-- dump date   	20140619_054727
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
395961000001	Response regulator receiver domain; Region: Response_reg; pfam00072
395961000002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961000003	active site
395961000004	phosphorylation site [posttranslational modification]
395961000005	intermolecular recognition site; other site
395961000006	dimerization interface [polypeptide binding]; other site
395961000007	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961000008	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961000009	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961000010	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961000011	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961000012	Histidine kinase; Region: HisKA_2; pfam07568
395961000013	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961000014	ATP binding site [chemical binding]; other site
395961000015	Mg2+ binding site [ion binding]; other site
395961000016	G-X-G motif; other site
395961000017	Cupin domain; Region: Cupin_2; cl17218
395961000018	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395961000019	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
395961000020	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395961000021	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
395961000022	Transmembrane protein; Region: Macoilin; pfam09726
395961000023	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
395961000024	putative ADP-ribose binding site [chemical binding]; other site
395961000025	putative active site [active]
395961000026	CHAT domain; Region: CHAT; cl17868
395961000027	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
395961000028	ADP-ribose binding site [chemical binding]; other site
395961000029	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
395961000030	Dynamin family; Region: Dynamin_N; pfam00350
395961000031	G1 box; other site
395961000032	GTP/Mg2+ binding site [chemical binding]; other site
395961000033	G2 box; other site
395961000034	Switch I region; other site
395961000035	G3 box; other site
395961000036	Switch II region; other site
395961000037	G4 box; other site
395961000038	G5 box; other site
395961000039	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
395961000040	Dynamin family; Region: Dynamin_N; pfam00350
395961000041	G1 box; other site
395961000042	GTP/Mg2+ binding site [chemical binding]; other site
395961000043	G2 box; other site
395961000044	Switch I region; other site
395961000045	G3 box; other site
395961000046	Switch II region; other site
395961000047	G4 box; other site
395961000048	G5 box; other site
395961000049	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
395961000050	CHAT domain; Region: CHAT; cl17868
395961000051	Transposase domain (DUF772); Region: DUF772; pfam05598
395961000052	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961000053	DDE superfamily endonuclease; Region: DDE_4; cl17710
395961000054	GUN4-like; Region: GUN4; pfam05419
395961000055	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961000056	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
395961000057	active site
395961000058	catalytic triad [active]
395961000059	oxyanion hole [active]
395961000060	transposase; Validated; Region: PRK08181
395961000061	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961000062	Walker A motif; other site
395961000063	ATP binding site [chemical binding]; other site
395961000064	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
395961000065	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
395961000066	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
395961000067	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
395961000068	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
395961000069	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
395961000070	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
395961000071	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961000072	putative active site [active]
395961000073	Winged helix-turn helix; Region: HTH_29; pfam13551
395961000074	Helix-turn-helix domain; Region: HTH_28; pfam13518
395961000075	Homeodomain-like domain; Region: HTH_32; pfam13565
395961000076	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961000077	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961000078	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
395961000079	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
395961000080	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
395961000081	helicase superfamily c-terminal domain; Region: HELICc; smart00490
395961000082	ATP-binding site [chemical binding]; other site
395961000083	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
395961000084	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
395961000085	Family description; Region: UvrD_C_2; pfam13538
395961000086	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
395961000087	DEAD-like helicases superfamily; Region: DEXDc; smart00487
395961000088	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961000089	ATP binding site [chemical binding]; other site
395961000090	putative Mg++ binding site [ion binding]; other site
395961000091	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
395961000092	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961000093	nucleotide binding region [chemical binding]; other site
395961000094	ATP-binding site [chemical binding]; other site
395961000095	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
395961000096	putative catalytic site [active]
395961000097	putative metal binding site [ion binding]; other site
395961000098	putative phosphate binding site [ion binding]; other site
395961000099	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
395961000100	DEAD-like helicases superfamily; Region: DEXDc; smart00487
395961000101	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961000102	ATP binding site [chemical binding]; other site
395961000103	putative Mg++ binding site [ion binding]; other site
395961000104	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961000105	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
395961000106	nucleotide binding region [chemical binding]; other site
395961000107	ATP-binding site [chemical binding]; other site
395961000108	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
395961000109	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395961000110	active site
395961000111	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
395961000112	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
395961000113	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
395961000114	active site
395961000115	substrate binding site [chemical binding]; other site
395961000116	catalytic site [active]
395961000117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395961000118	AAA domain; Region: AAA_22; pfam13401
395961000119	Walker A motif; other site
395961000120	ATP binding site [chemical binding]; other site
395961000121	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961000122	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
395961000123	AAA domain; Region: AAA_33; pfam13671
395961000124	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
395961000125	active site
395961000126	WYL domain; Region: WYL; pfam13280
395961000127	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961000128	ATP binding site [chemical binding]; other site
395961000129	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
395961000130	putative Mg++ binding site [ion binding]; other site
395961000131	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961000132	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961000133	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961000134	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
395961000135	putative catalytic site [active]
395961000136	putative metal binding site [ion binding]; other site
395961000137	putative phosphate binding site [ion binding]; other site
395961000138	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
395961000139	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
395961000140	Septum formation initiator; Region: DivIC; cl17659
395961000141	LabA_like proteins; Region: LabA; cd10911
395961000142	Uncharacterized conserved protein [Function unknown]; Region: COG1432
395961000143	putative metal binding site [ion binding]; other site
395961000144	Predicted transcriptional regulator [Transcription]; Region: COG2932
395961000145	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
395961000146	Catalytic site [active]
395961000147	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
395961000148	non-specific DNA binding site [nucleotide binding]; other site
395961000149	salt bridge; other site
395961000150	sequence-specific DNA binding site [nucleotide binding]; other site
395961000151	hypothetical protein; Provisional; Region: PRK10736
395961000152	YfdX protein; Region: YfdX; pfam10938
395961000153	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395961000154	nucleotide binding site [chemical binding]; other site
395961000155	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
395961000156	TrwC relaxase; Region: TrwC; pfam08751
395961000157	AAA domain; Region: AAA_30; pfam13604
395961000158	AAA domain; Region: AAA_22; pfam13401
395961000159	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
395961000160	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961000161	Methyltransferase domain; Region: Methyltransf_26; pfam13659
395961000162	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
395961000163	Helicase_C-like; Region: Helicase_C_4; pfam13871
395961000164	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961000165	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
395961000166	Walker A motif; other site
395961000167	ATP binding site [chemical binding]; other site
395961000168	Walker B motif; other site
395961000169	arginine finger; other site
395961000170	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
395961000171	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
395961000172	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
395961000173	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
395961000174	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
395961000175	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961000176	Coenzyme A binding pocket [chemical binding]; other site
395961000177	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
395961000178	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961000179	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
395961000180	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961000181	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961000182	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
395961000183	Peptidase family M23; Region: Peptidase_M23; pfam01551
395961000184	AAA-like domain; Region: AAA_10; pfam12846
395961000185	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
395961000186	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
395961000187	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
395961000188	DNA binding residues [nucleotide binding]
395961000189	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395961000190	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961000191	non-specific DNA binding site [nucleotide binding]; other site
395961000192	salt bridge; other site
395961000193	sequence-specific DNA binding site [nucleotide binding]; other site
395961000194	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
395961000195	active site
395961000196	metal binding site [ion binding]; metal-binding site
395961000197	interdomain interaction site; other site
395961000198	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
395961000199	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
395961000200	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395961000201	P-loop; other site
395961000202	Magnesium ion binding site [ion binding]; other site
395961000203	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395961000204	Magnesium ion binding site [ion binding]; other site
395961000205	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
395961000206	ParB-like nuclease domain; Region: ParBc; pfam02195
395961000207	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
395961000208	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
395961000209	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
395961000210	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
395961000211	RNA binding site [nucleotide binding]; other site
395961000212	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
395961000213	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
395961000214	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395961000215	putative NAD(P) binding site [chemical binding]; other site
395961000216	Predicted transcriptional regulators [Transcription]; Region: COG1733
395961000217	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395961000218	dimerization interface [polypeptide binding]; other site
395961000219	putative DNA binding site [nucleotide binding]; other site
395961000220	putative Zn2+ binding site [ion binding]; other site
395961000221	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
395961000222	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
395961000223	catalytic residues [active]
395961000224	catalytic nucleophile [active]
395961000225	Presynaptic Site I dimer interface [polypeptide binding]; other site
395961000226	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
395961000227	Synaptic Flat tetramer interface [polypeptide binding]; other site
395961000228	Synaptic Site I dimer interface [polypeptide binding]; other site
395961000229	DNA binding site [nucleotide binding]
395961000230	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
395961000231	DNA-binding interface [nucleotide binding]; DNA binding site
395961000232	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
395961000233	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
395961000234	Dienelactone hydrolase family; Region: DLH; pfam01738
395961000235	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395961000236	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961000237	active site
395961000238	phosphorylation site [posttranslational modification]
395961000239	intermolecular recognition site; other site
395961000240	dimerization interface [polypeptide binding]; other site
395961000241	Cupin domain; Region: Cupin_2; pfam07883
395961000242	tellurium resistance terB-like protein; Region: terB_like; cl11965
395961000243	metal binding site [ion binding]; metal-binding site
395961000244	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
395961000245	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
395961000246	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395961000247	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395961000248	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
395961000249	DDE superfamily endonuclease; Region: DDE_4; pfam13359
395961000250	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
395961000251	putative hydrophobic ligand binding site [chemical binding]; other site
395961000252	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
395961000253	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395961000254	NAD binding site [chemical binding]; other site
395961000255	catalytic Zn binding site [ion binding]; other site
395961000256	structural Zn binding site [ion binding]; other site
395961000257	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
395961000258	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395961000259	NAD binding site [chemical binding]; other site
395961000260	catalytic Zn binding site [ion binding]; other site
395961000261	structural Zn binding site [ion binding]; other site
395961000262	transposase; Validated; Region: PRK08181
395961000263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961000264	Walker A motif; other site
395961000265	ATP binding site [chemical binding]; other site
395961000266	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961000267	PAS fold; Region: PAS_3; pfam08447
395961000268	putative active site [active]
395961000269	heme pocket [chemical binding]; other site
395961000270	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961000271	Histidine kinase; Region: HisKA_2; pfam07568
395961000272	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961000273	ATP binding site [chemical binding]; other site
395961000274	Mg2+ binding site [ion binding]; other site
395961000275	G-X-G motif; other site
395961000276	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961000277	non-specific DNA binding site [nucleotide binding]; other site
395961000278	sequence-specific DNA binding site [nucleotide binding]; other site
395961000279	salt bridge; other site
395961000280	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961000281	non-specific DNA binding site [nucleotide binding]; other site
395961000282	sequence-specific DNA binding site [nucleotide binding]; other site
395961000283	salt bridge; other site
395961000284	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
395961000285	Protein kinase domain; Region: Pkinase; pfam00069
395961000286	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961000287	active site
395961000288	ATP binding site [chemical binding]; other site
395961000289	substrate binding site [chemical binding]; other site
395961000290	activation loop (A-loop); other site
395961000291	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395961000292	binding surface
395961000293	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
395961000294	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395961000295	PIN domain; Region: PIN_3; pfam13470
395961000296	ParA-like protein; Provisional; Region: PHA02518
395961000297	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395961000298	P-loop; other site
395961000299	Magnesium ion binding site [ion binding]; other site
395961000300	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
395961000301	active site
395961000302	catalytic residues [active]
395961000303	DNA binding site [nucleotide binding]
395961000304	Int/Topo IB signature motif; other site
395961000305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961000306	non-specific DNA binding site [nucleotide binding]; other site
395961000307	salt bridge; other site
395961000308	sequence-specific DNA binding site [nucleotide binding]; other site
395961000309	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
395961000310	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
395961000311	active site
395961000312	metal binding site [ion binding]; metal-binding site
395961000313	interdomain interaction site; other site
395961000314	Methyltransferase domain; Region: Methyltransf_26; pfam13659
395961000315	HerA helicase [Replication, recombination, and repair]; Region: COG0433
395961000316	Domain of unknown function DUF87; Region: DUF87; pfam01935
395961000317	Zonular occludens toxin (Zot); Region: Zot; cl17485
395961000318	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
395961000319	DnaA N-terminal domain; Region: DnaA_N; pfam11638
395961000320	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961000321	Walker A motif; other site
395961000322	ATP binding site [chemical binding]; other site
395961000323	Walker B motif; other site
395961000324	arginine finger; other site
395961000325	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
395961000326	DnaA box-binding interface [nucleotide binding]; other site
395961000327	DNA polymerase III subunit beta; Validated; Region: PRK05643
395961000328	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
395961000329	putative DNA binding surface [nucleotide binding]; other site
395961000330	dimer interface [polypeptide binding]; other site
395961000331	beta-clamp/clamp loader binding surface; other site
395961000332	beta-clamp/translesion DNA polymerase binding surface; other site
395961000333	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
395961000334	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395961000335	Amidohydrolase; Region: Amidohydro_2; pfam04909
395961000336	GAF domain; Region: GAF; cl17456
395961000337	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961000338	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961000339	dimer interface [polypeptide binding]; other site
395961000340	phosphorylation site [posttranslational modification]
395961000341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961000342	ATP binding site [chemical binding]; other site
395961000343	Mg2+ binding site [ion binding]; other site
395961000344	G-X-G motif; other site
395961000345	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
395961000346	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
395961000347	dimer interface [polypeptide binding]; other site
395961000348	[2Fe-2S] cluster binding site [ion binding]; other site
395961000349	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
395961000350	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
395961000351	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
395961000352	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961000353	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961000354	ligand binding site [chemical binding]; other site
395961000355	flexible hinge region; other site
395961000356	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395961000357	non-specific DNA interactions [nucleotide binding]; other site
395961000358	DNA binding site [nucleotide binding]
395961000359	sequence specific DNA binding site [nucleotide binding]; other site
395961000360	putative cAMP binding site [chemical binding]; other site
395961000361	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395961000362	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395961000363	active site
395961000364	metal binding site [ion binding]; metal-binding site
395961000365	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
395961000366	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961000367	FeS/SAM binding site; other site
395961000368	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
395961000369	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
395961000370	NADP-binding site; other site
395961000371	homotetramer interface [polypeptide binding]; other site
395961000372	substrate binding site [chemical binding]; other site
395961000373	homodimer interface [polypeptide binding]; other site
395961000374	active site
395961000375	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
395961000376	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
395961000377	NADP binding site [chemical binding]; other site
395961000378	active site
395961000379	putative substrate binding site [chemical binding]; other site
395961000380	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
395961000381	AAA domain; Region: AAA_30; pfam13604
395961000382	Family description; Region: UvrD_C_2; pfam13538
395961000383	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395961000384	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
395961000385	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
395961000386	dimer interface [polypeptide binding]; other site
395961000387	decamer (pentamer of dimers) interface [polypeptide binding]; other site
395961000388	catalytic triad [active]
395961000389	MoxR-like ATPases [General function prediction only]; Region: COG0714
395961000390	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961000391	Walker A motif; other site
395961000392	ATP binding site [chemical binding]; other site
395961000393	Walker B motif; other site
395961000394	arginine finger; other site
395961000395	photosystem II 44 kDa protein; Region: psbC; CHL00035
395961000396	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
395961000397	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
395961000398	D1 interface; other site
395961000399	chlorophyll binding site; other site
395961000400	pheophytin binding site; other site
395961000401	beta carotene binding site; other site
395961000402	cytochrome b559 beta interface; other site
395961000403	quinone binding site; other site
395961000404	cytochrome b559 alpha interface; other site
395961000405	protein J interface; other site
395961000406	protein H interface; other site
395961000407	protein X interface; other site
395961000408	core light harvesting protein interface; other site
395961000409	protein L interface; other site
395961000410	CP43 interface; other site
395961000411	protein T interface; other site
395961000412	Fe binding site [ion binding]; other site
395961000413	protein M interface; other site
395961000414	Mn-stabilizing polypeptide interface; other site
395961000415	bromide binding site; other site
395961000416	cytochrome c-550 interface; other site
395961000417	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
395961000418	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
395961000419	active site
395961000420	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
395961000421	ABC1 family; Region: ABC1; cl17513
395961000422	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395961000423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395961000424	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
395961000425	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
395961000426	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961000427	Response regulator receiver domain; Region: Response_reg; pfam00072
395961000428	active site
395961000429	phosphorylation site [posttranslational modification]
395961000430	intermolecular recognition site; other site
395961000431	dimerization interface [polypeptide binding]; other site
395961000432	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
395961000433	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
395961000434	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961000435	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961000436	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
395961000437	active site
395961000438	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
395961000439	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395961000440	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
395961000441	substrate binding site [chemical binding]; other site
395961000442	putative active site [active]
395961000443	redox center [active]
395961000444	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395961000445	Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434
395961000446	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
395961000447	catalytic center binding site [active]
395961000448	ATP binding site [chemical binding]; other site
395961000449	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
395961000450	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
395961000451	dimer interface [polypeptide binding]; other site
395961000452	ADP-ribose binding site [chemical binding]; other site
395961000453	active site
395961000454	nudix motif; other site
395961000455	metal binding site [ion binding]; metal-binding site
395961000456	META domain; Region: META; pfam03724
395961000457	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
395961000458	active site
395961000459	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
395961000460	DNA photolyase; Region: DNA_photolyase; pfam00875
395961000461	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
395961000462	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
395961000463	Active_site [active]
395961000464	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
395961000465	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
395961000466	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
395961000467	Permease; Region: Permease; cl00510
395961000468	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
395961000469	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
395961000470	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
395961000471	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
395961000472	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
395961000473	ATP-sulfurylase; Region: ATPS; cd00517
395961000474	active site
395961000475	HXXH motif; other site
395961000476	flexible loop; other site
395961000477	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961000478	Ligand Binding Site [chemical binding]; other site
395961000479	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961000480	Ligand Binding Site [chemical binding]; other site
395961000481	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961000482	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961000483	active site
395961000484	ATP binding site [chemical binding]; other site
395961000485	substrate binding site [chemical binding]; other site
395961000486	activation loop (A-loop); other site
395961000487	Predicted transcriptional regulators [Transcription]; Region: COG1695
395961000488	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
395961000489	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
395961000490	Fe-S cluster binding site [ion binding]; other site
395961000491	active site
395961000492	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961000493	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
395961000494	CAAX protease self-immunity; Region: Abi; pfam02517
395961000495	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
395961000496	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
395961000497	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
395961000498	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961000499	putative active site [active]
395961000500	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
395961000501	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
395961000502	B12 binding site [chemical binding]; other site
395961000503	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961000504	FeS/SAM binding site; other site
395961000505	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011
395961000506	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
395961000507	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
395961000508	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395961000509	putative active site [active]
395961000510	putative metal binding site [ion binding]; other site
395961000511	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
395961000512	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
395961000513	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
395961000514	active site
395961000515	NTP binding site [chemical binding]; other site
395961000516	metal binding triad [ion binding]; metal-binding site
395961000517	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
395961000518	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
395961000519	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
395961000520	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
395961000521	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395961000522	NAD binding site [chemical binding]; other site
395961000523	substrate binding site [chemical binding]; other site
395961000524	active site
395961000525	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
395961000526	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
395961000527	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961000528	dimer interface [polypeptide binding]; other site
395961000529	conserved gate region; other site
395961000530	putative PBP binding loops; other site
395961000531	ABC-ATPase subunit interface; other site
395961000532	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961000533	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
395961000534	Walker A/P-loop; other site
395961000535	ATP binding site [chemical binding]; other site
395961000536	Q-loop/lid; other site
395961000537	ABC transporter signature motif; other site
395961000538	Walker B; other site
395961000539	D-loop; other site
395961000540	H-loop/switch region; other site
395961000541	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395961000542	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395961000543	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
395961000544	Predicted ATPase [General function prediction only]; Region: COG4637
395961000545	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
395961000546	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961000547	ABC transporter signature motif; other site
395961000548	Walker B; other site
395961000549	D-loop; other site
395961000550	H-loop/switch region; other site
395961000551	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
395961000552	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961000553	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961000554	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961000555	metal binding site [ion binding]; metal-binding site
395961000556	active site
395961000557	I-site; other site
395961000558	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
395961000559	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
395961000560	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395961000561	hypothetical protein; Validated; Region: PRK07581
395961000562	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
395961000563	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
395961000564	Fatty acid desaturase; Region: FA_desaturase; pfam00487
395961000565	putative di-iron ligands [ion binding]; other site
395961000566	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
395961000567	oligomeric interface; other site
395961000568	putative active site [active]
395961000569	homodimer interface [polypeptide binding]; other site
395961000570	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
395961000571	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
395961000572	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
395961000573	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
395961000574	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395961000575	Walker A motif; other site
395961000576	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
395961000577	protein-splicing catalytic site; other site
395961000578	thioester formation/cholesterol transfer; other site
395961000579	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
395961000580	protein-splicing catalytic site; other site
395961000581	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395961000582	ATP binding site [chemical binding]; other site
395961000583	Walker B motif; other site
395961000584	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
395961000585	protein-splicing catalytic site; other site
395961000586	thioester formation/cholesterol transfer; other site
395961000587	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
395961000588	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942
395961000589	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395961000590	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395961000591	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395961000592	DNA binding residues [nucleotide binding]
395961000593	dimerization interface [polypeptide binding]; other site
395961000594	GMP synthase; Reviewed; Region: guaA; PRK00074
395961000595	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
395961000596	AMP/PPi binding site [chemical binding]; other site
395961000597	candidate oxyanion hole; other site
395961000598	catalytic triad [active]
395961000599	potential glutamine specificity residues [chemical binding]; other site
395961000600	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
395961000601	ATP Binding subdomain [chemical binding]; other site
395961000602	Ligand Binding sites [chemical binding]; other site
395961000603	Dimerization subdomain; other site
395961000604	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
395961000605	cyanate hydratase; Validated; Region: PRK02866
395961000606	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
395961000607	oligomer interface [polypeptide binding]; other site
395961000608	active site
395961000609	Beta-propeller repeat; Region: SBBP; pfam06739
395961000610	PQQ-like domain; Region: PQQ_2; pfam13360
395961000611	Beta-propeller repeat; Region: SBBP; pfam06739
395961000612	Beta-propeller repeat; Region: SBBP; pfam06739
395961000613	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
395961000614	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
395961000615	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364
395961000616	L11 interface [polypeptide binding]; other site
395961000617	putative EF-Tu interaction site [polypeptide binding]; other site
395961000618	putative EF-G interaction site [polypeptide binding]; other site
395961000619	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
395961000620	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
395961000621	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
395961000622	DNA binding residues [nucleotide binding]
395961000623	dimer interface [polypeptide binding]; other site
395961000624	metal binding site [ion binding]; metal-binding site
395961000625	Cupin domain; Region: Cupin_2; cl17218
395961000626	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961000627	non-specific DNA binding site [nucleotide binding]; other site
395961000628	sequence-specific DNA binding site [nucleotide binding]; other site
395961000629	salt bridge; other site
395961000630	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395961000631	extended (e) SDRs; Region: SDR_e; cd08946
395961000632	NAD(P) binding site [chemical binding]; other site
395961000633	active site
395961000634	substrate binding site [chemical binding]; other site
395961000635	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961000636	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961000637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961000638	S-adenosylmethionine binding site [chemical binding]; other site
395961000639	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391
395961000640	P-loop motif; other site
395961000641	ATP binding site [chemical binding]; other site
395961000642	Chloramphenicol (Cm) binding site [chemical binding]; other site
395961000643	catalytic residue [active]
395961000644	tellurium resistance terB-like protein; Region: terB_like; cl11965
395961000645	metal binding site [ion binding]; metal-binding site
395961000646	Electron transfer DM13; Region: DM13; pfam10517
395961000647	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
395961000648	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
395961000649	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961000650	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961000651	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961000652	PAS fold; Region: PAS_3; pfam08447
395961000653	putative active site [active]
395961000654	heme pocket [chemical binding]; other site
395961000655	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395961000656	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961000657	putative active site [active]
395961000658	heme pocket [chemical binding]; other site
395961000659	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961000660	dimer interface [polypeptide binding]; other site
395961000661	phosphorylation site [posttranslational modification]
395961000662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961000663	ATP binding site [chemical binding]; other site
395961000664	Mg2+ binding site [ion binding]; other site
395961000665	G-X-G motif; other site
395961000666	Response regulator receiver domain; Region: Response_reg; pfam00072
395961000667	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961000668	active site
395961000669	phosphorylation site [posttranslational modification]
395961000670	intermolecular recognition site; other site
395961000671	dimerization interface [polypeptide binding]; other site
395961000672	hydrolase, alpha/beta fold family protein; Region: PLN02824
395961000673	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395961000674	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961000675	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961000676	phosphopeptide binding site; other site
395961000677	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961000678	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961000679	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961000680	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961000681	dimer interface [polypeptide binding]; other site
395961000682	phosphorylation site [posttranslational modification]
395961000683	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961000684	ATP binding site [chemical binding]; other site
395961000685	Mg2+ binding site [ion binding]; other site
395961000686	G-X-G motif; other site
395961000687	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
395961000688	ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185
395961000689	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395961000690	ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184
395961000691	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395961000692	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
395961000693	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
395961000694	HlyD family secretion protein; Region: HlyD_3; pfam13437
395961000695	DevC protein; Region: devC; TIGR01185
395961000696	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395961000697	FtsX-like permease family; Region: FtsX; pfam02687
395961000698	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
395961000699	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395961000700	Walker A/P-loop; other site
395961000701	ATP binding site [chemical binding]; other site
395961000702	Q-loop/lid; other site
395961000703	ABC transporter signature motif; other site
395961000704	Walker B; other site
395961000705	D-loop; other site
395961000706	H-loop/switch region; other site
395961000707	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961000708	Walker A/P-loop; other site
395961000709	ATP binding site [chemical binding]; other site
395961000710	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
395961000711	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
395961000712	ABC transporter signature motif; other site
395961000713	Walker B; other site
395961000714	D-loop; other site
395961000715	H-loop/switch region; other site
395961000716	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
395961000717	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961000718	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
395961000719	Transposase [DNA replication, recombination, and repair]; Region: COG5433
395961000720	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395961000721	active site
395961000722	NTP binding site [chemical binding]; other site
395961000723	metal binding triad [ion binding]; metal-binding site
395961000724	antibiotic binding site [chemical binding]; other site
395961000725	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961000726	Ligand Binding Site [chemical binding]; other site
395961000727	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
395961000728	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
395961000729	putative dimer interface [polypeptide binding]; other site
395961000730	active site pocket [active]
395961000731	putative cataytic base [active]
395961000732	2-isopropylmalate synthase; Validated; Region: PRK00915
395961000733	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
395961000734	active site
395961000735	catalytic residues [active]
395961000736	metal binding site [ion binding]; metal-binding site
395961000737	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
395961000738	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961000739	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961000740	dimer interface [polypeptide binding]; other site
395961000741	phosphorylation site [posttranslational modification]
395961000742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961000743	ATP binding site [chemical binding]; other site
395961000744	Mg2+ binding site [ion binding]; other site
395961000745	G-X-G motif; other site
395961000746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395961000747	active site
395961000748	phosphorylation site [posttranslational modification]
395961000749	intermolecular recognition site; other site
395961000750	dimerization interface [polypeptide binding]; other site
395961000751	KaiA domain; Region: KaiA; pfam07688
395961000752	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
395961000753	tetramer interface [polypeptide binding]; other site
395961000754	dimer interface [polypeptide binding]; other site
395961000755	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
395961000756	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
395961000757	Walker A motif; other site
395961000758	ATP binding site [chemical binding]; other site
395961000759	Walker B motif; other site
395961000760	recA bacterial DNA recombination protein; Region: RecA; cl17211
395961000761	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395961000762	Walker A motif; other site
395961000763	ATP binding site [chemical binding]; other site
395961000764	Walker B motif; other site
395961000765	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
395961000766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961000767	S-adenosylmethionine binding site [chemical binding]; other site
395961000768	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395961000769	dimerization interface [polypeptide binding]; other site
395961000770	putative DNA binding site [nucleotide binding]; other site
395961000771	putative Zn2+ binding site [ion binding]; other site
395961000772	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395961000773	catalytic residues [active]
395961000774	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395961000775	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
395961000776	NADP binding site [chemical binding]; other site
395961000777	substrate binding site [chemical binding]; other site
395961000778	active site
395961000779	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
395961000780	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
395961000781	FMN binding site [chemical binding]; other site
395961000782	active site
395961000783	substrate binding site [chemical binding]; other site
395961000784	catalytic residue [active]
395961000785	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
395961000786	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
395961000787	C-terminal domain interface [polypeptide binding]; other site
395961000788	GSH binding site (G-site) [chemical binding]; other site
395961000789	dimer interface [polypeptide binding]; other site
395961000790	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
395961000791	N-terminal domain interface [polypeptide binding]; other site
395961000792	putative dimer interface [polypeptide binding]; other site
395961000793	active site
395961000794	PUCC protein; Region: PUCC; pfam03209
395961000795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961000796	GTPase Era; Reviewed; Region: era; PRK00089
395961000797	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
395961000798	G1 box; other site
395961000799	GTP/Mg2+ binding site [chemical binding]; other site
395961000800	Switch I region; other site
395961000801	G2 box; other site
395961000802	Switch II region; other site
395961000803	G3 box; other site
395961000804	G4 box; other site
395961000805	G5 box; other site
395961000806	KH domain; Region: KH_2; pfam07650
395961000807	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
395961000808	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
395961000809	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
395961000810	Predicted membrane protein [Function unknown]; Region: COG1950
395961000811	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
395961000812	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
395961000813	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395961000814	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395961000815	Walker A/P-loop; other site
395961000816	ATP binding site [chemical binding]; other site
395961000817	Q-loop/lid; other site
395961000818	ABC transporter signature motif; other site
395961000819	Walker B; other site
395961000820	D-loop; other site
395961000821	H-loop/switch region; other site
395961000822	TOBE domain; Region: TOBE_2; pfam08402
395961000823	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
395961000824	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
395961000825	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961000826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961000827	active site
395961000828	phosphorylation site [posttranslational modification]
395961000829	intermolecular recognition site; other site
395961000830	dimerization interface [polypeptide binding]; other site
395961000831	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961000832	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961000833	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961000834	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961000835	putative active site [active]
395961000836	heme pocket [chemical binding]; other site
395961000837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961000838	putative active site [active]
395961000839	heme pocket [chemical binding]; other site
395961000840	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395961000841	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961000842	putative active site [active]
395961000843	heme pocket [chemical binding]; other site
395961000844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961000845	dimer interface [polypeptide binding]; other site
395961000846	phosphorylation site [posttranslational modification]
395961000847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961000848	ATP binding site [chemical binding]; other site
395961000849	Mg2+ binding site [ion binding]; other site
395961000850	G-X-G motif; other site
395961000851	Response regulator receiver domain; Region: Response_reg; pfam00072
395961000852	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961000853	active site
395961000854	phosphorylation site [posttranslational modification]
395961000855	intermolecular recognition site; other site
395961000856	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
395961000857	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
395961000858	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
395961000859	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961000860	FeS/SAM binding site; other site
395961000861	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
395961000862	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961000863	Walker A/P-loop; other site
395961000864	ATP binding site [chemical binding]; other site
395961000865	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961000866	ABC transporter signature motif; other site
395961000867	Walker B; other site
395961000868	D-loop; other site
395961000869	H-loop/switch region; other site
395961000870	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
395961000871	active site
395961000872	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
395961000873	PhoU domain; Region: PhoU; pfam01895
395961000874	PhoU domain; Region: PhoU; pfam01895
395961000875	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
395961000876	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
395961000877	GIY-YIG motif/motif A; other site
395961000878	active site
395961000879	catalytic site [active]
395961000880	putative DNA binding site [nucleotide binding]; other site
395961000881	metal binding site [ion binding]; metal-binding site
395961000882	UvrB/uvrC motif; Region: UVR; pfam02151
395961000883	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
395961000884	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
395961000885	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
395961000886	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
395961000887	dimer interface [polypeptide binding]; other site
395961000888	putative anticodon binding site; other site
395961000889	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
395961000890	motif 1; other site
395961000891	active site
395961000892	motif 2; other site
395961000893	motif 3; other site
395961000894	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
395961000895	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
395961000896	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
395961000897	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
395961000898	active site
395961000899	dimer interface [polypeptide binding]; other site
395961000900	motif 1; other site
395961000901	motif 2; other site
395961000902	motif 3; other site
395961000903	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
395961000904	anticodon binding site; other site
395961000905	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961000906	putative active site [active]
395961000907	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
395961000908	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
395961000909	dimerization interface [polypeptide binding]; other site
395961000910	active site
395961000911	metal binding site [ion binding]; metal-binding site
395961000912	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
395961000913	dsRNA binding site [nucleotide binding]; other site
395961000914	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961000915	putative active site [active]
395961000916	TRAM domain; Region: TRAM; pfam01938
395961000917	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
395961000918	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961000919	S-adenosylmethionine binding site [chemical binding]; other site
395961000920	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395961000921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961000922	active site
395961000923	phosphorylation site [posttranslational modification]
395961000924	intermolecular recognition site; other site
395961000925	dimerization interface [polypeptide binding]; other site
395961000926	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395961000927	DNA binding site [nucleotide binding]
395961000928	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395961000929	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961000930	dimer interface [polypeptide binding]; other site
395961000931	phosphorylation site [posttranslational modification]
395961000932	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961000933	ATP binding site [chemical binding]; other site
395961000934	Mg2+ binding site [ion binding]; other site
395961000935	G-X-G motif; other site
395961000936	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
395961000937	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395961000938	RNA binding surface [nucleotide binding]; other site
395961000939	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
395961000940	active site
395961000941	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
395961000942	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961000943	non-specific DNA binding site [nucleotide binding]; other site
395961000944	salt bridge; other site
395961000945	sequence-specific DNA binding site [nucleotide binding]; other site
395961000946	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
395961000947	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
395961000948	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
395961000949	putative tRNA-binding site [nucleotide binding]; other site
395961000950	B3/4 domain; Region: B3_4; pfam03483
395961000951	tRNA synthetase B5 domain; Region: B5; smart00874
395961000952	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
395961000953	dimer interface [polypeptide binding]; other site
395961000954	motif 1; other site
395961000955	motif 3; other site
395961000956	motif 2; other site
395961000957	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
395961000958	serine O-acetyltransferase; Region: cysE; TIGR01172
395961000959	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
395961000960	trimer interface [polypeptide binding]; other site
395961000961	active site
395961000962	substrate binding site [chemical binding]; other site
395961000963	CoA binding site [chemical binding]; other site
395961000964	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
395961000965	dinuclear metal binding motif [ion binding]; other site
395961000966	acyl-ACP reductase; Provisional; Region: PRK14982
395961000967	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
395961000968	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961000969	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
395961000970	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
395961000971	short chain dehydrogenase; Provisional; Region: PRK07454
395961000972	classical (c) SDRs; Region: SDR_c; cd05233
395961000973	NAD(P) binding site [chemical binding]; other site
395961000974	active site
395961000975	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
395961000976	homodecamer interface [polypeptide binding]; other site
395961000977	GTP cyclohydrolase I; Provisional; Region: PLN03044
395961000978	active site
395961000979	putative catalytic site residues [active]
395961000980	zinc binding site [ion binding]; other site
395961000981	GTP-CH-I/GFRP interaction surface; other site
395961000982	Peptidase family M48; Region: Peptidase_M48; pfam01435
395961000983	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961000984	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961000985	phosphopeptide binding site; other site
395961000986	Protease prsW family; Region: PrsW-protease; pfam13367
395961000987	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
395961000988	metal ion-dependent adhesion site (MIDAS); other site
395961000989	Protein phosphatase 2C; Region: PP2C_2; pfam13672
395961000990	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
395961000991	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
395961000992	substrate binding site [chemical binding]; other site
395961000993	activation loop (A-loop); other site
395961000994	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
395961000995	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961000996	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961000997	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961000998	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
395961000999	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961001000	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
395961001001	active site residue [active]
395961001002	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
395961001003	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395961001004	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961001005	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395961001006	NAD(P) binding site [chemical binding]; other site
395961001007	active site
395961001008	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395961001009	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
395961001010	NAD binding site [chemical binding]; other site
395961001011	homotetramer interface [polypeptide binding]; other site
395961001012	homodimer interface [polypeptide binding]; other site
395961001013	active site
395961001014	substrate binding site [chemical binding]; other site
395961001015	phosphoglucomutase; Region: PLN02307
395961001016	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
395961001017	substrate binding site [chemical binding]; other site
395961001018	dimer interface [polypeptide binding]; other site
395961001019	active site
395961001020	metal binding site [ion binding]; metal-binding site
395961001021	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
395961001022	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
395961001023	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
395961001024	Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726
395961001025	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
395961001026	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961001027	DRTGG domain; Region: DRTGG; pfam07085
395961001028	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
395961001029	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961001030	FeS/SAM binding site; other site
395961001031	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395961001032	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
395961001033	DXD motif; other site
395961001034	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961001035	Walker A motif; other site
395961001036	ATP binding site [chemical binding]; other site
395961001037	Walker B motif; other site
395961001038	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
395961001039	protein-splicing catalytic site; other site
395961001040	thioester formation/cholesterol transfer; other site
395961001041	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
395961001042	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
395961001043	protein-splicing catalytic site; other site
395961001044	DNA polymerase III subunit delta'; Validated; Region: PRK08485
395961001045	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
395961001046	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
395961001047	active site
395961001048	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
395961001049	active site
395961001050	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
395961001051	O-methyltransferase; Region: Methyltransf_2; pfam00891
395961001052	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395961001053	ribosomal protein L19; Region: rpl19; CHL00084
395961001054	Rhomboid family; Region: Rhomboid; pfam01694
395961001055	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
395961001056	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
395961001057	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
395961001058	hydrolase, alpha/beta fold family protein; Region: PLN02824
395961001059	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
395961001060	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395961001061	classical (c) SDRs; Region: SDR_c; cd05233
395961001062	NAD(P) binding site [chemical binding]; other site
395961001063	active site
395961001064	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395961001065	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395961001066	active site
395961001067	catalytic tetrad [active]
395961001068	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395961001069	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395961001070	active site
395961001071	catalytic tetrad [active]
395961001072	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395961001073	Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869
395961001074	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961001075	putative active site [active]
395961001076	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395961001077	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
395961001078	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
395961001079	active site
395961001080	dimer interface [polypeptide binding]; other site
395961001081	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
395961001082	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961001083	Coenzyme A binding pocket [chemical binding]; other site
395961001084	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961001085	non-specific DNA binding site [nucleotide binding]; other site
395961001086	salt bridge; other site
395961001087	sequence-specific DNA binding site [nucleotide binding]; other site
395961001088	Tic20-like protein; Region: Tic20; pfam09685
395961001089	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
395961001090	active site
395961001091	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395961001092	active site
395961001093	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961001094	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
395961001095	hypothetical protein; Provisional; Region: PRK02724
395961001096	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
395961001097	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
395961001098	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961001099	putative active site [active]
395961001100	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
395961001101	Acylphosphatase; Region: Acylphosphatase; pfam00708
395961001102	HypF finger; Region: zf-HYPF; pfam07503
395961001103	HypF finger; Region: zf-HYPF; pfam07503
395961001104	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
395961001105	HupF/HypC family; Region: HupF_HypC; cl00394
395961001106	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
395961001107	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
395961001108	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
395961001109	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
395961001110	dimerization interface [polypeptide binding]; other site
395961001111	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
395961001112	ATP binding site [chemical binding]; other site
395961001113	hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824
395961001114	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
395961001115	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961001116	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395961001117	dimerization interface [polypeptide binding]; other site
395961001118	putative DNA binding site [nucleotide binding]; other site
395961001119	putative Zn2+ binding site [ion binding]; other site
395961001120	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961001121	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961001122	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961001123	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961001124	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961001125	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961001126	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
395961001127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961001128	H+ Antiporter protein; Region: 2A0121; TIGR00900
395961001129	putative substrate translocation pore; other site
395961001130	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
395961001131	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
395961001132	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
395961001133	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
395961001134	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395961001135	catalytic residue [active]
395961001136	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
395961001137	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
395961001138	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
395961001139	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
395961001140	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
395961001141	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
395961001142	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
395961001143	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
395961001144	DNA binding site [nucleotide binding]
395961001145	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
395961001146	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
395961001147	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
395961001148	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
395961001149	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
395961001150	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
395961001151	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
395961001152	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
395961001153	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
395961001154	RPB1 interaction site [polypeptide binding]; other site
395961001155	RPB10 interaction site [polypeptide binding]; other site
395961001156	RPB11 interaction site [polypeptide binding]; other site
395961001157	RPB3 interaction site [polypeptide binding]; other site
395961001158	RPB12 interaction site [polypeptide binding]; other site
395961001159	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
395961001160	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
395961001161	active site
395961001162	ribosomal protein S20; Region: rps20; CHL00102
395961001163	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
395961001164	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
395961001165	catalytic residues [active]
395961001166	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
395961001167	thiamine monophosphate kinase; Provisional; Region: PRK05731
395961001168	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
395961001169	ATP binding site [chemical binding]; other site
395961001170	dimerization interface [polypeptide binding]; other site
395961001171	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
395961001172	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395961001173	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395961001174	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
395961001175	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
395961001176	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716
395961001177	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
395961001178	Uncharacterized conserved protein [Function unknown]; Region: COG2442
395961001179	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395961001180	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395961001181	Walker A/P-loop; other site
395961001182	ATP binding site [chemical binding]; other site
395961001183	Q-loop/lid; other site
395961001184	ABC transporter signature motif; other site
395961001185	Walker B; other site
395961001186	D-loop; other site
395961001187	H-loop/switch region; other site
395961001188	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395961001189	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395961001190	Walker A/P-loop; other site
395961001191	ATP binding site [chemical binding]; other site
395961001192	Q-loop/lid; other site
395961001193	ABC transporter signature motif; other site
395961001194	Walker B; other site
395961001195	D-loop; other site
395961001196	H-loop/switch region; other site
395961001197	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395961001198	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395961001199	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
395961001200	putative C-terminal domain interface [polypeptide binding]; other site
395961001201	putative GSH binding site (G-site) [chemical binding]; other site
395961001202	putative dimer interface [polypeptide binding]; other site
395961001203	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395961001204	N-terminal domain interface [polypeptide binding]; other site
395961001205	dimer interface [polypeptide binding]; other site
395961001206	substrate binding pocket (H-site) [chemical binding]; other site
395961001207	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
395961001208	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395961001209	active site
395961001210	catalytic tetrad [active]
395961001211	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
395961001212	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
395961001213	Walker A/P-loop; other site
395961001214	ATP binding site [chemical binding]; other site
395961001215	Q-loop/lid; other site
395961001216	ABC transporter signature motif; other site
395961001217	Walker B; other site
395961001218	D-loop; other site
395961001219	H-loop/switch region; other site
395961001220	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
395961001221	putative active site [active]
395961001222	putative catalytic triad [active]
395961001223	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
395961001224	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
395961001225	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
395961001226	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
395961001227	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
395961001228	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
395961001229	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
395961001230	cyanobactin biosynthesis protein, PatB/AcyB/McaB family; Region: patB_acyB_mcaB; TIGR04220
395961001231	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
395961001232	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
395961001233	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
395961001234	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
395961001235	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
395961001236	YcaO-like family; Region: YcaO; pfam02624
395961001237	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
395961001238	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
395961001239	putative FMN binding site [chemical binding]; other site
395961001240	NADPH bind site [chemical binding]; other site
395961001241	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
395961001242	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
395961001243	putative active site [active]
395961001244	putative catalytic triad [active]
395961001245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961001246	S-adenosylmethionine binding site [chemical binding]; other site
395961001247	Protein of unknown function (DUF433); Region: DUF433; pfam04255
395961001248	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
395961001249	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395961001250	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
395961001251	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
395961001252	active site
