002454	Bacterial PH domain; Region: DUF304; pfam03703
65393002455	ribonuclease P; Reviewed; Region: rnpA; PRK03031
65393002456	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
65393002457	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
65393002458	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
65393002459	motif 1; other site
65393002460	active site
65393002461	motif 2; other site
65393002462	motif 3; other site
65393002463	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
65393002464	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
65393002465	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
65393002466	RloB-like protein; Region: RloB; pfam13707
65393002467	AAA domain; Region: AAA_21; pfam13304
65393002468	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
65393002469	TrkA-N domain; Region: TrkA_N; pfam02254
65393002470	TrkA-C domain; Region: TrkA_C; pfam02080
65393002471	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
65393002472	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
65393002473	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
65393002474	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
65393002475	RNA binding surface [nucleotide binding]; other site
65393002476	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
65393002477	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
65393002478	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
65393002479	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65393002480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393002481	S-adenosylmethionine binding site [chemical binding]; other site
65393002482	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
65393002483	hypothetical protein; Provisional; Region: PRK07338
65393002484	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
65393002485	metal binding site [ion binding]; metal-binding site
65393002486	dimer interface [polypeptide binding]; other site
65393002487	Flavin Reductases; Region: FlaRed; cl00801
65393002488	O-succinylbenzoate synthase; Provisional; Region: PRK02714
65393002489	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
65393002490	active site
65393002491	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
65393002492	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
65393002493	acyl-activating enzyme (AAE) consensus motif; other site
65393002494	putative AMP binding site [chemical binding]; other site
65393002495	putative active site [active]
65393002496	putative CoA binding site [chemical binding]; other site
65393002497	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393002498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393002499	active site
65393002500	phosphorylation site [posttranslational modification]
65393002501	intermolecular recognition site; other site
65393002502	dimerization interface [polypeptide binding]; other site
65393002503	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393002504	DNA binding site [nucleotide binding]
65393002505	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
65393002506	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
65393002507	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
65393002508	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
65393002509	FtsX-like permease family; Region: FtsX; pfam02687
65393002510	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
65393002511	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65393002512	HlyD family secretion protein; Region: HlyD_3; pfam13437
65393002513	TPR repeat; Region: TPR_11; pfam13414
65393002514	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002515	binding surface
65393002516	TPR motif; other site
65393002517	TPR repeat; Region: TPR_11; pfam13414
65393002518	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002519	binding surface
65393002520	TPR repeat; Region: TPR_11; pfam13414
65393002521	TPR motif; other site
65393002522	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002523	TPR repeat; Region: TPR_11; pfam13414
65393002524	binding surface
65393002525	TPR motif; other site
65393002526	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393002527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393002528	active site
65393002529	phosphorylation site [posttranslational modification]
65393002530	intermolecular recognition site; other site
65393002531	dimerization interface [polypeptide binding]; other site
65393002532	DNA gyrase subunit A; Validated; Region: PRK05560
65393002533	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
65393002534	CAP-like domain; other site
65393002535	active site
65393002536	primary dimer interface [polypeptide binding]; other site
65393002537	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65393002538	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65393002539	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65393002540	Uncharacterized conserved protein [Function unknown]; Region: COG1434
65393002541	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
65393002542	putative active site [active]
65393002543	Pirin-related protein [General function prediction only]; Region: COG1741
65393002544	Pirin; Region: Pirin; pfam02678
65393002545	Predicted transcriptional regulators [Transcription]; Region: COG1733
65393002546	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
65393002547	dimerization interface [polypeptide binding]; other site
65393002548	putative DNA binding site [nucleotide binding]; other site
65393002549	putative Zn2+ binding site [ion binding]; other site
65393002550	TPR repeat; Region: TPR_11; pfam13414
65393002551	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002552	binding surface
65393002553	TPR motif; other site
65393002554	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393002555	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
65393002556	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
65393002557	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65393002558	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65393002559	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65393002560	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
65393002561	catalytic site [active]
65393002562	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
65393002563	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
65393002564	catalytic residues [active]
65393002565	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
65393002566	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393002567	Protein kinase domain; Region: Pkinase; pfam00069
65393002568	active site
65393002569	ATP binding site [chemical binding]; other site
65393002570	substrate binding site [chemical binding]; other site
65393002571	activation loop (A-loop); other site
65393002572	TPR repeat; Region: TPR_11; pfam13414
65393002573	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
65393002574	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
65393002575	putative ligand binding site [chemical binding]; other site
65393002576	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393002577	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393002578	active site
65393002579	ATP binding site [chemical binding]; other site
65393002580	substrate binding site [chemical binding]; other site
65393002581	activation loop (A-loop); other site
65393002582	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
65393002583	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
65393002584	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
65393002585	Protein kinase domain; Region: Pkinase; pfam00069
65393002586	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393002587	active site
65393002588	ATP binding site [chemical binding]; other site
65393002589	substrate binding site [chemical binding]; other site
65393002590	activation loop (A-loop); other site
65393002591	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
65393002592	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
65393002593	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
65393002594	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
65393002595	Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948
65393002596	homocitrate synthase; Region: LysS_fung_arch; TIGR02146
65393002597	active site
65393002598	catalytic residues [active]
65393002599	metal binding site [ion binding]; metal-binding site
65393002600	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
65393002601	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
65393002602	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393002603	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393002604	active site
65393002605	phosphorylation site [posttranslational modification]
65393002606	intermolecular recognition site; other site
65393002607	dimerization interface [polypeptide binding]; other site
65393002608	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393002609	DNA binding site [nucleotide binding]
65393002610	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393002611	dimer interface [polypeptide binding]; other site
65393002612	phosphorylation site [posttranslational modification]
65393002613	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393002614	ATP binding site [chemical binding]; other site
65393002615	Mg2+ binding site [ion binding]; other site
65393002616	G-X-G motif; other site
65393002617	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
65393002618	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
65393002619	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
65393002620	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
65393002621	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
65393002622	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
65393002623	putative dimer interface [polypeptide binding]; other site
65393002624	N-terminal domain interface [polypeptide binding]; other site
65393002625	putative substrate binding pocket (H-site) [chemical binding]; other site
65393002626	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393002627	putative active site [active]
65393002628	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
65393002629	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
65393002630	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
65393002631	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
65393002632	dimer interface [polypeptide binding]; other site
65393002633	active site
65393002634	catalytic residue [active]
65393002635	metal binding site [ion binding]; metal-binding site
65393002636	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
65393002637	metal binding site [ion binding]; metal-binding site
65393002638	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
65393002639	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
65393002640	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393002641	putative active site [active]
65393002642	Src Homology 3 domain superfamily; Region: SH3; cl17036
65393002643	peptide ligand binding site [polypeptide binding]; other site
65393002644	Ycf46; Provisional; Region: ycf46; CHL00195
65393002645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393002646	Walker A motif; other site
65393002647	ATP binding site [chemical binding]; other site
65393002648	Walker B motif; other site
65393002649	arginine finger; other site
65393002650	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
65393002651	pheophorbide a oxygenase; Region: PLN02518
65393002652	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
65393002653	iron-sulfur cluster [ion binding]; other site
65393002654	[2Fe-2S] cluster binding site [ion binding]; other site
65393002655	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
65393002656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393002657	S-adenosylmethionine binding site [chemical binding]; other site
65393002658	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
65393002659	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
65393002660	oligomerization interface [polypeptide binding]; other site
65393002661	active site
65393002662	metal binding site [ion binding]; metal-binding site
65393002663	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
65393002664	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
65393002665	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
65393002666	putative active site [active]
65393002667	putative NTP binding site [chemical binding]; other site
65393002668	putative nucleic acid binding site [nucleotide binding]; other site
65393002669	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
65393002670	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65393002671	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65393002672	active site
65393002673	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
65393002674	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
65393002675	putative active site [active]
65393002676	putative NTP binding site [chemical binding]; other site
65393002677	putative nucleic acid binding site [nucleotide binding]; other site
65393002678	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
65393002679	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
65393002680	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
65393002681	DNA binding residues [nucleotide binding]
65393002682	putative dimer interface [polypeptide binding]; other site
65393002683	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
65393002684	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
65393002685	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393002686	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
65393002687	TniQ; Region: TniQ; pfam06527
65393002688	Bacterial TniB protein; Region: TniB; pfam05621
65393002689	AAA domain; Region: AAA_22; pfam13401
65393002690	Helix-turn-helix domain; Region: HTH_28; pfam13518
65393002691	Winged helix-turn helix; Region: HTH_29; pfam13551
65393002692	Integrase core domain; Region: rve; pfam00665
65393002693	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
65393002694	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
65393002695	trimer interface [polypeptide binding]; other site
65393002696	dimer interface [polypeptide binding]; other site
65393002697	putative active site [active]
65393002698	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
65393002699	2TM domain; Region: 2TM; pfam13239
65393002700	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
65393002701	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
65393002702	nudix motif; other site
65393002703	Response regulator receiver domain; Region: Response_reg; pfam00072
65393002704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393002705	active site
65393002706	phosphorylation site [posttranslational modification]
65393002707	intermolecular recognition site; other site
65393002708	dimerization interface [polypeptide binding]; other site
65393002709	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393002710	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393002711	metal binding site [ion binding]; metal-binding site
65393002712	active site
65393002713	I-site; other site
65393002714	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
65393002715	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
65393002716	Walker A/P-loop; other site
65393002717	ATP binding site [chemical binding]; other site
65393002718	Q-loop/lid; other site
65393002719	ABC transporter signature motif; other site
65393002720	Walker B; other site
65393002721	D-loop; other site
65393002722	H-loop/switch region; other site
65393002723	Response regulator receiver domain; Region: Response_reg; pfam00072
65393002724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393002725	active site
65393002726	phosphorylation site [posttranslational modification]
65393002727	intermolecular recognition site; other site
65393002728	dimerization interface [polypeptide binding]; other site
65393002729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393002730	active site
65393002731	phosphorylation site [posttranslational modification]
65393002732	intermolecular recognition site; other site
65393002733	ParB-like nuclease domain; Region: ParBc; cl02129
65393002734	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65393002735	non-specific DNA binding site [nucleotide binding]; other site
65393002736	salt bridge; other site
65393002737	sequence-specific DNA binding site [nucleotide binding]; other site
65393002738	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
65393002739	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
65393002740	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
65393002741	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
65393002742	active site
65393002743	ATP binding site [chemical binding]; other site
65393002744	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393002745	Coenzyme A binding pocket [chemical binding]; other site
65393002746	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393002747	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393002748	dimer interface [polypeptide binding]; other site
65393002749	phosphorylation site [posttranslational modification]
65393002750	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
65393002751	TPR repeat; Region: TPR_11; pfam13414
65393002752	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393002753	binding surface
65393002754	TPR repeat; Region: TPR_11; pfam13414
65393002755	TPR motif; other site
65393002756	TPR repeat; Region: TPR_11; pfam13414
65393002757	Protein of unknown function DUF86; Region: DUF86; cl01031
65393002758	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65393002759	active site
65393002760	NTP binding site [chemical binding]; other site
65393002761	metal binding triad [ion binding]; metal-binding site
65393002762	antibiotic binding site [chemical binding]; other site
65393002763	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
65393002764	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
65393002765	DNA binding residues [nucleotide binding]
65393002766	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
65393002767	catalytic residues [active]
65393002768	catalytic nucleophile [active]
65393002769	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393002770	Probable transposase; Region: OrfB_IS605; pfam01385
65393002771	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393002772	Proline dehydrogenase; Region: Pro_dh; pfam01619
65393002773	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
65393002774	delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
65393002775	Glutamate binding site [chemical binding]; other site
65393002776	homodimer interface [polypeptide binding]; other site
65393002777	NAD binding site [chemical binding]; other site
65393002778	catalytic residues [active]
65393002779	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
65393002780	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
65393002781	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
65393002782	RNase E interface [polypeptide binding]; other site
65393002783	trimer interface [polypeptide binding]; other site
65393002784	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
65393002785	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
65393002786	RNase E interface [polypeptide binding]; other site
65393002787	trimer interface [polypeptide binding]; other site
65393002788	active site
65393002789	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
65393002790	putative nucleic acid binding region [nucleotide binding]; other site
65393002791	G-X-X-G motif; other site
65393002792	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
65393002793	RNA binding site [nucleotide binding]; other site
65393002794	domain interface; other site
65393002795	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
65393002796	Putative transcription activator [Transcription]; Region: TenA; COG0819
65393002797	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
65393002798	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393002799	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393002800	active site
65393002801	ATP binding site [chemical binding]; other site
65393002802	substrate binding site [chemical binding]; other site
65393002803	activation loop (A-loop); other site
65393002804	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393002805	Ligand Binding Site [chemical binding]; other site
65393002806	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393002807	Ligand Binding Site [chemical binding]; other site
65393002808	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
65393002809	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
65393002810	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
65393002811	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
65393002812	tetramer (dimer of dimers) interface [polypeptide binding]; other site
65393002813	active site
65393002814	dimer interface [polypeptide binding]; other site
65393002815	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
65393002816	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393002817	Coenzyme A binding pocket [chemical binding]; other site
65393002818	Methyltransferase domain; Region: Methyltransf_24; pfam13578
65393002819	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
65393002820	L11 interface [polypeptide binding]; other site
65393002821	putative EF-Tu interaction site [polypeptide binding]; other site
65393002822	putative EF-G interaction site [polypeptide binding]; other site
65393002823	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
65393002824	23S rRNA interface [nucleotide binding]; other site
65393002825	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
65393002826	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
65393002827	mRNA/rRNA interface [nucleotide binding]; other site
65393002828	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
65393002829	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
65393002830	23S rRNA interface [nucleotide binding]; other site
65393002831	L7/L12 interface [polypeptide binding]; other site
65393002832	putative thiostrepton binding site; other site
65393002833	L25 interface [polypeptide binding]; other site
65393002834	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
65393002835	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
65393002836	putative homodimer interface [polypeptide binding]; other site
65393002837	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
65393002838	heterodimer interface [polypeptide binding]; other site
65393002839	homodimer interface [polypeptide binding]; other site
65393002840	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
65393002841	ribosomal protein L19; Region: rpl19; CHL00084
65393002842	Integral membrane protein TerC family; Region: TerC; cl10468
65393002843	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65393002844	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393002845	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393002846	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65393002847	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393002848	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393002849	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393002850	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393002851	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393002852	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
65393002853	Protein export membrane protein; Region: SecD_SecF; pfam02355
65393002854	protein-export membrane protein SecD; Region: secD; TIGR01129
65393002855	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
65393002856	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
65393002857	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
65393002858	alpha subunit interface [polypeptide binding]; other site
65393002859	TPP binding site [chemical binding]; other site
65393002860	heterodimer interface [polypeptide binding]; other site
65393002861	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
65393002862	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
65393002863	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
65393002864	MOSC domain; Region: MOSC; pfam03473
65393002865	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
65393002866	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
65393002867	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393002868	ATP binding site [chemical binding]; other site
65393002869	putative Mg++ binding site [ion binding]; other site
65393002870	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65393002871	nucleotide binding region [chemical binding]; other site
65393002872	ATP-binding site [chemical binding]; other site
65393002873	cytochrome b6-f complex subunit PetN; Provisional; Region: PRK14747
65393002874	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
65393002875	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393002876	Circadian oscillating protein COP23; Region: COP23; pfam14218
65393002877	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
65393002878	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
65393002879	putative phosphate acyltransferase; Provisional; Region: PRK05331
65393002880	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
65393002881	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
65393002882	dimer interface [polypeptide binding]; other site
65393002883	active site
65393002884	CoA binding pocket [chemical binding]; other site
65393002885	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
65393002886	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
65393002887	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65393002888	active site
65393002889	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
65393002890	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
65393002891	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
65393002892	protein I interface; other site
65393002893	D2 interface; other site
65393002894	protein T interface; other site
65393002895	chlorophyll binding site; other site
65393002896	beta carotene binding site; other site
65393002897	pheophytin binding site; other site
65393002898	manganese-stabilizing polypeptide interface; other site
65393002899	CP43 interface; other site
65393002900	protein L interface; other site
65393002901	oxygen evolving complex binding site; other site
65393002902	bromide binding site; other site
65393002903	quinone binding site; other site
65393002904	Fe binding site [ion binding]; other site
65393002905	core light harvesting interface; other site
65393002906	cytochrome b559 alpha subunit interface; other site
65393002907	cytochrome c-550 interface; other site
65393002908	protein J interface; other site
65393002909	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393002910	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393002911	putative active site [active]
65393002912	Caspase domain; Region: Peptidase_C14; pfam00656
65393002913	GUN4-like; Region: GUN4; pfam05419
65393002914	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
65393002915	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
65393002916	putative active site [active]
65393002917	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
65393002918	short chain dehydrogenase; Provisional; Region: PRK06701
65393002919	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
65393002920	NAD binding site [chemical binding]; other site
65393002921	metal binding site [ion binding]; metal-binding site
65393002922	active site
65393002923	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
65393002924	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
65393002925	homodimer interface [polypeptide binding]; other site
65393002926	Walker A motif; other site
65393002927	ATP binding site [chemical binding]; other site
65393002928	hydroxycobalamin binding site [chemical binding]; other site
65393002929	Walker B motif; other site
65393002930	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
65393002931	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
65393002932	Ligand Binding Site [chemical binding]; other site
65393002933	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
65393002934	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
65393002935	Surface antigen; Region: Bac_surface_Ag; pfam01103
65393002936	haemagglutination activity domain; Region: Haemagg_act; pfam05860
65393002937	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
65393002938	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
65393002939	Protein of unknown function (DUF952); Region: DUF952; pfam06108
65393002940	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
65393002941	Major Facilitator Superfamily; Region: MFS_1; pfam07690
65393002942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393002943	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
65393002944	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
65393002945	MgtC family; Region: MgtC; pfam02308
65393002946	Dam-replacing family; Region: DRP; pfam06044
65393002947	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
65393002948	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
65393002949	dimerization interface [polypeptide binding]; other site
65393002950	DPS ferroxidase diiron center [ion binding]; other site
65393002951	ion pore; other site
65393002952	ChaB; Region: ChaB; pfam06150
65393002953	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
65393002954	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65393002955	homoserine kinase; Provisional; Region: PRK01212
65393002956	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
65393002957	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
65393002958	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393002959	PAS fold; Region: PAS_3; pfam08447
65393002960	putative active site [active]
65393002961	heme pocket [chemical binding]; other site
65393002962	PAS fold; Region: PAS_4; pfam08448
65393002963	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393002964	putative active site [active]
65393002965	heme pocket [chemical binding]; other site
65393002966	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393002967	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393002968	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
65393002969	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393002970	putative active site [active]
65393002971	heme pocket [chemical binding]; other site
65393002972	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393002973	dimer interface [polypeptide binding]; other site
65393002974	phosphorylation site [posttranslational modification]
65393002975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393002976	ATP binding site [chemical binding]; other site
65393002977	Mg2+ binding site [ion binding]; other site
65393002978	G-X-G motif; other site
65393002979	Response regulator receiver domain; Region: Response_reg; pfam00072
65393002980	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393002981	active site
65393002982	phosphorylation site [posttranslational modification]
65393002983	intermolecular recognition site; other site
65393002984	dimerization interface [polypeptide binding]; other site
65393002985	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
65393002986	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393002987	PAS domain; Region: PAS_9; pfam13426
65393002988	putative active site [active]
65393002989	heme pocket [chemical binding]; other site
65393002990	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393002991	PAS domain; Region: PAS_9; pfam13426
65393002992	putative active site [active]
65393002993	heme pocket [chemical binding]; other site
65393002994	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393002995	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393002996	metal binding site [ion binding]; metal-binding site
65393002997	active site
65393002998	I-site; other site
65393002999	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393003000	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
65393003001	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
65393003002	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003003	TPR motif; other site
65393003004	TPR repeat; Region: TPR_11; pfam13414
65393003005	binding surface
65393003006	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65393003007	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65393003008	catalytic loop [active]
65393003009	iron binding site [ion binding]; other site
65393003010	Phycobilisome protein; Region: Phycobilisome; cl08227
65393003011	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65393003012	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65393003013	catalytic loop [active]
65393003014	iron binding site [ion binding]; other site
65393003015	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
65393003016	V4R domain; Region: V4R; pfam02830
65393003017	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
65393003018	V4R domain; Region: V4R; pfam02830
65393003019	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
65393003020	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
65393003021	putative NAD(P) binding site [chemical binding]; other site
65393003022	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
65393003023	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65393003024	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
65393003025	active site clefts [active]
65393003026	zinc binding site [ion binding]; other site
65393003027	dimer interface [polypeptide binding]; other site
65393003028	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
65393003029	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65393003030	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
65393003031	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
65393003032	Fasciclin domain; Region: Fasciclin; pfam02469
65393003033	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
65393003034	EamA-like transporter family; Region: EamA; pfam00892
65393003035	EamA-like transporter family; Region: EamA; pfam00892
65393003036	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
65393003037	lipoyl synthase; Provisional; Region: PRK12928
65393003038	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393003039	FeS/SAM binding site; other site
65393003040	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
65393003041	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
65393003042	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
65393003043	TM-ABC transporter signature motif; other site
65393003044	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
65393003045	FOG: CBS domain [General function prediction only]; Region: COG0517
65393003046	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65393003047	FOG: CBS domain [General function prediction only]; Region: COG0517
65393003048	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
65393003049	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65393003050	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393003051	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393003052	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
65393003053	Histidine kinase; Region: HisKA_2; pfam07568
65393003054	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393003055	ATP binding site [chemical binding]; other site
65393003056	Mg2+ binding site [ion binding]; other site
65393003057	G-X-G motif; other site
65393003058	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393003059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393003060	active site
65393003061	phosphorylation site [posttranslational modification]
65393003062	intermolecular recognition site; other site
65393003063	dimerization interface [polypeptide binding]; other site
65393003064	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393003065	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393003066	dimer interface [polypeptide binding]; other site
65393003067	phosphorylation site [posttranslational modification]
65393003068	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393003069	ATP binding site [chemical binding]; other site
65393003070	Mg2+ binding site [ion binding]; other site
65393003071	G-X-G motif; other site
65393003072	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393003073	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393003074	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393003075	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393003076	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
65393003077	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
65393003078	NAD binding site [chemical binding]; other site
65393003079	ATP-grasp domain; Region: ATP-grasp; pfam02222
65393003080	GTP-binding protein LepA; Provisional; Region: PRK05433
65393003081	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
65393003082	G1 box; other site
65393003083	putative GEF interaction site [polypeptide binding]; other site
65393003084	GTP/Mg2+ binding site [chemical binding]; other site
65393003085	Switch I region; other site
65393003086	G2 box; other site
65393003087	G3 box; other site
65393003088	Switch II region; other site
65393003089	G4 box; other site
65393003090	G5 box; other site
65393003091	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
65393003092	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
65393003093	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
65393003094	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393003095	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393003096	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393003097	dimer interface [polypeptide binding]; other site
65393003098	phosphorylation site [posttranslational modification]
65393003099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393003100	ATP binding site [chemical binding]; other site
65393003101	Mg2+ binding site [ion binding]; other site
65393003102	G-X-G motif; other site
65393003103	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65393003104	active site
65393003105	S-layer homology domain; Region: SLH; pfam00395
65393003106	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
65393003107	nucleoside/Zn binding site; other site
65393003108	dimer interface [polypeptide binding]; other site
65393003109	catalytic motif [active]
65393003110	2-isopropylmalate synthase; Validated; Region: PRK00915
65393003111	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
65393003112	active site
65393003113	catalytic residues [active]
65393003114	metal binding site [ion binding]; metal-binding site
65393003115	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
65393003116	Maf-like protein; Region: Maf; pfam02545
65393003117	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
65393003118	active site
65393003119	dimer interface [polypeptide binding]; other site
65393003120	PsbP; Region: PsbP; pfam01789
65393003121	TPR repeat; Region: TPR_11; pfam13414
65393003122	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003123	binding surface
65393003124	TPR motif; other site
65393003125	TPR repeat; Region: TPR_11; pfam13414
65393003126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003127	binding surface
65393003128	TPR motif; other site
65393003129	TPR repeat; Region: TPR_11; pfam13414
65393003130	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
65393003131	active site
65393003132	catalytic site [active]
65393003133	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
65393003134	HEAT repeats; Region: HEAT_2; pfam13646
65393003135	HEAT repeats; Region: HEAT_2; pfam13646
65393003136	TIR domain; Region: TIR_2; pfam13676
65393003137	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
65393003138	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
65393003139	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
65393003140	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
65393003141	four helix bundle protein; Region: TIGR02436
65393003142	phage tail protein domain; Region: tail_TIGR02242
65393003143	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
65393003144	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
65393003145	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393003146	dimer interface [polypeptide binding]; other site
65393003147	phosphorylation site [posttranslational modification]
65393003148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393003149	ATP binding site [chemical binding]; other site
65393003150	Mg2+ binding site [ion binding]; other site
65393003151	G-X-G motif; other site
65393003152	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393003153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393003154	active site
65393003155	phosphorylation site [posttranslational modification]
65393003156	intermolecular recognition site; other site
65393003157	dimerization interface [polypeptide binding]; other site
65393003158	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393003159	DNA binding site [nucleotide binding]
65393003160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
65393003161	Predicted integral membrane protein [Function unknown]; Region: COG0392
65393003162	maltose O-acetyltransferase; Provisional; Region: PRK10092
65393003163	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
65393003164	active site
65393003165	substrate binding site [chemical binding]; other site
65393003166	trimer interface [polypeptide binding]; other site
65393003167	CoA binding site [chemical binding]; other site
65393003168	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
65393003169	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
65393003170	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
65393003171	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
65393003172	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393003173	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
65393003174	Coenzyme A binding pocket [chemical binding]; other site
65393003175	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
65393003176	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
65393003177	generic binding surface II; other site
65393003178	ssDNA binding site; other site
65393003179	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393003180	ATP binding site [chemical binding]; other site
65393003181	putative Mg++ binding site [ion binding]; other site
65393003182	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65393003183	nucleotide binding region [chemical binding]; other site
65393003184	ATP-binding site [chemical binding]; other site
65393003185	elongation factor Ts; Reviewed; Region: tsf; PRK12332
65393003186	UBA/TS-N domain; Region: UBA; pfam00627
65393003187	Elongation factor TS; Region: EF_TS; pfam00889
65393003188	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
65393003189	rRNA interaction site [nucleotide binding]; other site
65393003190	S8 interaction site; other site
65393003191	putative laminin-1 binding site; other site
65393003192	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
65393003193	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
65393003194	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393003195	FeS/SAM binding site; other site
65393003196	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
65393003197	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
65393003198	lipoyl attachment site [posttranslational modification]; other site
65393003199	phytoene desaturase; Region: phytoene_desat; TIGR02731
65393003200	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393003201	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
65393003202	active site lid residues [active]
65393003203	substrate binding pocket [chemical binding]; other site
65393003204	catalytic residues [active]
65393003205	substrate-Mg2+ binding site; other site
65393003206	aspartate-rich region 1; other site
65393003207	aspartate-rich region 2; other site
65393003208	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
65393003209	UbiA prenyltransferase family; Region: UbiA; pfam01040
65393003210	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
65393003211	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
65393003212	HD domain; Region: HD; pfam01966
65393003213	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
65393003214	active site residue [active]
65393003215	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
65393003216	Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969
65393003217	Predicted transcriptional regulators [Transcription]; Region: COG1695
65393003218	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
65393003219	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
65393003220	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65393003221	HlyD family secretion protein; Region: HlyD_3; pfam13437
65393003222	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
65393003223	Protein export membrane protein; Region: SecD_SecF; cl14618
65393003224	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
65393003225	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393003226	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393003227	structural tetrad; other site
65393003228	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393003229	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393003230	structural tetrad; other site
65393003231	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393003232	structural tetrad; other site
65393003233	TIR domain; Region: TIR_2; pfam13676
65393003234	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393003235	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65393003236	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
65393003237	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65393003238	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
65393003239	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
65393003240	putative acyl-acceptor binding pocket; other site
65393003241	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
65393003242	RNA methyltransferase, RsmE family; Region: TIGR00046
65393003243	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
65393003244	putative acyl transferase; Provisional; Region: PRK10502
65393003245	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
65393003246	putative trimer interface [polypeptide binding]; other site
65393003247	putative active site [active]
65393003248	putative substrate binding site [chemical binding]; other site
65393003249	putative CoA binding site [chemical binding]; other site
65393003250	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
65393003251	homotrimer interface [polypeptide binding]; other site
65393003252	Walker A motif; other site
65393003253	GTP binding site [chemical binding]; other site
65393003254	Walker B motif; other site
65393003255	ribonuclease Z; Region: RNase_Z; TIGR02651
65393003256	UGMP family protein; Validated; Region: PRK09604
65393003257	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
65393003258	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
65393003259	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
65393003260	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65393003261	active site
65393003262	catalytic tetrad [active]
65393003263	Dodecin; Region: Dodecin; cl01328
65393003264	Amidase; Region: Amidase; cl11426
65393003265	CheB methylesterase; Region: CheB_methylest; pfam01339
65393003266	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
65393003267	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
65393003268	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
65393003269	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
65393003270	PemK-like protein; Region: PemK; pfam02452
65393003271	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
65393003272	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
65393003273	Malic enzyme, N-terminal domain; Region: malic; pfam00390
65393003274	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
65393003275	putative NAD(P) binding site [chemical binding]; other site
65393003276	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
65393003277	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
65393003278	Uncharacterized conserved protein [Function unknown]; Region: COG4279
65393003279	SWIM zinc finger; Region: SWIM; pfam04434
65393003280	Domain of unknown function (DUF202); Region: DUF202; cl09954
65393003281	Domain of unknown function (DUF202); Region: DUF202; cl09954
65393003282	Domain of unknown function (DUF202); Region: DUF202; cl09954
65393003283	Sodium Bile acid symporter family; Region: SBF; cl17470
65393003284	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
65393003285	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
65393003286	Sulfatase; Region: Sulfatase; pfam00884
65393003287	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
65393003288	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
65393003289	Uncharacterized conserved protein [Function unknown]; Region: COG1262
65393003290	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
65393003291	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
65393003292	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
65393003293	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393003294	putative active site [active]
65393003295	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
65393003296	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
65393003297	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
65393003298	RNA binding site [nucleotide binding]; other site
65393003299	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
65393003300	RNA binding site [nucleotide binding]; other site
65393003301	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
65393003302	RNA binding site [nucleotide binding]; other site
65393003303	Dienelactone hydrolase family; Region: DLH; pfam01738
65393003304	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
65393003305	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
65393003306	dimerization interface [polypeptide binding]; other site
65393003307	active site
65393003308	dihydroorotase; Provisional; Region: PRK07369
65393003309	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
65393003310	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
65393003311	active site
65393003312	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
65393003313	uridine phosphorylase; Provisional; Region: PRK11178
65393003314	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
65393003315	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
65393003316	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
65393003317	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
65393003318	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393003319	Walker A/P-loop; other site
65393003320	ATP binding site [chemical binding]; other site
65393003321	Q-loop/lid; other site
65393003322	ABC transporter signature motif; other site
65393003323	Walker B; other site
65393003324	D-loop; other site
65393003325	H-loop/switch region; other site
65393003326	TOBE domain; Region: TOBE_2; pfam08402
65393003327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393003328	dimer interface [polypeptide binding]; other site
65393003329	ABC-ATPase subunit interface; other site
65393003330	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
65393003331	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393003332	Probable transposase; Region: OrfB_IS605; pfam01385
65393003333	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393003334	glycogen branching enzyme; Provisional; Region: PRK05402
65393003335	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
65393003336	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
65393003337	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
65393003338	active site
65393003339	catalytic site [active]
65393003340	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
65393003341	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
65393003342	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
65393003343	substrate binding pocket [chemical binding]; other site
65393003344	chain length determination region; other site
65393003345	substrate-Mg2+ binding site; other site
65393003346	catalytic residues [active]
65393003347	aspartate-rich region 1; other site
65393003348	active site lid residues [active]
65393003349	aspartate-rich region 2; other site
65393003350	Exoribonuclease R [Transcription]; Region: VacB; COG0557
65393003351	RNB domain; Region: RNB; pfam00773
65393003352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393003353	S-adenosylmethionine binding site [chemical binding]; other site
65393003354	AAA ATPase domain; Region: AAA_16; pfam13191
65393003355	NB-ARC domain; Region: NB-ARC; pfam00931
65393003356	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393003357	structural tetrad; other site
65393003358	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393003359	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393003360	structural tetrad; other site
65393003361	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393003362	structural tetrad; other site
65393003363	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
65393003364	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
65393003365	[2Fe-2S] cluster binding site [ion binding]; other site
65393003366	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
65393003367	hydrophobic ligand binding site; other site
65393003368	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
65393003369	UbiA prenyltransferase family; Region: UbiA; pfam01040
65393003370	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
65393003371	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
65393003372	P loop; other site
65393003373	Nucleotide binding site [chemical binding]; other site
65393003374	DTAP/Switch II; other site
65393003375	Switch I; other site
65393003376	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
65393003377	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
65393003378	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
65393003379	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
65393003380	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
65393003381	Walker A/P-loop; other site
65393003382	ATP binding site [chemical binding]; other site
65393003383	Q-loop/lid; other site
65393003384	ABC transporter signature motif; other site
65393003385	Walker B; other site
65393003386	D-loop; other site
65393003387	H-loop/switch region; other site
65393003388	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393003389	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393003390	hypothetical protein; Provisional; Region: PHA03169
65393003391	hypothetical protein; Provisional; Region: PHA03169
65393003392	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393003393	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393003394	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393003395	Uncharacterized conserved protein [Function unknown]; Region: COG5464
65393003396	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
65393003397	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
65393003398	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393003399	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393003400	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393003401	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393003402	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393003403	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
65393003404	putative ADP-binding pocket [chemical binding]; other site
65393003405	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393003406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
65393003407	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65393003408	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65393003409	active site
65393003410	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393003411	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65393003412	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
65393003413	Probable Catalytic site; other site
65393003414	metal-binding site
65393003415	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65393003416	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
65393003417	Probable Catalytic site; other site
65393003418	metal-binding site
65393003419	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393003420	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
65393003421	putative ADP-binding pocket [chemical binding]; other site
65393003422	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
65393003423	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
65393003424	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
65393003425	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
65393003426	TPR repeat; Region: TPR_11; pfam13414
65393003427	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003428	binding surface
65393003429	TPR motif; other site
65393003430	TPR repeat; Region: TPR_11; pfam13414
65393003431	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
65393003432	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393003433	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393003434	active site
65393003435	ATP binding site [chemical binding]; other site
65393003436	substrate binding site [chemical binding]; other site
65393003437	activation loop (A-loop); other site
65393003438	Domain of unknown function (DUF3859); Region: DUF3859; pfam12975
65393003439	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393003440	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393003441	active site
65393003442	ATP binding site [chemical binding]; other site
65393003443	substrate binding site [chemical binding]; other site
65393003444	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
65393003445	substrate binding site [chemical binding]; other site
65393003446	activation loop (A-loop); other site
65393003447	activation loop (A-loop); other site
65393003448	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
65393003449	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
65393003450	dimer interface [polypeptide binding]; other site
65393003451	PYR/PP interface [polypeptide binding]; other site
65393003452	TPP binding site [chemical binding]; other site
65393003453	substrate binding site [chemical binding]; other site
65393003454	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
65393003455	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
65393003456	Domain of unknown function; Region: EKR; pfam10371
65393003457	4Fe-4S binding domain; Region: Fer4_6; pfam12837
65393003458	4Fe-4S binding domain; Region: Fer4; pfam00037
65393003459	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
65393003460	TPP-binding site [chemical binding]; other site
65393003461	dimer interface [polypeptide binding]; other site
65393003462	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
65393003463	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
65393003464	putative active site [active]
65393003465	putative FMN binding site [chemical binding]; other site
65393003466	putative substrate binding site [chemical binding]; other site
65393003467	6-phosphofructokinase; Provisional; Region: PRK03202
65393003468	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
65393003469	active site
65393003470	ADP/pyrophosphate binding site [chemical binding]; other site
65393003471	dimerization interface [polypeptide binding]; other site
65393003472	allosteric effector site; other site
65393003473	fructose-1,6-bisphosphate binding site; other site
65393003474	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
65393003475	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
65393003476	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
65393003477	active site
65393003478	hydrophilic channel; other site
65393003479	dimerization interface [polypeptide binding]; other site
65393003480	catalytic residues [active]
65393003481	active site lid [active]
65393003482	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
65393003483	Predicted permease [General function prediction only]; Region: COG3329
65393003484	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
65393003485	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
65393003486	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
65393003487	DNA binding residues [nucleotide binding]
65393003488	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
65393003489	catalytic residues [active]
65393003490	catalytic nucleophile [active]
65393003491	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
65393003492	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
65393003493	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393003494	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393003495	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393003496	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393003497	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393003498	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393003499	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393003500	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
65393003501	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
65393003502	Walker A/P-loop; other site
65393003503	ATP binding site [chemical binding]; other site
65393003504	Q-loop/lid; other site
65393003505	ABC transporter signature motif; other site
65393003506	Walker B; other site
65393003507	D-loop; other site
65393003508	H-loop/switch region; other site
65393003509	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
65393003510	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
65393003511	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
65393003512	Walker A/P-loop; other site
65393003513	ATP binding site [chemical binding]; other site
65393003514	Q-loop/lid; other site
65393003515	ABC transporter signature motif; other site
65393003516	Walker B; other site
65393003517	D-loop; other site
65393003518	H-loop/switch region; other site
65393003519	TOBE domain; Region: TOBE_2; pfam08402
65393003520	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
65393003521	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
65393003522	polyphosphate kinase; Provisional; Region: PRK05443
65393003523	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
65393003524	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
65393003525	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
65393003526	putative domain interface [polypeptide binding]; other site
65393003527	putative active site [active]
65393003528	catalytic site [active]
65393003529	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
65393003530	putative domain interface [polypeptide binding]; other site
65393003531	putative active site [active]
65393003532	catalytic site [active]
65393003533	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
65393003534	metal ion-dependent adhesion site (MIDAS); other site
65393003535	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
65393003536	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
65393003537	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
65393003538	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393003539	Walker A/P-loop; other site
65393003540	ATP binding site [chemical binding]; other site
65393003541	Q-loop/lid; other site
65393003542	ABC transporter signature motif; other site
65393003543	Walker B; other site
65393003544	D-loop; other site
65393003545	H-loop/switch region; other site
65393003546	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393003547	PAS fold; Region: PAS_3; pfam08447
65393003548	putative active site [active]
65393003549	heme pocket [chemical binding]; other site
65393003550	PAS domain S-box; Region: sensory_box; TIGR00229
65393003551	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393003552	putative active site [active]
65393003553	heme pocket [chemical binding]; other site
65393003554	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393003555	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393003556	metal binding site [ion binding]; metal-binding site
65393003557	active site
65393003558	I-site; other site
65393003559	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393003560	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
65393003561	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003562	TPR motif; other site
65393003563	binding surface
65393003564	BAF1 / ABF1 chromatin reorganising factor; Region: BAF1_ABF1; pfam04684
65393003565	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
65393003566	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003567	binding surface
65393003568	TPR motif; other site
65393003569	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393003570	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003571	binding surface
65393003572	TPR motif; other site
65393003573	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393003574	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003575	binding surface
65393003576	TPR motif; other site
65393003577	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393003578	sulfotransferase; Region: PLN02164
65393003579	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393003580	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
65393003581	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
65393003582	active site
65393003583	HIGH motif; other site
65393003584	dimer interface [polypeptide binding]; other site
65393003585	KMSKS motif; other site
65393003586	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
65393003587	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
65393003588	active site
65393003589	integral membrane protein MviN; Region: mviN; TIGR01695
65393003590	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
65393003591	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
65393003592	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393003593	dimer interface [polypeptide binding]; other site
65393003594	phosphorylation site [posttranslational modification]
65393003595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393003596	ATP binding site [chemical binding]; other site
65393003597	Mg2+ binding site [ion binding]; other site
65393003598	G-X-G motif; other site
65393003599	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
65393003600	putative active site [active]
65393003601	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
65393003602	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
65393003603	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
65393003604	homotrimer interaction site [polypeptide binding]; other site
65393003605	putative active site [active]
65393003606	Uncharacterized conserved protein [Function unknown]; Region: COG0432
65393003607	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
65393003608	TPR repeat; Region: TPR_11; pfam13414
65393003609	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
65393003610	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
65393003611	putative ligand binding site [chemical binding]; other site
65393003612	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
65393003613	Beta-lactamase; Region: Beta-lactamase; pfam00144
65393003614	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
65393003615	Ion channel; Region: Ion_trans_2; pfam07885
65393003616	Late 100kD protein; Region: Adeno_100; pfam02438
65393003617	Predicted membrane protein [Function unknown]; Region: COG2323
65393003618	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
65393003619	NYN domain; Region: NYN; pfam01936
65393003620	putative metal binding site [ion binding]; other site
65393003621	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
65393003622	Ligand Binding Site [chemical binding]; other site
65393003623	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393003624	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
65393003625	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393003626	FeS/SAM binding site; other site
65393003627	Protein of function (DUF2518); Region: DUF2518; pfam10726
65393003628	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
65393003629	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
65393003630	putative active site [active]
65393003631	metal binding site [ion binding]; metal-binding site
65393003632	hypothetical protein; Reviewed; Region: PRK12497
65393003633	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
65393003634	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
65393003635	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
65393003636	G1 box; other site
65393003637	GTP/Mg2+ binding site [chemical binding]; other site
65393003638	Switch I region; other site
65393003639	G2 box; other site
65393003640	Switch II region; other site
65393003641	G3 box; other site
65393003642	G4 box; other site
65393003643	G5 box; other site
65393003644	Domain of unknown function (DUF697); Region: DUF697; pfam05128
65393003645	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
65393003646	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393003647	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393003648	metal binding site [ion binding]; metal-binding site
65393003649	active site
65393003650	I-site; other site
65393003651	Uncharacterized conserved protein [Function unknown]; Region: COG3339
65393003652	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393003653	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393003654	Probable transposase; Region: OrfB_IS605; pfam01385
65393003655	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
65393003656	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65393003657	OsmC-like protein; Region: OsmC; cl00767
65393003658	replicative DNA helicase; Region: DnaB; TIGR00665
65393003659	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
65393003660	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
65393003661	Walker A motif; other site
65393003662	ATP binding site [chemical binding]; other site
65393003663	Walker B motif; other site
65393003664	DNA binding loops [nucleotide binding]
65393003665	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65393003666	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
65393003667	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
65393003668	DXD motif; other site
65393003669	PilZ domain; Region: PilZ; pfam07238
65393003670	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393003671	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393003672	active site
65393003673	ATP binding site [chemical binding]; other site
65393003674	substrate binding site [chemical binding]; other site
65393003675	activation loop (A-loop); other site
65393003676	RDD family; Region: RDD; pfam06271
65393003677	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393003678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393003679	active site
65393003680	phosphorylation site [posttranslational modification]
65393003681	intermolecular recognition site; other site
65393003682	dimerization interface [polypeptide binding]; other site
65393003683	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393003684	DNA binding site [nucleotide binding]
65393003685	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393003686	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393003687	Probable transposase; Region: OrfB_IS605; pfam01385
65393003688	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393003689	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
65393003690	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
65393003691	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
65393003692	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
65393003693	active site
65393003694	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
65393003695	Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002
65393003696	Predicted integral membrane protein [Function unknown]; Region: COG5637
65393003697	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
65393003698	putative hydrophobic ligand binding site [chemical binding]; other site
65393003699	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
65393003700	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
65393003701	NAD binding site [chemical binding]; other site
65393003702	catalytic Zn binding site [ion binding]; other site
65393003703	structural Zn binding site [ion binding]; other site
65393003704	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
65393003705	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
65393003706	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65393003707	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393003708	S-adenosylmethionine binding site [chemical binding]; other site
65393003709	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
65393003710	MltA specific insert domain; Region: MltA; pfam03562
65393003711	3D domain; Region: 3D; pfam06725
65393003712	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393003713	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003714	TPR repeat; Region: TPR_11; pfam13414
65393003715	binding surface
65393003716	TPR motif; other site
65393003717	TPR repeat; Region: TPR_11; pfam13414
65393003718	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003719	binding surface
65393003720	TPR motif; other site
65393003721	TPR repeat; Region: TPR_11; pfam13414
65393003722	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
65393003723	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003724	binding surface
65393003725	TPR motif; other site
65393003726	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003727	binding surface
65393003728	TPR motif; other site
65393003729	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
65393003730	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003731	binding surface
65393003732	TPR motif; other site
65393003733	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003734	binding surface
65393003735	TPR motif; other site
65393003736	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
65393003737	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003738	binding surface
65393003739	TPR motif; other site
65393003740	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003741	binding surface
65393003742	TPR motif; other site
65393003743	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393003744	binding surface
65393003745	TPR motif; other site
65393003746	CHAT domain; Region: CHAT; pfam12770
65393003747	Protein of unknown function (DUF433); Region: DUF433; pfam04255
65393003748	Protein of unknown function DUF82; Region: DUF82; pfam01927
65393003749	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393003750	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
65393003751	multimerization interface [polypeptide binding]; other site
65393003752	RbcX protein; Region: RcbX; pfam02341
65393003753	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
65393003754	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
65393003755	homodimer interface [polypeptide binding]; other site
65393003756	active site
65393003757	heterodimer interface [polypeptide binding]; other site
65393003758	catalytic residue [active]
65393003759	metal binding site [ion binding]; metal-binding site
65393003760	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
65393003761	putative trimer interface [polypeptide binding]; other site
65393003762	putative CoA binding site [chemical binding]; other site
65393003763	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
65393003764	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
65393003765	trimer interface [polypeptide binding]; other site
65393003766	active site
65393003767	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
65393003768	putative multimerization interface [polypeptide binding]; other site
65393003769	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
65393003770	putative multimerization interface [polypeptide binding]; other site
65393003771	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
65393003772	putative multimerization interface [polypeptide binding]; other site
65393003773	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
65393003774	putative multimerization interface [polypeptide binding]; other site
65393003775	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
65393003776	Hexamer/Pentamer interface [polypeptide binding]; other site
65393003777	central pore; other site
65393003778	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65393003779	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
65393003780	Hexamer interface [polypeptide binding]; other site
65393003781	Hexagonal pore residue; other site
65393003782	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65393003783	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
65393003784	Hexamer interface [polypeptide binding]; other site
65393003785	Hexagonal pore residue; other site
65393003786	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65393003787	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
65393003788	Hexamer interface [polypeptide binding]; other site
65393003789	Hexagonal pore residue; other site
65393003790	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
65393003791	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65393003792	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
65393003793	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65393003794	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
65393003795	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393003796	putative active site [active]
65393003797	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
65393003798	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
65393003799	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
65393003800	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
65393003801	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
65393003802	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
65393003803	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
65393003804	active site
65393003805	dimer interface [polypeptide binding]; other site
65393003806	motif 1; other site
65393003807	motif 2; other site
65393003808	motif 3; other site
65393003809	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
65393003810	anticodon binding site; other site
65393003811	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
65393003812	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65393003813	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393003814	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
65393003815	Walker A/P-loop; other site
65393003816	ATP binding site [chemical binding]; other site
65393003817	Q-loop/lid; other site
65393003818	ABC transporter signature motif; other site
65393003819	Walker B; other site
65393003820	D-loop; other site
65393003821	H-loop/switch region; other site
65393003822	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
65393003823	RimM N-terminal domain; Region: RimM; pfam01782
65393003824	PRC-barrel domain; Region: PRC; pfam05239
65393003825	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
65393003826	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
65393003827	HEAT repeats; Region: HEAT_2; pfam13646
65393003828	HEAT repeats; Region: HEAT_2; pfam13646
65393003829	HEAT repeats; Region: HEAT_2; pfam13646
65393003830	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
65393003831	Fe-S cluster binding site [ion binding]; other site
65393003832	active site
65393003833	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
65393003834	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
65393003835	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
65393003836	ligand binding site [chemical binding]; other site
65393003837	homodimer interface [polypeptide binding]; other site
65393003838	NAD(P) binding site [chemical binding]; other site
65393003839	trimer interface B [polypeptide binding]; other site
65393003840	trimer interface A [polypeptide binding]; other site
65393003841	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
65393003842	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
65393003843	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
65393003844	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
65393003845	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
65393003846	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
65393003847	putative catalytic residues [active]
65393003848	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
65393003849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
65393003850	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
65393003851	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
65393003852	CHASE2 domain; Region: CHASE2; pfam05226
65393003853	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
65393003854	cyclase homology domain; Region: CHD; cd07302
65393003855	nucleotidyl binding site; other site
65393003856	metal binding site [ion binding]; metal-binding site
65393003857	dimer interface [polypeptide binding]; other site
65393003858	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
65393003859	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393003860	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65393003861	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393003862	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65393003863	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393003864	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65393003865	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393003866	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
65393003867	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
65393003868	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
65393003869	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393003870	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65393003871	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393003872	DNA binding residues [nucleotide binding]
65393003873	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65393003874	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393003875	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393003876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393003877	active site
65393003878	phosphorylation site [posttranslational modification]
65393003879	intermolecular recognition site; other site
65393003880	dimerization interface [polypeptide binding]; other site
65393003881	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393003882	DNA binding residues [nucleotide binding]
65393003883	dimerization interface [polypeptide binding]; other site
65393003884	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393003885	PAS domain; Region: PAS_9; pfam13426
65393003886	putative active site [active]
65393003887	heme pocket [chemical binding]; other site
65393003888	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393003889	PAS fold; Region: PAS_3; pfam08447
65393003890	putative active site [active]
65393003891	heme pocket [chemical binding]; other site
65393003892	PAS domain S-box; Region: sensory_box; TIGR00229
65393003893	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393003894	putative active site [active]
65393003895	heme pocket [chemical binding]; other site
65393003896	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393003897	dimer interface [polypeptide binding]; other site
65393003898	phosphorylation site [posttranslational modification]
65393003899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393003900	ATP binding site [chemical binding]; other site
65393003901	Mg2+ binding site [ion binding]; other site
65393003902	G-X-G motif; other site
65393003903	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393003904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393003905	active site
65393003906	phosphorylation site [posttranslational modification]
65393003907	intermolecular recognition site; other site
65393003908	dimerization interface [polypeptide binding]; other site
65393003909	Response regulator receiver domain; Region: Response_reg; pfam00072
65393003910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393003911	active site
65393003912	phosphorylation site [posttranslational modification]
65393003913	intermolecular recognition site; other site
65393003914	dimerization interface [polypeptide binding]; other site
65393003915	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393003916	dimer interface [polypeptide binding]; other site
65393003917	phosphorylation site [posttranslational modification]
65393003918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393003919	ATP binding site [chemical binding]; other site
65393003920	Mg2+ binding site [ion binding]; other site
65393003921	G-X-G motif; other site
65393003922	Response regulator receiver domain; Region: Response_reg; pfam00072
65393003923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393003924	active site
65393003925	phosphorylation site [posttranslational modification]
65393003926	intermolecular recognition site; other site
65393003927	dimerization interface [polypeptide binding]; other site
65393003928	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393003929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393003930	ATP binding site [chemical binding]; other site
65393003931	Mg2+ binding site [ion binding]; other site
65393003932	G-X-G motif; other site
65393003933	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
65393003934	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393003935	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
65393003936	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
65393003937	active site
65393003938	dimer interface [polypeptide binding]; other site
65393003939	catalytic residue [active]
65393003940	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
65393003941	Ca2+ binding site [ion binding]; other site
65393003942	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
65393003943	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
65393003944	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393003945	ATP binding site [chemical binding]; other site
65393003946	putative Mg++ binding site [ion binding]; other site
65393003947	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65393003948	nucleotide binding region [chemical binding]; other site
65393003949	ATP-binding site [chemical binding]; other site
65393003950	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
65393003951	HRDC domain; Region: HRDC; pfam00570
65393003952	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
65393003953	DNA binding residues [nucleotide binding]
65393003954	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
65393003955	homooctamer interface [polypeptide binding]; other site
65393003956	active site
65393003957	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
65393003958	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65393003959	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393003960	putative active site [active]
65393003961	FO synthase subunit 2; Reviewed; Region: PRK07360
65393003962	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393003963	FeS/SAM binding site; other site
65393003964	GxxExxY protein; Region: GxxExxY; TIGR04256
65393003965	magnesium chelatase subunit H; Provisional; Region: PRK12493
65393003966	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
65393003967	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
65393003968	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393003969	putative active site [active]
65393003970	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
65393003971	Uncharacterized conserved protein [Function unknown]; Region: COG3791
65393003972	Rrf2 family protein; Region: rrf2_super; TIGR00738
65393003973	Transcriptional regulator; Region: Rrf2; pfam02082
65393003974	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
65393003975	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
65393003976	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
65393003977	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
65393003978	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
65393003979	TrkA-N domain; Region: TrkA_N; pfam02254
65393003980	NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180
65393003981	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
65393003982	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
65393003983	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65393003984	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
65393003985	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393003986	Coenzyme A binding pocket [chemical binding]; other site
65393003987	Tic22-like family; Region: Tic22; cl04468
65393003988	Tic22-like family; Region: Tic22; cl04468
65393003989	Tic22-like family; Region: Tic22; pfam04278
65393003990	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
65393003991	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
65393003992	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
65393003993	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
65393003994	putative valine binding site [chemical binding]; other site
65393003995	dimer interface [polypeptide binding]; other site
65393003996	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
65393003997	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393003998	GAF domain; Region: GAF; pfam01590
65393003999	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393004000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393004001	dimer interface [polypeptide binding]; other site
65393004002	phosphorylation site [posttranslational modification]
65393004003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393004004	ATP binding site [chemical binding]; other site
65393004005	Mg2+ binding site [ion binding]; other site
65393004006	G-X-G motif; other site
65393004007	Response regulator receiver domain; Region: Response_reg; pfam00072
65393004008	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393004009	active site
65393004010	phosphorylation site [posttranslational modification]
65393004011	intermolecular recognition site; other site
65393004012	dimerization interface [polypeptide binding]; other site
65393004013	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
65393004014	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
65393004015	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
65393004016	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
65393004017	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65393004018	non-specific DNA binding site [nucleotide binding]; other site
65393004019	salt bridge; other site
65393004020	sequence-specific DNA binding site [nucleotide binding]; other site
65393004021	Domain of unknown function (DUF955); Region: DUF955; pfam06114
65393004022	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
65393004023	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
65393004024	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
65393004025	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
65393004026	active site
65393004027	dimer interface [polypeptide binding]; other site
65393004028	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
65393004029	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
65393004030	active site
65393004031	FMN binding site [chemical binding]; other site
65393004032	substrate binding site [chemical binding]; other site
65393004033	3Fe-4S cluster binding site [ion binding]; other site
65393004034	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
65393004035	domain interface; other site
65393004036	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
65393004037	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393004038	Probable transposase; Region: OrfB_IS605; pfam01385
65393004039	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
65393004040	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
65393004041	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
65393004042	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
65393004043	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
65393004044	hypothetical protein; Provisional; Region: PRK04194
65393004045	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
65393004046	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393004047	FeS/SAM binding site; other site
65393004048	putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930
65393004049	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393004050	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004051	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393004052	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004053	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
65393004054	LysR family transcriptional regulator; Provisional; Region: PRK14997
65393004055	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
65393004056	putative effector binding pocket; other site
65393004057	dimerization interface [polypeptide binding]; other site
65393004058	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