395961001253	dimer interface [polypeptide binding]; other site
395961001254	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
395961001255	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
395961001256	active site
395961001257	FMN binding site [chemical binding]; other site
395961001258	substrate binding site [chemical binding]; other site
395961001259	3Fe-4S cluster binding site [ion binding]; other site
395961001260	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
395961001261	domain interface; other site
395961001262	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
395961001263	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961001264	dimerization interface [polypeptide binding]; other site
395961001265	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961001266	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961001267	active site
395961001268	ATP binding site [chemical binding]; other site
395961001269	substrate binding site [chemical binding]; other site
395961001270	activation loop (A-loop); other site
395961001271	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
395961001272	hypothetical protein; Reviewed; Region: PRK09588
395961001273	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
395961001274	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
395961001275	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
395961001276	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
395961001277	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
395961001278	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395961001279	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961001280	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961001281	ligand binding site [chemical binding]; other site
395961001282	flexible hinge region; other site
395961001283	trehalose synthase; Region: treS_nterm; TIGR02456
395961001284	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
395961001285	active site
395961001286	homodimer interface [polypeptide binding]; other site
395961001287	catalytic site [active]
395961001288	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
395961001289	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
395961001290	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
395961001291	active site
395961001292	catalytic site [active]
395961001293	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
395961001294	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
395961001295	glycogen binding site [chemical binding]; other site
395961001296	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
395961001297	active site
395961001298	catalytic site [active]
395961001299	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
395961001300	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
395961001301	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961001302	motif II; other site
395961001303	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
395961001304	putative amphipathic alpha helix; other site
395961001305	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
395961001306	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395961001307	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395961001308	catalytic loop [active]
395961001309	iron binding site [ion binding]; other site
395961001310	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395961001311	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
395961001312	GDP-Fucose binding site [chemical binding]; other site
395961001313	HEAT repeats; Region: HEAT_2; pfam13646
395961001314	HEAT repeats; Region: HEAT_2; pfam13646
395961001315	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
395961001316	HEAT repeats; Region: HEAT_2; pfam13646
395961001317	H+ Antiporter protein; Region: 2A0121; TIGR00900
395961001318	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
395961001319	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395961001320	PYR/PP interface [polypeptide binding]; other site
395961001321	dimer interface [polypeptide binding]; other site
395961001322	TPP binding site [chemical binding]; other site
395961001323	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395961001324	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
395961001325	TPP-binding site [chemical binding]; other site
395961001326	dimer interface [polypeptide binding]; other site
395961001327	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
395961001328	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
395961001329	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395961001330	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395961001331	Soluble P-type ATPase [General function prediction only]; Region: COG4087
395961001332	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
395961001333	MoaE homodimer interface [polypeptide binding]; other site
395961001334	MoaD interaction [polypeptide binding]; other site
395961001335	active site residues [active]
395961001336	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
395961001337	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
395961001338	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
395961001339	Sm and related proteins; Region: Sm_like; cl00259
395961001340	heptamer interface [polypeptide binding]; other site
395961001341	Sm1 motif; other site
395961001342	hexamer interface [polypeptide binding]; other site
395961001343	RNA binding site [nucleotide binding]; other site
395961001344	Sm2 motif; other site
395961001345	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
395961001346	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
395961001347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961001348	binding surface
395961001349	TPR motif; other site
395961001350	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
395961001351	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
395961001352	Malic enzyme, N-terminal domain; Region: malic; pfam00390
395961001353	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
395961001354	putative NAD(P) binding site [chemical binding]; other site
395961001355	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
395961001356	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
395961001357	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395961001358	putative acyl-acceptor binding pocket; other site
395961001359	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
395961001360	FAD binding domain; Region: FAD_binding_4; pfam01565
395961001361	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
395961001362	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
395961001363	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
395961001364	metal ion-dependent adhesion site (MIDAS); other site
395961001365	Protein phosphatase 2C; Region: PP2C_2; pfam13672
395961001366	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
395961001367	substrate binding site [chemical binding]; other site
395961001368	activation loop (A-loop); other site
395961001369	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961001370	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395961001371	structural tetrad; other site
395961001372	Ion transport protein; Region: Ion_trans; pfam00520
395961001373	Ion channel; Region: Ion_trans_2; pfam07885
395961001374	Double zinc ribbon; Region: DZR; pfam12773
395961001375	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
395961001376	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
395961001377	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
395961001378	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
395961001379	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
395961001380	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961001381	ATP binding site [chemical binding]; other site
395961001382	putative Mg++ binding site [ion binding]; other site
395961001383	helicase superfamily c-terminal domain; Region: HELICc; smart00490
395961001384	ATP-binding site [chemical binding]; other site
395961001385	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
395961001386	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
395961001387	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
395961001388	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395961001389	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
395961001390	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395961001391	DNA binding residues [nucleotide binding]
395961001392	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
395961001393	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
395961001394	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
395961001395	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
395961001396	substrate binding site; other site
395961001397	dimer interface; other site
395961001398	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961001399	putative active site [active]
395961001400	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
395961001401	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395961001402	NAD binding site [chemical binding]; other site
395961001403	catalytic Zn binding site [ion binding]; other site
395961001404	structural Zn binding site [ion binding]; other site
395961001405	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
395961001406	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395961001407	NAD binding site [chemical binding]; other site
395961001408	catalytic Zn binding site [ion binding]; other site
395961001409	structural Zn binding site [ion binding]; other site
395961001410	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
395961001411	nucleoside/Zn binding site; other site
395961001412	dimer interface [polypeptide binding]; other site
395961001413	catalytic motif [active]
395961001414	Predicted integral membrane protein [Function unknown]; Region: COG5637
395961001415	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
395961001416	putative hydrophobic ligand binding site [chemical binding]; other site
395961001417	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
395961001418	intracellular protease, PfpI family; Region: PfpI; TIGR01382
395961001419	proposed catalytic triad [active]
395961001420	conserved cys residue [active]
395961001421	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
395961001422	dinuclear metal binding motif [ion binding]; other site
395961001423	short chain dehydrogenase; Provisional; Region: PRK07109
395961001424	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
395961001425	putative NAD(P) binding site [chemical binding]; other site
395961001426	active site
395961001427	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961001428	putative active site [active]
395961001429	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395961001430	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
395961001431	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
395961001432	Cache domain; Region: Cache_1; pfam02743
395961001433	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
395961001434	PAS fold; Region: PAS_4; pfam08448
395961001435	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961001436	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961001437	dimer interface [polypeptide binding]; other site
395961001438	phosphorylation site [posttranslational modification]
395961001439	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961001440	ATP binding site [chemical binding]; other site
395961001441	Mg2+ binding site [ion binding]; other site
395961001442	G-X-G motif; other site
395961001443	Response regulator receiver domain; Region: Response_reg; pfam00072
395961001444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961001445	active site
395961001446	phosphorylation site [posttranslational modification]
395961001447	intermolecular recognition site; other site
395961001448	dimerization interface [polypeptide binding]; other site
395961001449	Dihaem cytochrome c; Region: DHC; pfam09626
395961001450	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395961001451	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395961001452	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961001453	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961001454	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
395961001455	Winged helix-turn helix; Region: HTH_29; pfam13551
395961001456	Homeodomain-like domain; Region: HTH_32; pfam13565
395961001457	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
395961001458	Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450
395961001459	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
395961001460	YcfA-like protein; Region: YcfA; pfam07927
395961001461	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
395961001462	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
395961001463	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
395961001464	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
395961001465	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
395961001466	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
395961001467	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961001468	Walker A motif; other site
395961001469	ATP binding site [chemical binding]; other site
395961001470	Walker B motif; other site
395961001471	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
395961001472	RxxxH motif; other site
395961001473	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961001474	putative active site [active]
395961001475	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
395961001476	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
395961001477	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
395961001478	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961001479	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961001480	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961001481	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
395961001482	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
395961001483	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
395961001484	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
395961001485	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
395961001486	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395961001487	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395961001488	active site
395961001489	metal binding site [ion binding]; metal-binding site
395961001490	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
395961001491	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
395961001492	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
395961001493	trimer interface [polypeptide binding]; other site
395961001494	putative metal binding site [ion binding]; other site
395961001495	Photosystem II protein Y (PsbY); Region: PsbY; cl05675
395961001496	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
395961001497	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
395961001498	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
395961001499	Methyltransferase domain; Region: Methyltransf_24; pfam13578
395961001500	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
395961001501	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961001502	active site
395961001503	motif I; other site
395961001504	motif II; other site
395961001505	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
395961001506	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
395961001507	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395961001508	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395961001509	Predicted acetyltransferase [General function prediction only]; Region: COG3393
395961001510	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395961001511	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395961001512	Beta-lactamase; Region: Beta-lactamase; pfam00144
395961001513	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
395961001514	putative active site [active]
395961001515	dimerization interface [polypeptide binding]; other site
395961001516	putative tRNAtyr binding site [nucleotide binding]; other site
395961001517	Glucokinase; Region: Glucokinase; pfam02685
395961001518	glucokinase, proteobacterial type; Region: glk; TIGR00749
395961001519	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395961001520	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
395961001521	putative NAD(P) binding site [chemical binding]; other site
395961001522	catalytic Zn binding site [ion binding]; other site
395961001523	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
395961001524	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395961001525	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395961001526	ABC transporter; Region: ABC_tran_2; pfam12848
395961001527	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395961001528	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
395961001529	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
395961001530	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
395961001531	endonuclease III; Region: ENDO3c; smart00478
395961001532	minor groove reading motif; other site
395961001533	helix-hairpin-helix signature motif; other site
395961001534	substrate binding pocket [chemical binding]; other site
395961001535	active site
395961001536	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
395961001537	Acyltransferase family; Region: Acyl_transf_3; pfam01757
395961001538	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961001539	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961001540	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
395961001541	Winged helix-turn helix; Region: HTH_29; pfam13551
395961001542	Homeodomain-like domain; Region: HTH_32; pfam13565
395961001543	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
395961001544	acetylornithine aminotransferase; Provisional; Region: PRK02627
395961001545	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395961001546	inhibitor-cofactor binding pocket; inhibition site
395961001547	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961001548	catalytic residue [active]
395961001549	NurA nuclease; Region: NurA; smart00933
395961001550	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
395961001551	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
395961001552	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
395961001553	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
395961001554	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
395961001555	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
395961001556	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
395961001557	putative active site [active]
395961001558	putative metal binding residues [ion binding]; other site
395961001559	signature motif; other site
395961001560	putative dimer interface [polypeptide binding]; other site
395961001561	putative phosphate binding site [ion binding]; other site
395961001562	ribosomal protein L21; Region: rpl21; CHL00075
395961001563	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
395961001564	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
395961001565	Uncharacterized conserved protein [Function unknown]; Region: COG0062
395961001566	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
395961001567	putative substrate binding site [chemical binding]; other site
395961001568	putative ATP binding site [chemical binding]; other site
395961001569	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
395961001570	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
395961001571	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395961001572	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
395961001573	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961001574	motif II; other site
395961001575	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
395961001576	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
395961001577	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
395961001578	putative RNA binding site [nucleotide binding]; other site
395961001579	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961001580	S-adenosylmethionine binding site [chemical binding]; other site
395961001581	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
395961001582	YcfA-like protein; Region: YcfA; pfam07927
395961001583	enoyl-CoA hydratase; Provisional; Region: PRK05995
395961001584	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
395961001585	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
395961001586	oligomeric interface; other site
395961001587	putative active site [active]
395961001588	homodimer interface [polypeptide binding]; other site
395961001589	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
395961001590	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
395961001591	motif 1; other site
395961001592	active site
395961001593	motif 2; other site
395961001594	motif 3; other site
395961001595	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
395961001596	DHHA1 domain; Region: DHHA1; pfam02272
395961001597	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
395961001598	glutaminase; Provisional; Region: PRK00971
395961001599	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
395961001600	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
395961001601	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961001602	putative active site [active]
395961001603	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395961001604	PBP superfamily domain; Region: PBP_like_2; cl17296
395961001605	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
395961001606	Low molecular weight phosphatase family; Region: LMWPc; cl00105
395961001607	active site
395961001608	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
395961001609	Low molecular weight phosphatase family; Region: LMWPc; cd00115
395961001610	active site
395961001611	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
395961001612	arsenical-resistance protein; Region: acr3; TIGR00832
395961001613	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961001614	putative substrate translocation pore; other site
395961001615	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395961001616	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
395961001617	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
395961001618	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
395961001619	PBP superfamily domain; Region: PBP_like_2; cl17296
395961001620	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395961001621	dimerization interface [polypeptide binding]; other site
395961001622	putative DNA binding site [nucleotide binding]; other site
395961001623	putative Zn2+ binding site [ion binding]; other site
395961001624	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395961001625	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961001626	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961001627	Walker A/P-loop; other site
395961001628	ATP binding site [chemical binding]; other site
395961001629	Q-loop/lid; other site
395961001630	ABC transporter signature motif; other site
395961001631	Walker B; other site
395961001632	D-loop; other site
395961001633	H-loop/switch region; other site
395961001634	S-layer homology domain; Region: SLH; pfam00395
395961001635	S-layer homology domain; Region: SLH; pfam00395
395961001636	S-layer homology domain; Region: SLH; pfam00395
395961001637	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
395961001638	conserved hypothetical protein; Region: TIGR03492
395961001639	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
395961001640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
395961001641	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
395961001642	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
395961001643	nucleotide binding pocket [chemical binding]; other site
395961001644	K-X-D-G motif; other site
395961001645	catalytic site [active]
395961001646	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
395961001647	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
395961001648	Helix-hairpin-helix motif; Region: HHH; pfam00633
395961001649	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
395961001650	Dimer interface [polypeptide binding]; other site
395961001651	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
395961001652	V4R domain; Region: V4R; pfam02830
395961001653	Phycobilisome protein; Region: Phycobilisome; cl08227
395961001654	elongation factor P; Validated; Region: PRK00529
395961001655	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
395961001656	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
395961001657	RNA binding site [nucleotide binding]; other site
395961001658	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
395961001659	RNA binding site [nucleotide binding]; other site
395961001660	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
395961001661	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395961001662	carboxyltransferase (CT) interaction site; other site
395961001663	biotinylation site [posttranslational modification]; other site
395961001664	alanine racemase; Reviewed; Region: alr; PRK00053
395961001665	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
395961001666	active site
395961001667	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395961001668	dimer interface [polypeptide binding]; other site
395961001669	substrate binding site [chemical binding]; other site
395961001670	catalytic residues [active]
395961001671	16S rRNA methyltransferase B; Provisional; Region: PRK14901
395961001672	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
395961001673	putative RNA binding site [nucleotide binding]; other site
395961001674	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961001675	S-adenosylmethionine binding site [chemical binding]; other site
395961001676	Protein of unknown function (DUF2541); Region: DUF2541; cl08090
395961001677	Protein of unknown function (DUF2541); Region: DUF2541; cl08090
395961001678	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
395961001679	amidase catalytic site [active]
395961001680	Zn binding residues [ion binding]; other site
395961001681	substrate binding site [chemical binding]; other site
395961001682	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
395961001683	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
395961001684	active site
395961001685	ATP binding site [chemical binding]; other site
395961001686	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
395961001687	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
395961001688	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
395961001689	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
395961001690	homotrimer interface [polypeptide binding]; other site
395961001691	Walker A motif; other site
395961001692	GTP binding site [chemical binding]; other site
395961001693	Walker B motif; other site
395961001694	adaptive-response sensory kinase; Validated; Region: PRK09303
395961001695	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
395961001696	tetramer interface [polypeptide binding]; other site
395961001697	dimer interface [polypeptide binding]; other site
395961001698	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961001699	dimer interface [polypeptide binding]; other site
395961001700	phosphorylation site [posttranslational modification]
395961001701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961001702	ATP binding site [chemical binding]; other site
395961001703	Mg2+ binding site [ion binding]; other site
395961001704	G-X-G motif; other site
395961001705	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
395961001706	O-methyltransferase; Region: Methyltransf_2; pfam00891
395961001707	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395961001708	Beta-lactamase; Region: Beta-lactamase; pfam00144
395961001709	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
395961001710	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
395961001711	ATP binding site [chemical binding]; other site
395961001712	substrate interface [chemical binding]; other site
395961001713	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
395961001714	Recombinase; Region: Recombinase; pfam07508
395961001715	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
395961001716	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
395961001717	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
395961001718	active site
395961001719	catalytic residues [active]
395961001720	DNA binding site [nucleotide binding]
395961001721	Int/Topo IB signature motif; other site
395961001722	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
395961001723	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
395961001724	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
395961001725	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
395961001726	ATP binding site [chemical binding]; other site
395961001727	Mg2+ binding site [ion binding]; other site
395961001728	G-X-G motif; other site
395961001729	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
395961001730	anti sigma factor interaction site; other site
395961001731	regulatory phosphorylation site [posttranslational modification]; other site
395961001732	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
395961001733	anti sigma factor interaction site; other site
395961001734	regulatory phosphorylation site [posttranslational modification]; other site
395961001735	WD40 repeats; Region: WD40; smart00320
395961001736	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961001737	structural tetrad; other site
395961001738	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395961001739	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961001740	structural tetrad; other site
395961001741	WD40 repeats; Region: WD40; smart00320
395961001742	WD40 repeats; Region: WD40; smart00320
395961001743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961001744	S-adenosylmethionine binding site [chemical binding]; other site
395961001745	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
395961001746	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
395961001747	elongation factor Tu; Region: tufA; CHL00071
395961001748	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
395961001749	G1 box; other site
395961001750	GEF interaction site [polypeptide binding]; other site
395961001751	GTP/Mg2+ binding site [chemical binding]; other site
395961001752	Switch I region; other site
395961001753	G2 box; other site
395961001754	G3 box; other site
395961001755	Switch II region; other site
395961001756	G4 box; other site
395961001757	G5 box; other site
395961001758	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
395961001759	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
395961001760	Antibiotic Binding Site [chemical binding]; other site
395961001761	elongation factor G; Reviewed; Region: PRK00007
395961001762	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
395961001763	G1 box; other site
395961001764	putative GEF interaction site [polypeptide binding]; other site
395961001765	GTP/Mg2+ binding site [chemical binding]; other site
395961001766	Switch I region; other site
395961001767	G2 box; other site
395961001768	G3 box; other site
395961001769	Switch II region; other site
395961001770	G4 box; other site
395961001771	G5 box; other site
395961001772	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
395961001773	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
395961001774	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
395961001775	30S ribosomal protein S7; Validated; Region: PRK05302
395961001776	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
395961001777	S17 interaction site [polypeptide binding]; other site
395961001778	S8 interaction site; other site
395961001779	16S rRNA interaction site [nucleotide binding]; other site
395961001780	streptomycin interaction site [chemical binding]; other site
395961001781	23S rRNA interaction site [nucleotide binding]; other site
395961001782	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
395961001783	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
395961001784	Stage II sporulation protein; Region: SpoIID; pfam08486
395961001785	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
395961001786	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
395961001787	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395961001788	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961001789	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961001790	active site
395961001791	ATP binding site [chemical binding]; other site
395961001792	substrate binding site [chemical binding]; other site
395961001793	activation loop (A-loop); other site
395961001794	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961001795	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961001796	phosphopeptide binding site; other site
395961001797	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
395961001798	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395961001799	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348
395961001800	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
395961001801	putative ligand binding site [chemical binding]; other site
395961001802	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
395961001803	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
395961001804	putative valine binding site [chemical binding]; other site
395961001805	dimer interface [polypeptide binding]; other site
395961001806	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
395961001807	Predicted membrane protein [Function unknown]; Region: COG3463
395961001808	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
395961001809	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
395961001810	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395961001811	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395961001812	catalytic residue [active]
395961001813	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
395961001814	AMIN domain; Region: AMIN; pfam11741
395961001815	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
395961001816	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
395961001817	active site
395961001818	metal binding site [ion binding]; metal-binding site
395961001819	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961001820	NADH(P)-binding; Region: NAD_binding_10; pfam13460
395961001821	NAD(P) binding site [chemical binding]; other site
395961001822	active site
395961001823	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
395961001824	UbiA prenyltransferase family; Region: UbiA; pfam01040
395961001825	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
395961001826	Phosphoribosyl transferase domain; Region: Pribosyltran; pfam00156
395961001827	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
395961001828	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395961001829	HSP70 interaction site [polypeptide binding]; other site
395961001830	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
395961001831	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961001832	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961001833	metal binding site [ion binding]; metal-binding site
395961001834	active site
395961001835	I-site; other site
395961001836	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
395961001837	ArsC family; Region: ArsC; pfam03960
395961001838	catalytic residue [active]
395961001839	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
395961001840	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
395961001841	B12 binding site [chemical binding]; other site
395961001842	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961001843	FeS/SAM binding site; other site
395961001844	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
395961001845	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
395961001846	active site
395961001847	catalytic residues [active]
395961001848	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
395961001849	active site
395961001850	photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049
395961001851	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
395961001852	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961001853	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961001854	ligand binding site [chemical binding]; other site
395961001855	flexible hinge region; other site
395961001856	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
395961001857	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395961001858	Walker A motif; other site
395961001859	ATP binding site [chemical binding]; other site
395961001860	Walker B motif; other site
395961001861	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
395961001862	4Fe-4S binding domain; Region: Fer4_5; pfam12801
395961001863	4Fe-4S binding domain; Region: Fer4_5; pfam12801
395961001864	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
395961001865	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
395961001866	active site
395961001867	dimer interface [polypeptide binding]; other site
395961001868	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
395961001869	dimer interface [polypeptide binding]; other site
395961001870	active site
395961001871	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961001872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961001873	active site
395961001874	phosphorylation site [posttranslational modification]
395961001875	intermolecular recognition site; other site
395961001876	dimerization interface [polypeptide binding]; other site
395961001877	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
395961001878	dimer interface [polypeptide binding]; other site
395961001879	phosphorylation site [posttranslational modification]
395961001880	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961001881	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961001882	dimer interface [polypeptide binding]; other site
395961001883	phosphorylation site [posttranslational modification]
395961001884	Response regulator receiver domain; Region: Response_reg; pfam00072
395961001885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961001886	active site
395961001887	phosphorylation site [posttranslational modification]
395961001888	intermolecular recognition site; other site
395961001889	dimerization interface [polypeptide binding]; other site
395961001890	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
395961001891	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961001892	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395961001893	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395961001894	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395961001895	protein binding site [polypeptide binding]; other site
395961001896	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395961001897	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395961001898	M28 Zn-Peptidases; Region: M28_like_1; cd05640
395961001899	Peptidase family M28; Region: Peptidase_M28; pfam04389
395961001900	metal binding site [ion binding]; metal-binding site
395961001901	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961001902	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
395961001903	ligand binding site [chemical binding]; other site
395961001904	flexible hinge region; other site
395961001905	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395961001906	putative switch regulator; other site
395961001907	non-specific DNA interactions [nucleotide binding]; other site
395961001908	DNA binding site [nucleotide binding]
395961001909	sequence specific DNA binding site [nucleotide binding]; other site
395961001910	putative cAMP binding site [chemical binding]; other site
395961001911	S-formylglutathione hydrolase; Region: PLN02442
395961001912	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
395961001913	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
395961001914	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395961001915	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
395961001916	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
395961001917	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
395961001918	classical (c) SDRs; Region: SDR_c; cd05233
395961001919	NAD(P) binding site [chemical binding]; other site
395961001920	active site
395961001921	Dynamin family; Region: Dynamin_N; pfam00350
395961001922	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
395961001923	G1 box; other site
395961001924	GTP/Mg2+ binding site [chemical binding]; other site
395961001925	Switch I region; other site
395961001926	G2 box; other site
395961001927	Switch II region; other site
395961001928	G3 box; other site
395961001929	G4 box; other site
395961001930	G5 box; other site
395961001931	Domain of unknown function (DUF697); Region: DUF697; pfam05128
395961001932	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
395961001933	G4 box; other site
395961001934	G5 box; other site
395961001935	Domain of unknown function (DUF697); Region: DUF697; pfam05128
395961001936	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395961001937	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395961001938	active site
395961001939	catalytic tetrad [active]
395961001940	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961001941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961001942	S-adenosylmethionine binding site [chemical binding]; other site
395961001943	TPR repeat; Region: TPR_11; pfam13414
395961001944	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961001945	binding surface
395961001946	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
395961001947	AAA domain; Region: AAA_33; pfam13671
395961001948	ATP-binding site [chemical binding]; other site
395961001949	Gluconate-6-phosphate binding site [chemical binding]; other site
395961001950	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
395961001951	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
395961001952	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
395961001953	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
395961001954	active site
395961001955	Zn binding site [ion binding]; other site
395961001956	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
395961001957	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
395961001958	ATP binding site [chemical binding]; other site
395961001959	Mg2+ binding site [ion binding]; other site
395961001960	G-X-G motif; other site
395961001961	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
395961001962	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
395961001963	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
395961001964	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
395961001965	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395961001966	purine nucleoside phosphorylase; Provisional; Region: PRK08202
395961001967	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
395961001968	Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407
395961001969	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
395961001970	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
395961001971	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395961001972	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395961001973	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395961001974	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961001975	binding surface
395961001976	TPR motif; other site
395961001977	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961001978	binding surface
395961001979	TPR motif; other site
395961001980	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961001981	binding surface
395961001982	TPR motif; other site
395961001983	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
395961001984	active site
395961001985	DNA binding site [nucleotide binding]
395961001986	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
395961001987	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
395961001988	Beta-Casp domain; Region: Beta-Casp; cl12567
395961001989	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961001990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961001991	active site
395961001992	phosphorylation site [posttranslational modification]
395961001993	intermolecular recognition site; other site
395961001994	dimerization interface [polypeptide binding]; other site
395961001995	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961001996	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395961001997	putative active site [active]
395961001998	heme pocket [chemical binding]; other site
395961001999	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961002000	dimer interface [polypeptide binding]; other site
395961002001	phosphorylation site [posttranslational modification]
395961002002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961002003	ATP binding site [chemical binding]; other site
395961002004	Mg2+ binding site [ion binding]; other site
395961002005	G-X-G motif; other site
395961002006	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961002007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002008	active site
395961002009	phosphorylation site [posttranslational modification]
395961002010	intermolecular recognition site; other site
395961002011	dimerization interface [polypeptide binding]; other site
395961002012	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961002013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002014	active site
395961002015	phosphorylation site [posttranslational modification]
395961002016	intermolecular recognition site; other site
395961002017	dimerization interface [polypeptide binding]; other site
395961002018	Response regulator receiver domain; Region: Response_reg; pfam00072
395961002019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002020	active site
395961002021	phosphorylation site [posttranslational modification]
395961002022	intermolecular recognition site; other site
395961002023	dimerization interface [polypeptide binding]; other site
395961002024	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961002025	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961002026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961002027	dimer interface [polypeptide binding]; other site
395961002028	phosphorylation site [posttranslational modification]
395961002029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961002030	ATP binding site [chemical binding]; other site
395961002031	Mg2+ binding site [ion binding]; other site
395961002032	G-X-G motif; other site
395961002033	Protein kinase domain; Region: Pkinase; pfam00069
395961002034	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961002035	active site
395961002036	ATP binding site [chemical binding]; other site
395961002037	substrate binding site [chemical binding]; other site
395961002038	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
395961002039	substrate binding site [chemical binding]; other site
395961002040	activation loop (A-loop); other site
395961002041	activation loop (A-loop); other site
395961002042	AAA ATPase domain; Region: AAA_16; pfam13191
395961002043	Predicted ATPase [General function prediction only]; Region: COG3899
395961002044	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961002045	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961002046	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961002047	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961002048	dimer interface [polypeptide binding]; other site
395961002049	phosphorylation site [posttranslational modification]
395961002050	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961002051	ATP binding site [chemical binding]; other site
395961002052	Mg2+ binding site [ion binding]; other site
395961002053	G-X-G motif; other site
395961002054	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961002055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002056	active site
395961002057	phosphorylation site [posttranslational modification]
395961002058	intermolecular recognition site; other site
395961002059	dimerization interface [polypeptide binding]; other site
395961002060	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
395961002061	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
395961002062	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
395961002063	YcfA-like protein; Region: YcfA; pfam07927
395961002064	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
395961002065	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
395961002066	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
395961002067	metal ion-dependent adhesion site (MIDAS); other site
395961002068	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961002069	putative active site [active]
395961002070	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961002071	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961002072	active site
395961002073	ATP binding site [chemical binding]; other site
395961002074	substrate binding site [chemical binding]; other site
395961002075	activation loop (A-loop); other site
395961002076	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
395961002077	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
395961002078	TPP-binding site [chemical binding]; other site
395961002079	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
395961002080	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
395961002081	active site
395961002082	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
395961002083	FOG: CBS domain [General function prediction only]; Region: COG0517
395961002084	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
395961002085	CP12 domain; Region: CP12; cl14670
395961002086	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
395961002087	TrkA-N domain; Region: TrkA_N; pfam02254
395961002088	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395961002089	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395961002090	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961002091	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961002092	metal binding site [ion binding]; metal-binding site
395961002093	active site
395961002094	I-site; other site
395961002095	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
395961002096	anti sigma factor interaction site; other site
395961002097	regulatory phosphorylation site [posttranslational modification]; other site
395961002098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
395961002099	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395961002100	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
395961002101	putative ligand binding site [chemical binding]; other site
395961002102	PAS domain S-box; Region: sensory_box; TIGR00229
395961002103	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961002104	putative active site [active]
395961002105	heme pocket [chemical binding]; other site
395961002106	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
395961002107	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
395961002108	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
395961002109	Domain of unknown function DUF39; Region: DUF39; pfam01837
395961002110	Uncharacterized conserved protein [Function unknown]; Region: COG5464
395961002111	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
395961002112	dimerization interface [polypeptide binding]; other site
395961002113	active site
395961002114	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
395961002115	Right handed beta helix region; Region: Beta_helix; pfam13229
395961002116	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
395961002117	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
395961002118	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
395961002119	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
395961002120	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
395961002121	intersubunit interface [polypeptide binding]; other site
395961002122	S-layer homology domain; Region: SLH; pfam00395
395961002123	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
395961002124	RDD family; Region: RDD; pfam06271
395961002125	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
395961002126	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
395961002127	quinone interaction residues [chemical binding]; other site
395961002128	active site
395961002129	catalytic residues [active]
395961002130	FMN binding site [chemical binding]; other site
395961002131	substrate binding site [chemical binding]; other site
395961002132	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
395961002133	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961002134	FeS/SAM binding site; other site
395961002135	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
395961002136	DNA methylase; Region: N6_N4_Mtase; cl17433
395961002137	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
395961002138	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
395961002139	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961002140	FeS/SAM binding site; other site
395961002141	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
395961002142	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
395961002143	cobalamin binding residues [chemical binding]; other site
395961002144	putative BtuC binding residues; other site
395961002145	dimer interface [polypeptide binding]; other site
395961002146	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
395961002147	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
395961002148	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961002149	FeS/SAM binding site; other site
395961002150	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
395961002151	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
395961002152	N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional; Region: PRK04338
395961002153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961002154	S-adenosylmethionine binding site [chemical binding]; other site
395961002155	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
395961002156	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395961002157	Protein of unknown function (DUF751); Region: DUF751; pfam05421
395961002158	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
395961002159	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
395961002160	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
395961002161	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961002162	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961002163	ligand binding site [chemical binding]; other site
395961002164	flexible hinge region; other site
395961002165	tellurium resistance terB-like protein; Region: terB_like; cd07177
395961002166	metal binding site [ion binding]; metal-binding site
395961002167	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
395961002168	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961002169	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961002170	ligand binding site [chemical binding]; other site
395961002171	flexible hinge region; other site
395961002172	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
395961002173	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
395961002174	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
395961002175	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
395961002176	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395961002177	Cl- selectivity filter; other site
395961002178	Cl- binding residues [ion binding]; other site
395961002179	pore gating glutamate residue; other site
395961002180	dimer interface [polypeptide binding]; other site
395961002181	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593
395961002182	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
395961002183	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
395961002184	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961002185	motif II; other site
395961002186	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961002187	DNA polymerase I; Provisional; Region: PRK05755
395961002188	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
395961002189	active site
395961002190	metal binding site 1 [ion binding]; metal-binding site
395961002191	putative 5' ssDNA interaction site; other site
395961002192	metal binding site 3; metal-binding site
395961002193	metal binding site 2 [ion binding]; metal-binding site
395961002194	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
395961002195	putative DNA binding site [nucleotide binding]; other site
395961002196	putative metal binding site [ion binding]; other site
395961002197	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
395961002198	active site
395961002199	catalytic site [active]
395961002200	substrate binding site [chemical binding]; other site
395961002201	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
395961002202	active site
395961002203	DNA binding site [nucleotide binding]
395961002204	catalytic site [active]
395961002205	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395961002206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002207	active site
395961002208	phosphorylation site [posttranslational modification]
395961002209	intermolecular recognition site; other site
395961002210	dimerization interface [polypeptide binding]; other site
395961002211	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395961002212	DNA binding site [nucleotide binding]
395961002213	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
395961002214	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
395961002215	Walker A/P-loop; other site
395961002216	ATP binding site [chemical binding]; other site
395961002217	Q-loop/lid; other site
395961002218	ABC transporter signature motif; other site
395961002219	Walker B; other site
395961002220	D-loop; other site
395961002221	H-loop/switch region; other site
395961002222	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
395961002223	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961002224	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961002225	phosphopeptide binding site; other site
395961002226	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395961002227	cyclase homology domain; Region: CHD; cd07302
395961002228	nucleotidyl binding site; other site
395961002229	metal binding site [ion binding]; metal-binding site
395961002230	dimer interface [polypeptide binding]; other site
395961002231	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
395961002232	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
395961002233	active site
395961002234	HIGH motif; other site
395961002235	dimer interface [polypeptide binding]; other site
395961002236	KMSKS motif; other site
395961002237	Transglycosylase; Region: Transgly; pfam00912
395961002238	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
395961002239	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395961002240	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
395961002241	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395961002242	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395961002243	catalytic loop [active]
395961002244	iron binding site [ion binding]; other site
395961002245	photosystem II 47 kDa protein; Region: psbB; CHL00062
395961002246	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
395961002247	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961002248	putative active site [active]
395961002249	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
395961002250	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
395961002251	tetramer interface [polypeptide binding]; other site
395961002252	active site
395961002253	Mg2+/Mn2+ binding site [ion binding]; other site
395961002254	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
395961002255	catalytic triad [active]
395961002256	hypothetical protein; Validated; Region: PRK00029
395961002257	Uncharacterized conserved protein [Function unknown]; Region: COG0397
395961002258	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395961002259	D-xylulose kinase; Region: XylB; TIGR01312
395961002260	nucleotide binding site [chemical binding]; other site
395961002261	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
395961002262	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
395961002263	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
395961002264	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961002265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961002266	Homeodomain-like domain; Region: HTH_23; pfam13384
395961002267	Winged helix-turn helix; Region: HTH_29; pfam13551
395961002268	Homeodomain-like domain; Region: HTH_32; pfam13565
395961002269	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333
395961002270	photosystem I reaction center subunit X-like protein; Reviewed; Region: PRK13216
395961002271	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
395961002272	HPP family; Region: HPP; pfam04982
395961002273	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961002274	TPR motif; other site
395961002275	binding surface
395961002276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961002277	binding surface
395961002278	TPR motif; other site
395961002279	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961002280	putative active site [active]
395961002281	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395961002282	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
395961002283	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395961002284	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
395961002285	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961002286	FeS/SAM binding site; other site
395961002287	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
395961002288	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395961002289	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395961002290	catalytic loop [active]
395961002291	iron binding site [ion binding]; other site
395961002292	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
395961002293	MltA specific insert domain; Region: MltA; pfam03562
395961002294	3D domain; Region: 3D; pfam06725
395961002295	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
395961002296	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
395961002297	TrkA-N domain; Region: TrkA_N; pfam02254
395961002298	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
395961002299	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961002300	putative active site [active]
395961002301	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
395961002302	Ycf46; Provisional; Region: ycf46; CHL00195
395961002303	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961002304	Walker A motif; other site
395961002305	ATP binding site [chemical binding]; other site
395961002306	Walker B motif; other site
395961002307	arginine finger; other site
395961002308	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961002309	S-adenosylmethionine binding site [chemical binding]; other site
395961002310	Asparaginase [Amino acid transport and metabolism]; Region: COG1446
395961002311	active site
395961002312	dimer interface [polypeptide binding]; other site
395961002313	catalytic nucleophile [active]
395961002314	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
395961002315	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
395961002316	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395961002317	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395961002318	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
395961002319	FAD binding domain; Region: FAD_binding_4; pfam01565
395961002320	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
395961002321	hypothetical protein; Validated; Region: PRK00153
395961002322	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395961002323	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395961002324	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395961002325	Exoribonuclease R [Transcription]; Region: VacB; COG0557
395961002326	RNB domain; Region: RNB; pfam00773
395961002327	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
395961002328	ribosomal protein L33; Region: rpl33; CHL00104
395961002329	RDD family; Region: RDD; pfam06271
395961002330	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
395961002331	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
395961002332	dimer interface [polypeptide binding]; other site
395961002333	putative functional site; other site
395961002334	putative MPT binding site; other site
395961002335	heat shock protein HtpX; Provisional; Region: PRK03982
395961002336	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
395961002337	PHP domain; Region: PHP; pfam02811
395961002338	active site
395961002339	Repair protein; Region: Repair_PSII; pfam04536
395961002340	reductive dehalogenase; Region: RDH; TIGR02486
395961002341	4Fe-4S binding domain; Region: Fer4; pfam00037
395961002342	SCP-2 sterol transfer family; Region: SCP2; pfam02036
395961002343	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395961002344	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
395961002345	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
395961002346	active site
395961002347	catalytic residues [active]
395961002348	metal binding site [ion binding]; metal-binding site
395961002349	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
395961002350	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
395961002351	putative active site [active]
395961002352	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395961002353	active site
395961002354	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
395961002355	active site
395961002356	putative DNA-binding cleft [nucleotide binding]; other site
395961002357	dimer interface [polypeptide binding]; other site
395961002358	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
395961002359	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
395961002360	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961002361	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961002362	phosphopeptide binding site; other site
395961002363	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961002364	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
395961002365	putative ADP-binding pocket [chemical binding]; other site
395961002366	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
395961002367	C-terminal peptidase (prc); Region: prc; TIGR00225
395961002368	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
395961002369	protein binding site [polypeptide binding]; other site
395961002370	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
395961002371	Catalytic dyad [active]
395961002372	PRC-barrel domain; Region: PRC; pfam05239
395961002373	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
395961002374	calcium/proton exchanger (cax); Region: cax; TIGR00378
395961002375	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
395961002376	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
395961002377	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
395961002378	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
395961002379	dimer interface [polypeptide binding]; other site
395961002380	decamer (pentamer of dimers) interface [polypeptide binding]; other site
395961002381	catalytic triad [active]
395961002382	peroxidatic and resolving cysteines [active]
395961002383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
395961002384	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961002385	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961002386	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961002387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961002388	S-adenosylmethionine binding site [chemical binding]; other site
395961002389	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395961002390	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
395961002391	TPR repeat; Region: TPR_11; pfam13414
395961002392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395961002393	binding surface
395961002394	TPR motif; other site
395961002395	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
395961002396	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
395961002397	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
395961002398	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
395961002399	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
395961002400	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961002401	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
395961002402	putative metal binding site; other site
395961002403	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961002404	TPR motif; other site
395961002405	binding surface
395961002406	Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938
395961002407	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
395961002408	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
395961002409	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
395961002410	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
395961002411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961002412	dimer interface [polypeptide binding]; other site
395961002413	conserved gate region; other site
395961002414	putative PBP binding loops; other site
395961002415	ABC-ATPase subunit interface; other site
395961002416	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
395961002417	homodimer interface [polypeptide binding]; other site
395961002418	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961002419	catalytic residue [active]
395961002420	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
395961002421	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
395961002422	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
395961002423	Predicted membrane protein [Function unknown]; Region: COG2323
395961002424	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
395961002425	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
395961002426	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961002427	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
395961002428	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
395961002429	putative active site [active]
395961002430	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
395961002431	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
395961002432	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
395961002433	putative catalytic residue [active]
395961002434	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
395961002435	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
395961002436	Phosphoglycerate kinase; Region: PGK; pfam00162
395961002437	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
395961002438	substrate binding site [chemical binding]; other site
395961002439	hinge regions; other site
395961002440	ADP binding site [chemical binding]; other site
395961002441	catalytic site [active]
395961002442	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961002443	Ligand Binding Site [chemical binding]; other site
395961002444	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961002445	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961002446	active site
395961002447	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
395961002448	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
395961002449	dimer interface [polypeptide binding]; other site
395961002450	anticodon binding site; other site
395961002451	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
395961002452	homodimer interface [polypeptide binding]; other site
395961002453	motif 1; other site
395961002454	active site
395961002455	motif 2; other site
395961002456	GAD domain; Region: GAD; pfam02938
395961002457	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395961002458	active site
395961002459	motif 3; other site
395961002460	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
395961002461	putative dimer interface [polypeptide binding]; other site
395961002462	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395961002463	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961002464	putative active site [active]
395961002465	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395961002466	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961002467	H+ Antiporter protein; Region: 2A0121; TIGR00900
395961002468	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961002469	putative substrate translocation pore; other site
395961002470	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
395961002471	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
395961002472	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961002473	Walker A motif; other site
395961002474	ATP binding site [chemical binding]; other site
395961002475	Divergent PAP2 family; Region: DUF212; pfam02681
395961002476	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
395961002477	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
395961002478	substrate binding pocket [chemical binding]; other site
395961002479	chain length determination region; other site
395961002480	substrate-Mg2+ binding site; other site
395961002481	catalytic residues [active]
395961002482	aspartate-rich region 1; other site
395961002483	active site lid residues [active]
395961002484	aspartate-rich region 2; other site
395961002485	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
395961002486	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
395961002487	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
395961002488	homodimer interface [polypeptide binding]; other site
395961002489	NADP binding site [chemical binding]; other site
395961002490	substrate binding site [chemical binding]; other site
395961002491	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
395961002492	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395961002493	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
395961002494	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
395961002495	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395961002496	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
395961002497	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395961002498	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
395961002499	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395961002500	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
395961002501	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
395961002502	intersubunit interface [polypeptide binding]; other site
395961002503	active site
395961002504	catalytic residue [active]
395961002505	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
395961002506	Recombination protein O N terminal; Region: RecO_N; pfam11967
395961002507	Recombination protein O C terminal; Region: RecO_C; pfam02565
395961002508	H+ Antiporter protein; Region: 2A0121; TIGR00900
395961002509	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961002510	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961002511	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395961002512	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002513	active site
395961002514	phosphorylation site [posttranslational modification]
395961002515	intermolecular recognition site; other site
395961002516	dimerization interface [polypeptide binding]; other site
395961002517	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395961002518	DNA binding residues [nucleotide binding]
395961002519	dimerization interface [polypeptide binding]; other site
395961002520	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
395961002521	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
395961002522	metal binding site [ion binding]; metal-binding site
395961002523	dimer interface [polypeptide binding]; other site
395961002524	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
395961002525	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
395961002526	tetramer interface [polypeptide binding]; other site
395961002527	TPP-binding site [chemical binding]; other site
395961002528	heterodimer interface [polypeptide binding]; other site
395961002529	phosphorylation loop region [posttranslational modification]
395961002530	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395961002531	HSP70 interaction site [polypeptide binding]; other site
395961002532	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
395961002533	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
395961002534	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
395961002535	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
395961002536	trimer interface [polypeptide binding]; other site
395961002537	active site
395961002538	UDP-GlcNAc binding site [chemical binding]; other site
395961002539	lipid binding site [chemical binding]; lipid-binding site
395961002540	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
395961002541	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
395961002542	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
395961002543	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
395961002544	trimer interface [polypeptide binding]; other site
395961002545	active site
395961002546	UDP-GlcNAc binding site [chemical binding]; other site
395961002547	lipid binding site [chemical binding]; lipid-binding site
395961002548	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461
395961002549	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
395961002550	active site
395961002551	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395961002552	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
395961002553	metal-binding site [ion binding]
395961002554	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395961002555	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961002556	motif II; other site
395961002557	thymidylate kinase; Validated; Region: tmk; PRK00698
395961002558	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
395961002559	TMP-binding site; other site
395961002560	ATP-binding site [chemical binding]; other site
395961002561	DNA polymerase III subunit delta'; Validated; Region: PRK07399
395961002562	DNA polymerase III subunit delta'; Validated; Region: PRK08485
395961002563	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395961002564	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395961002565	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
395961002566	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
395961002567	putative active site [active]
395961002568	catalytic triad [active]
395961002569	putative dimer interface [polypeptide binding]; other site
395961002570	DevC protein; Region: devC; TIGR01185
395961002571	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395961002572	FtsX-like permease family; Region: FtsX; pfam02687
395961002573	TPR repeat; Region: TPR_11; pfam13414
395961002574	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961002575	binding surface
395961002576	TPR motif; other site
395961002577	TPR repeat; Region: TPR_11; pfam13414
395961002578	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395961002579	Cache domain; Region: Cache_1; pfam02743
395961002580	HAMP domain; Region: HAMP; pfam00672
395961002581	dimerization interface [polypeptide binding]; other site
395961002582	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961002583	Histidine kinase; Region: HisKA_2; pfam07568
395961002584	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961002585	ATP binding site [chemical binding]; other site
395961002586	Mg2+ binding site [ion binding]; other site
395961002587	G-X-G motif; other site
395961002588	Response regulator receiver domain; Region: Response_reg; pfam00072
395961002589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002590	active site
395961002591	phosphorylation site [posttranslational modification]
395961002592	intermolecular recognition site; other site
395961002593	dimerization interface [polypeptide binding]; other site
395961002594	PAS domain S-box; Region: sensory_box; TIGR00229
395961002595	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961002596	putative active site [active]
395961002597	heme pocket [chemical binding]; other site
395961002598	PAS fold; Region: PAS_4; pfam08448
395961002599	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961002600	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961002601	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961002602	PAS fold; Region: PAS_3; pfam08447
395961002603	putative active site [active]
395961002604	heme pocket [chemical binding]; other site
395961002605	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961002606	Histidine kinase; Region: HisKA_2; pfam07568
395961002607	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961002608	ATP binding site [chemical binding]; other site
395961002609	Mg2+ binding site [ion binding]; other site
395961002610	G-X-G motif; other site
395961002611	peptide chain release factor 1; Validated; Region: prfA; PRK00591
395961002612	This domain is found in peptide chain release factors; Region: PCRF; smart00937
395961002613	RF-1 domain; Region: RF-1; pfam00472
395961002614	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
395961002615	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
395961002616	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395961002617	RNA binding surface [nucleotide binding]; other site
395961002618	Haemolytic domain; Region: Haemolytic; pfam01809
395961002619	Ras GTPase Activating Domain; Region: RasGAP; cl02569
395961002620	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
395961002621	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
395961002622	dimerization interface [polypeptide binding]; other site
395961002623	DPS ferroxidase diiron center [ion binding]; other site
395961002624	ion pore; other site
395961002625	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
395961002626	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
395961002627	putative di-iron ligands [ion binding]; other site
395961002628	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961002629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961002630	proton extrusion protein PcxA; Provisional; Region: PRK02507
395961002631	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961002632	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961002633	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961002634	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961002635	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961002636	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
395961002637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961002638	S-adenosylmethionine binding site [chemical binding]; other site
395961002639	Glucanosyltransferase; Region: Glyco_hydro_72; pfam03198
395961002640	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
395961002641	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
395961002642	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
395961002643	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
395961002644	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
395961002645	PemK-like protein; Region: PemK; pfam02452
395961002646	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961002647	putative active site [active]
395961002648	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961002649	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
395961002650	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
395961002651	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
395961002652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961002653	S-adenosylmethionine binding site [chemical binding]; other site
395961002654	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
395961002655	active site
395961002656	metal-binding site [ion binding]
395961002657	nucleotide-binding site [chemical binding]; other site
395961002658	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
395961002659	active site
395961002660	dimer interface [polypeptide binding]; other site
395961002661	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
395961002662	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
395961002663	Ligand Binding Site [chemical binding]; other site
395961002664	Molecular Tunnel; other site
395961002665	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
395961002666	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
395961002667	2TM domain; Region: 2TM; pfam13239
395961002668	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
395961002669	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395961002670	putative substrate binding site [chemical binding]; other site
395961002671	putative ATP binding site [chemical binding]; other site
395961002672	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
395961002673	active site
395961002674	SAM binding site [chemical binding]; other site
395961002675	homodimer interface [polypeptide binding]; other site
395961002676	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
395961002677	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
395961002678	Phycobilisome protein; Region: Phycobilisome; cl08227
395961002679	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395961002680	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
395961002681	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
395961002682	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
395961002683	nudix motif; other site
395961002684	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395961002685	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395961002686	Walker A/P-loop; other site
395961002687	ATP binding site [chemical binding]; other site
395961002688	Q-loop/lid; other site
395961002689	ABC transporter signature motif; other site
395961002690	Walker B; other site
395961002691	D-loop; other site
395961002692	H-loop/switch region; other site
395961002693	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395961002694	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395961002695	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395961002696	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395961002697	TM-ABC transporter signature motif; other site
395961002698	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
395961002699	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
395961002700	Walker A/P-loop; other site
395961002701	ATP binding site [chemical binding]; other site
395961002702	Q-loop/lid; other site
395961002703	ABC transporter signature motif; other site
395961002704	Walker B; other site
395961002705	D-loop; other site
395961002706	H-loop/switch region; other site
395961002707	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
395961002708	PDGLE domain; Region: PDGLE; pfam13190
395961002709	cobalt transport protein CbiM; Validated; Region: PRK06265
395961002710	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
395961002711	Domain of unknown function (DUF305); Region: DUF305; pfam03713
395961002712	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
395961002713	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
395961002714	active site residue [active]
395961002715	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
395961002716	active site residue [active]
395961002717	DNA topoisomerase I; Validated; Region: PRK06599
395961002718	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
395961002719	active site
395961002720	metal binding site [ion binding]; metal-binding site
395961002721	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
395961002722	domain I; other site
395961002723	DNA binding groove [nucleotide binding]
395961002724	phosphate binding site [ion binding]; other site
395961002725	domain II; other site
395961002726	domain III; other site
395961002727	nucleotide binding site [chemical binding]; other site
395961002728	catalytic site [active]
395961002729	domain IV; other site
395961002730	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961002731	Coenzyme A binding pocket [chemical binding]; other site
395961002732	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
395961002733	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
395961002734	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
395961002735	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395961002736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002737	active site
395961002738	phosphorylation site [posttranslational modification]
395961002739	intermolecular recognition site; other site
395961002740	dimerization interface [polypeptide binding]; other site
395961002741	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395961002742	DNA binding residues [nucleotide binding]
395961002743	dimerization interface [polypeptide binding]; other site
395961002744	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961002745	putative active site [active]
395961002746	4-alpha-glucanotransferase; Provisional; Region: PRK14508
395961002747	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
395961002748	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
395961002749	G1 box; other site
395961002750	putative GEF interaction site [polypeptide binding]; other site
395961002751	GTP/Mg2+ binding site [chemical binding]; other site
395961002752	Switch I region; other site
395961002753	G2 box; other site
395961002754	G3 box; other site
395961002755	Switch II region; other site
395961002756	G4 box; other site
395961002757	G5 box; other site
395961002758	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
395961002759	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
395961002760	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395961002761	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
395961002762	active site
395961002763	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
395961002764	protein I interface; other site
395961002765	D2 interface; other site
395961002766	protein T interface; other site
395961002767	chlorophyll binding site; other site
395961002768	beta carotene binding site; other site
395961002769	pheophytin binding site; other site
395961002770	manganese-stabilizing polypeptide interface; other site
395961002771	CP43 interface; other site
395961002772	protein L interface; other site
395961002773	oxygen evolving complex binding site; other site
395961002774	bromide binding site; other site
395961002775	quinone binding site; other site
395961002776	Fe binding site [ion binding]; other site
395961002777	core light harvesting interface; other site
395961002778	cytochrome b559 alpha subunit interface; other site
395961002779	cytochrome c-550 interface; other site
395961002780	protein J interface; other site
395961002781	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395961002782	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395961002783	catalytic loop [active]
395961002784	iron binding site [ion binding]; other site
395961002785	Response regulator receiver domain; Region: Response_reg; pfam00072
395961002786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002787	active site
395961002788	phosphorylation site [posttranslational modification]
395961002789	intermolecular recognition site; other site
395961002790	dimerization interface [polypeptide binding]; other site
395961002791	Response regulator receiver domain; Region: Response_reg; pfam00072
395961002792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002793	active site
395961002794	phosphorylation site [posttranslational modification]
395961002795	intermolecular recognition site; other site
395961002796	dimerization interface [polypeptide binding]; other site
395961002797	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
395961002798	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961002799	dimerization interface [polypeptide binding]; other site
395961002800	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961002801	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961002802	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961002803	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961002804	Sec8 exocyst complex component specific domain; Region: Sec8_exocyst; pfam04048
395961002805	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395961002806	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395961002807	dimer interface [polypeptide binding]; other site
395961002808	putative CheW interface [polypeptide binding]; other site
395961002809	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
395961002810	putative binding surface; other site
395961002811	active site
395961002812	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
395961002813	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
395961002814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961002815	ATP binding site [chemical binding]; other site
395961002816	Mg2+ binding site [ion binding]; other site
395961002817	G-X-G motif; other site
395961002818	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
395961002819	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961002820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002821	active site
395961002822	phosphorylation site [posttranslational modification]
395961002823	intermolecular recognition site; other site
395961002824	dimerization interface [polypeptide binding]; other site
395961002825	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
395961002826	E3 Ubiquitin ligase; Region: GIDE; pfam12483
395961002827	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961002828	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961002829	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961002830	S-layer homology domain; Region: SLH; pfam00395
395961002831	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
395961002832	tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133
395961002833	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
395961002834	HIGH motif; other site
395961002835	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
395961002836	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
395961002837	active site
395961002838	KMSKS motif; other site
395961002839	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
395961002840	tRNA binding surface [nucleotide binding]; other site
395961002841	anticodon binding site; other site
395961002842	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
395961002843	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
395961002844	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
395961002845	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
395961002846	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
395961002847	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
395961002848	homooctamer interface [polypeptide binding]; other site
395961002849	active site
395961002850	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
395961002851	dimer interface [polypeptide binding]; other site
395961002852	active site
395961002853	Schiff base residues; other site
395961002854	EamA-like transporter family; Region: EamA; pfam00892
395961002855	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
395961002856	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
395961002857	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395961002858	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395961002859	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
395961002860	hydrolase, alpha/beta fold family protein; Region: PLN02824
395961002861	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961002862	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961002863	phosphopeptide binding site; other site
395961002864	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961002865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002866	active site
395961002867	phosphorylation site [posttranslational modification]
395961002868	intermolecular recognition site; other site
395961002869	dimerization interface [polypeptide binding]; other site
395961002870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961002871	AAA domain; Region: AAA_22; pfam13401
395961002872	Walker A motif; other site
395961002873	ATP binding site [chemical binding]; other site
395961002874	Walker B motif; other site
395961002875	arginine finger; other site
395961002876	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395961002877	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961002878	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395961002879	Predicted transcriptional regulators [Transcription]; Region: COG1725
395961002880	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395961002881	DNA-binding site [nucleotide binding]; DNA binding site
395961002882	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
395961002883	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
395961002884	HD domain; Region: HD; pfam01966
395961002885	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395961002886	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002887	active site
395961002888	phosphorylation site [posttranslational modification]
395961002889	intermolecular recognition site; other site
395961002890	dimerization interface [polypeptide binding]; other site
395961002891	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395961002892	DNA binding site [nucleotide binding]
395961002893	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961002894	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
395961002895	putative ADP-binding pocket [chemical binding]; other site
395961002896	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
395961002897	Chain length determinant protein; Region: Wzz; pfam02706
395961002898	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
395961002899	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961002900	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
395961002901	active site
395961002902	catalytic residues [active]
395961002903	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961002904	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961002905	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961002906	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961002907	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961002908	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
395961002909	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961002910	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961002911	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961002912	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961002913	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
395961002914	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
395961002915	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961002916	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961002917	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
395961002918	metal-binding site
395961002919	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
395961002920	trimer interface [polypeptide binding]; other site
395961002921	CoA binding site [chemical binding]; other site
395961002922	active site
395961002923	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961002924	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961002925	active site
395961002926	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
395961002927	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
395961002928	Walker A/P-loop; other site
395961002929	ATP binding site [chemical binding]; other site
395961002930	Q-loop/lid; other site
395961002931	ABC transporter signature motif; other site
395961002932	Walker B; other site
395961002933	D-loop; other site
395961002934	H-loop/switch region; other site
395961002935	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
395961002936	putative carbohydrate binding site [chemical binding]; other site
395961002937	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
395961002938	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395961002939	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395961002940	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
395961002941	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
395961002942	NADP-binding site; other site
395961002943	homotetramer interface [polypeptide binding]; other site
395961002944	substrate binding site [chemical binding]; other site
395961002945	homodimer interface [polypeptide binding]; other site
395961002946	active site
395961002947	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
395961002948	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961002949	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961002950	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961002951	Mg chelatase-related protein; Region: TIGR00368
395961002952	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
395961002953	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961002954	Walker A motif; other site
395961002955	ATP binding site [chemical binding]; other site
395961002956	Walker B motif; other site
395961002957	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
395961002958	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961002959	putative active site [active]
395961002960	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
395961002961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961002962	NAD(P) binding site [chemical binding]; other site
395961002963	active site
395961002964	GTP-binding protein LepA; Provisional; Region: PRK05433
395961002965	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
395961002966	G1 box; other site
395961002967	putative GEF interaction site [polypeptide binding]; other site
395961002968	GTP/Mg2+ binding site [chemical binding]; other site
395961002969	Switch I region; other site
395961002970	G2 box; other site
395961002971	G3 box; other site
395961002972	Switch II region; other site
395961002973	G4 box; other site
395961002974	G5 box; other site
395961002975	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
395961002976	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
395961002977	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
395961002978	TraB family; Region: TraB; pfam01963
395961002979	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
395961002980	PQQ-like domain; Region: PQQ_2; pfam13360
395961002981	Trp docking motif [polypeptide binding]; other site
395961002982	active site
395961002983	Ycf27; Reviewed; Region: orf27; CHL00148
395961002984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961002985	active site
395961002986	phosphorylation site [posttranslational modification]
395961002987	intermolecular recognition site; other site
395961002988	dimerization interface [polypeptide binding]; other site
395961002989	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395961002990	DNA binding site [nucleotide binding]
395961002991	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961002992	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961002993	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961002994	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
395961002995	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
395961002996	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
395961002997	EamA-like transporter family; Region: EamA; pfam00892
395961002998	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
395961002999	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
395961003000	TAP-like protein; Region: Abhydrolase_4; pfam08386
395961003001	MltA specific insert domain; Region: MltA; cl08398
395961003002	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
395961003003	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395961003004	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
395961003005	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
395961003006	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
395961003007	Chain length determinant protein; Region: Wzz; cl15801
395961003008	Chain length determinant protein; Region: Wzz; cl15801
395961003009	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
395961003010	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961003011	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
395961003012	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
395961003013	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
395961003014	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
395961003015	O-Antigen ligase; Region: Wzy_C; pfam04932
395961003016	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
395961003017	putative ADP-binding pocket [chemical binding]; other site
395961003018	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961003019	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961003020	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961003021	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
395961003022	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961003023	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961003024	active site
395961003025	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395961003026	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961003027	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961003028	Walker A/P-loop; other site
395961003029	ATP binding site [chemical binding]; other site
395961003030	Q-loop/lid; other site
395961003031	ABC transporter signature motif; other site
395961003032	Walker B; other site
395961003033	D-loop; other site
395961003034	H-loop/switch region; other site
395961003035	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
395961003036	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
395961003037	substrate binding site [chemical binding]; other site
395961003038	ligand binding site [chemical binding]; other site
395961003039	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
395961003040	Predicted permeases [General function prediction only]; Region: COG0701
395961003041	TIGR03943 family protein; Region: TIGR03943
395961003042	The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424
395961003043	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
395961003044	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
395961003045	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
395961003046	Peptidase family M23; Region: Peptidase_M23; pfam01551
395961003047	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
395961003048	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
395961003049	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
395961003050	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
395961003051	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395961003052	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395961003053	catalytic residues [active]
395961003054	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
395961003055	feedback inhibition sensing region; other site
395961003056	homohexameric interface [polypeptide binding]; other site
395961003057	nucleotide binding site [chemical binding]; other site
395961003058	N-acetyl-L-glutamate binding site [chemical binding]; other site
395961003059	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
395961003060	Peptidase family M48; Region: Peptidase_M48; cl12018
395961003061	Protein of unknown function DUF262; Region: DUF262; pfam03235
395961003062	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
395961003063	Bacterial Ig-like domain; Region: Big_5; pfam13205
395961003064	MG2 domain; Region: A2M_N; pfam01835
395961003065	Alpha-2-macroglobulin family; Region: A2M; pfam00207
395961003066	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
395961003067	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395961003068	active site
395961003069	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
395961003070	putative active site [active]
395961003071	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
395961003072	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
395961003073	trimer interface [polypeptide binding]; other site
395961003074	dimer interface [polypeptide binding]; other site
395961003075	putative active site [active]
395961003076	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
395961003077	DHH family; Region: DHH; pfam01368
395961003078	DHHA1 domain; Region: DHHA1; pfam02272
395961003079	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
395961003080	RNA/DNA hybrid binding site [nucleotide binding]; other site
395961003081	active site
395961003082	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
395961003083	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
395961003084	Transglycosylase; Region: Transgly; pfam00912
395961003085	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
395961003086	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
395961003087	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
395961003088	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961003089	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
395961003090	NAD(P) binding site [chemical binding]; other site
395961003091	putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366
395961003092	Predicted transcriptional regulators [Transcription]; Region: COG1733
395961003093	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395961003094	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395961003095	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395961003096	active site
395961003097	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
395961003098	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961003099	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
395961003100	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
395961003101	hexamer interface [polypeptide binding]; other site
395961003102	ligand binding site [chemical binding]; other site
395961003103	putative active site [active]
395961003104	NAD(P) binding site [chemical binding]; other site
395961003105	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961003106	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961003107	ligand binding site [chemical binding]; other site
395961003108	flexible hinge region; other site
395961003109	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
395961003110	Winged helix-turn helix; Region: HTH_29; pfam13551
395961003111	Homeodomain-like domain; Region: HTH_32; pfam13565
395961003112	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961003113	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961003114	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
395961003115	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
395961003116	iron-sulfur cluster [ion binding]; other site
395961003117	[2Fe-2S] cluster binding site [ion binding]; other site
395961003118	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
395961003119	hydrophobic ligand binding site; other site
395961003120	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
395961003121	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
395961003122	iron-sulfur cluster [ion binding]; other site
395961003123	[2Fe-2S] cluster binding site [ion binding]; other site
395961003124	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
395961003125	hydrophobic ligand binding site; other site
395961003126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961003127	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395961003128	putative substrate translocation pore; other site
395961003129	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
395961003130	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395961003131	active site
395961003132	metal binding site [ion binding]; metal-binding site
395961003133	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
395961003134	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
395961003135	putative substrate binding pocket [chemical binding]; other site
395961003136	catalytic triad [active]
395961003137	AB domain interface; other site
395961003138	Uncharacterized conserved protein [Function unknown]; Region: COG2836
395961003139	Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605
395961003140	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
395961003141	SprT homologues; Region: SprT; cl01182
395961003142	SprT-like family; Region: SprT-like; pfam10263
395961003143	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
395961003144	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
395961003145	putative active site [active]
395961003146	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
395961003147	putative active site [active]
395961003148	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395961003149	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395961003150	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
395961003151	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
395961003152	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
395961003153	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
395961003154	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
395961003155	Uncharacterized conserved protein [Function unknown]; Region: COG2361
395961003156	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395961003157	active site
395961003158	NTP binding site [chemical binding]; other site
395961003159	metal binding triad [ion binding]; metal-binding site
395961003160	antibiotic binding site [chemical binding]; other site
395961003161	acyl carrier protein; Provisional; Region: acpP; PRK00982
395961003162	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
395961003163	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
395961003164	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961003165	Walker A/P-loop; other site
395961003166	ATP binding site [chemical binding]; other site
395961003167	Q-loop/lid; other site
395961003168	ABC transporter signature motif; other site
395961003169	Walker B; other site
395961003170	D-loop; other site
395961003171	H-loop/switch region; other site
395961003172	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
395961003173	UbiA prenyltransferase family; Region: UbiA; pfam01040
395961003174	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
395961003175	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
395961003176	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
395961003177	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
395961003178	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
395961003179	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
395961003180	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
395961003181	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
395961003182	Subunit I/III interface [polypeptide binding]; other site
395961003183	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961003184	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961003185	active site
395961003186	phosphorylation site [posttranslational modification]
395961003187	intermolecular recognition site; other site
395961003188	dimerization interface [polypeptide binding]; other site
395961003189	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395961003190	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
395961003191	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
395961003192	NAD(P) binding site [chemical binding]; other site
395961003193	catalytic residues [active]
395961003194	Thioredoxin; Region: Thioredoxin_4; pfam13462
395961003195	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
395961003196	muropeptide transporter; Validated; Region: ampG; cl17669
395961003197	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961003198	PAS fold; Region: PAS_3; pfam08447
395961003199	putative active site [active]
395961003200	heme pocket [chemical binding]; other site
395961003201	GAF domain; Region: GAF; cl17456
395961003202	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961003203	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961003204	metal binding site [ion binding]; metal-binding site
395961003205	active site
395961003206	I-site; other site
395961003207	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961003208	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
395961003209	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
395961003210	putative active site [active]
395961003211	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
395961003212	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961003213	active site
395961003214	motif I; other site
395961003215	motif II; other site
395961003216	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
395961003217	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
395961003218	homotrimer interaction site [polypeptide binding]; other site
395961003219	putative active site [active]
395961003220	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
395961003221	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
395961003222	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961003223	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961003224	phosphopeptide binding site; other site
395961003225	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961003226	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961003227	active site
395961003228	ATP binding site [chemical binding]; other site
395961003229	substrate binding site [chemical binding]; other site
395961003230	activation loop (A-loop); other site
395961003231	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
395961003232	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
395961003233	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
395961003234	active site
395961003235	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
395961003236	pseudouridine synthase; Region: TIGR00093
395961003237	active site
395961003238	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961003239	putative active site [active]
395961003240	Cobalt transport protein; Region: CbiQ; cl00463
395961003241	anthranilate synthase component I-like protein; Validated; Region: PRK05940
395961003242	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
395961003243	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
395961003244	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
395961003245	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
395961003246	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395961003247	catalytic residue [active]
395961003248	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
395961003249	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
395961003250	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
395961003251	Catalytic site [active]
395961003252	ornithine carbamoyltransferase; Provisional; Region: PRK00779
395961003253	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
395961003254	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
395961003255	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
395961003256	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
395961003257	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395961003258	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395961003259	Protein of unknown function (DUF760); Region: DUF760; pfam05542
395961003260	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
395961003261	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
395961003262	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
395961003263	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
395961003264	homodimer interface [polypeptide binding]; other site
395961003265	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
395961003266	active site pocket [active]
395961003267	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
395961003268	active site
395961003269	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
395961003270	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395961003271	dimer interface [polypeptide binding]; other site
395961003272	active site
395961003273	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961003274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961003275	S-adenosylmethionine binding site [chemical binding]; other site
395961003276	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961003277	putative active site [active]
395961003278	Protein of unknown function (DUF433); Region: DUF433; cl01030
395961003279	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
395961003280	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
395961003281	dimer interface [polypeptide binding]; other site
395961003282	motif 1; other site
395961003283	active site
395961003284	motif 2; other site
395961003285	motif 3; other site
395961003286	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
395961003287	anticodon binding site; other site
395961003288	cell division topological specificity factor MinE; Provisional; Region: PRK13988
395961003289	septum site-determining protein MinD; Region: minD_bact; TIGR01968
395961003290	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
395961003291	P-loop; other site
395961003292	ADP binding residues [chemical binding]; other site
395961003293	Switch I; other site
395961003294	Switch II; other site
395961003295	septum formation inhibitor; Reviewed; Region: minC; PRK00513
395961003296	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
395961003297	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
395961003298	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
395961003299	active site
395961003300	homodimer interface [polypeptide binding]; other site
395961003301	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
395961003302	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395961003303	catalytic residues [active]
395961003304	CHAT domain; Region: CHAT; cl17868
395961003305	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
395961003306	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
395961003307	homodimer interface [polypeptide binding]; other site
395961003308	substrate-cofactor binding pocket; other site
395961003309	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961003310	catalytic residue [active]
395961003311	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
395961003312	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395961003313	NAD binding site [chemical binding]; other site
395961003314	homotetramer interface [polypeptide binding]; other site
395961003315	homodimer interface [polypeptide binding]; other site
395961003316	active site
395961003317	substrate binding site [chemical binding]; other site
395961003318	Predicted membrane protein [Function unknown]; Region: COG2246
395961003319	GtrA-like protein; Region: GtrA; pfam04138
395961003320	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
395961003321	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961003322	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961003323	S-adenosylmethionine binding site [chemical binding]; other site
395961003324	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
395961003325	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
395961003326	Ligand binding site; other site
395961003327	Putative Catalytic site; other site
395961003328	DXD motif; other site
395961003329	Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; pfam02427
395961003330	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
395961003331	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
395961003332	dimerization interface [polypeptide binding]; other site
395961003333	domain crossover interface; other site
395961003334	redox-dependent activation switch; other site
395961003335	Uncharacterized conserved protein [Function unknown]; Region: COG0432
395961003336	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
395961003337	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
395961003338	Walker A/P-loop; other site
395961003339	ATP binding site [chemical binding]; other site
395961003340	Q-loop/lid; other site
395961003341	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
395961003342	ABC transporter signature motif; other site
395961003343	Walker B; other site
395961003344	D-loop; other site
395961003345	H-loop/switch region; other site
395961003346	glutamate racemase; Provisional; Region: PRK00865
395961003347	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
395961003348	active site
395961003349	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
395961003350	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
395961003351	hinge; other site
395961003352	active site
395961003353	precorrin-8X methylmutase; Validated; Region: PRK05953
395961003354	Precorrin-8X methylmutase; Region: CbiC; pfam02570
395961003355	light-harvesting-like protein 3; Provisional; Region: PLN00014
395961003356	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
395961003357	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
395961003358	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961003359	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
395961003360	active site
395961003361	putative homodimer interface [polypeptide binding]; other site
395961003362	SAM binding site [chemical binding]; other site
395961003363	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
395961003364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961003365	S-adenosylmethionine binding site [chemical binding]; other site
395961003366	precorrin-8X methylmutase; Provisional; Region: PRK05954
395961003367	Precorrin-8X methylmutase; Region: CbiC; pfam02570
395961003368	Membrane transport protein; Region: Mem_trans; cl09117
395961003369	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
395961003370	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395961003371	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395961003372	active site
395961003373	metal binding site [ion binding]; metal-binding site
395961003374	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
395961003375	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
395961003376	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
395961003377	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
395961003378	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
395961003379	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
395961003380	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
395961003381	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
395961003382	putative translocon binding site; other site
395961003383	protein-rRNA interface [nucleotide binding]; other site
395961003384	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
395961003385	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
395961003386	G-X-X-G motif; other site
395961003387	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
395961003388	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
395961003389	23S rRNA interface [nucleotide binding]; other site
395961003390	5S rRNA interface [nucleotide binding]; other site
395961003391	putative antibiotic binding site [chemical binding]; other site
395961003392	L25 interface [polypeptide binding]; other site
395961003393	L27 interface [polypeptide binding]; other site
395961003394	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943
395961003395	ribosomal protein S17; Validated; Region: rps17; CHL00142
395961003396	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
395961003397	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
395961003398	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
395961003399	RNA binding site [nucleotide binding]; other site
395961003400	ribosomal protein L5; Region: rpl5; CHL00078
395961003401	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
395961003402	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
395961003403	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
395961003404	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
395961003405	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
395961003406	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
395961003407	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
395961003408	5S rRNA interface [nucleotide binding]; other site
395961003409	L5 interface [polypeptide binding]; other site
395961003410	ribosomal protein S5; Validated; Region: rps5; CHL00138
395961003411	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
395961003412	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
395961003413	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
395961003414	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
395961003415	SecY translocase; Region: SecY; pfam00344
395961003416	adenylate kinase; Reviewed; Region: adk; PRK00279
395961003417	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
395961003418	AMP-binding site [chemical binding]; other site
395961003419	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
395961003420	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
395961003421	rRNA binding site [nucleotide binding]; other site
395961003422	predicted 30S ribosome binding site; other site
395961003423	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
395961003424	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
395961003425	30S ribosomal protein S13; Region: bact_S13; TIGR03631
395961003426	30S ribosomal protein S11; Validated; Region: PRK05309
395961003427	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
395961003428	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
395961003429	alphaNTD homodimer interface [polypeptide binding]; other site
395961003430	alphaNTD - beta interaction site [polypeptide binding]; other site
395961003431	alphaNTD - beta' interaction site [polypeptide binding]; other site
395961003432	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
395961003433	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
395961003434	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
395961003435	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
395961003436	dimerization interface 3.5A [polypeptide binding]; other site
395961003437	active site
395961003438	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
395961003439	23S rRNA interface [nucleotide binding]; other site
395961003440	L3 interface [polypeptide binding]; other site
395961003441	ribosomal protein S9; Region: rps9; CHL00079
395961003442	ribosomal protein L31; Validated; Region: rpl31; CHL00136
395961003443	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
395961003444	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
395961003445	putative active site cavity [active]
395961003446	HEAT repeats; Region: HEAT_2; pfam13646
395961003447	HEAT repeats; Region: HEAT_2; pfam13646
395961003448	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
395961003449	HEAT repeats; Region: HEAT_2; pfam13646
395961003450	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961003451	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961003452	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961003453	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395961003454	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
395961003455	3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066
395961003456	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
395961003457	substrate binding site [chemical binding]; other site
395961003458	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395961003459	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961003460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961003461	S-adenosylmethionine binding site [chemical binding]; other site
395961003462	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395961003463	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961003464	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
395961003465	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
395961003466	acyl-activating enzyme (AAE) consensus motif; other site
395961003467	active site
395961003468	AMP binding site [chemical binding]; other site
395961003469	CoA binding site [chemical binding]; other site
395961003470	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467
395961003471	starch-binding site 2 [chemical binding]; other site
395961003472	starch-binding site 1 [chemical binding]; other site
395961003473	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
395961003474	active site
395961003475	catalytic triad [active]
395961003476	oxyanion hole [active]
395961003477	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
395961003478	Protein of unknown function (DUF433); Region: DUF433; pfam04255
395961003479	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961003480	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961003481	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961003482	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
395961003483	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961003484	FeS/SAM binding site; other site
395961003485	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
395961003486	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
395961003487	Peptidase family M50; Region: Peptidase_M50; pfam02163
395961003488	active site
395961003489	putative substrate binding region [chemical binding]; other site
395961003490	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
395961003491	FOG: CBS domain [General function prediction only]; Region: COG0517
395961003492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961003493	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395961003494	putative substrate translocation pore; other site
395961003495	ketol-acid reductoisomerase; Provisional; Region: PRK05479
395961003496	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
395961003497	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
395961003498	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
395961003499	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
395961003500	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
395961003501	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
395961003502	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
395961003503	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
395961003504	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
395961003505	YcfA-like protein; Region: YcfA; pfam07927
395961003506	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
395961003507	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
395961003508	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
395961003509	Nucleoside recognition; Region: Gate; pfam07670
395961003510	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
395961003511	prolyl-tRNA synthetase; Provisional; Region: PRK09194
395961003512	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
395961003513	dimer interface [polypeptide binding]; other site
395961003514	motif 1; other site
395961003515	active site
395961003516	motif 2; other site
395961003517	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
395961003518	putative deacylase active site [active]
395961003519	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395961003520	active site
395961003521	motif 3; other site
395961003522	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
395961003523	anticodon binding site; other site
395961003524	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
395961003525	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
395961003526	ABC-2 type transporter; Region: ABC2_membrane; cl17235
395961003527	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395961003528	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395961003529	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961003530	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
395961003531	Walker A/P-loop; other site
395961003532	ATP binding site [chemical binding]; other site
395961003533	Q-loop/lid; other site
395961003534	ABC transporter signature motif; other site
395961003535	Walker B; other site
395961003536	D-loop; other site
395961003537	H-loop/switch region; other site
395961003538	SnoaL-like domain; Region: SnoaL_3; pfam13474
395961003539	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
395961003540	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
395961003541	Tetramer interface [polypeptide binding]; other site
395961003542	active site
395961003543	FMN-binding site [chemical binding]; other site
395961003544	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
395961003545	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
395961003546	active site
395961003547	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
395961003548	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
395961003549	active site
395961003550	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
395961003551	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
395961003552	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
395961003553	minor groove reading motif; other site
395961003554	helix-hairpin-helix signature motif; other site
395961003555	substrate binding pocket [chemical binding]; other site
395961003556	active site
395961003557	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
395961003558	DNA gyrase subunit A; Validated; Region: PRK05560
395961003559	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
395961003560	CAP-like domain; other site
395961003561	active site
395961003562	primary dimer interface [polypeptide binding]; other site
395961003563	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395961003564	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395961003565	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395961003566	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395961003567	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
395961003568	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
395961003569	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
395961003570	putative RNA binding site [nucleotide binding]; other site
395961003571	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961003572	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961003573	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961003574	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961003575	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961003576	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961003577	putative active site [active]
395961003578	heme pocket [chemical binding]; other site
395961003579	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961003580	putative active site [active]
395961003581	heme pocket [chemical binding]; other site
395961003582	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961003583	PAS domain; Region: PAS_9; pfam13426
395961003584	putative active site [active]
395961003585	heme pocket [chemical binding]; other site
395961003586	PAS domain S-box; Region: sensory_box; TIGR00229
395961003587	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961003588	putative active site [active]
395961003589	heme pocket [chemical binding]; other site
395961003590	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961003591	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961003592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961003593	PAS fold; Region: PAS_3; pfam08447
395961003594	putative active site [active]
395961003595	heme pocket [chemical binding]; other site
395961003596	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961003597	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961003598	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961003599	Histidine kinase; Region: HisKA_2; pfam07568
395961003600	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961003601	ATP binding site [chemical binding]; other site
395961003602	Mg2+ binding site [ion binding]; other site
395961003603	G-X-G motif; other site
395961003604	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
395961003605	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
395961003606	active site
395961003607	substrate binding site [chemical binding]; other site
395961003608	metal binding site [ion binding]; metal-binding site
395961003609	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
395961003610	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
395961003611	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395961003612	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
395961003613	AAA domain; Region: AAA_26; pfam13500
395961003614	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
395961003615	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
395961003616	active site
395961003617	pyruvate kinase; Validated; Region: PRK08187
395961003618	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
395961003619	domain interfaces; other site
395961003620	active site
395961003621	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
395961003622	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
395961003623	IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603
395961003624	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
395961003625	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
395961003626	putative ligand binding site [chemical binding]; other site
395961003627	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
395961003628	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
395961003629	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
395961003630	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
395961003631	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
395961003632	Flavoprotein; Region: Flavoprotein; pfam02441
395961003633	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
395961003634	PhoD-like phosphatase; Region: PhoD; pfam09423
395961003635	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
395961003636	putative active site [active]
395961003637	putative metal binding site [ion binding]; other site
395961003638	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
395961003639	CTP synthetase; Validated; Region: pyrG; PRK05380
395961003640	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
395961003641	Catalytic site [active]
395961003642	active site
395961003643	UTP binding site [chemical binding]; other site
395961003644	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
395961003645	active site
395961003646	putative oxyanion hole; other site
395961003647	catalytic triad [active]
395961003648	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
395961003649	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395961003650	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395961003651	FOG: CBS domain [General function prediction only]; Region: COG0517
395961003652	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395961003653	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961003654	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961003655	PAS domain S-box; Region: sensory_box; TIGR00229
395961003656	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961003657	putative active site [active]
395961003658	heme pocket [chemical binding]; other site
395961003659	GAF domain; Region: GAF; pfam01590
395961003660	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961003661	PAS fold; Region: PAS_3; pfam08447
395961003662	putative active site [active]
395961003663	heme pocket [chemical binding]; other site
395961003664	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961003665	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961003666	putative active site [active]
395961003667	heme pocket [chemical binding]; other site
395961003668	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961003669	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961003670	putative active site [active]
395961003671	heme pocket [chemical binding]; other site
395961003672	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961003673	putative active site [active]
395961003674	heme pocket [chemical binding]; other site
395961003675	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961003676	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961003677	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961003678	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961003679	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961003680	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961003681	dimer interface [polypeptide binding]; other site
395961003682	phosphorylation site [posttranslational modification]
395961003683	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961003684	ATP binding site [chemical binding]; other site
395961003685	Mg2+ binding site [ion binding]; other site
395961003686	G-X-G motif; other site
395961003687	Response regulator receiver domain; Region: Response_reg; pfam00072
395961003688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961003689	active site
395961003690	phosphorylation site [posttranslational modification]
395961003691	intermolecular recognition site; other site
395961003692	dimerization interface [polypeptide binding]; other site
395961003693	Response regulator receiver domain; Region: Response_reg; pfam00072
395961003694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961003695	active site
395961003696	phosphorylation site [posttranslational modification]
395961003697	intermolecular recognition site; other site
395961003698	dimerization interface [polypeptide binding]; other site
395961003699	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961003700	Mg2+ binding site [ion binding]; other site
395961003701	G-X-G motif; other site
395961003702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961003703	active site
395961003704	phosphorylation site [posttranslational modification]
395961003705	intermolecular recognition site; other site
395961003706	dimerization interface [polypeptide binding]; other site
395961003707	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961003708	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961003709	metal binding site [ion binding]; metal-binding site
395961003710	active site
395961003711	I-site; other site
395961003712	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961003713	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
395961003714	PBP superfamily domain; Region: PBP_like_2; cl17296
395961003715	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395961003716	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
395961003717	FtsX-like permease family; Region: FtsX; pfam02687
395961003718	Peptidase family M23; Region: Peptidase_M23; pfam01551
395961003719	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395961003720	HlyD family secretion protein; Region: HlyD_3; pfam13437
395961003721	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
395961003722	dimer interface [polypeptide binding]; other site
395961003723	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
395961003724	Histidine kinase; Region: HisKA_3; pfam07730
395961003725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961003726	ATP binding site [chemical binding]; other site
395961003727	Mg2+ binding site [ion binding]; other site
395961003728	G-X-G motif; other site
395961003729	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395961003730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961003731	active site
395961003732	phosphorylation site [posttranslational modification]
395961003733	intermolecular recognition site; other site
395961003734	dimerization interface [polypeptide binding]; other site
395961003735	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395961003736	DNA binding residues [nucleotide binding]
395961003737	dimerization interface [polypeptide binding]; other site
395961003738	Zinc finger domain; Region: ZnF_RBZ; smart00547
395961003739	Double zinc ribbon; Region: DZR; pfam12773
395961003740	PBP superfamily domain; Region: PBP_like_2; pfam12849
395961003741	CsbD-like; Region: CsbD; cl17424
395961003742	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
395961003743	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
395961003744	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
395961003745	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
395961003746	Ligand Binding Site [chemical binding]; other site