65393004059	CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704
65393004060	Putative restriction endonuclease; Region: Uma2; pfam05685
65393004061	putative active site [active]
65393004062	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
65393004063	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
65393004064	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
65393004065	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
65393004066	NADP binding site [chemical binding]; other site
65393004067	active site
65393004068	putative substrate binding site [chemical binding]; other site
65393004069	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
65393004070	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
65393004071	substrate binding site; other site
65393004072	metal-binding site
65393004073	Oligomer interface; other site
65393004074	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
65393004075	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
65393004076	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
65393004077	NAD binding site [chemical binding]; other site
65393004078	substrate binding site [chemical binding]; other site
65393004079	homodimer interface [polypeptide binding]; other site
65393004080	active site
65393004081	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
65393004082	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
65393004083	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393004084	putative active site [active]
65393004085	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
65393004086	AMP binding site [chemical binding]; other site
65393004087	metal binding site [ion binding]; metal-binding site
65393004088	active site
65393004089	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
65393004090	putative active site [active]
65393004091	transaldolase; Provisional; Region: PRK03903
65393004092	catalytic residue [active]
65393004093	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
65393004094	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
65393004095	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
65393004096	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
65393004097	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
65393004098	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
65393004099	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
65393004100	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
65393004101	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
65393004102	catalytic triad [active]
65393004103	S-layer homology domain; Region: SLH; pfam00395
65393004104	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
65393004105	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
65393004106	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
65393004107	dimer interface [polypeptide binding]; other site
65393004108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393004109	catalytic residue [active]
65393004110	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
65393004111	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65393004112	HSP70 interaction site [polypeptide binding]; other site
65393004113	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
65393004114	active site
65393004115	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
65393004116	active site
65393004117	Creatinine amidohydrolase; Region: Creatininase; pfam02633
65393004118	TIR domain; Region: TIR_2; pfam13676
65393004119	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
65393004120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393004121	Walker A/P-loop; other site
65393004122	ATP binding site [chemical binding]; other site
65393004123	TIR domain; Region: TIR_2; pfam13676
65393004124	TIR domain; Region: TIR_2; pfam13676
65393004125	WD domain, G-beta repeat; Region: WD40; pfam00400
65393004126	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393004127	structural tetrad; other site
65393004128	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393004129	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393004130	structural tetrad; other site
65393004131	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393004132	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
65393004133	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
65393004134	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
65393004135	ScpA/B protein; Region: ScpA_ScpB; pfam02616
65393004136	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
65393004137	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
65393004138	active site
65393004139	Substrate binding site; other site
65393004140	Mg++ binding site; other site
65393004141	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
65393004142	putative trimer interface [polypeptide binding]; other site
65393004143	putative CoA binding site [chemical binding]; other site
65393004144	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
65393004145	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
65393004146	RNA binding surface [nucleotide binding]; other site
65393004147	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
65393004148	active site
65393004149	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
65393004150	YciI-like protein; Reviewed; Region: PRK12864
65393004151	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
65393004152	anti sigma factor interaction site; other site
65393004153	regulatory phosphorylation site [posttranslational modification]; other site
65393004154	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
65393004155	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
65393004156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393004157	active site
65393004158	phosphorylation site [posttranslational modification]
65393004159	intermolecular recognition site; other site
65393004160	dimerization interface [polypeptide binding]; other site
65393004161	CheB methylesterase; Region: CheB_methylest; pfam01339
65393004162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393004163	active site
65393004164	phosphorylation site [posttranslational modification]
65393004165	intermolecular recognition site; other site
65393004166	dimerization interface [polypeptide binding]; other site
65393004167	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
65393004168	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
65393004169	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
65393004170	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65393004171	putative binding surface; other site
65393004172	active site
65393004173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393004174	ATP binding site [chemical binding]; other site
65393004175	Mg2+ binding site [ion binding]; other site
65393004176	G-X-G motif; other site
65393004177	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
65393004178	Response regulator receiver domain; Region: Response_reg; pfam00072
65393004179	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393004180	active site
65393004181	phosphorylation site [posttranslational modification]
65393004182	intermolecular recognition site; other site
65393004183	dimerization interface [polypeptide binding]; other site
65393004184	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
65393004185	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
65393004186	Part of AAA domain; Region: AAA_19; pfam13245
65393004187	Family description; Region: UvrD_C_2; pfam13538
65393004188	Predicted membrane protein [Function unknown]; Region: COG3463
65393004189	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
65393004190	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393004191	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393004192	prolyl-tRNA synthetase; Provisional; Region: PRK09194
65393004193	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
65393004194	dimer interface [polypeptide binding]; other site
65393004195	motif 1; other site
65393004196	active site
65393004197	motif 2; other site
65393004198	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
65393004199	putative deacylase active site [active]
65393004200	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
65393004201	active site
65393004202	motif 3; other site
65393004203	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
65393004204	anticodon binding site; other site
65393004205	Late competence development protein ComFB; Region: ComFB; pfam10719
65393004206	Late competence development protein ComFB; Region: ComFB; pfam10719
65393004207	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
65393004208	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
65393004209	putative active site [active]
65393004210	Zn binding site [ion binding]; other site
65393004211	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
65393004212	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
65393004213	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
65393004214	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65393004215	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
65393004216	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393004217	putative active site [active]
65393004218	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
65393004219	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65393004220	Cytochrome P450; Region: p450; pfam00067
65393004221	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
65393004222	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
65393004223	Cytochrome P450; Region: p450; pfam00067
65393004224	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
65393004225	Transposase; Region: DDE_Tnp_ISL3; pfam01610
65393004226	Predicted methyltransferases [General function prediction only]; Region: COG0313
65393004227	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
65393004228	putative SAM binding site [chemical binding]; other site
65393004229	putative homodimer interface [polypeptide binding]; other site
65393004230	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
65393004231	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
65393004232	substrate binding site [chemical binding]; other site
65393004233	ATP binding site [chemical binding]; other site
65393004234	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
65393004235	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004236	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393004237	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004238	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004239	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
65393004240	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
65393004241	active site
65393004242	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
65393004243	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
65393004244	GIY-YIG motif/motif A; other site
65393004245	active site
65393004246	catalytic site [active]
65393004247	putative DNA binding site [nucleotide binding]; other site
65393004248	metal binding site [ion binding]; metal-binding site
65393004249	UvrB/uvrC motif; Region: UVR; pfam02151
65393004250	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
65393004251	Helix-hairpin-helix motif; Region: HHH; pfam00633
65393004252	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
65393004253	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393004254	Walker A motif; other site
65393004255	ATP binding site [chemical binding]; other site
65393004256	Walker B motif; other site
65393004257	arginine finger; other site
65393004258	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
65393004259	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
65393004260	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
65393004261	substrate binding site [chemical binding]; other site
65393004262	glutamase interaction surface [polypeptide binding]; other site
65393004263	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
65393004264	catalytic triad [active]
65393004265	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
65393004266	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
65393004267	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
65393004268	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393004269	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
65393004270	protein binding site [polypeptide binding]; other site
65393004271	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393004272	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
65393004273	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
65393004274	NADP binding site [chemical binding]; other site
65393004275	active site
65393004276	putative substrate binding site [chemical binding]; other site
65393004277	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
65393004278	pheophytin binding site; other site
65393004279	chlorophyll binding site; other site
65393004280	quinone binding site; other site
65393004281	Fe binding site [ion binding]; other site
65393004282	TIR domain; Region: TIR_2; pfam13676
65393004283	Restriction endonuclease; Region: Mrr_cat; pfam04471
65393004284	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
65393004285	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
65393004286	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
65393004287	ThiS interaction site; other site
65393004288	putative active site [active]
65393004289	tetramer interface [polypeptide binding]; other site
65393004290	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
65393004291	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
65393004292	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
65393004293	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
65393004294	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
65393004295	photosystem II 47 kDa protein; Region: psbB; CHL00062
65393004296	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
65393004297	Nitrogen regulatory protein P-II; Region: P-II; smart00938
65393004298	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
65393004299	active site
65393004300	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
65393004301	RibD C-terminal domain; Region: RibD_C; cl17279
65393004302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
65393004303	Protein of unknown function, DUF482; Region: DUF482; pfam04339
65393004304	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
65393004305	trehalose synthase; Region: treS_nterm; TIGR02456
65393004306	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
65393004307	active site
65393004308	catalytic site [active]
65393004309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
65393004310	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
65393004311	Bacterial SH3 domain; Region: SH3_3; cl17532
65393004312	Uncharacterized conserved protein [Function unknown]; Region: COG0062
65393004313	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
65393004314	putative substrate binding site [chemical binding]; other site
65393004315	putative ATP binding site [chemical binding]; other site
65393004316	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
65393004317	Phosphoglycerate kinase; Region: PGK; pfam00162
65393004318	substrate binding site [chemical binding]; other site
65393004319	hinge regions; other site
65393004320	ADP binding site [chemical binding]; other site
65393004321	catalytic site [active]
65393004322	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393004323	Ligand Binding Site [chemical binding]; other site
65393004324	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
65393004325	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
65393004326	GTP/Mg2+ binding site [chemical binding]; other site
65393004327	G4 box; other site
65393004328	G5 box; other site
65393004329	G1 box; other site
65393004330	Switch I region; other site
65393004331	G2 box; other site
65393004332	G3 box; other site
65393004333	Switch II region; other site
65393004334	TIR domain; Region: TIR_2; pfam13676
65393004335	AAA domain; Region: AAA_33; pfam13671
65393004336	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
65393004337	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
65393004338	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
65393004339	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
65393004340	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
65393004341	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
65393004342	putative catalytic site [active]
65393004343	putative metal binding site [ion binding]; other site
65393004344	putative phosphate binding site [ion binding]; other site
65393004345	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
65393004346	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
65393004347	Competence protein; Region: Competence; pfam03772
65393004348	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
65393004349	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
65393004350	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
65393004351	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393004352	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
65393004353	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
65393004354	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
65393004355	NAD(P) binding site [chemical binding]; other site
65393004356	molecular chaperone DnaK; Provisional; Region: PRK13410
65393004357	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
65393004358	nucleotide binding site [chemical binding]; other site
65393004359	NEF interaction site [polypeptide binding]; other site
65393004360	SBD interface [polypeptide binding]; other site
65393004361	chaperone protein DnaJ; Provisional; Region: PRK14299
65393004362	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65393004363	HSP70 interaction site [polypeptide binding]; other site
65393004364	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
65393004365	dimer interface [polypeptide binding]; other site
65393004366	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
65393004367	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
65393004368	AAA domain; Region: AAA_23; pfam13476
65393004369	AAA domain; Region: AAA_21; pfam13304
65393004370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393004371	ABC transporter signature motif; other site
65393004372	Walker B; other site
65393004373	D-loop; other site
65393004374	H-loop/switch region; other site
65393004375	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393004376	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393004377	putative active site [active]
65393004378	heme pocket [chemical binding]; other site
65393004379	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393004380	putative active site [active]
65393004381	heme pocket [chemical binding]; other site
65393004382	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393004383	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393004384	metal binding site [ion binding]; metal-binding site
65393004385	active site
65393004386	I-site; other site
65393004387	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393004388	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
65393004389	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393004390	FeS/SAM binding site; other site
65393004391	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
65393004392	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
65393004393	substrate binding site [chemical binding]; other site
65393004394	oxyanion hole (OAH) forming residues; other site
65393004395	trimer interface [polypeptide binding]; other site
65393004396	Protein of unknown function (DUF721); Region: DUF721; cl02324
65393004397	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
65393004398	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
65393004399	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
65393004400	G1 box; other site
65393004401	GTP/Mg2+ binding site [chemical binding]; other site
65393004402	Switch I region; other site
65393004403	G2 box; other site
65393004404	Switch II region; other site
65393004405	G3 box; other site
65393004406	G4 box; other site
65393004407	G5 box; other site
65393004408	Domain of unknown function (DUF697); Region: DUF697; pfam05128
65393004409	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393004410	binding surface
65393004411	TPR motif; other site
65393004412	TPR repeat; Region: TPR_11; pfam13414
65393004413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393004414	binding surface
65393004415	TPR motif; other site
65393004416	TPR repeat; Region: TPR_11; pfam13414
65393004417	putative lipid kinase; Reviewed; Region: PRK00861
65393004418	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
65393004419	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
65393004420	dimanganese center [ion binding]; other site
65393004421	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
65393004422	GUN4-like; Region: GUN4; pfam05419
65393004423	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
65393004424	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
65393004425	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
65393004426	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
65393004427	Protein kinase domain; Region: Pkinase; pfam00069
65393004428	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
65393004429	active site
65393004430	ATP binding site [chemical binding]; other site
65393004431	substrate binding site [chemical binding]; other site
65393004432	PBP superfamily domain; Region: PBP_like_2; cl17296
65393004433	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
65393004434	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
65393004435	Surface antigen; Region: Bac_surface_Ag; pfam01103
65393004436	haemagglutination activity domain; Region: Haemagg_act; pfam05860
65393004437	CHAT domain; Region: CHAT; cl17868
65393004438	Domain of unknown function (DUF389); Region: DUF389; pfam04087
65393004439	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
65393004440	CAAX protease self-immunity; Region: Abi; pfam02517
65393004441	glutaminase A; Region: Gln_ase; TIGR03814
65393004442	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
65393004443	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
65393004444	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
65393004445	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393004446	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393004447	ligand binding site [chemical binding]; other site
65393004448	flexible hinge region; other site
65393004449	Circadian oscillating protein COP23; Region: COP23; pfam14218
65393004450	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393004451	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393004452	active site
65393004453	ATP binding site [chemical binding]; other site
65393004454	substrate binding site [chemical binding]; other site
65393004455	activation loop (A-loop); other site
65393004456	Circadian oscillating protein COP23; Region: COP23; pfam14218
65393004457	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393004458	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393004459	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
65393004460	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
65393004461	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
65393004462	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
65393004463	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
65393004464	Peptidase family M23; Region: Peptidase_M23; pfam01551
65393004465	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
65393004466	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65393004467	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
65393004468	N-acetyl-D-glucosamine binding site [chemical binding]; other site
65393004469	catalytic residue [active]
65393004470	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
65393004471	NADH(P)-binding; Region: NAD_binding_10; pfam13460
65393004472	NAD(P) binding site [chemical binding]; other site
65393004473	putative active site [active]
65393004474	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
65393004475	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
65393004476	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
65393004477	active site
65393004478	intersubunit interface [polypeptide binding]; other site
65393004479	catalytic residue [active]
65393004480	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65393004481	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
65393004482	active site
65393004483	metal binding site [ion binding]; metal-binding site
65393004484	CVNH domain; Region: CVNH; pfam08881
65393004485	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393004486	Ligand Binding Site [chemical binding]; other site
65393004487	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
65393004488	active site
65393004489	putative DNA-binding cleft [nucleotide binding]; other site
65393004490	dimer interface [polypeptide binding]; other site
65393004491	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
65393004492	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
65393004493	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
65393004494	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
65393004495	16S/18S rRNA binding site [nucleotide binding]; other site
65393004496	S13e-L30e interaction site [polypeptide binding]; other site
65393004497	25S rRNA binding site [nucleotide binding]; other site
65393004498	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393004499	NADH(P)-binding; Region: NAD_binding_10; pfam13460
65393004500	NAD(P) binding site [chemical binding]; other site
65393004501	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
65393004502	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
65393004503	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393004504	active site
65393004505	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
65393004506	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
65393004507	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
65393004508	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
65393004509	active site
65393004510	dimer interface [polypeptide binding]; other site
65393004511	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65393004512	active site
65393004513	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
65393004514	ATP adenylyltransferase; Region: ATP_transf; pfam09830
65393004515	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004516	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
65393004517	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65393004518	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393004519	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393004520	Probable transposase; Region: OrfB_IS605; pfam01385
65393004521	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393004522	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65393004523	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393004524	hypothetical protein; Provisional; Region: PRK07394
65393004525	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
65393004526	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
65393004527	HEAT repeats; Region: HEAT_2; pfam13646
65393004528	HEAT repeats; Region: HEAT_2; pfam13646
65393004529	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
65393004530	active site
65393004531	SAM binding site [chemical binding]; other site
65393004532	homodimer interface [polypeptide binding]; other site
65393004533	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
65393004534	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
65393004535	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
65393004536	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
65393004537	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393004538	S-adenosylmethionine binding site [chemical binding]; other site
65393004539	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
65393004540	L-aspartate oxidase; Provisional; Region: PRK06175
65393004541	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
65393004542	hydroxyglutarate oxidase; Provisional; Region: PRK11728
65393004543	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
65393004544	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
65393004545	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
65393004546	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393004547	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393004548	Probable transposase; Region: OrfB_IS605; pfam01385
65393004549	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393004550	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
65393004551	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
65393004552	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
65393004553	iron-sulfur cluster [ion binding]; other site
65393004554	[2Fe-2S] cluster binding site [ion binding]; other site
65393004555	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
65393004556	active site residue [active]
65393004557	Predicted transcriptional regulators [Transcription]; Region: COG1695
65393004558	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
65393004559	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
65393004560	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
65393004561	Cysteine-rich domain; Region: CCG; pfam02754
65393004562	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
65393004563	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65393004564	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
65393004565	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
65393004566	Cysteine-rich domain; Region: CCG; pfam02754
65393004567	Cysteine-rich domain; Region: CCG; pfam02754
65393004568	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
65393004569	dimerization interface [polypeptide binding]; other site
65393004570	putative DNA binding site [nucleotide binding]; other site
65393004571	putative Zn2+ binding site [ion binding]; other site
65393004572	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
65393004573	active site residue [active]
65393004574	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
65393004575	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
65393004576	active site residue [active]
65393004577	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
65393004578	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
65393004579	pheophytin binding site; other site
65393004580	chlorophyll binding site; other site
65393004581	quinone binding site; other site
65393004582	Fe binding site [ion binding]; other site
65393004583	WYL domain; Region: WYL; pfam13280
65393004584	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393004585	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
65393004586	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
65393004587	CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712
65393004588	CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174
65393004589	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869
65393004590	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
65393004591	CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159
65393004592	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
65393004593	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
65393004594	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
65393004595	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
65393004596	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
65393004597	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
65393004598	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65393004599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393004600	S-adenosylmethionine binding site [chemical binding]; other site
65393004601	Response regulator receiver domain; Region: Response_reg; pfam00072
65393004602	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393004603	active site
65393004604	phosphorylation site [posttranslational modification]
65393004605	intermolecular recognition site; other site
65393004606	dimerization interface [polypeptide binding]; other site
65393004607	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393004608	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393004609	active site
65393004610	phosphorylation site [posttranslational modification]
65393004611	intermolecular recognition site; other site
65393004612	dimerization interface [polypeptide binding]; other site
65393004613	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393004614	DNA binding site [nucleotide binding]
65393004615	Hpt domain; Region: Hpt; pfam01627
65393004616	putative binding surface; other site
65393004617	active site
65393004618	Response regulator receiver domain; Region: Response_reg; pfam00072
65393004619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393004620	active site
65393004621	phosphorylation site [posttranslational modification]
65393004622	intermolecular recognition site; other site
65393004623	dimerization interface [polypeptide binding]; other site
65393004624	Response regulator receiver domain; Region: Response_reg; pfam00072
65393004625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393004626	active site
65393004627	phosphorylation site [posttranslational modification]
65393004628	intermolecular recognition site; other site
65393004629	dimerization interface [polypeptide binding]; other site
65393004630	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
65393004631	amphipathic channel; other site
65393004632	Asn-Pro-Ala signature motifs; other site
65393004633	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
65393004634	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
65393004635	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
65393004636	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
65393004637	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
65393004638	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
65393004639	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
65393004640	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
65393004641	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
65393004642	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
65393004643	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393004644	binding surface
65393004645	TPR motif; other site
65393004646	TPR repeat; Region: TPR_11; pfam13414
65393004647	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393004648	TPR motif; other site
65393004649	binding surface
65393004650	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393004651	binding surface
65393004652	TPR repeat; Region: TPR_11; pfam13414
65393004653	TPR motif; other site
65393004654	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393004655	TPR repeat; Region: TPR_11; pfam13414
65393004656	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393004657	binding surface
65393004658	TPR motif; other site
65393004659	TPR repeat; Region: TPR_11; pfam13414
65393004660	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65393004661	binding surface
65393004662	TPR motif; other site
65393004663	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393004664	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
65393004665	Walker A motif; other site
65393004666	ATP binding site [chemical binding]; other site
65393004667	Walker B motif; other site
65393004668	arginine finger; other site
65393004669	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
65393004670	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
65393004671	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
65393004672	active site
65393004673	catalytic site [active]
65393004674	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
65393004675	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
65393004676	active site
65393004677	ATP binding site [chemical binding]; other site
65393004678	PBP superfamily domain; Region: PBP_like_2; cl17296
65393004679	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
65393004680	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
65393004681	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
65393004682	phage tail protein domain; Region: tail_TIGR02242
65393004683	Cache domain; Region: Cache_1; pfam02743
65393004684	HAMP domain; Region: HAMP; pfam00672
65393004685	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393004686	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
65393004687	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
65393004688	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
65393004689	Predicted membrane protein [Function unknown]; Region: COG1470
65393004690	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004691	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393004692	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004693	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004694	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65393004695	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004696	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004697	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004698	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004699	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393004700	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
65393004701	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
65393004702	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
65393004703	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
65393004704	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
65393004705	active site
65393004706	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
65393004707	haemagglutination activity domain; Region: Haemagg_act; pfam05860
65393004708	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004709	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393004710	binding surface
65393004711	TPR motif; other site
65393004712	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
65393004714	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
65393004715	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
65393004716	CHASE2 domain; Region: CHASE2; pfam05226
65393004717	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393004718	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393004719	metal binding site [ion binding]; metal-binding site
65393004720	active site
65393004721	I-site; other site
65393004722	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
65393004723	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
65393004724	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
65393004725	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
65393004726	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393004727	NACHT domain; Region: NACHT; pfam05729
65393004728	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393004729	Walker A motif; other site
65393004730	Walker A/P-loop; other site
65393004731	ATP binding site [chemical binding]; other site
65393004732	ATP binding site [chemical binding]; other site
65393004733	Walker B motif; other site
65393004734	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
65393004735	HEAT repeats; Region: HEAT_2; pfam13646
65393004736	HEAT repeats; Region: HEAT_2; pfam13646
65393004737	HEAT repeats; Region: HEAT_2; pfam13646
65393004738	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
65393004739	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
65393004740	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
65393004741	NADP binding site [chemical binding]; other site
65393004742	substrate binding site [chemical binding]; other site
65393004743	active site
65393004744	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
65393004745	excinuclease ABC subunit B; Provisional; Region: PRK05298
65393004746	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393004747	ATP binding site [chemical binding]; other site
65393004748	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65393004749	nucleotide binding region [chemical binding]; other site
65393004750	ATP-binding site [chemical binding]; other site
65393004751	Ultra-violet resistance protein B; Region: UvrB; pfam12344
65393004752	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
65393004753	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
65393004754	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
65393004755	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65393004756	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65393004757	catalytic loop [active]
65393004758	iron binding site [ion binding]; other site
65393004759	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
65393004760	active site
65393004761	catalytic triad [active]
65393004762	oxyanion hole [active]
65393004763	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
65393004764	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65393004765	methionine sulfoxide reductase B; Provisional; Region: PRK00222
65393004766	SelR domain; Region: SelR; pfam01641
65393004767	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
65393004768	elongation factor G; Reviewed; Region: PRK12740
65393004769	G1 box; other site
65393004770	putative GEF interaction site [polypeptide binding]; other site
65393004771	GTP/Mg2+ binding site [chemical binding]; other site
65393004772	Switch I region; other site
65393004773	G2 box; other site
65393004774	G3 box; other site
65393004775	Switch II region; other site
65393004776	G4 box; other site
65393004777	G5 box; other site
65393004778	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
65393004779	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
65393004780	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
65393004781	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393004782	putative active site [active]
65393004783	multifunctional aminopeptidase A; Provisional; Region: PRK00913
65393004784	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
65393004785	interface (dimer of trimers) [polypeptide binding]; other site
65393004786	Substrate-binding/catalytic site; other site
65393004787	Zn-binding sites [ion binding]; other site
65393004788	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
65393004789	Zn2+ binding site [ion binding]; other site
65393004790	Mg2+ binding site [ion binding]; other site
65393004791	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
65393004792	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
65393004793	L-asparaginase II; Region: Asparaginase_II; cl01842
65393004794	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
65393004795	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
65393004796	ring oligomerisation interface [polypeptide binding]; other site
65393004797	ATP/Mg binding site [chemical binding]; other site
65393004798	stacking interactions; other site
65393004799	hinge regions; other site
65393004800	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
65393004801	oligomerisation interface [polypeptide binding]; other site
65393004802	mobile loop; other site
65393004803	roof hairpin; other site
65393004804	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
65393004805	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393004806	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
65393004807	dimerization interface [polypeptide binding]; other site
65393004808	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
65393004809	glutamate racemase; Provisional; Region: PRK00865
65393004810	AMIN domain; Region: AMIN; pfam11741
65393004811	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
65393004812	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
65393004813	active site
65393004814	metal binding site [ion binding]; metal-binding site
65393004815	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
65393004816	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
65393004817	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
65393004818	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
65393004819	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
65393004820	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
65393004821	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
65393004822	hinge; other site
65393004823	active site
65393004824	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004825	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004826	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393004827	binding surface
65393004828	TPR motif; other site
65393004829	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004830	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004831	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393004832	binding surface
65393004833	TPR motif; other site
65393004834	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004835	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004836	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393004837	binding surface
65393004838	TPR motif; other site
65393004839	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004840	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004841	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393004842	binding surface
65393004843	TPR motif; other site
65393004844	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004845	CHAT domain; Region: CHAT; pfam12770
65393004846	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393004847	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393004848	PAS domain; Region: PAS_8; pfam13188
65393004849	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393004850	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393004851	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393004852	putative active site [active]
65393004853	heme pocket [chemical binding]; other site
65393004854	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393004855	putative active site [active]
65393004856	heme pocket [chemical binding]; other site
65393004857	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393004858	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393004859	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393004860	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393004861	metal binding site [ion binding]; metal-binding site
65393004862	active site
65393004863	I-site; other site
65393004864	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393004865	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
65393004866	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
65393004867	dimer interface [polypeptide binding]; other site
65393004868	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
65393004869	active site
65393004870	Fe binding site [ion binding]; other site
65393004871	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65393004872	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393004873	S-adenosylmethionine binding site [chemical binding]; other site
65393004874	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65393004875	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
65393004876	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
65393004877	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
65393004878	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
65393004879	iron-sulfur cluster [ion binding]; other site
65393004880	[2Fe-2S] cluster binding site [ion binding]; other site
65393004881	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393004882	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
65393004883	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
65393004884	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
65393004885	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
65393004886	This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063
65393004887	nickel binding site [ion binding]; other site
65393004888	PIN domain; Region: PIN; pfam01850
65393004889	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
65393004890	TM2 domain; Region: TM2; cl00984
65393004891	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
65393004892	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
65393004893	putative active site [active]
65393004894	adenylation catalytic residue [active]
65393004895	seryl-tRNA synthetase; Provisional; Region: PRK05431
65393004896	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
65393004897	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
65393004898	dimer interface [polypeptide binding]; other site
65393004899	active site
65393004900	motif 1; other site
65393004901	motif 2; other site
65393004902	motif 3; other site
65393004903	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
65393004904	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
65393004905	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
65393004906	metal ion-dependent adhesion site (MIDAS); other site
65393004907	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393004908	putative active site [active]
65393004909	DNA methylase; Region: N6_N4_Mtase; cl17433
65393004910	phosphoenolpyruvate synthase; Validated; Region: PRK06464
65393004911	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
65393004912	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
65393004913	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
65393004914	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
65393004915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393004916	NAD(P) binding site [chemical binding]; other site
65393004917	active site
65393004918	Predicted permeases [General function prediction only]; Region: COG0795
65393004919	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
65393004920	Protein of unknown function, DUF393; Region: DUF393; pfam04134
65393004921	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
65393004922	ArsC family; Region: ArsC; pfam03960
65393004923	putative catalytic residues [active]
65393004924	carotene isomerase; Region: carot_isom; TIGR02730
65393004925	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393004926	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
65393004927	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393004928	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
65393004929	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
65393004930	G1 box; other site
65393004931	putative GEF interaction site [polypeptide binding]; other site
65393004932	GTP/Mg2+ binding site [chemical binding]; other site
65393004933	Switch I region; other site
65393004934	G2 box; other site
65393004935	G3 box; other site
65393004936	Switch II region; other site
65393004937	G4 box; other site
65393004938	G5 box; other site
65393004939	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
65393004940	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
65393004941	Glucose inhibited division protein A; Region: GIDA; pfam01134
65393004942	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
65393004943	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
65393004944	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
65393004945	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
65393004946	substrate binding pocket [chemical binding]; other site
65393004947	membrane-bound complex binding site; other site
65393004948	hinge residues; other site
65393004949	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
65393004950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393004951	dimer interface [polypeptide binding]; other site
65393004952	conserved gate region; other site
65393004953	putative PBP binding loops; other site
65393004954	ABC-ATPase subunit interface; other site
65393004955	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
65393004956	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
65393004957	Walker A/P-loop; other site
65393004958	ATP binding site [chemical binding]; other site
65393004959	Q-loop/lid; other site
65393004960	ABC transporter signature motif; other site
65393004961	Walker B; other site
65393004962	D-loop; other site
65393004963	H-loop/switch region; other site
65393004964	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
65393004965	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
65393004966	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
65393004967	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
65393004968	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
65393004969	NAD binding site [chemical binding]; other site
65393004970	putative substrate binding site 2 [chemical binding]; other site
65393004971	putative substrate binding site 1 [chemical binding]; other site
65393004972	active site
65393004973	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
65393004974	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
65393004975	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
65393004976	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393004977	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393004978	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393004979	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393004980	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393004981	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393004982	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393004983	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393004984	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393004985	dimer interface [polypeptide binding]; other site
65393004986	phosphorylation site [posttranslational modification]
65393004987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393004988	ATP binding site [chemical binding]; other site
65393004989	Mg2+ binding site [ion binding]; other site
65393004990	G-X-G motif; other site
65393004991	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393004992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393004993	active site
65393004994	phosphorylation site [posttranslational modification]
65393004995	intermolecular recognition site; other site
65393004996	dimerization interface [polypeptide binding]; other site
65393004997	AAA domain; Region: AAA_21; pfam13304
65393004998	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393004999	ABC transporter signature motif; other site
65393005000	Walker B; other site
65393005001	D-loop; other site
65393005002	H-loop/switch region; other site
65393005003	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
65393005004	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
65393005005	HIGH motif; other site
65393005006	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
65393005007	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
65393005008	active site
65393005009	KMSKS motif; other site
65393005010	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
65393005011	tRNA binding surface [nucleotide binding]; other site
65393005012	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393005013	AAA domain; Region: AAA_21; pfam13304
65393005014	Walker A/P-loop; other site
65393005015	ATP binding site [chemical binding]; other site
65393005016	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
65393005017	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
65393005018	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
65393005019	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
65393005020	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
65393005021	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
65393005022	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
65393005023	Protein of unknown function (DUF751); Region: DUF751; pfam05421
65393005024	Uncharacterized conserved protein [Function unknown]; Region: COG1359
65393005025	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
65393005026	Peptidase family M50; Region: Peptidase_M50; pfam02163
65393005027	active site
65393005028	putative substrate binding region [chemical binding]; other site
65393005029	FOG: CBS domain [General function prediction only]; Region: COG0517
65393005030	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
65393005031	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
65393005032	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
65393005033	active site
65393005034	acyl-CoA synthetase; Validated; Region: PRK05850
65393005035	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
65393005036	acyl-activating enzyme (AAE) consensus motif; other site
65393005037	active site
65393005038	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
65393005039	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
65393005040	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
65393005041	active site
65393005042	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
65393005043	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
65393005044	KR domain; Region: KR; pfam08659
65393005045	putative NADP binding site [chemical binding]; other site
65393005046	active site
65393005047	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
65393005048	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393005049	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65393005050	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65393005051	Clp protease ATP binding subunit; Region: clpC; CHL00095
65393005052	Clp amino terminal domain; Region: Clp_N; pfam02861
65393005053	Clp amino terminal domain; Region: Clp_N; pfam02861
65393005054	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393005055	Walker A motif; other site
65393005056	ATP binding site [chemical binding]; other site
65393005057	Walker B motif; other site
65393005058	arginine finger; other site
65393005059	UvrB/uvrC motif; Region: UVR; pfam02151
65393005060	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393005061	Walker A motif; other site
65393005062	ATP binding site [chemical binding]; other site
65393005063	Walker B motif; other site
65393005064	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
65393005065	HerA helicase [Replication, recombination, and repair]; Region: COG0433
65393005066	Domain of unknown function DUF87; Region: DUF87; pfam01935
65393005067	Domain of unknown function (DUF4338); Region: DUF4338; pfam14236
65393005068	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393005069	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393005070	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393005071	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
65393005072	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65393005073	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
65393005074	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393005075	Coenzyme A binding pocket [chemical binding]; other site
65393005076	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
65393005077	MoaE interaction surface [polypeptide binding]; other site
65393005078	MoeB interaction surface [polypeptide binding]; other site
65393005079	thiocarboxylated glycine; other site
65393005080	Protein of unknown function (DUF552); Region: DUF552; pfam04472
65393005081	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
65393005082	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
65393005083	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
65393005084	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
65393005085	CHASE2 domain; Region: CHASE2; pfam05226
65393005086	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393005087	metal binding site [ion binding]; metal-binding site
65393005088	active site
65393005089	I-site; other site
65393005090	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393005091	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
65393005092	substrate binding pocket [chemical binding]; other site
65393005093	substrate-Mg2+ binding site; other site
65393005094	aspartate-rich region 1; other site
65393005095	aspartate-rich region 2; other site
65393005096	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
65393005097	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
65393005098	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393005099	dimer interface [polypeptide binding]; other site
65393005100	conserved gate region; other site
65393005101	putative PBP binding loops; other site
65393005102	ABC-ATPase subunit interface; other site
65393005103	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
65393005104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393005105	dimer interface [polypeptide binding]; other site
65393005106	conserved gate region; other site
65393005107	putative PBP binding loops; other site
65393005108	ABC-ATPase subunit interface; other site
65393005109	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
65393005110	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
65393005111	shikimate kinase; Reviewed; Region: aroK; PRK00131
65393005112	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
65393005113	ADP binding site [chemical binding]; other site
65393005114	magnesium binding site [ion binding]; other site
65393005115	putative shikimate binding site; other site
65393005116	Predicted membrane protein [Function unknown]; Region: COG4325
65393005117	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
65393005118	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
65393005119	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
65393005120	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
65393005121	trimer interface [polypeptide binding]; other site
65393005122	active site
65393005123	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
65393005124	catalytic site [active]
65393005125	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
65393005126	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393005127	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65393005128	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
65393005129	active site
65393005130	catalytic tetrad [active]
65393005131	CVNH domain; Region: CVNH; pfam08881
65393005132	CVNH domain; Region: CVNH; pfam08881
65393005133	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
65393005134	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
65393005135	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
65393005136	High-affinity nickel-transport protein; Region: NicO; cl00964
65393005137	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
65393005138	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
65393005139	Ligand binding site; other site
65393005140	Putative Catalytic site; other site
65393005141	DXD motif; other site
65393005142	Predicted membrane protein [Function unknown]; Region: COG2246
65393005143	GtrA-like protein; Region: GtrA; pfam04138
65393005144	Uncharacterized conserved protein [Function unknown]; Region: COG1262
65393005145	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
65393005146	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
65393005147	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65393005148	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
65393005149	Predicted membrane protein [Function unknown]; Region: COG3463
65393005150	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
65393005151	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
65393005152	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
65393005153	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
65393005154	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393005155	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393005156	Protein of unknown function, DUF479; Region: DUF479; cl01203
65393005157	hydrolase, alpha/beta fold family protein; Region: PLN02824
65393005158	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
65393005159	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
65393005160	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
65393005161	Bacterial Ig-like domain; Region: Big_5; pfam13205
65393005162	Anti-sigma-K factor rskA; Region: RskA; pfam10099
65393005163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393005164	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
65393005165	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
65393005166	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
65393005167	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
65393005168	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
65393005169	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
65393005170	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
65393005171	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65393005172	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
65393005173	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
65393005174	Soluble P-type ATPase [General function prediction only]; Region: COG4087
65393005175	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
65393005176	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
65393005177	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
65393005178	putative ADP-binding pocket [chemical binding]; other site
65393005179	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
65393005180	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
65393005181	ABC1 family; Region: ABC1; pfam03109
65393005182	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
65393005183	active site
65393005184	substrate binding site [chemical binding]; other site
65393005185	ATP binding site [chemical binding]; other site
65393005186	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393005187	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
65393005188	protein binding site [polypeptide binding]; other site
65393005189	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
65393005190	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393005191	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
65393005192	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
65393005193	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
65393005194	glycogen synthase; Provisional; Region: glgA; PRK00654
65393005195	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
65393005196	ADP-binding pocket [chemical binding]; other site
65393005197	homodimer interface [polypeptide binding]; other site
65393005198	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
65393005199	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
65393005200	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
65393005201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393005202	Walker A motif; other site
65393005203	ATP binding site [chemical binding]; other site
65393005204	Walker B motif; other site
65393005205	arginine finger; other site
65393005206	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
65393005207	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
65393005208	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393005209	structural tetrad; other site
65393005210	Response regulator receiver domain; Region: Response_reg; pfam00072
65393005211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393005212	active site
65393005213	phosphorylation site [posttranslational modification]
65393005214	intermolecular recognition site; other site
65393005215	dimerization interface [polypeptide binding]; other site
65393005216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393005217	Response regulator receiver domain; Region: Response_reg; pfam00072
65393005218	active site
65393005219	phosphorylation site [posttranslational modification]
65393005220	intermolecular recognition site; other site
65393005221	dimerization interface [polypeptide binding]; other site
65393005222	CheW-like domain; Region: CheW; pfam01584
65393005223	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65393005224	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65393005225	dimer interface [polypeptide binding]; other site
65393005226	putative CheW interface [polypeptide binding]; other site
65393005227	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65393005228	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65393005229	dimer interface [polypeptide binding]; other site
65393005230	putative CheW interface [polypeptide binding]; other site
65393005231	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65393005232	putative binding surface; other site
65393005233	active site
65393005234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393005235	ATP binding site [chemical binding]; other site
65393005236	Mg2+ binding site [ion binding]; other site
65393005237	G-X-G motif; other site
65393005238	Response regulator receiver domain; Region: Response_reg; pfam00072
65393005239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393005240	active site
65393005241	phosphorylation site [posttranslational modification]
65393005242	intermolecular recognition site; other site
65393005243	dimerization interface [polypeptide binding]; other site
65393005244	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
65393005245	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
65393005246	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
65393005247	dimerization interface [polypeptide binding]; other site
65393005248	active site
65393005249	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270
65393005250	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
65393005251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
65393005252	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65393005253	catalytic core [active]
65393005254	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65393005255	catalytic core [active]
65393005256	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
65393005257	NMT1-like family; Region: NMT1_2; pfam13379
65393005258	Phycobilisome protein; Region: Phycobilisome; cl08227
65393005259	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
65393005260	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65393005261	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65393005262	phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418
65393005263	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
65393005264	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
65393005265	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
65393005266	Uncharacterized conserved protein [Function unknown]; Region: COG3391
65393005267	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
65393005268	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
65393005269	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
65393005270	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393005271	dimerization interface [polypeptide binding]; other site
65393005272	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
65393005273	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393005274	dimer interface [polypeptide binding]; other site
65393005275	phosphorylation site [posttranslational modification]
65393005276	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393005277	ATP binding site [chemical binding]; other site
65393005278	Mg2+ binding site [ion binding]; other site
65393005279	G-X-G motif; other site
65393005280	PAS fold; Region: PAS_4; pfam08448
65393005281	GAF domain; Region: GAF_2; pfam13185
65393005282	GAF domain; Region: GAF_3; pfam13492
65393005283	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393005284	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393005285	dimer interface [polypeptide binding]; other site
65393005286	phosphorylation site [posttranslational modification]
65393005287	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393005288	ATP binding site [chemical binding]; other site
65393005289	Mg2+ binding site [ion binding]; other site
65393005290	G-X-G motif; other site
65393005291	Response regulator receiver domain; Region: Response_reg; pfam00072
65393005292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393005293	active site
65393005294	phosphorylation site [posttranslational modification]
65393005295	intermolecular recognition site; other site
65393005296	dimerization interface [polypeptide binding]; other site
65393005297	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393005298	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393005299	putative active site [active]
65393005300	heme pocket [chemical binding]; other site
65393005301	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393005302	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393005303	putative active site [active]
65393005304	heme pocket [chemical binding]; other site
65393005305	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393005306	dimer interface [polypeptide binding]; other site
65393005307	phosphorylation site [posttranslational modification]
65393005308	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393005309	ATP binding site [chemical binding]; other site
65393005310	Mg2+ binding site [ion binding]; other site
65393005311	G-X-G motif; other site
65393005312	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
65393005313	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
65393005314	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
65393005315	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
65393005316	NodB motif; other site
65393005317	active site
65393005318	catalytic site [active]
65393005319	metal binding site [ion binding]; metal-binding site
65393005320	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
65393005321	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393005322	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65393005323	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393005324	DNA binding residues [nucleotide binding]
65393005325	light-harvesting-like protein 3; Provisional; Region: PLN00014
65393005326	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
65393005327	putative metal binding site; other site
65393005328	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393005329	TPR motif; other site
65393005330	binding surface
65393005331	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393005332	binding surface
65393005333	TPR repeat; Region: TPR_11; pfam13414
65393005334	TPR motif; other site
65393005335	TPR repeat; Region: TPR_11; pfam13414
65393005336	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393005337	dimerization interface [polypeptide binding]; other site
65393005338	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
65393005339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393005340	putative active site [active]
65393005341	heme pocket [chemical binding]; other site
65393005342	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393005343	dimer interface [polypeptide binding]; other site
65393005344	phosphorylation site [posttranslational modification]
65393005345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393005346	ATP binding site [chemical binding]; other site
65393005347	Mg2+ binding site [ion binding]; other site
65393005348	G-X-G motif; other site
65393005349	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
65393005350	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
65393005351	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
65393005352	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
65393005353	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
65393005354	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393005355	NAD(P) binding site [chemical binding]; other site
65393005356	active site
65393005357	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
65393005358	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
65393005359	GTP binding site; other site
65393005360	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
65393005361	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65393005362	HSP70 interaction site [polypeptide binding]; other site
65393005363	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393005364	binding surface
65393005365	TPR motif; other site
65393005366	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393005367	binding surface
65393005368	TPR motif; other site
65393005369	Yip1 domain; Region: Yip1; pfam04893
65393005370	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
65393005371	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
65393005372	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
65393005373	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
65393005374	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
65393005375	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
65393005376	active site
65393005377	(T/H)XGH motif; other site
65393005378	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
65393005379	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
65393005380	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
65393005381	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
65393005382	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393005383	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393005384	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
65393005385	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
65393005386	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
65393005387	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
65393005388	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
65393005389	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65393005390	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
65393005391	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393005392	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
65393005393	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393005394	binding surface
65393005395	TPR motif; other site
65393005396	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393005397	binding surface
65393005398	TPR motif; other site
65393005399	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393005400	binding surface
65393005401	TPR motif; other site
65393005402	Circadian oscillating protein COP23; Region: COP23; pfam14218
65393005403	Ion channel; Region: Ion_trans_2; pfam07885
65393005404	Inward rectifier potassium channel; Region: IRK; pfam01007
65393005405	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
65393005406	serpin-like protein; Provisional; Region: PHA02660
65393005407	reactive center loop; other site
65393005408	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
65393005409	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
65393005410	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
65393005411	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
65393005412	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
65393005413	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
65393005414	ATP-NAD kinase; Region: NAD_kinase; pfam01513
65393005415	Ycf39; Provisional; Region: ycf39; CHL00194
65393005416	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
65393005417	NAD(P) binding site [chemical binding]; other site
65393005418	putative active site [active]
65393005419	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65393005420	putative binding surface; other site
65393005421	active site
65393005422	arogenate dehydrogenase; Reviewed; Region: PRK07417
65393005423	prephenate dehydrogenase; Validated; Region: PRK08507
65393005424	Ion transport protein; Region: Ion_trans; pfam00520
65393005425	Ion channel; Region: Ion_trans_2; pfam07885
65393005426	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393005427	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393005428	active site
65393005429	phosphorylation site [posttranslational modification]
65393005430	intermolecular recognition site; other site
65393005431	dimerization interface [polypeptide binding]; other site
65393005432	PAS domain S-box; Region: sensory_box; TIGR00229
65393005433	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393005434	putative active site [active]
65393005435	heme pocket [chemical binding]; other site
65393005436	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393005437	PAS fold; Region: PAS_3; pfam08447
65393005438	putative active site [active]
65393005439	heme pocket [chemical binding]; other site
65393005440	PAS domain S-box; Region: sensory_box; TIGR00229
65393005441	PAS domain; Region: PAS; smart00091
65393005442	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393005443	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393005444	putative active site [active]
65393005445	heme pocket [chemical binding]; other site
65393005446	PAS domain S-box; Region: sensory_box; TIGR00229
65393005447	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393005448	putative active site [active]
65393005449	heme pocket [chemical binding]; other site
65393005450	PAS fold; Region: PAS_4; pfam08448
65393005451	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393005452	putative active site [active]
65393005453	heme pocket [chemical binding]; other site
65393005454	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393005455	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393005456	dimer interface [polypeptide binding]; other site
65393005457	phosphorylation site [posttranslational modification]
65393005458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393005459	ATP binding site [chemical binding]; other site
65393005460	Mg2+ binding site [ion binding]; other site
65393005461	G-X-G motif; other site
65393005462	Response regulator receiver domain; Region: Response_reg; pfam00072
65393005463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393005464	active site
65393005465	phosphorylation site [posttranslational modification]
65393005466	intermolecular recognition site; other site
65393005467	dimerization interface [polypeptide binding]; other site
65393005468	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393005469	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393005470	metal binding site [ion binding]; metal-binding site
65393005471	active site
65393005472	I-site; other site
65393005473	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393005474	NifU-like domain; Region: NifU; pfam01106
65393005475	H+ Antiporter protein; Region: 2A0121; TIGR00900
65393005476	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393005477	putative substrate translocation pore; other site
65393005478	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
65393005479	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65393005480	Predicted ATPase [General function prediction only]; Region: COG4637
65393005481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393005482	Walker A/P-loop; other site
65393005483	ATP binding site [chemical binding]; other site
65393005484	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393005485	ABC transporter signature motif; other site
65393005486	Walker B; other site
65393005487	D-loop; other site
65393005488	H-loop/switch region; other site
65393005489	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
65393005490	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393005491	putative active site [active]
65393005492	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
65393005493	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
65393005494	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
65393005495	Predicted ATPase [General function prediction only]; Region: COG4637
65393005496	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393005497	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393005498	Walker A/P-loop; other site
65393005499	Walker A/P-loop; other site
65393005500	ATP binding site [chemical binding]; other site
65393005501	ATP binding site [chemical binding]; other site
65393005502	CTP synthetase; Validated; Region: pyrG; PRK05380
65393005503	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
65393005504	Catalytic site [active]
65393005505	active site
65393005506	UTP binding site [chemical binding]; other site
65393005507	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
65393005508	active site
65393005509	putative oxyanion hole; other site
65393005510	catalytic triad [active]
65393005511	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
65393005512	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393005513	Coenzyme A binding pocket [chemical binding]; other site
65393005514	HEAT repeats; Region: HEAT_2; pfam13646
65393005515	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
65393005516	HEAT repeats; Region: HEAT_2; pfam13646
65393005517	aromatic acid decarboxylase; Validated; Region: PRK05920
65393005518	Flavoprotein; Region: Flavoprotein; pfam02441
65393005519	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
65393005520	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
65393005521	SmpB-tmRNA interface; other site
65393005522	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
65393005523	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
65393005524	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
65393005525	PBP superfamily domain; Region: PBP_like_2; cl17296
65393005526	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
65393005527	ketol-acid reductoisomerase; Provisional; Region: PRK05479
65393005528	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
65393005529	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
65393005530	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
65393005531	C-terminal peptidase (prc); Region: prc; TIGR00225
65393005532	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
65393005533	protein binding site [polypeptide binding]; other site
65393005534	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
65393005535	Catalytic dyad [active]
65393005536	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
65393005537	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393005538	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65393005539	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393005540	DNA binding residues [nucleotide binding]
65393005541	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
65393005542	light-harvesting-like protein 3; Provisional; Region: PLN00014
65393005543	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
65393005544	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
65393005545	DNA binding residues [nucleotide binding]
65393005546	dimer interface [polypeptide binding]; other site
65393005547	metal binding site [ion binding]; metal-binding site
65393005548	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
65393005549	FOG: CBS domain [General function prediction only]; Region: COG0517
65393005550	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
65393005551	CP12 domain; Region: CP12; pfam02672
65393005552	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393005553	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393005554	metal binding site [ion binding]; metal-binding site
65393005555	active site
65393005556	I-site; other site
65393005557	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
65393005558	Probable transposase; Region: OrfB_IS605; pfam01385
65393005559	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393005560	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
65393005561	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
65393005562	active site
65393005563	catalytic residues [active]
65393005564	metal binding site [ion binding]; metal-binding site
65393005565	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
65393005566	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
65393005567	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393005568	S-adenosylmethionine binding site [chemical binding]; other site
65393005569	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393005570	binding surface
65393005571	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393005572	TPR motif; other site
65393005573	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
65393005574	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393005575	dimerization interface [polypeptide binding]; other site
65393005576	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65393005577	dimer interface [polypeptide binding]; other site
65393005578	putative CheW interface [polypeptide binding]; other site
65393005579	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
65393005580	Na binding site [ion binding]; other site
65393005581	hypothetical protein; Reviewed; Region: PRK00024
65393005582	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
65393005583	MPN+ (JAMM) motif; other site
65393005584	Zinc-binding site [ion binding]; other site
65393005585	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393005586	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
65393005587	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
65393005588	anti sigma factor interaction site; other site
65393005589	regulatory phosphorylation site [posttranslational modification]; other site
65393005590	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
65393005591	Bacterial sugar transferase; Region: Bac_transf; pfam02397
65393005592	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
65393005593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
65393005594	Helix-turn-helix domain; Region: HTH_28; pfam13518
65393005595	Winged helix-turn helix; Region: HTH_29; pfam13551
65393005596	Homeodomain-like domain; Region: HTH_32; pfam13565
65393005597	Integrase core domain; Region: rve; pfam00665
65393005598	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
65393005599	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
65393005600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393005601	S-adenosylmethionine binding site [chemical binding]; other site
65393005602	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
65393005603	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
65393005604	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
65393005605	HsdM N-terminal domain; Region: HsdM_N; pfam12161
65393005606	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
65393005607	Methyltransferase domain; Region: Methyltransf_26; pfam13659
65393005608	nucleotide binding region [chemical binding]; other site
65393005609	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
65393005610	ATP-binding site [chemical binding]; other site
65393005611	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
65393005612	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
65393005613	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
65393005614	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
65393005615	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
65393005616	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
65393005617	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
65393005618	Peptidase family M23; Region: Peptidase_M23; pfam01551
65393005619	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
65393005620	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
65393005621	amidohydrolase; Region: amidohydrolases; TIGR01891
65393005622	metal binding site [ion binding]; metal-binding site
65393005623	dimer interface [polypeptide binding]; other site
65393005624	DevC protein; Region: devC; TIGR01185
65393005625	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
65393005626	FtsX-like permease family; Region: FtsX; pfam02687
65393005627	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
65393005628	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65393005629	HlyD family secretion protein; Region: HlyD_3; pfam13437
65393005630	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65393005631	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65393005632	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65393005633	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
65393005634	active site
65393005635	catalytic tetrad [active]
65393005636	Uncharacterized protein involved in cysteine biosynthesis [Amino acid transport and metabolism]; Region: CysZ; COG2981
65393005637	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
65393005638	NADPH bind site [chemical binding]; other site
65393005639	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
65393005640	putative FMN binding site [chemical binding]; other site
65393005641	NADPH bind site [chemical binding]; other site
65393005642	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
65393005643	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
65393005644	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
65393005645	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65393005646	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65393005647	catalytic loop [active]
65393005648	iron binding site [ion binding]; other site
65393005649	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
65393005650	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
65393005651	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
65393005652	ATP binding site [chemical binding]; other site
65393005653	substrate interface [chemical binding]; other site
65393005654	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102
65393005655	Rop-like; Region: Rop-like; pfam05082
65393005656	Protein of unknown function, DUF269; Region: DUF269; pfam03270
65393005657	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
65393005658	Protein of unknown function, DUF269; Region: DUF269; cl03973
65393005659	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
65393005660	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
65393005661	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