395961003747	TIGR00269 family protein; Region: TIGR00269
395961003748	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
395961003749	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
395961003750	dimerization interface [polypeptide binding]; other site
395961003751	DPS ferroxidase diiron center [ion binding]; other site
395961003752	ion pore; other site
395961003753	hydrolase, alpha/beta fold family protein; Region: PLN02824
395961003754	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395961003755	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
395961003756	active site
395961003757	putative substrate binding region [chemical binding]; other site
395961003758	FOG: CBS domain [General function prediction only]; Region: COG0517
395961003759	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395961003760	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
395961003761	Predicted membrane protein [Function unknown]; Region: COG2119
395961003762	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
395961003763	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
395961003764	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
395961003765	apocytochrome f; Reviewed; Region: PRK02693
395961003766	cytochrome f; Region: petA; CHL00037
395961003767	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
395961003768	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
395961003769	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
395961003770	cytochrome b subunit interaction site [polypeptide binding]; other site
395961003771	[2Fe-2S] cluster binding site [ion binding]; other site
395961003772	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
395961003773	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961003774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961003775	active site
395961003776	phosphorylation site [posttranslational modification]
395961003777	intermolecular recognition site; other site
395961003778	dimerization interface [polypeptide binding]; other site
395961003779	Response regulator receiver domain; Region: Response_reg; pfam00072
395961003780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961003781	active site
395961003782	phosphorylation site [posttranslational modification]
395961003783	intermolecular recognition site; other site
395961003784	dimerization interface [polypeptide binding]; other site
395961003785	Response regulator receiver domain; Region: Response_reg; pfam00072
395961003786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961003787	active site
395961003788	phosphorylation site [posttranslational modification]
395961003789	intermolecular recognition site; other site
395961003790	dimerization interface [polypeptide binding]; other site
395961003791	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
395961003792	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961003793	dimerization interface [polypeptide binding]; other site
395961003794	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395961003795	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395961003796	dimer interface [polypeptide binding]; other site
395961003797	putative CheW interface [polypeptide binding]; other site
395961003798	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961003799	dimerization interface [polypeptide binding]; other site
395961003800	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395961003801	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395961003802	dimer interface [polypeptide binding]; other site
395961003803	putative CheW interface [polypeptide binding]; other site
395961003804	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
395961003805	putative binding surface; other site
395961003806	active site
395961003807	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
395961003808	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
395961003809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961003810	ATP binding site [chemical binding]; other site
395961003811	Mg2+ binding site [ion binding]; other site
395961003812	G-X-G motif; other site
395961003813	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
395961003814	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961003815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961003816	active site
395961003817	phosphorylation site [posttranslational modification]
395961003818	intermolecular recognition site; other site
395961003819	dimerization interface [polypeptide binding]; other site
395961003820	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
395961003821	Response regulator receiver domain; Region: Response_reg; pfam00072
395961003822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961003823	active site
395961003824	phosphorylation site [posttranslational modification]
395961003825	intermolecular recognition site; other site
395961003826	dimerization interface [polypeptide binding]; other site
395961003827	HEAT repeats; Region: HEAT_2; pfam13646
395961003828	HEAT repeats; Region: HEAT_2; pfam13646
395961003829	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
395961003830	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
395961003831	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
395961003832	protein binding site [polypeptide binding]; other site
395961003833	Chlorite dismutase; Region: Chlor_dismutase; cl01280
395961003834	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961003835	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961003836	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961003837	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961003838	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961003839	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
395961003840	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
395961003841	GatB domain; Region: GatB_Yqey; smart00845
395961003842	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
395961003843	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
395961003844	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395961003845	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395961003846	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
395961003847	nucleoside/Zn binding site; other site
395961003848	dimer interface [polypeptide binding]; other site
395961003849	catalytic motif [active]
395961003850	S-layer homology domain; Region: SLH; pfam00395
395961003851	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
395961003852	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395961003853	Sulfatase; Region: Sulfatase; pfam00884
395961003854	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
395961003855	putative amphipathic alpha helix; other site
395961003856	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
395961003857	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395961003858	SurA N-terminal domain; Region: SurA_N; pfam09312
395961003859	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395961003860	Predicted membrane protein [Function unknown]; Region: COG4803
395961003861	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395961003862	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395961003863	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
395961003864	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
395961003865	purine monophosphate binding site [chemical binding]; other site
395961003866	dimer interface [polypeptide binding]; other site
395961003867	putative catalytic residues [active]
395961003868	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
395961003869	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
395961003870	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
395961003871	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395961003872	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395961003873	active site
395961003874	metal binding site [ion binding]; metal-binding site
395961003875	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
395961003876	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395961003877	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395961003878	TPR repeat; Region: TPR_11; pfam13414
395961003879	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961003880	TPR motif; other site
395961003881	binding surface
395961003882	TPR repeat; Region: TPR_11; pfam13414
395961003883	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395961003884	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
395961003885	putative ribose interaction site [chemical binding]; other site
395961003886	putative ADP binding site [chemical binding]; other site
395961003887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395961003888	active site
395961003889	phosphorylation site [posttranslational modification]
395961003890	intermolecular recognition site; other site
395961003891	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
395961003892	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
395961003893	substrate binding site [chemical binding]; other site
395961003894	active site
395961003895	catalytic residues [active]
395961003896	heterodimer interface [polypeptide binding]; other site
395961003897	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
395961003898	Synechococcus sp. strain PCC 7942  PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162
395961003899	putative active site [active]
395961003900	putative metal binding site [ion binding]; other site
395961003901	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
395961003902	CARDB; Region: CARDB; pfam07705
395961003903	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
395961003904	proline aminopeptidase P II; Provisional; Region: PRK10879
395961003905	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
395961003906	active site
395961003907	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
395961003908	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395961003909	active site
395961003910	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
395961003911	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
395961003912	dimer interface [polypeptide binding]; other site
395961003913	ssDNA binding site [nucleotide binding]; other site
395961003914	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395961003915	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
395961003916	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
395961003917	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
395961003918	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
395961003919	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
395961003920	pyrroline-5-carboxylate reductase; Region: PLN02688
395961003921	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
395961003922	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
395961003923	Dehydroquinase class II; Region: DHquinase_II; pfam01220
395961003924	trimer interface [polypeptide binding]; other site
395961003925	active site
395961003926	dimer interface [polypeptide binding]; other site
395961003927	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
395961003928	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
395961003929	active site
395961003930	metal binding site [ion binding]; metal-binding site
395961003931	DNA binding site [nucleotide binding]
395961003932	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
395961003933	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395961003934	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
395961003935	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
395961003936	23S rRNA binding site [nucleotide binding]; other site
395961003937	L21 binding site [polypeptide binding]; other site
395961003938	L13 binding site [polypeptide binding]; other site
395961003939	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
395961003940	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395961003941	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395961003942	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
395961003943	YGGT family; Region: YGGT; pfam02325
395961003944	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
395961003945	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
395961003946	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
395961003947	ATP synthase I chain; Region: ATP_synt_I; pfam03899
395961003948	ATP synthase CF0 A subunit; Region: atpI; CHL00046
395961003949	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
395961003950	F0F1 ATP synthase subunit C; Validated; Region: PRK07354
395961003951	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
395961003952	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
395961003953	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
395961003954	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
395961003955	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
395961003956	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
395961003957	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
395961003958	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
395961003959	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
395961003960	beta subunit interaction interface [polypeptide binding]; other site
395961003961	Walker A motif; other site
395961003962	ATP binding site [chemical binding]; other site
395961003963	Walker B motif; other site
395961003964	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
395961003965	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
395961003966	core domain interface [polypeptide binding]; other site
395961003967	delta subunit interface [polypeptide binding]; other site
395961003968	epsilon subunit interface [polypeptide binding]; other site
395961003969	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961003970	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961003971	ligand binding site [chemical binding]; other site
395961003972	flexible hinge region; other site
395961003973	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
395961003974	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961003975	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395961003976	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961003977	non-specific DNA binding site [nucleotide binding]; other site
395961003978	sequence-specific DNA binding site [nucleotide binding]; other site
395961003979	salt bridge; other site
395961003980	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
395961003981	ABC1 family; Region: ABC1; cl17513
395961003982	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
395961003983	protein I interface; other site
395961003984	D2 interface; other site
395961003985	protein T interface; other site
395961003986	chlorophyll binding site; other site
395961003987	beta carotene binding site; other site
395961003988	pheophytin binding site; other site
395961003989	manganese-stabilizing polypeptide interface; other site
395961003990	CP43 interface; other site
395961003991	protein L interface; other site
395961003992	oxygen evolving complex binding site; other site
395961003993	bromide binding site; other site
395961003994	quinone binding site; other site
395961003995	Fe binding site [ion binding]; other site
395961003996	core light harvesting interface; other site
395961003997	cytochrome b559 alpha subunit interface; other site
395961003998	cytochrome c-550 interface; other site
395961003999	protein J interface; other site
395961004000	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
395961004001	nucleotide binding site/active site [active]
395961004002	Protein of unknown function (DUF561); Region: DUF561; pfam04481
395961004003	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
395961004004	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
395961004005	active site
395961004006	Substrate binding site; other site
395961004007	Mg++ binding site; other site
395961004008	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395961004009	putative trimer interface [polypeptide binding]; other site
395961004010	putative CoA binding site [chemical binding]; other site
395961004011	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
395961004012	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
395961004013	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
395961004014	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
395961004015	dimer interface [polypeptide binding]; other site
395961004016	ssDNA binding site [nucleotide binding]; other site
395961004017	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395961004018	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
395961004019	CAAX protease self-immunity; Region: Abi; pfam02517
395961004020	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395961004021	catalytic core [active]
395961004022	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395961004023	catalytic core [active]
395961004024	dihydroorotase; Provisional; Region: PRK07369
395961004025	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395961004026	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
395961004027	active site
395961004028	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
395961004029	nudix motif; other site
395961004030	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
395961004031	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395961004032	catalytic triad [active]
395961004033	Predicted permeases [General function prediction only]; Region: COG0795
395961004034	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
395961004035	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
395961004036	Part of AAA domain; Region: AAA_19; pfam13245
395961004037	Family description; Region: UvrD_C_2; pfam13538
395961004038	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
395961004039	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
395961004040	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395961004041	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
395961004042	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395961004043	DNA binding residues [nucleotide binding]
395961004044	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
395961004045	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
395961004046	NodB motif; other site
395961004047	active site
395961004048	catalytic site [active]
395961004049	metal binding site [ion binding]; metal-binding site
395961004050	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
395961004051	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961004052	FeS/SAM binding site; other site
395961004053	HemN C-terminal domain; Region: HemN_C; pfam06969
395961004054	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
395961004055	ATP-NAD kinase; Region: NAD_kinase; pfam01513
395961004056	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
395961004057	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
395961004058	oligomer interface [polypeptide binding]; other site
395961004059	active site residues [active]
395961004060	Clp protease; Region: CLP_protease; pfam00574
395961004061	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
395961004062	oligomer interface [polypeptide binding]; other site
395961004063	active site residues [active]
395961004064	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395961004065	HSP70 interaction site [polypeptide binding]; other site
395961004066	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
395961004067	putative active site pocket [active]
395961004068	dimerization interface [polypeptide binding]; other site
395961004069	putative catalytic residue [active]
395961004070	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395961004071	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
395961004072	HlyD family secretion protein; Region: HlyD_3; pfam13437
395961004073	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
395961004074	Protein export membrane protein; Region: SecD_SecF; cl14618
395961004075	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395961004076	proton extrusion protein PcxA; Provisional; Region: PRK02507
395961004077	hypothetical protein; Provisional; Region: PRK06847
395961004078	hypothetical protein; Provisional; Region: PRK07236
395961004079	NADH(P)-binding; Region: NAD_binding_10; pfam13460
395961004080	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961004081	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
395961004082	NADH(P)-binding; Region: NAD_binding_10; pfam13460
395961004083	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961004084	active site
395961004085	BioY family; Region: BioY; pfam02632
395961004086	biotin synthase; Region: bioB; TIGR00433
395961004087	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961004088	FeS/SAM binding site; other site
395961004089	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
395961004090	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
395961004091	amidase catalytic site [active]
395961004092	Zn binding residues [ion binding]; other site
395961004093	substrate binding site [chemical binding]; other site
395961004094	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961004095	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961004096	ligand binding site [chemical binding]; other site
395961004097	flexible hinge region; other site
395961004098	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395961004099	putative switch regulator; other site
395961004100	non-specific DNA interactions [nucleotide binding]; other site
395961004101	DNA binding site [nucleotide binding]
395961004102	sequence specific DNA binding site [nucleotide binding]; other site
395961004103	putative cAMP binding site [chemical binding]; other site
395961004104	methionine aminopeptidase; Provisional; Region: PRK08671
395961004105	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
395961004106	active site
395961004107	putative L-aspartate dehydrogenase; Provisional; Region: PRK13301
395961004108	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
395961004109	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
395961004110	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395961004111	catalytic core [active]
395961004112	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395961004113	substrate binding pocket [chemical binding]; other site
395961004114	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395961004115	membrane-bound complex binding site; other site
395961004116	hinge residues; other site
395961004117	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
395961004118	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
395961004119	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
395961004120	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
395961004121	dimer interface [polypeptide binding]; other site
395961004122	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961004123	catalytic residue [active]
395961004124	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
395961004125	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
395961004126	active site
395961004127	homodimer interface [polypeptide binding]; other site
395961004128	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
395961004129	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
395961004130	Walker A motif; other site
395961004131	ATP binding site [chemical binding]; other site
395961004132	Walker B motif; other site
395961004133	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
395961004134	tetramer interface [polypeptide binding]; other site
395961004135	dimer interface [polypeptide binding]; other site
395961004136	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395961004137	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395961004138	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961004139	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961004140	ligand binding site [chemical binding]; other site
395961004141	flexible hinge region; other site
395961004142	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
395961004143	cyclase homology domain; Region: CHD; cd07302
395961004144	dimer interface [polypeptide binding]; other site
395961004145	nucleotidyl binding site; other site
395961004146	metal binding site [ion binding]; metal-binding site
395961004147	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961004148	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961004149	phosphopeptide binding site; other site
395961004150	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961004151	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961004152	phosphopeptide binding site; other site
395961004153	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961004154	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961004155	phosphopeptide binding site; other site
395961004156	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
395961004157	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
395961004158	Walker A/P-loop; other site
395961004159	ATP binding site [chemical binding]; other site
395961004160	Q-loop/lid; other site
395961004161	ABC transporter signature motif; other site
395961004162	Walker B; other site
395961004163	D-loop; other site
395961004164	H-loop/switch region; other site
395961004165	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395961004166	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
395961004167	Circadian oscillating protein COP23; Region: COP23; pfam14218
395961004168	Circadian oscillating protein COP23; Region: COP23; pfam14218
395961004169	Circadian oscillating protein COP23; Region: COP23; pfam14218
395961004170	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395961004171	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395961004172	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961004173	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961004174	active site
395961004175	ATP binding site [chemical binding]; other site
395961004176	substrate binding site [chemical binding]; other site
395961004177	activation loop (A-loop); other site
395961004178	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
395961004179	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961004180	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961004181	active site
395961004182	ATP binding site [chemical binding]; other site
395961004183	substrate binding site [chemical binding]; other site
395961004184	activation loop (A-loop); other site
395961004185	Surface antigen; Region: Bac_surface_Ag; pfam01103
395961004186	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
395961004187	Putative catalytic domain of uncharacterized hypothetical proteins closely related to Nuc, , an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar2; cd09174
395961004188	PLD-like domain; Region: PLDc_2; pfam13091
395961004189	putative active site [active]
395961004190	catalytic site [active]
395961004191	GTP-binding protein Der; Reviewed; Region: PRK00093
395961004192	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
395961004193	G1 box; other site
395961004194	GTP/Mg2+ binding site [chemical binding]; other site
395961004195	Switch I region; other site
395961004196	G2 box; other site
395961004197	Switch II region; other site
395961004198	G3 box; other site
395961004199	G4 box; other site
395961004200	G5 box; other site
395961004201	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
395961004202	G1 box; other site
395961004203	GTP/Mg2+ binding site [chemical binding]; other site
395961004204	Switch I region; other site
395961004205	G2 box; other site
395961004206	G3 box; other site
395961004207	Switch II region; other site
395961004208	G4 box; other site
395961004209	G5 box; other site
395961004210	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
395961004211	cyclase homology domain; Region: CHD; cd07302
395961004212	nucleotidyl binding site; other site
395961004213	metal binding site [ion binding]; metal-binding site
395961004214	dimer interface [polypeptide binding]; other site
395961004215	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961004216	Uncharacterized conserved protein [Function unknown]; Region: COG3595
395961004217	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961004218	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961004219	dimerization interface [polypeptide binding]; other site
395961004220	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961004221	dimer interface [polypeptide binding]; other site
395961004222	phosphorylation site [posttranslational modification]
395961004223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961004224	ATP binding site [chemical binding]; other site
395961004225	Mg2+ binding site [ion binding]; other site
395961004226	G-X-G motif; other site
395961004227	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395961004228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961004229	active site
395961004230	phosphorylation site [posttranslational modification]
395961004231	intermolecular recognition site; other site
395961004232	dimerization interface [polypeptide binding]; other site
395961004233	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395961004234	DNA binding site [nucleotide binding]
395961004235	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
395961004236	Protein of unknown function (DUF98); Region: DUF98; pfam01947
395961004237	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
395961004238	L-aspartate oxidase; Provisional; Region: PRK06175
395961004239	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
395961004240	Chorismate mutase type II; Region: CM_2; cl00693
395961004241	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961004242	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
395961004243	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395961004244	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
395961004245	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
395961004246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961004247	ATP binding site [chemical binding]; other site
395961004248	Mg2+ binding site [ion binding]; other site
395961004249	G-X-G motif; other site
395961004250	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
395961004251	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
395961004252	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
395961004253	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
395961004254	aspartate aminotransferase; Provisional; Region: PRK05957
395961004255	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395961004256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961004257	homodimer interface [polypeptide binding]; other site
395961004258	catalytic residue [active]
395961004259	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
395961004260	C-terminal peptidase (prc); Region: prc; TIGR00225
395961004261	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
395961004262	protein binding site [polypeptide binding]; other site
395961004263	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
395961004264	Domain interface; other site
395961004265	Peptide binding site; other site
395961004266	Active site tetrad [active]
395961004267	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
395961004268	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
395961004269	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395961004270	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
395961004271	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
395961004272	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395961004273	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
395961004274	Double zinc ribbon; Region: DZR; pfam12773
395961004275	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
395961004276	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961004277	active site
395961004278	ATP binding site [chemical binding]; other site
395961004279	substrate binding site [chemical binding]; other site
395961004280	activation loop (A-loop); other site
395961004281	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395961004282	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961004283	structural tetrad; other site
395961004284	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395961004285	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
395961004286	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
395961004287	RNA polymerase sigma factor; Validated; Region: PRK05949
395961004288	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
395961004289	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395961004290	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
395961004291	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395961004292	DNA binding residues [nucleotide binding]
395961004293	HAS barrel domain; Region: HAS-barrel; pfam09378
395961004294	HerA helicase [Replication, recombination, and repair]; Region: COG0433
395961004295	Domain of unknown function DUF87; Region: DUF87; pfam01935
395961004296	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
395961004297	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961004298	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
395961004299	nif11-like leader peptide domain; Region: ocin_TIGR03798
395961004300	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
395961004301	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
395961004302	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
395961004303	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
395961004304	ligand binding site [chemical binding]; other site
395961004305	flexible hinge region; other site
395961004306	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961004307	ligand binding site [chemical binding]; other site
395961004308	flexible hinge region; other site
395961004309	Cupin domain; Region: Cupin_2; pfam07883
395961004310	DJ-1 family protein; Region: not_thiJ; TIGR01383
395961004311	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
395961004312	conserved cys residue [active]
395961004313	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
395961004314	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961004315	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
395961004316	catalytic triad [active]
395961004317	dimer interface [polypeptide binding]; other site
395961004318	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395961004319	metal binding site 2 [ion binding]; metal-binding site
395961004320	putative DNA binding helix; other site
395961004321	metal binding site 1 [ion binding]; metal-binding site
395961004322	dimer interface [polypeptide binding]; other site
395961004323	structural Zn2+ binding site [ion binding]; other site
395961004324	hypothetical protein; Provisional; Region: PRK07394
395961004325	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
395961004326	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
395961004327	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395961004328	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395961004329	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395961004330	dimerization interface [polypeptide binding]; other site
395961004331	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
395961004332	dimanganese center [ion binding]; other site
395961004333	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
395961004334	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961004335	S-adenosylmethionine binding site [chemical binding]; other site
395961004336	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
395961004337	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
395961004338	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
395961004339	ligand binding site; other site
395961004340	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395961004341	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961004342	active site
395961004343	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
395961004344	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
395961004345	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
395961004346	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
395961004347	16S/18S rRNA binding site [nucleotide binding]; other site
395961004348	S13e-L30e interaction site [polypeptide binding]; other site
395961004349	25S rRNA binding site [nucleotide binding]; other site
395961004350	Uncharacterized conserved protein [Function unknown]; Region: COG4279
395961004351	SNF2 Helicase protein; Region: DUF3670; pfam12419
395961004352	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
395961004353	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961004354	ATP binding site [chemical binding]; other site
395961004355	putative Mg++ binding site [ion binding]; other site
395961004356	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961004357	nucleotide binding region [chemical binding]; other site
395961004358	ATP-binding site [chemical binding]; other site
395961004359	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961004360	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004361	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004362	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004363	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
395961004364	DNA protecting protein DprA; Region: dprA; TIGR00732
395961004365	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
395961004366	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
395961004367	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
395961004368	Hexamer interface [polypeptide binding]; other site
395961004369	Hexagonal pore residue; other site
395961004370	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
395961004371	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
395961004372	Hexamer interface [polypeptide binding]; other site
395961004373	Hexagonal pore residue; other site
395961004374	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395961004375	putative trimer interface [polypeptide binding]; other site
395961004376	putative CoA binding site [chemical binding]; other site
395961004377	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
395961004378	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
395961004379	trimer interface [polypeptide binding]; other site
395961004380	active site
395961004381	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
395961004382	putative multimerization interface [polypeptide binding]; other site
395961004383	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
395961004384	putative multimerization interface [polypeptide binding]; other site
395961004385	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
395961004386	putative multimerization interface [polypeptide binding]; other site
395961004387	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cl01843
395961004388	putative multimerization interface [polypeptide binding]; other site
395961004389	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
395961004390	Hexamer/Pentamer interface [polypeptide binding]; other site
395961004391	central pore; other site
395961004392	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
395961004393	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
395961004394	Hexamer interface [polypeptide binding]; other site
395961004395	Hexagonal pore residue; other site
395961004396	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
395961004397	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
395961004398	Hexamer interface [polypeptide binding]; other site
395961004399	Hexagonal pore residue; other site
395961004400	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
395961004401	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
395961004402	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395961004403	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
395961004404	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395961004405	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
395961004406	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
395961004407	2TM domain; Region: 2TM; pfam13239
395961004408	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
395961004409	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
395961004410	Moco binding site; other site
395961004411	metal coordination site [ion binding]; other site
395961004412	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
395961004413	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
395961004414	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
395961004415	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
395961004416	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961004417	binding surface
395961004418	TPR repeat; Region: TPR_11; pfam13414
395961004419	TPR motif; other site
395961004420	TPR repeat; Region: TPR_11; pfam13414
395961004421	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395961004422	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961004423	binding surface
395961004424	TPR motif; other site
395961004425	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961004426	TPR motif; other site
395961004427	binding surface
395961004428	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961004429	TPR motif; other site
395961004430	binding surface
395961004431	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
395961004432	elongation factor G; Reviewed; Region: PRK12740
395961004433	G1 box; other site
395961004434	putative GEF interaction site [polypeptide binding]; other site
395961004435	GTP/Mg2+ binding site [chemical binding]; other site
395961004436	Switch I region; other site
395961004437	G2 box; other site
395961004438	G3 box; other site
395961004439	Switch II region; other site
395961004440	G4 box; other site
395961004441	G5 box; other site
395961004442	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
395961004443	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
395961004444	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
395961004445	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
395961004446	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395961004447	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961004448	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
395961004449	ThiS interaction site; other site
395961004450	putative active site [active]
395961004451	tetramer interface [polypeptide binding]; other site
395961004452	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
395961004453	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395961004454	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395961004455	DNA binding residues [nucleotide binding]
395961004456	Putative zinc-finger; Region: zf-HC2; pfam13490
395961004457	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
395961004458	UbiA prenyltransferase family; Region: UbiA; pfam01040
395961004459	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961004460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961004461	active site
395961004462	intermolecular recognition site; other site
395961004463	dimerization interface [polypeptide binding]; other site
395961004464	Phytase; Region: Phytase; cl17685
395961004465	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
395961004466	dimer interface [polypeptide binding]; other site
395961004467	substrate binding site [chemical binding]; other site
395961004468	metal binding sites [ion binding]; metal-binding site
395961004469	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
395961004470	putative active site [active]
395961004471	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
395961004472	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
395961004473	putative NAD(P) binding site [chemical binding]; other site
395961004474	homodimer interface [polypeptide binding]; other site
395961004475	homotetramer interface [polypeptide binding]; other site
395961004476	active site
395961004477	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
395961004478	proposed catalytic triad [active]
395961004479	active site nucleophile [active]
395961004480	Uncharacterized conserved protein [Function unknown]; Region: COG4715
395961004481	SWIM zinc finger; Region: SWIM; pfam04434
395961004482	Paxillin family; Region: Paxillin; pfam03535
395961004483	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
395961004484	metal-binding site [ion binding]
395961004485	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
395961004486	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
395961004487	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
395961004488	metal binding site [ion binding]; metal-binding site
395961004489	ChaB; Region: ChaB; cl01887
395961004490	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
395961004491	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
395961004492	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
395961004493	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
395961004494	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
395961004495	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
395961004496	Catalytic site [active]
395961004497	dihydroorotase; Provisional; Region: PRK07575
395961004498	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395961004499	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
395961004500	active site
395961004501	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004502	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961004503	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004504	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004505	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004506	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004507	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004508	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004509	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004510	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004511	geranylgeranyl reductase; Region: ChlP; TIGR02028
395961004512	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395961004513	citrate synthase; Provisional; Region: PRK14036
395961004514	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
395961004515	oxalacetate binding site [chemical binding]; other site
395961004516	citrylCoA binding site [chemical binding]; other site
395961004517	coenzyme A binding site [chemical binding]; other site
395961004518	catalytic triad [active]
395961004519	NADH dehydrogenase; Region: NADHdh; cl00469
395961004520	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
395961004521	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
395961004522	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
395961004523	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
395961004524	NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015
395961004525	gamma-glutamyl kinase; Provisional; Region: PRK05429
395961004526	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
395961004527	nucleotide binding site [chemical binding]; other site
395961004528	homotetrameric interface [polypeptide binding]; other site
395961004529	putative phosphate binding site [ion binding]; other site
395961004530	putative allosteric binding site; other site
395961004531	PUA domain; Region: PUA; pfam01472
395961004532	recombinase A; Provisional; Region: recA; PRK09354
395961004533	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
395961004534	hexamer interface [polypeptide binding]; other site
395961004535	Walker A motif; other site
395961004536	ATP binding site [chemical binding]; other site
395961004537	Walker B motif; other site
395961004538	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
395961004539	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395961004540	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395961004541	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
395961004542	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395961004543	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395961004544	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
395961004545	IMP binding site; other site
395961004546	dimer interface [polypeptide binding]; other site
395961004547	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
395961004548	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
395961004549	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395961004550	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
395961004551	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395961004552	DNA binding residues [nucleotide binding]
395961004553	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
395961004554	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
395961004555	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
395961004556	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
395961004557	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
395961004558	active site
395961004559	SAM binding site [chemical binding]; other site
395961004560	homodimer interface [polypeptide binding]; other site
395961004561	competence damage-inducible protein A; Provisional; Region: PRK00549
395961004562	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
395961004563	putative MPT binding site; other site
395961004564	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
395961004565	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
395961004566	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
395961004567	Mg++ binding site [ion binding]; other site
395961004568	putative catalytic motif [active]
395961004569	substrate binding site [chemical binding]; other site
395961004570	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
395961004571	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
395961004572	dimer interface [polypeptide binding]; other site
395961004573	active site
395961004574	glycine-pyridoxal phosphate binding site [chemical binding]; other site
395961004575	folate binding site [chemical binding]; other site
395961004576	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
395961004577	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
395961004578	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
395961004579	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
395961004580	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
395961004581	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
395961004582	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395961004583	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
395961004584	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
395961004585	FAD binding site [chemical binding]; other site
395961004586	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395961004587	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395961004588	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395961004589	N-terminal domain interface [polypeptide binding]; other site
395961004590	substrate binding pocket (H-site) [chemical binding]; other site
395961004591	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395961004592	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961004593	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
395961004594	HEAT repeats; Region: HEAT_2; pfam13646
395961004595	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
395961004596	HEAT repeats; Region: HEAT_2; pfam13646
395961004597	HEAT repeats; Region: HEAT_2; pfam13646
395961004598	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
395961004599	protein binding surface [polypeptide binding]; other site
395961004600	HEAT repeats; Region: HEAT_2; pfam13646
395961004601	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
395961004602	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
395961004603	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
395961004604	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
395961004605	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
395961004606	Phycobilisome protein; Region: Phycobilisome; cl08227
395961004607	Phycobilisome protein; Region: Phycobilisome; cl08227
395961004608	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
395961004609	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
395961004610	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
395961004611	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
395961004612	putative hexamer interface [polypeptide binding]; other site
395961004613	putative hexagonal pore; other site
395961004614	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
395961004615	Hexamer interface [polypeptide binding]; other site
395961004616	Hexagonal pore residue; other site
395961004617	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961004618	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004619	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004620	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004621	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004622	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961004623	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395961004624	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
395961004625	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
395961004626	active site
395961004627	catalytic residues [active]
395961004628	DNA binding site [nucleotide binding]
395961004629	Int/Topo IB signature motif; other site
395961004630	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395961004631	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961004632	putative active site [active]
395961004633	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
395961004634	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
395961004635	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
395961004636	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961004637	ATP binding site [chemical binding]; other site
395961004638	putative Mg++ binding site [ion binding]; other site
395961004639	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961004640	nucleotide binding region [chemical binding]; other site
395961004641	ATP-binding site [chemical binding]; other site
395961004642	PIN domain; Region: PIN_3; cl17397
395961004643	MoxR-like ATPases [General function prediction only]; Region: COG0714
395961004644	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961004645	Walker A motif; other site
395961004646	ATP binding site [chemical binding]; other site
395961004647	Walker B motif; other site
395961004648	arginine finger; other site
395961004649	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
395961004650	Protein of unknown function DUF58; Region: DUF58; pfam01882
395961004651	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
395961004652	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
395961004653	G1 box; other site
395961004654	putative GEF interaction site [polypeptide binding]; other site
395961004655	GTP/Mg2+ binding site [chemical binding]; other site
395961004656	Switch I region; other site
395961004657	G2 box; other site
395961004658	G3 box; other site
395961004659	Switch II region; other site
395961004660	G4 box; other site
395961004661	G5 box; other site
395961004662	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
395961004663	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
395961004664	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
395961004665	DNA methylase; Region: N6_N4_Mtase; cl17433
395961004666	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961004667	putative active site [active]
395961004668	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
395961004669	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395961004670	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961004671	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961004672	active site
395961004673	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
395961004674	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395961004675	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
395961004676	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
395961004677	Walker A/P-loop; other site
395961004678	ATP binding site [chemical binding]; other site
395961004679	Q-loop/lid; other site
395961004680	ABC transporter signature motif; other site
395961004681	Walker B; other site
395961004682	D-loop; other site
395961004683	H-loop/switch region; other site
395961004684	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
395961004685	putative carbohydrate binding site [chemical binding]; other site
395961004686	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
395961004687	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395961004688	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961004689	active site
395961004690	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
395961004691	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
395961004692	putative active site [active]
395961004693	putative metal binding site [ion binding]; other site
395961004694	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961004695	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961004696	active site
395961004697	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961004698	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961004699	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
395961004700	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
395961004701	putative active site [active]
395961004702	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961004703	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961004704	active site
395961004705	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395961004706	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961004707	active site
395961004708	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
395961004709	rod shape-determining protein MreC; Provisional; Region: PRK13922
395961004710	rod shape-determining protein MreC; Region: MreC; pfam04085
395961004711	rod shape-determining protein MreB; Provisional; Region: PRK13927
395961004712	MreB and similar proteins; Region: MreB_like; cd10225
395961004713	nucleotide binding site [chemical binding]; other site
395961004714	Mg binding site [ion binding]; other site
395961004715	putative protofilament interaction site [polypeptide binding]; other site
395961004716	RodZ interaction site [polypeptide binding]; other site
395961004717	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
395961004718	oligomer interface [polypeptide binding]; other site
395961004719	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
395961004720	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961004721	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961004722	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
395961004723	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961004724	motif II; other site
395961004725	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
395961004726	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
395961004727	putative NAD(P) binding site [chemical binding]; other site
395961004728	putative active site [active]
395961004729	photosystem I subunit VII; Region: psaC; CHL00065
395961004730	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
395961004731	TrkA-N domain; Region: TrkA_N; pfam02254
395961004732	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
395961004733	TrkA-C domain; Region: TrkA_C; pfam02080
395961004734	Ion channel; Region: Ion_trans_2; pfam07885
395961004735	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
395961004736	TrkA-N domain; Region: TrkA_N; pfam02254
395961004737	TrkA-C domain; Region: TrkA_C; pfam02080
395961004738	Response regulator receiver domain; Region: Response_reg; pfam00072
395961004739	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961004740	active site
395961004741	phosphorylation site [posttranslational modification]
395961004742	intermolecular recognition site; other site
395961004743	dimerization interface [polypeptide binding]; other site
395961004744	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
395961004745	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
395961004746	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
395961004747	dimer interface [polypeptide binding]; other site
395961004748	[2Fe-2S] cluster binding site [ion binding]; other site
395961004749	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961004750	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395961004751	Coenzyme A binding pocket [chemical binding]; other site
395961004752	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
395961004753	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
395961004754	putative ADP-binding pocket [chemical binding]; other site
395961004755	sucrose synthase; Region: sucr_synth; TIGR02470
395961004756	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
395961004757	putative ADP-binding pocket [chemical binding]; other site
395961004758	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961004759	bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896
395961004760	ligand binding site [chemical binding]; other site
395961004761	flexible hinge region; other site
395961004762	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961004763	ligand binding site [chemical binding]; other site
395961004764	flexible hinge region; other site
395961004765	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
395961004766	HlyD family secretion protein; Region: HlyD_3; pfam13437
395961004767	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961004768	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961004769	TIGR03032 family protein; Region: TIGR03032
395961004770	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
395961004771	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961004772	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961004773	active site
395961004774	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961004775	binding surface
395961004776	TPR motif; other site
395961004777	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395961004778	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961004779	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
395961004780	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961004781	FeS/SAM binding site; other site
395961004782	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
395961004783	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
395961004784	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
395961004785	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
395961004786	putative active site [active]
395961004787	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961004788	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961004789	Walker A/P-loop; other site
395961004790	ATP binding site [chemical binding]; other site
395961004791	Q-loop/lid; other site
395961004792	ABC transporter signature motif; other site
395961004793	Walker B; other site
395961004794	D-loop; other site
395961004795	H-loop/switch region; other site
395961004796	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
395961004797	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961004798	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961004799	Walker A/P-loop; other site
395961004800	ATP binding site [chemical binding]; other site
395961004801	Q-loop/lid; other site
395961004802	ABC transporter signature motif; other site
395961004803	Walker B; other site
395961004804	D-loop; other site
395961004805	H-loop/switch region; other site
395961004806	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
395961004807	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
395961004808	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
395961004809	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961004810	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961004811	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
395961004812	Winged helix-turn helix; Region: HTH_29; pfam13551
395961004813	Homeodomain-like domain; Region: HTH_32; pfam13565
395961004814	hypothetical protein; Validated; Region: PRK07411
395961004815	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
395961004816	ATP binding site [chemical binding]; other site
395961004817	substrate interface [chemical binding]; other site
395961004818	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
395961004819	active site residue [active]
395961004820	photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704
395961004821	photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877
395961004822	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
395961004823	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
395961004824	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
395961004825	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
395961004826	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
395961004827	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
395961004828	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
395961004829	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
395961004830	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
395961004831	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395961004832	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395961004833	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395961004834	protein binding site [polypeptide binding]; other site
395961004835	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
395961004836	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395961004837	hypothetical protein; Reviewed; Region: PRK00024
395961004838	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
395961004839	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
395961004840	MPN+ (JAMM) motif; other site
395961004841	Zinc-binding site [ion binding]; other site
395961004842	calcium/proton exchanger (cax); Region: cax; TIGR00378
395961004843	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
395961004844	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
395961004845	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961004846	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
395961004847	Transposase [DNA replication, recombination, and repair]; Region: COG5433
395961004848	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395961004849	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
395961004850	NAD(P) binding site [chemical binding]; other site
395961004851	homotetramer interface [polypeptide binding]; other site
395961004852	homodimer interface [polypeptide binding]; other site
395961004853	active site
395961004854	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
395961004855	hydroxyglutarate oxidase; Provisional; Region: PRK11728
395961004856	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
395961004857	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
395961004858	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
395961004859	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
395961004860	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
395961004861	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
395961004862	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395961004863	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
395961004864	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395961004865	DNA binding residues [nucleotide binding]
395961004866	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395961004867	metal binding site 2 [ion binding]; metal-binding site
395961004868	putative DNA binding helix; other site
395961004869	metal binding site 1 [ion binding]; metal-binding site
395961004870	dimer interface [polypeptide binding]; other site
395961004871	structural Zn2+ binding site [ion binding]; other site
395961004872	light-harvesting-like protein 3; Provisional; Region: PLN00014
395961004873	Hemerythrin-like domain; Region: Hr-like; cd12108
395961004874	Fe binding site [ion binding]; other site
395961004875	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
395961004876	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961004877	Coenzyme A binding pocket [chemical binding]; other site
395961004878	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961004879	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961004880	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395961004881	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004882	putative active site [active]
395961004883	heme pocket [chemical binding]; other site
395961004884	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
395961004885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961004886	ATP binding site [chemical binding]; other site
395961004887	Mg2+ binding site [ion binding]; other site
395961004888	G-X-G motif; other site
395961004889	PAS domain; Region: PAS_9; pfam13426
395961004890	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004891	putative active site [active]
395961004892	heme pocket [chemical binding]; other site
395961004893	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004894	PAS fold; Region: PAS_3; pfam08447
395961004895	putative active site [active]
395961004896	heme pocket [chemical binding]; other site
395961004897	PAS fold; Region: PAS_4; pfam08448
395961004898	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004899	putative active site [active]
395961004900	heme pocket [chemical binding]; other site
395961004901	PAS fold; Region: PAS_4; pfam08448
395961004902	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004903	putative active site [active]
395961004904	heme pocket [chemical binding]; other site
395961004905	PAS fold; Region: PAS_4; pfam08448
395961004906	PAS domain S-box; Region: sensory_box; TIGR00229
395961004907	PAS domain; Region: PAS_8; pfam13188
395961004908	PAS fold; Region: PAS_3; pfam08447
395961004909	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004910	putative active site [active]
395961004911	heme pocket [chemical binding]; other site
395961004912	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961004913	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961004914	dimer interface [polypeptide binding]; other site
395961004915	phosphorylation site [posttranslational modification]
395961004916	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961004917	ATP binding site [chemical binding]; other site
395961004918	Mg2+ binding site [ion binding]; other site
395961004919	G-X-G motif; other site
395961004920	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961004921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961004922	active site
395961004923	phosphorylation site [posttranslational modification]
395961004924	intermolecular recognition site; other site
395961004925	dimerization interface [polypeptide binding]; other site
395961004926	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961004927	GAF domain; Region: GAF; pfam01590
395961004928	GAF domain; Region: GAF; pfam01590
395961004929	PAS fold; Region: PAS_4; pfam08448
395961004930	PAS domain S-box; Region: sensory_box; TIGR00229
395961004931	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004932	putative active site [active]
395961004933	heme pocket [chemical binding]; other site
395961004934	PAS fold; Region: PAS_3; pfam08447
395961004935	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
395961004936	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961004937	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004938	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961004939	putative active site [active]
395961004940	heme pocket [chemical binding]; other site
395961004941	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961004942	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004943	putative active site [active]
395961004944	heme pocket [chemical binding]; other site
395961004945	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004946	putative active site [active]
395961004947	heme pocket [chemical binding]; other site
395961004948	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004949	PAS fold; Region: PAS_3; pfam08447
395961004950	putative active site [active]
395961004951	heme pocket [chemical binding]; other site
395961004952	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961004953	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961004954	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961004955	dimer interface [polypeptide binding]; other site
395961004956	phosphorylation site [posttranslational modification]
395961004957	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961004958	ATP binding site [chemical binding]; other site
395961004959	Mg2+ binding site [ion binding]; other site
395961004960	G-X-G motif; other site
395961004961	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961004962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961004963	active site
395961004964	phosphorylation site [posttranslational modification]
395961004965	intermolecular recognition site; other site
395961004966	dimerization interface [polypeptide binding]; other site
395961004967	PAS domain S-box; Region: sensory_box; TIGR00229
395961004968	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004969	putative active site [active]
395961004970	heme pocket [chemical binding]; other site
395961004971	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961004972	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004973	putative active site [active]
395961004974	heme pocket [chemical binding]; other site
395961004975	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004976	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961004977	putative active site [active]
395961004978	heme pocket [chemical binding]; other site
395961004979	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004980	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961004981	putative active site [active]
395961004982	heme pocket [chemical binding]; other site
395961004983	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961004984	putative active site [active]
395961004985	heme pocket [chemical binding]; other site
395961004986	GAF domain; Region: GAF; pfam01590
395961004987	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961004988	GAF domain; Region: GAF; pfam01590
395961004989	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961004990	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961004991	dimer interface [polypeptide binding]; other site
395961004992	phosphorylation site [posttranslational modification]
395961004993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961004994	ATP binding site [chemical binding]; other site
395961004995	Mg2+ binding site [ion binding]; other site
395961004996	G-X-G motif; other site
395961004997	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961004998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961004999	active site
395961005000	phosphorylation site [posttranslational modification]
395961005001	intermolecular recognition site; other site
395961005002	dimerization interface [polypeptide binding]; other site
395961005003	PAS domain; Region: PAS_9; pfam13426
395961005004	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
395961005005	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961005006	PAS fold; Region: PAS_3; pfam08447
395961005007	putative active site [active]
395961005008	heme pocket [chemical binding]; other site
395961005009	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961005010	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961005011	putative active site [active]
395961005012	heme pocket [chemical binding]; other site
395961005013	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961005014	putative active site [active]
395961005015	heme pocket [chemical binding]; other site
395961005016	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961005017	PAS fold; Region: PAS_3; pfam08447
395961005018	putative active site [active]
395961005019	heme pocket [chemical binding]; other site
395961005020	PAS fold; Region: PAS_3; pfam08447
395961005021	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961005022	putative active site [active]
395961005023	heme pocket [chemical binding]; other site
395961005024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961005025	PAS fold; Region: PAS_3; pfam08447
395961005026	putative active site [active]
395961005027	heme pocket [chemical binding]; other site
395961005028	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961005029	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961005030	dimer interface [polypeptide binding]; other site
395961005031	phosphorylation site [posttranslational modification]
395961005032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961005033	ATP binding site [chemical binding]; other site
395961005034	Mg2+ binding site [ion binding]; other site
395961005035	G-X-G motif; other site
395961005036	Response regulator receiver domain; Region: Response_reg; pfam00072
395961005037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961005038	active site
395961005039	phosphorylation site [posttranslational modification]
395961005040	intermolecular recognition site; other site
395961005041	dimerization interface [polypeptide binding]; other site
395961005042	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961005043	non-specific DNA binding site [nucleotide binding]; other site
395961005044	salt bridge; other site
395961005045	sequence-specific DNA binding site [nucleotide binding]; other site
395961005046	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
395961005047	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395961005048	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
395961005049	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395961005050	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395961005051	Uncharacterized conserved protein [Function unknown]; Region: COG2361
395961005052	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395961005053	active site
395961005054	NTP binding site [chemical binding]; other site
395961005055	metal binding triad [ion binding]; metal-binding site
395961005056	antibiotic binding site [chemical binding]; other site
395961005057	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961005058	non-specific DNA binding site [nucleotide binding]; other site
395961005059	salt bridge; other site
395961005060	sequence-specific DNA binding site [nucleotide binding]; other site
395961005061	Domain of unknown function (DUF955); Region: DUF955; pfam06114
395961005062	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
395961005063	glucose-1-dehydrogenase; Provisional; Region: PRK08936
395961005064	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
395961005065	NAD binding site [chemical binding]; other site
395961005066	homodimer interface [polypeptide binding]; other site
395961005067	active site
395961005068	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
395961005069	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
395961005070	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395961005071	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395961005072	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395961005073	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
395961005074	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
395961005075	nucleoside/Zn binding site; other site
395961005076	dimer interface [polypeptide binding]; other site
395961005077	catalytic motif [active]
395961005078	Uncharacterized conserved protein [Function unknown]; Region: COG5464
395961005079	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961005080	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395961005081	active site
395961005082	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
395961005083	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
395961005084	hypothetical protein; Provisional; Region: PRK11770
395961005085	Domain of unknown function (DUF307); Region: DUF307; pfam03733
395961005086	Domain of unknown function (DUF307); Region: DUF307; pfam03733
395961005087	DNA primase; Validated; Region: dnaG; PRK05667
395961005088	CHC2 zinc finger; Region: zf-CHC2; pfam01807
395961005089	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
395961005090	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
395961005091	active site
395961005092	metal binding site [ion binding]; metal-binding site
395961005093	interdomain interaction site; other site
395961005094	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
395961005095	Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529
395961005096	Bacterial SH3 domain; Region: SH3_3; pfam08239
395961005097	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
395961005098	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
395961005099	active site
395961005100	metal binding site [ion binding]; metal-binding site
395961005101	SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049
395961005102	reactive center loop; other site
395961005103	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
395961005104	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
395961005105	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961005106	ATP binding site [chemical binding]; other site
395961005107	putative Mg++ binding site [ion binding]; other site
395961005108	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961005109	nucleotide binding region [chemical binding]; other site
395961005110	ATP-binding site [chemical binding]; other site
395961005111	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
395961005112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
395961005113	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
395961005114	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
395961005115	Acyltransferase family; Region: Acyl_transf_3; pfam01757
395961005116	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395961005117	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
395961005118	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
395961005119	putative homodimer interface [polypeptide binding]; other site
395961005120	putative active site pocket [active]
395961005121	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
395961005122	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
395961005123	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
395961005124	active site
395961005125	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
395961005126	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
395961005127	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
395961005128	Phycobilisome protein; Region: Phycobilisome; cl08227
395961005129	glutamine synthetase, type I; Region: GlnA; TIGR00653
395961005130	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
395961005131	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395961005132	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
395961005133	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
395961005134	iron-sulfur cluster [ion binding]; other site
395961005135	[2Fe-2S] cluster binding site [ion binding]; other site
395961005136	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961005137	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
395961005138	active site
395961005139	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
395961005140	FAD dependent oxidoreductase; Region: DAO; pfam01266
395961005141	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
395961005142	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
395961005143	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
395961005144	HflK protein; Region: hflK; TIGR01933
395961005145	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
395961005146	argininosuccinate synthase; Provisional; Region: PRK13820
395961005147	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
395961005148	ANP binding site [chemical binding]; other site
395961005149	Substrate Binding Site II [chemical binding]; other site
395961005150	Substrate Binding Site I [chemical binding]; other site
395961005151	putative phosphoketolase; Provisional; Region: PRK05261
395961005152	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
395961005153	TPP-binding site; other site
395961005154	XFP C-terminal domain; Region: XFP_C; pfam09363
395961005155	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
395961005156	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
395961005157	domain interfaces; other site
395961005158	active site
395961005159	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
395961005160	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
395961005161	putative active site [active]
395961005162	FtsH Extracellular; Region: FtsH_ext; pfam06480
395961005163	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
395961005164	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961005165	Walker A motif; other site
395961005166	ATP binding site [chemical binding]; other site
395961005167	Walker B motif; other site
395961005168	arginine finger; other site
395961005169	Peptidase family M41; Region: Peptidase_M41; pfam01434
395961005170	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395961005171	HSP70 interaction site [polypeptide binding]; other site
395961005172	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961005173	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961005174	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
395961005175	Sporulation and spore germination; Region: Germane; pfam10646
395961005176	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
395961005177	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395961005178	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
395961005179	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
395961005180	Predicted membrane protein [Function unknown]; Region: COG3431
395961005181	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
395961005182	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395961005183	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
395961005184	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
395961005185	MgtC family; Region: MgtC; pfam02308
395961005186	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273
395961005187	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395961005188	putative NAD(P) binding site [chemical binding]; other site
395961005189	phosphoribosylformylglycinamidine cyclo-ligase; Region: PLN02557
395961005190	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
395961005191	FAD binding domain; Region: FAD_binding_4; pfam01565
395961005192	Berberine and berberine like; Region: BBE; pfam08031
395961005193	OsmC-like protein; Region: OsmC; pfam02566
395961005194	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
395961005195	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
395961005196	Sulfate transporter family; Region: Sulfate_transp; pfam00916
395961005197	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
395961005198	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
395961005199	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
395961005200	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
395961005201	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
395961005202	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
395961005203	Ligand Binding Site [chemical binding]; other site
395961005204	HAS barrel domain; Region: HAS-barrel; pfam09378
395961005205	Domain of unknown function DUF87; Region: DUF87; pfam01935
395961005206	AAA-like domain; Region: AAA_10; pfam12846
395961005207	tyramine oxidase; Provisional; Region: tynA; PRK11504
395961005208	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
395961005209	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
395961005210	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
395961005211	DNA methylase; Region: N6_N4_Mtase; cl17433
395961005212	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
395961005213	putative active site [active]
395961005214	Zn binding site [ion binding]; other site
395961005215	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
395961005216	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961005217	Coenzyme A binding pocket [chemical binding]; other site
395961005218	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
395961005219	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395961005220	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395961005221	PRC-barrel domain; Region: PRC; pfam05239
395961005222	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
395961005223	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
395961005224	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
395961005225	Protein of unknown function (DUF512); Region: DUF512; pfam04459
395961005226	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
395961005227	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
395961005228	active site
395961005229	catalytic site [active]
395961005230	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
395961005231	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
395961005232	amidase catalytic site [active]
395961005233	Zn binding residues [ion binding]; other site
395961005234	substrate binding site [chemical binding]; other site
395961005235	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
395961005236	active site
395961005237	SAM binding site [chemical binding]; other site
395961005238	homodimer interface [polypeptide binding]; other site
395961005239	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
395961005240	Peptidase family M23; Region: Peptidase_M23; pfam01551
395961005241	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395961005242	17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs; Region: 17beta-HSD1_like_SDR_c; cd05356
395961005243	putative NAD(P) binding site [chemical binding]; other site
395961005244	active site
395961005245	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
395961005246	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
395961005247	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961005248	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395961005249	putative active site [active]
395961005250	heme pocket [chemical binding]; other site
395961005251	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961005252	dimer interface [polypeptide binding]; other site
395961005253	phosphorylation site [posttranslational modification]
395961005254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961005255	ATP binding site [chemical binding]; other site
395961005256	Mg2+ binding site [ion binding]; other site
395961005257	G-X-G motif; other site
395961005258	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961005259	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961005260	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961005261	Phosphotransferase enzyme family; Region: APH; pfam01636
395961005262	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
395961005263	active site
395961005264	substrate binding site [chemical binding]; other site
395961005265	ATP binding site [chemical binding]; other site
395961005266	CP12 domain; Region: CP12; pfam02672
395961005267	B12 binding domain; Region: B12-binding; pfam02310
395961005268	B12 binding site [chemical binding]; other site
395961005269	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
395961005270	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961005271	FeS/SAM binding site; other site
395961005272	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
395961005273	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395961005274	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
395961005275	active site
395961005276	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
395961005277	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
395961005278	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961005279	FeS/SAM binding site; other site
395961005280	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961005281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961005282	S-adenosylmethionine binding site [chemical binding]; other site
395961005283	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
395961005284	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
395961005285	putative NADP binding site [chemical binding]; other site
395961005286	putative substrate binding site [chemical binding]; other site
395961005287	active site
395961005288	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395961005289	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961005290	short chain dehydrogenase; Provisional; Region: PRK06181
395961005291	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961005292	NAD(P) binding site [chemical binding]; other site
395961005293	active site
395961005294	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395961005295	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961005296	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395961005297	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
395961005298	putative C-terminal domain interface [polypeptide binding]; other site
395961005299	putative GSH binding site (G-site) [chemical binding]; other site
395961005300	putative dimer interface [polypeptide binding]; other site
395961005301	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
395961005302	putative N-terminal domain interface [polypeptide binding]; other site
395961005303	putative dimer interface [polypeptide binding]; other site
395961005304	putative substrate binding pocket (H-site) [chemical binding]; other site
395961005305	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
395961005306	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
395961005307	Transcriptional activator [Transcription]; Region: ChrR; COG3806
395961005308	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
395961005309	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
395961005310	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
395961005311	SnoaL-like domain; Region: SnoaL_2; pfam12680
395961005312	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395961005313	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
395961005314	structural tetrad; other site
395961005315	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395961005316	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
395961005317	P-loop, Walker A motif; other site
395961005318	Base recognition motif; other site
395961005319	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395961005320	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
395961005321	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
395961005322	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
395961005323	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395961005324	putative PBP binding regions; other site
395961005325	ABC-ATPase subunit  interface; other site
395961005326	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
395961005327	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
395961005328	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
395961005329	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
395961005330	metal binding site [ion binding]; metal-binding site
395961005331	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395961005332	metal binding site 2 [ion binding]; metal-binding site
395961005333	putative DNA binding helix; other site
395961005334	metal binding site 1 [ion binding]; metal-binding site
395961005335	dimer interface [polypeptide binding]; other site
395961005336	structural Zn2+ binding site [ion binding]; other site
395961005337	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
395961005338	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
395961005339	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
395961005340	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395961005341	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961005342	motif II; other site
395961005343	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
395961005344	Ferritin-like domain; Region: Ferritin; pfam00210
395961005345	ferroxidase diiron center [ion binding]; other site
395961005346	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
395961005347	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
395961005348	Isochorismatase family; Region: Isochorismatase; pfam00857
395961005349	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
395961005350	catalytic triad [active]
395961005351	conserved cis-peptide bond; other site
395961005352	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
395961005353	Isochorismatase family; Region: Isochorismatase; pfam00857
395961005354	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
395961005355	catalytic triad [active]
395961005356	dimer interface [polypeptide binding]; other site
395961005357	conserved cis-peptide bond; other site
395961005358	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
395961005359	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
395961005360	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961005361	GAF domain; Region: GAF_3; pfam13492
395961005362	GAF domain; Region: GAF_2; pfam13185
395961005363	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
395961005364	Histidine kinase; Region: HisKA_3; pfam07730
395961005365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961005366	ATP binding site [chemical binding]; other site
395961005367	Mg2+ binding site [ion binding]; other site
395961005368	G-X-G motif; other site
395961005369	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395961005370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961005371	active site
395961005372	phosphorylation site [posttranslational modification]
395961005373	intermolecular recognition site; other site
395961005374	dimerization interface [polypeptide binding]; other site
395961005375	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395961005376	DNA binding residues [nucleotide binding]
395961005377	dimerization interface [polypeptide binding]; other site
395961005378	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
395961005379	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
395961005380	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395961005381	active site
395961005382	NTP binding site [chemical binding]; other site
395961005383	metal binding triad [ion binding]; metal-binding site
395961005384	antibiotic binding site [chemical binding]; other site
395961005385	Uncharacterized conserved protein [Function unknown]; Region: COG2361
395961005386	C factor cell-cell signaling protein; Provisional; Region: PRK09009
395961005387	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
395961005388	NADP binding site [chemical binding]; other site
395961005389	homodimer interface [polypeptide binding]; other site
395961005390	active site
395961005391	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395961005392	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
395961005393	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
395961005394	active site
395961005395	FHA domain; Region: FHA; pfam00498
395961005396	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
395961005397	dimerization interface [polypeptide binding]; other site
395961005398	active site
395961005399	metal binding site [ion binding]; metal-binding site
395961005400	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
395961005401	anti sigma factor interaction site; other site
395961005402	regulatory phosphorylation site [posttranslational modification]; other site
395961005403	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
395961005404	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
395961005405	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
395961005406	catalytic site [active]
395961005407	subunit interface [polypeptide binding]; other site
395961005408	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
395961005409	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
395961005410	Ligand binding site; other site
395961005411	Putative Catalytic site; other site
395961005412	DXD motif; other site
395961005413	Uncharacterized conserved protein [Function unknown]; Region: COG0398
395961005414	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
395961005415	Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051
395961005416	Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051
395961005417	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
395961005418	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
395961005419	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
395961005420	Walker A/P-loop; other site
395961005421	ATP binding site [chemical binding]; other site
395961005422	Q-loop/lid; other site
395961005423	ABC transporter signature motif; other site
395961005424	Walker B; other site
395961005425	D-loop; other site
395961005426	H-loop/switch region; other site
395961005427	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961005428	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961005429	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961005430	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
395961005431	active site
395961005432	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395961005433	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961005434	active site
395961005435	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961005436	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961005437	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961005438	active site
395961005439	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395961005440	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961005441	active site
395961005442	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961005443	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961005444	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961005445	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961005446	active site
395961005447	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395961005448	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961005449	active site
395961005450	glycogen synthase; Provisional; Region: glgA; PRK00654
395961005451	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
395961005452	ADP-binding pocket [chemical binding]; other site
395961005453	homodimer interface [polypeptide binding]; other site
395961005454	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
395961005455	short chain dehydrogenase; Provisional; Region: PRK06057
395961005456	classical (c) SDRs; Region: SDR_c; cd05233
395961005457	NAD(P) binding site [chemical binding]; other site
395961005458	active site
395961005459	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
395961005460	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
395961005461	catalytic triad [active]
395961005462	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
395961005463	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395961005464	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
395961005465	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395961005466	NAD(P) binding site [chemical binding]; other site
395961005467	catalytic residues [active]
395961005468	ethanolamine permease; Region: 2A0305; TIGR00908
395961005469	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
395961005470	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
395961005471	glutaminase A; Region: Gln_ase; TIGR03814
395961005472	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
395961005473	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395961005474	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395961005475	Uncharacterized conserved protein [Function unknown]; Region: COG2135
395961005476	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
395961005477	mercuric reductase; Validated; Region: PRK06370
395961005478	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395961005479	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395961005480	polyphosphate kinase; Provisional; Region: PRK05443
395961005481	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
395961005482	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
395961005483	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
395961005484	putative domain interface [polypeptide binding]; other site
395961005485	putative active site [active]
395961005486	catalytic site [active]
395961005487	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
395961005488	putative domain interface [polypeptide binding]; other site
395961005489	putative active site [active]
395961005490	catalytic site [active]
395961005491	CHAD domain; Region: CHAD; cl10506
395961005492	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
395961005493	nitrilase; Region: PLN02798
395961005494	putative active site [active]
395961005495	catalytic triad [active]
395961005496	dimer interface [polypeptide binding]; other site
395961005497	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
395961005498	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
395961005499	putative active site [active]
395961005500	putative dimer interface [polypeptide binding]; other site
395961005501	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
395961005502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
395961005503	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
395961005504	dimer interface [polypeptide binding]; other site
395961005505	catalytic triad [active]
395961005506	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395961005507	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395961005508	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
395961005509	active site
395961005510	dimer interface [polypeptide binding]; other site
395961005511	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
395961005512	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
395961005513	active site
395961005514	catalytic triad [active]
395961005515	oxyanion hole [active]
395961005516	CopC domain; Region: CopC; cl01012
395961005517	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
395961005518	Protein export membrane protein; Region: SecD_SecF; cl14618
395961005519	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395961005520	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395961005521	HlyD family secretion protein; Region: HlyD_3; pfam13437
395961005522	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
395961005523	metal-binding site [ion binding]
395961005524	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395961005525	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
395961005526	metal-binding site [ion binding]
395961005527	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395961005528	Soluble P-type ATPase [General function prediction only]; Region: COG4087
395961005529	Plastocyanin domain containing protein [General function prediction only]; Region: COG4633
395961005530	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
395961005531	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
395961005532	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
395961005533	substrate binding site [chemical binding]; other site
395961005534	hexamer interface [polypeptide binding]; other site
395961005535	metal binding site [ion binding]; metal-binding site
395961005536	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961005537	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961005538	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
395961005539	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
395961005540	putative NAD(P) binding site [chemical binding]; other site
395961005541	active site
395961005542	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961005543	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961005544	S-adenosylmethionine binding site [chemical binding]; other site
395961005545	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395961005546	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
395961005547	putative NAD(P) binding site [chemical binding]; other site
395961005548	HD domain; Region: HD_4; pfam13328
395961005549	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395961005550	extended (e) SDRs; Region: SDR_e; cd08946
395961005551	NAD(P) binding site [chemical binding]; other site
395961005552	active site
395961005553	substrate binding site [chemical binding]; other site
395961005554	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
395961005555	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961005556	active site
395961005557	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
395961005558	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
395961005559	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
395961005560	putative dimer interface [polypeptide binding]; other site
395961005561	N-terminal domain interface [polypeptide binding]; other site
395961005562	putative substrate binding pocket (H-site) [chemical binding]; other site
395961005563	heat shock protein 90; Provisional; Region: PRK05218
395961005564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961005565	ATP binding site [chemical binding]; other site
395961005566	Mg2+ binding site [ion binding]; other site
395961005567	G-X-G motif; other site
395961005568	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
395961005569	PLD-like domain; Region: PLDc_2; pfam13091
395961005570	putative active site [active]
395961005571	catalytic site [active]
395961005572	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
395961005573	PLD-like domain; Region: PLDc_2; pfam13091
395961005574	putative active site [active]
395961005575	catalytic site [active]
395961005576	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
395961005577	Helix-hairpin-helix motif; Region: HHH; pfam00633
395961005578	putative phosphoketolase; Provisional; Region: PRK05261
395961005579	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
395961005580	TPP-binding site; other site
395961005581	XFP C-terminal domain; Region: XFP_C; pfam09363
395961005582	phosphoenolpyruvate synthase; Validated; Region: PRK06464
395961005583	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
395961005584	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
395961005585	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
395961005586	Divergent AAA domain; Region: AAA_4; pfam04326
395961005587	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961005588	TPR motif; other site
395961005589	TPR repeat; Region: TPR_11; pfam13414
395961005590	binding surface
395961005591	TPR repeat; Region: TPR_11; pfam13414
395961005592	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961005593	binding surface
395961005594	TPR motif; other site
395961005595	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961005596	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961005597	XisI protein; Region: XisI; pfam08869
395961005598	XisH protein; Region: XisH; pfam08814
395961005599	Ion channel; Region: Ion_trans_2; pfam07885
395961005600	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
395961005601	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
395961005602	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
395961005603	NADP binding site [chemical binding]; other site
395961005604	active site
395961005605	putative substrate binding site [chemical binding]; other site
395961005606	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
395961005607	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961005608	putative homodimer interface [polypeptide binding]; other site
395961005609	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
395961005610	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961005611	UDP-galactopyranose mutase; Region: GLF; pfam03275
395961005612	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
395961005613	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
395961005614	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
395961005615	Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991
395961005616	active site
395961005617	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
395961005618	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
395961005619	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961005620	Walker A motif; other site
395961005621	ATP binding site [chemical binding]; other site
395961005622	Walker B motif; other site
395961005623	arginine finger; other site
395961005624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961005625	Walker A motif; other site
395961005626	ATP binding site [chemical binding]; other site
395961005627	Walker B motif; other site
395961005628	arginine finger; other site
395961005629	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
395961005630	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395961005631	RNA binding surface [nucleotide binding]; other site
395961005632	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
395961005633	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395961005634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961005635	active site
395961005636	phosphorylation site [posttranslational modification]
395961005637	intermolecular recognition site; other site
395961005638	dimerization interface [polypeptide binding]; other site
395961005639	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395961005640	DNA binding site [nucleotide binding]
395961005641	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
395961005642	active site
395961005643	intersubunit interface [polypeptide binding]; other site
395961005644	catalytic residue [active]
395961005645	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
395961005646	intersubunit interface [polypeptide binding]; other site
395961005647	active site
395961005648	zinc binding site [ion binding]; other site
395961005649	Na+ binding site [ion binding]; other site
395961005650	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
395961005651	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
395961005652	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
395961005653	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
395961005654	homodimer interface [polypeptide binding]; other site
395961005655	metal binding site [ion binding]; metal-binding site
395961005656	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
395961005657	homodimer interface [polypeptide binding]; other site
395961005658	active site
395961005659	putative chemical substrate binding site [chemical binding]; other site
395961005660	metal binding site [ion binding]; metal-binding site
395961005661	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
395961005662	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
395961005663	homodimer interface [polypeptide binding]; other site
395961005664	substrate-cofactor binding pocket; other site
395961005665	catalytic residue [active]
395961005666	NifU-like domain; Region: NifU; pfam01106
395961005667	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
395961005668	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
395961005669	lipoyl attachment site [posttranslational modification]; other site
395961005670	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
395961005671	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395961005672	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
395961005673	aromatic arch; other site
395961005674	DCoH dimer interaction site [polypeptide binding]; other site
395961005675	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
395961005676	DCoH tetramer interaction site [polypeptide binding]; other site
395961005677	substrate binding site [chemical binding]; other site
395961005678	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
395961005679	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
395961005680	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395961005681	dimerization interface [polypeptide binding]; other site
395961005682	putative DNA binding site [nucleotide binding]; other site
395961005683	putative Zn2+ binding site [ion binding]; other site
395961005684	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
395961005685	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961005686	FeS/SAM binding site; other site
395961005687	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
395961005688	active site residue [active]
395961005689	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
395961005690	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961005691	FeS/SAM binding site; other site
395961005692	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395961005693	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
395961005694	lipoyl-biotinyl attachment site [posttranslational modification]; other site
395961005695	HlyD family secretion protein; Region: HlyD_3; pfam13437
395961005696	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395961005697	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
395961005698	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395961005699	GTPase CgtA; Reviewed; Region: obgE; PRK12299
395961005700	GTP1/OBG; Region: GTP1_OBG; pfam01018
395961005701	Obg GTPase; Region: Obg; cd01898
395961005702	G1 box; other site
395961005703	GTP/Mg2+ binding site [chemical binding]; other site
395961005704	Switch I region; other site
395961005705	G2 box; other site
395961005706	G3 box; other site
395961005707	Switch II region; other site
395961005708	G4 box; other site
395961005709	G5 box; other site
395961005710	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
395961005711	putative homodimer interface [polypeptide binding]; other site
395961005712	putative active site pocket [active]
395961005713	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
395961005714	Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958
395961005715	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
395961005716	HEAT-like repeat; Region: HEAT_EZ; pfam13513
395961005717	protein binding surface [polypeptide binding]; other site
395961005718	HEAT repeats; Region: HEAT_2; pfam13646
395961005719	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961005720	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961005721	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961005722	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
395961005723	dimer interface [polypeptide binding]; other site
395961005724	motif 1; other site
395961005725	active site
395961005726	motif 2; other site
395961005727	motif 3; other site
395961005728	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
395961005729	Leucine-rich repeats; other site
395961005730	Substrate binding site [chemical binding]; other site
395961005731	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
395961005732	Leucine rich repeat; Region: LRR_8; pfam13855
395961005733	Leucine rich repeat; Region: LRR_8; pfam13855
395961005734	Leucine rich repeat; Region: LRR_8; pfam13855
395961005735	Leucine rich repeat; Region: LRR_8; pfam13855
395961005736	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961005737	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961005738	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
395961005739	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
395961005740	Homeodomain-like domain; Region: HTH_23; pfam13384
395961005741	Winged helix-turn helix; Region: HTH_29; pfam13551
395961005742	Homeodomain-like domain; Region: HTH_32; pfam13565
395961005743	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961005744	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961005745	Uncharacterized small protein [Function unknown]; Region: COG2886
395961005746	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395961005747	motif 1; other site
395961005748	dimer interface [polypeptide binding]; other site
395961005749	hypothetical protein; Provisional; Region: PLN03150
395961005750	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
395961005751	Leucine-rich repeats; other site
395961005752	Leucine rich repeat; Region: LRR_8; pfam13855
395961005753	Substrate binding site [chemical binding]; other site
395961005754	Leucine rich repeat; Region: LRR_8; pfam13855
395961005755	Leucine rich repeat; Region: LRR_8; pfam13855
395961005756	Leucine rich repeat; Region: LRR_8; pfam13855
395961005757	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
395961005758	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
395961005759	Leucine-rich repeats; other site
395961005760	Substrate binding site [chemical binding]; other site
395961005761	Leucine rich repeat; Region: LRR_8; pfam13855
395961005762	Leucine rich repeat; Region: LRR_8; pfam13855
395961005763	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961005764	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961005765	S-adenosylmethionine binding site [chemical binding]; other site
395961005766	Uncharacterized conserved protein [Function unknown]; Region: COG2968
395961005767	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
395961005768	TPR repeat; Region: TPR_11; pfam13414
395961005769	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395961005770	TPR repeat; Region: TPR_11; pfam13414
395961005771	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961005772	binding surface
395961005773	TPR motif; other site
395961005774	TPR repeat; Region: TPR_11; pfam13414
395961005775	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
395961005776	isocitrate dehydrogenase; Validated; Region: PRK07362
395961005777	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
395961005778	NlpC/P60 family; Region: NLPC_P60; pfam00877
395961005779	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395961005780	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
395961005781	dihydropteroate synthase; Region: DHPS; TIGR01496
395961005782	substrate binding pocket [chemical binding]; other site
395961005783	dimer interface [polypeptide binding]; other site
395961005784	inhibitor binding site; inhibition site
395961005785	Response regulator receiver domain; Region: Response_reg; pfam00072
395961005786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961005787	active site
395961005788	phosphorylation site [posttranslational modification]
395961005789	intermolecular recognition site; other site
395961005790	dimerization interface [polypeptide binding]; other site
395961005791	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
395961005792	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
395961005793	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
395961005794	anti sigma factor interaction site; other site
395961005795	regulatory phosphorylation site [posttranslational modification]; other site
395961005796	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
395961005797	phosphatidate cytidylyltransferase; Region: PLN02953
395961005798	CpeS-like protein; Region: CpeS; pfam09367
395961005799	OstA-like protein; Region: OstA; cl00844
395961005800	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
395961005801	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
395961005802	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
395961005803	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
395961005804	Hexamer interface [polypeptide binding]; other site
395961005805	Hexagonal pore residue; other site
395961005806	ribosome maturation protein RimP; Reviewed; Region: PRK00092
395961005807	Sm and related proteins; Region: Sm_like; cl00259
395961005808	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
395961005809	putative oligomer interface [polypeptide binding]; other site
395961005810	putative RNA binding site [nucleotide binding]; other site
395961005811	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
395961005812	NusA N-terminal domain; Region: NusA_N; pfam08529
395961005813	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
395961005814	RNA binding site [nucleotide binding]; other site
395961005815	homodimer interface [polypeptide binding]; other site
395961005816	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
395961005817	G-X-X-G motif; other site
395961005818	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
395961005819	G-X-X-G motif; other site
395961005820	Protein of unknown function (DUF448); Region: DUF448; pfam04296
395961005821	putative RNA binding cleft [nucleotide binding]; other site
395961005822	translation initiation factor IF-2; Region: IF-2; TIGR00487
395961005823	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
395961005824	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
395961005825	G1 box; other site
395961005826	putative GEF interaction site [polypeptide binding]; other site
395961005827	GTP/Mg2+ binding site [chemical binding]; other site
395961005828	Switch I region; other site
395961005829	G2 box; other site
395961005830	G3 box; other site
395961005831	Switch II region; other site
395961005832	G4 box; other site
395961005833	G5 box; other site
395961005834	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
395961005835	Translation-initiation factor 2; Region: IF-2; pfam11987
395961005836	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
395961005837	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
395961005838	PAS fold; Region: PAS_4; pfam08448
395961005839	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961005840	GAF domain; Region: GAF; pfam01590
395961005841	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961005842	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961005843	dimer interface [polypeptide binding]; other site
395961005844	phosphorylation site [posttranslational modification]
395961005845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961005846	ATP binding site [chemical binding]; other site
395961005847	Mg2+ binding site [ion binding]; other site
395961005848	G-X-G motif; other site
395961005849	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961005850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961005851	active site
395961005852	phosphorylation site [posttranslational modification]
395961005853	intermolecular recognition site; other site
395961005854	dimerization interface [polypeptide binding]; other site
395961005855	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
395961005856	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
395961005857	active site
395961005858	catalytic residues [active]
395961005859	DNA binding site [nucleotide binding]
395961005860	Int/Topo IB signature motif; other site
395961005861	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
395961005862	active site
395961005863	metal binding site [ion binding]; metal-binding site
395961005864	Domain of unknown function (DUF927); Region: DUF927; pfam06048
395961005865	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
395961005866	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
395961005867	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961005868	ATP binding site [chemical binding]; other site
395961005869	putative Mg++ binding site [ion binding]; other site
395961005870	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
395961005871	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961005872	nucleotide binding region [chemical binding]; other site
395961005873	ATP-binding site [chemical binding]; other site
395961005874	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
395961005875	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
395961005876	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
395961005877	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
395961005878	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
395961005879	putative active site [active]
395961005880	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
395961005881	metal ion-dependent adhesion site (MIDAS); other site
395961005882	Protein phosphatase 2C; Region: PP2C_2; pfam13672
395961005883	active site
395961005884	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
395961005885	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
395961005886	substrate binding site [chemical binding]; other site
395961005887	activation loop (A-loop); other site
395961005888	transposase; Validated; Region: PRK08181
395961005889	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961005890	Walker A motif; other site
395961005891	ATP binding site [chemical binding]; other site
395961005892	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
395961005893	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
395961005894	intrachain domain interface; other site
395961005895	heme bL binding site [chemical binding]; other site
395961005896	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
395961005897	interchain domain interface [polypeptide binding]; other site
395961005898	heme bH binding site [chemical binding]; other site
395961005899	Qo binding site; other site
395961005900	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
395961005901	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395961005902	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
395961005903	nudix motif; other site
395961005904	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
395961005905	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395961005906	catalytic residues [active]
395961005907	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395961005908	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
395961005909	putative dimer interface [polypeptide binding]; other site
395961005910	UbiA prenyltransferase family; Region: UbiA; pfam01040
395961005911	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
395961005912	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395961005913	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
395961005914	CHAT domain; Region: CHAT; cl17868
395961005915	TPR repeat; Region: TPR_11; pfam13414
395961005916	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
395961005917	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
395961005918	putative ligand binding site [chemical binding]; other site
395961005919	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961005920	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961005921	active site
395961005922	ATP binding site [chemical binding]; other site
395961005923	substrate binding site [chemical binding]; other site
395961005924	activation loop (A-loop); other site
395961005925	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961005926	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395961005927	structural tetrad; other site
395961005928	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
395961005929	SPFH domain / Band 7 family; Region: Band_7; pfam01145
395961005930	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
395961005931	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
395961005932	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961005933	binding surface
395961005934	TPR motif; other site
395961005935	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395961005936	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961005937	binding surface
395961005938	TPR motif; other site
395961005939	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961005940	binding surface
395961005941	TPR motif; other site
395961005942	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961005943	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961005944	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961005945	radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261
395961005946	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961005947	FeS/SAM binding site; other site
395961005948	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
395961005949	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
395961005950	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395961005951	substrate binding pocket [chemical binding]; other site
395961005952	membrane-bound complex binding site; other site
395961005953	hinge residues; other site
395961005954	rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260
395961005955	Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607
395961005956	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
395961005957	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
395961005958	Helix-turn-helix domain; Region: HTH_18; pfam12833
395961005959	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395961005960	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961005961	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961005962	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961005963	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961005964	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961005965	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961005966	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
395961005967	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
395961005968	Hemerythrin-like domain; Region: Hr-like; cd12108
395961005969	Fe binding site [ion binding]; other site
395961005970	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
395961005971	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
395961005972	dimer interface [polypeptide binding]; other site
395961005973	active site
395961005974	AAA domain; Region: AAA_21; pfam13304
395961005975	RloB-like protein; Region: RloB; pfam13707
395961005976	Cache domain; Region: Cache_1; pfam02743
395961005977	HAMP domain; Region: HAMP; pfam00672
395961005978	dimerization interface [polypeptide binding]; other site
395961005979	PAS domain S-box; Region: sensory_box; TIGR00229
395961005980	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961005981	putative active site [active]
395961005982	heme pocket [chemical binding]; other site
395961005983	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961005984	PAS fold; Region: PAS_3; pfam08447
395961005985	putative active site [active]
395961005986	heme pocket [chemical binding]; other site
395961005987	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961005988	Histidine kinase; Region: HisKA_2; pfam07568
395961005989	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961005990	ATP binding site [chemical binding]; other site
395961005991	Mg2+ binding site [ion binding]; other site
395961005992	G-X-G motif; other site
395961005993	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
395961005994	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
395961005995	active site
395961005996	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
395961005997	galactokinase; Provisional; Region: PRK03817
395961005998	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
395961005999	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
395961006000	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
395961006001	Chain length determinant protein; Region: Wzz; cl15801
395961006002	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
395961006003	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395961006004	Magnesium ion binding site [ion binding]; other site
395961006005	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
395961006006	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
395961006007	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
395961006008	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
395961006009	substrate binding site; other site
395961006010	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
395961006011	extended (e) SDRs; Region: SDR_e; cd08946
395961006012	NAD(P) binding site [chemical binding]; other site
395961006013	active site
395961006014	substrate binding site [chemical binding]; other site
395961006015	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961006016	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
395961006017	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961006018	Methyltransferase domain; Region: Methyltransf_12; pfam08242
395961006019	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
395961006020	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961006021	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961006022	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
395961006023	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395961006024	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961006025	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395961006026	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
395961006027	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961006028	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961006029	active site
395961006030	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961006031	Methyltransferase domain; Region: Methyltransf_11; pfam08241
395961006032	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
395961006033	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
395961006034	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961006035	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395961006036	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961006037	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
395961006038	NAD(P) binding site [chemical binding]; other site
395961006039	active site
395961006040	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961006041	Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316
395961006042	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395961006043	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961006044	NAD(P) binding site [chemical binding]; other site
395961006045	active site
395961006046	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961006047	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
395961006048	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
395961006049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961006050	Walker A/P-loop; other site
395961006051	ATP binding site [chemical binding]; other site
395961006052	Q-loop/lid; other site
395961006053	ABC transporter signature motif; other site
395961006054	Walker B; other site
395961006055	D-loop; other site
395961006056	H-loop/switch region; other site
395961006057	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
395961006058	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
395961006059	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
395961006060	Ligand binding site; other site
395961006061	Putative Catalytic site; other site
395961006062	DXD motif; other site
395961006063	Uncharacterized conserved protein [Function unknown]; Region: COG0398
395961006064	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
395961006065	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
395961006066	Acyltransferase family; Region: Acyl_transf_3; pfam01757
395961006067	Acyltransferase family; Region: Acyl_transf_3; pfam01757
395961006068	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
395961006069	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961006070	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
395961006071	Transposase [DNA replication, recombination, and repair]; Region: COG5433
395961006072	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961006073	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
395961006074	putative ADP-binding pocket [chemical binding]; other site
395961006075	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961006076	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961006077	active site
395961006078	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
395961006079	extended (e) SDRs; Region: SDR_e; cd08946
395961006080	NAD(P) binding site [chemical binding]; other site
395961006081	active site
395961006082	substrate binding site [chemical binding]; other site
395961006083	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
395961006084	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961006085	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961006086	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961006087	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
395961006088	putative ADP-binding pocket [chemical binding]; other site
395961006089	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961006090	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961006091	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961006092	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
395961006093	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961006094	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
395961006095	active site
395961006096	catalytic triad [active]
395961006097	oxyanion hole [active]
395961006098	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
395961006099	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
395961006100	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961006101	active site
395961006102	motif I; other site
395961006103	motif II; other site
395961006104	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
395961006105	YciI-like protein; Reviewed; Region: PRK12864
395961006106	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
395961006107	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961006108	putative active site [active]
395961006109	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961006110	putative active site [active]
395961006111	Response regulator receiver domain; Region: Response_reg; pfam00072
395961006112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961006113	active site
395961006114	phosphorylation site [posttranslational modification]
395961006115	intermolecular recognition site; other site
395961006116	dimerization interface [polypeptide binding]; other site
395961006117	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961006118	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961006119	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961006120	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961006121	dimer interface [polypeptide binding]; other site
395961006122	phosphorylation site [posttranslational modification]
395961006123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961006124	ATP binding site [chemical binding]; other site
395961006125	Mg2+ binding site [ion binding]; other site
395961006126	G-X-G motif; other site
395961006127	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961006128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961006129	active site
395961006130	phosphorylation site [posttranslational modification]
395961006131	intermolecular recognition site; other site
395961006132	dimerization interface [polypeptide binding]; other site
395961006133	Response regulator receiver domain; Region: Response_reg; pfam00072
395961006134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961006135	active site
395961006136	phosphorylation site [posttranslational modification]
395961006137	intermolecular recognition site; other site
395961006138	dimerization interface [polypeptide binding]; other site
395961006139	Cupin domain; Region: Cupin_2; pfam07883
395961006140	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
395961006141	Protein kinase domain; Region: Pkinase; pfam00069
395961006142	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961006143	active site
395961006144	ATP binding site [chemical binding]; other site
395961006145	substrate binding site [chemical binding]; other site
395961006146	activation loop (A-loop); other site
395961006147	TIR domain; Region: TIR_2; pfam13676
395961006148	catalytic triad [active]
395961006149	Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335
395961006150	conserved cis-peptide bond; other site
395961006151	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
395961006152	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
395961006153	Protein phosphatase 2C; Region: PP2C_2; pfam13672
395961006154	S-layer homology domain; Region: SLH; pfam00395
395961006155	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
395961006156	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
395961006157	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961006158	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961006159	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961006160	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961006161	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961006162	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961006163	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961006164	glycine dehydrogenase; Provisional; Region: PRK05367
395961006165	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
395961006166	tetramer interface [polypeptide binding]; other site
395961006167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961006168	catalytic residue [active]
395961006169	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
395961006170	tetramer interface [polypeptide binding]; other site
395961006171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961006172	catalytic residue [active]
395961006173	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
395961006174	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
395961006175	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
395961006176	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
395961006177	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
395961006178	active site
395961006179	substrate binding site [chemical binding]; other site
395961006180	metal binding site [ion binding]; metal-binding site
395961006181	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
395961006182	hypothetical protein; Provisional; Region: PRK08317
395961006183	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961006184	S-adenosylmethionine binding site [chemical binding]; other site
395961006185	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
395961006186	Rubredoxin; Region: Rubredoxin; pfam00301
395961006187	iron binding site [ion binding]; other site
395961006188	Ycf48-like protein; Provisional; Region: PRK13684
395961006189	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
395961006190	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
395961006191	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
395961006192	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
395961006193	photosystem II reaction center protein J; Provisional; Region: PRK02565
395961006194	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
395961006195	O-succinylbenzoate synthase; Provisional; Region: PRK02714
395961006196	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
395961006197	active site
395961006198	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
395961006199	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
395961006200	acyl-activating enzyme (AAE) consensus motif; other site
395961006201	putative AMP binding site [chemical binding]; other site
395961006202	putative active site [active]
395961006203	putative CoA binding site [chemical binding]; other site
395961006204	CHASE domain; Region: CHASE; cl01369
395961006205	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006206	PAS fold; Region: PAS_3; pfam08447
395961006207	putative active site [active]
395961006208	heme pocket [chemical binding]; other site
395961006209	PAS domain S-box; Region: sensory_box; TIGR00229
395961006210	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006211	putative active site [active]
395961006212	heme pocket [chemical binding]; other site
395961006213	PAS domain S-box; Region: sensory_box; TIGR00229
395961006214	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006215	putative active site [active]
395961006216	heme pocket [chemical binding]; other site
395961006217	PAS domain S-box; Region: sensory_box; TIGR00229
395961006218	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006219	putative active site [active]
395961006220	heme pocket [chemical binding]; other site
395961006221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006222	PAS fold; Region: PAS_3; pfam08447
395961006223	putative active site [active]
395961006224	heme pocket [chemical binding]; other site
395961006225	hypothetical protein; Provisional; Region: PRK13560
395961006226	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006227	putative active site [active]