65393005662	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
65393005663	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
65393005664	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
65393005665	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
65393005666	MoFe protein beta/alpha subunit interactions; other site
65393005667	Beta subunit P cluster binding residues; other site
65393005668	MoFe protein beta subunit/Fe protein contacts; other site
65393005669	MoFe protein dimer/ dimer interactions; other site
65393005670	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
65393005671	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
65393005672	MoFe protein alpha/beta subunit interactions; other site
65393005673	Alpha subunit P cluster binding residues; other site
65393005674	FeMoco binding residues [chemical binding]; other site
65393005675	MoFe protein alpha subunit/Fe protein contacts; other site
65393005676	MoFe protein dimer/ dimer interactions; other site
65393005677	nitrogenase reductase; Reviewed; Region: PRK13236
65393005678	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
65393005679	Nucleotide-binding sites [chemical binding]; other site
65393005680	Walker A motif; other site
65393005681	Switch I region of nucleotide binding site; other site
65393005682	Fe4S4 binding sites [ion binding]; other site
65393005683	Switch II region of nucleotide binding site; other site
65393005684	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
65393005685	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
65393005686	trimerization site [polypeptide binding]; other site
65393005687	active site
65393005688	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
65393005689	NifU-like domain; Region: NifU; pfam01106
65393005690	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
65393005691	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
65393005692	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65393005693	catalytic residue [active]
65393005694	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
65393005695	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
65393005696	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393005697	FeS/SAM binding site; other site
65393005698	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
65393005699	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
65393005700	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
65393005701	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
65393005702	trimer interface [polypeptide binding]; other site
65393005703	active site
65393005704	substrate binding site [chemical binding]; other site
65393005705	CoA binding site [chemical binding]; other site
65393005706	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
65393005707	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
65393005708	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
65393005709	active site
65393005710	catalytic residues [active]
65393005711	metal binding site [ion binding]; metal-binding site
65393005712	NifZ domain; Region: NifZ; pfam04319
65393005713	NifT/FixU protein; Region: NifT; pfam06988
65393005714	FOG: CBS domain [General function prediction only]; Region: COG0517
65393005715	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
65393005716	CP12 domain; Region: CP12; smart01093
65393005717	4Fe-4S binding domain; Region: Fer4; pfam00037
65393005718	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
65393005719	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65393005720	non-specific DNA binding site [nucleotide binding]; other site
65393005721	salt bridge; other site
65393005722	sequence-specific DNA binding site [nucleotide binding]; other site
65393005723	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
65393005724	EamA-like transporter family; Region: EamA; cl17759
65393005725	EamA-like transporter family; Region: EamA; cl17759
65393005726	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
65393005727	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
65393005728	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
65393005729	active site
65393005730	phosphate binding residues; other site
65393005731	catalytic residues [active]
65393005732	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
65393005733	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393005734	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393005735	Probable transposase; Region: OrfB_IS605; pfam01385
65393005736	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393005737	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
65393005738	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65393005739	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393005740	homodimer interface [polypeptide binding]; other site
65393005741	catalytic residue [active]
65393005742	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
65393005743	catalytic residues [active]
65393005744	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
65393005745	DevC protein; Region: devC; TIGR01185
65393005746	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
65393005747	FtsX-like permease family; Region: FtsX; pfam02687
65393005748	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
65393005749	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
65393005750	Walker A/P-loop; other site
65393005751	ATP binding site [chemical binding]; other site
65393005752	Q-loop/lid; other site
65393005753	ABC transporter signature motif; other site
65393005754	Walker B; other site
65393005755	D-loop; other site
65393005756	H-loop/switch region; other site
65393005757	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393005758	S-adenosylmethionine binding site [chemical binding]; other site
65393005759	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
65393005760	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
65393005761	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
65393005762	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
65393005763	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
65393005764	Ankyrin repeat; Region: Ank; pfam00023
65393005765	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
65393005766	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
65393005767	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
65393005768	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
65393005769	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
65393005770	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
65393005771	amidase; Provisional; Region: PRK09201
65393005772	Amidase; Region: Amidase; cl11426
65393005773	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
65393005774	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65393005775	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
65393005776	Hexamer interface [polypeptide binding]; other site
65393005777	Hexagonal pore residue; other site
65393005778	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65393005779	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
65393005780	Hexamer interface [polypeptide binding]; other site
65393005781	Hexagonal pore residue; other site
65393005782	gamma-glutamyl kinase; Provisional; Region: PRK05429
65393005783	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
65393005784	nucleotide binding site [chemical binding]; other site
65393005785	homotetrameric interface [polypeptide binding]; other site
65393005786	putative phosphate binding site [ion binding]; other site
65393005787	putative allosteric binding site; other site
65393005788	PUA domain; Region: PUA; pfam01472
65393005789	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
65393005790	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393005791	active site
65393005792	motif I; other site
65393005793	motif II; other site
65393005794	ferrochelatase; Reviewed; Region: hemH; PRK00035
65393005795	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
65393005796	active site
65393005797	C-terminal domain interface [polypeptide binding]; other site
65393005798	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
65393005799	active site
65393005800	N-terminal domain interface [polypeptide binding]; other site
65393005801	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504
65393005802	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393005803	putative active site [active]
65393005804	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
65393005805	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393005806	putative active site [active]
65393005807	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
65393005808	active site
65393005809	catalytic triad [active]
65393005810	oxyanion hole [active]
65393005811	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
65393005812	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
65393005813	malate dehydrogenase; Reviewed; Region: PRK06223
65393005814	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
65393005815	NAD(P) binding site [chemical binding]; other site
65393005816	dimer interface [polypeptide binding]; other site
65393005817	tetramer (dimer of dimers) interface [polypeptide binding]; other site
65393005818	substrate binding site [chemical binding]; other site
65393005819	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
65393005820	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393005821	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
65393005822	hydroxyglutarate oxidase; Provisional; Region: PRK11728
65393005823	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
65393005824	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
65393005825	putative active site [active]
65393005826	putative metal binding site [ion binding]; other site
65393005827	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
65393005828	MPN+ (JAMM) motif; other site
65393005829	Zinc-binding site [ion binding]; other site
65393005830	cobalt transport protein CbiM; Validated; Region: PRK06265
65393005831	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
65393005832	PDGLE domain; Region: PDGLE; pfam13190
65393005833	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
65393005834	Predicted membrane protein [Function unknown]; Region: COG1971
65393005835	Domain of unknown function DUF; Region: DUF204; pfam02659
65393005836	Domain of unknown function DUF; Region: DUF204; pfam02659
65393005837	Response regulator receiver domain; Region: Response_reg; pfam00072
65393005838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393005839	active site
65393005840	phosphorylation site [posttranslational modification]
65393005841	intermolecular recognition site; other site
65393005842	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393005843	dimerization interface [polypeptide binding]; other site
65393005844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
65393005845	dimer interface [polypeptide binding]; other site
65393005846	phosphorylation site [posttranslational modification]
65393005847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393005848	ATP binding site [chemical binding]; other site
65393005849	Mg2+ binding site [ion binding]; other site
65393005850	G-X-G motif; other site
65393005851	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
65393005852	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
65393005853	Pheophorbide a oxygenase; Region: PaO; pfam08417
65393005854	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393005855	Radical SAM superfamily; Region: Radical_SAM; pfam04055
65393005856	FeS/SAM binding site; other site
65393005857	Putative restriction endonuclease; Region: Uma2; pfam05685
65393005858	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65393005859	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
65393005860	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
65393005861	active site
65393005862	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393005863	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393005864	Probable transposase; Region: OrfB_IS605; pfam01385
65393005865	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393005866	allophycocyanin, beta subunit; Region: apcB; TIGR01337
65393005867	glutamine synthetase, type I; Region: GlnA; TIGR00653
65393005868	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
65393005869	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
65393005870	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65393005871	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393005872	S-adenosylmethionine binding site [chemical binding]; other site
65393005873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
65393005874	Protein of unknown function (DUF433); Region: DUF433; cl01030
65393005875	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393005876	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393005877	Probable transposase; Region: OrfB_IS605; pfam01385
65393005878	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393005879	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
65393005880	phosphoglyceromutase; Provisional; Region: PRK05434
65393005881	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
65393005882	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
65393005883	active site
65393005884	Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131
65393005885	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
65393005886	NAD binding site [chemical binding]; other site
65393005887	catalytic residues [active]
65393005888	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
65393005889	CARDB; Region: CARDB; pfam07705
65393005890	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
65393005891	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
65393005892	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
65393005893	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
65393005894	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
65393005895	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
65393005896	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
65393005897	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
65393005898	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
65393005899	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
65393005900	FAD binding domain; Region: FAD_binding_4; pfam01565
65393005901	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
65393005902	hypothetical protein; Validated; Region: PRK00153
65393005903	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393005904	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393005905	Probable transposase; Region: OrfB_IS605; pfam01385
65393005906	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65393005907	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393005908	S-adenosylmethionine binding site [chemical binding]; other site
65393005909	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
65393005910	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393005911	FeS/SAM binding site; other site
65393005912	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
65393005913	Uncharacterized conserved protein [Function unknown]; Region: COG0398
65393005914	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
65393005915	Uncharacterized conserved protein [Function unknown]; Region: COG0398
65393005916	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
65393005917	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
65393005918	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
65393005919	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
65393005920	dimer interface [polypeptide binding]; other site
65393005921	putative functional site; other site
65393005922	putative MPT binding site; other site
65393005923	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393005924	PAS fold; Region: PAS_4; pfam08448
65393005925	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393005926	putative active site [active]
65393005927	heme pocket [chemical binding]; other site
65393005928	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
65393005929	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393005930	putative active site [active]
65393005931	heme pocket [chemical binding]; other site
65393005932	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393005933	dimer interface [polypeptide binding]; other site
65393005934	phosphorylation site [posttranslational modification]
65393005935	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393005936	ATP binding site [chemical binding]; other site
65393005937	Mg2+ binding site [ion binding]; other site
65393005938	G-X-G motif; other site
65393005939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393005940	Response regulator receiver domain; Region: Response_reg; pfam00072
65393005941	active site
65393005942	phosphorylation site [posttranslational modification]
65393005943	intermolecular recognition site; other site
65393005944	dimerization interface [polypeptide binding]; other site
65393005945	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65393005946	HSP70 interaction site [polypeptide binding]; other site
65393005947	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
65393005948	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
65393005949	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
65393005950	superoxide dismutase; Provisional; Region: PRK10925
65393005951	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
65393005952	Predicted transcriptional regulators [Transcription]; Region: COG1725
65393005953	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
65393005954	DNA-binding site [nucleotide binding]; DNA binding site
65393005955	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
65393005956	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393005957	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
65393005958	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
65393005959	active site
65393005960	catalytic residues [active]
65393005961	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393005962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393005963	active site
65393005964	phosphorylation site [posttranslational modification]
65393005965	intermolecular recognition site; other site
65393005966	dimerization interface [polypeptide binding]; other site
65393005967	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393005968	DNA binding site [nucleotide binding]
65393005969	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
65393005970	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
65393005971	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
65393005972	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
65393005973	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
65393005974	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
65393005975	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
65393005976	metal binding site 2 [ion binding]; metal-binding site
65393005977	putative DNA binding helix; other site
65393005978	metal binding site 1 [ion binding]; metal-binding site
65393005979	dimer interface [polypeptide binding]; other site
65393005980	structural Zn2+ binding site [ion binding]; other site
65393005981	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
65393005982	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
65393005983	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
65393005984	putative active site [active]
65393005985	catalytic triad [active]
65393005986	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
65393005987	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
65393005988	Qi binding site; other site
65393005989	intrachain domain interface; other site
65393005990	interchain domain interface [polypeptide binding]; other site
65393005991	heme bH binding site [chemical binding]; other site
65393005992	heme bL binding site [chemical binding]; other site
65393005993	Qo binding site; other site
65393005994	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
65393005995	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
65393005996	interchain domain interface [polypeptide binding]; other site
65393005997	intrachain domain interface; other site
65393005998	Qi binding site; other site
65393005999	Qo binding site; other site
65393006000	carotene isomerase; Region: carot_isom; TIGR02730
65393006001	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393006002	GAF domain; Region: GAF; pfam01590
65393006003	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393006004	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393006005	dimer interface [polypeptide binding]; other site
65393006006	phosphorylation site [posttranslational modification]
65393006007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393006008	ATP binding site [chemical binding]; other site
65393006009	Mg2+ binding site [ion binding]; other site
65393006010	G-X-G motif; other site
65393006011	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
65393006012	ABC1 family; Region: ABC1; cl17513
65393006013	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65393006014	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
65393006015	cofactor binding site; other site
65393006016	DNA binding site [nucleotide binding]
65393006017	substrate interaction site [chemical binding]; other site
65393006018	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
65393006019	dimer interface [polypeptide binding]; other site
65393006020	catalytic triad [active]
65393006021	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
65393006022	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
65393006023	Multicopper oxidase; Region: Cu-oxidase; pfam00394
65393006024	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
65393006025	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
65393006026	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65393006027	catalytic residue [active]
65393006028	TPR repeat; Region: TPR_11; pfam13414
65393006029	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393006030	binding surface
65393006031	TPR motif; other site
65393006032	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393006033	binding surface
65393006034	TPR repeat; Region: TPR_11; pfam13414
65393006035	TPR motif; other site
65393006036	TPR repeat; Region: TPR_11; pfam13414
65393006037	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
65393006038	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393006039	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65393006040	Response regulator receiver domain; Region: Response_reg; pfam00072
65393006041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393006042	active site
65393006043	phosphorylation site [posttranslational modification]
65393006044	intermolecular recognition site; other site
65393006045	dimerization interface [polypeptide binding]; other site
65393006046	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393006047	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393006048	metal binding site [ion binding]; metal-binding site
65393006049	active site
65393006050	I-site; other site
65393006051	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
65393006052	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
65393006053	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
65393006054	Walker A motif; other site
65393006055	ATP binding site [chemical binding]; other site
65393006056	Walker B motif; other site
65393006057	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
65393006058	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
65393006059	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
65393006060	active site
65393006061	catalytic site [active]
65393006062	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393006063	putative active site [active]
65393006064	heme pocket [chemical binding]; other site
65393006065	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393006066	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393006067	dimer interface [polypeptide binding]; other site
65393006068	phosphorylation site [posttranslational modification]
65393006069	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393006070	ATP binding site [chemical binding]; other site
65393006071	Mg2+ binding site [ion binding]; other site
65393006072	G-X-G motif; other site
65393006073	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393006074	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393006075	active site
65393006076	phosphorylation site [posttranslational modification]
65393006077	intermolecular recognition site; other site
65393006078	dimerization interface [polypeptide binding]; other site
65393006079	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
65393006080	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
65393006081	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
65393006082	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
65393006083	arogenate dehydrogenase; Region: PLN02256
65393006084	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
65393006085	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
65393006086	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
65393006087	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
65393006088	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
65393006089	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
65393006090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393006091	catalytic residue [active]
65393006092	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
65393006093	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
65393006094	substrate binding site [chemical binding]; other site
65393006095	active site
65393006096	catalytic residues [active]
65393006097	heterodimer interface [polypeptide binding]; other site
65393006098	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
65393006099	active site
65393006100	ribulose/triose binding site [chemical binding]; other site
65393006101	phosphate binding site [ion binding]; other site
65393006102	substrate (anthranilate) binding pocket [chemical binding]; other site
65393006103	product (indole) binding pocket [chemical binding]; other site
65393006104	anthranilate synthase; Provisional; Region: PRK13566
65393006105	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
65393006106	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
65393006107	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
65393006108	glutamine binding [chemical binding]; other site
65393006109	catalytic triad [active]
65393006110	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
65393006111	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
65393006112	PYR/PP interface [polypeptide binding]; other site
65393006113	dimer interface [polypeptide binding]; other site
65393006114	TPP binding site [chemical binding]; other site
65393006115	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
65393006116	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
65393006117	TPP-binding site [chemical binding]; other site
65393006118	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
65393006119	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
65393006120	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
65393006121	NAD binding site [chemical binding]; other site
65393006122	Phe binding site; other site
65393006123	Uncharacterized conserved protein [Function unknown]; Region: COG3391
65393006124	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
65393006125	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
65393006126	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
65393006127	active site
65393006128	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
65393006129	UbiA prenyltransferase family; Region: UbiA; pfam01040
65393006130	Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198
65393006131	active site
65393006132	metal binding site [ion binding]; metal-binding site
65393006133	Uncharacterized conserved protein [Function unknown]; Region: COG3379
65393006134	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
65393006135	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
65393006136	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
65393006137	putative catalytic site [active]
65393006138	putative metal binding site [ion binding]; other site
65393006139	putative phosphate binding site [ion binding]; other site
65393006140	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
65393006141	protein I interface; other site
65393006142	D2 interface; other site
65393006143	protein T interface; other site
65393006144	chlorophyll binding site; other site
65393006145	beta carotene binding site; other site
65393006146	pheophytin binding site; other site
65393006147	manganese-stabilizing polypeptide interface; other site
65393006148	CP43 interface; other site
65393006149	protein L interface; other site
65393006150	oxygen evolving complex binding site; other site
65393006151	bromide binding site; other site
65393006152	quinone binding site; other site
65393006153	Fe binding site [ion binding]; other site
65393006154	core light harvesting interface; other site
65393006155	cytochrome b559 alpha subunit interface; other site
65393006156	cytochrome c-550 interface; other site
65393006157	protein J interface; other site
65393006158	DNA topoisomerase 2; Provisional; Region: PLN03128
65393006159	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
65393006160	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
65393006161	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65393006162	catalytic residue [active]
65393006163	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
65393006164	Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622
65393006165	Protein of unknown function (DUF2393); Region: DUF2393; pfam09624
65393006166	TIGR02588 family protein; Region: TIGR02588
65393006167	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
65393006168	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
65393006169	oligomer interface [polypeptide binding]; other site
65393006170	active site residues [active]
65393006171	Clp protease; Region: CLP_protease; pfam00574
65393006172	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
65393006173	oligomer interface [polypeptide binding]; other site
65393006174	active site residues [active]
65393006175	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393006176	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393006177	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393006178	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393006179	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393006180	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
65393006181	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
65393006182	active site
65393006183	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
65393006184	PIN domain; Region: PIN_3; pfam13470
65393006185	AAA ATPase domain; Region: AAA_16; pfam13191
65393006186	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09688
65393006187	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
65393006188	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
65393006189	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl11892
65393006190	CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cl11893
65393006191	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782
65393006192	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393006193	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
65393006194	Walker A motif; other site
65393006195	ATP binding site [chemical binding]; other site
65393006196	Walker B motif; other site
65393006197	arginine finger; other site
65393006198	PIN domain; Region: PIN_3; cl17397
65393006199	TniQ; Region: TniQ; pfam06527
65393006200	AAA domain; Region: AAA_22; pfam13401
65393006201	Integrase core domain; Region: rve; pfam00665
65393006202	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
65393006203	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
65393006204	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
65393006205	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
65393006206	glutaminase active site [active]
65393006207	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
65393006208	dimer interface [polypeptide binding]; other site
65393006209	active site
65393006210	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
65393006211	dimer interface [polypeptide binding]; other site
65393006212	active site
65393006213	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
65393006214	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65393006215	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393006216	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393006217	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393006218	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393006219	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393006220	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
65393006221	glucokinase; Provisional; Region: glk; PRK00292
65393006222	glucokinase, proteobacterial type; Region: glk; TIGR00749
65393006223	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393006224	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393006225	TPR motif; other site
65393006226	binding surface
65393006227	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393006228	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
65393006229	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65393006230	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
65393006231	active site
65393006232	metal binding site [ion binding]; metal-binding site
65393006233	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
65393006234	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
65393006235	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
65393006236	trimer interface [polypeptide binding]; other site
65393006237	putative metal binding site [ion binding]; other site
65393006238	Photosystem II protein Y (PsbY); Region: PsbY; pfam06298
65393006239	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393006240	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
65393006241	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
65393006242	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
65393006243	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
65393006244	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
65393006245	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
65393006246	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
65393006247	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
65393006248	C-terminal domain interface [polypeptide binding]; other site
65393006249	GSH binding site (G-site) [chemical binding]; other site
65393006250	dimer interface [polypeptide binding]; other site
65393006251	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
65393006252	N-terminal domain interface [polypeptide binding]; other site
65393006253	dimer interface [polypeptide binding]; other site
65393006254	substrate binding pocket (H-site) [chemical binding]; other site
65393006255	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
65393006256	Response regulator receiver domain; Region: Response_reg; pfam00072
65393006257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393006258	active site
65393006259	phosphorylation site [posttranslational modification]
65393006260	intermolecular recognition site; other site
65393006261	dimerization interface [polypeptide binding]; other site
65393006262	PAS domain S-box; Region: sensory_box; TIGR00229
65393006263	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393006264	putative active site [active]
65393006265	heme pocket [chemical binding]; other site
65393006266	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393006267	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393006268	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393006269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393006270	active site
65393006271	phosphorylation site [posttranslational modification]
65393006272	intermolecular recognition site; other site
65393006273	dimerization interface [polypeptide binding]; other site
65393006274	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
65393006275	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393006276	Phytochrome region; Region: PHY; pfam00360
65393006277	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393006278	dimer interface [polypeptide binding]; other site
65393006279	phosphorylation site [posttranslational modification]
65393006280	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393006281	ATP binding site [chemical binding]; other site
65393006282	Mg2+ binding site [ion binding]; other site
65393006283	G-X-G motif; other site
65393006284	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65393006285	catalytic core [active]
65393006286	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65393006287	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
65393006288	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
65393006289	domain interfaces; other site
65393006290	active site
65393006291	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
65393006292	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
65393006293	Tetramer interface [polypeptide binding]; other site
65393006294	active site
65393006295	FMN-binding site [chemical binding]; other site
65393006296	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
65393006297	translation initiation factor IF-2; Region: IF-2; TIGR00487
65393006298	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
65393006299	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
65393006300	G1 box; other site
65393006301	putative GEF interaction site [polypeptide binding]; other site
65393006302	GTP/Mg2+ binding site [chemical binding]; other site
65393006303	Switch I region; other site
65393006304	G2 box; other site
65393006305	G3 box; other site
65393006306	Switch II region; other site
65393006307	G4 box; other site
65393006308	G5 box; other site
65393006309	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
65393006310	Translation-initiation factor 2; Region: IF-2; pfam11987
65393006311	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
65393006312	Protein of unknown function (DUF448); Region: DUF448; pfam04296
65393006313	putative RNA binding cleft [nucleotide binding]; other site
65393006314	NusA N-terminal domain; Region: NusA_N; pfam08529
65393006315	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
65393006316	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
65393006317	RNA binding site [nucleotide binding]; other site
65393006318	homodimer interface [polypeptide binding]; other site
65393006319	NusA-like KH domain; Region: KH_5; pfam13184
65393006320	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
65393006321	G-X-X-G motif; other site
65393006322	ribosome maturation protein RimP; Reviewed; Region: PRK00092
65393006323	Sm and related proteins; Region: Sm_like; cl00259
65393006324	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
65393006325	putative oligomer interface [polypeptide binding]; other site
65393006326	putative RNA binding site [nucleotide binding]; other site
65393006327	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
65393006328	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
65393006329	quinone interaction residues [chemical binding]; other site
65393006330	active site
65393006331	catalytic residues [active]
65393006332	FMN binding site [chemical binding]; other site
65393006333	substrate binding site [chemical binding]; other site
65393006334	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
65393006335	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
65393006336	putative di-iron ligands [ion binding]; other site
65393006337	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
65393006338	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393006339	putative active site [active]
65393006340	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
65393006341	Uncharacterized conserved protein [Function unknown]; Region: COG4938
65393006342	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393006343	Walker B; other site
65393006344	D-loop; other site
65393006345	H-loop/switch region; other site
65393006346	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
65393006347	Protein of unknown function DUF262; Region: DUF262; pfam03235
65393006348	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
65393006349	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
65393006350	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
65393006351	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
65393006352	P-loop; other site
65393006353	Peptidase family M48; Region: Peptidase_M48; pfam01435
65393006354	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
65393006355	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
65393006356	putative active site [active]
65393006357	putative dimer interface [polypeptide binding]; other site
65393006358	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
65393006359	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
65393006360	Domain of unknown function (DUF1817); Region: DUF1817; pfam08847
65393006361	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
65393006362	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
65393006363	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
65393006364	Predicted membrane protein [Function unknown]; Region: COG2259
65393006365	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
65393006366	DHH family; Region: DHH; pfam01368
65393006367	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65393006368	FOG: CBS domain [General function prediction only]; Region: COG0517
65393006369	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
65393006370	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
65393006371	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
65393006372	active site
65393006373	NTP binding site [chemical binding]; other site
65393006374	metal binding triad [ion binding]; metal-binding site
65393006375	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
65393006376	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
65393006377	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
65393006378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
65393006379	MORN repeat; Region: MORN; cl14787
65393006380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
65393006381	MORN repeat; Region: MORN; cl14787
65393006382	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698
65393006383	Gram-negative bacterial tonB protein; Region: TonB; cl10048
65393006384	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
65393006385	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
65393006386	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
65393006387	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65393006388	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65393006389	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
65393006390	active site
65393006391	catalytic residues [active]
65393006392	DNA binding site [nucleotide binding]
65393006393	Int/Topo IB signature motif; other site
65393006394	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
65393006395	Fatty acid desaturase; Region: FA_desaturase; pfam00487
65393006396	Di-iron ligands [ion binding]; other site
65393006397	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
65393006398	Prophage antirepressor [Transcription]; Region: COG3617
65393006399	BRO family, N-terminal domain; Region: Bro-N; smart01040
65393006400	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
65393006401	AAA domain; Region: AAA_30; pfam13604
65393006402	Family description; Region: UvrD_C_2; pfam13538
65393006403	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
65393006404	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65393006405	active site
65393006406	NTP binding site [chemical binding]; other site
65393006407	metal binding triad [ion binding]; metal-binding site
65393006408	antibiotic binding site [chemical binding]; other site
65393006409	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
65393006410	rod shape-determining protein MreB; Provisional; Region: PRK13930
65393006411	nucleotide binding site [chemical binding]; other site
65393006412	putative NEF/HSP70 interaction site [polypeptide binding]; other site
65393006413	SBD interface [polypeptide binding]; other site
65393006414	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
65393006415	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
65393006416	nucleotide binding site [chemical binding]; other site
65393006417	putative NEF/HSP70 interaction site [polypeptide binding]; other site
65393006418	SBD interface [polypeptide binding]; other site
65393006419	TPR repeat; Region: TPR_11; pfam13414
65393006420	Tetratricopeptide repeat; Region: TPR_2; pfam07719
65393006421	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
65393006422	Dynamin family; Region: Dynamin_N; pfam00350
65393006423	G1 box; other site
65393006424	GTP/Mg2+ binding site [chemical binding]; other site
65393006425	G2 box; other site
65393006426	Switch I region; other site
65393006427	G3 box; other site
65393006428	Switch II region; other site
65393006429	G4 box; other site
65393006430	G5 box; other site
65393006431	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
65393006432	Dynamin family; Region: Dynamin_N; pfam00350
65393006433	G1 box; other site
65393006434	GTP/Mg2+ binding site [chemical binding]; other site
65393006435	G2 box; other site
65393006436	Switch I region; other site
65393006437	G3 box; other site
65393006438	Switch II region; other site
65393006439	G4 box; other site
65393006440	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
65393006441	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
65393006442	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
65393006443	nucleotide binding site [chemical binding]; other site
65393006444	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393006445	putative active site [active]
65393006446	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393006447	putative active site [active]
65393006448	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
65393006449	RNA ligase; Region: RNA_lig_T4_1; pfam09511
65393006450	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
65393006451	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393006452	ATP binding site [chemical binding]; other site
65393006453	putative Mg++ binding site [ion binding]; other site
65393006454	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
65393006455	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393006456	Predicted transcriptional regulator [Transcription]; Region: COG2378
65393006457	WYL domain; Region: WYL; pfam13280
65393006458	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
65393006459	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
65393006460	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044
65393006461	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670
65393006462	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
65393006463	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
65393006464	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
65393006465	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
65393006466	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
65393006467	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
65393006468	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755
65393006469	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65393006470	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65393006471	active site
65393006472	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65393006473	active site
65393006474	NTP binding site [chemical binding]; other site
65393006475	metal binding triad [ion binding]; metal-binding site
65393006476	antibiotic binding site [chemical binding]; other site
65393006477	Protein of unknown function DUF86; Region: DUF86; cl01031
65393006478	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
65393006479	AAA-like domain; Region: AAA_10; pfam12846
65393006480	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
65393006481	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
65393006482	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
65393006483	DinB family; Region: DinB; cl17821
65393006484	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
65393006485	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
65393006486	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
65393006487	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
65393006488	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
65393006489	Coenzyme A binding pocket [chemical binding]; other site
65393006490	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
65393006491	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
65393006492	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
65393006493	active site
65393006494	interdomain interaction site; other site
65393006495	putative metal-binding site [ion binding]; other site
65393006496	nucleotide binding site [chemical binding]; other site
65393006497	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
65393006498	domain I; other site
65393006499	DNA binding groove [nucleotide binding]
65393006500	phosphate binding site [ion binding]; other site
65393006501	domain II; other site
65393006502	domain III; other site
65393006503	nucleotide binding site [chemical binding]; other site
65393006504	catalytic site [active]
65393006505	domain IV; other site
65393006506	PemK-like protein; Region: PemK; pfam02452
65393006507	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
65393006508	Mg binding site [ion binding]; other site
65393006509	nucleotide binding site [chemical binding]; other site
65393006510	putative protofilament interface [polypeptide binding]; other site
65393006511	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
65393006512	four helix bundle protein; Region: TIGR02436
65393006513	Methyltransferase domain; Region: Methyltransf_26; pfam13659
65393006514	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
65393006515	Helicase_C-like; Region: Helicase_C_4; pfam13871
65393006516	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
65393006517	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
65393006518	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
65393006519	active site
65393006520	catalytic residues [active]
65393006521	DNA binding site [nucleotide binding]
65393006522	Int/Topo IB signature motif; other site
65393006523	Domain of unknown function DUF21; Region: DUF21; pfam01595
65393006524	FOG: CBS domain [General function prediction only]; Region: COG0517
65393006525	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
65393006526	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393006527	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
65393006528	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65393006529	threonine synthase; Validated; Region: PRK06260
65393006530	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
65393006531	homodimer interface [polypeptide binding]; other site
65393006532	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393006533	catalytic residue [active]
65393006534	MoxR-like ATPases [General function prediction only]; Region: COG0714
65393006535	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393006536	ATP binding site [chemical binding]; other site
65393006537	Walker B motif; other site
65393006538	arginine finger; other site
65393006539	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
65393006540	gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529
65393006541	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
65393006542	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
65393006543	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
65393006544	catalytic triad [active]
65393006545	dimer interface [polypeptide binding]; other site
65393006546	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
65393006547	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
65393006548	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
65393006549	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
65393006550	dimerization interface [polypeptide binding]; other site
65393006551	DPS ferroxidase diiron center [ion binding]; other site
65393006552	ion pore; other site
65393006553	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
65393006554	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
65393006555	hypothetical protein; Provisional; Region: PRK06184
65393006556	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
65393006557	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
65393006558	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
65393006559	MutS domain I; Region: MutS_I; pfam01624
65393006560	MutS domain II; Region: MutS_II; pfam05188
65393006561	MutS domain III; Region: MutS_III; pfam05192
65393006562	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
65393006563	Walker A/P-loop; other site
65393006564	ATP binding site [chemical binding]; other site
65393006565	Q-loop/lid; other site
65393006566	ABC transporter signature motif; other site
65393006567	Walker B; other site
65393006568	D-loop; other site
65393006569	H-loop/switch region; other site
65393006570	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
65393006571	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
65393006572	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
65393006573	Protein of unknown function (DUF497); Region: DUF497; pfam04365
65393006574	Transposase [DNA replication, recombination, and repair]; Region: COG5421
65393006575	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
65393006576	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
65393006577	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
65393006578	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393006579	Walker A motif; other site
65393006580	ATP binding site [chemical binding]; other site
65393006581	Walker B motif; other site
65393006582	arginine finger; other site
65393006583	NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015
65393006584	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
65393006585	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
65393006586	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
65393006587	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65393006588	NADH dehydrogenase; Region: NADHdh; cl00469
65393006589	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
65393006590	Transglycosylase; Region: Transgly; pfam00912
65393006591	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
65393006592	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
65393006593	Predicted membrane protein [Function unknown]; Region: COG2119
65393006594	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
65393006595	Predicted membrane protein [Function unknown]; Region: COG2119
65393006596	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
65393006597	Flagellin N-methylase; Region: FliB; pfam03692
65393006598	hypothetical protein; Provisional; Region: PRK13686
65393006599	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
65393006600	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
65393006601	Protein of unknown function (DUF512); Region: DUF512; pfam04459
65393006602	light-harvesting-like protein 3; Provisional; Region: PLN00014
65393006603	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
65393006604	dimerization interface [polypeptide binding]; other site
65393006605	putative DNA binding site [nucleotide binding]; other site
65393006606	putative Zn2+ binding site [ion binding]; other site
65393006607	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
65393006608	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
65393006609	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
65393006610	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
65393006611	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
65393006612	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
65393006613	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
65393006614	ABC-ATPase subunit  interface; other site
65393006615	dimer interface [polypeptide binding]; other site
65393006616	putative PBP binding regions; other site
65393006617	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
65393006618	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
65393006619	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
65393006620	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
65393006621	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
65393006622	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
65393006623	metal binding site [ion binding]; metal-binding site
65393006624	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
65393006625	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
65393006626	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
65393006627	RNA binding surface [nucleotide binding]; other site
65393006628	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
65393006629	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
65393006630	Ligand binding site; other site
65393006631	Putative Catalytic site; other site
65393006632	DXD motif; other site
65393006633	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
65393006634	active site
65393006635	SAM binding site [chemical binding]; other site
65393006636	homodimer interface [polypeptide binding]; other site
65393006637	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
65393006638	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
65393006639	active site
65393006640	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
65393006641	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
65393006642	TPR repeat; Region: TPR_11; pfam13414
65393006643	TPR repeat; Region: TPR_11; pfam13414
65393006644	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393006645	binding surface
65393006646	TPR motif; other site
65393006647	TPR repeat; Region: TPR_11; pfam13414
65393006648	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393006649	TPR motif; other site
65393006650	binding surface
65393006651	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393006652	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393006653	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393006654	binding surface
65393006655	TPR motif; other site
65393006656	TPR repeat; Region: TPR_11; pfam13414
65393006657	HEAT repeats; Region: HEAT_2; pfam13646
65393006658	HEAT repeats; Region: HEAT_2; pfam13646
65393006659	HEAT repeats; Region: HEAT_2; pfam13646
65393006660	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393006661	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
65393006662	hypothetical protein; Provisional; Region: PRK07377
65393006663	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
65393006664	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
65393006665	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
65393006666	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65393006667	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389
65393006668	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393006669	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393006670	ligand binding site [chemical binding]; other site
65393006671	flexible hinge region; other site
65393006672	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
65393006673	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
65393006674	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
65393006675	metal binding site [ion binding]; metal-binding site
65393006676	SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833
65393006677	active site
65393006678	catalytic triad [active]
65393006679	oxyanion hole [active]
65393006680	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393006681	META domain; Region: META; pfam03724
65393006682	META domain; Region: META; pfam03724
65393006683	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
65393006684	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
65393006685	Ligand Binding Site [chemical binding]; other site
65393006686	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
65393006687	active site
65393006688	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
65393006689	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
65393006690	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
65393006691	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
65393006692	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
65393006693	putative active site [active]
65393006694	putative NTP binding site [chemical binding]; other site
65393006695	putative nucleic acid binding site [nucleotide binding]; other site
65393006696	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
65393006697	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
65393006698	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
65393006699	catalytic triad [active]
65393006700	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
65393006701	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
65393006702	Walker A/P-loop; other site
65393006703	ATP binding site [chemical binding]; other site
65393006704	Q-loop/lid; other site
65393006705	ABC transporter signature motif; other site
65393006706	Walker B; other site
65393006707	D-loop; other site
65393006708	H-loop/switch region; other site
65393006709	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
65393006710	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
65393006711	metal binding site [ion binding]; metal-binding site
65393006712	nucleotidyl binding site; other site
65393006713	Archaeal ATPase; Region: Arch_ATPase; pfam01637
65393006714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393006715	Walker A motif; other site
65393006716	ATP binding site [chemical binding]; other site
65393006717	Walker B motif; other site
65393006718	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393006719	structural tetrad; other site
65393006720	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393006721	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393006722	structural tetrad; other site
65393006723	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393006724	structural tetrad; other site
65393006725	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
65393006726	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
65393006727	putative catalytic cysteine [active]
65393006728	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
65393006729	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
65393006730	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
65393006731	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393006732	ATP binding site [chemical binding]; other site
65393006733	putative Mg++ binding site [ion binding]; other site
65393006734	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65393006735	nucleotide binding region [chemical binding]; other site
65393006736	ATP-binding site [chemical binding]; other site
65393006737	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
65393006738	Glycoprotease family; Region: Peptidase_M22; pfam00814
65393006739	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393006740	S-adenosylmethionine binding site [chemical binding]; other site
65393006741	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
65393006742	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393006743	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393006744	structural tetrad; other site
65393006745	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
65393006746	MgtE intracellular N domain; Region: MgtE_N; smart00924
65393006747	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
65393006748	Divalent cation transporter; Region: MgtE; pfam01769
65393006749	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
65393006750	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
65393006751	HemN C-terminal domain; Region: HemN_C; pfam06969
65393006752	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
65393006753	heme binding pocket [chemical binding]; other site
65393006754	heme ligand [chemical binding]; other site
65393006755	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
65393006756	diiron binding motif [ion binding]; other site
65393006757	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
65393006758	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
65393006759	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
65393006760	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
65393006761	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
65393006762	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
65393006763	Surface antigen; Region: Bac_surface_Ag; pfam01103
65393006764	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
65393006765	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
65393006766	ATP binding site [chemical binding]; other site
65393006767	active site
65393006768	substrate binding site [chemical binding]; other site
65393006769	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
65393006770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393006771	dimer interface [polypeptide binding]; other site
65393006772	conserved gate region; other site
65393006773	putative PBP binding loops; other site
65393006774	ABC-ATPase subunit interface; other site
65393006775	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65393006776	active site
65393006777	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
65393006778	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
65393006779	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
65393006780	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
65393006781	FMN binding site [chemical binding]; other site
65393006782	active site
65393006783	substrate binding site [chemical binding]; other site
65393006784	catalytic residue [active]
65393006785	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
65393006786	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
65393006787	core domain interface [polypeptide binding]; other site
65393006788	delta subunit interface [polypeptide binding]; other site
65393006789	epsilon subunit interface [polypeptide binding]; other site
65393006790	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
65393006791	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
65393006792	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
65393006793	beta subunit interaction interface [polypeptide binding]; other site
65393006794	Walker A motif; other site
65393006795	ATP binding site [chemical binding]; other site
65393006796	Walker B motif; other site
65393006797	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
65393006798	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
65393006799	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
65393006800	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
65393006801	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
65393006802	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
65393006803	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
65393006804	F0F1 ATP synthase subunit C; Validated; Region: PRK07354
65393006805	ATP synthase CF0 A subunit; Region: atpI; CHL00046
65393006806	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
65393006807	ATP synthase I chain; Region: ATP_synt_I; pfam03899
65393006808	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393006809	binding surface
65393006810	TPR motif; other site
65393006811	TPR repeat; Region: TPR_11; pfam13414
65393006812	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
65393006813	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
65393006814	XisI protein; Region: XisI; pfam08869
65393006815	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65393006816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393006817	S-adenosylmethionine binding site [chemical binding]; other site
65393006818	phycobillisome linker protein; Region: apcE; CHL00091
65393006819	Phycobilisome protein; Region: Phycobilisome; cl08227
65393006820	Phycobilisome protein; Region: Phycobilisome; cl08227
65393006821	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65393006822	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65393006823	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65393006824	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393006825	putative active site [active]
65393006826	Phycobilisome protein; Region: Phycobilisome; cl08227
65393006827	allophycocyanin beta subunit; Region: apcB; CHL00088
65393006828	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
65393006829	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
65393006830	NACHT domain; Region: NACHT; pfam05729
65393006831	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
65393006832	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
65393006833	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
65393006834	phosphate binding site [ion binding]; other site
65393006835	putative substrate binding pocket [chemical binding]; other site
65393006836	dimer interface [polypeptide binding]; other site
65393006837	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
65393006838	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
65393006839	putative active site [active]
65393006840	dimerization interface [polypeptide binding]; other site
65393006841	putative tRNAtyr binding site [nucleotide binding]; other site
65393006842	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
65393006843	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
65393006844	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
65393006845	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393006846	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393006847	ligand binding site [chemical binding]; other site
65393006848	flexible hinge region; other site
65393006849	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65393006850	catalytic core [active]
65393006851	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65393006852	catalytic core [active]
65393006853	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
65393006854	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
65393006855	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393006856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393006857	active site
65393006858	phosphorylation site [posttranslational modification]
65393006859	intermolecular recognition site; other site
65393006860	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
65393006861	ornithine carbamoyltransferase; Provisional; Region: PRK00779
65393006862	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
65393006863	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
65393006864	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
65393006865	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
65393006866	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
65393006867	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
65393006868	putative dimer interface [polypeptide binding]; other site
65393006869	putative anticodon binding site; other site
65393006870	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
65393006871	homodimer interface [polypeptide binding]; other site
65393006872	motif 1; other site
65393006873	motif 2; other site
65393006874	active site
65393006875	motif 3; other site
65393006876	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393006877	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393006878	binding surface
65393006879	TPR motif; other site
65393006880	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
65393006881	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393006882	binding surface
65393006883	TPR motif; other site
65393006884	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393006885	binding surface
65393006886	TPR motif; other site
65393006887	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393006888	binding surface
65393006889	TPR motif; other site
65393006890	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
65393006891	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393006892	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
65393006893	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393006894	active site
65393006895	motif I; other site
65393006896	motif II; other site
65393006897	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
65393006898	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
65393006899	putative active site [active]
65393006900	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65393006901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393006902	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393006903	Probable transposase; Region: OrfB_IS605; pfam01385
65393006904	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393006905	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
65393006906	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
65393006907	dimerization interface [polypeptide binding]; other site
65393006908	active site
65393006909	metal binding site [ion binding]; metal-binding site
65393006910	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
65393006911	dsRNA binding site [nucleotide binding]; other site
65393006912	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
65393006913	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
65393006914	oligomer interface [polypeptide binding]; other site
65393006915	metal binding site [ion binding]; metal-binding site
65393006916	metal binding site [ion binding]; metal-binding site
65393006917	Cl binding site [ion binding]; other site
65393006918	aspartate ring; other site
65393006919	basic sphincter; other site
65393006920	putative hydrophobic gate; other site
65393006921	periplasmic entrance; other site
65393006922	pyranose oxidase; Region: pyranose_ox; TIGR02462
65393006923	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
65393006924	dimer interface [polypeptide binding]; other site
65393006925	catalytic triad [active]
65393006926	Predicted RNA binding protein (dsRBD-like fold), HicA family    [General function prediction only]; Region: COG1724
65393006927	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65393006928	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
65393006929	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
65393006930	substrate binding site [chemical binding]; other site
65393006931	active site
65393006932	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
65393006933	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393006934	NAD(P) binding site [chemical binding]; other site
65393006935	active site
65393006936	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393006937	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
65393006938	putative ADP-binding pocket [chemical binding]; other site
65393006939	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
65393006940	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
65393006941	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
65393006942	active site
65393006943	nucleophile elbow; other site
65393006944	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
65393006945	nucleotide binding site [chemical binding]; other site
65393006946	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393006947	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393006948	ligand binding site [chemical binding]; other site
65393006949	flexible hinge region; other site
65393006950	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
65393006951	putative switch regulator; other site
65393006952	non-specific DNA interactions [nucleotide binding]; other site
65393006953	DNA binding site [nucleotide binding]
65393006954	sequence specific DNA binding site [nucleotide binding]; other site
65393006955	putative cAMP binding site [chemical binding]; other site
65393006956	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
65393006957	Cytochrome P450; Region: p450; cl12078
65393006958	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
65393006959	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
65393006960	active site pocket [active]
65393006961	putative dimer interface [polypeptide binding]; other site
65393006962	putative cataytic base [active]
65393006963	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393006964	putative active site [active]
65393006965	proline aminopeptidase P II; Provisional; Region: PRK10879
65393006966	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
65393006967	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
65393006968	active site
65393006969	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
65393006970	Rhomboid family; Region: Rhomboid; pfam01694
65393006971	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
65393006972	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
65393006973	NAD binding site [chemical binding]; other site
65393006974	dimerization interface [polypeptide binding]; other site
65393006975	product binding site; other site
65393006976	substrate binding site [chemical binding]; other site
65393006977	zinc binding site [ion binding]; other site
65393006978	catalytic residues [active]
65393006979	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393006980	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393006981	active site
65393006982	ATP binding site [chemical binding]; other site
65393006983	substrate binding site [chemical binding]; other site
65393006984	activation loop (A-loop); other site
65393006985	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393006986	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393006987	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393006988	dimer interface [polypeptide binding]; other site
65393006989	phosphorylation site [posttranslational modification]
65393006990	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393006991	ATP binding site [chemical binding]; other site
65393006992	Mg2+ binding site [ion binding]; other site
65393006993	G-X-G motif; other site
65393006994	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
65393006995	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65393006996	FOG: CBS domain [General function prediction only]; Region: COG0517
65393006997	FOG: CBS domain [General function prediction only]; Region: COG0517
65393006998	FOG: CBS domain [General function prediction only]; Region: COG0517
65393006999	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
65393007000	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393007001	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
65393007002	putative active site [active]
65393007003	heme pocket [chemical binding]; other site
65393007004	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393007005	dimer interface [polypeptide binding]; other site
65393007006	phosphorylation site [posttranslational modification]
65393007007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393007008	ATP binding site [chemical binding]; other site
65393007009	Mg2+ binding site [ion binding]; other site
65393007010	G-X-G motif; other site
65393007011	Response regulator receiver domain; Region: Response_reg; pfam00072
65393007012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007013	active site
65393007014	phosphorylation site [posttranslational modification]
65393007015	intermolecular recognition site; other site
65393007016	dimerization interface [polypeptide binding]; other site
65393007017	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
65393007018	catalytic triad [active]
65393007019	conserved cis-peptide bond; other site
65393007020	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65393007021	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
65393007022	cofactor binding site; other site
65393007023	DNA binding site [nucleotide binding]
65393007024	substrate interaction site [chemical binding]; other site
65393007025	agmatinase; Region: agmatinase; TIGR01230
65393007026	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
65393007027	putative active site [active]
65393007028	Mn binding site [ion binding]; other site
65393007029	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
65393007030	putative nucleotide binding site [chemical binding]; other site
65393007031	uridine monophosphate binding site [chemical binding]; other site
65393007032	homohexameric interface [polypeptide binding]; other site
65393007033	ribosome recycling factor; Reviewed; Region: frr; PRK00083
65393007034	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
65393007035	hinge region; other site
65393007036	Homeodomain-like domain; Region: HTH_23; pfam13384
65393007037	Winged helix-turn helix; Region: HTH_29; pfam13551
65393007038	Homeodomain-like domain; Region: HTH_32; pfam13565
65393007039	DDE superfamily endonuclease; Region: DDE_3; pfam13358
65393007040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
65393007041	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
65393007042	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65393007043	Walker A/P-loop; other site
65393007044	ATP binding site [chemical binding]; other site
65393007045	Q-loop/lid; other site
65393007046	ABC transporter signature motif; other site
65393007047	Walker B; other site
65393007048	D-loop; other site
65393007049	H-loop/switch region; other site
65393007050	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65393007051	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
65393007052	Walker A/P-loop; other site
65393007053	ATP binding site [chemical binding]; other site
65393007054	Q-loop/lid; other site
65393007055	ABC transporter signature motif; other site
65393007056	Walker B; other site
65393007057	D-loop; other site
65393007058	H-loop/switch region; other site
65393007059	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
65393007060	Helix-turn-helix domain; Region: HTH_17; pfam12728
65393007061	DNA methylase; Region: N6_N4_Mtase; pfam01555
65393007062	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
65393007063	Predicted membrane protein [Function unknown]; Region: COG4244
65393007064	methionine sulfoxide reductase A; Provisional; Region: PRK13014
65393007065	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
65393007066	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
65393007067	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
65393007068	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
65393007069	glutamine binding [chemical binding]; other site
65393007070	catalytic triad [active]
65393007071	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
65393007072	metal-binding heat shock protein; Provisional; Region: PRK00016
65393007073	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
65393007074	peptide chain release factor 2; Validated; Region: prfB; PRK00578
65393007075	This domain is found in peptide chain release factors; Region: PCRF; smart00937
65393007076	RF-1 domain; Region: RF-1; pfam00472
65393007077	TMAO/DMSO reductase; Reviewed; Region: PRK05363
65393007078	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
65393007079	Moco binding site; other site
65393007080	metal coordination site [ion binding]; other site
65393007081	Uncharacterized conserved protein [Function unknown]; Region: COG5607
65393007082	E3 Ubiquitin ligase; Region: GIDE; pfam12483
65393007083	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
65393007084	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
65393007085	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
65393007086	active site
65393007087	HIGH motif; other site
65393007088	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
65393007089	KMSKS motif; other site
65393007090	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
65393007091	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393007092	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393007093	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393007094	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393007095	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
65393007096	Lipase (class 2); Region: Lipase_2; pfam01674
65393007097	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65393007098	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393007099	S-adenosylmethionine binding site [chemical binding]; other site
65393007100	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
65393007101	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
65393007102	Walker A/P-loop; other site
65393007103	ATP binding site [chemical binding]; other site
65393007104	Q-loop/lid; other site
65393007105	ABC transporter signature motif; other site
65393007106	Walker B; other site
65393007107	D-loop; other site
65393007108	H-loop/switch region; other site
65393007109	DevC protein; Region: devC; TIGR01185
65393007110	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
65393007111	FtsX-like permease family; Region: FtsX; pfam02687
65393007112	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
65393007113	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65393007114	HlyD family secretion protein; Region: HlyD_3; pfam13437
65393007115	Phospholipid methyltransferase; Region: PEMT; cl17370
65393007116	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
65393007117	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
65393007118	malonyl-CoA binding site [chemical binding]; other site
65393007119	dimer interface [polypeptide binding]; other site
65393007120	active site
65393007121	product binding site; other site
65393007122	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
65393007123	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
65393007124	active site
65393007125	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
65393007126	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
65393007127	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393007128	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
65393007129	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
65393007130	acyl-CoA synthetase; Validated; Region: PRK05850
65393007131	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
65393007132	acyl-activating enzyme (AAE) consensus motif; other site
65393007133	active site
65393007134	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
65393007135	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
65393007136	NAD(P) binding site [chemical binding]; other site
65393007137	catalytic residues [active]
65393007138	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393007139	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393007140	active site
65393007141	ATP binding site [chemical binding]; other site
65393007142	substrate binding site [chemical binding]; other site
65393007143	activation loop (A-loop); other site
65393007144	AAA ATPase domain; Region: AAA_16; pfam13191
65393007145	Predicted ATPase [General function prediction only]; Region: COG3899
65393007146	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393007147	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393007148	PAS fold; Region: PAS_4; pfam08448
65393007149	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393007150	putative active site [active]
65393007151	heme pocket [chemical binding]; other site
65393007152	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
65393007153	dimer interface [polypeptide binding]; other site
65393007154	[2Fe-2S] cluster binding site [ion binding]; other site
65393007155	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
65393007156	MoaE homodimer interface [polypeptide binding]; other site
65393007157	MoaD interaction [polypeptide binding]; other site
65393007158	active site residues [active]
65393007159	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
65393007160	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
65393007161	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
65393007162	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
65393007163	GUN4-like; Region: GUN4; pfam05419
65393007164	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
65393007165	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
65393007166	HlyD family secretion protein; Region: HlyD_3; pfam13437
65393007167	proton extrusion protein PcxA; Provisional; Region: PRK02507
65393007168	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
65393007169	Protein export membrane protein; Region: SecD_SecF; cl14618
65393007170	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65393007171	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
65393007172	Hexamer interface [polypeptide binding]; other site
65393007173	Hexagonal pore residue; other site
65393007174	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
65393007175	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
65393007176	Hexamer interface [polypeptide binding]; other site
65393007177	Hexagonal pore residue; other site
65393007178	Protein of unknown function (DUF433); Region: DUF433; cl01030
65393007179	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
65393007180	NACHT domain; Region: NACHT; pfam05729
65393007181	Walker A motif; other site
65393007182	ATP binding site [chemical binding]; other site
65393007183	Walker B motif; other site
65393007184	HEAT repeats; Region: HEAT_2; pfam13646
65393007185	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393007186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007187	active site
65393007188	phosphorylation site [posttranslational modification]
65393007189	intermolecular recognition site; other site
65393007190	dimerization interface [polypeptide binding]; other site
65393007191	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393007192	DNA binding site [nucleotide binding]
65393007193	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65393007194	putative binding surface; other site
65393007195	active site
65393007196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007197	active site
65393007198	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
65393007199	phosphorylation site [posttranslational modification]
65393007200	intermolecular recognition site; other site
65393007201	dimerization interface [polypeptide binding]; other site
65393007202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007203	active site
65393007204	phosphorylation site [posttranslational modification]
65393007205	intermolecular recognition site; other site
65393007206	dimerization interface [polypeptide binding]; other site
65393007207	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393007208	metal binding site [ion binding]; metal-binding site
65393007209	active site
65393007210	I-site; other site
65393007211	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
65393007212	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393007213	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
65393007214	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
65393007215	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
65393007216	putative NAD(P) binding site [chemical binding]; other site
65393007217	active site
65393007218	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
65393007219	homotrimer interaction site [polypeptide binding]; other site
65393007220	zinc binding site [ion binding]; other site
65393007221	CDP-binding sites; other site
65393007222	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
65393007223	active site
65393007224	catalytic motif [active]
65393007225	Zn binding site [ion binding]; other site
65393007226	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65393007227	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65393007228	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
65393007229	Fatty acid desaturase; Region: FA_desaturase; pfam00487
65393007230	putative di-iron ligands [ion binding]; other site
65393007231	Cupin domain; Region: Cupin_2; pfam07883
65393007232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
65393007233	hypothetical protein; Reviewed; Region: PRK09588
65393007234	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
65393007235	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
65393007236	Domain of unknown function DUF20; Region: UPF0118; pfam01594
65393007237	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
65393007238	Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899
65393007239	hypothetical protein; Validated; Region: PRK00110
65393007240	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
65393007241	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
65393007242	active site
65393007243	substrate-binding site [chemical binding]; other site
65393007244	metal-binding site [ion binding]
65393007245	ATP binding site [chemical binding]; other site
65393007246	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
65393007247	phosphoenolpyruvate synthase; Validated; Region: PRK06241
65393007248	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
65393007249	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
65393007250	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
65393007251	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
65393007252	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65393007253	putative binding surface; other site
65393007254	active site
65393007255	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65393007256	putative binding surface; other site
65393007257	active site
65393007258	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65393007259	putative binding surface; other site
65393007260	active site
65393007261	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
65393007262	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
65393007263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393007264	ATP binding site [chemical binding]; other site
65393007265	Mg2+ binding site [ion binding]; other site
65393007266	G-X-G motif; other site
65393007267	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
65393007268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007269	Response regulator receiver domain; Region: Response_reg; pfam00072
65393007270	active site
65393007271	phosphorylation site [posttranslational modification]
65393007272	intermolecular recognition site; other site
65393007273	dimerization interface [polypeptide binding]; other site
65393007274	HAMP domain; Region: HAMP; pfam00672
65393007275	dimerization interface [polypeptide binding]; other site
65393007276	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393007277	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393007278	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65393007279	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65393007280	dimer interface [polypeptide binding]; other site
65393007281	putative CheW interface [polypeptide binding]; other site
65393007282	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393007283	dimerization interface [polypeptide binding]; other site
65393007284	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393007285	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393007286	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393007287	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393007288	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
65393007289	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65393007290	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65393007291	dimer interface [polypeptide binding]; other site
65393007292	putative CheW interface [polypeptide binding]; other site
65393007293	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
65393007294	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
65393007295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007296	Response regulator receiver domain; Region: Response_reg; pfam00072
65393007297	active site
65393007298	phosphorylation site [posttranslational modification]
65393007299	intermolecular recognition site; other site
65393007300	dimerization interface [polypeptide binding]; other site
65393007301	Response regulator receiver domain; Region: Response_reg; pfam00072
65393007302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007303	active site
65393007304	phosphorylation site [posttranslational modification]
65393007305	intermolecular recognition site; other site
65393007306	dimerization interface [polypeptide binding]; other site
65393007307	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65393007308	putative binding surface; other site
65393007309	active site
65393007310	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
65393007311	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
65393007312	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393007313	ATP binding site [chemical binding]; other site
65393007314	Mg2+ binding site [ion binding]; other site
65393007315	G-X-G motif; other site
65393007316	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
65393007317	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393007318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007319	active site
65393007320	phosphorylation site [posttranslational modification]
65393007321	intermolecular recognition site; other site
65393007322	dimerization interface [polypeptide binding]; other site
65393007323	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393007324	dimerization interface [polypeptide binding]; other site
65393007325	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65393007326	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65393007327	dimer interface [polypeptide binding]; other site
65393007328	putative CheW interface [polypeptide binding]; other site
65393007329	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
65393007330	Response regulator receiver domain; Region: Response_reg; pfam00072
65393007331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007332	active site
65393007333	phosphorylation site [posttranslational modification]
65393007334	intermolecular recognition site; other site
65393007335	dimerization interface [polypeptide binding]; other site
65393007336	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
65393007337	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
65393007338	Walker A/P-loop; other site
65393007339	ATP binding site [chemical binding]; other site
65393007340	Q-loop/lid; other site
65393007341	ABC transporter signature motif; other site
65393007342	Walker B; other site
65393007343	D-loop; other site
65393007344	H-loop/switch region; other site
65393007345	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65393007346	Major Facilitator Superfamily; Region: MFS_1; pfam07690
65393007347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393007348	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
65393007349	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
65393007350	Predicted GTPase [General function prediction only]; Region: COG2403
65393007351	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
65393007352	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65393007353	PBP superfamily domain; Region: PBP_like_2; cl17296
65393007354	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
65393007355	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
65393007356	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393007357	dimer interface [polypeptide binding]; other site
65393007358	conserved gate region; other site
65393007359	putative PBP binding loops; other site
65393007360	ABC-ATPase subunit interface; other site
65393007361	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
65393007362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393007363	dimer interface [polypeptide binding]; other site
65393007364	conserved gate region; other site
65393007365	putative PBP binding loops; other site
65393007366	ABC-ATPase subunit interface; other site
65393007367	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
65393007368	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
65393007369	Walker A/P-loop; other site
65393007370	ATP binding site [chemical binding]; other site
65393007371	Q-loop/lid; other site
65393007372	ABC transporter signature motif; other site
65393007373	Walker B; other site
65393007374	D-loop; other site
65393007375	H-loop/switch region; other site
65393007376	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
65393007377	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
65393007378	Walker A/P-loop; other site
65393007379	ATP binding site [chemical binding]; other site
65393007380	Q-loop/lid; other site
65393007381	ABC transporter signature motif; other site
65393007382	Walker B; other site
65393007383	D-loop; other site
65393007384	H-loop/switch region; other site
65393007385	PBP superfamily domain; Region: PBP_like_2; cl17296
65393007386	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
65393007387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393007388	dimer interface [polypeptide binding]; other site
65393007389	conserved gate region; other site
65393007390	ABC-ATPase subunit interface; other site
65393007391	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
65393007392	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
65393007393	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393007394	ABC-ATPase subunit interface; other site
65393007395	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
65393007396	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
65393007397	Walker A/P-loop; other site
65393007398	ATP binding site [chemical binding]; other site
65393007399	Q-loop/lid; other site
65393007400	ABC transporter signature motif; other site
65393007401	Walker B; other site
65393007402	D-loop; other site
65393007403	H-loop/switch region; other site
65393007404	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
65393007405	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
65393007406	dimer interface [polypeptide binding]; other site
65393007407	tetramer interface [polypeptide binding]; other site
65393007408	PYR/PP interface [polypeptide binding]; other site
65393007409	TPP binding site [chemical binding]; other site
65393007410	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
65393007411	TPP-binding site; other site
65393007412	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
65393007413	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
65393007414	active site
65393007415	nucleophile elbow; other site
65393007416	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
65393007417	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
65393007418	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
65393007419	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393007420	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65393007421	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393007422	DNA binding residues [nucleotide binding]
65393007423	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
65393007424	ribosomal protein S14; Region: rps14; CHL00074
65393007425	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
65393007426	RNA polymerase sigma factor; Validated; Region: PRK05949
65393007427	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
65393007428	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393007429	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65393007430	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393007431	DNA binding residues [nucleotide binding]
65393007432	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
65393007433	ligand-binding site [chemical binding]; other site
65393007434	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65393007435	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
65393007436	active site
65393007437	metal binding site [ion binding]; metal-binding site
65393007438	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
65393007439	TrkA-N domain; Region: TrkA_N; pfam02254
65393007440	TrkA-C domain; Region: TrkA_C; pfam02080
65393007441	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
65393007442	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
65393007443	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393007444	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65393007445	H+ Antiporter protein; Region: 2A0121; TIGR00900
65393007446	Recombination protein O N terminal; Region: RecO_N; pfam11967
65393007447	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
65393007448	Recombination protein O C terminal; Region: RecO_C; pfam02565
65393007449	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
65393007450	intersubunit interface [polypeptide binding]; other site
65393007451	active site
65393007452	catalytic residue [active]
65393007453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393007454	S-adenosylmethionine binding site [chemical binding]; other site
65393007455	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
65393007456	dimanganese center [ion binding]; other site
65393007457	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
65393007458	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393007459	FeS/SAM binding site; other site
65393007460	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
65393007461	Pyruvate formate lyase 1; Region: PFL1; cd01678
65393007462	coenzyme A binding site [chemical binding]; other site
65393007463	active site
65393007464	catalytic residues [active]
65393007465	glycine loop; other site
65393007466	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
65393007467	PAS fold; Region: PAS_4; pfam08448
65393007468	PAS domain S-box; Region: sensory_box; TIGR00229
65393007469	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393007470	putative active site [active]
65393007471	heme pocket [chemical binding]; other site
65393007472	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393007473	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393007474	PAS domain; Region: PAS_9; pfam13426
65393007475	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393007476	PAS fold; Region: PAS_3; pfam08447
65393007477	putative active site [active]
65393007478	heme pocket [chemical binding]; other site
65393007479	PAS domain S-box; Region: sensory_box; TIGR00229
65393007480	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393007481	PAS fold; Region: PAS_3; pfam08447
65393007482	putative active site [active]
65393007483	heme pocket [chemical binding]; other site
65393007484	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393007485	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393007486	dimer interface [polypeptide binding]; other site
65393007487	phosphorylation site [posttranslational modification]
65393007488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393007489	ATP binding site [chemical binding]; other site
65393007490	Mg2+ binding site [ion binding]; other site
65393007491	G-X-G motif; other site
65393007492	Response regulator receiver domain; Region: Response_reg; pfam00072
65393007493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007494	active site
65393007495	phosphorylation site [posttranslational modification]
65393007496	intermolecular recognition site; other site
65393007497	dimerization interface [polypeptide binding]; other site
65393007498	Haemolytic domain; Region: Haemolytic; pfam01809
65393007499	Response regulator receiver domain; Region: Response_reg; pfam00072
65393007500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007501	active site
65393007502	phosphorylation site [posttranslational modification]
65393007503	intermolecular recognition site; other site
65393007504	dimerization interface [polypeptide binding]; other site
65393007505	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393007506	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393007507	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393007508	dimer interface [polypeptide binding]; other site
65393007509	phosphorylation site [posttranslational modification]
65393007510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393007511	ATP binding site [chemical binding]; other site
65393007512	Mg2+ binding site [ion binding]; other site
65393007513	G-X-G motif; other site
65393007514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007515	Response regulator receiver domain; Region: Response_reg; pfam00072
65393007516	active site
65393007517	phosphorylation site [posttranslational modification]
65393007518	intermolecular recognition site; other site
65393007519	dimerization interface [polypeptide binding]; other site
65393007520	Response regulator receiver domain; Region: Response_reg; pfam00072
65393007521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007522	active site
65393007523	phosphorylation site [posttranslational modification]
65393007524	intermolecular recognition site; other site
65393007525	dimerization interface [polypeptide binding]; other site
65393007526	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65393007527	putative binding surface; other site
65393007528	active site
65393007529	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393007530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007531	active site
65393007532	phosphorylation site [posttranslational modification]
65393007533	intermolecular recognition site; other site
65393007534	dimerization interface [polypeptide binding]; other site
65393007535	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393007536	DNA binding site [nucleotide binding]
65393007537	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393007538	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393007539	dimerization interface [polypeptide binding]; other site
65393007540	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393007541	dimer interface [polypeptide binding]; other site
65393007542	phosphorylation site [posttranslational modification]
65393007543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393007544	ATP binding site [chemical binding]; other site
65393007545	Mg2+ binding site [ion binding]; other site
65393007546	G-X-G motif; other site
65393007547	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
65393007548	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
65393007549	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
65393007550	NAD(P) binding site [chemical binding]; other site
65393007551	homotetramer interface [polypeptide binding]; other site
65393007552	homodimer interface [polypeptide binding]; other site
65393007553	active site
65393007554	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
65393007555	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
65393007556	ring oligomerisation interface [polypeptide binding]; other site
65393007557	ATP/Mg binding site [chemical binding]; other site
65393007558	stacking interactions; other site
65393007559	hinge regions; other site
65393007560	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
65393007561	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
65393007562	heat shock protein 90; Provisional; Region: PRK05218
65393007563	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393007564	ATP binding site [chemical binding]; other site
65393007565	Mg2+ binding site [ion binding]; other site
65393007566	G-X-G motif; other site
65393007567	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
65393007568	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
65393007569	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
65393007570	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
65393007571	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
65393007572	N-acetyl-D-glucosamine binding site [chemical binding]; other site
65393007573	catalytic residue [active]
65393007574	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774
65393007575	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
65393007576	PIN domain; Region: PIN_3; cl17397
65393007577	NB-ARC domain; Region: NB-ARC; pfam00931
65393007578	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
65393007579	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
65393007580	active site
65393007581	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
65393007582	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
65393007583	putative ligand binding site [chemical binding]; other site
65393007584	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
65393007585	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
65393007586	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
65393007587	TM-ABC transporter signature motif; other site
65393007588	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
65393007589	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
65393007590	TM-ABC transporter signature motif; other site
65393007591	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
65393007592	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
65393007593	Walker A/P-loop; other site
65393007594	ATP binding site [chemical binding]; other site
65393007595	Q-loop/lid; other site
65393007596	ABC transporter signature motif; other site
65393007597	Walker B; other site
65393007598	D-loop; other site
65393007599	H-loop/switch region; other site
65393007600	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
65393007601	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
65393007602	Walker A/P-loop; other site
65393007603	ATP binding site [chemical binding]; other site
65393007604	Q-loop/lid; other site
65393007605	ABC transporter signature motif; other site
65393007606	Walker B; other site
65393007607	D-loop; other site
65393007608	H-loop/switch region; other site
65393007609	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
65393007610	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
65393007611	Fasciclin domain; Region: Fasciclin; pfam02469
65393007612	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
65393007613	active site
65393007614	multimer interface [polypeptide binding]; other site
65393007615	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
65393007616	DHH family; Region: DHH; pfam01368
65393007617	DHHA1 domain; Region: DHHA1; pfam02272
65393007618	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
65393007619	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
65393007620	Ligand binding site; other site
65393007621	Putative Catalytic site; other site
65393007622	DXD motif; other site
65393007623	Transcriptional regulator [Transcription]; Region: LytR; COG1316
65393007624	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
65393007625	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
65393007626	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
65393007627	substrate binding pocket [chemical binding]; other site
65393007628	membrane-bound complex binding site; other site
65393007629	hinge residues; other site
65393007630	NB-ARC domain; Region: NB-ARC; pfam00931
65393007631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393007632	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393007633	TPR motif; other site
65393007634	binding surface
65393007635	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393007636	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393007637	binding surface
65393007638	TPR motif; other site
65393007639	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393007640	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393007641	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393007642	binding surface
65393007643	TPR motif; other site
65393007644	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393007645	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393007646	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393007647	binding surface
65393007648	TPR motif; other site
65393007649	flavodoxin FldA; Validated; Region: PRK09267
65393007650	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
65393007651	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
65393007652	catalytic site [active]
65393007653	GMP synthase; Reviewed; Region: guaA; PRK00074
65393007654	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
65393007655	AMP/PPi binding site [chemical binding]; other site
65393007656	candidate oxyanion hole; other site
65393007657	catalytic triad [active]
65393007658	potential glutamine specificity residues [chemical binding]; other site
65393007659	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
65393007660	ATP Binding subdomain [chemical binding]; other site
65393007661	Ligand Binding sites [chemical binding]; other site
65393007662	Dimerization subdomain; other site
65393007663	response regulator FixJ; Provisional; Region: fixJ; PRK09390
65393007664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007665	active site
65393007666	phosphorylation site [posttranslational modification]
65393007667	intermolecular recognition site; other site
65393007668	dimerization interface [polypeptide binding]; other site
65393007669	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393007670	DNA binding residues [nucleotide binding]
65393007671	dimerization interface [polypeptide binding]; other site
65393007672	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
65393007673	dimer interface [polypeptide binding]; other site
65393007674	[2Fe-2S] cluster binding site [ion binding]; other site
65393007675	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
65393007676	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
65393007677	nucleotide binding pocket [chemical binding]; other site
65393007678	K-X-D-G motif; other site
65393007679	catalytic site [active]
65393007680	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
65393007681	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
65393007682	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
65393007683	Dimer interface [polypeptide binding]; other site
65393007684	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
65393007685	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393007686	putative active site [active]
65393007687	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
65393007688	nudix motif; other site
65393007689	argininosuccinate lyase; Provisional; Region: PRK00855
65393007690	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
65393007691	active sites [active]
65393007692	tetramer interface [polypeptide binding]; other site
65393007693	GAF domain; Region: GAF_3; pfam13492
65393007694	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
65393007695	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
65393007696	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
65393007697	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65393007698	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
65393007699	active site
65393007700	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
65393007701	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393007702	binding surface
65393007703	TPR motif; other site
65393007704	Tetratricopeptide repeat; Region: TPR_9; pfam13371
65393007705	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
65393007706	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
65393007707	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
65393007708	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
65393007709	TPR repeat; Region: TPR_11; pfam13414
65393007710	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393007711	binding surface
65393007712	TPR motif; other site
65393007713	TPR repeat; Region: TPR_11; pfam13414
65393007714	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393007715	binding surface
65393007716	TPR motif; other site
65393007717	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
65393007718	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
65393007719	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
65393007720	active site
65393007721	dimer interface [polypeptide binding]; other site
65393007722	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
65393007723	PHP domain; Region: PHP; pfam02811
65393007724	active site
65393007725	Transglycosylase; Region: Transgly; pfam00912
65393007726	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
65393007727	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
65393007728	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
65393007729	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
65393007730	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
65393007731	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
65393007732	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
65393007733	thiS-thiF/thiG interaction site; other site
65393007734	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
65393007735	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
65393007736	thiamine phosphate binding site [chemical binding]; other site
65393007737	active site
65393007738	pyrophosphate binding site [ion binding]; other site
65393007739	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
65393007740	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
65393007741	Uncharacterized conserved protein [Function unknown]; Region: COG3791
65393007742	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
65393007743	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
65393007744	active site
65393007745	Zn binding site [ion binding]; other site
65393007746	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65393007747	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
65393007748	trehalose synthase; Region: treS_nterm; TIGR02456
65393007749	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
65393007750	active site
65393007751	catalytic site [active]
65393007752	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
65393007753	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
65393007754	HEPN domain; Region: HEPN; cl00824
65393007755	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65393007756	active site
65393007757	NTP binding site [chemical binding]; other site
65393007758	metal binding triad [ion binding]; metal-binding site
65393007759	antibiotic binding site [chemical binding]; other site
65393007760	4-alpha-glucanotransferase; Provisional; Region: PRK14508
65393007761	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
65393007762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393007763	putative substrate translocation pore; other site
65393007764	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
65393007765	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
65393007766	aromatic arch; other site
65393007767	DCoH dimer interaction site [polypeptide binding]; other site
65393007768	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
65393007769	DCoH tetramer interaction site [polypeptide binding]; other site
65393007770	substrate binding site [chemical binding]; other site
65393007771	ENT domain; Region: ENT; pfam03735
65393007772	calmodulin; Provisional; Region: PTZ00184
65393007773	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
65393007774	Ca2+ binding site [ion binding]; other site
65393007775	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
65393007776	Ca2+ binding site [ion binding]; other site
65393007777	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
65393007778	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65393007779	catalytic triad [active]
65393007780	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
65393007781	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393007782	active site
65393007783	ATP binding site [chemical binding]; other site
65393007784	substrate binding site [chemical binding]; other site
65393007785	activation loop (A-loop); other site
65393007786	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
65393007787	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
65393007788	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
65393007789	sulfite reductase subunit beta; Provisional; Region: PRK13504
65393007790	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
65393007791	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
65393007792	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393007793	phosphopeptide binding site; other site
65393007794	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65393007795	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393007796	phosphopeptide binding site; other site
65393007797	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
65393007798	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
65393007799	Walker A/P-loop; other site
65393007800	ATP binding site [chemical binding]; other site
65393007801	Q-loop/lid; other site
65393007802	ABC transporter signature motif; other site
65393007803	Walker B; other site
65393007804	D-loop; other site
65393007805	H-loop/switch region; other site
65393007806	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
65393007807	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
65393007808	6-phosphofructokinase; Provisional; Region: PRK14071
65393007809	active site
65393007810	ADP/pyrophosphate binding site [chemical binding]; other site
65393007811	dimerization interface [polypeptide binding]; other site
65393007812	allosteric effector site; other site
65393007813	fructose-1,6-bisphosphate binding site; other site
65393007814	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
65393007815	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
65393007816	DNA binding residues [nucleotide binding]
65393007817	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
65393007818	catalytic residues [active]
65393007819	catalytic nucleophile [active]
65393007820	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393007821	Probable transposase; Region: OrfB_IS605; pfam01385
65393007822	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393007823	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393007824	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393007825	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393007826	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393007827	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
65393007828	MPT binding site; other site
65393007829	trimer interface [polypeptide binding]; other site
65393007830	photosystem II reaction center protein Psb28; Provisional; Region: PRK13612
65393007831	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
65393007832	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
65393007833	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
65393007834	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
65393007835	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65393007836	catalytic residue [active]
65393007837	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
65393007838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393007839	binding surface
65393007840	TPR motif; other site
65393007841	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393007842	binding surface
65393007843	TPR motif; other site
65393007844	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393007845	binding surface
65393007846	TPR motif; other site
65393007847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393007848	binding surface
65393007849	TPR motif; other site
65393007850	TPR repeat; Region: TPR_11; pfam13414
65393007851	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
65393007852	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393007853	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393007854	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393007855	Probable transposase; Region: OrfB_IS605; pfam01385
65393007856	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393007857	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
65393007858	ABC1 family; Region: ABC1; pfam03109
65393007859	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
65393007860	active site
65393007861	ATP binding site [chemical binding]; other site
65393007862	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
65393007863	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
65393007864	Substrate binding site; other site
65393007865	Transcriptional regulator [Transcription]; Region: LytR; COG1316
65393007866	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
65393007867	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393007868	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393007869	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393007870	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393007871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393007872	active site
65393007873	phosphorylation site [posttranslational modification]
65393007874	intermolecular recognition site; other site
65393007875	dimerization interface [polypeptide binding]; other site
65393007876	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393007877	DNA binding residues [nucleotide binding]
65393007878	dimerization interface [polypeptide binding]; other site
65393007879	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
65393007880	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
65393007881	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
65393007882	nucleotide binding site [chemical binding]; other site
65393007883	NEF interaction site [polypeptide binding]; other site
65393007884	SBD interface [polypeptide binding]; other site
65393007885	Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493
65393007886	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
65393007887	Protein of unknown function (DUF1626); Region: DUF1626; pfam07788
65393007888	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
65393007889	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
65393007890	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
65393007891	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
65393007892	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393007893	FeS/SAM binding site; other site
65393007894	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
65393007895	catalytic site [active]
65393007896	putative active site [active]
65393007897	putative substrate binding site [chemical binding]; other site
65393007898	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393007899	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393007900	Probable transposase; Region: OrfB_IS605; pfam01385
65393007901	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393007902	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
65393007903	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
65393007904	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
65393007905	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
65393007906	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
65393007907	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
65393007908	TrkA-N domain; Region: TrkA_N; pfam02254
65393007909	TrkA-C domain; Region: TrkA_C; pfam02080
65393007910	TrkA-C domain; Region: TrkA_C; pfam02080
65393007911	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
65393007912	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
65393007913	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
65393007914	metal binding site [ion binding]; metal-binding site
65393007915	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
65393007916	dimer interface [polypeptide binding]; other site
65393007917	FMN binding site [chemical binding]; other site
65393007918	fumarate hydratase; Reviewed; Region: fumC; PRK00485
65393007919	Class II fumarases; Region: Fumarase_classII; cd01362
65393007920	active site
65393007921	tetramer interface [polypeptide binding]; other site
65393007922	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
65393007923	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
65393007924	inhibitor-cofactor binding pocket; inhibition site
65393007925	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393007926	catalytic residue [active]
65393007927	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393007928	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393007929	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393007930	EamA-like transporter family; Region: EamA; pfam00892
65393007931	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
65393007932	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
65393007933	D1 interface; other site
65393007934	chlorophyll binding site; other site
65393007935	pheophytin binding site; other site
65393007936	beta carotene binding site; other site
65393007937	cytochrome b559 beta interface; other site
65393007938	quinone binding site; other site
65393007939	cytochrome b559 alpha interface; other site
65393007940	protein J interface; other site
65393007941	protein H interface; other site
65393007942	protein X interface; other site
65393007943	core light harvesting protein interface; other site
65393007944	protein L interface; other site
65393007945	CP43 interface; other site
65393007946	protein T interface; other site
65393007947	Fe binding site [ion binding]; other site
65393007948	protein M interface; other site
65393007949	Mn-stabilizing polypeptide interface; other site
65393007950	bromide binding site; other site
65393007951	cytochrome c-550 interface; other site
65393007952	hypothetical protein; Provisional; Region: PRK13683
65393007953	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65393007954	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
65393007955	Walker A/P-loop; other site
65393007956	ATP binding site [chemical binding]; other site
65393007957	Q-loop/lid; other site
65393007958	ABC transporter signature motif; other site
65393007959	Walker B; other site
65393007960	D-loop; other site
65393007961	H-loop/switch region; other site
65393007962	YacP-like NYN domain; Region: NYN_YacP; pfam05991
65393007963	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
65393007964	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
65393007965	[2Fe-2S] cluster binding site [ion binding]; other site
65393007966	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
65393007967	hydrophobic ligand binding site; other site
65393007968	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
65393007969	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
65393007970	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65393007971	catalytic residue [active]
65393007972	GH3 auxin-responsive promoter; Region: GH3; pfam03321
65393007973	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
65393007974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393007975	Major Facilitator Superfamily; Region: MFS_1; pfam07690
65393007976	putative substrate translocation pore; other site
65393007977	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
65393007978	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
65393007979	putative NADP binding site [chemical binding]; other site
65393007980	putative substrate binding site [chemical binding]; other site
65393007981	active site
65393007982	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
65393007983	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393007984	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393007985	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393007986	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393007987	Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459
65393007988	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
65393007989	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
65393007990	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
65393007991	active site
65393007992	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
65393007993	Uncharacterized conserved protein [Function unknown]; Region: COG3339
65393007994	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
65393007995	AsmA family; Region: AsmA; pfam05170
65393007996	Family of unknown function (DUF490); Region: DUF490; pfam04357
65393007997	cytochrome c biogenesis protein; Region: ccsA; CHL00045
65393007998	hypothetical protein; Reviewed; Region: PRK12275
65393007999	four helix bundle protein; Region: TIGR02436
65393008000	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
65393008001	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
65393008002	Ligand Binding Site [chemical binding]; other site
65393008003	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
65393008004	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
65393008005	Response regulator receiver domain; Region: Response_reg; pfam00072
65393008006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393008007	active site
65393008008	phosphorylation site [posttranslational modification]
65393008009	intermolecular recognition site; other site
65393008010	dimerization interface [polypeptide binding]; other site
65393008011	Response regulator receiver domain; Region: Response_reg; pfam00072
65393008012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393008013	active site
65393008014	phosphorylation site [posttranslational modification]
65393008015	intermolecular recognition site; other site
65393008016	dimerization interface [polypeptide binding]; other site
65393008017	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
65393008018	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65393008019	binding surface
65393008020	TPR motif; other site
65393008021	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393008022	dimerization interface [polypeptide binding]; other site
65393008023	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
65393008024	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
65393008025	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65393008026	dimer interface [polypeptide binding]; other site
65393008027	putative CheW interface [polypeptide binding]; other site
65393008028	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
65393008029	Permease; Region: Permease; cl00510
65393008030	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393008031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393008032	active site
65393008033	phosphorylation site [posttranslational modification]
65393008034	intermolecular recognition site; other site
65393008035	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
65393008036	tetramer interface [polypeptide binding]; other site
65393008037	dimer interface [polypeptide binding]; other site
65393008038	circadian clock protein KaiC; Reviewed; Region: PRK09302
65393008039	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
65393008040	Walker A motif; other site
65393008041	ATP binding site [chemical binding]; other site
65393008042	Walker B motif; other site
65393008043	recA bacterial DNA recombination protein; Region: RecA; cl17211
65393008044	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
65393008045	Walker A motif; other site
65393008046	ATP binding site [chemical binding]; other site
65393008047	Walker B motif; other site
65393008048	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
65393008049	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
65393008050	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
65393008051	substrate binding pocket [chemical binding]; other site
65393008052	membrane-bound complex binding site; other site
65393008053	hinge residues; other site
65393008054	Domain of unknown function DUF20; Region: UPF0118; pfam01594
65393008055	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
65393008056	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393008057	putative active site [active]
65393008058	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393008059	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65393008060	phosphopeptide binding site; other site
65393008061	Transglycosylase; Region: Transgly; pfam00912
65393008062	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
65393008063	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
65393008064	DNA methylase; Region: N6_N4_Mtase; cl17433
65393008065	Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194
65393008066	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
65393008067	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393008068	Coenzyme A binding pocket [chemical binding]; other site
65393008069	CAAX protease self-immunity; Region: Abi; pfam02517
65393008070	cell division topological specificity factor MinE; Provisional; Region: PRK13988
65393008071	septum site-determining protein MinD; Region: minD_bact; TIGR01968
65393008072	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
65393008073	Switch I; other site
65393008074	Switch II; other site
65393008075	septum formation inhibitor; Reviewed; Region: minC; PRK00513
65393008076	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
65393008077	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
65393008078	TIGR03790 family protein; Region: TIGR03790
65393008079	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
65393008080	methionine sulfoxide reductase B; Provisional; Region: PRK00222
65393008081	SelR domain; Region: SelR; pfam01641
65393008082	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
65393008083	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
65393008084	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
65393008085	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65393008086	TIGR04168 family protein; Region: TIGR04168
65393008087	Predicted integral membrane protein [Function unknown]; Region: COG0762
65393008088	Domain of unknown function DUF20; Region: UPF0118; pfam01594
65393008089	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
65393008090	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393008091	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393008092	metal binding site [ion binding]; metal-binding site
65393008093	active site
65393008094	I-site; other site
65393008095	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
65393008096	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
65393008097	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
65393008098	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
65393008099	ribonuclease PH; Reviewed; Region: rph; PRK00173
65393008100	Ribonuclease PH; Region: RNase_PH_bact; cd11362
65393008101	hexamer interface [polypeptide binding]; other site
65393008102	active site
65393008103	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
65393008104	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
65393008105	Walker A/P-loop; other site
65393008106	ATP binding site [chemical binding]; other site
65393008107	Q-loop/lid; other site
65393008108	ABC transporter signature motif; other site
65393008109	Walker B; other site
65393008110	D-loop; other site
65393008111	H-loop/switch region; other site
65393008112	mce related protein; Region: MCE; pfam02470
65393008113	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
65393008114	SdiA-regulated; Region: SdiA-regulated; cd09971
65393008115	putative active site [active]
65393008116	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393008117	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65393008118	TPR motif; other site
65393008119	binding surface
65393008120	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393008121	CVNH domain; Region: CVNH; pfam08881
65393008122	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
65393008123	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
65393008124	dimer interface [polypeptide binding]; other site
65393008125	anticodon binding site; other site
65393008126	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
65393008127	homodimer interface [polypeptide binding]; other site
65393008128	motif 1; other site
65393008129	active site
65393008130	motif 2; other site
65393008131	GAD domain; Region: GAD; pfam02938
65393008132	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
65393008133	active site
65393008134	motif 3; other site
65393008135	Uncharacterized conserved protein [Function unknown]; Region: COG1565
65393008136	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
65393008137	16S rRNA methyltransferase B; Provisional; Region: PRK14901
65393008138	putative RNA binding site [nucleotide binding]; other site
65393008139	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393008140	S-adenosylmethionine binding site [chemical binding]; other site
65393008141	tellurium resistance terB-like protein; Region: terB_like; cd07177
65393008142	metal binding site [ion binding]; metal-binding site
65393008143	intracellular protease, PfpI family; Region: PfpI; TIGR01382
65393008144	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
65393008145	conserved cys residue [active]
65393008146	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
65393008147	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
65393008148	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
65393008149	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
65393008150	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65393008151	active site
65393008152	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65393008153	DNA methylase; Region: N6_N4_Mtase; pfam01555
65393008154	Methyltransferase domain; Region: Methyltransf_26; pfam13659
65393008155	S-adenosylmethionine binding site [chemical binding]; other site
65393008156	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
65393008157	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
65393008158	Domain of unknown function DUF59; Region: DUF59; pfam01883
65393008159	antiporter inner membrane protein; Provisional; Region: PRK11670
65393008160	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
65393008161	Walker A motif; other site
65393008162	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
65393008163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393008164	binding surface
65393008165	TPR motif; other site
65393008166	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393008167	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
65393008168	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
65393008169	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
65393008170	CHASE2 domain; Region: CHASE2; pfam05226
65393008171	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
65393008172	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
65393008173	Uncharacterized conserved protein [Function unknown]; Region: COG5464
65393008174	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
65393008175	CHAT domain; Region: CHAT; cl17868
65393008176	NB-ARC domain; Region: NB-ARC; pfam00931
65393008177	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393008178	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393008179	binding surface
65393008180	TPR motif; other site
65393008181	Uncharacterized conserved protein [Function unknown]; Region: COG1262
65393008182	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
65393008183	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
65393008184	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
65393008185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393008186	Mg2+ binding site [ion binding]; other site
65393008187	G-X-G motif; other site
65393008188	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
65393008189	anchoring element; other site
65393008190	dimer interface [polypeptide binding]; other site
65393008191	ATP binding site [chemical binding]; other site
65393008192	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
65393008193	active site
65393008194	metal binding site [ion binding]; metal-binding site
65393008195	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
65393008196	protein-splicing catalytic site; other site
65393008197	thioester formation/cholesterol transfer; other site
65393008198	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65393008199	non-specific DNA binding site [nucleotide binding]; other site
65393008200	salt bridge; other site
65393008201	sequence-specific DNA binding site [nucleotide binding]; other site
65393008202	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
65393008203	active site
65393008204	metal binding site [ion binding]; metal-binding site
65393008205	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
65393008206	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
65393008207	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
65393008208	putative DNA binding site [nucleotide binding]; other site
65393008209	putative Zn2+ binding site [ion binding]; other site
65393008210	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
65393008211	metal-binding site [ion binding]
65393008212	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393008213	putative active site [active]
65393008214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
65393008215	HAS barrel domain; Region: HAS-barrel; pfam09378
65393008216	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
65393008217	TIR domain; Region: TIR_2; pfam13676
65393008218	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
65393008219	Uncharacterized conserved protein [Function unknown]; Region: COG2968
65393008220	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
65393008221	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
65393008222	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393008223	S-adenosylmethionine binding site [chemical binding]; other site
65393008224	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
65393008225	PLD-like domain; Region: PLDc_2; pfam13091
65393008226	putative active site [active]
65393008227	catalytic site [active]
65393008228	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
65393008229	PLD-like domain; Region: PLDc_2; pfam13091
65393008230	putative active site [active]
65393008231	catalytic site [active]
65393008232	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
65393008233	Resolvase, N terminal domain; Region: Resolvase; smart00857
65393008234	Recombinase; Region: Recombinase; pfam07508
65393008235	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
65393008236	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
65393008237	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65393008238	dimer interface [polypeptide binding]; other site
65393008239	putative metal binding site [ion binding]; other site
65393008240	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
65393008241	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
65393008242	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393008243	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393008244	metal binding site [ion binding]; metal-binding site
65393008245	active site
65393008246	I-site; other site
65393008247	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393008248	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393008249	metal binding site [ion binding]; metal-binding site
65393008250	active site
65393008251	I-site; other site
65393008252	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
65393008253	putative hexamer interface [polypeptide binding]; other site
65393008254	putative hexagonal pore; other site
65393008255	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
65393008256	Hexamer interface [polypeptide binding]; other site
65393008257	Hexagonal pore residue; other site
65393008258	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008259	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393008260	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008261	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008262	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393008263	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008264	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008265	ribosomal protein S18; Region: rps18; CHL00077
65393008266	ribosomal protein L33; Region: rpl33; CHL00104
65393008267	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
65393008268	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
65393008269	Predicted membrane protein [Function unknown]; Region: COG2324
65393008270	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
65393008271	active site
65393008272	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
65393008273	Helix-turn-helix domain; Region: HTH_28; pfam13518
65393008274	DDE superfamily endonuclease; Region: DDE_3; pfam13358
65393008275	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
65393008276	Hantavirus glycoprotein G2; Region: Hanta_G2; pfam01561
65393008277	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
65393008278	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
65393008279	conserved cys residue [active]
65393008280	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393008281	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393008282	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393008283	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393008284	DNA binding residues [nucleotide binding]
65393008285	dimerization interface [polypeptide binding]; other site
65393008286	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
65393008287	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
65393008288	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
65393008289	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393008290	motif I; other site
65393008291	motif II; other site
65393008292	cytochrome c-550; Provisional; Region: psbV; PRK13619
65393008293	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
65393008294	active site
65393008295	SAM binding site [chemical binding]; other site
65393008296	homodimer interface [polypeptide binding]; other site
65393008297	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
65393008298	putative active site [active]
65393008299	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
65393008300	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
65393008301	putative active site [active]
65393008302	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
65393008303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393008304	dimer interface [polypeptide binding]; other site
65393008305	conserved gate region; other site
65393008306	putative PBP binding loops; other site
65393008307	ABC-ATPase subunit interface; other site
65393008308	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
65393008309	iron-sulfur cluster [ion binding]; other site
65393008310	[2Fe-2S] cluster binding site [ion binding]; other site
65393008311	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
65393008312	Pheophorbide a oxygenase; Region: PaO; pfam08417
65393008313	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
65393008314	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
65393008315	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
65393008316	Walker A/P-loop; other site
65393008317	ATP binding site [chemical binding]; other site
65393008318	Q-loop/lid; other site
65393008319	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
65393008320	ABC transporter signature motif; other site
65393008321	Walker B; other site
65393008322	D-loop; other site
65393008323	H-loop/switch region; other site
65393008324	nucleotide binding region [chemical binding]; other site
65393008325	helicase superfamily c-terminal domain; Region: HELICc; smart00490
65393008326	ATP-binding site [chemical binding]; other site
65393008327	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393008328	primosomal protein N' Region: priA; TIGR00595
65393008329	ATP binding site [chemical binding]; other site
65393008330	putative Mg++ binding site [ion binding]; other site
65393008331	helicase superfamily c-terminal domain; Region: HELICc; smart00490
65393008332	ATP-binding site [chemical binding]; other site
65393008333	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
65393008334	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
65393008335	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393008336	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65393008337	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393008338	DNA binding residues [nucleotide binding]
65393008339	AMIN domain; Region: AMIN; pfam11741
65393008340	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
65393008341	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
65393008342	active site
65393008343	metal binding site [ion binding]; metal-binding site
65393008344	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393008345	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65393008346	phosphopeptide binding site; other site
65393008347	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393008348	metal binding site [ion binding]; metal-binding site
65393008349	active site
65393008350	I-site; other site
65393008351	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393008352	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65393008353	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393008354	phosphopeptide binding site; other site
65393008355	PAS domain S-box; Region: sensory_box; TIGR00229
65393008356	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393008357	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393008358	metal binding site [ion binding]; metal-binding site
65393008359	active site
65393008360	I-site; other site
65393008361	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393008362	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65393008363	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393008364	phosphopeptide binding site; other site
65393008365	PAS domain S-box; Region: sensory_box; TIGR00229
65393008366	PAS domain; Region: PAS_8; pfam13188
65393008367	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393008368	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393008369	metal binding site [ion binding]; metal-binding site
65393008370	active site
65393008371	I-site; other site
65393008372	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393008373	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393008374	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393008375	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65393008376	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65393008377	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65393008378	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
65393008379	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
65393008380	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
65393008381	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
65393008382	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393008383	Walker A motif; other site
65393008384	ATP binding site [chemical binding]; other site
65393008385	Walker B motif; other site
65393008386	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
65393008387	Clp protease; Region: CLP_protease; pfam00574
65393008388	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
65393008389	oligomer interface [polypeptide binding]; other site
65393008390	active site residues [active]
65393008391	trigger factor; Provisional; Region: tig; PRK01490
65393008392	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
65393008393	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
65393008394	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
65393008395	diiron binding motif [ion binding]; other site
65393008396	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
65393008397	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
65393008398	Walker A/P-loop; other site
65393008399	ATP binding site [chemical binding]; other site
65393008400	Q-loop/lid; other site
65393008401	ABC transporter signature motif; other site
65393008402	Walker B; other site
65393008403	D-loop; other site
65393008404	H-loop/switch region; other site
65393008405	Ferredoxin [Energy production and conversion]; Region: COG1146
65393008406	Predicted membrane protein [Function unknown]; Region: COG4244
65393008407	Predicted membrane protein [Function unknown]; Region: COG4244
65393008408	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
65393008409	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
65393008410	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
65393008411	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
65393008412	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
65393008413	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
65393008414	Subunit I/III interface [polypeptide binding]; other site
65393008415	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
65393008416	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
65393008417	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393008418	Probable transposase; Region: OrfB_IS605; pfam01385
65393008419	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393008420	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
65393008421	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
65393008422	active site
65393008423	homodimer interface [polypeptide binding]; other site
65393008424	catalytic site [active]
65393008425	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
65393008426	intracellular protease, PfpI family; Region: PfpI; TIGR01382
65393008427	proposed catalytic triad [active]
65393008428	conserved cys residue [active]
65393008429	Ferritin-like domain; Region: Ferritin; pfam00210
65393008430	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
65393008431	dinuclear metal binding motif [ion binding]; other site
65393008432	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
65393008433	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
65393008434	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393008435	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65393008436	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393008437	DNA binding residues [nucleotide binding]
65393008438	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393008439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393008440	active site
65393008441	phosphorylation site [posttranslational modification]
65393008442	intermolecular recognition site; other site
65393008443	dimerization interface [polypeptide binding]; other site
65393008444	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
65393008445	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
65393008446	BON domain; Region: BON; cl02771
65393008447	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
65393008448	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
65393008449	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393008450	ATP binding site [chemical binding]; other site
65393008451	Mg2+ binding site [ion binding]; other site
65393008452	G-X-G motif; other site
65393008453	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
65393008454	ATP binding site [chemical binding]; other site
65393008455	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
65393008456	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65393008457	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
65393008458	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
65393008459	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
65393008460	B12 binding site [chemical binding]; other site
65393008461	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
65393008462	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
65393008463	FeS/SAM binding site; other site
65393008464	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
65393008465	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
65393008466	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
65393008467	metal-binding site [ion binding]
65393008468	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65393008469	Soluble P-type ATPase [General function prediction only]; Region: COG4087
65393008470	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65393008471	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393008472	phosphopeptide binding site; other site
65393008473	DNA polymerase III subunit delta'; Validated; Region: PRK07399
65393008474	DNA polymerase III subunit delta'; Validated; Region: PRK08485
65393008475	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393008476	Radical SAM superfamily; Region: Radical_SAM; pfam04055
65393008477	FeS/SAM binding site; other site
65393008478	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
65393008479	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
65393008480	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
65393008481	transmembrane helices; other site
65393008482	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
65393008483	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
65393008484	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
65393008485	Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187
65393008486	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
65393008487	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
65393008488	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
65393008489	dephospho-CoA kinase; Region: TIGR00152
65393008490	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
65393008491	CoA-binding site [chemical binding]; other site
65393008492	ATP-binding [chemical binding]; other site
65393008493	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
65393008494	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
65393008495	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
65393008496	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393008497	AAA-like domain; Region: AAA_10; pfam12846
65393008498	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
65393008499	active site
65393008500	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393008501	Calx-beta domain; Region: Calx-beta; pfam03160
65393008502	Calx-beta domain; Region: Calx-beta; pfam03160
65393008503	FAD binding domain; Region: FAD_binding_4; pfam01565
65393008504	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
65393008505	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
65393008506	G1 box; other site
65393008507	GTP/Mg2+ binding site [chemical binding]; other site
65393008508	G2 box; other site
65393008509	Switch I region; other site
65393008510	G3 box; other site
65393008511	Switch II region; other site
65393008512	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
65393008513	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
65393008514	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
65393008515	P-loop, Walker A motif; other site
65393008516	Base recognition motif; other site
65393008517	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
65393008518	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393008519	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
65393008520	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393008521	structural tetrad; other site
65393008522	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
65393008523	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
65393008524	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65393008525	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
65393008526	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
65393008527	Soluble P-type ATPase [General function prediction only]; Region: COG4087
65393008528	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
65393008529	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
65393008530	dimerization interface [polypeptide binding]; other site
65393008531	active site
65393008532	metal binding site [ion binding]; metal-binding site
65393008533	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
65393008534	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
65393008535	anti sigma factor interaction site; other site
65393008536	regulatory phosphorylation site [posttranslational modification]; other site
65393008537	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
65393008538	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
65393008539	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
65393008540	catalytic site [active]
65393008541	subunit interface [polypeptide binding]; other site
65393008542	Transposase; Region: HTH_Tnp_1; cl17663
65393008543	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008544	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65393008545	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008546	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008547	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008548	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008549	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008550	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008551	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008552	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
65393008553	acetyl-CoA synthetase; Provisional; Region: PRK00174
65393008554	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
65393008555	active site
65393008556	CoA binding site [chemical binding]; other site
65393008557	acyl-activating enzyme (AAE) consensus motif; other site
65393008558	AMP binding site [chemical binding]; other site
65393008559	acetate binding site [chemical binding]; other site
65393008560	antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819
65393008561	toxin interface [polypeptide binding]; other site
65393008562	Zn binding site [ion binding]; other site
65393008563	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
65393008564	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
65393008565	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
65393008566	putative active site [active]
65393008567	Restriction endonuclease; Region: Mrr_cat; pfam04471
65393008568	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
65393008569	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
65393008570	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
65393008571	substrate binding site [chemical binding]; other site
65393008572	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
65393008573	substrate binding site [chemical binding]; other site
65393008574	ligand binding site [chemical binding]; other site
65393008575	YcfA-like protein; Region: YcfA; pfam07927
65393008576	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
65393008577	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393008578	antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819
65393008579	Zn binding site [ion binding]; other site
65393008580	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
65393008581	inhibitor binding site; inhibition site
65393008582	catalytic motif [active]
65393008583	Catalytic residue [active]
65393008584	Active site flap [active]
65393008585	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393008586	putative active site [active]
65393008587	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
65393008588	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393008589	active site
65393008590	motif I; other site
65393008591	motif II; other site
65393008592	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393008593	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
65393008594	cobalamin synthase; Reviewed; Region: cobS; PRK00235
65393008595	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
65393008596	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
65393008597	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393008598	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
65393008599	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
65393008600	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
65393008601	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
65393008602	substrate binding pocket [chemical binding]; other site
65393008603	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
65393008604	B12 binding site [chemical binding]; other site
65393008605	cobalt ligand [ion binding]; other site
65393008606	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
65393008607	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393008608	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393008609	Probable transposase; Region: OrfB_IS605; pfam01385
65393008610	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
65393008611	Amidinotransferase; Region: Amidinotransf; cl12043
65393008612	Uncharacterized conserved protein [Function unknown]; Region: COG1915
65393008613	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
65393008614	homodimer interface [polypeptide binding]; other site
65393008615	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
65393008616	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
65393008617	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393008618	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393008619	metal binding site [ion binding]; metal-binding site
65393008620	active site
65393008621	I-site; other site
65393008622	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
65393008623	arginine-tRNA ligase; Region: PLN02286
65393008624	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
65393008625	active site
65393008626	HIGH motif; other site
65393008627	KMSK motif region; other site
65393008628	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
65393008629	tRNA binding surface [nucleotide binding]; other site
65393008630	anticodon binding site; other site
65393008631	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65393008632	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
65393008633	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65393008634	Predicted permeases [General function prediction only]; Region: COG0679
65393008635	aspartate kinase; Provisional; Region: PRK07431
65393008636	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
65393008637	putative catalytic residues [active]
65393008638	putative nucleotide binding site [chemical binding]; other site
65393008639	putative aspartate binding site [chemical binding]; other site
65393008640	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
65393008641	putative allosteric regulatory site; other site
65393008642	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
65393008643	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
65393008644	putative allosteric regulatory site; other site
65393008645	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
65393008646	putative allosteric regulatory residue; other site
65393008647	TIR domain; Region: TIR_2; pfam13676
65393008648	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393008649	structural tetrad; other site
65393008650	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393008651	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393008652	structural tetrad; other site
65393008653	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393008654	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
65393008655	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
65393008656	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
65393008657	TPP-binding site [chemical binding]; other site
65393008658	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
65393008659	Transposase IS200 like; Region: Y1_Tnp; pfam01797
65393008660	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
65393008661	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
65393008662	NADP-binding site; other site
65393008663	homotetramer interface [polypeptide binding]; other site
65393008664	substrate binding site [chemical binding]; other site
65393008665	homodimer interface [polypeptide binding]; other site
65393008666	active site
65393008667	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65393008668	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
65393008669	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
65393008670	Leucine-rich repeats; other site
65393008671	Substrate binding site [chemical binding]; other site
65393008672	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
65393008673	Leucine rich repeat; Region: LRR_8; pfam13855
65393008674	Leucine rich repeat; Region: LRR_8; pfam13855
65393008675	Leucine rich repeat; Region: LRR_8; pfam13855
65393008676	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
65393008677	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
65393008678	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
65393008679	G1 box; other site
65393008680	GTP/Mg2+ binding site [chemical binding]; other site
65393008681	G2 box; other site
65393008682	Switch I region; other site
65393008683	G3 box; other site
65393008684	Switch II region; other site
65393008685	G4 box; other site
65393008686	G5 box; other site
65393008687	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
65393008688	putative lipid kinase; Reviewed; Region: PRK13057
65393008689	CHAT domain; Region: CHAT; cl17868
65393008690	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393008691	phosphopeptide binding site; other site
65393008692	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393008693	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393008694	DNA binding residues [nucleotide binding]
65393008695	AAA ATPase domain; Region: AAA_16; pfam13191
65393008696	NACHT domain; Region: NACHT; pfam05729
65393008697	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
65393008698	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
65393008699	putative ADP-binding pocket [chemical binding]; other site
65393008700	anthranilate synthase component I-like protein; Validated; Region: PRK05940
65393008701	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
65393008702	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
65393008703	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
65393008704	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
65393008705	homopentamer interface [polypeptide binding]; other site
65393008706	active site
65393008707	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
65393008708	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
65393008709	putative catalytic cysteine [active]
65393008710	Bacterial SH3 domain; Region: SH3_3; pfam08239
65393008711	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
65393008712	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
65393008713	active site
65393008714	metal binding site [ion binding]; metal-binding site
65393008715	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
65393008716	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
65393008717	Walker A/P-loop; other site
65393008718	ATP binding site [chemical binding]; other site
65393008719	Q-loop/lid; other site
65393008720	ABC transporter signature motif; other site
65393008721	Walker B; other site
65393008722	D-loop; other site
65393008723	H-loop/switch region; other site
65393008724	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
65393008725	ABC1 family; Region: ABC1; cl17513
65393008726	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
65393008727	dimer interface [polypeptide binding]; other site
65393008728	substrate binding site [chemical binding]; other site
65393008729	metal binding sites [ion binding]; metal-binding site
65393008730	microcin C ABC transporter permease; Provisional; Region: PRK15021
65393008731	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
65393008732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393008733	dimer interface [polypeptide binding]; other site
65393008734	conserved gate region; other site
65393008735	putative PBP binding loops; other site
65393008736	ABC-ATPase subunit interface; other site
65393008737	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65393008738	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65393008739	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
65393008740	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
65393008741	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
65393008742	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
65393008743	nucleotide binding site [chemical binding]; other site
65393008744	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
65393008745	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
65393008746	putative NADP binding site [chemical binding]; other site
65393008747	putative substrate binding site [chemical binding]; other site
65393008748	active site
65393008749	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
65393008750	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65393008751	putative active site [active]
65393008752	putative metal binding site [ion binding]; other site
65393008753	Transposase IS200 like; Region: Y1_Tnp; cl00848
65393008754	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
65393008755	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
65393008756	P loop; other site
65393008757	Nucleotide binding site [chemical binding]; other site
65393008758	DTAP/Switch II; other site
65393008759	Switch I; other site
65393008760	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
65393008761	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
65393008762	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
65393008763	substrate binding pocket [chemical binding]; other site
65393008764	membrane-bound complex binding site; other site
65393008765	hinge residues; other site
65393008766	rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260
65393008767	rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260
65393008768	radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261
65393008769	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393008770	FeS/SAM binding site; other site
65393008771	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
65393008772	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
65393008773	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
65393008774	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
65393008775	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393008776	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393008777	active site
65393008778	ATP binding site [chemical binding]; other site
65393008779	substrate binding site [chemical binding]; other site
65393008780	activation loop (A-loop); other site
65393008781	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
65393008782	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393008783	Walker A motif; other site
65393008784	ATP binding site [chemical binding]; other site
65393008785	Walker B motif; other site
65393008786	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65393008787	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
65393008788	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
65393008789	dimanganese center [ion binding]; other site
65393008790	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
65393008791	dimer interface [polypeptide binding]; other site
65393008792	RNA polymerase sigma factor; Provisional; Region: PRK12518
65393008793	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393008794	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393008795	DNA binding residues [nucleotide binding]
65393008796	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
65393008797	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
65393008798	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
65393008799	DGQHR domain; Region: DGQHR; TIGR03187
65393008800	DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172
65393008801	glutathione synthetase; Provisional; Region: PRK05246
65393008802	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
65393008803	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
65393008804	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
65393008805	GSH binding site [chemical binding]; other site
65393008806	catalytic residues [active]
65393008807	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
65393008808	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
65393008809	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
65393008810	TRAM domain; Region: TRAM; pfam01938
65393008811	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
65393008812	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393008813	S-adenosylmethionine binding site [chemical binding]; other site
65393008814	RRXRR protein; Region: RRXRR; pfam14239
65393008815	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65393008816	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65393008817	active site
65393008818	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
65393008819	DNA protecting protein DprA; Region: dprA; TIGR00732
65393008820	Transcriptional regulator [Transcription]; Region: LysR; COG0583
65393008821	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
65393008822	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
65393008823	putative dimerization interface [polypeptide binding]; other site
65393008824	cell division protein; Validated; Region: ftsH; CHL00176
65393008825	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393008826	Walker A motif; other site
65393008827	ATP binding site [chemical binding]; other site
65393008828	Walker B motif; other site
65393008829	arginine finger; other site
65393008830	Peptidase family M41; Region: Peptidase_M41; pfam01434
65393008831	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
65393008832	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
65393008833	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65393008834	Magnesium ion binding site [ion binding]; other site
65393008835	Membrane protein of unknown function; Region: DUF360; pfam04020
65393008836	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
65393008837	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
65393008838	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
65393008839	Chromate transporter; Region: Chromate_transp; pfam02417
65393008840	Protein of unknown function DUF89; Region: DUF89; pfam01937
65393008841	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
65393008842	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
65393008843	Active site cavity [active]
65393008844	catalytic acid [active]
65393008845	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65393008846	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008847	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008848	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008849	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008850	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008851	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393008852	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393008853	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
65393008854	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393008855	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393008856	Probable transposase; Region: OrfB_IS605; pfam01385
65393008857	Cupin domain; Region: Cupin_2; cl17218
65393008858	YGGT family; Region: YGGT; pfam02325
65393008859	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
65393008860	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393008861	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
65393008862	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
65393008863	Low molecular weight phosphatase family; Region: LMWPc; cd00115