395961006228	heme pocket [chemical binding]; other site
395961006229	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006230	putative active site [active]
395961006231	heme pocket [chemical binding]; other site
395961006232	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006233	putative active site [active]
395961006234	heme pocket [chemical binding]; other site
395961006235	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006236	putative active site [active]
395961006237	heme pocket [chemical binding]; other site
395961006238	Histidine kinase; Region: HisKA_2; pfam07568
395961006239	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961006240	ATP binding site [chemical binding]; other site
395961006241	Mg2+ binding site [ion binding]; other site
395961006242	G-X-G motif; other site
395961006243	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
395961006244	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
395961006245	active site
395961006246	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
395961006247	active site
395961006248	(T/H)XGH motif; other site
395961006249	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
395961006250	nudix motif; other site
395961006251	NAD synthetase; Provisional; Region: PRK13981
395961006252	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
395961006253	multimer interface [polypeptide binding]; other site
395961006254	active site
395961006255	catalytic triad [active]
395961006256	protein interface 1 [polypeptide binding]; other site
395961006257	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
395961006258	homodimer interface [polypeptide binding]; other site
395961006259	NAD binding pocket [chemical binding]; other site
395961006260	ATP binding pocket [chemical binding]; other site
395961006261	Mg binding site [ion binding]; other site
395961006262	active-site loop [active]
395961006263	Cation efflux family; Region: Cation_efflux; cl00316
395961006264	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
395961006265	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
395961006266	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
395961006267	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
395961006268	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
395961006269	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
395961006270	ligand binding site [chemical binding]; other site
395961006271	homodimer interface [polypeptide binding]; other site
395961006272	NAD(P) binding site [chemical binding]; other site
395961006273	trimer interface B [polypeptide binding]; other site
395961006274	trimer interface A [polypeptide binding]; other site
395961006275	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
395961006276	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
395961006277	Catalytic site; other site
395961006278	Staphylococcal nuclease homologue; Region: SNase; pfam00565
395961006279	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
395961006280	catalytic site [active]
395961006281	putative active site [active]
395961006282	putative substrate binding site [chemical binding]; other site
395961006283	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
395961006284	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
395961006285	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395961006286	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
395961006287	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961006288	motif II; other site
395961006289	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
395961006290	recombination protein F; Reviewed; Region: recF; PRK00064
395961006291	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
395961006292	Walker A/P-loop; other site
395961006293	ATP binding site [chemical binding]; other site
395961006294	Q-loop/lid; other site
395961006295	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961006296	ABC transporter signature motif; other site
395961006297	Walker B; other site
395961006298	D-loop; other site
395961006299	H-loop/switch region; other site
395961006300	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
395961006301	UbiA prenyltransferase family; Region: UbiA; pfam01040
395961006302	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
395961006303	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
395961006304	Walker A/P-loop; other site
395961006305	ATP binding site [chemical binding]; other site
395961006306	Q-loop/lid; other site
395961006307	ABC transporter signature motif; other site
395961006308	Walker B; other site
395961006309	D-loop; other site
395961006310	H-loop/switch region; other site
395961006311	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
395961006312	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961006313	S-adenosylmethionine binding site [chemical binding]; other site
395961006314	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961006315	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961006316	Flagellin N-methylase; Region: FliB; cl00497
395961006317	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
395961006318	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
395961006319	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
395961006320	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
395961006321	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
395961006322	active site
395961006323	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961006324	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
395961006325	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395961006326	Walker A/P-loop; other site
395961006327	ATP binding site [chemical binding]; other site
395961006328	Q-loop/lid; other site
395961006329	ABC transporter signature motif; other site
395961006330	Walker B; other site
395961006331	D-loop; other site
395961006332	H-loop/switch region; other site
395961006333	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
395961006334	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395961006335	Walker A/P-loop; other site
395961006336	ATP binding site [chemical binding]; other site
395961006337	Q-loop/lid; other site
395961006338	ABC transporter signature motif; other site
395961006339	Walker B; other site
395961006340	D-loop; other site
395961006341	H-loop/switch region; other site
395961006342	tellurium resistance terB-like protein; Region: terB_like; cd07177
395961006343	metal binding site [ion binding]; metal-binding site
395961006344	tellurium resistance terB-like protein; Region: terB_like; cd07177
395961006345	metal binding site [ion binding]; metal-binding site
395961006346	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395961006347	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395961006348	TM-ABC transporter signature motif; other site
395961006349	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395961006350	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395961006351	TM-ABC transporter signature motif; other site
395961006352	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395961006353	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
395961006354	putative ligand binding site [chemical binding]; other site
395961006355	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
395961006356	G1 box; other site
395961006357	GTP/Mg2+ binding site [chemical binding]; other site
395961006358	G2 box; other site
395961006359	Switch I region; other site
395961006360	G3 box; other site
395961006361	Switch II region; other site
395961006362	G4 box; other site
395961006363	G5 box; other site
395961006364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961006365	S-adenosylmethionine binding site [chemical binding]; other site
395961006366	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
395961006367	UreF; Region: UreF; pfam01730
395961006368	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
395961006369	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
395961006370	dimer interface [polypeptide binding]; other site
395961006371	catalytic residues [active]
395961006372	urease subunit alpha; Reviewed; Region: ureC; PRK13207
395961006373	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
395961006374	subunit interactions [polypeptide binding]; other site
395961006375	active site
395961006376	flap region; other site
395961006377	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
395961006378	alpha-beta subunit interface [polypeptide binding]; other site
395961006379	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
395961006380	alpha-gamma subunit interface [polypeptide binding]; other site
395961006381	beta-gamma subunit interface [polypeptide binding]; other site
395961006382	NHL repeat; Region: NHL; pfam01436
395961006383	Uncharacterized conserved protein [Function unknown]; Region: COG3391
395961006384	NHL repeat; Region: NHL; pfam01436
395961006385	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
395961006386	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
395961006387	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
395961006388	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961006389	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395961006390	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961006391	binding surface
395961006392	TPR motif; other site
395961006393	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395961006394	phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418
395961006395	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
395961006396	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
395961006397	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
395961006398	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
395961006399	NB-ARC domain; Region: NB-ARC; pfam00931
395961006400	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961006401	transposase; Validated; Region: PRK08181
395961006402	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961006403	Walker A motif; other site
395961006404	ATP binding site [chemical binding]; other site
395961006405	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395961006406	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395961006407	Walker A/P-loop; other site
395961006408	ATP binding site [chemical binding]; other site
395961006409	Q-loop/lid; other site
395961006410	ABC transporter signature motif; other site
395961006411	Walker B; other site
395961006412	D-loop; other site
395961006413	H-loop/switch region; other site
395961006414	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395961006415	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395961006416	Walker A/P-loop; other site
395961006417	ATP binding site [chemical binding]; other site
395961006418	Q-loop/lid; other site
395961006419	ABC transporter signature motif; other site
395961006420	Walker B; other site
395961006421	D-loop; other site
395961006422	H-loop/switch region; other site
395961006423	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395961006424	Ycf48-like protein; Provisional; Region: PRK13684
395961006425	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
395961006426	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
395961006427	catalytic triad [active]
395961006428	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961006429	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961006430	active site
395961006431	ATP binding site [chemical binding]; other site
395961006432	substrate binding site [chemical binding]; other site
395961006433	activation loop (A-loop); other site
395961006434	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
395961006435	ResB-like family; Region: ResB; pfam05140
395961006436	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395961006437	RNA binding surface [nucleotide binding]; other site
395961006438	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
395961006439	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
395961006440	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
395961006441	NADH(P)-binding; Region: NAD_binding_10; pfam13460
395961006442	NAD(P) binding site [chemical binding]; other site
395961006443	putative active site [active]
395961006444	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
395961006445	catalytic residue [active]
395961006446	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961006447	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961006448	S-adenosylmethionine binding site [chemical binding]; other site
395961006449	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
395961006450	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
395961006451	Part of AAA domain; Region: AAA_19; pfam13245
395961006452	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
395961006453	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
395961006454	active site
395961006455	catalytic site [active]
395961006456	substrate binding site [chemical binding]; other site
395961006457	Family description; Region: UvrD_C_2; pfam13538
395961006458	urea carboxylase; Region: urea_carbox; TIGR02712
395961006459	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395961006460	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395961006461	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
395961006462	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
395961006463	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
395961006464	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395961006465	carboxyltransferase (CT) interaction site; other site
395961006466	biotinylation site [posttranslational modification]; other site
395961006467	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
395961006468	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
395961006469	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
395961006470	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
395961006471	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395961006472	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
395961006473	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395961006474	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395961006475	active site
395961006476	nucleophile elbow; other site
395961006477	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
395961006478	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
395961006479	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
395961006480	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
395961006481	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961006482	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961006483	GAF domain; Region: GAF; pfam01590
395961006484	PAS domain S-box; Region: sensory_box; TIGR00229
395961006485	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006486	putative active site [active]
395961006487	heme pocket [chemical binding]; other site
395961006488	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961006489	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961006490	ATP binding site [chemical binding]; other site
395961006491	Mg2+ binding site [ion binding]; other site
395961006492	G-X-G motif; other site
395961006493	histidinol-phosphate aminotransferase; Provisional; Region: PRK02610
395961006494	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395961006495	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961006496	homodimer interface [polypeptide binding]; other site
395961006497	catalytic residue [active]
395961006498	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395961006499	Protein of unknown function (DUF2459); Region: DUF2459; cl09819
395961006500	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
395961006501	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
395961006502	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
395961006503	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395961006504	RNA binding surface [nucleotide binding]; other site
395961006505	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
395961006506	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
395961006507	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
395961006508	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
395961006509	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
395961006510	P loop; other site
395961006511	GTP binding site [chemical binding]; other site
395961006512	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
395961006513	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961006514	motif II; other site
395961006515	Domain of unknown function DUF21; Region: DUF21; pfam01595
395961006516	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
395961006517	carotene isomerase; Region: carot_isom; TIGR02730
395961006518	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961006519	hydroxyglutarate oxidase; Provisional; Region: PRK11728
395961006520	light-harvesting-like protein 3; Provisional; Region: PLN00014
395961006521	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961006522	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961006523	phosphopeptide binding site; other site
395961006524	PAS domain S-box; Region: sensory_box; TIGR00229
395961006525	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961006526	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961006527	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961006528	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961006529	metal binding site [ion binding]; metal-binding site
395961006530	active site
395961006531	I-site; other site
395961006532	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961006533	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
395961006534	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
395961006535	oligomer interface [polypeptide binding]; other site
395961006536	metal binding site [ion binding]; metal-binding site
395961006537	metal binding site [ion binding]; metal-binding site
395961006538	Cl binding site [ion binding]; other site
395961006539	aspartate ring; other site
395961006540	basic sphincter; other site
395961006541	putative hydrophobic gate; other site
395961006542	periplasmic entrance; other site
395961006543	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
395961006544	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
395961006545	ring oligomerisation interface [polypeptide binding]; other site
395961006546	ATP/Mg binding site [chemical binding]; other site
395961006547	stacking interactions; other site
395961006548	hinge regions; other site
395961006549	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
395961006550	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961006551	putative substrate translocation pore; other site
395961006552	PAS domain S-box; Region: sensory_box; TIGR00229
395961006553	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006554	putative active site [active]
395961006555	heme pocket [chemical binding]; other site
395961006556	PAS fold; Region: PAS_3; pfam08447
395961006557	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006558	putative active site [active]
395961006559	heme pocket [chemical binding]; other site
395961006560	PAS domain S-box; Region: sensory_box; TIGR00229
395961006561	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006562	putative active site [active]
395961006563	heme pocket [chemical binding]; other site
395961006564	PAS fold; Region: PAS_4; pfam08448
395961006565	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006566	putative active site [active]
395961006567	heme pocket [chemical binding]; other site
395961006568	PAS domain S-box; Region: sensory_box; TIGR00229
395961006569	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006570	putative active site [active]
395961006571	heme pocket [chemical binding]; other site
395961006572	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006573	PAS fold; Region: PAS_3; pfam08447
395961006574	putative active site [active]
395961006575	heme pocket [chemical binding]; other site
395961006576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006577	PAS fold; Region: PAS_3; pfam08447
395961006578	putative active site [active]
395961006579	heme pocket [chemical binding]; other site
395961006580	PAS fold; Region: PAS_3; pfam08447
395961006581	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006582	heme pocket [chemical binding]; other site
395961006583	putative active site [active]
395961006584	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006585	PAS fold; Region: PAS_3; pfam08447
395961006586	putative active site [active]
395961006587	heme pocket [chemical binding]; other site
395961006588	PAS domain S-box; Region: sensory_box; TIGR00229
395961006589	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961006590	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006591	putative active site [active]
395961006592	heme pocket [chemical binding]; other site
395961006593	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006594	putative active site [active]
395961006595	heme pocket [chemical binding]; other site
395961006596	PAS domain S-box; Region: sensory_box; TIGR00229
395961006597	PAS fold; Region: PAS_3; pfam08447
395961006598	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006599	heme pocket [chemical binding]; other site
395961006600	putative active site [active]
395961006601	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006602	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961006603	putative active site [active]
395961006604	heme pocket [chemical binding]; other site
395961006605	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006606	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961006607	putative active site [active]
395961006608	heme pocket [chemical binding]; other site
395961006609	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006610	putative active site [active]
395961006611	heme pocket [chemical binding]; other site
395961006612	PAS domain S-box; Region: sensory_box; TIGR00229
395961006613	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006614	putative active site [active]
395961006615	heme pocket [chemical binding]; other site
395961006616	PAS domain S-box; Region: sensory_box; TIGR00229
395961006617	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006618	putative active site [active]
395961006619	heme pocket [chemical binding]; other site
395961006620	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006621	PAS fold; Region: PAS_3; pfam08447
395961006622	putative active site [active]
395961006623	heme pocket [chemical binding]; other site
395961006624	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006625	PAS fold; Region: PAS_3; pfam08447
395961006626	putative active site [active]
395961006627	heme pocket [chemical binding]; other site
395961006628	PAS fold; Region: PAS_4; pfam08448
395961006629	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006630	PAS fold; Region: PAS_3; pfam08447
395961006631	putative active site [active]
395961006632	heme pocket [chemical binding]; other site
395961006633	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006634	PAS fold; Region: PAS_3; pfam08447
395961006635	putative active site [active]
395961006636	heme pocket [chemical binding]; other site
395961006637	PAS fold; Region: PAS_3; pfam08447
395961006638	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006639	PAS fold; Region: PAS_3; pfam08447
395961006640	putative active site [active]
395961006641	heme pocket [chemical binding]; other site
395961006642	PAS fold; Region: PAS_4; pfam08448
395961006643	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961006644	putative active site [active]
395961006645	heme pocket [chemical binding]; other site
395961006646	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961006647	Histidine kinase; Region: HisKA_2; pfam07568
395961006648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961006649	ATP binding site [chemical binding]; other site
395961006650	Mg2+ binding site [ion binding]; other site
395961006651	G-X-G motif; other site
395961006652	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961006653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961006654	active site
395961006655	phosphorylation site [posttranslational modification]
395961006656	intermolecular recognition site; other site
395961006657	dimerization interface [polypeptide binding]; other site
395961006658	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961006659	Histidine kinase; Region: HisKA_2; pfam07568
395961006660	Integral membrane protein TerC family; Region: TerC; cl10468
395961006661	Photosystem I protein M (PsaM); Region: PsaM; pfam07465
395961006662	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
395961006663	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961006664	Walker A/P-loop; other site
395961006665	ATP binding site [chemical binding]; other site
395961006666	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
395961006667	FAD binding pocket [chemical binding]; other site
395961006668	conserved FAD binding motif [chemical binding]; other site
395961006669	phosphate binding motif [ion binding]; other site
395961006670	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
395961006671	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961006672	ABC transporter signature motif; other site
395961006673	Walker B; other site
395961006674	D-loop; other site
395961006675	H-loop/switch region; other site
395961006676	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
395961006677	active site
395961006678	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
395961006679	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395961006680	Zn2+ binding site [ion binding]; other site
395961006681	Mg2+ binding site [ion binding]; other site
395961006682	carboxyl-terminal processing protease; Provisional; Region: PLN00049
395961006683	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
395961006684	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
395961006685	protein binding site [polypeptide binding]; other site
395961006686	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
395961006687	Catalytic dyad [active]
395961006688	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
395961006689	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
395961006690	Qi binding site; other site
395961006691	intrachain domain interface; other site
395961006692	interchain domain interface [polypeptide binding]; other site
395961006693	heme bH binding site [chemical binding]; other site
395961006694	heme bL binding site [chemical binding]; other site
395961006695	Qo binding site; other site
395961006696	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
395961006697	interchain domain interface [polypeptide binding]; other site
395961006698	intrachain domain interface; other site
395961006699	Qi binding site; other site
395961006700	Qo binding site; other site
395961006701	Uncharacterized conserved protein [Function unknown]; Region: COG1565
395961006702	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
395961006703	ABC1 family; Region: ABC1; cl17513
395961006704	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
395961006705	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
395961006706	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
395961006707	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
395961006708	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961006709	dimer interface [polypeptide binding]; other site
395961006710	conserved gate region; other site
395961006711	putative PBP binding loops; other site
395961006712	ABC-ATPase subunit interface; other site
395961006713	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
395961006714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961006715	dimer interface [polypeptide binding]; other site
395961006716	conserved gate region; other site
395961006717	putative PBP binding loops; other site
395961006718	ABC-ATPase subunit interface; other site
395961006719	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
395961006720	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
395961006721	Walker A/P-loop; other site
395961006722	ATP binding site [chemical binding]; other site
395961006723	Q-loop/lid; other site
395961006724	ABC transporter signature motif; other site
395961006725	Walker B; other site
395961006726	D-loop; other site
395961006727	H-loop/switch region; other site
395961006728	tellurium resistance terB-like protein; Region: terB_like; cd07177
395961006729	metal binding site [ion binding]; metal-binding site
395961006730	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
395961006731	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961006732	FeS/SAM binding site; other site
395961006733	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
395961006734	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
395961006735	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
395961006736	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395961006737	catalytic residue [active]
395961006738	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
395961006739	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
395961006740	trimerization site [polypeptide binding]; other site
395961006741	active site
395961006742	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
395961006743	NifU-like domain; Region: NifU; pfam01106
395961006744	nitrogenase reductase; Reviewed; Region: PRK13236
395961006745	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
395961006746	Nucleotide-binding sites [chemical binding]; other site
395961006747	Walker A motif; other site
395961006748	Switch I region of nucleotide binding site; other site
395961006749	Fe4S4 binding sites [ion binding]; other site
395961006750	Switch II region of nucleotide binding site; other site
395961006751	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
395961006752	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
395961006753	MoFe protein alpha/beta subunit interactions; other site
395961006754	Alpha subunit P cluster binding residues; other site
395961006755	FeMoco binding residues [chemical binding]; other site
395961006756	MoFe protein alpha subunit/Fe protein contacts; other site
395961006757	MoFe protein dimer/ dimer interactions; other site
395961006758	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
395961006759	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
395961006760	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
395961006761	MoFe protein beta/alpha subunit interactions; other site
395961006762	Beta subunit P cluster binding residues; other site
395961006763	MoFe protein beta subunit/Fe protein contacts; other site
395961006764	MoFe protein dimer/ dimer interactions; other site
395961006765	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
395961006766	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
395961006767	active site
395961006768	catalytic residues [active]
395961006769	metal binding site [ion binding]; metal-binding site
395961006770	NifZ domain; Region: NifZ; pfam04319
395961006771	NifT/FixU protein; Region: NifT; pfam06988
395961006772	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
395961006773	dimer interface [polypeptide binding]; other site
395961006774	[2Fe-2S] cluster binding site [ion binding]; other site
395961006775	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961006776	putative active site [active]
395961006777	L-aspartate oxidase; Provisional; Region: PRK07395
395961006778	L-aspartate oxidase; Provisional; Region: PRK06175
395961006779	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
395961006780	L-aspartate oxidase; Provisional; Region: PRK07395
395961006781	L-aspartate oxidase; Provisional; Region: PRK06175
395961006782	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
395961006783	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
395961006784	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961006785	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961006786	phosphopeptide binding site; other site
395961006787	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395961006788	cyclase homology domain; Region: CHD; cd07302
395961006789	nucleotidyl binding site; other site
395961006790	metal binding site [ion binding]; metal-binding site
395961006791	dimer interface [polypeptide binding]; other site
395961006792	Permease; Region: Permease; cl00510
395961006793	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
395961006794	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961006795	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961006796	S-adenosylmethionine binding site [chemical binding]; other site
395961006797	Protein of unknown function (DUF938); Region: DUF938; pfam06080
395961006798	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
395961006799	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
395961006800	HD domain; Region: HD_5; pfam13487
395961006801	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961006802	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961006803	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961006804	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961006805	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961006806	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
395961006807	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
395961006808	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
395961006809	active site
395961006810	Riboflavin kinase; Region: Flavokinase; pfam01687
395961006811	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
395961006812	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
395961006813	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
395961006814	Hexamer interface [polypeptide binding]; other site
395961006815	Hexagonal pore residue; other site
395961006816	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
395961006817	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
395961006818	Peptidase family M50; Region: Peptidase_M50; pfam02163
395961006819	active site
395961006820	putative substrate binding region [chemical binding]; other site
395961006821	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395961006822	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
395961006823	putative C-terminal domain interface [polypeptide binding]; other site
395961006824	putative GSH binding site (G-site) [chemical binding]; other site
395961006825	putative dimer interface [polypeptide binding]; other site
395961006826	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395961006827	N-terminal domain interface [polypeptide binding]; other site
395961006828	dimer interface [polypeptide binding]; other site
395961006829	substrate binding pocket (H-site) [chemical binding]; other site
395961006830	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
395961006831	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961006832	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961006833	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395961006834	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395961006835	C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193
395961006836	putative N-terminal domain interface [polypeptide binding]; other site
395961006837	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
395961006838	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961006839	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961006840	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961006841	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
395961006842	dimer interface [polypeptide binding]; other site
395961006843	catalytic triad [active]
395961006844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
395961006845	conserved hypothetical protein; Region: TIGR03492
395961006846	V4R domain; Region: V4R; cl15268
395961006847	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
395961006848	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
395961006849	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
395961006850	G1 box; other site
395961006851	GTP/Mg2+ binding site [chemical binding]; other site
395961006852	G2 box; other site
395961006853	Switch I region; other site
395961006854	G3 box; other site
395961006855	Switch II region; other site
395961006856	G4 box; other site
395961006857	G5 box; other site
395961006858	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
395961006859	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
395961006860	heme-binding site [chemical binding]; other site
395961006861	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
395961006862	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
395961006863	generic binding surface I; other site
395961006864	generic binding surface II; other site
395961006865	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
395961006866	putative catalytic site [active]
395961006867	putative metal binding site [ion binding]; other site
395961006868	putative phosphate binding site [ion binding]; other site
395961006869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961006870	H+ Antiporter protein; Region: 2A0121; TIGR00900
395961006871	putative substrate translocation pore; other site
395961006872	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
395961006873	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
395961006874	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
395961006875	siderophore binding site; other site
395961006876	AMIN domain; Region: AMIN; pfam11741
395961006877	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
395961006878	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395961006879	N-terminal plug; other site
395961006880	ligand-binding site [chemical binding]; other site
395961006881	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395961006882	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395961006883	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395961006884	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961006885	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961006886	Walker A/P-loop; other site
395961006887	ATP binding site [chemical binding]; other site
395961006888	Q-loop/lid; other site
395961006889	ABC transporter signature motif; other site
395961006890	Walker B; other site
395961006891	D-loop; other site
395961006892	H-loop/switch region; other site
395961006893	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
395961006894	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
395961006895	siderophore binding site; other site
395961006896	AMIN domain; Region: AMIN; pfam11741
395961006897	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
395961006898	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395961006899	N-terminal plug; other site
395961006900	ligand-binding site [chemical binding]; other site
395961006901	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395961006902	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395961006903	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
395961006904	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
395961006905	Walker A/P-loop; other site
395961006906	ATP binding site [chemical binding]; other site
395961006907	Q-loop/lid; other site
395961006908	ABC transporter signature motif; other site
395961006909	Walker B; other site
395961006910	D-loop; other site
395961006911	H-loop/switch region; other site
395961006912	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
395961006913	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
395961006914	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
395961006915	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
395961006916	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
395961006917	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
395961006918	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
395961006919	Cytochrome P450; Region: p450; cl12078
395961006920	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961006921	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961006922	active site
395961006923	ATP binding site [chemical binding]; other site
395961006924	substrate binding site [chemical binding]; other site
395961006925	activation loop (A-loop); other site
395961006926	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
395961006927	Ycf46; Provisional; Region: ycf46; CHL00195
395961006928	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961006929	Walker A motif; other site
395961006930	ATP binding site [chemical binding]; other site
395961006931	Walker B motif; other site
395961006932	arginine finger; other site
395961006933	SWIM zinc finger; Region: SWIM; pfam04434
395961006934	MoxR-like ATPases [General function prediction only]; Region: COG0714
395961006935	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
395961006936	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
395961006937	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
395961006938	metal ion-dependent adhesion site (MIDAS); other site
395961006939	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
395961006940	active site
395961006941	catalytic site [active]
395961006942	substrate binding site [chemical binding]; other site
395961006943	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
395961006944	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
395961006945	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395961006946	ABC-ATPase subunit  interface; other site
395961006947	dimer interface [polypeptide binding]; other site
395961006948	putative PBP binding regions; other site
395961006949	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
395961006950	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395961006951	ABC-ATPase subunit  interface; other site
395961006952	dimer interface [polypeptide binding]; other site
395961006953	putative PBP binding regions; other site
395961006954	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395961006955	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961006956	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961006957	Walker A/P-loop; other site
395961006958	ATP binding site [chemical binding]; other site
395961006959	Q-loop/lid; other site
395961006960	ABC transporter signature motif; other site
395961006961	Walker B; other site
395961006962	D-loop; other site
395961006963	H-loop/switch region; other site
395961006964	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395961006965	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395961006966	AMIN domain; Region: AMIN; pfam11741
395961006967	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
395961006968	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395961006969	N-terminal plug; other site
395961006970	ligand-binding site [chemical binding]; other site
395961006971	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
395961006972	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
395961006973	siderophore binding site; other site
395961006974	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
395961006975	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
395961006976	Uncharacterized conserved protein [Function unknown]; Region: COG5464
395961006977	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961006978	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
395961006979	nucleotide binding site [chemical binding]; other site
395961006980	putative NEF/HSP70 interaction site [polypeptide binding]; other site
395961006981	SBD interface [polypeptide binding]; other site
395961006982	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
395961006983	dimer interface [polypeptide binding]; other site
395961006984	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
395961006985	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
395961006986	GUN4-like; Region: GUN4; pfam05419
395961006987	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
395961006988	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
395961006989	Substrate binding site; other site
395961006990	Mg++ binding site; other site
395961006991	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
395961006992	active site
395961006993	substrate binding site [chemical binding]; other site
395961006994	CoA binding site [chemical binding]; other site
395961006995	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
395961006996	TniQ; Region: TniQ; pfam06527
395961006997	AAA domain; Region: AAA_22; pfam13401
395961006998	AAA domain; Region: AAA_17; pfam13207
395961006999	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
395961007000	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
395961007001	Integrase core domain; Region: rve; pfam00665
395961007002	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
395961007003	HEAT repeats; Region: HEAT_2; pfam13646
395961007004	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395961007005	Walker A motif; other site
395961007006	ATP binding site [chemical binding]; other site
395961007007	Walker B motif; other site
395961007008	HEAT repeats; Region: HEAT_2; pfam13646
395961007009	HEAT repeats; Region: HEAT_2; pfam13646
395961007010	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395961007011	Uncharacterized conserved protein [Function unknown]; Region: COG1262
395961007012	WYL domain; Region: WYL; pfam13280
395961007013	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
395961007014	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
395961007015	CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712
395961007016	CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174
395961007017	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869
395961007018	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
395961007019	CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159
395961007020	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
395961007021	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
395961007022	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
395961007023	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
395961007024	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
395961007025	Protein of unknown function (DUF1247); Region: DUF1247; pfam06851
395961007026	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
395961007027	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961007028	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961007029	Winged helix-turn helix; Region: HTH_29; pfam13551
395961007030	Helix-turn-helix domain; Region: HTH_28; pfam13518
395961007031	Homeodomain-like domain; Region: HTH_32; pfam13565
395961007032	Uncharacterized conserved protein [Function unknown]; Region: COG1432
395961007033	LabA_like proteins; Region: LabA_like; cd06167
395961007034	putative metal binding site [ion binding]; other site
395961007035	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
395961007036	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395961007037	SurA N-terminal domain; Region: SurA_N; pfam09312
395961007038	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395961007039	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395961007040	Sulfatase; Region: Sulfatase; pfam00884
395961007041	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
395961007042	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
395961007043	translocon at the inner envelope of chloroplast subunit 62; Provisional; Region: PLN03209
395961007044	Uncharacterized conserved protein [Function unknown]; Region: COG5361
395961007045	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
395961007046	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
395961007047	Domain of unknown function (DUF202); Region: DUF202; cl09954
395961007048	Ion channel; Region: Ion_trans_2; pfam07885
395961007049	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961007050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961007051	active site
395961007052	phosphorylation site [posttranslational modification]
395961007053	intermolecular recognition site; other site
395961007054	dimerization interface [polypeptide binding]; other site
395961007055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395961007056	active site
395961007057	phosphorylation site [posttranslational modification]
395961007058	intermolecular recognition site; other site
395961007059	dimerization interface [polypeptide binding]; other site
395961007060	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961007061	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961007062	active site
395961007063	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
395961007064	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
395961007065	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
395961007066	homodimer interface [polypeptide binding]; other site
395961007067	substrate-cofactor binding pocket; other site
395961007068	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961007069	catalytic residue [active]
395961007070	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395961007071	IHF dimer interface [polypeptide binding]; other site
395961007072	IHF - DNA interface [nucleotide binding]; other site
395961007073	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395961007074	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
395961007075	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395961007076	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961007077	homodimer interface [polypeptide binding]; other site
395961007078	catalytic residue [active]
395961007079	TPR repeat; Region: TPR_11; pfam13414
395961007080	TPR repeat; Region: TPR_11; pfam13414
395961007081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007082	TPR motif; other site
395961007083	binding surface
395961007084	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395961007085	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007086	binding surface
395961007087	TPR motif; other site
395961007088	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007089	binding surface
395961007090	TPR motif; other site
395961007091	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007092	binding surface
395961007093	TPR motif; other site
395961007094	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007095	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395961007096	TPR motif; other site
395961007097	binding surface
395961007098	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961007099	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
395961007100	DALR anticodon binding domain; Region: DALR_1; smart00836
395961007101	anticodon binding site; other site
395961007102	tRNA binding surface [nucleotide binding]; other site
395961007103	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
395961007104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395961007105	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
395961007106	putative dimerization interface [polypeptide binding]; other site
395961007107	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
395961007108	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
395961007109	dimerization interface [polypeptide binding]; other site
395961007110	active site
395961007111	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
395961007112	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
395961007113	catalytic residues [active]
395961007114	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
395961007115	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961007116	Walker A/P-loop; other site
395961007117	ATP binding site [chemical binding]; other site
395961007118	Q-loop/lid; other site
395961007119	ABC transporter signature motif; other site
395961007120	Walker B; other site
395961007121	D-loop; other site
395961007122	H-loop/switch region; other site
395961007123	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
395961007124	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
395961007125	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961007126	putative active site [active]
395961007127	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
395961007128	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
395961007129	dimer interface [polypeptide binding]; other site
395961007130	active site
395961007131	CoA binding pocket [chemical binding]; other site
395961007132	putative phosphate acyltransferase; Provisional; Region: PRK05331
395961007133	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961007134	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961007135	phosphopeptide binding site; other site
395961007136	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
395961007137	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
395961007138	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961007139	Walker A motif; other site
395961007140	ATP binding site [chemical binding]; other site
395961007141	Walker B motif; other site
395961007142	arginine finger; other site
395961007143	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
395961007144	ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165
395961007145	Domain of unknown function (DUF309); Region: DUF309; pfam03745
395961007146	OstA-like protein; Region: OstA; pfam03968
395961007147	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
395961007148	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
395961007149	Walker A/P-loop; other site
395961007150	ATP binding site [chemical binding]; other site
395961007151	Q-loop/lid; other site
395961007152	ABC transporter signature motif; other site
395961007153	Walker B; other site
395961007154	D-loop; other site
395961007155	H-loop/switch region; other site
395961007156	Predicted permeases [General function prediction only]; Region: COG0795
395961007157	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
395961007158	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
395961007159	active site
395961007160	Protein of unknown function (DUF422); Region: DUF422; cl00991
395961007161	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
395961007162	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961007163	Coenzyme A binding pocket [chemical binding]; other site
395961007164	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
395961007165	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
395961007166	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
395961007167	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
395961007168	YceG-like family; Region: YceG; pfam02618
395961007169	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
395961007170	dimerization interface [polypeptide binding]; other site
395961007171	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
395961007172	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961007173	active site
395961007174	motif I; other site
395961007175	motif II; other site
395961007176	Ion channel; Region: Ion_trans_2; pfam07885
395961007177	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
395961007178	TrkA-N domain; Region: TrkA_N; pfam02254
395961007179	TrkA-C domain; Region: TrkA_C; pfam02080
395961007180	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
395961007181	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
395961007182	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
395961007183	thiamine phosphate binding site [chemical binding]; other site
395961007184	active site
395961007185	pyrophosphate binding site [ion binding]; other site
395961007186	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
395961007187	thiS-thiF/thiG interaction site; other site
395961007188	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
395961007189	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395961007190	metal binding site 2 [ion binding]; metal-binding site
395961007191	putative DNA binding helix; other site
395961007192	metal binding site 1 [ion binding]; metal-binding site
395961007193	dimer interface [polypeptide binding]; other site
395961007194	structural Zn2+ binding site [ion binding]; other site
395961007195	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
395961007196	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
395961007197	Cysteine-rich domain; Region: CCG; pfam02754
395961007198	Cysteine-rich domain; Region: CCG; pfam02754
395961007199	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
395961007200	PemK-like protein; Region: PemK; pfam02452
395961007201	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
395961007202	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961007203	dimer interface [polypeptide binding]; other site
395961007204	phosphorylation site [posttranslational modification]
395961007205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961007206	ATP binding site [chemical binding]; other site
395961007207	Mg2+ binding site [ion binding]; other site
395961007208	G-X-G motif; other site
395961007209	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
395961007210	5S rRNA interface [nucleotide binding]; other site
395961007211	CTC domain interface [polypeptide binding]; other site
395961007212	L16 interface [polypeptide binding]; other site
395961007213	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
395961007214	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
395961007215	GDP-binding site [chemical binding]; other site
395961007216	ACT binding site; other site
395961007217	IMP binding site; other site
395961007218	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
395961007219	active site
395961007220	catalytic residues [active]
395961007221	metal binding site [ion binding]; metal-binding site
395961007222	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
395961007223	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
395961007224	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
395961007225	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
395961007226	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
395961007227	dimerization interface [polypeptide binding]; other site
395961007228	active site
395961007229	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
395961007230	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
395961007231	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961007232	S-adenosylmethionine binding site [chemical binding]; other site
395961007233	methionine sulfoxide reductase A; Provisional; Region: PRK00058
395961007234	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
395961007235	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961007236	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395961007237	putative substrate translocation pore; other site
395961007238	Uncharacterized conserved protein [Function unknown]; Region: COG2442
395961007239	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
395961007240	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
395961007241	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395961007242	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
395961007243	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395961007244	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
395961007245	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
395961007246	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
395961007247	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
395961007248	putative active site [active]
395961007249	putative dimer interface [polypeptide binding]; other site
395961007250	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395961007251	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
395961007252	nucleotide binding site [chemical binding]; other site
395961007253	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961007254	putative active site [active]
395961007255	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395961007256	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395961007257	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
395961007258	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
395961007259	NADP binding site [chemical binding]; other site
395961007260	active site
395961007261	putative substrate binding site [chemical binding]; other site
395961007262	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
395961007263	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
395961007264	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007265	TPR motif; other site
395961007266	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
395961007267	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
395961007268	GTP/Mg2+ binding site [chemical binding]; other site
395961007269	G4 box; other site
395961007270	G5 box; other site
395961007271	G1 box; other site
395961007272	Switch I region; other site
395961007273	G2 box; other site
395961007274	G3 box; other site
395961007275	Switch II region; other site
395961007276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007277	TPR motif; other site
395961007278	TPR repeat; Region: TPR_11; pfam13414
395961007279	binding surface
395961007280	TPR repeat; Region: TPR_11; pfam13414
395961007281	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007282	binding surface
395961007283	TPR motif; other site
395961007284	TPR repeat; Region: TPR_11; pfam13414
395961007285	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
395961007286	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
395961007287	hinge; other site
395961007288	active site
395961007289	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
395961007290	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
395961007291	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961007292	Coenzyme A binding pocket [chemical binding]; other site
395961007293	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
395961007294	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
395961007295	Walker A/P-loop; other site
395961007296	ATP binding site [chemical binding]; other site
395961007297	Q-loop/lid; other site
395961007298	ABC transporter signature motif; other site
395961007299	Walker B; other site
395961007300	D-loop; other site
395961007301	H-loop/switch region; other site
395961007302	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007303	TPR motif; other site
395961007304	binding surface
395961007305	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395961007306	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
395961007307	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
395961007308	homopentamer interface [polypeptide binding]; other site
395961007309	active site
395961007310	Response regulator receiver domain; Region: Response_reg; pfam00072
395961007311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961007312	active site
395961007313	phosphorylation site [posttranslational modification]
395961007314	intermolecular recognition site; other site
395961007315	dimerization interface [polypeptide binding]; other site
395961007316	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961007317	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
395961007318	dimer interface [polypeptide binding]; other site
395961007319	phosphorylation site [posttranslational modification]
395961007320	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961007321	ATP binding site [chemical binding]; other site
395961007322	Mg2+ binding site [ion binding]; other site
395961007323	G-X-G motif; other site
395961007324	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
395961007325	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395961007326	Zn2+ binding site [ion binding]; other site
395961007327	Mg2+ binding site [ion binding]; other site
395961007328	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
395961007329	synthetase active site [active]
395961007330	NTP binding site [chemical binding]; other site
395961007331	metal binding site [ion binding]; metal-binding site
395961007332	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
395961007333	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
395961007334	Domain of unknown function (DUF4360); Region: DUF4360; pfam14273
395961007335	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961007336	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961007337	ligand binding site [chemical binding]; other site
395961007338	flexible hinge region; other site
395961007339	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395961007340	putative switch regulator; other site
395961007341	non-specific DNA interactions [nucleotide binding]; other site
395961007342	DNA binding site [nucleotide binding]
395961007343	sequence specific DNA binding site [nucleotide binding]; other site
395961007344	putative cAMP binding site [chemical binding]; other site
395961007345	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961007346	S-adenosylmethionine binding site [chemical binding]; other site
395961007347	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961007348	putative active site [active]
395961007349	tartrate dehydrogenase; Region: TTC; TIGR02089
395961007350	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
395961007351	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
395961007352	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
395961007353	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
395961007354	MAPEG family; Region: MAPEG; pfam01124
395961007355	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
395961007356	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
395961007357	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
395961007358	putative dimer interface [polypeptide binding]; other site
395961007359	N-terminal domain interface [polypeptide binding]; other site
395961007360	putative substrate binding pocket (H-site) [chemical binding]; other site
395961007361	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961007362	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961007363	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
395961007364	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
395961007365	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
395961007366	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395961007367	Beta-lactamase; Region: Beta-lactamase; pfam00144
395961007368	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
395961007369	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
395961007370	metal ion-dependent adhesion site (MIDAS); other site
395961007371	topology modulation protein; Reviewed; Region: PRK08118
395961007372	AAA domain; Region: AAA_17; pfam13207
395961007373	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
395961007374	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
395961007375	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
395961007376	AIR carboxylase; Region: AIRC; smart01001
395961007377	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
395961007378	antiporter inner membrane protein; Provisional; Region: PRK11670
395961007379	Domain of unknown function DUF59; Region: DUF59; pfam01883
395961007380	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
395961007381	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961007382	putative active site [active]
395961007383	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
395961007384	RNB domain; Region: RNB; pfam00773
395961007385	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
395961007386	dsRNA binding site [nucleotide binding]; other site
395961007387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961007388	S-adenosylmethionine binding site [chemical binding]; other site
395961007389	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
395961007390	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
395961007391	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
395961007392	PsbP; Region: PsbP; pfam01789
395961007393	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395961007394	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
395961007395	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395961007396	active site
395961007397	DNA binding site [nucleotide binding]
395961007398	Int/Topo IB signature motif; other site
395961007399	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
395961007400	Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250
395961007401	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
395961007402	active site
395961007403	ATP binding site [chemical binding]; other site
395961007404	substrate binding site [chemical binding]; other site
395961007405	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
395961007406	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395961007407	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
395961007408	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395961007409	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
395961007410	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
395961007411	active site
395961007412	Zn binding site [ion binding]; other site
395961007413	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395961007414	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
395961007415	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
395961007416	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
395961007417	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
395961007418	S-layer homology domain; Region: SLH; pfam00395
395961007419	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
395961007420	magnesium chelatase subunit H; Provisional; Region: PLN03241
395961007421	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395961007422	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395961007423	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
395961007424	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
395961007425	glutaminase active site [active]
395961007426	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
395961007427	dimer interface [polypeptide binding]; other site
395961007428	active site
395961007429	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
395961007430	dimer interface [polypeptide binding]; other site
395961007431	active site
395961007432	YcfA-like protein; Region: YcfA; pfam07927
395961007433	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
395961007434	AAA ATPase domain; Region: AAA_16; pfam13191
395961007435	Protein of unknown function (DUF433); Region: DUF433; pfam04255
395961007436	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
395961007437	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
395961007438	PIN domain; Region: PIN_3; cl17397
395961007439	Response regulator receiver domain; Region: Response_reg; pfam00072
395961007440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961007441	active site
395961007442	phosphorylation site [posttranslational modification]
395961007443	intermolecular recognition site; other site
395961007444	dimerization interface [polypeptide binding]; other site
395961007445	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961007446	non-specific DNA binding site [nucleotide binding]; other site
395961007447	sequence-specific DNA binding site [nucleotide binding]; other site
395961007448	salt bridge; other site
395961007449	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
395961007450	substrate binding site [chemical binding]; other site
395961007451	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
395961007452	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
395961007453	active site
395961007454	ADP/pyrophosphate binding site [chemical binding]; other site
395961007455	dimerization interface [polypeptide binding]; other site
395961007456	allosteric effector site; other site
395961007457	fructose-1,6-bisphosphate binding site; other site
395961007458	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
395961007459	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
395961007460	Erythromycin esterase; Region: Erythro_esteras; pfam05139
395961007461	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395961007462	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395961007463	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
395961007464	putative dimer interface [polypeptide binding]; other site
395961007465	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
395961007466	nickel binding site [ion binding]; other site
395961007467	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
395961007468	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
395961007469	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
395961007470	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
395961007471	FAD binding pocket [chemical binding]; other site
395961007472	FAD binding motif [chemical binding]; other site
395961007473	phosphate binding motif [ion binding]; other site
395961007474	beta-alpha-beta structure motif; other site
395961007475	NAD binding pocket [chemical binding]; other site
395961007476	Iron coordination center [ion binding]; other site
395961007477	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961007478	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961007479	ligand binding site [chemical binding]; other site
395961007480	flexible hinge region; other site
395961007481	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
395961007482	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
395961007483	META domain; Region: META; pfam03724
395961007484	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
395961007485	DDE superfamily endonuclease; Region: DDE_4; pfam13359
395961007486	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
395961007487	anti sigma factor interaction site; other site
395961007488	regulatory phosphorylation site [posttranslational modification]; other site
395961007489	Response regulator receiver domain; Region: Response_reg; pfam00072
395961007490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961007491	active site
395961007492	phosphorylation site [posttranslational modification]
395961007493	intermolecular recognition site; other site
395961007494	dimerization interface [polypeptide binding]; other site
395961007495	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