65393008864	active site
65393008865	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
65393008866	arsenical-resistance protein; Region: acr3; TIGR00832
65393008867	PBP superfamily domain; Region: PBP_like_2; cl17296
65393008868	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
65393008869	dimerization interface [polypeptide binding]; other site
65393008870	putative DNA binding site [nucleotide binding]; other site
65393008871	putative Zn2+ binding site [ion binding]; other site
65393008872	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
65393008873	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
65393008874	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
65393008875	putative active site [active]
65393008876	putative NTP binding site [chemical binding]; other site
65393008877	putative nucleic acid binding site [nucleotide binding]; other site
65393008878	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
65393008879	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65393008880	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65393008881	active site
65393008882	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
65393008883	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65393008884	catalytic residues [active]
65393008885	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
65393008886	4Fe-4S binding domain; Region: Fer4; pfam00037
65393008887	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
65393008888	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393008889	Protein of unknown function, DUF488; Region: DUF488; pfam04343
65393008890	lipoyl synthase; Provisional; Region: PRK05481
65393008891	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
65393008892	FeS/SAM binding site; other site
65393008893	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
65393008894	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
65393008895	Aluminium resistance protein; Region: Alum_res; pfam06838
65393008896	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
65393008897	Fatty acid desaturase; Region: FA_desaturase; pfam00487
65393008898	Di-iron ligands [ion binding]; other site
65393008899	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
65393008900	homodecamer interface [polypeptide binding]; other site
65393008901	GTP cyclohydrolase I; Provisional; Region: PLN03044
65393008902	active site
65393008903	putative catalytic site residues [active]
65393008904	zinc binding site [ion binding]; other site
65393008905	GTP-CH-I/GFRP interaction surface; other site
65393008906	short chain dehydrogenase; Provisional; Region: PRK07454
65393008907	classical (c) SDRs; Region: SDR_c; cd05233
65393008908	NAD(P) binding site [chemical binding]; other site
65393008909	active site
65393008910	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
65393008911	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393008912	Coenzyme A binding pocket [chemical binding]; other site
65393008913	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
65393008914	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
65393008915	DRTGG domain; Region: DRTGG; pfam07085
65393008916	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
65393008917	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65393008918	Soluble P-type ATPase [General function prediction only]; Region: COG4087
65393008919	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393008920	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393008921	structural tetrad; other site
65393008922	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
65393008923	PRC-barrel domain; Region: PRC; pfam05239
65393008924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
65393008925	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
65393008926	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
65393008927	molybdopterin cofactor binding site; other site
65393008928	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
65393008929	molybdopterin cofactor binding site; other site
65393008930	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
65393008931	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393008932	FeS/SAM binding site; other site
65393008933	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
65393008934	Uncharacterized conserved protein [Function unknown]; Region: COG5464
65393008935	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
65393008936	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
65393008937	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393008938	putative active site [active]
65393008939	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
65393008940	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
65393008941	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
65393008942	aromatic arch; other site
65393008943	DCoH dimer interaction site [polypeptide binding]; other site
65393008944	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
65393008945	DCoH tetramer interaction site [polypeptide binding]; other site
65393008946	substrate binding site [chemical binding]; other site
65393008947	Repair protein; Region: Repair_PSII; pfam04536
65393008948	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
65393008949	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
65393008950	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
65393008951	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
65393008952	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
65393008953	short chain dehydrogenase; Provisional; Region: PRK12367
65393008954	hypothetical protein; Validated; Region: PRK07411
65393008955	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
65393008956	ATP binding site [chemical binding]; other site
65393008957	substrate interface [chemical binding]; other site
65393008958	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
65393008959	active site residue [active]
65393008960	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
65393008961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393008962	putative substrate translocation pore; other site
65393008963	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
65393008964	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
65393008965	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65393008966	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
65393008967	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393008968	motif II; other site
65393008969	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
65393008970	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
65393008971	rod shape-determining protein MreC; Provisional; Region: PRK13922
65393008972	rod shape-determining protein MreC; Region: MreC; pfam04085
65393008973	rod shape-determining protein MreB; Provisional; Region: PRK13927
65393008974	MreB and similar proteins; Region: MreB_like; cd10225
65393008975	nucleotide binding site [chemical binding]; other site
65393008976	Mg binding site [ion binding]; other site
65393008977	putative protofilament interaction site [polypeptide binding]; other site
65393008978	RodZ interaction site [polypeptide binding]; other site
65393008979	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
65393008980	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
65393008981	dimer interface [polypeptide binding]; other site
65393008982	ssDNA binding site [nucleotide binding]; other site
65393008983	tetramer (dimer of dimers) interface [polypeptide binding]; other site
65393008984	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393008985	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
65393008986	putative ADP-binding pocket [chemical binding]; other site
65393008987	Bacterial sugar transferase; Region: Bac_transf; pfam02397
65393008988	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
65393008989	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
65393008990	NADP-binding site; other site
65393008991	homotetramer interface [polypeptide binding]; other site
65393008992	substrate binding site [chemical binding]; other site
65393008993	homodimer interface [polypeptide binding]; other site
65393008994	active site
65393008995	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
65393008996	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
65393008997	NADP binding site [chemical binding]; other site
65393008998	active site
65393008999	putative substrate binding site [chemical binding]; other site
65393009000	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
65393009001	HflK protein; Region: hflK; TIGR01933
65393009002	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
65393009003	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
65393009004	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
65393009005	Ion channel; Region: Ion_trans_2; pfam07885
65393009006	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
65393009007	membrane-bound complex binding site; other site
65393009008	hinge residues; other site
65393009009	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393009010	putative active site [active]
65393009011	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
65393009012	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
65393009013	active site
65393009014	PHP Thumb interface [polypeptide binding]; other site
65393009015	metal binding site [ion binding]; metal-binding site
65393009016	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
65393009017	protein-splicing catalytic site; other site
65393009018	thioester formation/cholesterol transfer; other site
65393009019	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
65393009020	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
65393009021	substrate binding pocket [chemical binding]; other site
65393009022	membrane-bound complex binding site; other site
65393009023	hinge residues; other site
65393009024	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
65393009025	Antitoxin ParD; Region: ParD; pfam09386
65393009026	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393009027	putative active site [active]
65393009028	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65393009029	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65393009030	catalytic loop [active]
65393009031	iron binding site [ion binding]; other site
65393009032	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
65393009033	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
65393009034	active site
65393009035	catalytic residues [active]
65393009036	metal binding site [ion binding]; metal-binding site
65393009037	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
65393009038	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65393009039	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393009040	S-adenosylmethionine binding site [chemical binding]; other site
65393009041	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393009042	putative active site [active]
65393009043	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393009044	putative active site [active]
65393009045	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
65393009046	Protein of unknown function DUF58; Region: DUF58; pfam01882
65393009047	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
65393009048	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
65393009049	putative acyl-acceptor binding pocket; other site
65393009050	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
65393009051	Predicted esterase [General function prediction only]; Region: COG0400
65393009052	putative hydrolase; Provisional; Region: PRK11460
65393009053	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
65393009054	Exoribonuclease R [Transcription]; Region: VacB; COG0557
65393009055	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
65393009056	RNB domain; Region: RNB; pfam00773
65393009057	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
65393009058	RNA binding site [nucleotide binding]; other site
65393009059	Clp protease; Region: CLP_protease; pfam00574
65393009060	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
65393009061	oligomer interface [polypeptide binding]; other site
65393009062	active site residues [active]
65393009063	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
65393009064	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
65393009065	cobalamin binding residues [chemical binding]; other site
65393009066	putative BtuC binding residues; other site
65393009067	dimer interface [polypeptide binding]; other site
65393009068	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
65393009069	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
65393009070	catalytic site [active]
65393009071	G-X2-G-X-G-K; other site
65393009072	hypothetical protein; Provisional; Region: PRK04323
65393009073	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
65393009074	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393009075	S-adenosylmethionine binding site [chemical binding]; other site
65393009076	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
65393009077	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
65393009078	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65393009079	catalytic residue [active]
65393009080	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
65393009081	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393009082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393009083	active site
65393009084	phosphorylation site [posttranslational modification]
65393009085	intermolecular recognition site; other site
65393009086	dimerization interface [polypeptide binding]; other site
65393009087	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393009088	DNA binding site [nucleotide binding]
65393009089	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
65393009090	phosphatidate cytidylyltransferase; Region: PLN02953
65393009091	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
65393009092	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
65393009093	putative active site [active]
65393009094	catalytic triad [active]
65393009095	putative dimer interface [polypeptide binding]; other site
65393009096	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
65393009097	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
65393009098	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
65393009099	active site
65393009100	interdomain interaction site; other site
65393009101	putative metal-binding site [ion binding]; other site
65393009102	nucleotide binding site [chemical binding]; other site
65393009103	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
65393009104	domain I; other site
65393009105	phosphate binding site [ion binding]; other site
65393009106	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
65393009107	domain II; other site
65393009108	domain III; other site
65393009109	nucleotide binding site [chemical binding]; other site
65393009110	DNA binding groove [nucleotide binding]
65393009111	catalytic site [active]
65393009112	domain IV; other site
65393009113	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
65393009114	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
65393009115	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
65393009116	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
65393009117	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
65393009118	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
65393009119	active site
65393009120	homodimer interface [polypeptide binding]; other site
65393009121	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
65393009122	classical (c) SDRs; Region: SDR_c; cd05233
65393009123	NAD(P) binding site [chemical binding]; other site
65393009124	active site
65393009125	pyruvate kinase; Provisional; Region: PRK06354
65393009126	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
65393009127	domain interfaces; other site
65393009128	active site
65393009129	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
65393009130	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
65393009131	Domain of unknown function DUF20; Region: UPF0118; pfam01594
65393009132	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
65393009133	iron-sulfur cluster [ion binding]; other site
65393009134	[2Fe-2S] cluster binding site [ion binding]; other site
65393009135	chaperone protein DnaJ; Provisional; Region: PRK14299
65393009136	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
65393009137	HSP70 interaction site [polypeptide binding]; other site
65393009138	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
65393009139	substrate binding site [polypeptide binding]; other site
65393009140	dimer interface [polypeptide binding]; other site
65393009141	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009142	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009143	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393009144	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009145	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
65393009146	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
65393009147	FMN binding site [chemical binding]; other site
65393009148	active site
65393009149	catalytic residues [active]
65393009150	substrate binding site [chemical binding]; other site
65393009151	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
65393009152	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
65393009153	Walker A/P-loop; other site
65393009154	ATP binding site [chemical binding]; other site
65393009155	Q-loop/lid; other site
65393009156	ABC transporter signature motif; other site
65393009157	Walker B; other site
65393009158	D-loop; other site
65393009159	H-loop/switch region; other site
65393009160	sulfate transport protein; Provisional; Region: cysT; CHL00187
65393009161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393009162	dimer interface [polypeptide binding]; other site
65393009163	conserved gate region; other site
65393009164	putative PBP binding loops; other site
65393009165	ABC-ATPase subunit interface; other site
65393009166	sulfate transport protein; Provisional; Region: cysT; CHL00187
65393009167	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393009168	dimer interface [polypeptide binding]; other site
65393009169	conserved gate region; other site
65393009170	putative PBP binding loops; other site
65393009171	ABC-ATPase subunit interface; other site
65393009172	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
65393009173	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
65393009174	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
65393009175	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393009176	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
65393009177	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393009178	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009179	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009180	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393009181	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009182	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
65393009183	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393009184	FeS/SAM binding site; other site
65393009185	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
65393009186	DNA polymerase III subunit delta; Validated; Region: PRK07452
65393009187	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
65393009188	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
65393009189	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
65393009190	CHRD domain; Region: CHRD; pfam07452
65393009191	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
65393009192	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
65393009193	[4Fe-4S] binding site [ion binding]; other site
65393009194	molybdopterin cofactor binding site; other site
65393009195	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
65393009196	molybdopterin cofactor binding site; other site
65393009197	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
65393009198	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
65393009199	ribosomal protein L21; Region: rpl21; CHL00075
65393009200	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
65393009201	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
65393009202	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
65393009203	nudix motif; other site
65393009204	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
65393009205	Dehydroquinase class II; Region: DHquinase_II; pfam01220
65393009206	trimer interface [polypeptide binding]; other site
65393009207	active site
65393009208	dimer interface [polypeptide binding]; other site
65393009209	competence damage-inducible protein A; Provisional; Region: PRK00549
65393009210	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
65393009211	putative MPT binding site; other site
65393009212	Competence-damaged protein; Region: CinA; pfam02464
65393009213	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
65393009214	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
65393009215	Mg++ binding site [ion binding]; other site
65393009216	putative catalytic motif [active]
65393009217	substrate binding site [chemical binding]; other site
65393009218	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
65393009219	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
65393009220	Probable Catalytic site; other site
65393009221	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
65393009222	Protein phosphatase 2C; Region: PP2C; pfam00481
65393009223	active site
65393009224	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
65393009225	S-adenosylmethionine synthetase; Validated; Region: PRK05250
65393009226	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
65393009227	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
65393009228	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
65393009229	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
65393009230	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393009231	motif II; other site
65393009232	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
65393009233	Caspase domain; Region: Peptidase_C14; pfam00656
65393009234	GUN4-like; Region: GUN4; pfam05419
65393009235	Uncharacterized conserved protein [Function unknown]; Region: COG2361
65393009236	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65393009237	active site
65393009238	NTP binding site [chemical binding]; other site
65393009239	metal binding triad [ion binding]; metal-binding site
65393009240	antibiotic binding site [chemical binding]; other site
65393009241	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
65393009242	30S ribosomal protein S1; Reviewed; Region: PRK07400
65393009243	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
65393009244	RNA binding site [nucleotide binding]; other site
65393009245	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
65393009246	RNA binding site [nucleotide binding]; other site
65393009247	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
65393009248	RNA binding site [nucleotide binding]; other site
65393009249	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
65393009250	ATP cone domain; Region: ATP-cone; pfam03477
65393009251	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
65393009252	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
65393009253	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
65393009254	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
65393009255	trimer interface [polypeptide binding]; other site
65393009256	active site
65393009257	UDP-GlcNAc binding site [chemical binding]; other site
65393009258	lipid binding site [chemical binding]; lipid-binding site
65393009259	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393009260	putative active site [active]
65393009261	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
65393009262	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
65393009263	Outer membrane efflux protein; Region: OEP; pfam02321
65393009264	Outer membrane efflux protein; Region: OEP; pfam02321
65393009265	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65393009266	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65393009267	catalytic loop [active]
65393009268	iron binding site [ion binding]; other site
65393009269	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
65393009270	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393009271	Ligand Binding Site [chemical binding]; other site
65393009272	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393009273	Ligand Binding Site [chemical binding]; other site
65393009274	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65393009275	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393009276	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
65393009277	Walker A/P-loop; other site
65393009278	ATP binding site [chemical binding]; other site
65393009279	Q-loop/lid; other site
65393009280	ABC transporter signature motif; other site
65393009281	Walker B; other site
65393009282	D-loop; other site
65393009283	H-loop/switch region; other site
65393009284	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
65393009285	conserved hypothetical protein; Region: TIGR03492
65393009286	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
65393009287	propionate/acetate kinase; Provisional; Region: PRK12379
65393009288	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
65393009289	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
65393009290	active site
65393009291	homodimer interface [polypeptide binding]; other site
65393009292	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
65393009293	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65393009294	CpeS-like protein; Region: CpeS; pfam09367
65393009295	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
65393009296	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
65393009297	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
65393009298	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
65393009299	HlyD family secretion protein; Region: HlyD_3; pfam13437
65393009300	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393009301	ligand binding site [chemical binding]; other site
65393009302	flexible hinge region; other site
65393009303	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
65393009304	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
65393009305	putative active site [active]
65393009306	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393009307	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
65393009308	Walker A/P-loop; other site
65393009309	ATP binding site [chemical binding]; other site
65393009310	Q-loop/lid; other site
65393009311	ABC transporter signature motif; other site
65393009312	Walker B; other site
65393009313	D-loop; other site
65393009314	H-loop/switch region; other site
65393009315	flavoprotein, HI0933 family; Region: TIGR00275
65393009316	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
65393009317	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65393009318	TPR motif; other site
65393009319	binding surface
65393009320	PAS fold; Region: PAS; pfam00989
65393009321	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393009322	putative active site [active]
65393009323	heme pocket [chemical binding]; other site
65393009324	PAS domain S-box; Region: sensory_box; TIGR00229
65393009325	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393009326	putative active site [active]
65393009327	heme pocket [chemical binding]; other site
65393009328	PAS domain S-box; Region: sensory_box; TIGR00229
65393009329	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393009330	putative active site [active]
65393009331	heme pocket [chemical binding]; other site
65393009332	PAS domain S-box; Region: sensory_box; TIGR00229
65393009333	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393009334	putative active site [active]
65393009335	heme pocket [chemical binding]; other site
65393009336	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393009337	GAF domain; Region: GAF_3; pfam13492
65393009338	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393009339	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393009340	metal binding site [ion binding]; metal-binding site
65393009341	active site
65393009342	I-site; other site
65393009343	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
65393009344	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
65393009345	Walker A/P-loop; other site
65393009346	ATP binding site [chemical binding]; other site
65393009347	Q-loop/lid; other site
65393009348	ABC transporter signature motif; other site
65393009349	Walker B; other site
65393009350	D-loop; other site
65393009351	H-loop/switch region; other site
65393009352	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
65393009353	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
65393009354	Walker A/P-loop; other site
65393009355	ATP binding site [chemical binding]; other site
65393009356	Q-loop/lid; other site
65393009357	ABC transporter signature motif; other site
65393009358	Walker B; other site
65393009359	D-loop; other site
65393009360	H-loop/switch region; other site
65393009361	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
65393009362	NMT1-like family; Region: NMT1_2; pfam13379
65393009363	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
65393009364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393009365	dimer interface [polypeptide binding]; other site
65393009366	conserved gate region; other site
65393009367	putative PBP binding loops; other site
65393009368	ABC-ATPase subunit interface; other site
65393009369	NMT1-like family; Region: NMT1_2; pfam13379
65393009370	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
65393009371	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
65393009372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393009373	putative substrate translocation pore; other site
65393009374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393009375	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
65393009376	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
65393009377	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
65393009378	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65393009379	putative methyltransferase; Provisional; Region: PRK11524
65393009380	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
65393009381	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
65393009382	C-terminal domain interface [polypeptide binding]; other site
65393009383	GSH binding site (G-site) [chemical binding]; other site
65393009384	dimer interface [polypeptide binding]; other site
65393009385	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
65393009386	N-terminal domain interface [polypeptide binding]; other site
65393009387	substrate binding pocket (H-site) [chemical binding]; other site
65393009388	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65393009389	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393009390	S-adenosylmethionine binding site [chemical binding]; other site
65393009391	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
65393009392	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
65393009393	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
65393009394	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
65393009395	active site
65393009396	zinc binding site [ion binding]; other site
65393009397	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393009398	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
65393009399	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
65393009400	active site
65393009401	Zn binding site [ion binding]; other site
65393009402	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393009403	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393009404	Probable transposase; Region: OrfB_IS605; pfam01385
65393009405	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393009406	S4 domain; Region: S4_2; pfam13275
65393009407	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
65393009408	nucleoside/Zn binding site; other site
65393009409	dimer interface [polypeptide binding]; other site
65393009410	catalytic motif [active]
65393009411	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
65393009412	GSH binding site [chemical binding]; other site
65393009413	catalytic residues [active]
65393009414	Circadian oscillating protein COP23; Region: COP23; pfam14218
65393009415	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
65393009416	active site
65393009417	dimer interface [polypeptide binding]; other site
65393009418	catalytic nucleophile [active]
65393009419	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393009420	putative active site [active]
65393009421	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
65393009422	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
65393009423	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
65393009424	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
65393009425	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
65393009426	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
65393009427	G1 box; other site
65393009428	putative GEF interaction site [polypeptide binding]; other site
65393009429	GTP/Mg2+ binding site [chemical binding]; other site
65393009430	Switch I region; other site
65393009431	G2 box; other site
65393009432	G3 box; other site
65393009433	Switch II region; other site
65393009434	G4 box; other site
65393009435	G5 box; other site
65393009436	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
65393009437	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
65393009438	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
65393009439	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
65393009440	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
65393009441	Probable Catalytic site; other site
65393009442	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
65393009443	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
65393009444	metal binding site [ion binding]; metal-binding site
65393009445	dimer interface [polypeptide binding]; other site
65393009446	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
65393009447	heterotetramer interface [polypeptide binding]; other site
65393009448	active site pocket [active]
65393009449	cleavage site
65393009450	Protein of unknown function (DUF433); Region: DUF433; pfam04255
65393009451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
65393009452	Caspase domain; Region: Peptidase_C14; pfam00656
65393009453	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
65393009454	Uncharacterized conserved protein [Function unknown]; Region: COG1262
65393009455	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
65393009456	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
65393009457	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
65393009458	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
65393009459	GatB domain; Region: GatB_Yqey; smart00845
65393009460	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
65393009461	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
65393009462	ligand binding site; other site
65393009463	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
65393009464	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
65393009465	B12 binding site [chemical binding]; other site
65393009466	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393009467	FeS/SAM binding site; other site
65393009468	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
65393009469	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
65393009470	putative active site [active]
65393009471	oxyanion strand; other site
65393009472	catalytic triad [active]
65393009473	Caspase domain; Region: Peptidase_C14; pfam00656
65393009474	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393009475	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393009476	metal binding site [ion binding]; metal-binding site
65393009477	active site
65393009478	I-site; other site
65393009479	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393009480	putative active site [active]
65393009481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
65393009482	Predicted kinase [General function prediction only]; Region: COG0645
65393009483	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
65393009484	ATP-binding site [chemical binding]; other site
65393009485	Gluconate-6-phosphate binding site [chemical binding]; other site
65393009486	FtsH Extracellular; Region: FtsH_ext; pfam06480
65393009487	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
65393009488	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393009489	Walker A motif; other site
65393009490	ATP binding site [chemical binding]; other site
65393009491	Walker B motif; other site
65393009492	arginine finger; other site
65393009493	Peptidase family M41; Region: Peptidase_M41; pfam01434
65393009494	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
65393009495	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393009496	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393009497	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393009498	dimer interface [polypeptide binding]; other site
65393009499	phosphorylation site [posttranslational modification]
65393009500	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393009501	ATP binding site [chemical binding]; other site
65393009502	Mg2+ binding site [ion binding]; other site
65393009503	G-X-G motif; other site
65393009504	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
65393009505	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
65393009506	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393009507	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393009508	ligand binding site [chemical binding]; other site
65393009509	flexible hinge region; other site
65393009510	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
65393009511	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
65393009512	putative active site [active]
65393009513	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393009514	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393009515	Walker A/P-loop; other site
65393009516	ATP binding site [chemical binding]; other site
65393009517	Q-loop/lid; other site
65393009518	ABC transporter signature motif; other site
65393009519	Walker B; other site
65393009520	D-loop; other site
65393009521	H-loop/switch region; other site
65393009522	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
65393009523	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
65393009524	HlyD family secretion protein; Region: HlyD_3; pfam13437
65393009525	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
65393009526	FeoA domain; Region: FeoA; pfam04023
65393009527	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
65393009528	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65393009529	Soluble P-type ATPase [General function prediction only]; Region: COG4087
65393009530	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
65393009531	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
65393009532	dimer interface [polypeptide binding]; other site
65393009533	ADP-ribose binding site [chemical binding]; other site
65393009534	active site
65393009535	nudix motif; other site
65393009536	metal binding site [ion binding]; metal-binding site
65393009537	Riboflavin synthase alpha chain [Coenzyme metabolism]; Region: RibC; COG0307
65393009538	Lumazine binding domain; Region: Lum_binding; pfam00677
65393009539	Lumazine binding domain; Region: Lum_binding; pfam00677
65393009540	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
65393009541	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
65393009542	active site
65393009543	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
65393009544	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
65393009545	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
65393009546	active site
65393009547	catalytic site [active]
65393009548	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
65393009549	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
65393009550	Cl- selectivity filter; other site
65393009551	Cl- binding residues [ion binding]; other site
65393009552	pore gating glutamate residue; other site
65393009553	dimer interface [polypeptide binding]; other site
65393009554	H+/Cl- coupling transport residue; other site
65393009555	FOG: CBS domain [General function prediction only]; Region: COG0517
65393009556	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
65393009557	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
65393009558	Ligand Binding Site [chemical binding]; other site
65393009559	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393009560	Ligand Binding Site [chemical binding]; other site
65393009561	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
65393009562	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
65393009563	Synechococcus sp. strain PCC 7942  PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162
65393009564	putative active site [active]
65393009565	putative metal binding site [ion binding]; other site
65393009566	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
65393009567	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393009568	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393009569	structural tetrad; other site
65393009570	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393009571	structural tetrad; other site
65393009572	WD40 repeats; Region: WD40; smart00320
65393009573	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905
65393009574	putative active site [active]
65393009575	Zn binding site [ion binding]; other site
65393009576	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
65393009577	Predicted flavoprotein [General function prediction only]; Region: COG0431
65393009578	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
65393009579	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
65393009580	Domain of unknown function DUF21; Region: DUF21; pfam01595
65393009581	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
65393009582	Transporter associated domain; Region: CorC_HlyC; smart01091
65393009583	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
65393009584	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393009585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393009586	active site
65393009587	phosphorylation site [posttranslational modification]
65393009588	intermolecular recognition site; other site
65393009589	dimerization interface [polypeptide binding]; other site
65393009590	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393009591	DNA binding site [nucleotide binding]
65393009592	PAS domain; Region: PAS; smart00091
65393009593	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
65393009594	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393009595	dimer interface [polypeptide binding]; other site
65393009596	phosphorylation site [posttranslational modification]
65393009597	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393009598	ATP binding site [chemical binding]; other site
65393009599	Mg2+ binding site [ion binding]; other site
65393009600	G-X-G motif; other site
65393009601	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
65393009602	PhoU domain; Region: PhoU; pfam01895
65393009603	PhoU domain; Region: PhoU; pfam01895
65393009604	S-layer homology domain; Region: SLH; pfam00395
65393009605	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
65393009606	S-layer homology domain; Region: SLH; pfam00395
65393009607	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
65393009608	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
65393009609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393009610	dimer interface [polypeptide binding]; other site
65393009611	conserved gate region; other site
65393009612	putative PBP binding loops; other site
65393009613	ABC-ATPase subunit interface; other site
65393009614	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
65393009615	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393009616	dimer interface [polypeptide binding]; other site
65393009617	conserved gate region; other site
65393009618	ABC-ATPase subunit interface; other site
65393009619	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393009620	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393009621	ligand binding site [chemical binding]; other site
65393009622	flexible hinge region; other site
65393009623	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
65393009624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393009625	Walker A motif; other site
65393009626	ATP binding site [chemical binding]; other site
65393009627	Walker B motif; other site
65393009628	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
65393009629	4Fe-4S binding domain; Region: Fer4_5; pfam12801
65393009630	4Fe-4S binding domain; Region: Fer4_5; pfam12801
65393009631	Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; pfam02427
65393009632	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
65393009633	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
65393009634	purine monophosphate binding site [chemical binding]; other site
65393009635	dimer interface [polypeptide binding]; other site
65393009636	putative catalytic residues [active]
65393009637	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
65393009638	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
65393009639	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
65393009640	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
65393009641	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
65393009642	active site
65393009643	catalytic residues [active]
65393009644	Phosphotransferase enzyme family; Region: APH; pfam01636
65393009645	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
65393009646	active site
65393009647	ATP binding site [chemical binding]; other site
65393009648	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
65393009649	substrate binding site [chemical binding]; other site
65393009650	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
65393009651	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
65393009652	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
65393009653	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
65393009654	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
65393009655	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
65393009656	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
65393009657	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
65393009658	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
65393009659	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
65393009660	NADH(P)-binding; Region: NAD_binding_10; pfam13460
65393009661	NAD(P) binding site [chemical binding]; other site
65393009662	putative active site [active]
65393009663	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
65393009664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
65393009665	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
65393009666	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393009667	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393009668	Probable transposase; Region: OrfB_IS605; pfam01385
65393009669	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
65393009670	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
65393009671	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
65393009672	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
65393009673	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
65393009674	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
65393009675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
65393009676	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393009677	ABC-ATPase subunit interface; other site
65393009678	putative PBP binding loops; other site
65393009679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393009680	dimer interface [polypeptide binding]; other site
65393009681	conserved gate region; other site
65393009682	putative PBP binding loops; other site
65393009683	ABC-ATPase subunit interface; other site
65393009684	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65393009685	non-specific DNA binding site [nucleotide binding]; other site
65393009686	salt bridge; other site
65393009687	sequence-specific DNA binding site [nucleotide binding]; other site
65393009688	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65393009689	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009690	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009691	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009692	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009693	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009694	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009695	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393009696	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
65393009697	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
65393009698	substrate binding site [chemical binding]; other site
65393009699	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
65393009700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
65393009701	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393009702	carotene isomerase; Region: carot_isom; TIGR02730
65393009703	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
65393009704	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
65393009705	substrate binding site; other site
65393009706	dimer interface; other site
65393009707	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
65393009708	heme binding pocket [chemical binding]; other site
65393009709	heme ligand [chemical binding]; other site
65393009710	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393009711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393009712	active site
65393009713	phosphorylation site [posttranslational modification]
65393009714	intermolecular recognition site; other site
65393009715	dimerization interface [polypeptide binding]; other site
65393009716	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393009717	DNA binding site [nucleotide binding]
65393009718	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
65393009719	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65393009720	catalytic triad [active]
65393009721	cobyric acid synthase; Provisional; Region: PRK00784
65393009722	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
65393009723	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
65393009724	catalytic triad [active]
65393009725	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65393009726	catalytic loop [active]
65393009727	iron binding site [ion binding]; other site
65393009728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
65393009729	DinB superfamily; Region: DinB_2; pfam12867
65393009730	Uncharacterized conserved protein [Function unknown]; Region: COG1432
65393009731	LabA_like proteins; Region: LabA; cd10911
65393009732	putative metal binding site [ion binding]; other site
65393009733	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
65393009734	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
65393009735	active site residue [active]
65393009736	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
65393009737	active site residue [active]
65393009738	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
65393009739	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
65393009740	Response regulator receiver domain; Region: Response_reg; pfam00072
65393009741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393009742	active site
65393009743	phosphorylation site [posttranslational modification]
65393009744	intermolecular recognition site; other site
65393009745	dimerization interface [polypeptide binding]; other site
65393009746	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
65393009747	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
65393009748	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
65393009749	anti sigma factor interaction site; other site
65393009750	regulatory phosphorylation site [posttranslational modification]; other site
65393009751	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
65393009752	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393009753	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
65393009754	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393009755	NAD(P) binding site [chemical binding]; other site
65393009756	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
65393009757	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
65393009758	active site
65393009759	dimer interface [polypeptide binding]; other site
65393009760	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
65393009761	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
65393009762	active site
65393009763	FMN binding site [chemical binding]; other site
65393009764	substrate binding site [chemical binding]; other site
65393009765	3Fe-4S cluster binding site [ion binding]; other site
65393009766	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
65393009767	domain interface; other site
65393009768	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393009769	putative active site [active]
65393009770	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
65393009771	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393009772	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393009773	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
65393009774	dimer interface [polypeptide binding]; other site
65393009775	motif 1; other site
65393009776	active site
65393009777	motif 2; other site
65393009778	motif 3; other site
65393009779	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
65393009780	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
65393009781	putative active site [active]
65393009782	Zn binding site [ion binding]; other site
65393009783	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
65393009784	RimK-like ATP-grasp domain; Region: RimK; pfam08443
65393009785	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
65393009786	Cytochrome c; Region: Cytochrom_C; pfam00034
65393009787	cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665
65393009788	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
65393009789	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
65393009790	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393009791	dimerization interface [polypeptide binding]; other site
65393009792	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
65393009793	Protein of unknown function (DUF760); Region: DUF760; pfam05542
65393009794	proton extrusion protein PcxA; Provisional; Region: PRK02507
65393009795	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393009796	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393009797	DNA binding residues [nucleotide binding]
65393009798	dimerization interface [polypeptide binding]; other site
65393009799	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393009800	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393009801	Phytochrome region; Region: PHY; pfam00360
65393009802	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393009803	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393009804	metal binding site [ion binding]; metal-binding site
65393009805	active site
65393009806	I-site; other site
65393009807	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393009808	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393009809	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393009810	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393009811	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393009812	metal binding site [ion binding]; metal-binding site
65393009813	active site
65393009814	I-site; other site
65393009815	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
65393009816	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
65393009817	putative catalytic cysteine [active]
65393009818	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
65393009819	putative active site [active]
65393009820	metal binding site [ion binding]; metal-binding site
65393009821	isocitrate dehydrogenase; Validated; Region: PRK06451
65393009822	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
65393009823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393009824	S-adenosylmethionine binding site [chemical binding]; other site
65393009825	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
65393009826	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
65393009827	ABC1 family; Region: ABC1; cl17513
65393009828	HupF/HypC family; Region: HupF_HypC; pfam01455
65393009829	Acylphosphatase; Region: Acylphosphatase; pfam00708
65393009830	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
65393009831	HypF finger; Region: zf-HYPF; pfam07503
65393009832	HypF finger; Region: zf-HYPF; pfam07503
65393009833	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
65393009834	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
65393009835	dimerization interface [polypeptide binding]; other site
65393009836	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
65393009837	ATP binding site [chemical binding]; other site
65393009838	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
65393009839	UbiA prenyltransferase family; Region: UbiA; pfam01040
65393009840	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
65393009841	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
65393009842	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
65393009843	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65393009844	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
65393009845	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
65393009846	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
65393009847	active site
65393009848	catalytic site [active]
65393009849	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
65393009850	Phosphate acyltransferases; Region: PlsC; smart00563
65393009851	putative acyl-acceptor binding pocket; other site
65393009852	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
65393009853	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
65393009854	CHAD domain; Region: CHAD; cl10506
65393009855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393009856	putative substrate translocation pore; other site
65393009857	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
65393009858	serine O-acetyltransferase; Region: cysE; TIGR01172
65393009859	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
65393009860	trimer interface [polypeptide binding]; other site
65393009861	active site
65393009862	substrate binding site [chemical binding]; other site
65393009863	CoA binding site [chemical binding]; other site
65393009864	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
65393009865	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
65393009866	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
65393009867	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
65393009868	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
65393009869	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
65393009870	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
65393009871	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
65393009872	putative translocon binding site; other site
65393009873	protein-rRNA interface [nucleotide binding]; other site
65393009874	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
65393009875	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
65393009876	G-X-X-G motif; other site
65393009877	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
65393009878	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
65393009879	23S rRNA interface [nucleotide binding]; other site
65393009880	5S rRNA interface [nucleotide binding]; other site
65393009881	putative antibiotic binding site [chemical binding]; other site
65393009882	L25 interface [polypeptide binding]; other site
65393009883	L27 interface [polypeptide binding]; other site
65393009884	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
65393009885	putative translocon interaction site; other site
65393009886	23S rRNA interface [nucleotide binding]; other site
65393009887	signal recognition particle (SRP54) interaction site; other site
65393009888	L23 interface [polypeptide binding]; other site
65393009889	trigger factor interaction site; other site
65393009890	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
65393009891	ribosomal protein L14; Region: rpl14; CHL00057
65393009892	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
65393009893	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
65393009894	RNA binding site [nucleotide binding]; other site
65393009895	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
65393009896	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
65393009897	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
65393009898	ribosomal protein S8; Region: rps8; CHL00042
65393009899	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
65393009900	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
65393009901	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
65393009902	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
65393009903	23S rRNA interface [nucleotide binding]; other site
65393009904	L21e interface [polypeptide binding]; other site
65393009905	5S rRNA interface [nucleotide binding]; other site
65393009906	L27 interface [polypeptide binding]; other site
65393009907	L5 interface [polypeptide binding]; other site
65393009908	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
65393009909	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
65393009910	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
65393009911	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
65393009912	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
65393009913	SecY translocase; Region: SecY; pfam00344
65393009914	adenylate kinase; Provisional; Region: adk; PRK02496
65393009915	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
65393009916	AMP-binding site [chemical binding]; other site
65393009917	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
65393009918	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
65393009919	rRNA binding site [nucleotide binding]; other site
65393009920	predicted 30S ribosome binding site; other site
65393009921	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
65393009922	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
65393009923	30S ribosomal protein S13; Region: bact_S13; TIGR03631
65393009924	30S ribosomal protein S11; Validated; Region: PRK05309
65393009925	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
65393009926	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
65393009927	alphaNTD homodimer interface [polypeptide binding]; other site
65393009928	alphaNTD - beta interaction site [polypeptide binding]; other site
65393009929	alphaNTD - beta' interaction site [polypeptide binding]; other site
65393009930	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
65393009931	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
65393009932	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
65393009933	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
65393009934	dimerization interface 3.5A [polypeptide binding]; other site
65393009935	active site
65393009936	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
65393009937	23S rRNA interface [nucleotide binding]; other site
65393009938	L3 interface [polypeptide binding]; other site
65393009939	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
65393009940	ribosomal protein L31; Validated; Region: rpl31; CHL00136
65393009941	peptide chain release factor 1; Validated; Region: prfA; PRK00591
65393009942	This domain is found in peptide chain release factors; Region: PCRF; smart00937
65393009943	RF-1 domain; Region: RF-1; pfam00472
65393009944	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393009945	putative active site [active]
65393009946	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393009947	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393009948	ligand binding site [chemical binding]; other site
65393009949	flexible hinge region; other site
65393009950	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
65393009951	non-specific DNA interactions [nucleotide binding]; other site
65393009952	DNA binding site [nucleotide binding]
65393009953	sequence specific DNA binding site [nucleotide binding]; other site
65393009954	putative cAMP binding site [chemical binding]; other site
65393009955	Electron transfer DM13; Region: DM13; pfam10517
65393009956	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
65393009957	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
65393009958	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
65393009959	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393009960	ATP binding site [chemical binding]; other site
65393009961	putative Mg++ binding site [ion binding]; other site
65393009962	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65393009963	nucleotide binding region [chemical binding]; other site
65393009964	ATP-binding site [chemical binding]; other site
65393009965	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
65393009966	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393009967	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
65393009968	adenylosuccinate lyase; Provisional; Region: PRK07380
65393009969	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
65393009970	tetramer interface [polypeptide binding]; other site
65393009971	active site
65393009972	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
65393009973	cysteine synthase; Region: PLN02565
65393009974	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
65393009975	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65393009976	active site
65393009977	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
65393009978	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
65393009979	Domain of unknown function (DUF309); Region: DUF309; pfam03745
65393009980	OstA-like protein; Region: OstA; pfam03968
65393009981	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
65393009982	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
65393009983	Walker A/P-loop; other site
65393009984	ATP binding site [chemical binding]; other site
65393009985	Q-loop/lid; other site
65393009986	ABC transporter signature motif; other site
65393009987	Walker B; other site
65393009988	D-loop; other site
65393009989	H-loop/switch region; other site
65393009990	Predicted permeases [General function prediction only]; Region: COG0795
65393009991	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
65393009992	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
65393009993	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
65393009994	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
65393009995	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
65393009996	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
65393009997	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
65393009998	homodimer interface [polypeptide binding]; other site
65393009999	substrate-cofactor binding pocket; other site
65393010000	Aminotransferase class IV; Region: Aminotran_4; pfam01063
65393010001	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393010002	catalytic residue [active]
65393010003	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
65393010004	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
65393010005	substrate binding pocket [chemical binding]; other site
65393010006	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65393010007	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
65393010008	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
65393010009	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
65393010010	NAD(P) binding site [chemical binding]; other site
65393010011	catalytic residues [active]
65393010012	Protein of unknown function DUF104; Region: DUF104; pfam01954
65393010013	XPG N-terminal domain; Region: XPG_N; cl02628
65393010014	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
65393010015	elongation factor G; Reviewed; Region: PRK12740
65393010016	G1 box; other site
65393010017	putative GEF interaction site [polypeptide binding]; other site
65393010018	GTP/Mg2+ binding site [chemical binding]; other site
65393010019	Switch I region; other site
65393010020	G2 box; other site
65393010021	G3 box; other site
65393010022	Switch II region; other site
65393010023	G4 box; other site
65393010024	G5 box; other site
65393010025	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
65393010026	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
65393010027	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
65393010028	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
65393010029	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393010030	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393010031	Response regulator receiver domain; Region: Response_reg; pfam00072
65393010032	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393010033	active site
65393010034	phosphorylation site [posttranslational modification]
65393010035	intermolecular recognition site; other site
65393010036	dimerization interface [polypeptide binding]; other site
65393010037	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393010038	PAS fold; Region: PAS_3; pfam08447
65393010039	putative active site [active]
65393010040	heme pocket [chemical binding]; other site
65393010041	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
65393010042	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393010043	dimer interface [polypeptide binding]; other site
65393010044	phosphorylation site [posttranslational modification]
65393010045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393010046	ATP binding site [chemical binding]; other site
65393010047	Mg2+ binding site [ion binding]; other site
65393010048	G-X-G motif; other site
65393010049	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393010050	dimerization interface [polypeptide binding]; other site
65393010051	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393010052	dimer interface [polypeptide binding]; other site
65393010053	phosphorylation site [posttranslational modification]
65393010054	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393010055	ATP binding site [chemical binding]; other site
65393010056	Mg2+ binding site [ion binding]; other site
65393010057	G-X-G motif; other site
65393010058	Response regulator receiver domain; Region: Response_reg; pfam00072
65393010059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393010060	active site
65393010061	phosphorylation site [posttranslational modification]
65393010062	intermolecular recognition site; other site
65393010063	dimerization interface [polypeptide binding]; other site
65393010064	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
65393010065	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393010066	dimerization interface [polypeptide binding]; other site
65393010067	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393010068	dimerization interface [polypeptide binding]; other site
65393010069	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393010070	dimerization interface [polypeptide binding]; other site
65393010071	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393010072	dimerization interface [polypeptide binding]; other site
65393010073	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
65393010074	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393010075	dimerization interface [polypeptide binding]; other site
65393010076	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393010077	dimerization interface [polypeptide binding]; other site
65393010078	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393010079	dimerization interface [polypeptide binding]; other site
65393010080	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393010081	dimerization interface [polypeptide binding]; other site
65393010082	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393010083	GAF domain; Region: GAF; pfam01590
65393010084	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393010085	dimer interface [polypeptide binding]; other site
65393010086	phosphorylation site [posttranslational modification]
65393010087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393010088	ATP binding site [chemical binding]; other site
65393010089	Mg2+ binding site [ion binding]; other site
65393010090	G-X-G motif; other site
65393010091	Response regulator receiver domain; Region: Response_reg; pfam00072
65393010092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393010093	active site
65393010094	phosphorylation site [posttranslational modification]
65393010095	intermolecular recognition site; other site
65393010096	dimerization interface [polypeptide binding]; other site
65393010097	Response regulator receiver domain; Region: Response_reg; pfam00072
65393010098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393010099	active site
65393010100	phosphorylation site [posttranslational modification]
65393010101	intermolecular recognition site; other site
65393010102	dimerization interface [polypeptide binding]; other site
65393010103	aspartoacylase; Provisional; Region: PRK02259
65393010104	FG-GAP repeat; Region: FG-GAP_2; pfam14312
65393010105	PQQ-like domain; Region: PQQ_2; pfam13360
65393010106	FG-GAP repeat; Region: FG-GAP_2; pfam14312
65393010107	FG-GAP repeat; Region: FG-GAP_2; pfam14312
65393010108	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
65393010109	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
65393010110	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
65393010111	DHH family; Region: DHH; pfam01368
65393010112	DHHA1 domain; Region: DHHA1; pfam02272
65393010113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393010114	Response regulator receiver domain; Region: Response_reg; pfam00072
65393010115	active site
65393010116	phosphorylation site [posttranslational modification]
65393010117	intermolecular recognition site; other site
65393010118	dimerization interface [polypeptide binding]; other site
65393010119	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
65393010120	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393010121	FeS/SAM binding site; other site
65393010122	sucrose synthase; Region: sucr_synth; TIGR02470
65393010123	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
65393010124	putative ADP-binding pocket [chemical binding]; other site
65393010125	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
65393010126	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
65393010127	active site
65393010128	dimer interface [polypeptide binding]; other site
65393010129	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
65393010130	dimer interface [polypeptide binding]; other site
65393010131	active site
65393010132	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
65393010133	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
65393010134	NAD binding site [chemical binding]; other site
65393010135	dimer interface [polypeptide binding]; other site
65393010136	substrate binding site [chemical binding]; other site
65393010137	tetramer (dimer of dimers) interface [polypeptide binding]; other site
65393010138	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393010139	Ligand Binding Site [chemical binding]; other site
65393010140	Predicted membrane protein [Function unknown]; Region: COG4803
65393010141	putative phosphoketolase; Provisional; Region: PRK05261
65393010142	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
65393010143	TPP-binding site; other site
65393010144	XFP C-terminal domain; Region: XFP_C; pfam09363
65393010145	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
65393010146	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
65393010147	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
65393010148	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
65393010149	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
65393010150	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
65393010151	active site
65393010152	catalytic site [active]
65393010153	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
65393010154	putative catalytic site [active]
65393010155	putative metal binding site [ion binding]; other site
65393010156	putative phosphate binding site [ion binding]; other site
65393010157	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
65393010158	putative catalytic site [active]
65393010159	putative phosphate binding site [ion binding]; other site
65393010160	putative metal binding site [ion binding]; other site
65393010161	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
65393010162	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
65393010163	putative dimer interface [polypeptide binding]; other site
65393010164	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
65393010165	Predicted membrane protein [Function unknown]; Region: COG2259
65393010166	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
65393010167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393010168	S-adenosylmethionine binding site [chemical binding]; other site
65393010169	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
65393010170	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65393010171	catalytic loop [active]
65393010172	iron binding site [ion binding]; other site
65393010173	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
65393010174	Domain of unknown function DUF20; Region: UPF0118; pfam01594
65393010175	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393010176	Ligand Binding Site [chemical binding]; other site
65393010177	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
65393010178	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
65393010179	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393010180	catalytic residue [active]
65393010181	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
65393010182	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
65393010183	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
65393010184	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
65393010185	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
65393010186	catalytic site [active]
65393010187	putative active site [active]
65393010188	putative substrate binding site [chemical binding]; other site
65393010189	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
65393010190	active site
65393010191	ribulose/triose binding site [chemical binding]; other site
65393010192	phosphate binding site [ion binding]; other site
65393010193	substrate (anthranilate) binding pocket [chemical binding]; other site
65393010194	product (indole) binding pocket [chemical binding]; other site
65393010195	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
65393010196	homodimer interface [polypeptide binding]; other site
65393010197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393010198	catalytic residue [active]
65393010199	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65393010200	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393010201	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393010202	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393010203	ligand binding site [chemical binding]; other site
65393010204	flexible hinge region; other site
65393010205	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
65393010206	SNF2 Helicase protein; Region: DUF3670; pfam12419
65393010207	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393010208	ATP binding site [chemical binding]; other site
65393010209	putative Mg++ binding site [ion binding]; other site
65393010210	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65393010211	nucleotide binding region [chemical binding]; other site
65393010212	ATP-binding site [chemical binding]; other site
65393010213	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65393010214	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393010215	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393010216	TPR repeat; Region: TPR_11; pfam13414
65393010217	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393010218	binding surface
65393010219	TPR motif; other site
65393010220	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
65393010221	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
65393010222	Catalytic site [active]
65393010223	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
65393010224	AIR carboxylase; Region: AIRC; smart01001
65393010225	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65393010226	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393010227	S-adenosylmethionine binding site [chemical binding]; other site
65393010228	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
65393010229	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
65393010230	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65393010231	TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949
65393010232	catalytic residues [active]
65393010233	Uncharacterized conserved protein [Function unknown]; Region: COG1434
65393010234	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
65393010235	putative active site [active]
65393010236	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
65393010237	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
65393010238	Double zinc ribbon; Region: DZR; pfam12773
65393010239	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65393010240	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393010241	phosphopeptide binding site; other site
65393010242	Predicted membrane protein [Function unknown]; Region: COG2261
65393010243	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
65393010244	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
65393010245	active site
65393010246	cobalt transport protein CbiM; Validated; Region: PRK08319
65393010247	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
65393010248	cobalt transport protein CbiN; Provisional; Region: PRK02898
65393010249	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
65393010250	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65393010251	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
65393010252	Walker A/P-loop; other site
65393010253	ATP binding site [chemical binding]; other site
65393010254	Q-loop/lid; other site
65393010255	ABC transporter signature motif; other site
65393010256	Walker B; other site
65393010257	D-loop; other site
65393010258	H-loop/switch region; other site
65393010259	tocopherol O-methyltransferase; Region: PLN02244
65393010260	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393010261	S-adenosylmethionine binding site [chemical binding]; other site
65393010262	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65393010263	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
65393010264	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65393010265	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393010266	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
65393010267	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
65393010268	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
65393010269	Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795
65393010270	linker region; other site
65393010271	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
65393010272	Uncharacterized conserved protein [Function unknown]; Region: COG5361
65393010273	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
65393010274	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
65393010275	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
65393010276	Sulfatase; Region: Sulfatase; pfam00884
65393010277	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
65393010278	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
65393010279	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
65393010280	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
65393010281	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
65393010282	Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865
65393010283	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
65393010284	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
65393010285	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
65393010286	dimer interface [polypeptide binding]; other site
65393010287	active site
65393010288	aspartate-rich active site metal binding site; other site
65393010289	allosteric magnesium binding site [ion binding]; other site
65393010290	Schiff base residues; other site
65393010291	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
65393010292	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
65393010293	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65393010294	active site
65393010295	metal binding site [ion binding]; metal-binding site
65393010296	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
65393010297	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
65393010298	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
65393010299	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
65393010300	homodecamer interface [polypeptide binding]; other site
65393010301	GTP cyclohydrolase I; Provisional; Region: PLN03044
65393010302	active site
65393010303	putative catalytic site residues [active]
65393010304	zinc binding site [ion binding]; other site
65393010305	GTP-CH-I/GFRP interaction surface; other site
65393010306	Methyltransferase domain; Region: Methyltransf_26; pfam13659
65393010307	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393010308	ATP binding site [chemical binding]; other site
65393010309	putative Mg++ binding site [ion binding]; other site
65393010310	Helicase_C-like; Region: Helicase_C_4; pfam13871
65393010311	Protein of unknown function (DUF433); Region: DUF433; pfam04255
65393010312	DDE superfamily endonuclease; Region: DDE_3; pfam13358
65393010313	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
65393010314	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
65393010315	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393010316	DDE superfamily endonuclease; Region: DDE_4; pfam13359
65393010317	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
65393010318	nucleotide binding site [chemical binding]; other site
65393010319	NB-ARC domain; Region: NB-ARC; pfam00931
65393010320	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010321	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393010322	binding surface
65393010323	TPR motif; other site
65393010324	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010325	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393010326	binding surface
65393010327	TPR motif; other site
65393010328	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010329	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
65393010330	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
65393010331	active site
65393010332	interdomain interaction site; other site
65393010333	putative metal-binding site [ion binding]; other site
65393010334	nucleotide binding site [chemical binding]; other site
65393010335	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
65393010336	domain I; other site
65393010337	DNA binding groove [nucleotide binding]
65393010338	phosphate binding site [ion binding]; other site
65393010339	domain II; other site
65393010340	domain III; other site
65393010341	nucleotide binding site [chemical binding]; other site
65393010342	catalytic site [active]
65393010343	domain IV; other site
65393010344	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
65393010345	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
65393010346	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
65393010347	substrate binding site [chemical binding]; other site
65393010348	dimer interface [polypeptide binding]; other site
65393010349	ATP binding site [chemical binding]; other site
65393010350	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
65393010351	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65393010352	active site
65393010353	metal binding site [ion binding]; metal-binding site
65393010354	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
65393010355	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
65393010356	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
65393010357	ligand binding site [chemical binding]; other site
65393010358	hypothetical protein; Provisional; Region: PRK11281
65393010359	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
65393010360	DinB family; Region: DinB; cl17821
65393010361	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
65393010362	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
65393010363	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
65393010364	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393010365	DDE superfamily endonuclease; Region: DDE_4; pfam13359
65393010366	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
65393010367	AAA-like domain; Region: AAA_10; pfam12846
65393010368	Uncharacterized conserved protein [Function unknown]; Region: COG2442
65393010369	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
65393010370	Uncharacterized conserved protein [Function unknown]; Region: COG2361
65393010371	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65393010372	active site
65393010373	NTP binding site [chemical binding]; other site
65393010374	metal binding triad [ion binding]; metal-binding site
65393010375	antibiotic binding site [chemical binding]; other site
65393010376	HsdM N-terminal domain; Region: HsdM_N; pfam12161
65393010377	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
65393010378	Methyltransferase domain; Region: Methyltransf_26; pfam13659
65393010379	S-adenosylmethionine binding site [chemical binding]; other site
65393010380	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
65393010381	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393010382	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393010383	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393010384	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393010385	ATP binding site [chemical binding]; other site
65393010386	putative Mg++ binding site [ion binding]; other site
65393010387	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
65393010388	Transposase; Region: DDE_Tnp_ISL3; pfam01610
65393010389	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
65393010390	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
65393010391	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
65393010392	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65393010393	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
65393010394	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393010395	motif II; other site
65393010396	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
65393010397	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
65393010398	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
65393010399	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65393010400	catalytic residue [active]
65393010401	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393010402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393010403	active site
65393010404	phosphorylation site [posttranslational modification]
65393010405	intermolecular recognition site; other site
65393010406	dimerization interface [polypeptide binding]; other site
65393010407	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393010408	DNA binding site [nucleotide binding]
65393010409	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393010410	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393010411	dimer interface [polypeptide binding]; other site
65393010412	phosphorylation site [posttranslational modification]
65393010413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393010414	ATP binding site [chemical binding]; other site
65393010415	Mg2+ binding site [ion binding]; other site
65393010416	G-X-G motif; other site
65393010417	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
65393010418	Domain of unknown function DUF20; Region: UPF0118; pfam01594
65393010419	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
65393010420	Bacteriorhodopsin [General function prediction only]; Region: COG5524
65393010421	trehalose synthase; Region: treS_nterm; TIGR02456
65393010422	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
65393010423	active site
65393010424	catalytic site [active]
65393010425	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
65393010426	glucose-1-dehydrogenase; Provisional; Region: PRK08936
65393010427	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
65393010428	NAD binding site [chemical binding]; other site
65393010429	homodimer interface [polypeptide binding]; other site
65393010430	active site
65393010431	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
65393010432	DDE superfamily endonuclease; Region: DDE_4; cl17710
65393010433	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
65393010434	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
65393010435	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
65393010436	active site
65393010437	catalytic residues [active]
65393010438	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
65393010439	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
65393010440	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
65393010441	putative C-terminal domain interface [polypeptide binding]; other site
65393010442	putative GSH binding site (G-site) [chemical binding]; other site
65393010443	putative dimer interface [polypeptide binding]; other site
65393010444	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
65393010445	putative N-terminal domain interface [polypeptide binding]; other site
65393010446	putative dimer interface [polypeptide binding]; other site
65393010447	putative substrate binding pocket (H-site) [chemical binding]; other site
65393010448	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65393010449	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65393010450	Tetratricopeptide repeat; Region: TPR_2; pfam07719
65393010451	TPR repeat; Region: TPR_11; pfam13414
65393010452	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393010453	binding surface
65393010454	TPR motif; other site
65393010455	TPR repeat; Region: TPR_11; pfam13414
65393010456	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
65393010457	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
65393010458	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
65393010459	cytochrome b subunit interaction site [polypeptide binding]; other site
65393010460	[2Fe-2S] cluster binding site [ion binding]; other site
65393010461	cytochrome f; Region: petA; CHL00037
65393010462	apocytochrome f; Reviewed; Region: PRK02693
65393010463	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
65393010464	metal binding site 2 [ion binding]; metal-binding site
65393010465	putative DNA binding helix; other site
65393010466	metal binding site 1 [ion binding]; metal-binding site
65393010467	dimer interface [polypeptide binding]; other site
65393010468	structural Zn2+ binding site [ion binding]; other site
65393010469	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
65393010470	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
65393010471	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
65393010472	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
65393010473	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393010474	active site
65393010475	ATP binding site [chemical binding]; other site
65393010476	substrate binding site [chemical binding]; other site
65393010477	activation loop (A-loop); other site
65393010478	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
65393010479	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65393010480	active site
65393010481	ribonuclease III; Reviewed; Region: rnc; PRK00102
65393010482	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
65393010483	dimerization interface [polypeptide binding]; other site
65393010484	active site
65393010485	metal binding site [ion binding]; metal-binding site
65393010486	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
65393010487	dsRNA binding site [nucleotide binding]; other site
65393010488	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
65393010489	patatin-related protein; Region: TIGR03607
65393010490	Patatin-like phospholipase; Region: Patatin; pfam01734
65393010491	nucleophile elbow; other site
65393010492	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
65393010493	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
65393010494	tandem repeat interface [polypeptide binding]; other site
65393010495	oligomer interface [polypeptide binding]; other site
65393010496	active site residues [active]
65393010497	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
65393010498	tandem repeat interface [polypeptide binding]; other site
65393010499	oligomer interface [polypeptide binding]; other site
65393010500	active site residues [active]
65393010501	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
65393010502	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
65393010503	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65393010504	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
65393010505	phosphoenolpyruvate synthase; Validated; Region: PRK06464
65393010506	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
65393010507	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
65393010508	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
65393010509	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393010510	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65393010511	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393010512	Walker A/P-loop; other site
65393010513	ATP binding site [chemical binding]; other site
65393010514	Q-loop/lid; other site
65393010515	ABC transporter signature motif; other site
65393010516	Walker B; other site
65393010517	D-loop; other site
65393010518	H-loop/switch region; other site
65393010519	Response regulator receiver domain; Region: Response_reg; pfam00072
65393010520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393010521	active site
65393010522	phosphorylation site [posttranslational modification]
65393010523	intermolecular recognition site; other site
65393010524	dimerization interface [polypeptide binding]; other site
65393010525	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
65393010526	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
65393010527	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
65393010528	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
65393010529	non-specific DNA interactions [nucleotide binding]; other site
65393010530	DNA binding site [nucleotide binding]
65393010531	sequence specific DNA binding site [nucleotide binding]; other site
65393010532	putative cAMP binding site [chemical binding]; other site
65393010533	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
65393010534	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
65393010535	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
65393010536	substrate binding site [chemical binding]; other site
65393010537	catalytic Zn binding site [ion binding]; other site
65393010538	NAD binding site [chemical binding]; other site
65393010539	structural Zn binding site [ion binding]; other site
65393010540	dimer interface [polypeptide binding]; other site
65393010541	Predicted membrane protein [Function unknown]; Region: COG2259
65393010542	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393010543	Probable transposase; Region: OrfB_IS605; pfam01385
65393010544	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393010545	Coenzyme A binding pocket [chemical binding]; other site
65393010546	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
65393010547	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
65393010548	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
65393010549	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
65393010550	intersubunit interface [polypeptide binding]; other site
65393010551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393010552	muropeptide transporter; Reviewed; Region: ampG; PRK11902
65393010553	putative substrate translocation pore; other site
65393010554	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65393010555	catalytic core [active]
65393010556	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
65393010557	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
65393010558	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
65393010559	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
65393010560	active site
65393010561	nucleophile elbow; other site
65393010562	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
65393010563	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65393010564	active site
65393010565	metal binding site [ion binding]; metal-binding site
65393010566	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
65393010567	active site
65393010568	dinuclear metal binding site [ion binding]; other site
65393010569	dimerization interface [polypeptide binding]; other site
65393010570	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
65393010571	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393010572	Coenzyme A binding pocket [chemical binding]; other site
65393010573	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393010574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393010575	active site
65393010576	phosphorylation site [posttranslational modification]
65393010577	intermolecular recognition site; other site
65393010578	dimerization interface [polypeptide binding]; other site
65393010579	RDD family; Region: RDD; pfam06271
65393010580	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393010581	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393010582	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393010583	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393010584	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393010585	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393010586	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393010587	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
65393010588	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393010589	binding surface
65393010590	TPR motif; other site
65393010591	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
65393010592	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
65393010593	active site
65393010594	catalytic triad [active]
65393010595	oxyanion hole [active]
65393010596	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
65393010597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393010598	S-adenosylmethionine binding site [chemical binding]; other site
65393010599	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
65393010600	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
65393010601	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
65393010602	putative active site; other site
65393010603	catalytic residue [active]
65393010604	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
65393010605	Peptidase family M50; Region: Peptidase_M50; pfam02163
65393010606	active site
65393010607	putative substrate binding region [chemical binding]; other site
65393010608	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
65393010609	DNA adenine methylase (dam); Region: dam; TIGR00571
65393010610	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
65393010611	dihydropteroate synthase; Region: DHPS; TIGR01496
65393010612	substrate binding pocket [chemical binding]; other site
65393010613	dimer interface [polypeptide binding]; other site
65393010614	inhibitor binding site; inhibition site
65393010615	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
65393010616	triosephosphate isomerase; Provisional; Region: PRK14565
65393010617	substrate binding site [chemical binding]; other site
65393010618	dimer interface [polypeptide binding]; other site
65393010619	catalytic triad [active]
65393010620	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
65393010621	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
65393010622	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
65393010623	Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596
65393010624	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
65393010625	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
65393010626	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
65393010627	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
65393010628	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
65393010629	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
65393010630	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393010631	putative active site [active]
65393010632	aspartate aminotransferase; Provisional; Region: PRK05942
65393010633	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65393010634	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393010635	homodimer interface [polypeptide binding]; other site
65393010636	catalytic residue [active]
65393010637	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
65393010638	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393010639	Coenzyme A binding pocket [chemical binding]; other site
65393010640	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
65393010641	GAF domain; Region: GAF; pfam01590
65393010642	Phytochrome region; Region: PHY; pfam00360
65393010643	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393010644	dimer interface [polypeptide binding]; other site
65393010645	phosphorylation site [posttranslational modification]
65393010646	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393010647	ATP binding site [chemical binding]; other site
65393010648	Mg2+ binding site [ion binding]; other site
65393010649	G-X-G motif; other site
65393010650	Response regulator receiver domain; Region: Response_reg; pfam00072
65393010651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393010652	active site
65393010653	phosphorylation site [posttranslational modification]
65393010654	intermolecular recognition site; other site
65393010655	dimerization interface [polypeptide binding]; other site
65393010656	enolase; Provisional; Region: eno; PRK00077
65393010657	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
65393010658	dimer interface [polypeptide binding]; other site
65393010659	metal binding site [ion binding]; metal-binding site
65393010660	substrate binding pocket [chemical binding]; other site
65393010661	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
65393010662	Protein of unknown function (DUF760); Region: DUF760; pfam05542
65393010663	hydrolase, alpha/beta fold family protein; Region: PLN02824
65393010664	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65393010665	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
65393010666	catalytic site [active]
65393010667	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
65393010668	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
65393010669	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
65393010670	active site
65393010671	Riboflavin kinase; Region: Flavokinase; pfam01687
65393010672	MoxR-like ATPases [General function prediction only]; Region: COG0714
65393010673	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393010674	Walker A motif; other site
65393010675	ATP binding site [chemical binding]; other site
65393010676	Walker B motif; other site
65393010677	arginine finger; other site
65393010678	Dihaem cytochrome c; Region: DHC; pfam09626
65393010679	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
65393010680	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65393010681	putative catalytic residue [active]
65393010682	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
65393010683	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393010684	motif I; other site
65393010685	active site
65393010686	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
65393010687	4Fe-4S binding domain; Region: Fer4; cl02805
65393010688	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
65393010689	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
65393010690	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
65393010691	arginine decarboxylase; Provisional; Region: PRK05354
65393010692	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
65393010693	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
65393010694	dimer interface [polypeptide binding]; other site
65393010695	active site
65393010696	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
65393010697	catalytic residues [active]
65393010698	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
65393010699	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
65393010700	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
65393010701	B12 binding site [chemical binding]; other site
65393010702	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393010703	FeS/SAM binding site; other site
65393010704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
65393010705	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
65393010706	mechanosensitive channel MscS; Provisional; Region: PRK10334
65393010707	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393010708	light-harvesting-like protein 3; Provisional; Region: PLN00014
65393010709	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393010710	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
65393010711	Walker A motif; other site
65393010712	ATP binding site [chemical binding]; other site
65393010713	Walker B motif; other site
65393010714	arginine finger; other site
65393010715	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
65393010716	metal ion-dependent adhesion site (MIDAS); other site
65393010717	The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424
65393010718	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
65393010719	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
65393010720	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
65393010721	putative active site [active]
65393010722	catalytic site [active]
65393010723	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
65393010724	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
65393010725	trimer interface [polypeptide binding]; other site
65393010726	active site
65393010727	substrate binding site [chemical binding]; other site
65393010728	CoA binding site [chemical binding]; other site
65393010729	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
65393010730	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
65393010731	C-terminal domain interface [polypeptide binding]; other site
65393010732	GSH binding site (G-site) [chemical binding]; other site
65393010733	dimer interface [polypeptide binding]; other site
65393010734	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
65393010735	N-terminal domain interface [polypeptide binding]; other site
65393010736	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
65393010737	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
65393010738	active site
65393010739	dimer interface [polypeptide binding]; other site
65393010740	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
65393010741	isocitrate lyase; Provisional; Region: PRK15063
65393010742	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
65393010743	tetramer interface [polypeptide binding]; other site
65393010744	active site
65393010745	Mg2+/Mn2+ binding site [ion binding]; other site
65393010746	malate synthase A; Region: malate_syn_A; TIGR01344
65393010747	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
65393010748	active site
65393010749	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
65393010750	SnoaL-like domain; Region: SnoaL_3; pfam13474
65393010751	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
65393010752	active site residue [active]
65393010753	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
65393010754	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65393010755	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393010756	homodimer interface [polypeptide binding]; other site
65393010757	catalytic residue [active]
65393010758	Protein of unknown function (DUF563); Region: DUF563; pfam04577
65393010759	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
65393010760	TPP-binding site [chemical binding]; other site
65393010761	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
65393010762	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
65393010763	PYR/PP interface [polypeptide binding]; other site
65393010764	dimer interface [polypeptide binding]; other site
65393010765	TPP binding site [chemical binding]; other site
65393010766	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
65393010767	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
65393010768	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
65393010769	active site
65393010770	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393010771	Probable transposase; Region: OrfB_IS605; pfam01385
65393010772	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393010773	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
65393010774	transketolase; Region: PLN02790
65393010775	TPP-binding site [chemical binding]; other site
65393010776	dimer interface [polypeptide binding]; other site
65393010777	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
65393010778	PYR/PP interface [polypeptide binding]; other site
65393010779	dimer interface [polypeptide binding]; other site
65393010780	TPP binding site [chemical binding]; other site
65393010781	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
65393010782	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
65393010783	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
65393010784	dimer interface [polypeptide binding]; other site
65393010785	active site
65393010786	acyl carrier protein; Provisional; Region: acpP; PRK00982
65393010787	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
65393010788	Cysteine-rich domain; Region: CCG; pfam02754
65393010789	Cysteine-rich domain; Region: CCG; pfam02754
65393010790	acylphosphatase; Provisional; Region: PRK14423
65393010791	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
65393010792	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
65393010793	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
65393010794	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
65393010795	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
65393010796	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
65393010797	Subunit I/III interface [polypeptide binding]; other site
65393010798	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
65393010799	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
65393010800	active site
65393010801	substrate binding site [chemical binding]; other site
65393010802	metal binding site [ion binding]; metal-binding site
65393010803	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
65393010804	CP12 domain; Region: CP12; pfam02672
65393010805	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
65393010806	FIST N domain; Region: FIST; pfam08495
65393010807	FIST C domain; Region: FIST_C; pfam10442
65393010808	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65393010809	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65393010810	active site
65393010811	AAA ATPase domain; Region: AAA_16; pfam13191
65393010812	NB-ARC domain; Region: NB-ARC; pfam00931
65393010813	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010814	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393010815	binding surface
65393010816	TPR motif; other site
65393010817	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010818	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010819	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393010820	binding surface
65393010821	TPR motif; other site
65393010822	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010823	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393010824	binding surface
65393010825	TPR motif; other site
65393010826	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010827	Predicted permease; Region: DUF318; cl17795
65393010828	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
65393010829	DHH family; Region: DHH; pfam01368
65393010830	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65393010831	catalytic core [active]
65393010832	citrate synthase; Provisional; Region: PRK14036
65393010833	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
65393010834	oxalacetate binding site [chemical binding]; other site
65393010835	citrylCoA binding site [chemical binding]; other site
65393010836	coenzyme A binding site [chemical binding]; other site
65393010837	catalytic triad [active]
65393010838	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393010839	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393010840	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393010841	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393010842	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393010843	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393010844	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65393010845	dimer interface [polypeptide binding]; other site
65393010846	putative CheW interface [polypeptide binding]; other site
65393010847	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
65393010848	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
65393010849	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65393010850	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
65393010851	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
65393010852	active site
65393010853	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
65393010854	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
65393010855	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393010856	dimerization interface [polypeptide binding]; other site
65393010857	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393010858	dimer interface [polypeptide binding]; other site
65393010859	phosphorylation site [posttranslational modification]
65393010860	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393010861	ATP binding site [chemical binding]; other site
65393010862	Mg2+ binding site [ion binding]; other site
65393010863	G-X-G motif; other site
65393010864	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393010865	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393010866	putative active site [active]
65393010867	magnesium chelatase subunit H; Provisional; Region: PLN03241
65393010868	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
65393010869	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
65393010870	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
65393010871	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
65393010872	ATP-NAD kinase; Region: NAD_kinase; pfam01513
65393010873	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65393010874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393010875	S-adenosylmethionine binding site [chemical binding]; other site
65393010876	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65393010877	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
65393010878	active site
65393010879	catalytic tetrad [active]
65393010880	recombinase A; Provisional; Region: recA; PRK09354
65393010881	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
65393010882	hexamer interface [polypeptide binding]; other site
65393010883	Walker A motif; other site
65393010884	ATP binding site [chemical binding]; other site
65393010885	Walker B motif; other site
65393010886	AAA domain; Region: AAA_21; pfam13304
65393010887	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
65393010888	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
65393010889	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
65393010890	TrkA-N domain; Region: TrkA_N; pfam02254
65393010891	ZIP Zinc transporter; Region: Zip; pfam02535
65393010892	Predicted membrane protein [Function unknown]; Region: COG4270
65393010893	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
65393010894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393010895	active site
65393010896	phosphorylation site [posttranslational modification]
65393010897	intermolecular recognition site; other site
65393010898	PAS fold; Region: PAS_3; pfam08447
65393010899	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393010900	putative active site [active]
65393010901	heme pocket [chemical binding]; other site
65393010902	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393010903	GAF domain; Region: GAF_3; pfam13492
65393010904	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393010905	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393010906	metal binding site [ion binding]; metal-binding site
65393010907	active site
65393010908	I-site; other site
65393010909	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
65393010910	putative homodimer interface [polypeptide binding]; other site
65393010911	putative homotetramer interface [polypeptide binding]; other site
65393010912	putative metal binding site [ion binding]; other site
65393010913	putative homodimer-homodimer interface [polypeptide binding]; other site
65393010914	putative allosteric switch controlling residues; other site
65393010915	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
65393010916	phosphoglucomutase; Validated; Region: PRK07564
65393010917	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
65393010918	active site
65393010919	substrate binding site [chemical binding]; other site
65393010920	metal binding site [ion binding]; metal-binding site
65393010921	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010922	Tetratricopeptide repeat; Region: TPR_10; pfam13374
65393010923	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010924	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393010925	binding surface
65393010926	TPR motif; other site
65393010927	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010928	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010929	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393010930	Tetratricopeptide repeat; Region: TPR_10; cl17452
65393010931	Tetratricopeptide repeat; Region: TPR_10; pfam13374
65393010932	CHAT domain; Region: CHAT; pfam12770
65393010933	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
65393010934	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
65393010935	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
65393010936	Protein of unknown function (DUF2283); Region: DUF2283; cl02251
65393010937	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
65393010938	toxin interface [polypeptide binding]; other site
65393010939	Zn binding site [ion binding]; other site
65393010940	HsdM N-terminal domain; Region: HsdM_N; pfam12161
65393010941	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
65393010942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393010943	S-adenosylmethionine binding site [chemical binding]; other site
65393010944	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65393010945	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
65393010946	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
65393010947	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
65393010948	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
65393010949	Transcriptional regulator; Region: Rrf2; pfam02082
65393010950	Predicted transcriptional regulator [Transcription]; Region: COG1959
65393010951	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
65393010952	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
65393010953	hinge; other site
65393010954	active site
65393010955	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
65393010956	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393010957	Walker A motif; other site
65393010958	ATP binding site [chemical binding]; other site
65393010959	Walker B motif; other site
65393010960	arginine finger; other site
65393010961	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
65393010962	protein-splicing catalytic site; other site
65393010963	thioester formation/cholesterol transfer; other site
65393010964	Pretoxin HINT domain; Region: PT-HINT; pfam07591
65393010965	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
65393010966	GIY-YIG motif/motif A; other site
65393010967	active site
65393010968	catalytic site [active]
65393010969	metal binding site [ion binding]; metal-binding site
65393010970	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
65393010971	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
65393010972	Cupin domain; Region: Cupin_2; cl17218
65393010973	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
65393010974	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65393010975	active site
65393010976	metal binding site [ion binding]; metal-binding site
65393010977	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
65393010978	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
65393010979	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
65393010980	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
65393010981	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
65393010982	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
65393010983	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
65393010984	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
65393010985	catalytic loop [active]
65393010986	iron binding site [ion binding]; other site
65393010987	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
65393010988	4Fe-4S binding domain; Region: Fer4; pfam00037
65393010989	hybrid cluster protein; Provisional; Region: PRK05290
65393010990	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65393010991	ACS interaction site; other site
65393010992	CODH interaction site; other site
65393010993	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65393010994	ACS interaction site; other site
65393010995	CODH interaction site; other site
65393010996	metal cluster binding site [ion binding]; other site
65393010997	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
65393010998	dimer interface [polypeptide binding]; other site
65393010999	[2Fe-2S] cluster binding site [ion binding]; other site
65393011000	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
65393011001	SLBB domain; Region: SLBB; pfam10531
65393011002	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
65393011003	bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571
65393011004	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
65393011005	putative dimer interface [polypeptide binding]; other site
65393011006	[2Fe-2S] cluster binding site [ion binding]; other site
65393011007	Restriction endonuclease NotI; Region: NotI; pfam12183
65393011008	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65393011009	DNA methylase; Region: N6_N4_Mtase; pfam01555
65393011010	DNA methylase; Region: N6_N4_Mtase; pfam01555
65393011011	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65393011012	pantothenate kinase; Reviewed; Region: PRK13331
65393011013	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393011014	Major Facilitator Superfamily; Region: MFS_1; pfam07690
65393011015	putative substrate translocation pore; other site
65393011016	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
65393011017	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
65393011018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393011019	dimer interface [polypeptide binding]; other site
65393011020	ABC-ATPase subunit interface; other site
65393011021	putative PBP binding loops; other site
65393011022	Domain of unknown function (DUF4209); Region: DUF4209; pfam13910
65393011023	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
65393011024	signal recognition particle protein; Provisional; Region: PRK10867
65393011025	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
65393011026	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
65393011027	P loop; other site
65393011028	GTP binding site [chemical binding]; other site
65393011029	Signal peptide binding domain; Region: SRP_SPB; pfam02978
65393011030	molecular chaperone DnaK; Provisional; Region: PRK13411
65393011031	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
65393011032	nucleotide binding site [chemical binding]; other site
65393011033	NEF interaction site [polypeptide binding]; other site
65393011034	SBD interface [polypeptide binding]; other site
65393011035	GrpE; Region: GrpE; pfam01025
65393011036	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
65393011037	dimer interface [polypeptide binding]; other site
65393011038	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
65393011039	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
65393011040	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
65393011041	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
65393011042	Walker A motif; other site
65393011043	ATP binding site [chemical binding]; other site
65393011044	Walker B motif; other site
65393011045	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
65393011046	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
65393011047	Walker A motif; other site
65393011048	ATP binding site [chemical binding]; other site
65393011049	Walker B motif; other site
65393011050	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
65393011051	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
65393011052	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
65393011053	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393011054	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
65393011055	30S subunit binding site; other site
65393011056	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
65393011057	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65393011058	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393011059	phosphopeptide binding site; other site
65393011060	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
65393011061	cyclase homology domain; Region: CHD; cd07302
65393011062	nucleotidyl binding site; other site
65393011063	metal binding site [ion binding]; metal-binding site
65393011064	dimer interface [polypeptide binding]; other site
65393011065	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
65393011066	Bacitracin resistance protein BacA; Region: BacA; pfam02673
65393011067	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65393011068	DNA methylase; Region: N6_N4_Mtase; pfam01555
65393011069	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
65393011070	G1 box; other site
65393011071	GTP/Mg2+ binding site [chemical binding]; other site
65393011072	G2 box; other site
65393011073	Switch I region; other site
65393011074	Switch II region; other site
65393011075	G4 box; other site
65393011076	Domain of unknown function (DUF697); Region: DUF697; pfam05128
65393011077	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
65393011078	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
65393011079	Probable Catalytic site; other site
65393011080	metal-binding site
65393011081	hypothetical protein; Provisional; Region: PRK07208
65393011082	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393011083	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65393011084	active site
65393011085	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
65393011086	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65393011087	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393011088	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65393011089	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65393011090	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65393011091	active site
65393011092	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393011093	colanic acid exporter; Provisional; Region: PRK10459
65393011094	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
65393011095	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393011096	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393011097	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65393011098	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65393011099	active site
65393011100	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
65393011101	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
65393011102	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65393011103	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
65393011104	DNA repair protein RadA; Provisional; Region: PRK11823
65393011105	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
65393011106	Walker A motif/ATP binding site; other site
65393011107	ATP binding site [chemical binding]; other site
65393011108	Walker B motif; other site
65393011109	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
65393011110	Ycf27; Reviewed; Region: orf27; CHL00148
65393011111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393011112	active site
65393011113	phosphorylation site [posttranslational modification]
65393011114	intermolecular recognition site; other site
65393011115	dimerization interface [polypeptide binding]; other site
65393011116	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393011117	DNA binding site [nucleotide binding]
65393011118	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
65393011119	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
65393011120	putative active site pocket [active]
65393011121	dimerization interface [polypeptide binding]; other site
65393011122	putative catalytic residue [active]
65393011123	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393011124	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393011125	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393011126	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393011127	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393011128	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393011129	dimer interface [polypeptide binding]; other site
65393011130	phosphorylation site [posttranslational modification]
65393011131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393011132	ATP binding site [chemical binding]; other site
65393011133	Mg2+ binding site [ion binding]; other site
65393011134	G-X-G motif; other site
65393011135	NACHT domain; Region: NACHT; pfam05729
65393011136	HEAT repeats; Region: HEAT_2; pfam13646
65393011137	HEAT repeats; Region: HEAT_2; pfam13646
65393011138	HEAT repeats; Region: HEAT_2; pfam13646
65393011139	HEAT repeats; Region: HEAT_2; pfam13646
65393011140	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
65393011141	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65393011142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393011143	Probable transposase; Region: OrfB_IS605; pfam01385
65393011144	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
65393011145	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
65393011146	Helix-turn-helix domain; Region: HTH_25; pfam13413
65393011147	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
65393011148	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
65393011149	RNA/DNA hybrid binding site [nucleotide binding]; other site
65393011150	active site
65393011151	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
65393011152	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
65393011153	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
65393011154	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
65393011155	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
65393011156	XisI protein; Region: XisI; pfam08869
65393011157	Protein of unknown function DUF262; Region: DUF262; pfam03235
65393011158	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393011159	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
65393011160	TrkA-N domain; Region: TrkA_N; pfam02254
65393011161	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
65393011162	TrkA-N domain; Region: TrkA_N; pfam02254
65393011163	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
65393011164	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
65393011165	active site
65393011166	HIGH motif; other site
65393011167	nucleotide binding site [chemical binding]; other site
65393011168	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
65393011169	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
65393011170	active site
65393011171	KMSKS motif; other site
65393011172	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
65393011173	tRNA binding surface [nucleotide binding]; other site
65393011174	anticodon binding site; other site
65393011175	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
65393011176	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65393011177	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
65393011178	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
65393011179	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
65393011180	DNA polymerase I; Provisional; Region: PRK05755
65393011181	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
65393011182	active site
65393011183	metal binding site 1 [ion binding]; metal-binding site
65393011184	putative 5' ssDNA interaction site; other site
65393011185	metal binding site 3; metal-binding site
65393011186	metal binding site 2 [ion binding]; metal-binding site
65393011187	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
65393011188	putative DNA binding site [nucleotide binding]; other site
65393011189	putative metal binding site [ion binding]; other site
65393011190	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
65393011191	active site
65393011192	catalytic site [active]
65393011193	substrate binding site [chemical binding]; other site
65393011194	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
65393011195	active site
65393011196	DNA binding site [nucleotide binding]
65393011197	catalytic site [active]
65393011198	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
65393011199	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
65393011200	active site
65393011201	catalytic site [active]
65393011202	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
65393011203	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
65393011204	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
65393011205	twin arginine translocase protein A; Provisional; Region: tatA; PRK14857
65393011206	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
65393011207	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393011208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393011209	active site
65393011210	phosphorylation site [posttranslational modification]
65393011211	intermolecular recognition site; other site
65393011212	dimerization interface [polypeptide binding]; other site
65393011213	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393011214	DNA binding site [nucleotide binding]
65393011215	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
65393011216	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
65393011217	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
65393011218	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
65393011219	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65393011220	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393011221	homodimer interface [polypeptide binding]; other site
65393011222	catalytic residue [active]
65393011223	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
65393011224	Fasciclin domain; Region: Fasciclin; pfam02469
65393011225	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
65393011226	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
65393011227	NAD binding site [chemical binding]; other site
65393011228	homodimer interface [polypeptide binding]; other site
65393011229	active site
65393011230	substrate binding site [chemical binding]; other site
65393011231	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65393011232	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65393011233	active site
65393011234	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
65393011235	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
65393011236	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
65393011237	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
65393011238	Walker A/P-loop; other site
65393011239	ATP binding site [chemical binding]; other site
65393011240	Q-loop/lid; other site
65393011241	ABC transporter signature motif; other site
65393011242	Walker B; other site
65393011243	D-loop; other site
65393011244	H-loop/switch region; other site
65393011245	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
65393011246	putative carbohydrate binding site [chemical binding]; other site
65393011247	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393011248	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65393011249	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65393011250	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65393011251	active site
65393011252	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65393011253	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65393011254	active site
65393011255	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393011256	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65393011257	Methyltransferase domain; Region: Methyltransf_24; pfam13578
65393011258	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
65393011259	Radical SAM superfamily; Region: Radical_SAM; pfam04055
65393011260	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65393011261	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393011262	S-adenosylmethionine binding site [chemical binding]; other site
65393011263	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
65393011264	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
65393011265	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
65393011266	23S rRNA binding site [nucleotide binding]; other site
65393011267	L21 binding site [polypeptide binding]; other site
65393011268	L13 binding site [polypeptide binding]; other site
65393011269	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
65393011270	PhoH-like protein; Region: PhoH; pfam02562
65393011271	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
65393011272	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
65393011273	[2Fe-2S] cluster binding site [ion binding]; other site
65393011274	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65393011275	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
65393011276	active site
65393011277	metal binding site [ion binding]; metal-binding site
65393011278	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
65393011279	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65393011280	catalytic residues [active]
65393011281	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
65393011282	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65393011283	cofactor binding site; other site
65393011284	DNA binding site [nucleotide binding]
65393011285	substrate interaction site [chemical binding]; other site
65393011286	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65393011287	putative molybdenum utilization protein ModD; Region: modD; TIGR01334
65393011288	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
65393011289	dimerization interface [polypeptide binding]; other site
65393011290	active site
65393011291	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
65393011292	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
65393011293	ligand binding site [chemical binding]; other site
65393011294	homodimer interface [polypeptide binding]; other site
65393011295	NAD(P) binding site [chemical binding]; other site
65393011296	trimer interface B [polypeptide binding]; other site
65393011297	trimer interface A [polypeptide binding]; other site
65393011298	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
65393011299	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
65393011300	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
65393011301	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
65393011302	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
65393011303	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
65393011304	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
65393011305	CoA binding domain; Region: CoA_binding_2; pfam13380
65393011306	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
65393011307	CoA-ligase; Region: Ligase_CoA; pfam00549
65393011308	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
65393011309	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
65393011310	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
65393011311	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
65393011312	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
65393011313	glycogen binding site [chemical binding]; other site
65393011314	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
65393011315	active site
65393011316	catalytic site [active]
65393011317	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
65393011318	FtsH Extracellular; Region: FtsH_ext; pfam06480
65393011319	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
65393011320	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393011321	Walker A motif; other site
65393011322	ATP binding site [chemical binding]; other site
65393011323	Walker B motif; other site
65393011324	arginine finger; other site
65393011325	Peptidase family M41; Region: Peptidase_M41; pfam01434
65393011326	geranylgeranyl reductase; Region: ChlP; TIGR02028
65393011327	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
65393011328	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
65393011329	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
65393011330	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
65393011331	Zn binding site [ion binding]; other site
65393011332	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
65393011333	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
65393011334	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
65393011335	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
65393011336	catalytic triad [active]
65393011337	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
65393011338	Predicted transcriptional regulator [Transcription]; Region: COG3682
65393011339	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
65393011340	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
65393011341	hexamer interface [polypeptide binding]; other site
65393011342	ligand binding site [chemical binding]; other site
65393011343	putative active site [active]
65393011344	NAD(P) binding site [chemical binding]; other site
65393011345	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393011346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393011347	active site
65393011348	phosphorylation site [posttranslational modification]
65393011349	intermolecular recognition site; other site
65393011350	dimerization interface [polypeptide binding]; other site
65393011351	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393011352	DNA binding site [nucleotide binding]
65393011353	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393011354	dimerization interface [polypeptide binding]; other site
65393011355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393011356	dimer interface [polypeptide binding]; other site
65393011357	phosphorylation site [posttranslational modification]
65393011358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393011359	ATP binding site [chemical binding]; other site
65393011360	G-X-G motif; other site
65393011361	TIR domain; Region: TIR_2; pfam13676
65393011362	TIR domain; Region: TIR_2; pfam13676
65393011363	Divergent AAA domain; Region: AAA_4; pfam04326
65393011364	CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766
65393011365	light-harvesting-like protein 3; Provisional; Region: PLN00014
65393011366	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
65393011367	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
65393011368	HIGH motif; other site
65393011369	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
65393011370	active site
65393011371	KMSKS motif; other site
65393011372	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393011373	putative active site [active]
65393011374	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65393011375	DNA methylase; Region: N6_N4_Mtase; pfam01555
65393011376	Restriction endonuclease; Region: Mrr_cat; pfam04471
65393011377	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393011378	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
65393011379	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
65393011380	active site
65393011381	catalytic tetrad [active]
65393011382	Predicted GTPase [General function prediction only]; Region: COG3596
65393011383	YfjP GTPase; Region: YfjP; cd11383
65393011384	G1 box; other site
65393011385	GTP/Mg2+ binding site [chemical binding]; other site
65393011386	Switch I region; other site
65393011387	G2 box; other site
65393011388	Switch II region; other site
65393011389	G3 box; other site
65393011390	G4 box; other site
65393011391	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
65393011392	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
65393011393	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
65393011394	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
65393011395	SLBB domain; Region: SLBB; pfam10531
65393011396	Chain length determinant protein; Region: Wzz; pfam02706
65393011397	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
65393011398	Chain length determinant protein; Region: Wzz; cl15801
65393011399	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
65393011400	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
65393011401	Nucleotide binding site [chemical binding]; other site
65393011402	DTAP/Switch II; other site
65393011403	Switch I; other site
65393011404	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
65393011405	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
65393011406	TPR repeat; Region: TPR_11; pfam13414
65393011407	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393011408	binding surface
65393011409	TPR motif; other site
65393011410	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393011411	PBP superfamily domain; Region: PBP_like_2; pfam12849
65393011412	Mg chelatase-related protein; Region: TIGR00368
65393011413	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
65393011414	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393011415	Walker A motif; other site
65393011416	ATP binding site [chemical binding]; other site
65393011417	Walker B motif; other site
65393011418	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
65393011419	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
65393011420	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
65393011421	RNA binding surface [nucleotide binding]; other site
65393011422	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
65393011423	active site
65393011424	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
65393011425	Helix-turn-helix domain; Region: HTH_25; pfam13413
65393011426	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
65393011427	amidophosphoribosyltransferase; Provisional; Region: PRK07349
65393011428	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
65393011429	active site
65393011430	tetramer interface [polypeptide binding]; other site
65393011431	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65393011432	active site
65393011433	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393011434	putative active site [active]
65393011435	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
65393011436	GIY-YIG motif/motif A; other site
65393011437	active site
65393011438	catalytic site [active]
65393011439	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
65393011440	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
65393011441	dimerization interface [polypeptide binding]; other site
65393011442	ATP binding site [chemical binding]; other site
65393011443	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
65393011444	dimerization interface [polypeptide binding]; other site
65393011445	ATP binding site [chemical binding]; other site
65393011446	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
65393011447	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
65393011448	tetramerization interface [polypeptide binding]; other site
65393011449	active site
65393011450	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393011451	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
65393011452	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393011453	motif II; other site
65393011454	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
65393011455	Uncharacterized conserved protein [Function unknown]; Region: COG3349
65393011456	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393011457	glutathione reductase; Validated; Region: PRK06116
65393011458	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
65393011459	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65393011460	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
65393011461	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
65393011462	Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433
65393011463	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
65393011464	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
65393011465	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
65393011466	putative active site [active]
65393011467	putative NTP binding site [chemical binding]; other site
65393011468	putative nucleic acid binding site [nucleotide binding]; other site
65393011469	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
65393011470	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
65393011471	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
65393011472	active site
65393011473	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
65393011474	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
65393011475	active site
65393011476	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393011477	putative active site [active]
65393011478	Aspartyl protease; Region: Asp_protease_2; pfam13650
65393011479	inhibitor binding site; inhibition site
65393011480	catalytic motif [active]
65393011481	Catalytic residue [active]
65393011482	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
65393011483	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
65393011484	active site
65393011485	homodimer interface [polypeptide binding]; other site
65393011486	catalytic site [active]
65393011487	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
65393011488	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
65393011489	active site
65393011490	SAM binding site [chemical binding]; other site
65393011491	homodimer interface [polypeptide binding]; other site
65393011492	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
65393011493	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
65393011494	Stage II sporulation protein; Region: SpoIID; pfam08486
65393011495	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
65393011496	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65393011497	P-loop; other site
65393011498	Magnesium ion binding site [ion binding]; other site
65393011499	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65393011500	Magnesium ion binding site [ion binding]; other site
65393011501	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
65393011502	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65393011503	active site
65393011504	metal binding site [ion binding]; metal-binding site
65393011505	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
65393011506	active site
65393011507	metal binding site [ion binding]; metal-binding site
65393011508	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393011509	binding surface
65393011510	TPR motif; other site
65393011511	TPR repeat; Region: TPR_11; pfam13414
65393011512	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393011513	binding surface
65393011514	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393011515	TPR motif; other site
65393011516	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393011517	binding surface
65393011518	TPR repeat; Region: TPR_11; pfam13414
65393011519	TPR motif; other site
65393011520	cytochrome c6; Provisional; Region: PRK13697
65393011521	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
65393011522	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
65393011523	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
65393011524	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
65393011525	Peptidase family M48; Region: Peptidase_M48; pfam01435
65393011526	TROVE domain; Region: TROVE; pfam05731
65393011527	heat shock protein HtpX; Provisional; Region: PRK03982
65393011528	Probable transposase; Region: OrfB_IS605; pfam01385
65393011529	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393011530	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
65393011531	glycogen branching enzyme; Provisional; Region: PRK12313
65393011532	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
65393011533	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
65393011534	active site
65393011535	catalytic site [active]
65393011536	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
65393011537	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393011538	binding surface
65393011539	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393011540	TPR motif; other site
65393011541	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65393011542	binding surface
65393011543	TPR repeat; Region: TPR_11; pfam13414
65393011544	TPR motif; other site
65393011545	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65393011546	TPR motif; other site
65393011547	binding surface
65393011548	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
65393011549	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393011550	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393011551	DNA binding residues [nucleotide binding]
65393011552	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
65393011553	XisI protein; Region: XisI; pfam08869
65393011554	XisH protein; Region: XisH; pfam08814
65393011555	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
65393011556	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65393011557	active site
65393011558	NTP binding site [chemical binding]; other site
65393011559	metal binding triad [ion binding]; metal-binding site
65393011560	antibiotic binding site [chemical binding]; other site
65393011561	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393011562	binding surface
65393011563	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393011564	TPR motif; other site
65393011565	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65393011566	binding surface
65393011567	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393011568	TPR motif; other site
65393011569	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393011570	TPR motif; other site
65393011571	binding surface
65393011572	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
65393011573	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393011574	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393011575	DNA binding residues [nucleotide binding]
65393011576	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
65393011577	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
65393011578	metal-binding site [ion binding]
65393011579	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65393011580	Soluble P-type ATPase [General function prediction only]; Region: COG4087
65393011581	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
65393011582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
65393011583	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
65393011584	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
65393011585	homotetramer interface [polypeptide binding]; other site
65393011586	ligand binding site [chemical binding]; other site
65393011587	catalytic site [active]
65393011588	NAD binding site [chemical binding]; other site
65393011589	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
65393011590	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393011591	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65393011592	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
65393011593	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807
65393011594	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
65393011595	Protein of unknown function (DUF433); Region: DUF433; pfam04255
65393011596	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
65393011597	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
65393011598	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
65393011599	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
65393011600	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
65393011601	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
65393011602	Walker A/P-loop; other site
65393011603	ATP binding site [chemical binding]; other site
65393011604	Q-loop/lid; other site
65393011605	ABC transporter signature motif; other site
65393011606	Walker B; other site
65393011607	D-loop; other site
65393011608	H-loop/switch region; other site
65393011609	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
65393011610	Dimer interface [polypeptide binding]; other site
65393011611	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
65393011612	putative hydrophobic ligand binding site [chemical binding]; other site
65393011613	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
65393011614	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
65393011615	Short C-terminal domain; Region: SHOCT; pfam09851
65393011616	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
65393011617	putative GSH binding site [chemical binding]; other site
65393011618	catalytic residues [active]
65393011619	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393011620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393011621	active site
65393011622	phosphorylation site [posttranslational modification]
65393011623	intermolecular recognition site; other site
65393011624	dimerization interface [polypeptide binding]; other site
65393011625	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393011626	DNA binding site [nucleotide binding]
65393011627	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65393011628	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
65393011629	Walker A/P-loop; other site
65393011630	ATP binding site [chemical binding]; other site
65393011631	Q-loop/lid; other site
65393011632	ABC transporter signature motif; other site
65393011633	Walker B; other site
65393011634	D-loop; other site
65393011635	H-loop/switch region; other site
65393011636	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
65393011637	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
65393011638	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
65393011639	chaperone protein DnaJ; Provisional; Region: PRK14298
65393011640	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
65393011641	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
65393011642	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393011643	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393011644	structural tetrad; other site
65393011645	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393011646	structural tetrad; other site
65393011647	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
65393011648	alpha-gamma subunit interface [polypeptide binding]; other site
65393011649	beta-gamma subunit interface [polypeptide binding]; other site
65393011650	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
65393011651	gamma-beta subunit interface [polypeptide binding]; other site
65393011652	alpha-beta subunit interface [polypeptide binding]; other site
65393011653	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65393011654	UreD urease accessory protein; Region: UreD; pfam01774
65393011655	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
65393011656	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727
65393011657	dimer interface [polypeptide binding]; other site
65393011658	catalytic residues [active]
65393011659	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
65393011660	UreF; Region: UreF; pfam01730
65393011661	urease subunit alpha; Reviewed; Region: ureC; PRK13207
65393011662	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
65393011663	subunit interactions [polypeptide binding]; other site
65393011664	active site
65393011665	flap region; other site
65393011666	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
65393011667	Phycobilisome protein; Region: Phycobilisome; cl08227
65393011668	hydrolase, alpha/beta fold family protein; Region: PLN02824
65393011669	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65393011670	Calicivirus coat protein; Region: Calici_coat; pfam00915
65393011671	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
65393011672	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65393011673	active site
65393011674	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
65393011675	active site
65393011676	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
65393011677	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
65393011678	DXD motif; other site
65393011679	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
65393011680	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
65393011681	Walker A/P-loop; other site
65393011682	ATP binding site [chemical binding]; other site
65393011683	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
65393011684	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
65393011685	ABC transporter signature motif; other site
65393011686	Walker B; other site
65393011687	D-loop; other site
65393011688	H-loop/switch region; other site
65393011689	flavodoxin FldA; Validated; Region: PRK09267
65393011690	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65393011691	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393011692	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
65393011693	Walker A/P-loop; other site
65393011694	ATP binding site [chemical binding]; other site
65393011695	Q-loop/lid; other site
65393011696	ABC transporter signature motif; other site
65393011697	Walker B; other site
65393011698	D-loop; other site
65393011699	H-loop/switch region; other site
65393011700	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
65393011701	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
65393011702	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
65393011703	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393011704	motif II; other site
65393011705	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
65393011706	Putative phosphatase (DUF442); Region: DUF442; cl17385
65393011707	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
65393011708	NACHT domain; Region: NACHT; pfam05729
65393011709	Walker A motif; other site
65393011710	ATP binding site [chemical binding]; other site
65393011711	Walker B motif; other site
65393011712	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393011713	putative active site [active]
65393011714	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
65393011715	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393011716	Walker A motif; other site
65393011717	ATP binding site [chemical binding]; other site
65393011718	Walker B motif; other site
65393011719	arginine finger; other site
65393011720	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
65393011721	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65393011722	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65393011723	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
65393011724	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
65393011725	iron-sulfur cluster [ion binding]; other site
65393011726	[2Fe-2S] cluster binding site [ion binding]; other site
65393011727	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
65393011728	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393011729	PAS domain; Region: PAS_9; pfam13426
65393011730	putative active site [active]
65393011731	heme pocket [chemical binding]; other site
65393011732	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393011733	PAS fold; Region: PAS_3; pfam08447
65393011734	putative active site [active]
65393011735	heme pocket [chemical binding]; other site
65393011736	PAS domain S-box; Region: sensory_box; TIGR00229
65393011737	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393011738	putative active site [active]
65393011739	heme pocket [chemical binding]; other site
65393011740	PAS fold; Region: PAS_4; pfam08448
65393011741	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393011742	putative active site [active]
65393011743	heme pocket [chemical binding]; other site
65393011744	PAS domain S-box; Region: sensory_box; TIGR00229
65393011745	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393011746	putative active site [active]
65393011747	heme pocket [chemical binding]; other site
65393011748	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393011749	PAS domain; Region: PAS_9; pfam13426
65393011750	putative active site [active]
65393011751	heme pocket [chemical binding]; other site
65393011752	PAS domain S-box; Region: sensory_box; TIGR00229
65393011753	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393011754	putative active site [active]
65393011755	heme pocket [chemical binding]; other site
65393011756	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393011757	dimer interface [polypeptide binding]; other site
65393011758	phosphorylation site [posttranslational modification]
65393011759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393011760	ATP binding site [chemical binding]; other site
65393011761	Mg2+ binding site [ion binding]; other site
65393011762	G-X-G motif; other site
65393011763	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
65393011764	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
65393011765	putative NAD(P) binding site [chemical binding]; other site
65393011766	Class I aldolases; Region: Aldolase_Class_I; cl17187
65393011767	catalytic residue [active]
65393011768	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
65393011769	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
65393011770	Walker A/P-loop; other site
65393011771	ATP binding site [chemical binding]; other site
65393011772	Q-loop/lid; other site
65393011773	ABC transporter signature motif; other site
65393011774	Walker B; other site
65393011775	D-loop; other site
65393011776	H-loop/switch region; other site
65393011777	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
65393011778	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
65393011779	Walker A/P-loop; other site
65393011780	ATP binding site [chemical binding]; other site
65393011781	Q-loop/lid; other site
65393011782	ABC transporter signature motif; other site
65393011783	Walker B; other site
65393011784	D-loop; other site
65393011785	H-loop/switch region; other site
65393011786	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
65393011787	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393011788	putative active site [active]
65393011789	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
65393011790	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
65393011791	active site
65393011792	nucleophile elbow; other site
65393011793	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393011794	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65393011795	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65393011796	DNA methylase; Region: N6_N4_Mtase; pfam01555
65393011797	ScaI restriction endonuclease; Region: RE_ScaI; pfam09569
65393011798	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
65393011799	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
65393011800	inhibitor-cofactor binding pocket; inhibition site
65393011801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393011802	catalytic residue [active]
65393011803	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
65393011804	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
65393011805	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
65393011806	Ligand binding site; other site
65393011807	Putative Catalytic site; other site
65393011808	DXD motif; other site
65393011809	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393011810	Probable transposase; Region: OrfB_IS605; pfam01385
65393011811	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393011812	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
65393011813	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
65393011814	putative active site [active]
65393011815	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
65393011816	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393011817	FeS/SAM binding site; other site
65393011818	HemN C-terminal domain; Region: HemN_C; pfam06969
65393011819	glycogen synthase; Provisional; Region: glgA; PRK00654
65393011820	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
65393011821	ADP-binding pocket [chemical binding]; other site
65393011822	homodimer interface [polypeptide binding]; other site
65393011823	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
65393011824	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
65393011825	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
65393011826	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
65393011827	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
65393011828	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
65393011829	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
65393011830	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
65393011831	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
65393011832	classical (c) SDRs; Region: SDR_c; cd05233
65393011833	NAD(P) binding site [chemical binding]; other site
65393011834	active site
65393011835	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
65393011836	intracellular protease, PfpI family; Region: PfpI; TIGR01382
65393011837	proposed catalytic triad [active]
65393011838	conserved cys residue [active]
65393011839	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
65393011840	photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877
65393011841	photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704
65393011842	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
65393011843	RuvA N terminal domain; Region: RuvA_N; pfam01330
65393011844	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
65393011845	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
65393011846	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
65393011847	active site
65393011848	motif I; other site
65393011849	motif II; other site
65393011850	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
65393011851	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
65393011852	S-adenosylmethionine binding site [chemical binding]; other site
65393011853	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
65393011854	RES domain; Region: RES; pfam08808
65393011855	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
65393011856	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
65393011857	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
65393011858	Ligand Binding Site [chemical binding]; other site
65393011859	GTPase Era; Reviewed; Region: era; PRK00089
65393011860	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
65393011861	G1 box; other site
65393011862	GTP/Mg2+ binding site [chemical binding]; other site
65393011863	Switch I region; other site
65393011864	G2 box; other site
65393011865	Switch II region; other site
65393011866	G3 box; other site
65393011867	G4 box; other site
65393011868	G5 box; other site
65393011869	KH domain; Region: KH_2; pfam07650
65393011870	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393011871	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65393011872	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393011873	Walker A/P-loop; other site
65393011874	ATP binding site [chemical binding]; other site
65393011875	Q-loop/lid; other site
65393011876	ABC transporter signature motif; other site
65393011877	Walker B; other site
65393011878	D-loop; other site
65393011879	H-loop/switch region; other site
65393011880	CsbD-like; Region: CsbD; cl17424
65393011881	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
65393011882	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
65393011883	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
65393011884	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
65393011885	putative active site [active]
65393011886	catalytic residue [active]
65393011887	PRC-barrel domain; Region: PRC; pfam05239
65393011888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
65393011889	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
65393011890	nickel binding site [ion binding]; other site
65393011891	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
65393011892	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
65393011893	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
65393011894	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
65393011895	putative active site [active]
65393011896	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
65393011897	putative active site [active]
65393011898	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
65393011899	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65393011900	TPR motif; other site
65393011901	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393011902	binding surface
65393011903	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393011904	binding surface
65393011905	TPR motif; other site
65393011906	TPR repeat; Region: TPR_11; pfam13414
65393011907	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
65393011908	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
65393011909	FtsX-like permease family; Region: FtsX; pfam02687
65393011910	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
65393011911	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
65393011912	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
65393011913	Surface antigen; Region: Bac_surface_Ag; pfam01103
65393011914	Transcriptional regulator PadR-like family; Region: PadR; cl17335
65393011915	Predicted transcriptional regulators [Transcription]; Region: COG1695
65393011916	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393011917	putative active site [active]
65393011918	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
65393011919	Repair protein; Region: Repair_PSII; pfam04536
65393011920	precorrin-8X methylmutase; Validated; Region: PRK05953
65393011921	Precorrin-8X methylmutase; Region: CbiC; pfam02570
65393011922	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393011923	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393011924	Probable transposase; Region: OrfB_IS605; pfam01385
65393011925	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393011926	Protein kinase domain; Region: Pkinase; pfam00069
65393011927	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393011928	active site
65393011929	ATP binding site [chemical binding]; other site
65393011930	substrate binding site [chemical binding]; other site
65393011931	activation loop (A-loop); other site
65393011932	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65393011933	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393011934	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393011935	Uncharacterized protein family UPF0546; Region: UPF0546; pfam10639
65393011936	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
65393011937	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
65393011938	putative NAD(P) binding site [chemical binding]; other site
65393011939	putative active site [active]
65393011940	Psb28 protein; Region: Psb28; pfam03912
65393011941	PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041
65393011942	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
65393011943	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
65393011944	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
65393011945	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
65393011946	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
65393011947	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
65393011948	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
65393011949	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
65393011950	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65393011951	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
65393011952	dimer interface [polypeptide binding]; other site
65393011953	active site
65393011954	Schiff base residues; other site
65393011955	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393011956	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393011957	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393011958	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
65393011959	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
65393011960	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393011961	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65393011962	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393011963	DNA binding residues [nucleotide binding]
65393011964	Protein of unknown function (DUF760); Region: DUF760; pfam05542
65393011965	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
65393011966	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
65393011967	minor groove reading motif; other site
65393011968	helix-hairpin-helix signature motif; other site
65393011969	substrate binding pocket [chemical binding]; other site
65393011970	active site
65393011971	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
65393011972	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
65393011973	active site
65393011974	8-oxo-dGMP binding site [chemical binding]; other site
65393011975	nudix motif; other site
65393011976	metal binding site [ion binding]; metal-binding site
65393011977	chromosome segregation protein; Provisional; Region: PRK03918
65393011978	Hemerythrin-like domain; Region: Hr-like; cd12108
65393011979	Fe binding site [ion binding]; other site
65393011980	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
65393011981	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
65393011982	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
65393011983	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
65393011984	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
65393011985	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
65393011986	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
65393011987	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
65393011988	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
65393011989	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
65393011990	Active Sites [active]
65393011991	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65393011992	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
65393011993	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
65393011994	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
65393011995	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
65393011996	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393011997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393011998	active site
65393011999	phosphorylation site [posttranslational modification]
65393012000	intermolecular recognition site; other site
65393012001	dimerization interface [polypeptide binding]; other site
65393012002	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393012003	DNA binding site [nucleotide binding]
65393012004	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65393012005	putative binding surface; other site
65393012006	active site
65393012007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393012008	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393012009	active site
65393012010	phosphorylation site [posttranslational modification]
65393012011	intermolecular recognition site; other site
65393012012	dimerization interface [polypeptide binding]; other site
65393012013	Response regulator receiver domain; Region: Response_reg; pfam00072
65393012014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393012015	active site
65393012016	phosphorylation site [posttranslational modification]
65393012017	intermolecular recognition site; other site
65393012018	dimerization interface [polypeptide binding]; other site
65393012019	CHASE3 domain; Region: CHASE3; pfam05227
65393012020	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393012021	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393012022	putative active site [active]
65393012023	heme pocket [chemical binding]; other site
65393012024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393012025	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393012026	putative active site [active]
65393012027	heme pocket [chemical binding]; other site
65393012028	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393012029	putative active site [active]
65393012030	heme pocket [chemical binding]; other site
65393012031	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
65393012032	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393012033	putative active site [active]
65393012034	heme pocket [chemical binding]; other site
65393012035	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393012036	dimer interface [polypeptide binding]; other site
65393012037	phosphorylation site [posttranslational modification]
65393012038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393012039	ATP binding site [chemical binding]; other site
65393012040	Mg2+ binding site [ion binding]; other site
65393012041	G-X-G motif; other site
65393012042	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393012043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393012044	active site
65393012045	phosphorylation site [posttranslational modification]
65393012046	intermolecular recognition site; other site
65393012047	dimerization interface [polypeptide binding]; other site
65393012048	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
65393012049	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
65393012050	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
65393012051	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
65393012052	PsaD; Region: PsaD; pfam02531
65393012053	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