395961007496	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
395961007497	Heme NO binding associated; Region: HNOBA; pfam07701
395961007498	PAS domain; Region: PAS_8; pfam13188
395961007499	PAS domain S-box; Region: sensory_box; TIGR00229
395961007500	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961007501	PAS fold; Region: PAS_3; pfam08447
395961007502	putative active site [active]
395961007503	heme pocket [chemical binding]; other site
395961007504	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961007505	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961007506	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961007507	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961007508	dimer interface [polypeptide binding]; other site
395961007509	phosphorylation site [posttranslational modification]
395961007510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961007511	ATP binding site [chemical binding]; other site
395961007512	Mg2+ binding site [ion binding]; other site
395961007513	G-X-G motif; other site
395961007514	Response regulator receiver domain; Region: Response_reg; pfam00072
395961007515	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961007516	active site
395961007517	phosphorylation site [posttranslational modification]
395961007518	intermolecular recognition site; other site
395961007519	dimerization interface [polypeptide binding]; other site
395961007520	Response regulator receiver domain; Region: Response_reg; pfam00072
395961007521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961007522	active site
395961007523	phosphorylation site [posttranslational modification]
395961007524	intermolecular recognition site; other site
395961007525	dimerization interface [polypeptide binding]; other site
395961007526	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
395961007527	Heme NO binding; Region: HNOB; pfam07700
395961007528	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
395961007529	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
395961007530	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
395961007531	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
395961007532	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
395961007533	putative active site [active]
395961007534	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
395961007535	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
395961007536	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
395961007537	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961007538	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
395961007539	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961007540	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961007541	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
395961007542	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395961007543	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961007544	active site
395961007545	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961007546	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961007547	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
395961007548	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
395961007549	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
395961007550	anti sigma factor interaction site; other site
395961007551	regulatory phosphorylation site [posttranslational modification]; other site
395961007552	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
395961007553	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395961007554	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
395961007555	OsmC-like protein; Region: OsmC; cl00767
395961007556	TPR repeat; Region: TPR_11; pfam13414
395961007557	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007558	TPR motif; other site
395961007559	binding surface
395961007560	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395961007561	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
395961007562	catalytic site [active]
395961007563	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
395961007564	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
395961007565	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961007566	GAF domain; Region: GAF; pfam01590
395961007567	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961007568	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961007569	PAS domain S-box; Region: sensory_box; TIGR00229
395961007570	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961007571	putative active site [active]
395961007572	heme pocket [chemical binding]; other site
395961007573	PAS domain S-box; Region: sensory_box; TIGR00229
395961007574	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961007575	putative active site [active]
395961007576	heme pocket [chemical binding]; other site
395961007577	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961007578	dimer interface [polypeptide binding]; other site
395961007579	phosphorylation site [posttranslational modification]
395961007580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961007581	ATP binding site [chemical binding]; other site
395961007582	Mg2+ binding site [ion binding]; other site
395961007583	G-X-G motif; other site
395961007584	Response regulator receiver domain; Region: Response_reg; pfam00072
395961007585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961007586	active site
395961007587	phosphorylation site [posttranslational modification]
395961007588	intermolecular recognition site; other site
395961007589	dimerization interface [polypeptide binding]; other site
395961007590	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395961007591	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395961007592	protein binding site [polypeptide binding]; other site
395961007593	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395961007594	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395961007595	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
395961007596	Peptidase family M23; Region: Peptidase_M23; pfam01551
395961007597	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
395961007598	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
395961007599	putative active site [active]
395961007600	Zn binding site [ion binding]; other site
395961007601	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961007602	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961007603	phosphopeptide binding site; other site
395961007604	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961007605	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961007606	active site
395961007607	substrate binding site [chemical binding]; other site
395961007608	ATP binding site [chemical binding]; other site
395961007609	activation loop (A-loop); other site
395961007610	Double zinc ribbon; Region: DZR; pfam12773
395961007611	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
395961007612	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961007613	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961007614	phosphopeptide binding site; other site
395961007615	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
395961007616	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
395961007617	putative active site [active]
395961007618	acetolactate synthase; Reviewed; Region: PRK08322
395961007619	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395961007620	PYR/PP interface [polypeptide binding]; other site
395961007621	dimer interface [polypeptide binding]; other site
395961007622	TPP binding site [chemical binding]; other site
395961007623	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395961007624	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
395961007625	TPP-binding site [chemical binding]; other site
395961007626	dimer interface [polypeptide binding]; other site
395961007627	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
395961007628	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
395961007629	NAD(P) binding site [chemical binding]; other site
395961007630	catalytic residues [active]
395961007631	YacP-like NYN domain; Region: NYN_YacP; cl01491
395961007632	Transposase, Mutator family; Region: Transposase_mut; pfam00872
395961007633	MULE transposase domain; Region: MULE; pfam10551
395961007634	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
395961007635	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
395961007636	DNA binding residues [nucleotide binding]
395961007637	dimer interface [polypeptide binding]; other site
395961007638	metal binding site [ion binding]; metal-binding site
395961007639	light-harvesting-like protein 3; Provisional; Region: PLN00014
395961007640	hypothetical protein; Provisional; Region: PRK02509
395961007641	Uncharacterized conserved protein [Function unknown]; Region: COG1615
395961007642	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
395961007643	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
395961007644	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395961007645	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
395961007646	EcsC protein family; Region: EcsC; pfam12787
395961007647	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395961007648	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961007649	WHG domain; Region: WHG; pfam13305
395961007650	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
395961007651	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
395961007652	putative ligand binding site [chemical binding]; other site
395961007653	putative NAD binding site [chemical binding]; other site
395961007654	catalytic site [active]
395961007655	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
395961007656	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
395961007657	Uncharacterized conserved protein [Function unknown]; Region: COG1434
395961007658	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
395961007659	putative active site [active]
395961007660	fumarate hydratase; Reviewed; Region: fumC; PRK00485
395961007661	Class II fumarases; Region: Fumarase_classII; cd01362
395961007662	active site
395961007663	tetramer interface [polypeptide binding]; other site
395961007664	Predicted ATPases [General function prediction only]; Region: COG1106
395961007665	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
395961007666	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
395961007667	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
395961007668	Nitrogen regulatory protein P-II; Region: P-II; smart00938
395961007669	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
395961007670	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
395961007671	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
395961007672	shikimate binding site; other site
395961007673	NAD(P) binding site [chemical binding]; other site
395961007674	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
395961007675	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
395961007676	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
395961007677	Glycoprotease family; Region: Peptidase_M22; pfam00814
395961007678	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
395961007679	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395961007680	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395961007681	Walker A/P-loop; other site
395961007682	ATP binding site [chemical binding]; other site
395961007683	Q-loop/lid; other site
395961007684	ABC transporter signature motif; other site
395961007685	Walker B; other site
395961007686	D-loop; other site
395961007687	H-loop/switch region; other site
395961007688	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
395961007689	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
395961007690	NAD(P) binding site [chemical binding]; other site
395961007691	catalytic residues [active]
395961007692	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961007693	putative active site [active]
395961007694	recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341
395961007695	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961007696	Walker A motif; other site
395961007697	ATP binding site [chemical binding]; other site
395961007698	Walker B motif; other site
395961007699	arginine finger; other site
395961007700	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
395961007701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395961007702	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
395961007703	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
395961007704	serine endoprotease; Provisional; Region: PRK10898
395961007705	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395961007706	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395961007707	protein binding site [polypeptide binding]; other site
395961007708	cobyric acid synthase; Provisional; Region: PRK00784
395961007709	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961007710	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961007711	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
395961007712	catalytic triad [active]
395961007713	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
395961007714	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
395961007715	active site
395961007716	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
395961007717	MutS domain III; Region: MutS_III; pfam05192
395961007718	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
395961007719	Walker A/P-loop; other site
395961007720	ATP binding site [chemical binding]; other site
395961007721	Q-loop/lid; other site
395961007722	ABC transporter signature motif; other site
395961007723	Walker B; other site
395961007724	D-loop; other site
395961007725	H-loop/switch region; other site
395961007726	Smr domain; Region: Smr; pfam01713
395961007727	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
395961007728	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
395961007729	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395961007730	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
395961007731	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
395961007732	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395961007733	argininosuccinate lyase; Provisional; Region: PRK00855
395961007734	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
395961007735	active sites [active]
395961007736	tetramer interface [polypeptide binding]; other site
395961007737	Protein of unknown function, DUF399; Region: DUF399; pfam04187
395961007738	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
395961007739	DHH family; Region: DHH; pfam01368
395961007740	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395961007741	catalytic core [active]
395961007742	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
395961007743	proposed catalytic triad [active]
395961007744	active site nucleophile [active]
395961007745	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
395961007746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961007747	dimer interface [polypeptide binding]; other site
395961007748	conserved gate region; other site
395961007749	putative PBP binding loops; other site
395961007750	ABC-ATPase subunit interface; other site
395961007751	sulfate transport protein; Provisional; Region: cysT; CHL00187
395961007752	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961007753	dimer interface [polypeptide binding]; other site
395961007754	conserved gate region; other site
395961007755	putative PBP binding loops; other site
395961007756	ABC-ATPase subunit interface; other site
395961007757	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
395961007758	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395961007759	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
395961007760	META domain; Region: META; pfam03724
395961007761	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
395961007762	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
395961007763	Flagellin N-methylase; Region: FliB; cl00497
395961007764	PhoH-like protein; Region: PhoH; pfam02562
395961007765	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
395961007766	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
395961007767	KH domain; Region: KH_4; pfam13083
395961007768	ribosomal protein S16; Region: rps16; CHL00005
395961007769	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
395961007770	Methyltransferase domain; Region: Methyltransf_26; pfam13659
395961007771	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
395961007772	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
395961007773	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
395961007774	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
395961007775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
395961007776	Predicted kinase [General function prediction only]; Region: COG0645
395961007777	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
395961007778	ATP-binding site [chemical binding]; other site
395961007779	Gluconate-6-phosphate binding site [chemical binding]; other site
395961007780	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
395961007781	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
395961007782	DTAP/Switch II; other site
395961007783	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
395961007784	putative dimer interface [polypeptide binding]; other site
395961007785	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
395961007786	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
395961007787	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
395961007788	substrate binding site [chemical binding]; other site
395961007789	glutamase interaction surface [polypeptide binding]; other site
395961007790	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
395961007791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961007792	S-adenosylmethionine binding site [chemical binding]; other site
395961007793	DNA gyrase subunit A; Validated; Region: PRK05560
395961007794	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
395961007795	CAP-like domain; other site
395961007796	active site
395961007797	primary dimer interface [polypeptide binding]; other site
395961007798	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395961007799	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395961007800	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395961007801	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395961007802	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395961007803	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395961007804	Predicted membrane protein [Function unknown]; Region: COG4244
395961007805	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
395961007806	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
395961007807	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961007808	ATP binding site [chemical binding]; other site
395961007809	putative Mg++ binding site [ion binding]; other site
395961007810	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961007811	nucleotide binding region [chemical binding]; other site
395961007812	ATP-binding site [chemical binding]; other site
395961007813	TPR repeat; Region: TPR_11; pfam13414
395961007814	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007815	binding surface
395961007816	TPR motif; other site
395961007817	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007818	binding surface
395961007819	TPR motif; other site
395961007820	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007821	TPR motif; other site
395961007822	TPR repeat; Region: TPR_11; pfam13414
395961007823	binding surface
395961007824	TPR repeat; Region: TPR_11; pfam13414
395961007825	TPR repeat; Region: TPR_11; pfam13414
395961007826	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961007827	binding surface
395961007828	TPR motif; other site
395961007829	TPR repeat; Region: TPR_11; pfam13414
395961007830	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
395961007831	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961007832	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961007833	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
395961007834	glutaminase A; Region: Gln_ase; TIGR03814
395961007835	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
395961007836	Cache domain; Region: Cache_1; pfam02743
395961007837	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961007838	dimerization interface [polypeptide binding]; other site
395961007839	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
395961007840	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
395961007841	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
395961007842	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
395961007843	anti sigma factor interaction site; other site
395961007844	regulatory phosphorylation site [posttranslational modification]; other site
395961007845	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395961007846	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961007847	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961007848	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961007849	putative active site [active]
395961007850	heme pocket [chemical binding]; other site
395961007851	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961007852	putative active site [active]
395961007853	heme pocket [chemical binding]; other site
395961007854	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395961007855	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961007856	PAS fold; Region: PAS_3; pfam08447
395961007857	putative active site [active]
395961007858	heme pocket [chemical binding]; other site
395961007859	PAS domain S-box; Region: sensory_box; TIGR00229
395961007860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961007861	putative active site [active]
395961007862	heme pocket [chemical binding]; other site
395961007863	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961007864	dimerization interface [polypeptide binding]; other site
395961007865	PAS domain S-box; Region: sensory_box; TIGR00229
395961007866	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961007867	putative active site [active]
395961007868	heme pocket [chemical binding]; other site
395961007869	FeoA domain; Region: FeoA; pfam04023
395961007870	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
395961007871	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
395961007872	G1 box; other site
395961007873	GTP/Mg2+ binding site [chemical binding]; other site
395961007874	Switch I region; other site
395961007875	G2 box; other site
395961007876	G3 box; other site
395961007877	Switch II region; other site
395961007878	G4 box; other site
395961007879	G5 box; other site
395961007880	Nucleoside recognition; Region: Gate; pfam07670
395961007881	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
395961007882	Nucleoside recognition; Region: Gate; pfam07670
395961007883	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395961007884	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
395961007885	active site
395961007886	N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476
395961007887	Class I aldolases; Region: Aldolase_Class_I; cl17187
395961007888	catalytic residue [active]
395961007889	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
395961007890	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
395961007891	active site
395961007892	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961007893	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961007894	active site
395961007895	phosphorylation site [posttranslational modification]
395961007896	intermolecular recognition site; other site
395961007897	dimerization interface [polypeptide binding]; other site
395961007898	PAS fold; Region: PAS_3; pfam08447
395961007899	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961007900	heme pocket [chemical binding]; other site
395961007901	putative active site [active]
395961007902	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961007903	dimer interface [polypeptide binding]; other site
395961007904	phosphorylation site [posttranslational modification]
395961007905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961007906	ATP binding site [chemical binding]; other site
395961007907	Mg2+ binding site [ion binding]; other site
395961007908	G-X-G motif; other site
395961007909	Response regulator receiver domain; Region: Response_reg; pfam00072
395961007910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961007911	active site
395961007912	phosphorylation site [posttranslational modification]
395961007913	intermolecular recognition site; other site
395961007914	dimerization interface [polypeptide binding]; other site
395961007915	Response regulator receiver domain; Region: Response_reg; pfam00072
395961007916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961007917	active site
395961007918	phosphorylation site [posttranslational modification]
395961007919	intermolecular recognition site; other site
395961007920	dimerization interface [polypeptide binding]; other site
395961007921	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
395961007922	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
395961007923	putative active site [active]
395961007924	heme pocket [chemical binding]; other site
395961007925	GAF domain; Region: GAF; pfam01590
395961007926	Phytochrome region; Region: PHY; pfam00360
395961007927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961007928	dimer interface [polypeptide binding]; other site
395961007929	phosphorylation site [posttranslational modification]
395961007930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961007931	ATP binding site [chemical binding]; other site
395961007932	Mg2+ binding site [ion binding]; other site
395961007933	G-X-G motif; other site
395961007934	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961007935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961007936	active site
395961007937	phosphorylation site [posttranslational modification]
395961007938	intermolecular recognition site; other site
395961007939	dimerization interface [polypeptide binding]; other site
395961007940	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
395961007941	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
395961007942	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
395961007943	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
395961007944	active site clefts [active]
395961007945	zinc binding site [ion binding]; other site
395961007946	dimer interface [polypeptide binding]; other site
395961007947	Hemerythrin; Region: Hemerythrin; cd12107
395961007948	Fe binding site [ion binding]; other site
395961007949	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
395961007950	MgtC family; Region: MgtC; pfam02308
395961007951	Ribosomal protein S27; Region: Ribosomal_S27e; cl00897
395961007952	Double zinc ribbon; Region: DZR; pfam12773
395961007953	PBP superfamily domain; Region: PBP_like_2; cl17296
395961007954	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
395961007955	NIL domain; Region: NIL; pfam09383
395961007956	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395961007957	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395961007958	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
395961007959	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
395961007960	Walker A/P-loop; other site
395961007961	ATP binding site [chemical binding]; other site
395961007962	Q-loop/lid; other site
395961007963	ABC transporter signature motif; other site
395961007964	Walker B; other site
395961007965	D-loop; other site
395961007966	H-loop/switch region; other site
395961007967	TOBE-like domain; Region: TOBE_3; pfam12857
395961007968	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395961007969	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
395961007970	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
395961007971	active site
395961007972	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
395961007973	Domain of unknown function (DUF202); Region: DUF202; pfam02656
395961007974	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
395961007975	Cadmium resistance transporter; Region: Cad; pfam03596
395961007976	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
395961007977	Cadmium resistance transporter; Region: Cad; pfam03596
395961007978	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
395961007979	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395961007980	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
395961007981	putative dimerization interface [polypeptide binding]; other site
395961007982	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
395961007983	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
395961007984	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
395961007985	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
395961007986	dimer interface [polypeptide binding]; other site
395961007987	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961007988	catalytic residue [active]
395961007989	Rrf2 family protein; Region: rrf2_super; TIGR00738
395961007990	Transcriptional regulator; Region: Rrf2; pfam02082
395961007991	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
395961007992	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
395961007993	Chromate transporter; Region: Chromate_transp; pfam02417
395961007994	Putative phosphatase (DUF442); Region: DUF442; cl17385
395961007995	Predicted transcriptional regulators [Transcription]; Region: COG1695
395961007996	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
395961007997	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
395961007998	Transferrin; Region: Transferrin; cl02460
395961007999	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
395961008000	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
395961008001	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
395961008002	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
395961008003	homodimer interface [polypeptide binding]; other site
395961008004	substrate-cofactor binding pocket; other site
395961008005	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961008006	catalytic residue [active]
395961008007	Sulphur transport; Region: Sulf_transp; pfam04143
395961008008	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
395961008009	Syntaxin 6, N-terminal; Region: Syntaxin-6_N; pfam09177
395961008010	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
395961008011	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
395961008012	Active Sites [active]
395961008013	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
395961008014	Cadmium resistance transporter; Region: Cad; pfam03596
395961008015	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
395961008016	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961008017	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961008018	ligand binding site [chemical binding]; other site
395961008019	flexible hinge region; other site
395961008020	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395961008021	putative switch regulator; other site
395961008022	non-specific DNA interactions [nucleotide binding]; other site
395961008023	DNA binding site [nucleotide binding]
395961008024	sequence specific DNA binding site [nucleotide binding]; other site
395961008025	putative cAMP binding site [chemical binding]; other site
395961008026	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
395961008027	Phycobilisome protein; Region: Phycobilisome; cl08227
395961008028	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
395961008029	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
395961008030	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
395961008031	active site residue [active]
395961008032	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
395961008033	active site residue [active]
395961008034	Fatty acid desaturase; Region: FA_desaturase; pfam00487
395961008035	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
395961008036	Di-iron ligands [ion binding]; other site
395961008037	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
395961008038	acyl-CoA synthetase; Validated; Region: PRK05850
395961008039	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
395961008040	acyl-activating enzyme (AAE) consensus motif; other site
395961008041	active site
395961008042	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
395961008043	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
395961008044	putative di-iron ligands [ion binding]; other site
395961008045	Fatty acid desaturase; Region: FA_desaturase; pfam00487
395961008046	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
395961008047	putative di-iron ligands [ion binding]; other site
395961008048	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
395961008049	Fatty acid desaturase; Region: FA_desaturase; pfam00487
395961008050	Di-iron ligands [ion binding]; other site
395961008051	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
395961008052	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
395961008053	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
395961008054	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395961008055	substrate binding site [chemical binding]; other site
395961008056	oxyanion hole (OAH) forming residues; other site
395961008057	trimer interface [polypeptide binding]; other site
395961008058	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
395961008059	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
395961008060	active site
395961008061	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
395961008062	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
395961008063	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
395961008064	KR domain; Region: KR; pfam08659
395961008065	putative NADP binding site [chemical binding]; other site
395961008066	active site
395961008067	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
395961008068	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
395961008069	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
395961008070	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395961008071	substrate binding site [chemical binding]; other site
395961008072	oxyanion hole (OAH) forming residues; other site
395961008073	trimer interface [polypeptide binding]; other site
395961008074	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
395961008075	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
395961008076	dimer interface [polypeptide binding]; other site
395961008077	active site
395961008078	polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103
395961008079	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395961008080	dimer interface [polypeptide binding]; other site
395961008081	active site
395961008082	acyl carrier protein; Validated; Region: PRK07117
395961008083	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
395961008084	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
395961008085	active site
395961008086	Acyl transferase domain; Region: Acyl_transf_1; cl08282
395961008087	Acyl transferase domain; Region: Acyl_transf_1; cl08282
395961008088	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395961008089	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
395961008090	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
395961008091	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961008092	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
395961008093	HlyD family secretion protein; Region: HlyD_3; pfam13437
395961008094	DevC protein; Region: devC; TIGR01185
395961008095	FtsX-like permease family; Region: FtsX; pfam02687
395961008096	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
395961008097	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395961008098	Walker A/P-loop; other site
395961008099	ATP binding site [chemical binding]; other site
395961008100	Q-loop/lid; other site
395961008101	ABC transporter signature motif; other site
395961008102	Walker B; other site
395961008103	D-loop; other site
395961008104	H-loop/switch region; other site
395961008105	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961008106	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
395961008107	Ca2+ binding site [ion binding]; other site
395961008108	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
395961008109	EF-hand domain pair; Region: EF_hand_5; pfam13499
395961008110	Ca2+ binding site [ion binding]; other site
395961008111	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
395961008112	EF-hand domain pair; Region: EF_hand_5; pfam13499
395961008113	Ca2+ binding site [ion binding]; other site
395961008114	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395961008115	active site
395961008116	Int/Topo IB signature motif; other site
395961008117	DNA binding site [nucleotide binding]
395961008118	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395961008119	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395961008120	HEXXH motif domain; Region: mod_HExxH; TIGR04267
395961008121	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
395961008122	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
395961008123	active site
395961008124	zinc binding site [ion binding]; other site
395961008125	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
395961008126	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
395961008127	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395961008128	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
395961008129	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
395961008130	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395961008131	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395961008132	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961008133	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961008134	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961008135	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961008136	dimer interface [polypeptide binding]; other site
395961008137	phosphorylation site [posttranslational modification]
395961008138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961008139	ATP binding site [chemical binding]; other site
395961008140	Mg2+ binding site [ion binding]; other site
395961008141	G-X-G motif; other site
395961008142	Response regulator receiver domain; Region: Response_reg; pfam00072
395961008143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008144	active site
395961008145	phosphorylation site [posttranslational modification]
395961008146	intermolecular recognition site; other site
395961008147	dimerization interface [polypeptide binding]; other site
395961008148	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
395961008149	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
395961008150	DDE superfamily endonuclease; Region: DDE_4; pfam13359
395961008151	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
395961008152	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961008153	binding surface
395961008154	TPR motif; other site
395961008155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008156	Response regulator receiver domain; Region: Response_reg; pfam00072
395961008157	active site
395961008158	phosphorylation site [posttranslational modification]
395961008159	intermolecular recognition site; other site
395961008160	dimerization interface [polypeptide binding]; other site
395961008161	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
395961008162	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
395961008163	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395961008164	Walker A/P-loop; other site
395961008165	ATP binding site [chemical binding]; other site
395961008166	Q-loop/lid; other site
395961008167	ABC transporter signature motif; other site
395961008168	Walker B; other site
395961008169	D-loop; other site
395961008170	H-loop/switch region; other site
395961008171	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
395961008172	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
395961008173	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395961008174	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
395961008175	Cl- selectivity filter; other site
395961008176	Cl- binding residues [ion binding]; other site
395961008177	pore gating glutamate residue; other site
395961008178	dimer interface [polypeptide binding]; other site
395961008179	H+/Cl- coupling transport residue; other site
395961008180	FOG: CBS domain [General function prediction only]; Region: COG0517
395961008181	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
395961008182	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
395961008183	Ligand Binding Site [chemical binding]; other site
395961008184	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961008185	Ligand Binding Site [chemical binding]; other site
395961008186	Ion transport protein; Region: Ion_trans; pfam00520
395961008187	Ion channel; Region: Ion_trans_2; pfam07885
395961008188	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
395961008189	TrkA-N domain; Region: TrkA_N; pfam02254
395961008190	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
395961008191	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
395961008192	[2Fe-2S] cluster binding site [ion binding]; other site
395961008193	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
395961008194	hydrophobic ligand binding site; other site
395961008195	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
395961008196	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
395961008197	[2Fe-2S] cluster binding site [ion binding]; other site
395961008198	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
395961008199	hydrophobic ligand binding site; other site
395961008200	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961008201	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395961008202	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
395961008203	dimanganese center [ion binding]; other site
395961008204	7TM-HD extracellular; Region: 7TMR-HDED; pfam07697
395961008205	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
395961008206	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395961008207	Zn2+ binding site [ion binding]; other site
395961008208	Mg2+ binding site [ion binding]; other site
395961008209	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
395961008210	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
395961008211	putative ADP-binding pocket [chemical binding]; other site
395961008212	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961008213	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961008214	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961008215	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395961008216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008217	active site
395961008218	phosphorylation site [posttranslational modification]
395961008219	intermolecular recognition site; other site
395961008220	dimerization interface [polypeptide binding]; other site
395961008221	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395961008222	DNA binding site [nucleotide binding]
395961008223	CHASE3 domain; Region: CHASE3; pfam05227
395961008224	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961008225	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961008226	dimer interface [polypeptide binding]; other site
395961008227	phosphorylation site [posttranslational modification]
395961008228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961008229	ATP binding site [chemical binding]; other site
395961008230	Mg2+ binding site [ion binding]; other site
395961008231	G-X-G motif; other site
395961008232	EamA-like transporter family; Region: EamA; pfam00892
395961008233	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
395961008234	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
395961008235	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
395961008236	hydrophobic ligand binding site; other site
395961008237	Pheophorbide a oxygenase; Region: PaO; pfam08417
395961008238	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
395961008239	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
395961008240	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
395961008241	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961008242	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961008243	active site
395961008244	ATP binding site [chemical binding]; other site
395961008245	substrate binding site [chemical binding]; other site
395961008246	activation loop (A-loop); other site
395961008247	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395961008248	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395961008249	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395961008250	dimerization interface [polypeptide binding]; other site
395961008251	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
395961008252	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395961008253	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395961008254	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395961008255	putative effector binding pocket; other site
395961008256	dimerization interface [polypeptide binding]; other site
395961008257	SnoaL-like domain; Region: SnoaL_2; pfam12680
395961008258	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395961008259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008260	active site
395961008261	phosphorylation site [posttranslational modification]
395961008262	intermolecular recognition site; other site
395961008263	dimerization interface [polypeptide binding]; other site
395961008264	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395961008265	DNA binding site [nucleotide binding]
395961008266	Hpt domain; Region: Hpt; pfam01627
395961008267	Response regulator receiver domain; Region: Response_reg; pfam00072
395961008268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008269	active site
395961008270	phosphorylation site [posttranslational modification]
395961008271	intermolecular recognition site; other site
395961008272	dimerization interface [polypeptide binding]; other site
395961008273	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961008274	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961008275	metal binding site [ion binding]; metal-binding site
395961008276	active site
395961008277	I-site; other site
395961008278	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
395961008279	RibD C-terminal domain; Region: RibD_C; cl17279
395961008280	MAPEG family; Region: MAPEG; pfam01124
395961008281	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
395961008282	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
395961008283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008284	active site
395961008285	phosphorylation site [posttranslational modification]
395961008286	intermolecular recognition site; other site
395961008287	dimerization interface [polypeptide binding]; other site
395961008288	Response regulator receiver domain; Region: Response_reg; pfam00072
395961008289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008290	active site
395961008291	phosphorylation site [posttranslational modification]
395961008292	intermolecular recognition site; other site
395961008293	dimerization interface [polypeptide binding]; other site
395961008294	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395961008295	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008296	putative active site [active]
395961008297	heme pocket [chemical binding]; other site
395961008298	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961008299	dimer interface [polypeptide binding]; other site
395961008300	phosphorylation site [posttranslational modification]
395961008301	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961008302	ATP binding site [chemical binding]; other site
395961008303	Mg2+ binding site [ion binding]; other site
395961008304	G-X-G motif; other site
395961008305	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
395961008306	HAMP domain; Region: HAMP; pfam00672
395961008307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961008308	dimer interface [polypeptide binding]; other site
395961008309	phosphorylation site [posttranslational modification]
395961008310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961008311	ATP binding site [chemical binding]; other site
395961008312	Mg2+ binding site [ion binding]; other site
395961008313	G-X-G motif; other site
395961008314	Response regulator receiver domain; Region: Response_reg; pfam00072
395961008315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008316	active site
395961008317	phosphorylation site [posttranslational modification]
395961008318	intermolecular recognition site; other site
395961008319	dimerization interface [polypeptide binding]; other site
395961008320	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961008321	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961008322	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
395961008323	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
395961008324	active site
395961008325	dimer interface [polypeptide binding]; other site
395961008326	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
395961008327	Ligand Binding Site [chemical binding]; other site
395961008328	Molecular Tunnel; other site
395961008329	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cl00238
395961008330	AAA domain; Region: AAA_18; pfam13238
395961008331	AAA domain; Region: AAA_17; pfam13207
395961008332	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
395961008333	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
395961008334	P loop; other site
395961008335	Nucleotide binding site [chemical binding]; other site
395961008336	DTAP/Switch II; other site
395961008337	Switch I; other site
395961008338	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
395961008339	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395961008340	MarR family; Region: MarR; pfam01047
395961008341	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
395961008342	chaperone protein DnaJ; Provisional; Region: PRK14299
395961008343	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395961008344	HSP70 interaction site [polypeptide binding]; other site
395961008345	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
395961008346	substrate binding site [polypeptide binding]; other site
395961008347	dimer interface [polypeptide binding]; other site
395961008348	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395961008349	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395961008350	dimer interface [polypeptide binding]; other site
395961008351	putative CheW interface [polypeptide binding]; other site
395961008352	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
395961008353	heme binding pocket [chemical binding]; other site
395961008354	heme ligand [chemical binding]; other site
395961008355	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961008356	S-adenosylmethionine binding site [chemical binding]; other site
395961008357	Cupin domain; Region: Cupin_2; pfam07883
395961008358	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961008359	non-specific DNA binding site [nucleotide binding]; other site
395961008360	salt bridge; other site
395961008361	sequence-specific DNA binding site [nucleotide binding]; other site
395961008362	Clp amino terminal domain; Region: Clp_N; pfam02861
395961008363	Clp amino terminal domain; Region: Clp_N; pfam02861
395961008364	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
395961008365	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395961008366	active site
395961008367	NTP binding site [chemical binding]; other site
395961008368	metal binding triad [ion binding]; metal-binding site
395961008369	antibiotic binding site [chemical binding]; other site
395961008370	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
395961008371	Clp amino terminal domain; Region: Clp_N; pfam02861
395961008372	Clp amino terminal domain; Region: Clp_N; pfam02861
395961008373	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961008374	Walker A motif; other site
395961008375	ATP binding site [chemical binding]; other site
395961008376	Walker B motif; other site
395961008377	arginine finger; other site
395961008378	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961008379	Walker A motif; other site
395961008380	ATP binding site [chemical binding]; other site
395961008381	Walker B motif; other site
395961008382	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
395961008383	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395961008384	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395961008385	active site
395961008386	metal binding site [ion binding]; metal-binding site
395961008387	Dynamin family; Region: Dynamin_N; pfam00350
395961008388	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
395961008389	G1 box; other site
395961008390	GTP/Mg2+ binding site [chemical binding]; other site
395961008391	G2 box; other site
395961008392	Switch I region; other site
395961008393	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
395961008394	G3 box; other site
395961008395	Switch II region; other site
395961008396	GTP/Mg2+ binding site [chemical binding]; other site
395961008397	G4 box; other site
395961008398	G5 box; other site
395961008399	YjcZ-like protein; Region: YjcZ; pfam13990
395961008400	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961008401	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961008402	transposase; Validated; Region: PRK08181
395961008403	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961008404	Walker A motif; other site
395961008405	ATP binding site [chemical binding]; other site
395961008406	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395961008407	nucleophile elbow; other site
395961008408	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
395961008409	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
395961008410	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
395961008411	DDE superfamily endonuclease; Region: DDE_4; pfam13359
395961008412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961008413	S-adenosylmethionine binding site [chemical binding]; other site
395961008414	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395961008415	dimerization interface [polypeptide binding]; other site
395961008416	putative DNA binding site [nucleotide binding]; other site
395961008417	putative Zn2+ binding site [ion binding]; other site
395961008418	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
395961008419	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
395961008420	FMN binding site [chemical binding]; other site
395961008421	substrate binding site [chemical binding]; other site
395961008422	putative catalytic residue [active]
395961008423	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
395961008424	dinuclear metal binding motif [ion binding]; other site
395961008425	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
395961008426	pheophytin binding site; other site
395961008427	chlorophyll binding site; other site
395961008428	quinone binding site; other site
395961008429	Fe binding site [ion binding]; other site
395961008430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395961008431	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
395961008432	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
395961008433	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
395961008434	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961008435	Mg2+ binding site [ion binding]; other site
395961008436	G-X-G motif; other site
395961008437	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
395961008438	anchoring element; other site
395961008439	dimer interface [polypeptide binding]; other site
395961008440	ATP binding site [chemical binding]; other site
395961008441	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
395961008442	active site
395961008443	putative metal-binding site [ion binding]; other site
395961008444	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
395961008445	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
395961008446	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961008447	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
395961008448	catalytic triad [active]
395961008449	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961008450	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961008451	S-adenosylmethionine binding site [chemical binding]; other site
395961008452	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395961008453	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395961008454	Soluble P-type ATPase [General function prediction only]; Region: COG4087
395961008455	Uncharacterized conserved protein [Function unknown]; Region: COG1262
395961008456	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395961008457	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395961008458	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395961008459	Soluble P-type ATPase [General function prediction only]; Region: COG4087
395961008460	calcium/proton exchanger (cax); Region: cax; TIGR00378
395961008461	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
395961008462	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
395961008463	calcium/proton exchanger (cax); Region: cax; TIGR00378
395961008464	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
395961008465	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
395961008466	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
395961008467	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
395961008468	P loop; other site
395961008469	Nucleotide binding site [chemical binding]; other site
395961008470	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395961008471	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395961008472	chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029
395961008473	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
395961008474	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961008475	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961008476	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961008477	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
395961008478	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961008479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961008480	S-adenosylmethionine binding site [chemical binding]; other site
395961008481	TraX protein; Region: TraX; cl05434
395961008482	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
395961008483	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
395961008484	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
395961008485	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961008486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008487	active site
395961008488	phosphorylation site [posttranslational modification]
395961008489	intermolecular recognition site; other site
395961008490	dimerization interface [polypeptide binding]; other site
395961008491	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
395961008492	PAS domain; Region: PAS_9; pfam13426
395961008493	putative active site [active]
395961008494	heme pocket [chemical binding]; other site
395961008495	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961008496	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961008497	dimer interface [polypeptide binding]; other site
395961008498	phosphorylation site [posttranslational modification]
395961008499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961008500	ATP binding site [chemical binding]; other site
395961008501	Mg2+ binding site [ion binding]; other site
395961008502	G-X-G motif; other site
395961008503	Response regulator receiver domain; Region: Response_reg; pfam00072
395961008504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008505	active site
395961008506	phosphorylation site [posttranslational modification]
395961008507	intermolecular recognition site; other site
395961008508	dimerization interface [polypeptide binding]; other site
395961008509	PAS domain S-box; Region: sensory_box; TIGR00229
395961008510	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961008511	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008512	putative active site [active]
395961008513	heme pocket [chemical binding]; other site
395961008514	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008515	putative active site [active]
395961008516	heme pocket [chemical binding]; other site
395961008517	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961008518	GAF domain; Region: GAF; pfam01590
395961008519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008520	PAS fold; Region: PAS_3; pfam08447
395961008521	putative active site [active]
395961008522	heme pocket [chemical binding]; other site
395961008523	PAS domain S-box; Region: sensory_box; TIGR00229
395961008524	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008525	putative active site [active]
395961008526	heme pocket [chemical binding]; other site
395961008527	PAS fold; Region: PAS_4; pfam08448
395961008528	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008529	PAS fold; Region: PAS_3; pfam08447
395961008530	putative active site [active]
395961008531	heme pocket [chemical binding]; other site
395961008532	PAS fold; Region: PAS_4; pfam08448
395961008533	PAS fold; Region: PAS_4; pfam08448
395961008534	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008535	putative active site [active]
395961008536	heme pocket [chemical binding]; other site
395961008537	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961008538	dimer interface [polypeptide binding]; other site
395961008539	phosphorylation site [posttranslational modification]
395961008540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961008541	ATP binding site [chemical binding]; other site
395961008542	Mg2+ binding site [ion binding]; other site
395961008543	G-X-G motif; other site
395961008544	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961008545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008546	active site
395961008547	phosphorylation site [posttranslational modification]
395961008548	intermolecular recognition site; other site
395961008549	dimerization interface [polypeptide binding]; other site
395961008550	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395961008551	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008552	putative active site [active]
395961008553	heme pocket [chemical binding]; other site
395961008554	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961008555	dimer interface [polypeptide binding]; other site
395961008556	phosphorylation site [posttranslational modification]
395961008557	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961008558	ATP binding site [chemical binding]; other site
395961008559	Mg2+ binding site [ion binding]; other site
395961008560	G-X-G motif; other site
395961008561	Response regulator receiver domain; Region: Response_reg; pfam00072
395961008562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008563	active site
395961008564	phosphorylation site [posttranslational modification]
395961008565	intermolecular recognition site; other site
395961008566	dimerization interface [polypeptide binding]; other site
395961008567	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
395961008568	Winged helix-turn helix; Region: HTH_29; pfam13551
395961008569	Homeodomain-like domain; Region: HTH_32; pfam13565
395961008570	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961008571	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961008572	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
395961008573	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
395961008574	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961008575	S-adenosylmethionine binding site [chemical binding]; other site
395961008576	Domain of unknown function (DUF892); Region: DUF892; pfam05974
395961008577	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
395961008578	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
395961008579	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
395961008580	HIGH motif; other site
395961008581	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
395961008582	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395961008583	active site
395961008584	KMSKS motif; other site
395961008585	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
395961008586	tRNA binding surface [nucleotide binding]; other site
395961008587	NADH(P)-binding; Region: NAD_binding_10; pfam13460
395961008588	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
395961008589	NAD(P) binding site [chemical binding]; other site
395961008590	putative active site [active]
395961008591	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
395961008592	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
395961008593	Probable transposase; Region: OrfB_IS605; pfam01385
395961008594	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
395961008595	Nepovirus coat protein, C-terminal domain; Region: Nepo_coat_C; pfam03688
395961008596	HEAT repeats; Region: HEAT_2; pfam13646
395961008597	HEAT repeats; Region: HEAT_2; pfam13646
395961008598	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961008599	non-specific DNA binding site [nucleotide binding]; other site
395961008600	sequence-specific DNA binding site [nucleotide binding]; other site
395961008601	salt bridge; other site
395961008602	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
395961008603	HlyD family secretion protein; Region: HlyD_3; pfam13437
395961008604	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
395961008605	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
395961008606	putative active site [active]
395961008607	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961008608	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961008609	Walker A/P-loop; other site
395961008610	ATP binding site [chemical binding]; other site
395961008611	Q-loop/lid; other site
395961008612	ABC transporter signature motif; other site
395961008613	Walker B; other site
395961008614	D-loop; other site
395961008615	H-loop/switch region; other site
395961008616	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
395961008617	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961008618	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961008619	Walker A/P-loop; other site
395961008620	ATP binding site [chemical binding]; other site
395961008621	Q-loop/lid; other site
395961008622	ABC transporter signature motif; other site
395961008623	Walker B; other site
395961008624	D-loop; other site
395961008625	H-loop/switch region; other site
395961008626	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
395961008627	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395961008628	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
395961008629	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
395961008630	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
395961008631	active site
395961008632	zinc binding site [ion binding]; other site
395961008633	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
395961008634	nif11-like leader peptide domain; Region: ocin_TIGR03798
395961008635	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
395961008636	nif11-like leader peptide domain; Region: ocin_TIGR03798
395961008637	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
395961008638	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961008639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008640	phosphorylation site [posttranslational modification]
395961008641	intermolecular recognition site; other site
395961008642	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008643	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961008644	putative active site [active]
395961008645	heme pocket [chemical binding]; other site
395961008646	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008647	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961008648	putative active site [active]
395961008649	heme pocket [chemical binding]; other site
395961008650	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008651	putative active site [active]
395961008652	heme pocket [chemical binding]; other site
395961008653	Response regulator receiver domain; Region: Response_reg; pfam00072
395961008654	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008655	active site
395961008656	phosphorylation site [posttranslational modification]
395961008657	intermolecular recognition site; other site
395961008658	dimerization interface [polypeptide binding]; other site
395961008659	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
395961008660	putative metal binding site [ion binding]; other site
395961008661	nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103
395961008662	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961008663	FeS/SAM binding site; other site
395961008664	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
395961008665	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961008666	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961008667	active site
395961008668	ATP binding site [chemical binding]; other site
395961008669	substrate binding site [chemical binding]; other site
395961008670	activation loop (A-loop); other site
395961008671	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
395961008672	beta-galactosidase; Region: BGL; TIGR03356
395961008673	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395961008674	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
395961008675	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395961008676	active site
395961008677	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
395961008678	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
395961008679	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
395961008680	dimer interface [polypeptide binding]; other site
395961008681	active site
395961008682	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
395961008683	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
395961008684	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395961008685	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395961008686	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
395961008687	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395961008688	substrate binding site [chemical binding]; other site
395961008689	oxyanion hole (OAH) forming residues; other site
395961008690	trimer interface [polypeptide binding]; other site
395961008691	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
395961008692	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
395961008693	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
395961008694	acyl-activating enzyme (AAE) consensus motif; other site
395961008695	putative active site [active]
395961008696	putative AMP binding site [chemical binding]; other site
395961008697	putative CoA binding site [chemical binding]; other site
395961008698	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
395961008699	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395961008700	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395961008701	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395961008702	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
395961008703	putative DNA binding site [nucleotide binding]; other site
395961008704	putative Zn2+ binding site [ion binding]; other site
395961008705	AsnC family; Region: AsnC_trans_reg; pfam01037
395961008706	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395961008707	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395961008708	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
395961008709	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
395961008710	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
395961008711	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
395961008712	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
395961008713	XisH protein; Region: XisH; pfam08814
395961008714	XisI protein; Region: XisI; pfam08869
395961008715	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
395961008716	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
395961008717	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961008718	ATP binding site [chemical binding]; other site
395961008719	putative Mg++ binding site [ion binding]; other site
395961008720	transposase; Validated; Region: PRK08181
395961008721	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961008722	Walker A motif; other site
395961008723	ATP binding site [chemical binding]; other site
395961008724	YfdX protein; Region: YfdX; pfam10938
395961008725	Transposase, Mutator family; Region: Transposase_mut; pfam00872
395961008726	MULE transposase domain; Region: MULE; pfam10551
395961008727	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395961008728	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395961008729	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961008730	non-specific DNA binding site [nucleotide binding]; other site
395961008731	salt bridge; other site
395961008732	sequence-specific DNA binding site [nucleotide binding]; other site
395961008733	Double zinc ribbon; Region: DZR; pfam12773
395961008734	Uncharacterized conserved protein [Function unknown]; Region: COG1262
395961008735	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395961008736	PIN domain; Region: PIN_3; cl17397
395961008737	Uncharacterized conserved protein [Function unknown]; Region: COG1262
395961008738	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395961008739	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961008740	Walker A motif; other site
395961008741	ATP binding site [chemical binding]; other site
395961008742	Walker B motif; other site
395961008743	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961008744	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961008745	TIR domain; Region: TIR_2; pfam13676