65393012054	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
65393012055	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
65393012056	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393012057	Walker A motif; other site
65393012058	ATP binding site [chemical binding]; other site
65393012059	Walker B motif; other site
65393012060	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
65393012061	RxxxH motif; other site
65393012062	WAHD domain of WASH complex; Region: WASH_WAHD; pfam11945
65393012063	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
65393012064	plastocyanin; Provisional; Region: PRK02710
65393012065	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
65393012066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393012067	Walker A/P-loop; other site
65393012068	ATP binding site [chemical binding]; other site
65393012069	Q-loop/lid; other site
65393012070	exonuclease SbcC; Region: sbcc; TIGR00618
65393012071	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
65393012072	ABC transporter signature motif; other site
65393012073	Walker B; other site
65393012074	D-loop; other site
65393012075	H-loop/switch region; other site
65393012076	hypothetical protein; Provisional; Region: PRK07236
65393012077	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
65393012078	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
65393012079	FOG: CBS domain [General function prediction only]; Region: COG0517
65393012080	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65393012081	PAS domain S-box; Region: sensory_box; TIGR00229
65393012082	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393012083	putative active site [active]
65393012084	heme pocket [chemical binding]; other site
65393012085	PAS fold; Region: PAS_4; pfam08448
65393012086	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393012087	putative active site [active]
65393012088	heme pocket [chemical binding]; other site
65393012089	PAS domain S-box; Region: sensory_box; TIGR00229
65393012090	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393012091	putative active site [active]
65393012092	heme pocket [chemical binding]; other site
65393012093	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
65393012094	Histidine kinase; Region: HisKA_2; pfam07568
65393012095	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393012096	ATP binding site [chemical binding]; other site
65393012097	Mg2+ binding site [ion binding]; other site
65393012098	G-X-G motif; other site
65393012099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393012100	active site
65393012101	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393012102	phosphorylation site [posttranslational modification]
65393012103	intermolecular recognition site; other site
65393012104	dimerization interface [polypeptide binding]; other site
65393012105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393012106	dimer interface [polypeptide binding]; other site
65393012107	phosphorylation site [posttranslational modification]
65393012108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393012109	ATP binding site [chemical binding]; other site
65393012110	Mg2+ binding site [ion binding]; other site
65393012111	G-X-G motif; other site
65393012112	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
65393012113	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
65393012114	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
65393012115	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
65393012116	TPP-binding site; other site
65393012117	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
65393012118	PYR/PP interface [polypeptide binding]; other site
65393012119	dimer interface [polypeptide binding]; other site
65393012120	TPP binding site [chemical binding]; other site
65393012121	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
65393012122	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
65393012123	Permease; Region: Permease; cl00510
65393012124	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
65393012125	mce related protein; Region: MCE; pfam02470
65393012126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
65393012127	putative substrate translocation pore; other site
65393012128	phosphate:H+ symporter; Region: 2A0109; TIGR00887
65393012129	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
65393012130	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
65393012131	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
65393012132	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
65393012133	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
65393012134	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
65393012135	anti sigma factor interaction site; other site
65393012136	regulatory phosphorylation site [posttranslational modification]; other site
65393012137	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
65393012138	Bacterial sugar transferase; Region: Bac_transf; pfam02397
65393012139	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65393012140	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65393012141	active site
65393012142	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65393012143	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65393012144	active site
65393012145	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393012146	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
65393012147	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393012148	Walker A/P-loop; other site
65393012149	ATP binding site [chemical binding]; other site
65393012150	Q-loop/lid; other site
65393012151	ABC transporter signature motif; other site
65393012152	Walker B; other site
65393012153	D-loop; other site
65393012154	H-loop/switch region; other site
65393012155	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
65393012156	Glutamine amidotransferase class-I; Region: GATase; pfam00117
65393012157	glutamine binding [chemical binding]; other site
65393012158	catalytic triad [active]
65393012159	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
65393012160	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
65393012161	chorismate binding enzyme; Region: Chorismate_bind; cl10555
65393012162	Chorismate mutase type II; Region: CM_2; cl00693
65393012163	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
65393012164	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
65393012165	prephenate dehydrogenase; Validated; Region: PRK08507
65393012166	Family description; Region: VCBS; pfam13517
65393012167	Family description; Region: VCBS; pfam13517
65393012168	Family description; Region: VCBS; pfam13517
65393012169	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
65393012170	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
65393012171	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
65393012172	trimer interface [polypeptide binding]; other site
65393012173	active site
65393012174	substrate binding site [chemical binding]; other site
65393012175	CoA binding site [chemical binding]; other site
65393012176	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65393012177	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393012178	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65393012179	Uncharacterized conserved protein [Function unknown]; Region: COG3379
65393012180	Uncharacterized conserved protein [Function unknown]; Region: COG3379
65393012181	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
65393012182	putative metal binding site [ion binding]; other site
65393012183	Uncharacterized conserved protein [Function unknown]; Region: COG3379
65393012184	Uncharacterized conserved protein [Function unknown]; Region: COG3379
65393012185	Uncharacterized conserved protein [Function unknown]; Region: COG3379
65393012186	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
65393012187	Chain length determinant protein; Region: Wzz; cl15801
65393012188	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
65393012189	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65393012190	active site
65393012191	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
65393012192	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
65393012193	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
65393012194	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
65393012195	SLBB domain; Region: SLBB; pfam10531
65393012196	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
65393012197	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
65393012198	putative binding surface; other site
65393012199	active site
65393012200	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
65393012201	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393012202	ATP binding site [chemical binding]; other site
65393012203	Mg2+ binding site [ion binding]; other site
65393012204	G-X-G motif; other site
65393012205	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
65393012206	Response regulator receiver domain; Region: Response_reg; pfam00072
65393012207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393012208	active site
65393012209	phosphorylation site [posttranslational modification]
65393012210	intermolecular recognition site; other site
65393012211	dimerization interface [polypeptide binding]; other site
65393012212	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393012213	dimerization interface [polypeptide binding]; other site
65393012214	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65393012215	dimer interface [polypeptide binding]; other site
65393012216	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
65393012217	putative CheW interface [polypeptide binding]; other site
65393012218	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
65393012219	Response regulator receiver domain; Region: Response_reg; pfam00072
65393012220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393012221	active site
65393012222	phosphorylation site [posttranslational modification]
65393012223	intermolecular recognition site; other site
65393012224	dimerization interface [polypeptide binding]; other site
65393012225	Response regulator receiver domain; Region: Response_reg; pfam00072
65393012226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393012227	active site
65393012228	phosphorylation site [posttranslational modification]
65393012229	intermolecular recognition site; other site
65393012230	dimerization interface [polypeptide binding]; other site
65393012231	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
65393012232	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
65393012233	homotetramer interface [polypeptide binding]; other site
65393012234	FMN binding site [chemical binding]; other site
65393012235	homodimer contacts [polypeptide binding]; other site
65393012236	putative active site [active]
65393012237	putative substrate binding site [chemical binding]; other site
65393012238	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
65393012239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393012240	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393012241	Probable transposase; Region: OrfB_IS605; pfam01385
65393012242	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393012243	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
65393012244	RNB domain; Region: RNB; pfam00773
65393012245	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
65393012246	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
65393012247	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
65393012248	TrkA-N domain; Region: TrkA_N; pfam02254
65393012249	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
65393012250	GIY-YIG motif/motif A; other site
65393012251	TIR domain; Region: TIR_2; pfam13676
65393012252	GUN4-like; Region: GUN4; pfam05419
65393012253	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
65393012254	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
65393012255	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
65393012256	CHASE2 domain; Region: CHASE2; pfam05226
65393012257	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393012258	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393012259	active site
65393012260	ATP binding site [chemical binding]; other site
65393012261	substrate binding site [chemical binding]; other site
65393012262	activation loop (A-loop); other site
65393012263	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
65393012264	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
65393012265	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
65393012266	active site
65393012267	catalytic site [active]
65393012268	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
65393012269	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
65393012270	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
65393012271	catalytic site [active]
65393012272	active site
65393012273	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
65393012274	trehalose synthase; Region: treS_nterm; TIGR02456
65393012275	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
65393012276	active site
65393012277	catalytic site [active]
65393012278	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467
65393012279	starch-binding site 2 [chemical binding]; other site
65393012280	starch-binding site 1 [chemical binding]; other site
65393012281	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
65393012282	S-layer homology domain; Region: SLH; pfam00395
65393012283	S-layer homology domain; Region: SLH; pfam00395
65393012284	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
65393012285	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
65393012286	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393012287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393012288	active site
65393012289	phosphorylation site [posttranslational modification]
65393012290	intermolecular recognition site; other site
65393012291	dimerization interface [polypeptide binding]; other site
65393012292	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393012293	DNA binding site [nucleotide binding]
65393012294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393012295	dimer interface [polypeptide binding]; other site
65393012296	phosphorylation site [posttranslational modification]
65393012297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393012298	ATP binding site [chemical binding]; other site
65393012299	Mg2+ binding site [ion binding]; other site
65393012300	G-X-G motif; other site
65393012301	Rubrerythrin [Energy production and conversion]; Region: COG1592
65393012302	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
65393012303	binuclear metal center [ion binding]; other site
65393012304	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
65393012305	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
65393012306	iron-sulfur cluster [ion binding]; other site
65393012307	[2Fe-2S] cluster binding site [ion binding]; other site
65393012308	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
65393012309	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
65393012310	dimer interface [polypeptide binding]; other site
65393012311	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393012312	catalytic residue [active]
65393012313	Ycf46; Provisional; Region: ycf46; CHL00195
65393012314	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393012315	Walker A motif; other site
65393012316	ATP binding site [chemical binding]; other site
65393012317	Walker B motif; other site
65393012318	arginine finger; other site
65393012319	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
65393012320	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
65393012321	classical (c) SDRs; Region: SDR_c; cd05233
65393012322	NAD(P) binding site [chemical binding]; other site
65393012323	active site
65393012324	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
65393012325	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
65393012326	active site
65393012327	FMN binding site [chemical binding]; other site
65393012328	substrate binding site [chemical binding]; other site
65393012329	putative catalytic residue [active]
65393012330	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
65393012331	phosphate binding site [ion binding]; other site
65393012332	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
65393012333	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
65393012334	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
65393012335	active site
65393012336	nucleophile elbow; other site
65393012337	YcfA-like protein; Region: YcfA; pfam07927
65393012338	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65393012339	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393012340	Probable transposase; Region: OrfB_IS605; pfam01385
65393012341	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393012342	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
65393012343	catalytic core [active]
65393012344	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
65393012345	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
65393012346	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
65393012347	tartrate dehydrogenase; Region: TTC; TIGR02089
65393012348	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
65393012349	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
65393012350	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
65393012351	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
65393012352	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
65393012353	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
65393012354	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
65393012355	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
65393012356	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
65393012357	dimer interface [polypeptide binding]; other site
65393012358	motif 1; other site
65393012359	active site
65393012360	motif 2; other site
65393012361	motif 3; other site
65393012362	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
65393012363	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393012364	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
65393012365	active site
65393012366	SAM binding site [chemical binding]; other site
65393012367	homodimer interface [polypeptide binding]; other site
65393012368	PilZ domain; Region: PilZ; pfam07238
65393012369	DNA gyrase subunit A; Validated; Region: PRK05560
65393012370	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
65393012371	CAP-like domain; other site
65393012372	active site
65393012373	primary dimer interface [polypeptide binding]; other site
65393012374	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65393012375	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65393012376	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65393012377	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65393012378	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65393012379	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
65393012380	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
65393012381	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
65393012382	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393012383	Walker A/P-loop; other site
65393012384	ATP binding site [chemical binding]; other site
65393012385	Q-loop/lid; other site
65393012386	ABC transporter signature motif; other site
65393012387	Walker B; other site
65393012388	D-loop; other site
65393012389	H-loop/switch region; other site
65393012390	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
65393012391	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
65393012392	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
65393012393	NTP binding site [chemical binding]; other site
65393012394	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
65393012395	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
65393012396	Walker A/P-loop; other site
65393012397	ATP binding site [chemical binding]; other site
65393012398	Q-loop/lid; other site
65393012399	ABC transporter signature motif; other site
65393012400	Walker B; other site
65393012401	D-loop; other site
65393012402	H-loop/switch region; other site
65393012403	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
65393012404	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
65393012405	Walker A/P-loop; other site
65393012406	ATP binding site [chemical binding]; other site
65393012407	Q-loop/lid; other site
65393012408	ABC transporter signature motif; other site
65393012409	Walker B; other site
65393012410	D-loop; other site
65393012411	H-loop/switch region; other site
65393012412	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
65393012413	NMT1-like family; Region: NMT1_2; pfam13379
65393012414	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
65393012415	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393012416	dimer interface [polypeptide binding]; other site
65393012417	conserved gate region; other site
65393012418	putative PBP binding loops; other site
65393012419	ABC-ATPase subunit interface; other site
65393012420	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
65393012421	NMT1-like family; Region: NMT1_2; pfam13379
65393012422	Methyltransferase domain; Region: Methyltransf_31; pfam13847
65393012423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393012424	S-adenosylmethionine binding site [chemical binding]; other site
65393012425	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
65393012426	active site
65393012427	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393012428	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393012429	active site
65393012430	ATP binding site [chemical binding]; other site
65393012431	substrate binding site [chemical binding]; other site
65393012432	activation loop (A-loop); other site
65393012433	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
65393012434	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
65393012435	putative ligand binding site [chemical binding]; other site
65393012436	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
65393012437	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
65393012438	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
65393012439	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
65393012440	AAA domain; Region: AAA_26; pfam13500
65393012441	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
65393012442	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
65393012443	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65393012444	active site
65393012445	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
65393012446	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
65393012447	Catalytic site [active]
65393012448	dihydroorotase; Provisional; Region: PRK07575
65393012449	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
65393012450	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
65393012451	active site
65393012452	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
65393012453	putative active site pocket [active]
65393012454	dimerization interface [polypeptide binding]; other site
65393012455	putative catalytic residue [active]
65393012456	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
65393012457	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
65393012458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393012459	ATP binding site [chemical binding]; other site
65393012460	Mg2+ binding site [ion binding]; other site
65393012461	G-X-G motif; other site
65393012462	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
65393012463	Response regulator receiver domain; Region: Response_reg; pfam00072
65393012464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393012465	active site
65393012466	phosphorylation site [posttranslational modification]
65393012467	intermolecular recognition site; other site
65393012468	dimerization interface [polypeptide binding]; other site
65393012469	Response regulator receiver domain; Region: Response_reg; pfam00072
65393012470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393012471	active site
65393012472	phosphorylation site [posttranslational modification]
65393012473	intermolecular recognition site; other site
65393012474	dimerization interface [polypeptide binding]; other site
65393012475	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
65393012476	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
65393012477	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393012478	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
65393012479	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
65393012480	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
65393012481	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
65393012482	conserved cys residue [active]
65393012483	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
65393012484	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
65393012485	PYR/PP interface [polypeptide binding]; other site
65393012486	dimer interface [polypeptide binding]; other site
65393012487	TPP binding site [chemical binding]; other site
65393012488	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
65393012489	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
65393012490	TPP-binding site [chemical binding]; other site
65393012491	dimer interface [polypeptide binding]; other site
65393012492	S-layer homology domain; Region: SLH; pfam00395
65393012493	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
65393012494	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
65393012495	choline dehydrogenase; Validated; Region: PRK02106
65393012496	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
65393012497	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
65393012498	lycopene cyclase; Region: lycopene_cycl; TIGR01789
65393012499	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
65393012500	EthD domain; Region: EthD; pfam07110
65393012501	EthD domain; Region: EthD; pfam07110
65393012502	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
65393012503	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
65393012504	SnoaL-like domain; Region: SnoaL_2; pfam12680
65393012505	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65393012506	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
65393012507	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
65393012508	dimerization interface [polypeptide binding]; other site
65393012509	putative active cleft [active]
65393012510	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
65393012511	anti sigma factor interaction site; other site
65393012512	regulatory phosphorylation site [posttranslational modification]; other site
65393012513	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
65393012514	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
65393012515	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
65393012516	catalytic site [active]
65393012517	active site
65393012518	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
65393012519	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315
65393012520	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
65393012521	active site
65393012522	Ca binding site [ion binding]; other site
65393012523	catalytic site [active]
65393012524	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
65393012525	homotrimer interaction site [polypeptide binding]; other site
65393012526	putative active site [active]
65393012527	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
65393012528	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
65393012529	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
65393012530	Ligand Binding Site [chemical binding]; other site
65393012531	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
65393012532	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
65393012533	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
65393012534	Ligand Binding Site [chemical binding]; other site
65393012535	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393012536	Ligand Binding Site [chemical binding]; other site
65393012537	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
65393012538	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
65393012539	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
65393012540	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
65393012541	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
65393012542	Sulfate transporter family; Region: Sulfate_transp; pfam00916
65393012543	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
65393012544	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393012545	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393012546	active site
65393012547	ATP binding site [chemical binding]; other site
65393012548	substrate binding site [chemical binding]; other site
65393012549	activation loop (A-loop); other site
65393012550	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393012551	binding surface
65393012552	TPR motif; other site
65393012553	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
65393012554	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393012555	binding surface
65393012556	TPR motif; other site
65393012557	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393012558	binding surface
65393012559	TPR motif; other site
65393012560	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393012561	binding surface
65393012562	TPR motif; other site
65393012563	TPR repeat; Region: TPR_11; pfam13414
65393012564	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393012565	binding surface
65393012566	TPR motif; other site
65393012567	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
65393012568	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
65393012569	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
65393012570	Zn2+ binding site [ion binding]; other site
65393012571	Mg2+ binding site [ion binding]; other site
65393012572	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
65393012573	putative ABC transporter; Region: ycf24; CHL00085
65393012574	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
65393012575	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
65393012576	Walker A/P-loop; other site
65393012577	ATP binding site [chemical binding]; other site
65393012578	Q-loop/lid; other site
65393012579	ABC transporter signature motif; other site
65393012580	Walker B; other site
65393012581	D-loop; other site
65393012582	H-loop/switch region; other site
65393012583	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
65393012584	FeS assembly protein SufD; Region: sufD; TIGR01981
65393012585	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
65393012586	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
65393012587	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
65393012588	catalytic residue [active]
65393012589	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393012590	Uncharacterized conserved protein [Function unknown]; Region: COG3379
65393012591	Uncharacterized conserved protein [Function unknown]; Region: COG3379
65393012592	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393012593	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393012594	EamA-like transporter family; Region: EamA; pfam00892
65393012595	EamA-like transporter family; Region: EamA; pfam00892
65393012596	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
65393012597	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
65393012598	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393012599	binding surface
65393012600	TPR motif; other site
65393012601	TPR repeat; Region: TPR_11; pfam13414
65393012602	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393012603	putative active site [active]
65393012604	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
65393012605	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
65393012606	GDP-binding site [chemical binding]; other site
65393012607	ACT binding site; other site
65393012608	IMP binding site; other site
65393012609	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
65393012610	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
65393012611	5S rRNA interface [nucleotide binding]; other site
65393012612	CTC domain interface [polypeptide binding]; other site
65393012613	L16 interface [polypeptide binding]; other site
65393012614	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
65393012615	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
65393012616	putative NAD(P) binding site [chemical binding]; other site
65393012617	Uncharacterized conserved protein [Function unknown]; Region: COG1262
65393012618	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
65393012619	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
65393012620	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
65393012621	ABC-ATPase subunit  interface; other site
65393012622	dimer interface [polypeptide binding]; other site
65393012623	putative PBP binding regions; other site
65393012624	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
65393012625	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
65393012626	substrate binding site [chemical binding]; other site
65393012627	active site
65393012628	catalytic residues [active]
65393012629	heterodimer interface [polypeptide binding]; other site
65393012630	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
65393012631	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
65393012632	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
65393012633	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65393012634	active site
65393012635	metal binding site [ion binding]; metal-binding site
65393012636	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
65393012637	active site
65393012638	Zn2+ binding site [ion binding]; other site
65393012639	fibro-slime domain; Region: Fibro_Slime; TIGR02148
65393012640	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
65393012641	chorismate binding enzyme; Region: Chorismate_bind; cl10555
65393012642	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
65393012643	UbiA prenyltransferase family; Region: UbiA; pfam01040
65393012644	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
65393012645	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
65393012646	active site
65393012647	putative lithium-binding site [ion binding]; other site
65393012648	substrate binding site [chemical binding]; other site
65393012649	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
65393012650	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
65393012651	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
65393012652	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
65393012653	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
65393012654	putative tRNA-binding site [nucleotide binding]; other site
65393012655	B3/4 domain; Region: B3_4; pfam03483
65393012656	tRNA synthetase B5 domain; Region: B5; smart00874
65393012657	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
65393012658	dimer interface [polypeptide binding]; other site
65393012659	motif 1; other site
65393012660	motif 3; other site
65393012661	motif 2; other site
65393012662	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
65393012663	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393012664	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393012665	putative active site [active]
65393012666	glycine dehydrogenase; Provisional; Region: PRK05367
65393012667	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
65393012668	tetramer interface [polypeptide binding]; other site
65393012669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393012670	catalytic residue [active]
65393012671	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
65393012672	tetramer interface [polypeptide binding]; other site
65393012673	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393012674	catalytic residue [active]
65393012675	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393012676	putative active site [active]
65393012677	Protein-arginine deiminase (PAD) middle domain; Region: PAD_M; pfam08527
65393012678	Protein-arginine deiminase (PAD); Region: PAD; pfam03068
65393012679	AAA domain; Region: AAA_22; pfam13401
65393012680	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
65393012681	GUN4-like; Region: GUN4; pfam05419
65393012682	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
65393012683	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
65393012684	Transglutaminase/protease-like homologues; Region: TGc; smart00460
65393012685	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
65393012686	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
65393012687	Uncharacterized conserved protein [Function unknown]; Region: COG2308
65393012688	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393012689	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393012690	Probable transposase; Region: OrfB_IS605; pfam01385
65393012691	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393012692	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
65393012693	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
65393012694	RNA binding surface [nucleotide binding]; other site
65393012695	hypothetical protein; Reviewed; Region: PRK12275
65393012696	four helix bundle protein; Region: TIGR02436
65393012697	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65393012698	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
65393012699	DXD motif; other site
65393012700	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
65393012701	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
65393012702	ligand binding site [chemical binding]; other site
65393012703	NAD binding site [chemical binding]; other site
65393012704	dimerization interface [polypeptide binding]; other site
65393012705	catalytic site [active]
65393012706	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
65393012707	putative L-serine binding site [chemical binding]; other site
65393012708	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
65393012709	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
65393012710	active site
65393012711	TDP-binding site; other site
65393012712	acceptor substrate-binding pocket; other site
65393012713	homodimer interface [polypeptide binding]; other site
65393012714	DAK2 domain; Region: Dak2; cl03685
65393012715	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468
65393012716	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
65393012717	aspartate aminotransferase; Provisional; Region: PRK05764
65393012718	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
65393012719	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393012720	homodimer interface [polypeptide binding]; other site
65393012721	catalytic residue [active]
65393012722	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393012723	Ligand Binding Site [chemical binding]; other site
65393012724	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
65393012725	Family description; Region: UvrD_C_2; pfam13538
65393012726	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393012727	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393012728	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393012729	DNA methylase; Region: N6_N4_Mtase; cl17433
65393012730	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
65393012731	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
65393012732	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
65393012733	Na binding site [ion binding]; other site
65393012734	TIR domain; Region: TIR_2; pfam13676
65393012735	TIR domain; Region: TIR_2; pfam13676
65393012736	TIR domain; Region: TIR_2; pfam13676
65393012737	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393012738	structural tetrad; other site
65393012739	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393012740	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393012741	structural tetrad; other site
65393012742	WD40 repeats; Region: WD40; smart00320
65393012743	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393012744	Coenzyme A binding pocket [chemical binding]; other site
65393012745	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
65393012746	hypothetical protein; Reviewed; Region: PRK09588
65393012747	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
65393012748	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
65393012749	active site
65393012750	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
65393012751	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
65393012752	ligand binding site [chemical binding]; other site
65393012753	flexible hinge region; other site
65393012754	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
65393012755	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
65393012756	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
65393012757	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
65393012758	protein binding site [polypeptide binding]; other site
65393012759	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
65393012760	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
65393012761	homodimer interface [polypeptide binding]; other site
65393012762	substrate-cofactor binding pocket; other site
65393012763	catalytic residue [active]
65393012764	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
65393012765	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
65393012766	dimer interface [polypeptide binding]; other site
65393012767	active site
65393012768	glycine-pyridoxal phosphate binding site [chemical binding]; other site
65393012769	folate binding site [chemical binding]; other site
65393012770	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
65393012771	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
65393012772	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
65393012773	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
65393012774	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
65393012775	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
65393012776	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
65393012777	protein binding site [polypeptide binding]; other site
65393012778	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
65393012779	Domain interface; other site
65393012780	Peptide binding site; other site
65393012781	Active site tetrad [active]
65393012782	GxxExxY protein; Region: GxxExxY; TIGR04256
65393012783	phosphate acetyltransferase; Reviewed; Region: PRK05632
65393012784	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65393012785	DRTGG domain; Region: DRTGG; pfam07085
65393012786	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
65393012787	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
65393012788	putative rRNA binding site [nucleotide binding]; other site
65393012789	PIN domain; Region: PIN_3; pfam13470
65393012790	Phycobilisome protein; Region: Phycobilisome; cl08227
65393012791	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
65393012792	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
65393012793	nucleophile elbow; other site
65393012794	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
65393012795	FtsH Extracellular; Region: FtsH_ext; pfam06480
65393012796	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
65393012797	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393012798	Walker A motif; other site
65393012799	ATP binding site [chemical binding]; other site
65393012800	Walker B motif; other site
65393012801	arginine finger; other site
65393012802	Peptidase family M41; Region: Peptidase_M41; pfam01434
65393012803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
65393012804	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
65393012805	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
65393012806	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
65393012807	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
65393012808	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
65393012809	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
65393012810	putative dimer interface [polypeptide binding]; other site
65393012811	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65393012812	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65393012813	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
65393012814	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
65393012815	active site residue [active]
65393012816	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
65393012817	Flavoprotein; Region: Flavoprotein; pfam02441
65393012818	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
65393012819	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
65393012820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
65393012821	conserved hypothetical protein; Region: TIGR03492
65393012822	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
65393012823	HD domain; Region: HD_4; pfam13328
65393012824	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
65393012825	synthetase active site [active]
65393012826	NTP binding site [chemical binding]; other site
65393012827	metal binding site [ion binding]; metal-binding site
65393012828	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
65393012829	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
65393012830	DGQHR domain; Region: DGQHR; TIGR03187
65393012831	DNA-sulfur modification-associated; Region: DndB; cl17621
65393012832	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
65393012833	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65393012834	active site
65393012835	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65393012836	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
65393012837	EamA-like transporter family; Region: EamA; pfam00892
65393012838	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
65393012839	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
65393012840	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
65393012841	substrate-cofactor binding pocket; other site
65393012842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393012843	catalytic residue [active]
65393012844	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
65393012845	DGQHR domain; Region: DGQHR; TIGR03187
65393012846	DNA-sulfur modification-associated; Region: DndB; cl17621
65393012847	DNA-sulfur modification-associated; Region: DndB; cl17621
65393012848	DGQHR domain; Region: DGQHR; TIGR03187
65393012849	Uncharacterized conserved protein [Function unknown]; Region: COG5464
65393012850	DNA-sulfur modification-associated; Region: DndB; pfam14072
65393012851	DGQHR domain; Region: DGQHR; TIGR03187
65393012852	hypothetical protein; Provisional; Region: PRK06850
65393012853	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
65393012854	Active Sites [active]
65393012855	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
65393012856	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
65393012857	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
65393012858	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393012859	AAA domain; Region: AAA_23; pfam13476
65393012860	Walker A/P-loop; other site
65393012861	ATP binding site [chemical binding]; other site
65393012862	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393012863	ABC transporter signature motif; other site
65393012864	Walker B; other site
65393012865	D-loop; other site
65393012866	H-loop/switch region; other site
65393012867	GUN4-like; Region: GUN4; pfam05419
65393012868	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
65393012869	PRC-barrel domain; Region: PRC; pfam05239
65393012870	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
65393012871	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
65393012872	integron integrase; Region: integrase_gron; TIGR02249
65393012873	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
65393012874	active site
65393012875	DNA binding site [nucleotide binding]
65393012876	Int/Topo IB signature motif; other site
65393012877	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
65393012878	dimerization interface [polypeptide binding]; other site
65393012879	putative DNA binding site [nucleotide binding]; other site
65393012880	putative Zn2+ binding site [ion binding]; other site
65393012881	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
65393012882	Domain of unknown function DUF20; Region: UPF0118; pfam01594
65393012883	GUN4-like; Region: GUN4; pfam05419
65393012884	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
65393012885	classical (c) SDRs; Region: SDR_c; cd05233
65393012886	NAD(P) binding site [chemical binding]; other site
65393012887	active site
65393012888	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
65393012889	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
65393012890	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
65393012891	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
65393012892	Clp amino terminal domain; Region: Clp_N; pfam02861
65393012893	Clp amino terminal domain; Region: Clp_N; pfam02861
65393012894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393012895	Walker A motif; other site
65393012896	ATP binding site [chemical binding]; other site
65393012897	Walker B motif; other site
65393012898	arginine finger; other site
65393012899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393012900	Walker A motif; other site
65393012901	ATP binding site [chemical binding]; other site
65393012902	Walker B motif; other site
65393012903	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
65393012904	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
65393012905	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393012906	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393012907	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
65393012908	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393012909	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
65393012910	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
65393012911	iron-sulfur cluster [ion binding]; other site
65393012912	[2Fe-2S] cluster binding site [ion binding]; other site
65393012913	Uncharacterized conserved protein [Function unknown]; Region: COG3349
65393012914	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
65393012915	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393012916	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65393012917	phosphopeptide binding site; other site
65393012918	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393012919	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393012920	metal binding site [ion binding]; metal-binding site
65393012921	active site
65393012922	I-site; other site
65393012923	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393012924	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
65393012925	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393012926	Walker A/P-loop; other site
65393012927	ATP binding site [chemical binding]; other site
65393012928	Q-loop/lid; other site
65393012929	ABC transporter signature motif; other site
65393012930	Walker B; other site
65393012931	D-loop; other site
65393012932	H-loop/switch region; other site
65393012933	ABC-2 type transporter; Region: ABC2_membrane; cl17235
65393012934	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
65393012935	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
65393012936	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
65393012937	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65393012938	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
65393012939	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
65393012940	dimer interface [polypeptide binding]; other site
65393012941	PYR/PP interface [polypeptide binding]; other site
65393012942	TPP binding site [chemical binding]; other site
65393012943	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
65393012944	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
65393012945	TPP-binding site [chemical binding]; other site
65393012946	dimer interface [polypeptide binding]; other site
65393012947	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393012948	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
65393012949	Coenzyme A binding pocket [chemical binding]; other site
65393012950	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
65393012951	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393012952	NAD(P) binding site [chemical binding]; other site
65393012953	active site
65393012954	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
65393012955	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
65393012956	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
65393012957	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
65393012958	TM-ABC transporter signature motif; other site
65393012959	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
65393012960	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
65393012961	Walker A/P-loop; other site
65393012962	ATP binding site [chemical binding]; other site
65393012963	Q-loop/lid; other site
65393012964	ABC transporter signature motif; other site
65393012965	Walker B; other site
65393012966	D-loop; other site
65393012967	H-loop/switch region; other site
65393012968	Uncharacterized conserved protein [Function unknown]; Region: COG0397
65393012969	hypothetical protein; Validated; Region: PRK00029
65393012970	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
65393012971	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
65393012972	acyl-activating enzyme (AAE) consensus motif; other site
65393012973	putative AMP binding site [chemical binding]; other site
65393012974	putative active site [active]
65393012975	putative CoA binding site [chemical binding]; other site
65393012976	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
65393012977	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
65393012978	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
65393012979	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
65393012980	ATP-binding site [chemical binding]; other site
65393012981	Gluconate-6-phosphate binding site [chemical binding]; other site
65393012982	Shikimate kinase; Region: SKI; pfam01202
65393012983	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
65393012984	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393012985	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
65393012986	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
65393012987	Integral membrane protein DUF92; Region: DUF92; pfam01940
65393012988	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393012989	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
65393012990	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
65393012991	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
65393012992	generic binding surface I; other site
65393012993	generic binding surface II; other site
65393012994	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
65393012995	MutS domain III; Region: MutS_III; pfam05192
65393012996	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
65393012997	Walker A/P-loop; other site
65393012998	ATP binding site [chemical binding]; other site
65393012999	Q-loop/lid; other site
65393013000	ABC transporter signature motif; other site
65393013001	Walker B; other site
65393013002	D-loop; other site
65393013003	H-loop/switch region; other site
65393013004	Smr domain; Region: Smr; pfam01713
65393013005	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393013006	binding surface
65393013007	TPR repeat; Region: TPR_11; pfam13414
65393013008	TPR motif; other site
65393013009	TPR repeat; Region: TPR_11; pfam13414
65393013010	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
65393013011	cheY-homologous receiver domain; Region: REC; smart00448
65393013012	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393013013	phosphorylation site [posttranslational modification]
65393013014	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393013015	DNA binding residues [nucleotide binding]
65393013016	dimerization interface [polypeptide binding]; other site
65393013017	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
65393013018	metal ion-dependent adhesion site (MIDAS); other site
65393013019	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
65393013020	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65393013021	active site
65393013022	NTP binding site [chemical binding]; other site
65393013023	metal binding triad [ion binding]; metal-binding site
65393013024	antibiotic binding site [chemical binding]; other site
65393013025	Protein of unknown function DUF86; Region: DUF86; cl01031
65393013026	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
65393013027	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
65393013028	Leucine-rich repeats; other site
65393013029	Leucine rich repeat; Region: LRR_8; pfam13855
65393013030	Substrate binding site [chemical binding]; other site
65393013031	Leucine rich repeat; Region: LRR_8; pfam13855
65393013032	Leucine rich repeat; Region: LRR_8; pfam13855
65393013033	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
65393013034	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
65393013035	G1 box; other site
65393013036	GTP/Mg2+ binding site [chemical binding]; other site
65393013037	G2 box; other site
65393013038	Switch I region; other site
65393013039	G3 box; other site
65393013040	Switch II region; other site
65393013041	G4 box; other site
65393013042	G5 box; other site
65393013043	TIR domain; Region: TIR_2; pfam13676
65393013044	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
65393013045	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
65393013046	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
65393013047	Active_site [active]
65393013048	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393013049	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
65393013050	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
65393013051	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
65393013052	NAD binding site [chemical binding]; other site
65393013053	substrate binding site [chemical binding]; other site
65393013054	active site
65393013055	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393013056	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
65393013057	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393013058	putative active site [active]
65393013059	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393013060	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393013061	Probable transposase; Region: OrfB_IS605; pfam01385
65393013062	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393013063	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
65393013064	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
65393013065	active pocket/dimerization site; other site
65393013066	active site
65393013067	phosphorylation site [posttranslational modification]
65393013068	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
65393013069	dimerization domain swap beta strand [polypeptide binding]; other site
65393013070	regulatory protein interface [polypeptide binding]; other site
65393013071	active site
65393013072	regulatory phosphorylation site [posttranslational modification]; other site
65393013073	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
65393013074	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
65393013075	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
65393013076	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
65393013077	EamA-like transporter family; Region: EamA; cl17759
65393013078	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
65393013079	catalytic motif [active]
65393013080	Catalytic residue [active]
65393013081	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
65393013082	catalytic motif [active]
65393013083	Catalytic residue [active]
65393013084	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
65393013085	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
65393013086	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
65393013087	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393013088	FOG: CBS domain [General function prediction only]; Region: COG0517
65393013089	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
65393013090	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
65393013091	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393013092	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65393013093	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393013094	DNA binding residues [nucleotide binding]
65393013095	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716
65393013096	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
65393013097	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
65393013098	active site
65393013099	substrate binding site [chemical binding]; other site
65393013100	metal binding site [ion binding]; metal-binding site
65393013101	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
65393013102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
65393013103	S-adenosylmethionine binding site [chemical binding]; other site
65393013104	BON domain; Region: BON; cl02771
65393013105	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393013106	TPR motif; other site
65393013107	Tetratricopeptide repeat; Region: TPR_16; pfam13432
65393013108	binding surface
65393013109	TPR repeat; Region: TPR_11; pfam13414
65393013110	PAS fold; Region: PAS_4; pfam08448
65393013111	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013112	putative active site [active]
65393013113	heme pocket [chemical binding]; other site
65393013114	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013115	PAS domain; Region: PAS_9; pfam13426
65393013116	putative active site [active]
65393013117	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013118	PAS domain; Region: PAS_9; pfam13426
65393013119	putative active site [active]
65393013120	heme pocket [chemical binding]; other site
65393013121	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393013122	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393013123	metal binding site [ion binding]; metal-binding site
65393013124	active site
65393013125	I-site; other site
65393013126	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393013127	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
65393013128	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65393013129	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
65393013130	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
65393013131	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
65393013132	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
65393013133	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
65393013134	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
65393013135	RNA binding site [nucleotide binding]; other site
65393013136	TIGR03943 family protein; Region: TIGR03943
65393013137	Predicted permeases [General function prediction only]; Region: COG0701
65393013138	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
65393013139	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
65393013140	transmembrane helices; other site
65393013141	TrkA-C domain; Region: TrkA_C; pfam02080
65393013142	TrkA-C domain; Region: TrkA_C; pfam02080
65393013143	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
65393013144	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
65393013145	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
65393013146	transmembrane helices; other site
65393013147	Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617
65393013148	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
65393013149	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
65393013150	catalytic residues [active]
65393013151	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
65393013152	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
65393013153	dimer interface [polypeptide binding]; other site
65393013154	active site
65393013155	metal binding site [ion binding]; metal-binding site
65393013156	glutathione binding site [chemical binding]; other site
65393013157	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
65393013158	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
65393013159	active site clefts [active]
65393013160	zinc binding site [ion binding]; other site
65393013161	dimer interface [polypeptide binding]; other site
65393013162	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
65393013163	Domain of unknown function DUF21; Region: DUF21; pfam01595
65393013164	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
65393013165	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
65393013166	proposed catalytic triad [active]
65393013167	active site nucleophile [active]
65393013168	4-alpha-glucanotransferase; Provisional; Region: PRK14508
65393013169	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
65393013170	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
65393013171	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393013172	GAF domain; Region: GAF; pfam01590
65393013173	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393013174	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393013175	dimer interface [polypeptide binding]; other site
65393013176	phosphorylation site [posttranslational modification]
65393013177	GUN4-like; Region: GUN4; pfam05419
65393013178	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
65393013179	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
65393013180	active site
65393013181	nucleotide binding site [chemical binding]; other site
65393013182	HIGH motif; other site
65393013183	KMSKS motif; other site
65393013184	spermine synthase; Region: PLN02823
65393013185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393013186	S-adenosylmethionine binding site [chemical binding]; other site
65393013187	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
65393013188	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
65393013189	cofactor binding site; other site
65393013190	DNA binding site [nucleotide binding]
65393013191	substrate interaction site [chemical binding]; other site
65393013192	SnoaL-like domain; Region: SnoaL_2; pfam12680
65393013193	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
65393013194	Part of AAA domain; Region: AAA_19; pfam13245
65393013195	Family description; Region: UvrD_C_2; pfam13538
65393013196	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
65393013197	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
65393013198	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
65393013199	putative ligand binding site [chemical binding]; other site
65393013200	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393013201	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393013202	active site
65393013203	ATP binding site [chemical binding]; other site
65393013204	substrate binding site [chemical binding]; other site
65393013205	activation loop (A-loop); other site
65393013206	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
65393013207	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
65393013208	putative NAD(P) binding site [chemical binding]; other site
65393013209	active site
65393013210	biotin synthase; Region: bioB; TIGR00433
65393013211	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
65393013212	FeS/SAM binding site; other site
65393013213	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
65393013214	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
65393013215	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
65393013216	lipoprotein signal peptidase; Provisional; Region: PRK14787
65393013217	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
65393013218	DNA methylase; Region: N6_N4_Mtase; pfam01555
65393013219	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
65393013220	Peptidase family M50; Region: Peptidase_M50; pfam02163
65393013221	active site
65393013222	putative substrate binding region [chemical binding]; other site
65393013223	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
65393013224	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
65393013225	putative active site [active]
65393013226	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
65393013227	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
65393013228	photosystem I subunit VII; Region: psaC; CHL00065
65393013229	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65393013230	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
65393013231	active site
65393013232	NAD binding site [chemical binding]; other site
65393013233	metal binding site [ion binding]; metal-binding site
65393013234	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
65393013235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393013236	S-adenosylmethionine binding site [chemical binding]; other site
65393013237	hypothetical protein; Provisional; Region: PRK06849
65393013238	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65393013239	ATP-grasp domain; Region: ATP-grasp_4; cl17255
65393013240	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
65393013241	Na binding site [ion binding]; other site
65393013242	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
65393013243	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
65393013244	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
65393013245	acyl-activating enzyme (AAE) consensus motif; other site
65393013246	AMP binding site [chemical binding]; other site
65393013247	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393013248	proline/glycine betaine transporter; Provisional; Region: PRK10642
65393013249	TIR domain; Region: TIR_2; pfam13676
65393013250	GUN4-like; Region: GUN4; pfam05419
65393013251	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
65393013252	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
65393013253	PYR/PP interface [polypeptide binding]; other site
65393013254	dimer interface [polypeptide binding]; other site
65393013255	TPP binding site [chemical binding]; other site
65393013256	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
65393013257	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
65393013258	TPP-binding site [chemical binding]; other site
65393013259	dimer interface [polypeptide binding]; other site
65393013260	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
65393013261	CpeS-like protein; Region: CpeS; pfam09367
65393013262	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393013263	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013264	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
65393013265	putative active site [active]
65393013266	heme pocket [chemical binding]; other site
65393013267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013268	putative active site [active]
65393013269	heme pocket [chemical binding]; other site
65393013270	PAS domain S-box; Region: sensory_box; TIGR00229
65393013271	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013272	putative active site [active]
65393013273	heme pocket [chemical binding]; other site
65393013274	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393013275	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393013276	dimer interface [polypeptide binding]; other site
65393013277	phosphorylation site [posttranslational modification]
65393013278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393013279	ATP binding site [chemical binding]; other site
65393013280	Mg2+ binding site [ion binding]; other site
65393013281	G-X-G motif; other site
65393013282	Response regulator receiver domain; Region: Response_reg; pfam00072
65393013283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013284	active site
65393013285	phosphorylation site [posttranslational modification]
65393013286	intermolecular recognition site; other site
65393013287	dimerization interface [polypeptide binding]; other site
65393013288	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
65393013289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
65393013290	dimer interface [polypeptide binding]; other site
65393013291	conserved gate region; other site
65393013292	putative PBP binding loops; other site
65393013293	ABC-ATPase subunit interface; other site
65393013294	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393013295	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
65393013296	Walker A/P-loop; other site
65393013297	ATP binding site [chemical binding]; other site
65393013298	Q-loop/lid; other site
65393013299	ABC transporter signature motif; other site
65393013300	Walker B; other site
65393013301	D-loop; other site
65393013302	H-loop/switch region; other site
65393013303	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
65393013304	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
65393013305	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
65393013306	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
65393013307	methionine sulfoxide reductase A; Provisional; Region: PRK00058
65393013308	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
65393013309	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
65393013310	ResB-like family; Region: ResB; pfam05140
65393013311	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
65393013312	type II secretion system protein J; Region: gspJ; TIGR01711
65393013313	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
65393013314	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
65393013315	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
65393013316	CHASE2 domain; Region: CHASE2; pfam05226
65393013317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393013318	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393013319	ATP binding site [chemical binding]; other site
65393013320	Mg2+ binding site [ion binding]; other site
65393013321	G-X-G motif; other site
65393013322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013323	active site
65393013324	phosphorylation site [posttranslational modification]
65393013325	intermolecular recognition site; other site
65393013326	dimerization interface [polypeptide binding]; other site
65393013327	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
65393013328	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
65393013329	dimer interface [polypeptide binding]; other site
65393013330	motif 1; other site
65393013331	active site
65393013332	motif 2; other site
65393013333	motif 3; other site
65393013334	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
65393013335	anticodon binding site; other site
65393013336	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393013337	dimer interface [polypeptide binding]; other site
65393013338	phosphorylation site [posttranslational modification]
65393013339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393013340	ATP binding site [chemical binding]; other site
65393013341	G-X-G motif; other site
65393013342	Response regulator receiver domain; Region: Response_reg; pfam00072
65393013343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013344	active site
65393013345	phosphorylation site [posttranslational modification]
65393013346	intermolecular recognition site; other site
65393013347	dimerization interface [polypeptide binding]; other site
65393013348	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393013349	dimer interface [polypeptide binding]; other site
65393013350	phosphorylation site [posttranslational modification]
65393013351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393013352	ATP binding site [chemical binding]; other site
65393013353	Mg2+ binding site [ion binding]; other site
65393013354	G-X-G motif; other site
65393013355	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393013356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013357	active site
65393013358	phosphorylation site [posttranslational modification]
65393013359	intermolecular recognition site; other site
65393013360	dimerization interface [polypeptide binding]; other site
65393013361	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393013362	DNA binding site [nucleotide binding]
65393013363	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
65393013364	HlyD family secretion protein; Region: HlyD_3; pfam13437
65393013365	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
65393013366	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
65393013367	dimer interface [polypeptide binding]; other site
65393013368	substrate binding site [chemical binding]; other site
65393013369	ATP binding site [chemical binding]; other site
65393013370	cell division protein FtsZ; Validated; Region: PRK09330
65393013371	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
65393013372	nucleotide binding site [chemical binding]; other site
65393013373	SulA interaction site; other site
65393013374	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
65393013375	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
65393013376	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
65393013377	C-terminal peptidase (prc); Region: prc; TIGR00225
65393013378	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
65393013379	protein binding site [polypeptide binding]; other site
65393013380	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
65393013381	Catalytic dyad [active]
65393013382	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
65393013383	tetramer interface [polypeptide binding]; other site
65393013384	dimer interface [polypeptide binding]; other site
65393013385	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
65393013386	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
65393013387	Walker A motif; other site
65393013388	ATP binding site [chemical binding]; other site
65393013389	Walker B motif; other site
65393013390	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
65393013391	homodimer interface [polypeptide binding]; other site
65393013392	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
65393013393	active site pocket [active]
65393013394	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
65393013395	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
65393013396	OstA-like protein; Region: OstA; cl00844
65393013397	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
65393013398	calcium/proton exchanger (cax); Region: cax; TIGR00378
65393013399	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
65393013400	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
65393013401	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
65393013402	Peptidase family M50; Region: Peptidase_M50; pfam02163
65393013403	active site
65393013404	putative substrate binding region [chemical binding]; other site
65393013405	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
65393013406	Double zinc ribbon; Region: DZR; pfam12773
65393013407	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
65393013408	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
65393013409	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
65393013410	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
65393013411	phosphopeptide binding site; other site
65393013412	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
65393013413	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
65393013414	putative active site [active]
65393013415	Uncharacterized conserved protein [Function unknown]; Region: COG2928
65393013416	transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634
65393013417	putative RNA binding site [nucleotide binding]; other site
65393013418	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
65393013419	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
65393013420	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
65393013421	P loop; other site
65393013422	GTP binding site [chemical binding]; other site
65393013423	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
65393013424	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
65393013425	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
65393013426	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
65393013427	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
65393013428	active site
65393013429	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
65393013430	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
65393013431	catalytic triad [active]
65393013432	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
65393013433	Protein of unknown function (DUF497); Region: DUF497; pfam04365
65393013434	Protein of unknown function (DUF497); Region: DUF497; pfam04365
65393013435	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
65393013436	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
65393013437	HIGH motif; other site
65393013438	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
65393013439	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
65393013440	active site
65393013441	KMSKS motif; other site
65393013442	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
65393013443	tRNA binding surface [nucleotide binding]; other site
65393013444	anticodon binding site; other site
65393013445	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
65393013446	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
65393013447	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393013448	putative active site [active]
65393013449	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
65393013450	AAA domain; Region: AAA_21; pfam13304
65393013451	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393013452	Walker A/P-loop; other site
65393013453	Walker A/P-loop; other site
65393013454	ATP binding site [chemical binding]; other site
65393013455	ATP binding site [chemical binding]; other site
65393013456	precorrin-8X methylmutase; Provisional; Region: PRK05954
65393013457	Precorrin-8X methylmutase; Region: CbiC; pfam02570
65393013458	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
65393013459	putative homodimer interface [polypeptide binding]; other site
65393013460	active site
65393013461	SAM binding site [chemical binding]; other site
65393013462	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
65393013463	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393013464	S-adenosylmethionine binding site [chemical binding]; other site
65393013465	adaptive-response sensory kinase; Validated; Region: PRK09303
65393013466	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
65393013467	tetramer interface [polypeptide binding]; other site
65393013468	dimer interface [polypeptide binding]; other site
65393013469	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393013470	dimer interface [polypeptide binding]; other site
65393013471	phosphorylation site [posttranslational modification]
65393013472	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393013473	ATP binding site [chemical binding]; other site
65393013474	Mg2+ binding site [ion binding]; other site
65393013475	G-X-G motif; other site
65393013476	Uncharacterized conserved protein [Function unknown]; Region: COG1543
65393013477	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
65393013478	active site
65393013479	substrate binding site [chemical binding]; other site
65393013480	catalytic site [active]
65393013481	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
65393013482	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
65393013483	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
65393013484	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65393013485	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
65393013486	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393013487	motif II; other site
65393013488	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
65393013489	N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867
65393013490	Haemolysin XhlA; Region: XhlA; pfam10779
65393013491	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
65393013492	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393013493	MASE1; Region: MASE1; pfam05231
65393013494	GAF domain; Region: GAF_2; pfam13185
65393013495	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393013496	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393013497	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
65393013498	dimer interface [polypeptide binding]; other site
65393013499	phosphorylation site [posttranslational modification]
65393013500	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393013501	ATP binding site [chemical binding]; other site
65393013502	Mg2+ binding site [ion binding]; other site
65393013503	G-X-G motif; other site
65393013504	Response regulator receiver domain; Region: Response_reg; pfam00072
65393013505	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013506	active site
65393013507	phosphorylation site [posttranslational modification]
65393013508	intermolecular recognition site; other site
65393013509	dimerization interface [polypeptide binding]; other site
65393013510	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393013511	DNA binding residues [nucleotide binding]
65393013512	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
65393013513	nucleoside/Zn binding site; other site
65393013514	dimer interface [polypeptide binding]; other site
65393013515	catalytic motif [active]
65393013516	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
65393013517	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
65393013518	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393013519	short chain dehydrogenase; Provisional; Region: PRK07109
65393013520	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
65393013521	putative NAD(P) binding site [chemical binding]; other site
65393013522	active site
65393013523	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013524	PAS fold; Region: PAS_3; pfam08447
65393013525	putative active site [active]
65393013526	heme pocket [chemical binding]; other site
65393013527	PAS fold; Region: PAS_4; pfam08448
65393013528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393013529	dimer interface [polypeptide binding]; other site
65393013530	phosphorylation site [posttranslational modification]
65393013531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393013532	ATP binding site [chemical binding]; other site
65393013533	Mg2+ binding site [ion binding]; other site
65393013534	G-X-G motif; other site
65393013535	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
65393013536	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
65393013537	membrane protein; Provisional; Region: PRK14419
65393013538	acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531
65393013539	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
65393013540	carboxyltransferase (CT) interaction site; other site
65393013541	biotinylation site [posttranslational modification]; other site
65393013542	elongation factor P; Validated; Region: PRK00529
65393013543	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
65393013544	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
65393013545	RNA binding site [nucleotide binding]; other site
65393013546	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
65393013547	RNA binding site [nucleotide binding]; other site
65393013548	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
65393013549	active site
65393013550	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013551	active site
65393013552	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
65393013553	phosphorylation site [posttranslational modification]
65393013554	intermolecular recognition site; other site
65393013555	dimerization interface [polypeptide binding]; other site
65393013556	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393013557	metal binding site [ion binding]; metal-binding site
65393013558	active site
65393013559	I-site; other site
65393013560	Cache domain; Region: Cache_1; pfam02743
65393013561	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
65393013562	dimerization interface [polypeptide binding]; other site
65393013563	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
65393013564	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013565	putative active site [active]
65393013566	heme pocket [chemical binding]; other site
65393013567	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393013568	dimer interface [polypeptide binding]; other site
65393013569	phosphorylation site [posttranslational modification]
65393013570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393013571	ATP binding site [chemical binding]; other site
65393013572	Mg2+ binding site [ion binding]; other site
65393013573	G-X-G motif; other site
65393013574	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393013575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013576	active site
65393013577	phosphorylation site [posttranslational modification]
65393013578	intermolecular recognition site; other site
65393013579	dimerization interface [polypeptide binding]; other site
65393013580	hypothetical protein; Provisional; Region: PRK02724
65393013581	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
65393013582	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
65393013583	gamma subunit interface [polypeptide binding]; other site
65393013584	epsilon subunit interface [polypeptide binding]; other site
65393013585	LBP interface [polypeptide binding]; other site
65393013586	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
65393013587	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
65393013588	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
65393013589	alpha subunit interaction interface [polypeptide binding]; other site
65393013590	Walker A motif; other site
65393013591	ATP binding site [chemical binding]; other site
65393013592	Walker B motif; other site
65393013593	inhibitor binding site; inhibition site
65393013594	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
65393013595	Protein required for attachment to host cells; Region: Host_attach; pfam10116
65393013596	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
65393013597	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
65393013598	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
65393013599	homodimer interface [polypeptide binding]; other site
65393013600	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393013601	catalytic residue [active]
65393013602	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393013603	Ligand Binding Site [chemical binding]; other site
65393013604	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393013605	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
65393013606	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393013607	putative active site [active]
65393013608	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
65393013609	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
65393013610	DNA binding site [nucleotide binding]
65393013611	catalytic residue [active]
65393013612	H2TH interface [polypeptide binding]; other site
65393013613	putative catalytic residues [active]
65393013614	turnover-facilitating residue; other site
65393013615	intercalation triad [nucleotide binding]; other site
65393013616	8OG recognition residue [nucleotide binding]; other site
65393013617	putative reading head residues; other site
65393013618	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
65393013619	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
65393013620	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
65393013621	Connector enhancer of kinase suppressor of ras; Region: CRIC_ras_sig; pfam10534
65393013622	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393013623	putative active site [active]
65393013624	DNA primase; Validated; Region: dnaG; PRK05667
65393013625	CHC2 zinc finger; Region: zf-CHC2; pfam01807
65393013626	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
65393013627	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
65393013628	active site
65393013629	metal binding site [ion binding]; metal-binding site
65393013630	interdomain interaction site; other site
65393013631	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
65393013632	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
65393013633	catalytic residues [active]
65393013634	GUN4-like; Region: GUN4; pfam05419
65393013635	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393013636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013637	active site
65393013638	phosphorylation site [posttranslational modification]
65393013639	intermolecular recognition site; other site
65393013640	dimerization interface [polypeptide binding]; other site
65393013641	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393013642	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393013643	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393013644	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393013645	metal binding site [ion binding]; metal-binding site
65393013646	active site
65393013647	I-site; other site
65393013648	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013649	PAS fold; Region: PAS_3; pfam08447
65393013650	putative active site [active]
65393013651	heme pocket [chemical binding]; other site
65393013652	PAS domain S-box; Region: sensory_box; TIGR00229
65393013653	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013654	putative active site [active]
65393013655	heme pocket [chemical binding]; other site
65393013656	PAS fold; Region: PAS_4; pfam08448
65393013657	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013658	putative active site [active]
65393013659	heme pocket [chemical binding]; other site
65393013660	PAS fold; Region: PAS_4; pfam08448
65393013661	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013662	putative active site [active]
65393013663	heme pocket [chemical binding]; other site
65393013664	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393013665	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393013666	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393013667	dimer interface [polypeptide binding]; other site
65393013668	phosphorylation site [posttranslational modification]
65393013669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393013670	ATP binding site [chemical binding]; other site
65393013671	Mg2+ binding site [ion binding]; other site
65393013672	G-X-G motif; other site
65393013673	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
65393013674	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
65393013675	RNA binding site [nucleotide binding]; other site
65393013676	active site
65393013677	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
65393013678	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
65393013679	RNA/DNA hybrid binding site [nucleotide binding]; other site
65393013680	active site
65393013681	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
65393013682	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
65393013683	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
65393013684	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
65393013685	Uncharacterized conserved protein [Function unknown]; Region: COG3937
65393013686	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
65393013687	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
65393013688	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
65393013689	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
65393013690	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
65393013691	TPR repeat; Region: TPR_11; pfam13414
65393013692	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393013693	binding surface
65393013694	TPR motif; other site
65393013695	TPR repeat; Region: TPR_11; pfam13414
65393013696	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393013697	binding surface
65393013698	TPR repeat; Region: TPR_11; pfam13414
65393013699	TPR motif; other site
65393013700	TPR repeat; Region: TPR_11; pfam13414
65393013701	Tetratricopeptide repeat; Region: TPR_1; pfam00515
65393013702	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393013703	binding surface
65393013704	TPR motif; other site
65393013705	TPR repeat; Region: TPR_11; pfam13414
65393013706	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
65393013707	DctM-like transporters; Region: DctM; pfam06808
65393013708	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
65393013709	PAS domain; Region: PAS_9; pfam13426
65393013710	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393013711	dimer interface [polypeptide binding]; other site
65393013712	phosphorylation site [posttranslational modification]
65393013713	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393013714	ATP binding site [chemical binding]; other site
65393013715	Mg2+ binding site [ion binding]; other site
65393013716	G-X-G motif; other site
65393013717	Response regulator receiver domain; Region: Response_reg; pfam00072
65393013718	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013719	active site
65393013720	phosphorylation site [posttranslational modification]
65393013721	intermolecular recognition site; other site
65393013722	dimerization interface [polypeptide binding]; other site
65393013723	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393013724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013725	active site
65393013726	phosphorylation site [posttranslational modification]
65393013727	intermolecular recognition site; other site
65393013728	dimerization interface [polypeptide binding]; other site
65393013729	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393013730	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393013731	PAS domain S-box; Region: sensory_box; TIGR00229
65393013732	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
65393013733	putative active site [active]
65393013734	heme pocket [chemical binding]; other site
65393013735	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393013736	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393013737	metal binding site [ion binding]; metal-binding site
65393013738	active site
65393013739	I-site; other site
65393013740	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393013741	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393013742	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
65393013743	active site
65393013744	metal binding site [ion binding]; metal-binding site
65393013745	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
65393013746	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
65393013747	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
65393013748	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
65393013749	catalytic site [active]
65393013750	putative active site [active]
65393013751	putative substrate binding site [chemical binding]; other site
65393013752	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
65393013753	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
65393013754	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
65393013755	AAA domain; Region: AAA_22; pfam13401
65393013756	phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172
65393013757	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
65393013758	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
65393013759	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
65393013760	Sm and related proteins; Region: Sm_like; cl00259
65393013761	heptamer interface [polypeptide binding]; other site
65393013762	Sm1 motif; other site
65393013763	hexamer interface [polypeptide binding]; other site
65393013764	RNA binding site [nucleotide binding]; other site
65393013765	Sm2 motif; other site
65393013766	Late competence development protein ComFB; Region: ComFB; pfam10719
65393013767	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
65393013768	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393013769	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393013770	DNA binding residues [nucleotide binding]
65393013771	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
65393013772	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
65393013773	putative active site pocket [active]
65393013774	dimerization interface [polypeptide binding]; other site
65393013775	putative catalytic residue [active]
65393013776	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
65393013777	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
65393013778	D-xylulose kinase; Region: XylB; TIGR01312
65393013779	nucleotide binding site [chemical binding]; other site
65393013780	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
65393013781	nudix motif; other site
65393013782	Ion channel; Region: Ion_trans_2; pfam07885
65393013783	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
65393013784	TrkA-N domain; Region: TrkA_N; pfam02254
65393013785	TrkA-C domain; Region: TrkA_C; pfam02080
65393013786	acetylornithine aminotransferase; Provisional; Region: PRK02627
65393013787	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
65393013788	inhibitor-cofactor binding pocket; inhibition site
65393013789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393013790	catalytic residue [active]
65393013791	Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549
65393013792	DNA methylase; Region: N6_N4_Mtase; cl17433
65393013793	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393013794	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
65393013795	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
65393013796	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
65393013797	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
65393013798	Cytochrome P450; Region: p450; cl12078
65393013799	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393013800	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393013801	Probable transposase; Region: OrfB_IS605; pfam01385
65393013802	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393013803	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
65393013804	Ycf39; Provisional; Region: ycf39; CHL00194
65393013805	NAD(P) binding site [chemical binding]; other site
65393013806	putative active site [active]
65393013807	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
65393013808	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
65393013809	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
65393013810	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
65393013811	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
65393013812	Tubulin like; Region: Tubulin_2; pfam13809
65393013813	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
65393013814	Double zinc ribbon; Region: DZR; pfam12773
65393013815	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
65393013816	apolar tunnel; other site
65393013817	heme binding site [chemical binding]; other site
65393013818	dimerization interface [polypeptide binding]; other site
65393013819	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
65393013820	Transposase; Region: DDE_Tnp_ISL3; pfam01610
65393013821	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
65393013822	metal ion-dependent adhesion site (MIDAS); other site
65393013823	TPR repeat; Region: TPR_11; pfam13414
65393013824	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
65393013825	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
65393013826	putative ligand binding site [chemical binding]; other site
65393013827	Iron permease FTR1 family; Region: FTR1; cl00475
65393013828	Ferritin-like domain; Region: Ferritin; pfam00210
65393013829	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
65393013830	dinuclear metal binding motif [ion binding]; other site
65393013831	Thf1-like protein; Reviewed; Region: PRK13266
65393013832	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
65393013833	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
65393013834	hypothetical protein; Provisional; Region: PRK02509
65393013835	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
65393013836	Uncharacterized conserved protein [Function unknown]; Region: COG1615
65393013837	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393013838	putative active site [active]
65393013839	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
65393013840	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
65393013841	tRNA; other site
65393013842	putative tRNA binding site [nucleotide binding]; other site
65393013843	putative NADP binding site [chemical binding]; other site
65393013844	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
65393013845	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
65393013846	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
65393013847	putative active site [active]
65393013848	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
65393013849	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
65393013850	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
65393013851	dimerization interface [polypeptide binding]; other site
65393013852	domain crossover interface; other site
65393013853	redox-dependent activation switch; other site
65393013854	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
65393013855	Mechanosensitive ion channel; Region: MS_channel; pfam00924
65393013856	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
65393013857	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013858	active site
65393013859	phosphorylation site [posttranslational modification]
65393013860	intermolecular recognition site; other site
65393013861	dimerization interface [polypeptide binding]; other site
65393013862	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
65393013863	DNA binding site [nucleotide binding]
65393013864	CHASE3 domain; Region: CHASE3; pfam05227
65393013865	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393013866	dimer interface [polypeptide binding]; other site
65393013867	phosphorylation site [posttranslational modification]
65393013868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393013869	ATP binding site [chemical binding]; other site
65393013870	Mg2+ binding site [ion binding]; other site
65393013871	G-X-G motif; other site
65393013872	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
65393013873	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
65393013874	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
65393013875	active site
65393013876	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
65393013877	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
65393013878	active site
65393013879	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
65393013880	protein binding site [polypeptide binding]; other site
65393013881	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
65393013882	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
65393013883	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
65393013884	minor groove reading motif; other site
65393013885	helix-hairpin-helix signature motif; other site
65393013886	substrate binding pocket [chemical binding]; other site
65393013887	active site
65393013888	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
65393013889	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393013890	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65393013891	Protein of unknown function (DUF3754); Region: DUF3754; pfam12576
65393013892	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
65393013893	phosphoribulokinase; Provisional; Region: PRK07429
65393013894	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
65393013895	active site
65393013896	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
65393013897	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
65393013898	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
65393013899	dimerization interface [polypeptide binding]; other site
65393013900	FAD binding pocket [chemical binding]; other site
65393013901	FAD binding motif [chemical binding]; other site
65393013902	catalytic residues [active]
65393013903	NAD binding pocket [chemical binding]; other site
65393013904	phosphate binding motif [ion binding]; other site
65393013905	beta-alpha-beta structure motif; other site
65393013906	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
65393013907	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
65393013908	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
65393013909	TIGR03032 family protein; Region: TIGR03032
65393013910	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
65393013911	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
65393013912	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
65393013913	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
65393013914	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
65393013915	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
65393013916	metal ion-dependent adhesion site (MIDAS); other site
65393013917	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393013918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013919	active site
65393013920	phosphorylation site [posttranslational modification]
65393013921	intermolecular recognition site; other site
65393013922	dimerization interface [polypeptide binding]; other site
65393013923	Domain of unknown function DUF20; Region: UPF0118; pfam01594
65393013924	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
65393013925	Domain of unknown function DUF39; Region: DUF39; pfam01837
65393013926	putative methanogenesis marker 16 metalloprotein; Region: methan_mark_16; TIGR03287
65393013927	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
65393013928	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
65393013929	G1 box; other site
65393013930	GTP/Mg2+ binding site [chemical binding]; other site
65393013931	Switch I region; other site
65393013932	G2 box; other site
65393013933	Switch II region; other site
65393013934	G3 box; other site
65393013935	G4 box; other site
65393013936	G5 box; other site
65393013937	Domain of unknown function (DUF697); Region: DUF697; pfam05128
65393013938	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
65393013939	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
65393013940	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
65393013941	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
65393013942	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393013943	motif II; other site
65393013944	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
65393013945	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
65393013946	putative NAD(P) binding site [chemical binding]; other site
65393013947	putative substrate binding site [chemical binding]; other site
65393013948	catalytic Zn binding site [ion binding]; other site
65393013949	structural Zn binding site [ion binding]; other site
65393013950	dimer interface [polypeptide binding]; other site
65393013951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013952	active site
65393013953	phosphorylation site [posttranslational modification]
65393013954	intermolecular recognition site; other site
65393013955	dimerization interface [polypeptide binding]; other site
65393013956	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
65393013957	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
65393013958	metal binding site [ion binding]; metal-binding site
65393013959	active site
65393013960	I-site; other site
65393013961	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
65393013962	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
65393013963	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
65393013964	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
65393013965	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
65393013966	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
65393013967	dimerization interface [polypeptide binding]; other site
65393013968	DPS ferroxidase diiron center [ion binding]; other site
65393013969	ion pore; other site
65393013970	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
65393013971	dimer interface [polypeptide binding]; other site
65393013972	[2Fe-2S] cluster binding site [ion binding]; other site
65393013973	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
65393013974	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
65393013975	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
65393013976	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
65393013977	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
65393013978	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
65393013979	ATP-grasp domain; Region: ATP-grasp_4; cl17255
65393013980	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
65393013981	IMP binding site; other site
65393013982	dimer interface [polypeptide binding]; other site
65393013983	interdomain contacts; other site
65393013984	partial ornithine binding site; other site
65393013985	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
65393013986	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
65393013987	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
65393013988	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393013989	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393013990	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393013991	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
65393013992	dimer interface [polypeptide binding]; other site
65393013993	phosphorylation site [posttranslational modification]
65393013994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393013995	ATP binding site [chemical binding]; other site
65393013996	Mg2+ binding site [ion binding]; other site
65393013997	G-X-G motif; other site
65393013998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393013999	active site
65393014000	phosphorylation site [posttranslational modification]
65393014001	intermolecular recognition site; other site
65393014002	dimerization interface [polypeptide binding]; other site
65393014003	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
65393014004	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
65393014005	putative active site cavity [active]
65393014006	H+ Antiporter protein; Region: 2A0121; TIGR00900
65393014007	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
65393014008	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
65393014009	active site
65393014010	catalytic site [active]
65393014011	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
65393014012	Ligand Binding Site [chemical binding]; other site
65393014013	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
65393014014	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
65393014015	active site
65393014016	trimer interface [polypeptide binding]; other site
65393014017	allosteric site; other site
65393014018	active site lid [active]
65393014019	hexamer (dimer of trimers) interface [polypeptide binding]; other site
65393014020	agmatinase; Region: agmatinase; TIGR01230
65393014021	Agmatinase-like family; Region: Agmatinase-like; cd09990
65393014022	active site
65393014023	oligomer interface [polypeptide binding]; other site
65393014024	Mn binding site [ion binding]; other site
65393014025	hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100
65393014026	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
65393014027	hydrogenase accessory protein HypB; Region: hypB; TIGR00073
65393014028	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393014029	putative active site [active]
65393014030	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
65393014031	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393014032	Coenzyme A binding pocket [chemical binding]; other site
65393014033	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
65393014034	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
65393014035	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
65393014036	Coenzyme A binding pocket [chemical binding]; other site
65393014037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
65393014038	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
65393014039	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
65393014040	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
65393014041	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
65393014042	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
65393014043	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
65393014044	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
65393014045	Coenzyme A binding pocket [chemical binding]; other site
65393014046	tellurium resistance terB-like protein; Region: terB_like; cd07177
65393014047	metal binding site [ion binding]; metal-binding site
65393014048	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
65393014049	GTPase CgtA; Reviewed; Region: obgE; PRK12299
65393014050	GTP1/OBG; Region: GTP1_OBG; pfam01018
65393014051	Obg GTPase; Region: Obg; cd01898
65393014052	G1 box; other site
65393014053	GTP/Mg2+ binding site [chemical binding]; other site
65393014054	Switch I region; other site
65393014055	G2 box; other site
65393014056	G3 box; other site
65393014057	Switch II region; other site
65393014058	G4 box; other site
65393014059	G5 box; other site
65393014060	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
65393014061	KH domain; Region: KH_4; pfam13083
65393014062	ribosomal protein S16; Region: rps16; CHL00005
65393014063	BolA-like protein; Region: BolA; pfam01722
65393014064	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014065	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393014066	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014067	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014068	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014069	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
65393014070	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
65393014071	substrate binding site [chemical binding]; other site
65393014072	hexamer interface [polypeptide binding]; other site
65393014073	metal binding site [ion binding]; metal-binding site
65393014074	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
65393014075	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
65393014076	catalytic residues [active]
65393014077	recombination protein F; Reviewed; Region: recF; PRK00064
65393014078	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
65393014079	Walker A/P-loop; other site
65393014080	ATP binding site [chemical binding]; other site
65393014081	Q-loop/lid; other site
65393014082	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393014083	ABC transporter signature motif; other site
65393014084	Walker B; other site
65393014085	D-loop; other site
65393014086	H-loop/switch region; other site
65393014087	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
65393014088	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
65393014089	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
65393014090	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
65393014091	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
65393014092	motif II; other site
65393014093	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
65393014094	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393014095	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
65393014096	Probable transposase; Region: OrfB_IS605; pfam01385
65393014097	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393014098	Archaeal ATPase; Region: Arch_ATPase; pfam01637
65393014099	AAA ATPase domain; Region: AAA_16; pfam13191
65393014100	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
65393014101	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
65393014102	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
65393014103	AAA ATPase domain; Region: AAA_16; pfam13191
65393014104	AAA domain; Region: AAA_22; pfam13401
65393014105	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
65393014106	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
65393014107	Substrate binding site; other site
65393014108	Mg++ binding site; other site
65393014109	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
65393014110	active site
65393014111	substrate binding site [chemical binding]; other site
65393014112	CoA binding site [chemical binding]; other site
65393014113	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
65393014114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393014115	active site
65393014116	phosphorylation site [posttranslational modification]
65393014117	intermolecular recognition site; other site
65393014118	dimerization interface [polypeptide binding]; other site
65393014119	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
65393014120	Zn2+ binding site [ion binding]; other site
65393014121	Mg2+ binding site [ion binding]; other site
65393014122	Uncharacterized conserved protein [Function unknown]; Region: COG4121
65393014123	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
65393014124	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393014125	Probable transposase; Region: OrfB_IS605; pfam01385
65393014126	cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153
65393014127	cyanoexosortase A; Region: cyanoexo_CrtA; TIGR03763
65393014128	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
65393014129	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
65393014130	putative ADP-binding pocket [chemical binding]; other site
65393014131	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393014132	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
65393014133	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393014134	NAD(P) binding site [chemical binding]; other site
65393014135	active site
65393014136	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
65393014137	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
65393014138	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65393014139	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
65393014140	DXD motif; other site
65393014141	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65393014142	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65393014143	active site
65393014144	Bacterial sugar transferase; Region: Bac_transf; pfam02397
65393014145	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
65393014146	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
65393014147	Probable Catalytic site; other site
65393014148	metal-binding site
65393014149	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
65393014150	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
65393014151	trimer interface [polypeptide binding]; other site
65393014152	active site
65393014153	substrate binding site [chemical binding]; other site
65393014154	CoA binding site [chemical binding]; other site
65393014155	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
65393014156	FAD binding domain; Region: FAD_binding_4; pfam01565
65393014157	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
65393014158	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
65393014159	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
65393014160	ribosomal protein L32; Validated; Region: rpl32; CHL00152
65393014161	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
65393014162	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
65393014163	Moco binding site; other site
65393014164	metal coordination site [ion binding]; other site
65393014165	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
65393014166	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
65393014167	active site
65393014168	dimer interface [polypeptide binding]; other site
65393014169	metal binding site [ion binding]; metal-binding site
65393014170	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
65393014171	TIR domain; Region: TIR_2; pfam13676
65393014172	TIR domain; Region: TIR_2; pfam13676
65393014173	TIR domain; Region: TIR_2; pfam13676
65393014174	TIR domain; Region: TIR_2; pfam13676
65393014175	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393014176	WD domain, G-beta repeat; Region: WD40; pfam00400
65393014177	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393014178	structural tetrad; other site
65393014179	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393014180	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393014181	structural tetrad; other site
65393014182	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393014183	structural tetrad; other site
65393014184	XisH protein; Region: XisH; pfam08814
65393014185	XisI protein; Region: XisI; pfam08869
65393014186	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393014187	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
65393014188	Uncharacterized conserved protein [Function unknown]; Region: COG2442
65393014189	Protein of unknown function DUF82; Region: DUF82; pfam01927
65393014190	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
65393014191	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
65393014192	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
65393014193	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
65393014194	hydroxyglutarate oxidase; Provisional; Region: PRK11728
65393014195	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
65393014196	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
65393014197	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
65393014198	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393014199	S-adenosylmethionine binding site [chemical binding]; other site
65393014200	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
65393014201	Family of unknown function (DUF490); Region: DUF490; pfam04357
65393014202	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
65393014203	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
65393014204	active site
65393014205	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
65393014206	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
65393014207	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
65393014208	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
65393014209	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
65393014210	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
65393014211	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393014212	Walker A/P-loop; other site
65393014213	ATP binding site [chemical binding]; other site
65393014214	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
65393014215	active site
65393014216	catalytic residues [active]
65393014217	Hemerythrin-like domain; Region: Hr-like; cd12108
65393014218	Fe binding site [ion binding]; other site
65393014219	CAAX protease self-immunity; Region: Abi; pfam02517
65393014220	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
65393014221	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
65393014222	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
65393014223	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
65393014224	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393014225	S-adenosylmethionine binding site [chemical binding]; other site
65393014226	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
65393014227	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
65393014228	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
65393014229	Catalytic site [active]
65393014230	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
65393014231	dimer interface [polypeptide binding]; other site
65393014232	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
65393014233	putative radical transfer pathway; other site
65393014234	diiron center [ion binding]; other site
65393014235	tyrosyl radical; other site
65393014236	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393014237	Domain of unknown function DUF29; Region: DUF29; pfam01724
65393014238	ATP cone domain; Region: ATP-cone; pfam03477
65393014239	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
65393014240	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
65393014241	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
65393014242	protein-splicing catalytic site; other site
65393014243	thioester formation/cholesterol transfer; other site
65393014244	Ribonucleotide reductase, alpha subunit [Nucleotide transport and metabolism]; Region: NrdA; COG0209
65393014245	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
65393014246	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
65393014247	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
65393014248	dimerization interface [polypeptide binding]; other site
65393014249	putative ATP binding site [chemical binding]; other site
65393014250	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
65393014251	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
65393014252	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
65393014253	Pantoate-beta-alanine ligase; Region: PanC; cd00560
65393014254	active site
65393014255	ATP-binding site [chemical binding]; other site
65393014256	pantoate-binding site; other site
65393014257	HXXH motif; other site
65393014258	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
65393014259	CMP-binding site; other site
65393014260	The sites determining sugar specificity; other site
65393014261	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
65393014262	homotrimer interaction site [polypeptide binding]; other site
65393014263	active site
65393014264	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
65393014265	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
65393014266	tandem repeat interface [polypeptide binding]; other site
65393014267	oligomer interface [polypeptide binding]; other site
65393014268	active site residues [active]
65393014269	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
65393014270	EamA-like transporter family; Region: EamA; pfam00892
65393014271	EamA-like transporter family; Region: EamA; pfam00892
65393014272	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
65393014273	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
65393014274	putative acyl-acceptor binding pocket; other site
65393014275	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
65393014276	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
65393014277	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
65393014278	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
65393014279	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
65393014280	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
65393014281	Cysteine-rich domain; Region: CCG; pfam02754
65393014282	Cysteine-rich domain; Region: CCG; pfam02754
65393014283	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
65393014284	FAD binding domain; Region: FAD_binding_4; pfam01565
65393014285	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
65393014286	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
65393014287	nucleotide binding site [chemical binding]; other site
65393014288	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
65393014289	active site
65393014290	catalytic residues [active]
65393014291	metal binding site [ion binding]; metal-binding site
65393014292	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
65393014293	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393014294	Probable transposase; Region: OrfB_IS605; pfam01385
65393014295	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
65393014296	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
65393014297	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
65393014298	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
65393014299	active site
65393014300	DNA binding site [nucleotide binding]
65393014301	Int/Topo IB signature motif; other site
65393014302	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393014303	putative active site [active]
65393014304	PIN domain; Region: PIN_3; pfam13470
65393014305	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
65393014306	TrwC relaxase; Region: TrwC; pfam08751
65393014307	AAA domain; Region: AAA_30; pfam13604
65393014308	AAA domain; Region: AAA_22; pfam13401
65393014309	Family description; Region: UvrD_C_2; pfam13538
65393014310	AAA domain; Region: AAA_11; pfam13086
65393014311	Part of AAA domain; Region: AAA_19; pfam13245
65393014312	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
65393014313	AAA domain; Region: AAA_30; pfam13604
65393014314	AAA domain; Region: AAA_12; pfam13087
65393014315	ParB-like nuclease domain; Region: ParBc; pfam02195
65393014316	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
65393014317	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65393014318	P-loop; other site
65393014319	Magnesium ion binding site [ion binding]; other site
65393014320	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65393014321	Magnesium ion binding site [ion binding]; other site
65393014322	seryl-tRNA synthetase; Provisional; Region: PRK05431
65393014323	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
65393014324	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
65393014325	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
65393014326	Fatty acid desaturase; Region: FA_desaturase; pfam00487
65393014327	Di-iron ligands [ion binding]; other site
65393014328	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65393014329	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65393014330	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
65393014331	active site
65393014332	catalytic residues [active]
65393014333	DNA binding site [nucleotide binding]
65393014334	Int/Topo IB signature motif; other site
65393014335	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014336	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393014337	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393014338	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014339	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014340	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014341	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
65393014342	Fasciclin domain; Region: Fasciclin; pfam02469
65393014343	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65393014344	non-specific DNA binding site [nucleotide binding]; other site
65393014345	salt bridge; other site
65393014346	sequence-specific DNA binding site [nucleotide binding]; other site
65393014347	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
65393014348	polymerase nucleotide-binding site; other site
65393014349	DNA-binding residues [nucleotide binding]; DNA binding site
65393014350	nucleotide binding site [chemical binding]; other site
65393014351	primase nucleotide-binding site [nucleotide binding]; other site
65393014352	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
65393014353	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
65393014354	TIR domain; Region: TIR_2; pfam13676
65393014355	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
65393014356	Catalytic NodB homology domain of uncharacterized chitin deacetylases and hypothetical proteins; Region: CE4_NodB_like_2; cd10958
65393014357	NodB motif; other site
65393014358	putative active site [active]
65393014359	putative catalytic site [active]
65393014360	TIR domain; Region: TIR_2; pfam13676
65393014361	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
65393014362	active site
65393014363	metal binding site [ion binding]; metal-binding site
65393014364	interdomain interaction site; other site
65393014365	D5 N terminal like; Region: D5_N; smart00885
65393014366	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
65393014367	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
65393014368	active site
65393014369	DNA binding site [nucleotide binding]
65393014370	Int/Topo IB signature motif; other site
65393014371	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
65393014372	putative active site [active]
65393014373	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393014374	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
65393014375	Walker A motif; other site
65393014376	ATP binding site [chemical binding]; other site
65393014377	Walker B motif; other site
65393014378	arginine finger; other site
65393014379	Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916
65393014380	TIR domain; Region: TIR_2; pfam13676
65393014381	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
65393014382	DNA binding residues [nucleotide binding]
65393014383	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
65393014384	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
65393014385	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
65393014386	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
65393014387	putative metal binding site [ion binding]; other site
65393014388	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
65393014389	active site
65393014390	nucleophile elbow; other site
65393014391	FHA domain; Region: FHA; pfam00498
65393014392	phosphopeptide binding site; other site
65393014393	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393014394	active site
65393014395	ATP binding site [chemical binding]; other site
65393014396	substrate binding site [chemical binding]; other site
65393014397	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
65393014398	activation loop (A-loop); other site
65393014399	activation loop (A-loop); other site
65393014400	Bacterial SH3 domain; Region: SH3_3; pfam08239
65393014401	MobA/MobL family; Region: MobA_MobL; pfam03389
65393014402	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
65393014403	GIY-YIG motif/motif A; other site
65393014404	active site
65393014405	catalytic site [active]
65393014406	metal binding site [ion binding]; metal-binding site
65393014407	Helix-turn-helix domain; Region: HTH_17; pfam12728
65393014408	Helix-turn-helix domain; Region: HTH_17; pfam12728
65393014409	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
65393014410	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
65393014411	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
65393014412	active site
65393014413	DNA binding site [nucleotide binding]
65393014414	Int/Topo IB signature motif; other site
65393014415	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
65393014416	active site
65393014417	metal binding site [ion binding]; metal-binding site
65393014418	interdomain interaction site; other site
65393014419	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
65393014420	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
65393014421	Walker A motif; other site
65393014422	ATP binding site [chemical binding]; other site
65393014423	Walker B motif; other site
65393014424	MobA/MobL family; Region: MobA_MobL; pfam03389
65393014425	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
65393014426	core dimer interface [polypeptide binding]; other site
65393014427	L11 interface [polypeptide binding]; other site
65393014428	putative EF-Tu interaction site [polypeptide binding]; other site
65393014429	putative EF-G interaction site [polypeptide binding]; other site
65393014430	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
65393014431	GIY-YIG motif/motif A; other site
65393014432	active site
65393014433	catalytic site [active]
65393014434	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
65393014435	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
65393014436	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
65393014437	active site
65393014438	DNA binding site [nucleotide binding]
65393014439	Int/Topo IB signature motif; other site
65393014440	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
65393014441	Putative serine esterase (DUF676); Region: DUF676; pfam05057
65393014442	AAA ATPase domain; Region: AAA_16; pfam13191
65393014443	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
65393014444	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393014445	structural tetrad; other site
65393014446	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393014447	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393014448	structural tetrad; other site
65393014449	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
65393014450	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
65393014451	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
65393014452	active site
65393014453	DNA binding site [nucleotide binding]
65393014454	Int/Topo IB signature motif; other site
65393014455	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65393014456	non-specific DNA binding site [nucleotide binding]; other site
65393014457	salt bridge; other site
65393014458	sequence-specific DNA binding site [nucleotide binding]; other site
65393014459	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
65393014460	Class I aldolases; Region: Aldolase_Class_I; cl17187
65393014461	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
65393014462	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
65393014463	Helix-turn-helix domain; Region: HTH_28; pfam13518
65393014464	Integrase core domain; Region: rve; pfam00665
65393014465	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
65393014466	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393014467	AAA domain; Region: AAA_22; pfam13401
65393014468	Walker A/P-loop; other site
65393014469	ATP binding site [chemical binding]; other site
65393014470	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
65393014471	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
65393014472	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
65393014473	PIN domain; Region: PIN_2; pfam10130
65393014474	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393014475	PIN domain; Region: PIN_2; cl17859
65393014476	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
65393014477	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
65393014478	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
65393014479	non-specific DNA binding site [nucleotide binding]; other site
65393014480	salt bridge; other site
65393014481	sequence-specific DNA binding site [nucleotide binding]; other site
65393014482	Double zinc ribbon; Region: DZR; pfam12773
65393014483	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
65393014484	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
65393014485	active site
65393014486	DNA binding site [nucleotide binding]
65393014487	Int/Topo IB signature motif; other site
65393014488	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393014489	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393014490	structural tetrad; other site
65393014491	FOG: WD40 repeat [General function prediction only]; Region: COG2319
65393014492	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
65393014493	structural tetrad; other site
65393014494	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
65393014495	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
65393014496	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
65393014497	LemA family; Region: LemA; cl00742
65393014498	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
65393014499	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393014500	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393014501	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393014502	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
65393014503	CHAT domain; Region: CHAT; cl17868
65393014504	AAA ATPase domain; Region: AAA_16; pfam13191
65393014505	GUN4-like; Region: GUN4; pfam05419
65393014506	Peptidase family M48; Region: Peptidase_M48; cl12018
65393014507	AMOP domain; Region: AMOP; cl02758
65393014508	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
65393014509	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
65393014510	dimer interface [polypeptide binding]; other site
65393014511	ssDNA binding site [nucleotide binding]; other site
65393014512	tetramer (dimer of dimers) interface [polypeptide binding]; other site
65393014513	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
65393014514	RNA/DNA hybrid binding site [nucleotide binding]; other site
65393014515	active site
65393014516	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
65393014517	active site
65393014518	RNA/DNA hybrid binding site [nucleotide binding]; other site
65393014519	Divergent AAA domain; Region: AAA_4; pfam04326
65393014520	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
65393014521	Mg binding site [ion binding]; other site
65393014522	nucleotide binding site [chemical binding]; other site
65393014523	putative protofilament interface [polypeptide binding]; other site
65393014524	GUN4-like; Region: GUN4; pfam05419
65393014525	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
65393014526	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
65393014527	DDE superfamily endonuclease; Region: DDE_5; cl17874
65393014528	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393014529	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
65393014530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393014531	active site
65393014532	phosphorylation site [posttranslational modification]
65393014533	intermolecular recognition site; other site
65393014534	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393014535	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
65393014536	Walker A motif; other site
65393014537	ATP binding site [chemical binding]; other site
65393014538	Walker B motif; other site
65393014539	arginine finger; other site
65393014540	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
65393014541	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
65393014542	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393014543	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393014544	DNA binding residues [nucleotide binding]
65393014545	dimerization interface [polypeptide binding]; other site
65393014546	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
65393014547	DdrB-like protein; Region: DdrB; pfam12747
65393014548	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
65393014549	Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399
65393014550	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
65393014551	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
65393014552	Surface antigen; Region: Bac_surface_Ag; pfam01103
65393014553	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
65393014554	haemagglutination activity domain; Region: Haemagg_act; pfam05860
65393014555	CHAT domain; Region: CHAT; cl17868
65393014556	CHASE2 domain; Region: CHASE2; pfam05226
65393014557	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
65393014558	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
65393014559	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
65393014560	ParB-like nuclease domain; Region: ParBc; pfam02195
65393014561	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
65393014562	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65393014563	P-loop; other site
65393014564	Magnesium ion binding site [ion binding]; other site
65393014565	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65393014566	Magnesium ion binding site [ion binding]; other site
65393014567	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
65393014568	polymerase nucleotide-binding site; other site
65393014569	DNA-binding residues [nucleotide binding]; DNA binding site
65393014570	nucleotide binding site [chemical binding]; other site
65393014571	primase nucleotide-binding site [nucleotide binding]; other site
65393014572	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
65393014573	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
65393014574	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
65393014575	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
65393014576	DEAD-like helicases superfamily; Region: DEXDc; smart00487
65393014577	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
65393014578	ATP binding site [chemical binding]; other site
65393014579	putative Mg++ binding site [ion binding]; other site
65393014580	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
65393014581	nucleotide binding region [chemical binding]; other site
65393014582	ATP-binding site [chemical binding]; other site
65393014583	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
65393014584	DNA polymerase III subunit beta; Validated; Region: PRK05643
65393014585	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
65393014586	putative DNA binding surface [nucleotide binding]; other site
65393014587	dimer interface [polypeptide binding]; other site
65393014588	beta-clamp/clamp loader binding surface; other site
65393014589	beta-clamp/translesion DNA polymerase binding surface; other site
65393014590	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
65393014591	DNA polymerase III subunit delta'; Validated; Region: PRK08485
65393014592	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
65393014593	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
65393014594	DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417
65393014595	active site
65393014596	catalytic site [active]
65393014597	substrate binding site [chemical binding]; other site
65393014598	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023
65393014599	active site
65393014600	metal-binding site
65393014601	DNA polymerase III subunit delta; Validated; Region: PRK07452
65393014602	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
65393014603	DNA polymerase III subunit delta'; Validated; Region: PRK07399
65393014604	DNA polymerase III subunit delta'; Validated; Region: PRK08485
65393014605	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393014606	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
65393014607	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
65393014608	Probable transposase; Region: OrfB_IS605; pfam01385
65393014609	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
65393014610	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
65393014611	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
65393014612	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
65393014613	putative active site [active]
65393014614	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
65393014615	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
65393014616	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
65393014617	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl11892
65393014618	CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cl11893
65393014619	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
65393014620	DEAD-like helicases superfamily; Region: DEXDc; smart00487
65393014621	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
65393014622	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
65393014623	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09703
65393014624	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467; cl01853
65393014625	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
65393014626	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393014627	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393014628	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393014629	AAA domain; Region: AAA_31; pfam13614
65393014630	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65393014631	P-loop; other site
65393014632	Magnesium ion binding site [ion binding]; other site
65393014633	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65393014634	Magnesium ion binding site [ion binding]; other site
65393014635	KilA-N domain; Region: KilA-N; pfam04383
65393014636	Endonuclease I; Region: Endonuclease_1; pfam04231
65393014637	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
65393014638	classical (c) SDRs; Region: SDR_c; cd05233
65393014639	NAD(P) binding site [chemical binding]; other site
65393014640	active site
65393014641	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
65393014642	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
65393014643	active site
65393014644	DNA binding site [nucleotide binding]
65393014645	Int/Topo IB signature motif; other site
65393014646	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
65393014647	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
65393014648	AAA-like domain; Region: AAA_10; pfam12846
65393014649	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
65393014650	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
65393014651	active site
65393014652	metal binding site [ion binding]; metal-binding site
65393014653	D5 N terminal like; Region: D5_N; pfam08706
65393014654	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
65393014655	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
65393014656	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
65393014657	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393014658	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393014659	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393014660	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
65393014661	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
65393014662	Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399
65393014663	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
65393014664	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
65393014665	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
65393014666	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
65393014667	DNA binding residues [nucleotide binding]
65393014668	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
65393014669	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
65393014670	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
65393014671	Surface antigen; Region: Bac_surface_Ag; pfam01103
65393014672	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
65393014673	haemagglutination activity domain; Region: Haemagg_act; pfam05860
65393014674	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
65393014675	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393014676	binding surface
65393014677	TPR motif; other site
65393014678	CHAT domain; Region: CHAT; cl17868
65393014679	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
65393014680	CHASE2 domain; Region: CHASE2; pfam05226
65393014681	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
65393014682	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393014683	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393014684	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393014685	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
65393014686	Helix-turn-helix domain; Region: HTH_28; pfam13518
65393014687	DDE superfamily endonuclease; Region: DDE_3; pfam13358
65393014688	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
65393014689	TIR domain; Region: TIR_2; pfam13676
65393014690	YCII-related domain; Region: YCII; cl00999
65393014691	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
65393014692	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393014693	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393014694	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393014695	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
65393014696	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393014697	Walker A motif; other site
65393014698	ATP binding site [chemical binding]; other site
65393014699	Walker B motif; other site
65393014700	arginine finger; other site
65393014701	DNA polymerase III subunit delta; Validated; Region: PRK07452
65393014702	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
65393014703	PIN domain; Region: PIN_3; pfam13470
65393014704	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393014705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
65393014706	active site
65393014707	phosphorylation site [posttranslational modification]
65393014708	intermolecular recognition site; other site
65393014709	dimerization interface [polypeptide binding]; other site
65393014710	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393014711	DNA binding residues [nucleotide binding]
65393014712	dimerization interface [polypeptide binding]; other site
65393014713	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
65393014714	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393014715	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393014716	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393014717	DdrB-like protein; Region: DdrB; pfam12747
65393014718	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
65393014719	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
65393014720	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
65393014721	DNA binding residues [nucleotide binding]
65393014722	dimerization interface [polypeptide binding]; other site
65393014723	AAA-like domain; Region: AAA_10; pfam12846
65393014724	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
65393014725	endonuclease III; Region: ENDO3c; smart00478
65393014726	minor groove reading motif; other site
65393014727	helix-hairpin-helix signature motif; other site
65393014728	substrate binding pocket [chemical binding]; other site
65393014729	active site
65393014730	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
65393014731	ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...; Region: ASRGL1_like; cd04702
65393014732	catalytic nucleophile [active]
65393014733	ATP-grasp domain; Region: ATP-grasp_4; cl17255
65393014734	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393014735	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
65393014736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
65393014737	active site
65393014738	phosphorylation site [posttranslational modification]
65393014739	intermolecular recognition site; other site
65393014740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
65393014741	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
65393014742	Walker A motif; other site
65393014743	ATP binding site [chemical binding]; other site
65393014744	Walker B motif; other site
65393014745	arginine finger; other site
65393014746	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
65393014747	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
65393014748	Transposase [DNA replication, recombination, and repair]; Region: COG5421
65393014749	Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229
65393014750	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
65393014751	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
65393014752	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
65393014753	active site
65393014754	Int/Topo IB signature motif; other site
65393014755	DNA binding site [nucleotide binding]
65393014756	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393014757	short chain dehydrogenase; Provisional; Region: PRK06181
65393014758	NAD(P) binding site [chemical binding]; other site
65393014759	active site
65393014760	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
65393014761	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
65393014762	putative NAD(P) binding site [chemical binding]; other site
65393014763	putative substrate binding site [chemical binding]; other site
65393014764	catalytic Zn binding site [ion binding]; other site
65393014765	structural Zn binding site [ion binding]; other site
65393014766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393014767	S-adenosylmethionine binding site [chemical binding]; other site
65393014768	Uncharacterized conserved protein [Function unknown]; Region: COG2128
65393014769	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
65393014770	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65393014771	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65393014772	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
65393014773	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
65393014774	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
65393014775	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
65393014776	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
65393014777	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
65393014778	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393014779	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
65393014780	HEAT repeats; Region: HEAT_2; pfam13646
65393014781	HEAT repeats; Region: HEAT_2; pfam13646
65393014782	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
65393014783	HEAT repeats; Region: HEAT_2; pfam13646
65393014784	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
65393014785	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
65393014786	CpeS-like protein; Region: CpeS; pfam09367
65393014787	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65393014788	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
65393014789	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
65393014790	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
65393014791	Phycobilisome protein; Region: Phycobilisome; cl08227
65393014792	HEAT repeats; Region: HEAT_2; pfam13646
65393014793	HEAT repeats; Region: HEAT_2; pfam13646
65393014794	HEAT repeats; Region: HEAT_2; pfam13646
65393014795	dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247
65393014796	phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13250
65393014797	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
65393014798	HEAT repeats; Region: HEAT_2; pfam13646
65393014799	protein binding surface [polypeptide binding]; other site
65393014800	HEAT repeats; Region: HEAT_2; pfam13646
65393014801	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
65393014802	HEAT repeats; Region: HEAT_2; pfam13646
65393014803	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
65393014804	Phycobilisome protein; Region: Phycobilisome; cl08227
65393014805	Phycobilisome protein; Region: Phycobilisome; cl08227
65393014806	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014807	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
65393014808	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014809	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014810	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014811	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
65393014812	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
65393014813	HicB family; Region: HicB; pfam05534
65393014814	CpeS-like protein; Region: CpeS; pfam09367
65393014815	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
65393014816	YcaO-like family; Region: YcaO; pfam02624
65393014817	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
65393014818	Amidohydrolase; Region: Amidohydro_2; pfam04909
65393014819	Protein kinase domain; Region: Pkinase; pfam00069
65393014820	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393014821	active site
65393014822	ATP binding site [chemical binding]; other site
65393014823	substrate binding site [chemical binding]; other site
65393014824	activation loop (A-loop); other site
65393014825	AAA ATPase domain; Region: AAA_16; pfam13191
65393014826	Predicted ATPase [General function prediction only]; Region: COG3899
65393014827	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
65393014828	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
65393014829	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
65393014830	Walker A motif; other site
65393014831	ATP binding site [chemical binding]; other site
65393014832	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
65393014833	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
65393014834	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
65393014835	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
65393014836	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
65393014837	Walker A/P-loop; other site
65393014838	ATP binding site [chemical binding]; other site
65393014839	Q-loop/lid; other site
65393014840	ABC transporter signature motif; other site
65393014841	Walker B; other site
65393014842	D-loop; other site
65393014843	H-loop/switch region; other site
65393014844	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
65393014845	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
65393014846	ABC-ATPase subunit  interface; other site
65393014847	dimer interface [polypeptide binding]; other site
65393014848	putative PBP binding regions; other site
65393014849	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
65393014850	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
65393014851	ABC-ATPase subunit  interface; other site
65393014852	dimer interface [polypeptide binding]; other site
65393014853	putative PBP binding regions; other site
65393014854	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
65393014855	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
65393014856	inhibitor-cofactor binding pocket; inhibition site
65393014857	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393014858	catalytic residue [active]
65393014859	Condensation domain; Region: Condensation; pfam00668
65393014860	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
65393014861	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
65393014862	acyl-activating enzyme (AAE) consensus motif; other site
65393014863	AMP binding site [chemical binding]; other site
65393014864	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393014865	thioester reductase domain; Region: Thioester-redct; TIGR01746
65393014866	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
65393014867	putative NAD(P) binding site [chemical binding]; other site
65393014868	active site
65393014869	putative substrate binding site [chemical binding]; other site
65393014870	Condensation domain; Region: Condensation; pfam00668
65393014871	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393014872	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
65393014873	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
65393014874	acyl-activating enzyme (AAE) consensus motif; other site
65393014875	AMP binding site [chemical binding]; other site
65393014876	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393014877	Condensation domain; Region: Condensation; pfam00668
65393014878	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
65393014879	Condensation domain; Region: Condensation; pfam00668
65393014880	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393014881	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
65393014882	acyl-activating enzyme (AAE) consensus motif; other site
65393014883	AMP binding site [chemical binding]; other site
65393014884	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393014885	Condensation domain; Region: Condensation; pfam00668
65393014886	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
65393014887	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
65393014888	acyl-activating enzyme (AAE) consensus motif; other site
65393014889	AMP binding site [chemical binding]; other site
65393014890	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393014891	Condensation domain; Region: Condensation; pfam00668
65393014892	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393014893	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
65393014894	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
65393014895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393014896	S-adenosylmethionine binding site [chemical binding]; other site
65393014897	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
65393014898	Condensation domain; Region: Condensation; pfam00668
65393014899	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
65393014900	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
65393014901	acyl-activating enzyme (AAE) consensus motif; other site
65393014902	AMP binding site [chemical binding]; other site
65393014903	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393014904	Condensation domain; Region: Condensation; pfam00668
65393014905	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393014906	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
65393014907	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
65393014908	acyl-activating enzyme (AAE) consensus motif; other site
65393014909	AMP binding site [chemical binding]; other site
65393014910	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393014911	Condensation domain; Region: Condensation; pfam00668
65393014912	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393014913	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
65393014914	acyl-CoA synthetase; Validated; Region: PRK05850
65393014915	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
65393014916	acyl-activating enzyme (AAE) consensus motif; other site
65393014917	active site
65393014918	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
65393014919	Condensation domain; Region: Condensation; pfam00668
65393014920	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393014921	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
65393014922	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
65393014923	acyl-activating enzyme (AAE) consensus motif; other site
65393014924	AMP binding site [chemical binding]; other site
65393014925	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65393014926	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393014927	S-adenosylmethionine binding site [chemical binding]; other site
65393014928	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
65393014929	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393014930	Condensation domain; Region: Condensation; pfam00668
65393014931	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393014932	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
65393014933	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
65393014934	AMIN domain; Region: AMIN; pfam11741
65393014935	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
65393014936	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
65393014937	N-terminal plug; other site
65393014938	ligand-binding site [chemical binding]; other site
65393014939	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
65393014940	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
65393014941	siderophore binding site; other site
65393014942	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
65393014943	putative dimer interface [polypeptide binding]; other site
65393014944	putative [2Fe-2S] cluster binding site [ion binding]; other site
65393014945	Cupin-like domain; Region: Cupin_8; pfam13621
65393014946	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65393014947	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393014948	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393014949	Walker A/P-loop; other site
65393014950	ATP binding site [chemical binding]; other site
65393014951	Q-loop/lid; other site
65393014952	ABC transporter signature motif; other site
65393014953	Walker B; other site
65393014954	D-loop; other site
65393014955	H-loop/switch region; other site
65393014956	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65393014957	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393014958	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
65393014959	Walker A/P-loop; other site
65393014960	ATP binding site [chemical binding]; other site
65393014961	Q-loop/lid; other site
65393014962	ABC transporter signature motif; other site
65393014963	Walker B; other site
65393014964	D-loop; other site
65393014965	H-loop/switch region; other site
65393014966	Penicillin amidase; Region: Penicil_amidase; pfam01804
65393014967	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
65393014968	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
65393014969	active site
65393014970	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
65393014971	Helix-turn-helix domain; Region: HTH_28; pfam13518
65393014972	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393014973	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
65393014974	Chain length determinant protein; Region: Wzz; pfam02706
65393014975	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
65393014976	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
65393014977	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
65393014978	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
65393014979	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
65393014980	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
65393014981	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
65393014982	Walker A/P-loop; other site
65393014983	ATP binding site [chemical binding]; other site
65393014984	Q-loop/lid; other site
65393014985	ABC transporter signature motif; other site
65393014986	Walker B; other site
65393014987	D-loop; other site
65393014988	H-loop/switch region; other site
65393014989	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
65393014990	putative carbohydrate binding site [chemical binding]; other site
65393014991	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
65393014992	putative trimer interface [polypeptide binding]; other site
65393014993	putative active site [active]
65393014994	putative substrate binding site [chemical binding]; other site
65393014995	putative CoA binding site [chemical binding]; other site
65393014996	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
65393014997	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
65393014998	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
65393014999	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
65393015000	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
65393015001	inhibitor-cofactor binding pocket; inhibition site
65393015002	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393015003	catalytic residue [active]
65393015004	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
65393015005	trimer interface [polypeptide binding]; other site
65393015006	active site
65393015007	substrate binding site [chemical binding]; other site
65393015008	CoA binding site [chemical binding]; other site
65393015009	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
65393015010	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
65393015011	NAD(P) binding site [chemical binding]; other site
65393015012	active site
65393015013	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
65393015014	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
65393015015	inhibitor-cofactor binding pocket; inhibition site
65393015016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
65393015017	catalytic residue [active]
65393015018	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
65393015019	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
65393015020	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
65393015021	Ligand binding site; other site
65393015022	metal-binding site
65393015023	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65393015024	active site
65393015025	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65393015026	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65393015027	active site
65393015028	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65393015029	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65393015030	active site
65393015031	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
65393015032	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
65393015033	active site
65393015034	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65393015035	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393015036	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393015037	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65393015038	Exostosin family; Region: Exostosin; pfam03016
65393015039	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393015040	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
65393015041	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
65393015042	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
65393015043	active site
65393015044	dimer interface [polypeptide binding]; other site
65393015045	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
65393015046	Ligand Binding Site [chemical binding]; other site
65393015047	Molecular Tunnel; other site
65393015048	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393015049	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
65393015050	putative ADP-binding pocket [chemical binding]; other site
65393015051	Methyltransferase domain; Region: Methyltransf_23; pfam13489
65393015052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393015053	S-adenosylmethionine binding site [chemical binding]; other site
65393015054	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
65393015055	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
65393015056	putative metal binding site; other site
65393015057	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
65393015058	S-adenosylmethionine binding site [chemical binding]; other site
65393015059	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
65393015060	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
65393015061	Homeodomain-like domain; Region: HTH_23; pfam13384
65393015062	Winged helix-turn helix; Region: HTH_29; pfam13551
65393015063	Homeodomain-like domain; Region: HTH_32; pfam13565
65393015064	Integrase core domain; Region: rve; pfam00665
65393015065	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
65393015066	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393015067	DDE superfamily endonuclease; Region: DDE_4; pfam13359
65393015068	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
65393015069	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
65393015070	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393015071	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393015072	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393015073	Tetratricopeptide repeat; Region: TPR_12; pfam13424
65393015074	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
65393015075	binding surface
65393015076	TPR motif; other site
65393015077	CHAT domain; Region: CHAT; cl17868
65393015078	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
65393015079	CHASE2 domain; Region: CHASE2; pfam05226
65393015080	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
65393015081	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
65393015082	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
65393015083	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
65393015084	ATP binding site [chemical binding]; other site
65393015085	Mg2+ binding site [ion binding]; other site
65393015086	G-X-G motif; other site
65393015087	Uncharacterized conserved protein [Function unknown]; Region: COG5464
65393015088	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
65393015089	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
65393015090	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
65393015091	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393015092	DDE superfamily endonuclease; Region: DDE_4; pfam13359
65393015093	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
65393015094	high affinity sulphate transporter 1; Region: sulP; TIGR00815
65393015095	Sulfate transporter family; Region: Sulfate_transp; pfam00916
65393015096	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
65393015097	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
65393015098	Catalytic domain of Protein Kinases; Region: PKc; cd00180
65393015099	active site
65393015100	ATP binding site [chemical binding]; other site
65393015101	substrate binding site [chemical binding]; other site
65393015102	activation loop (A-loop); other site
65393015103	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
65393015104	active site
65393015105	NTP binding site [chemical binding]; other site
65393015106	metal binding triad [ion binding]; metal-binding site
65393015107	antibiotic binding site [chemical binding]; other site
65393015108	Uncharacterized conserved protein [Function unknown]; Region: COG2361
65393015109	Homeodomain-like domain; Region: HTH_23; pfam13384
65393015110	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
65393015111	Homeodomain-like domain; Region: HTH_32; pfam13565
65393015112	Winged helix-turn helix; Region: HTH_33; pfam13592
65393015113	DDE superfamily endonuclease; Region: DDE_3; pfam13358
65393015114	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
65393015115	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
65393015116	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
65393015117	ParB-like nuclease domain; Region: ParBc; pfam02195
65393015118	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
65393015119	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65393015120	P-loop; other site
65393015121	Magnesium ion binding site [ion binding]; other site
65393015122	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
65393015123	Magnesium ion binding site [ion binding]; other site
65393015124	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
65393015125	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
65393015126	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
65393015127	Fe-S cluster binding site [ion binding]; other site
65393015128	active site
65393015129	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
65393015130	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
65393015131	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
65393015132	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393015133	Transposase [DNA replication, recombination, and repair]; Region: COG5433
65393015134	AAA domain; Region: AAA_30; pfam13604
65393015135	AAA domain; Region: AAA_22; pfam13401
65393015136	Family description; Region: UvrD_C_2; pfam13538
65393015137	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
65393015138	HD domain; Region: HD_4; pfam13328
65393015139	CRISPR-associated protein, TIGR03985 family; Region: TIGR03985
65393015140	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742
65393015141	putative regulator PrlF; Provisional; Region: PRK09974
65393015142	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
65393015143	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
65393015144	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
65393015145	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
65393015146	putative active site [active]
65393015147	putative NTP binding site [chemical binding]; other site
65393015148	putative nucleic acid binding site [nucleotide binding]; other site
65393015149	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
65393015150	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
65393015151	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
65393015152	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
65393015153	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
65393015154	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
65393015155	Helix-turn-helix domain; Region: HTH_28; pfam13518
65393015156	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
65393015157	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
65393015158	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
65393015159	Walker A/P-loop; other site
65393015160	ATP binding site [chemical binding]; other site
65393015161	Q-loop/lid; other site
65393015162	ABC transporter signature motif; other site
65393015163	Walker B; other site
65393015164	D-loop; other site
65393015165	H-loop/switch region; other site
65393015166	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
65393015167	Helix-turn-helix domain; Region: HTH_28; pfam13518
65393015168	DDE superfamily endonuclease; Region: DDE_3; pfam13358
65393015169	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
65393015170	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
65393015171	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393015172	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
65393015173	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393015174	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
65393015175	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
65393015176	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
65393015177	active site
65393015178	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
65393015179	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
65393015180	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
65393015181	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
65393015182	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
65393015183	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
65393015184	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
65393015185	acyl-activating enzyme (AAE) consensus motif; other site
65393015186	AMP binding site [chemical binding]; other site
65393015187	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393015188	Condensation domain; Region: Condensation; pfam00668
65393015189	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393015190	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
65393015191	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
65393015192	acyl-activating enzyme (AAE) consensus motif; other site
65393015193	AMP binding site [chemical binding]; other site
65393015194	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393015195	Condensation domain; Region: Condensation; pfam00668
65393015196	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393015197	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
65393015198	Condensation domain; Region: Condensation; pfam00668
65393015199	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393015200	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
65393015201	acyl-activating enzyme (AAE) consensus motif; other site
65393015202	AMP binding site [chemical binding]; other site
65393015203	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393015204	Condensation domain; Region: Condensation; pfam00668
65393015205	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393015206	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
65393015207	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
65393015208	acyl-activating enzyme (AAE) consensus motif; other site
65393015209	AMP binding site [chemical binding]; other site
65393015210	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
65393015211	Condensation domain; Region: Condensation; pfam00668
65393015212	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
65393015213	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
65393015214	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
65393015215	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
65393015216	Helix-turn-helix domain; Region: HTH_28; pfam13518
65393015217	DDE superfamily endonuclease; Region: DDE_3; pfam13358
65393015218	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
65393015219	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
65393015220	Helix-turn-helix domain; Region: HTH_28; pfam13518
65393015221	DDE superfamily endonuclease; Region: DDE_3; pfam13358
65393015222	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
65393015223	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
65393015224	DNA primase, catalytic core; Region: dnaG; TIGR01391
65393015225	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
65393015226	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
65393015227	active site
65393015228	metal binding site [ion binding]; metal-binding site
65393015229	D5 N terminal like; Region: D5_N; smart00885
65393015230	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
65393015231	DDE superfamily endonuclease; Region: DDE_5; cl17874
65393015232	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
65393015233	PemK-like protein; Region: PemK; pfam02452