395961008746	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
395961008747	DDE superfamily endonuclease; Region: DDE_4; pfam13359
395961008748	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395961008749	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
395961008750	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
395961008751	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
395961008752	HIGH motif; other site
395961008753	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
395961008754	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
395961008755	active site
395961008756	KMSKS motif; other site
395961008757	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
395961008758	tRNA binding surface [nucleotide binding]; other site
395961008759	anticodon binding site; other site
395961008760	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
395961008761	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961008762	putative active site [active]
395961008763	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
395961008764	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
395961008765	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
395961008766	generic binding surface II; other site
395961008767	generic binding surface I; other site
395961008768	PAS domain S-box; Region: sensory_box; TIGR00229
395961008769	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008770	putative active site [active]
395961008771	heme pocket [chemical binding]; other site
395961008772	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961008773	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961008774	dimer interface [polypeptide binding]; other site
395961008775	phosphorylation site [posttranslational modification]
395961008776	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961008777	ATP binding site [chemical binding]; other site
395961008778	Mg2+ binding site [ion binding]; other site
395961008779	G-X-G motif; other site
395961008780	CheB methylesterase; Region: CheB_methylest; pfam01339
395961008781	CheB methylesterase; Region: CheB_methylest; pfam01339
395961008782	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
395961008783	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
395961008784	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961008785	S-adenosylmethionine binding site [chemical binding]; other site
395961008786	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008787	PAS domain; Region: PAS_9; pfam13426
395961008788	putative active site [active]
395961008789	heme pocket [chemical binding]; other site
395961008790	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008791	PAS domain; Region: PAS_9; pfam13426
395961008792	putative active site [active]
395961008793	heme pocket [chemical binding]; other site
395961008794	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
395961008795	YcfA-like protein; Region: YcfA; pfam07927
395961008796	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
395961008797	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
395961008798	HD domain; Region: HD_4; pfam13328
395961008799	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
395961008800	Dynamin family; Region: Dynamin_N; pfam00350
395961008801	G1 box; other site
395961008802	GTP/Mg2+ binding site [chemical binding]; other site
395961008803	G2 box; other site
395961008804	Switch I region; other site
395961008805	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
395961008806	G3 box; other site
395961008807	Switch II region; other site
395961008808	GTP/Mg2+ binding site [chemical binding]; other site
395961008809	G4 box; other site
395961008810	G5 box; other site
395961008811	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
395961008812	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
395961008813	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
395961008814	ATP binding site [chemical binding]; other site
395961008815	putative Mg++ binding site [ion binding]; other site
395961008816	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
395961008817	TPR repeat; Region: TPR_11; pfam13414
395961008818	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961008819	binding surface
395961008820	HNH endonuclease; Region: HNH_2; pfam13391
395961008821	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
395961008822	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
395961008823	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
395961008824	Protein of unknown function DUF86; Region: DUF86; cl01031
395961008825	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395961008826	active site
395961008827	NTP binding site [chemical binding]; other site
395961008828	metal binding triad [ion binding]; metal-binding site
395961008829	antibiotic binding site [chemical binding]; other site
395961008830	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395961008831	active site
395961008832	NTP binding site [chemical binding]; other site
395961008833	metal binding triad [ion binding]; metal-binding site
395961008834	antibiotic binding site [chemical binding]; other site
395961008835	HsdM N-terminal domain; Region: HsdM_N; pfam12161
395961008836	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
395961008837	Methyltransferase domain; Region: Methyltransf_26; pfam13659
395961008838	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
395961008839	Part of AAA domain; Region: AAA_19; pfam13245
395961008840	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
395961008841	AAA domain; Region: AAA_12; pfam13087
395961008842	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
395961008843	putative active site [active]
395961008844	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
395961008845	AAA domain; Region: AAA_25; pfam13481
395961008846	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395961008847	Walker A motif; other site
395961008848	ATP binding site [chemical binding]; other site
395961008849	Walker B motif; other site
395961008850	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
395961008851	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
395961008852	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
395961008853	active site
395961008854	catalytic residues [active]
395961008855	DNA binding site [nucleotide binding]
395961008856	Int/Topo IB signature motif; other site
395961008857	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
395961008858	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
395961008859	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395961008860	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395961008861	catalytic residues [active]
395961008862	Predicted membrane protein [Function unknown]; Region: COG4094
395961008863	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961008864	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961008865	active site
395961008866	ATP binding site [chemical binding]; other site
395961008867	substrate binding site [chemical binding]; other site
395961008868	activation loop (A-loop); other site
395961008869	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
395961008870	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961008871	TPR motif; other site
395961008872	TPR repeat; Region: TPR_11; pfam13414
395961008873	binding surface
395961008874	Phycobilisome protein; Region: Phycobilisome; cl08227
395961008875	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395961008876	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395961008877	catalytic loop [active]
395961008878	iron binding site [ion binding]; other site
395961008879	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
395961008880	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
395961008881	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
395961008882	V4R domain; Region: V4R; pfam02830
395961008883	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
395961008884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
395961008885	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
395961008886	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961008887	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
395961008888	putative hydrophobic ligand binding site [chemical binding]; other site
395961008889	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961008890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008891	active site
395961008892	phosphorylation site [posttranslational modification]
395961008893	intermolecular recognition site; other site
395961008894	dimerization interface [polypeptide binding]; other site
395961008895	PAS fold; Region: PAS; pfam00989
395961008896	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961008897	putative active site [active]
395961008898	heme pocket [chemical binding]; other site
395961008899	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961008900	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961008901	metal binding site [ion binding]; metal-binding site
395961008902	active site
395961008903	I-site; other site
395961008904	PRC-barrel domain; Region: PRC; pfam05239
395961008905	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
395961008906	TPR repeat; Region: TPR_11; pfam13414
395961008907	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961008908	binding surface
395961008909	TPR repeat; Region: TPR_11; pfam13414
395961008910	TPR motif; other site
395961008911	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
395961008912	Domain of unknown function (DUF3474); Region: DUF3474; pfam11960
395961008913	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
395961008914	putative di-iron ligands [ion binding]; other site
395961008915	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
395961008916	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395961008917	putative NAD(P) binding site [chemical binding]; other site
395961008918	YcfA-like protein; Region: YcfA; cl00752
395961008919	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
395961008920	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
395961008921	Protein of unknown function (DUF433); Region: DUF433; pfam04255
395961008922	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
395961008923	YcfA-like protein; Region: YcfA; pfam07927
395961008924	Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041
395961008925	Predicted helicase [General function prediction only]; Region: COG4889
395961008926	Predicted helicase [General function prediction only]; Region: COG4889
395961008927	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
395961008928	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
395961008929	HIGH motif; other site
395961008930	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
395961008931	active site
395961008932	KMSKS motif; other site
395961008933	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
395961008934	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
395961008935	putative active site [active]
395961008936	catalytic triad [active]
395961008937	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395961008938	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961008939	Coenzyme A binding pocket [chemical binding]; other site
395961008940	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
395961008941	4Fe-4S binding domain; Region: Fer4; cl02805
395961008942	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
395961008943	Uncharacterized conserved protein [Function unknown]; Region: COG0327
395961008944	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
395961008945	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
395961008946	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
395961008947	Probable transposase; Region: OrfB_IS605; pfam01385
395961008948	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
395961008949	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
395961008950	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
395961008951	metal ion-dependent adhesion site (MIDAS); other site
395961008952	Nuclease-related domain; Region: NERD; pfam08378
395961008953	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
395961008954	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
395961008955	substrate binding site [chemical binding]; other site
395961008956	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
395961008957	substrate binding site [chemical binding]; other site
395961008958	ligand binding site [chemical binding]; other site
395961008959	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961008960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961008961	S-adenosylmethionine binding site [chemical binding]; other site
395961008962	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
395961008963	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
395961008964	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
395961008965	TrkA-N domain; Region: TrkA_N; pfam02254
395961008966	TrkA-C domain; Region: TrkA_C; pfam02080
395961008967	Response regulator receiver domain; Region: Response_reg; pfam00072
395961008968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008969	active site
395961008970	phosphorylation site [posttranslational modification]
395961008971	intermolecular recognition site; other site
395961008972	dimerization interface [polypeptide binding]; other site
395961008973	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961008974	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961008975	metal binding site [ion binding]; metal-binding site
395961008976	active site
395961008977	I-site; other site
395961008978	CHASE4 domain; Region: CHASE4; cl01308
395961008979	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961008980	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961008981	dimer interface [polypeptide binding]; other site
395961008982	phosphorylation site [posttranslational modification]
395961008983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961008984	ATP binding site [chemical binding]; other site
395961008985	Mg2+ binding site [ion binding]; other site
395961008986	G-X-G motif; other site
395961008987	Response regulator receiver domain; Region: Response_reg; pfam00072
395961008988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961008989	active site
395961008990	phosphorylation site [posttranslational modification]
395961008991	intermolecular recognition site; other site
395961008992	dimerization interface [polypeptide binding]; other site
395961008993	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961008994	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961008995	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961008996	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961008997	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
395961008998	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
395961008999	putative active site [active]
395961009000	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
395961009001	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
395961009002	putative active site [active]
395961009003	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395961009004	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395961009005	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
395961009006	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
395961009007	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
395961009008	TspO/MBR family; Region: TspO_MBR; cl01379
395961009009	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395961009010	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395961009011	active site
395961009012	catalytic tetrad [active]
395961009013	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
395961009014	Uncharacterized conserved protein [Function unknown]; Region: COG3268
395961009015	baseplate wedge subunit; Provisional; Region: 7; PHA02579
395961009016	high affinity sulphate transporter 1; Region: sulP; TIGR00815
395961009017	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
395961009018	Sulfate transporter family; Region: Sulfate_transp; pfam00916
395961009019	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
395961009020	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395961009021	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961009022	putative substrate translocation pore; other site
395961009023	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
395961009024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961009025	S-adenosylmethionine binding site [chemical binding]; other site
395961009026	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
395961009027	active site
395961009028	catalytic triad [active]
395961009029	oxyanion hole [active]
395961009030	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395961009031	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
395961009032	putative NAD(P) binding site [chemical binding]; other site
395961009033	active site
395961009034	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
395961009035	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
395961009036	HflX GTPase family; Region: HflX; cd01878
395961009037	G1 box; other site
395961009038	GTP/Mg2+ binding site [chemical binding]; other site
395961009039	Switch I region; other site
395961009040	G2 box; other site
395961009041	G3 box; other site
395961009042	Switch II region; other site
395961009043	G4 box; other site
395961009044	G5 box; other site
395961009045	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
395961009046	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
395961009047	active site
395961009048	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
395961009049	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
395961009050	Beta-lactamase; Region: Beta-lactamase; pfam00144
395961009051	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395961009052	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
395961009053	Histidine kinase; Region: HisKA_3; pfam07730
395961009054	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961009055	ATP binding site [chemical binding]; other site
395961009056	Mg2+ binding site [ion binding]; other site
395961009057	G-X-G motif; other site
395961009058	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395961009059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961009060	active site
395961009061	phosphorylation site [posttranslational modification]
395961009062	intermolecular recognition site; other site
395961009063	dimerization interface [polypeptide binding]; other site
395961009064	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395961009065	DNA binding residues [nucleotide binding]
395961009066	dimerization interface [polypeptide binding]; other site
395961009067	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395961009068	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395961009069	Walker A/P-loop; other site
395961009070	ATP binding site [chemical binding]; other site
395961009071	Q-loop/lid; other site
395961009072	ABC transporter signature motif; other site
395961009073	Walker B; other site
395961009074	D-loop; other site
395961009075	H-loop/switch region; other site
395961009076	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
395961009077	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395961009078	Walker A/P-loop; other site
395961009079	ATP binding site [chemical binding]; other site
395961009080	Q-loop/lid; other site
395961009081	ABC transporter signature motif; other site
395961009082	Walker B; other site
395961009083	D-loop; other site
395961009084	H-loop/switch region; other site
395961009085	allophanate hydrolase; Provisional; Region: PRK08186
395961009086	Amidase; Region: Amidase; pfam01425
395961009087	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
395961009088	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
395961009089	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
395961009090	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395961009091	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395961009092	Walker A/P-loop; other site
395961009093	ATP binding site [chemical binding]; other site
395961009094	Q-loop/lid; other site
395961009095	ABC transporter signature motif; other site
395961009096	Walker B; other site
395961009097	D-loop; other site
395961009098	H-loop/switch region; other site
395961009099	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395961009100	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961009101	dimer interface [polypeptide binding]; other site
395961009102	conserved gate region; other site
395961009103	putative PBP binding loops; other site
395961009104	ABC-ATPase subunit interface; other site
395961009105	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395961009106	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
395961009107	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
395961009108	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
395961009109	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395961009110	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395961009111	DNA binding residues [nucleotide binding]
395961009112	SnoaL-like domain; Region: SnoaL_2; pfam12680
395961009113	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
395961009114	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395961009115	ABC-ATPase subunit  interface; other site
395961009116	dimer interface [polypeptide binding]; other site
395961009117	putative PBP binding regions; other site
395961009118	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
395961009119	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
395961009120	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
395961009121	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
395961009122	metal binding site [ion binding]; metal-binding site
395961009123	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961009124	putative active site [active]
395961009125	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395961009126	active site
395961009127	NTP binding site [chemical binding]; other site
395961009128	metal binding triad [ion binding]; metal-binding site
395961009129	antibiotic binding site [chemical binding]; other site
395961009130	threonine dehydratase; Reviewed; Region: PRK09224
395961009131	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
395961009132	tetramer interface [polypeptide binding]; other site
395961009133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961009134	catalytic residue [active]
395961009135	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
395961009136	putative Ile/Val binding site [chemical binding]; other site
395961009137	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
395961009138	putative Ile/Val binding site [chemical binding]; other site
395961009139	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
395961009140	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009141	PAS fold; Region: PAS_4; pfam08448
395961009142	putative active site [active]
395961009143	heme pocket [chemical binding]; other site
395961009144	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395961009145	PAS domain; Region: PAS; smart00091
395961009146	putative active site [active]
395961009147	heme pocket [chemical binding]; other site
395961009148	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961009149	dimer interface [polypeptide binding]; other site
395961009150	phosphorylation site [posttranslational modification]
395961009151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961009152	ATP binding site [chemical binding]; other site
395961009153	Mg2+ binding site [ion binding]; other site
395961009154	G-X-G motif; other site
395961009155	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961009156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961009157	active site
395961009158	phosphorylation site [posttranslational modification]
395961009159	intermolecular recognition site; other site
395961009160	dimerization interface [polypeptide binding]; other site
395961009161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
395961009162	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961009163	Coenzyme A binding pocket [chemical binding]; other site
395961009164	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
395961009165	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
395961009166	active site
395961009167	interdomain interaction site; other site
395961009168	putative metal-binding site [ion binding]; other site
395961009169	nucleotide binding site [chemical binding]; other site
395961009170	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
395961009171	domain I; other site
395961009172	DNA binding groove [nucleotide binding]
395961009173	phosphate binding site [ion binding]; other site
395961009174	domain II; other site
395961009175	domain III; other site
395961009176	nucleotide binding site [chemical binding]; other site
395961009177	catalytic site [active]
395961009178	domain IV; other site
395961009179	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395961009180	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395961009181	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395961009182	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961009183	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009184	putative active site [active]
395961009185	heme pocket [chemical binding]; other site
395961009186	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009187	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961009188	putative active site [active]
395961009189	heme pocket [chemical binding]; other site
395961009190	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009191	putative active site [active]
395961009192	heme pocket [chemical binding]; other site
395961009193	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009194	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961009195	putative active site [active]
395961009196	heme pocket [chemical binding]; other site
395961009197	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009198	putative active site [active]
395961009199	heme pocket [chemical binding]; other site
395961009200	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961009201	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961009202	metal binding site [ion binding]; metal-binding site
395961009203	active site
395961009204	I-site; other site
395961009205	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961009206	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395961009207	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395961009208	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
395961009209	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
395961009210	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395961009211	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961009212	dimerization interface [polypeptide binding]; other site
395961009213	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395961009214	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009215	putative active site [active]
395961009216	heme pocket [chemical binding]; other site
395961009217	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961009218	dimer interface [polypeptide binding]; other site
395961009219	phosphorylation site [posttranslational modification]
395961009220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961009221	ATP binding site [chemical binding]; other site
395961009222	Mg2+ binding site [ion binding]; other site
395961009223	G-X-G motif; other site
395961009224	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395961009225	FOG: CBS domain [General function prediction only]; Region: COG0517
395961009226	GAF domain; Region: GAF; pfam01590
395961009227	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009228	PAS fold; Region: PAS_3; pfam08447
395961009229	putative active site [active]
395961009230	heme pocket [chemical binding]; other site
395961009231	PAS fold; Region: PAS_4; pfam08448
395961009232	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009233	putative active site [active]
395961009234	heme pocket [chemical binding]; other site
395961009235	PAS domain S-box; Region: sensory_box; TIGR00229
395961009236	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009237	putative active site [active]
395961009238	heme pocket [chemical binding]; other site
395961009239	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961009240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961009241	dimer interface [polypeptide binding]; other site
395961009242	phosphorylation site [posttranslational modification]
395961009243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961009244	ATP binding site [chemical binding]; other site
395961009245	Mg2+ binding site [ion binding]; other site
395961009246	G-X-G motif; other site
395961009247	Response regulator receiver domain; Region: Response_reg; pfam00072
395961009248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961009249	active site
395961009250	phosphorylation site [posttranslational modification]
395961009251	intermolecular recognition site; other site
395961009252	dimerization interface [polypeptide binding]; other site
395961009253	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
395961009254	putative binding surface; other site
395961009255	active site
395961009256	FO synthase subunit 2; Reviewed; Region: PRK07360
395961009257	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961009258	FeS/SAM binding site; other site
395961009259	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961009260	putative active site [active]
395961009261	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
395961009262	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
395961009263	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
395961009264	active site clefts [active]
395961009265	zinc binding site [ion binding]; other site
395961009266	dimer interface [polypeptide binding]; other site
395961009267	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
395961009268	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395961009269	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395961009270	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395961009271	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
395961009272	Circadian oscillating protein COP23; Region: COP23; pfam14218
395961009273	glutathione reductase; Validated; Region: PRK06116
395961009274	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395961009275	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395961009276	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395961009277	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
395961009278	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
395961009279	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
395961009280	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
395961009281	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395961009282	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
395961009283	NAD binding site [chemical binding]; other site
395961009284	putative substrate binding site 2 [chemical binding]; other site
395961009285	putative substrate binding site 1 [chemical binding]; other site
395961009286	active site
395961009287	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
395961009288	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
395961009289	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
395961009290	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
395961009291	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
395961009292	Protein of unknown function (DUF433); Region: DUF433; cl01030
395961009293	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
395961009294	Winged helix-turn helix; Region: HTH_29; pfam13551
395961009295	Homeodomain-like domain; Region: HTH_32; pfam13565
395961009296	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961009297	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961009298	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
395961009299	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
395961009300	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
395961009301	dimer interface [polypeptide binding]; other site
395961009302	motif 1; other site
395961009303	active site
395961009304	motif 2; other site
395961009305	motif 3; other site
395961009306	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
395961009307	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961009308	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395961009309	classical (c) SDRs; Region: SDR_c; cd05233
395961009310	NAD(P) binding site [chemical binding]; other site
395961009311	active site
395961009312	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
395961009313	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
395961009314	active site
395961009315	(T/H)XGH motif; other site
395961009316	ribosomal protein S14; Region: rps14; CHL00074
395961009317	MEKHLA domain; Region: MEKHLA; pfam08670
395961009318	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
395961009319	RNA/DNA hybrid binding site [nucleotide binding]; other site
395961009320	active site
395961009321	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
395961009322	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
395961009323	Ligand Binding Site [chemical binding]; other site
395961009324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395961009325	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
395961009326	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395961009327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961009328	dimer interface [polypeptide binding]; other site
395961009329	conserved gate region; other site
395961009330	ABC-ATPase subunit interface; other site
395961009331	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
395961009332	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961009333	binding surface
395961009334	TPR motif; other site
395961009335	TPR repeat; Region: TPR_11; pfam13414
395961009336	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395961009337	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395961009338	substrate binding pocket [chemical binding]; other site
395961009339	membrane-bound complex binding site; other site
395961009340	hinge residues; other site
395961009341	Iron permease FTR1 family; Region: FTR1; cl00475
395961009342	Ferritin-like domain; Region: Ferritin; pfam00210
395961009343	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
395961009344	dinuclear metal binding motif [ion binding]; other site
395961009345	Uncharacterized conserved protein [Function unknown]; Region: COG1434
395961009346	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
395961009347	putative active site [active]
395961009348	Domain of unknown function (DUF1817); Region: DUF1817; pfam08847
395961009349	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
395961009350	MoaE interaction surface [polypeptide binding]; other site
395961009351	MoeB interaction surface [polypeptide binding]; other site
395961009352	thiocarboxylated glycine; other site
395961009353	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
395961009354	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
395961009355	Active Sites [active]
395961009356	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
395961009357	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
395961009358	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
395961009359	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
395961009360	Uncharacterized conserved protein [Function unknown]; Region: COG1432
395961009361	LabA_like proteins; Region: LabA; cd10911
395961009362	putative metal binding site [ion binding]; other site
395961009363	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
395961009364	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
395961009365	active site
395961009366	HIGH motif; other site
395961009367	KMSKS motif; other site
395961009368	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
395961009369	anticodon binding site; other site
395961009370	tRNA binding surface [nucleotide binding]; other site
395961009371	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395961009372	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395961009373	putative acyl-acceptor binding pocket; other site
395961009374	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395961009375	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
395961009376	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
395961009377	Pantoate-beta-alanine ligase; Region: PanC; cd00560
395961009378	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
395961009379	active site
395961009380	ATP-binding site [chemical binding]; other site
395961009381	pantoate-binding site; other site
395961009382	HXXH motif; other site
395961009383	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
395961009384	CMP-binding site; other site
395961009385	The sites determining sugar specificity; other site
395961009386	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
395961009387	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
395961009388	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
395961009389	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
395961009390	dimerization interface [polypeptide binding]; other site
395961009391	putative ATP binding site [chemical binding]; other site
395961009392	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
395961009393	active site
395961009394	catalytic residues [active]
395961009395	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
395961009396	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
395961009397	ligand-binding site [chemical binding]; other site
395961009398	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
395961009399	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395961009400	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395961009401	catalytic residue [active]
395961009402	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
395961009403	RNase_H superfamily; Region: RNase_H_2; pfam13482
395961009404	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
395961009405	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
395961009406	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395961009407	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961009408	active site
395961009409	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395961009410	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961009411	Walker A/P-loop; other site
395961009412	ATP binding site [chemical binding]; other site
395961009413	Q-loop/lid; other site
395961009414	ABC transporter signature motif; other site
395961009415	Walker B; other site
395961009416	D-loop; other site
395961009417	H-loop/switch region; other site
395961009418	TPR repeat; Region: TPR_11; pfam13414
395961009419	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961009420	binding surface
395961009421	TPR motif; other site
395961009422	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961009423	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961009424	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961009425	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961009426	active site
395961009427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961009428	dimer interface [polypeptide binding]; other site
395961009429	conserved gate region; other site
395961009430	putative PBP binding loops; other site
395961009431	ABC-ATPase subunit interface; other site
395961009432	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395961009433	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395961009434	substrate binding pocket [chemical binding]; other site
395961009435	membrane-bound complex binding site; other site
395961009436	hinge residues; other site
395961009437	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
395961009438	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
395961009439	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
395961009440	triosephosphate isomerase; Provisional; Region: PRK14565
395961009441	dimer interface [polypeptide binding]; other site
395961009442	substrate binding site [chemical binding]; other site
395961009443	catalytic triad [active]
395961009444	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
395961009445	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961009446	motif II; other site
395961009447	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
395961009448	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
395961009449	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
395961009450	ligand binding site [chemical binding]; other site
395961009451	NAD binding site [chemical binding]; other site
395961009452	dimerization interface [polypeptide binding]; other site
395961009453	catalytic site [active]
395961009454	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
395961009455	putative L-serine binding site [chemical binding]; other site
395961009456	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
395961009457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961009458	S-adenosylmethionine binding site [chemical binding]; other site
395961009459	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
395961009460	V-type ATP synthase subunit I; Validated; Region: PRK05771
395961009461	Immunoglobulin domain; Region: Ig; cl11960
395961009462	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
395961009463	NADPH bind site [chemical binding]; other site
395961009464	putative FMN binding site [chemical binding]; other site
395961009465	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
395961009466	putative FMN binding site [chemical binding]; other site
395961009467	NADPH bind site [chemical binding]; other site
395961009468	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961009469	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961009470	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961009471	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
395961009472	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
395961009473	Type II transport protein GspH; Region: GspH; pfam12019
395961009474	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
395961009475	Protein of unknown function DUF58; Region: DUF58; pfam01882
395961009476	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
395961009477	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
395961009478	Cysteine-rich domain; Region: CCG; pfam02754
395961009479	Cysteine-rich domain; Region: CCG; pfam02754
395961009480	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
395961009481	FAD binding domain; Region: FAD_binding_4; pfam01565
395961009482	Membrane protein of unknown function; Region: DUF360; pfam04020
395961009483	BON domain; Region: BON; cl02771
395961009484	heat shock protein HtpX; Provisional; Region: PRK03982
395961009485	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
395961009486	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
395961009487	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
395961009488	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
395961009489	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
395961009490	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395961009491	DXD motif; other site
395961009492	Cellulose synthase-like protein; Region: PLN02893
395961009493	PilZ domain; Region: PilZ; pfam07238
395961009494	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
395961009495	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
395961009496	nucleophilic elbow; other site
395961009497	catalytic triad; other site
395961009498	Protein of unknown function, DUF393; Region: DUF393; pfam04134
395961009499	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
395961009500	CAAX protease self-immunity; Region: Abi; pfam02517
395961009501	cobalamin synthase; Reviewed; Region: cobS; PRK00235
395961009502	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
395961009503	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
395961009504	homodimer interface [polypeptide binding]; other site
395961009505	oligonucleotide binding site [chemical binding]; other site
395961009506	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
395961009507	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
395961009508	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
395961009509	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961009510	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961009511	S-adenosylmethionine binding site [chemical binding]; other site
395961009512	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395961009513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961009514	active site
395961009515	phosphorylation site [posttranslational modification]
395961009516	intermolecular recognition site; other site
395961009517	dimerization interface [polypeptide binding]; other site
395961009518	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395961009519	DNA binding site [nucleotide binding]
395961009520	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395961009521	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395961009522	putative acyl-acceptor binding pocket; other site
395961009523	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
395961009524	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961009525	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961009526	S-adenosylmethionine binding site [chemical binding]; other site
395961009527	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395961009528	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
395961009529	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395961009530	catalytic residue [active]
395961009531	Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695
395961009532	Uncharacterized conserved protein [Function unknown]; Region: COG2006
395961009533	Domain of unknown function (DUF362); Region: DUF362; pfam04015
395961009534	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
395961009535	multimerization interface [polypeptide binding]; other site
395961009536	RbcX protein; Region: RcbX; pfam02341
395961009537	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
395961009538	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
395961009539	homodimer interface [polypeptide binding]; other site
395961009540	active site
395961009541	heterodimer interface [polypeptide binding]; other site
395961009542	catalytic residue [active]
395961009543	metal binding site [ion binding]; metal-binding site
395961009544	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
395961009545	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
395961009546	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961009547	putative active site [active]
395961009548	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
395961009549	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
395961009550	MOSC domain; Region: MOSC; pfam03473
395961009551	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
395961009552	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395961009553	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
395961009554	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
395961009555	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
395961009556	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
395961009557	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
395961009558	putative active site [active]
395961009559	transaldolase; Provisional; Region: PRK03903
395961009560	catalytic residue [active]
395961009561	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
395961009562	AMP binding site [chemical binding]; other site
395961009563	metal binding site [ion binding]; metal-binding site
395961009564	active site
395961009565	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
395961009566	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
395961009567	PemK-like protein; Region: PemK; pfam02452
395961009568	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
395961009569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961009570	putative substrate translocation pore; other site
395961009571	Transmembrane proteins 14C; Region: Tmemb_14; cl02346
395961009572	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
395961009573	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961009574	FeS/SAM binding site; other site
395961009575	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
395961009576	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
395961009577	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
395961009578	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
395961009579	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395961009580	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961009581	NAD(P) binding site [chemical binding]; other site
395961009582	active site
395961009583	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333
395961009584	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
395961009585	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
395961009586	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
395961009587	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395961009588	catalytic residue [active]
395961009589	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
395961009590	FeS assembly protein SufD; Region: sufD; TIGR01981
395961009591	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
395961009592	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
395961009593	Walker A/P-loop; other site
395961009594	ATP binding site [chemical binding]; other site
395961009595	Q-loop/lid; other site
395961009596	ABC transporter signature motif; other site
395961009597	Walker B; other site
395961009598	D-loop; other site
395961009599	H-loop/switch region; other site
395961009600	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
395961009601	Methyltransferase domain; Region: Methyltransf_25; pfam13649
395961009602	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961009603	putative active site [active]
395961009604	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
395961009605	putative ABC transporter; Region: ycf24; CHL00085
395961009606	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
395961009607	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395961009608	putative DNA binding site [nucleotide binding]; other site
395961009609	putative Zn2+ binding site [ion binding]; other site
395961009610	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
395961009611	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
395961009612	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961009613	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961009614	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
395961009615	putative active site [active]
395961009616	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
395961009617	putative acetyltransferase; Provisional; Region: PRK03624
395961009618	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961009619	Coenzyme A binding pocket [chemical binding]; other site
395961009620	Cupin domain; Region: Cupin_2; cl17218
395961009621	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
395961009622	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
395961009623	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961009624	Ligand Binding Site [chemical binding]; other site
395961009625	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961009626	Ligand Binding Site [chemical binding]; other site
395961009627	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
395961009628	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
395961009629	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395961009630	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395961009631	active site
395961009632	catalytic tetrad [active]
395961009633	CsbD-like; Region: CsbD; pfam05532
395961009634	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
395961009635	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
395961009636	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
395961009637	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
395961009638	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
395961009639	short chain dehydrogenase; Provisional; Region: PRK06701
395961009640	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
395961009641	NAD binding site [chemical binding]; other site
395961009642	metal binding site [ion binding]; metal-binding site
395961009643	active site
395961009644	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
395961009645	AAA ATPase domain; Region: AAA_16; pfam13191
395961009646	NACHT domain; Region: NACHT; pfam05729
395961009647	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395961009648	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961009649	structural tetrad; other site
395961009650	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961009651	structural tetrad; other site
395961009652	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
395961009653	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961009654	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961009655	active site
395961009656	phosphorylation site [posttranslational modification]
395961009657	intermolecular recognition site; other site
395961009658	dimerization interface [polypeptide binding]; other site
395961009659	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
395961009660	active site
395961009661	catalytic residues [active]
395961009662	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395961009663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961009664	dimer interface [polypeptide binding]; other site
395961009665	conserved gate region; other site
395961009666	putative PBP binding loops; other site
395961009667	ABC-ATPase subunit interface; other site
395961009668	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961009669	putative active site [active]
395961009670	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
395961009671	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
395961009672	S-adenosylmethionine binding site [chemical binding]; other site
395961009673	enolase; Provisional; Region: eno; PRK00077
395961009674	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
395961009675	dimer interface [polypeptide binding]; other site
395961009676	metal binding site [ion binding]; metal-binding site
395961009677	substrate binding pocket [chemical binding]; other site
395961009678	Bacterial SH3 domain; Region: SH3_3; cl17532
395961009679	Ycf46; Provisional; Region: ycf46; CHL00195
395961009680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961009681	Walker A motif; other site
395961009682	ATP binding site [chemical binding]; other site
395961009683	Walker B motif; other site
395961009684	arginine finger; other site
395961009685	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
395961009686	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
395961009687	Probable transposase; Region: OrfB_IS605; pfam01385
395961009688	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
395961009689	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
395961009690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961009691	S-adenosylmethionine binding site [chemical binding]; other site
395961009692	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
395961009693	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395961009694	Cache domain; Region: Cache_1; pfam02743
395961009695	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961009696	dimerization interface [polypeptide binding]; other site
395961009697	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961009698	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961009699	metal binding site [ion binding]; metal-binding site
395961009700	active site
395961009701	I-site; other site
395961009702	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961009703	Cytochrome c; Region: Cytochrom_C; cl11414
395961009704	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395961009705	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
395961009706	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
395961009707	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
395961009708	Protein of unknown function (DUF790); Region: DUF790; pfam05626
395961009709	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
395961009710	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
395961009711	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
395961009712	tRNA; other site
395961009713	putative tRNA binding site [nucleotide binding]; other site
395961009714	putative NADP binding site [chemical binding]; other site
395961009715	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
395961009716	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
395961009717	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
395961009718	putative active site [active]
395961009719	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
395961009720	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
395961009721	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
395961009722	substrate binding pocket [chemical binding]; other site
395961009723	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
395961009724	B12 binding site [chemical binding]; other site
395961009725	cobalt ligand [ion binding]; other site
395961009726	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
395961009727	CHASE4 domain; Region: CHASE4; pfam05228
395961009728	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961009729	Histidine kinase; Region: HisKA_2; pfam07568
395961009730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961009731	ATP binding site [chemical binding]; other site
395961009732	Mg2+ binding site [ion binding]; other site
395961009733	G-X-G motif; other site
395961009734	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395961009735	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395961009736	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
395961009737	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961009738	ABC-ATPase subunit interface; other site
395961009739	putative PBP binding loops; other site
395961009740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961009741	dimer interface [polypeptide binding]; other site
395961009742	conserved gate region; other site
395961009743	putative PBP binding loops; other site
395961009744	ABC-ATPase subunit interface; other site
395961009745	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395961009746	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961009747	Walker A/P-loop; other site
395961009748	ATP binding site [chemical binding]; other site
395961009749	Q-loop/lid; other site
395961009750	ABC transporter signature motif; other site
395961009751	Walker B; other site
395961009752	D-loop; other site
395961009753	H-loop/switch region; other site
395961009754	TOBE domain; Region: TOBE_2; pfam08402
395961009755	Predicted membrane protein [Function unknown]; Region: COG1808
395961009756	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
395961009757	Domain of unknown function DUF21; Region: DUF21; pfam01595
395961009758	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
395961009759	Transporter associated domain; Region: CorC_HlyC; smart01091
395961009760	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
395961009761	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
395961009762	twin arginine translocase protein A; Provisional; Region: tatA; PRK14857
395961009763	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
395961009764	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
395961009765	putative active site [active]
395961009766	catalytic residue [active]
395961009767	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
395961009768	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
395961009769	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
395961009770	shikimate kinase; Reviewed; Region: aroK; PRK00131
395961009771	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
395961009772	ADP binding site [chemical binding]; other site
395961009773	magnesium binding site [ion binding]; other site
395961009774	putative shikimate binding site; other site
395961009775	aromatic acid decarboxylase; Validated; Region: PRK05920
395961009776	Flavoprotein; Region: Flavoprotein; pfam02441
395961009777	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961009778	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961009779	phosphopeptide binding site; other site
395961009780	Transglycosylase; Region: Transgly; pfam00912
395961009781	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
395961009782	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
395961009783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
395961009784	MORN repeat; Region: MORN; cl14787
395961009785	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395961009786	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395961009787	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
395961009788	catalytic site [active]
395961009789	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961009790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961009791	active site
395961009792	phosphorylation site [posttranslational modification]
395961009793	intermolecular recognition site; other site
395961009794	dimerization interface [polypeptide binding]; other site
395961009795	PAS fold; Region: PAS_4; pfam08448
395961009796	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961009797	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961009798	metal binding site [ion binding]; metal-binding site
395961009799	active site
395961009800	I-site; other site
395961009801	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961009802	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
395961009803	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395961009804	Walker A/P-loop; other site
395961009805	ATP binding site [chemical binding]; other site
395961009806	Q-loop/lid; other site
395961009807	ABC transporter signature motif; other site
395961009808	Walker B; other site
395961009809	D-loop; other site
395961009810	H-loop/switch region; other site
395961009811	TOBE domain; Region: TOBE_2; pfam08402
395961009812	Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320
395961009813	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961009814	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
395961009815	putative metal binding site; other site
395961009816	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395961009817	TPR motif; other site
395961009818	binding surface
395961009819	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961009820	binding surface
395961009821	TPR repeat; Region: TPR_11; pfam13414
395961009822	TPR motif; other site
395961009823	TPR repeat; Region: TPR_11; pfam13414
395961009824	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
395961009825	AAA domain; Region: AAA_23; pfam13476
395961009826	Walker A/P-loop; other site
395961009827	ATP binding site [chemical binding]; other site
395961009828	Q-loop/lid; other site
395961009829	exonuclease SbcC; Region: sbcc; TIGR00618
395961009830	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961009831	ABC transporter signature motif; other site
395961009832	Walker B; other site
395961009833	D-loop; other site
395961009834	H-loop/switch region; other site
395961009835	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
395961009836	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
395961009837	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395961009838	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
395961009839	hypothetical protein; Provisional; Region: PRK07377
395961009840	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
395961009841	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
395961009842	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
395961009843	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
395961009844	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
395961009845	Cache domain; Region: Cache_1; pfam02743
395961009846	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961009847	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961009848	dimer interface [polypeptide binding]; other site
395961009849	phosphorylation site [posttranslational modification]
395961009850	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961009851	ATP binding site [chemical binding]; other site
395961009852	Mg2+ binding site [ion binding]; other site
395961009853	G-X-G motif; other site
395961009854	Response regulator receiver domain; Region: Response_reg; pfam00072
395961009855	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961009856	active site
395961009857	phosphorylation site [posttranslational modification]
395961009858	intermolecular recognition site; other site
395961009859	dimerization interface [polypeptide binding]; other site
395961009860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961009861	active site
395961009862	phosphorylation site [posttranslational modification]
395961009863	intermolecular recognition site; other site
395961009864	dimerization interface [polypeptide binding]; other site
395961009865	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
395961009866	active site
395961009867	dimer interface [polypeptide binding]; other site
395961009868	metal binding site [ion binding]; metal-binding site
395961009869	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
395961009870	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961009871	putative substrate translocation pore; other site
395961009872	dihydrodipicolinate reductase; Provisional; Region: PRK00048
395961009873	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
395961009874	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
395961009875	CHASE4 domain; Region: CHASE4; pfam05228
395961009876	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009877	PAS fold; Region: PAS_3; pfam08447
395961009878	putative active site [active]
395961009879	heme pocket [chemical binding]; other site
395961009880	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961009881	metal binding site [ion binding]; metal-binding site
395961009882	active site
395961009883	I-site; other site
395961009884	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961009885	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961009886	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961009887	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961009888	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961009889	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
395961009890	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
395961009891	putative active site [active]
395961009892	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
395961009893	putative active site [active]
395961009894	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
395961009895	active site
395961009896	SAM binding site [chemical binding]; other site
395961009897	homodimer interface [polypeptide binding]; other site
395961009898	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395961009899	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961009900	dimer interface [polypeptide binding]; other site
395961009901	conserved gate region; other site
395961009902	putative PBP binding loops; other site
395961009903	ABC-ATPase subunit interface; other site
395961009904	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009905	PAS domain; Region: PAS_9; pfam13426
395961009906	putative active site [active]
395961009907	heme pocket [chemical binding]; other site
395961009908	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961009909	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961009910	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009911	PAS fold; Region: PAS_3; pfam08447
395961009912	putative active site [active]
395961009913	heme pocket [chemical binding]; other site
395961009914	PAS domain S-box; Region: sensory_box; TIGR00229
395961009915	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009916	putative active site [active]
395961009917	heme pocket [chemical binding]; other site
395961009918	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961009919	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961009920	metal binding site [ion binding]; metal-binding site
395961009921	active site
395961009922	I-site; other site
395961009923	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961009924	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961009925	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961009926	phosphopeptide binding site; other site
395961009927	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
395961009928	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
395961009929	Probable Catalytic site; other site
395961009930	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
395961009931	Protein of unknown function, DUF482; Region: DUF482; pfam04339
395961009932	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
395961009933	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961009934	Walker A/P-loop; other site
395961009935	ATP binding site [chemical binding]; other site
395961009936	Q-loop/lid; other site
395961009937	ABC transporter signature motif; other site
395961009938	Walker B; other site
395961009939	D-loop; other site
395961009940	H-loop/switch region; other site
395961009941	Protein of unknown function (DUF433); Region: DUF433; cl01030
395961009942	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
395961009943	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
395961009944	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961009945	GAF domain; Region: GAF; pfam01590
395961009946	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961009947	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961009948	dimer interface [polypeptide binding]; other site
395961009949	phosphorylation site [posttranslational modification]
395961009950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961009951	ATP binding site [chemical binding]; other site
395961009952	Mg2+ binding site [ion binding]; other site
395961009953	G-X-G motif; other site
395961009954	arogenate dehydrogenase; Reviewed; Region: PRK07417
395961009955	prephenate dehydrogenase; Validated; Region: PRK08507
395961009956	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
395961009957	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
395961009958	Active site cavity [active]
395961009959	catalytic acid [active]
395961009960	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961009961	Walker A/P-loop; other site
395961009962	ATP binding site [chemical binding]; other site
395961009963	AAA domain; Region: AAA_21; pfam13304
395961009964	FOG: CBS domain [General function prediction only]; Region: COG0517
395961009965	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395961009966	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009967	PAS fold; Region: PAS_3; pfam08447
395961009968	putative active site [active]
395961009969	heme pocket [chemical binding]; other site
395961009970	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961009971	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009972	putative active site [active]
395961009973	heme pocket [chemical binding]; other site
395961009974	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009975	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961009976	putative active site [active]
395961009977	heme pocket [chemical binding]; other site
395961009978	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
395961009979	putative active site [active]
395961009980	heme pocket [chemical binding]; other site
395961009981	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961009982	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009983	heme pocket [chemical binding]; other site
395961009984	putative active site [active]
395961009985	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009986	putative active site [active]
395961009987	heme pocket [chemical binding]; other site
395961009988	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961009989	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395961009990	putative active site [active]
395961009991	heme pocket [chemical binding]; other site
395961009992	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961009993	dimer interface [polypeptide binding]; other site
395961009994	phosphorylation site [posttranslational modification]
395961009995	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961009996	ATP binding site [chemical binding]; other site
395961009997	Mg2+ binding site [ion binding]; other site
395961009998	G-X-G motif; other site
395961009999	Response regulator receiver domain; Region: Response_reg; pfam00072
395961010000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010001	active site
395961010002	phosphorylation site [posttranslational modification]
395961010003	intermolecular recognition site; other site
395961010004	dimerization interface [polypeptide binding]; other site
395961010005	FOG: CBS domain [General function prediction only]; Region: COG0517
395961010006	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395961010007	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961010008	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010009	putative active site [active]
395961010010	heme pocket [chemical binding]; other site
395961010011	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010012	putative active site [active]
395961010013	heme pocket [chemical binding]; other site
395961010014	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010015	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961010016	putative active site [active]
395961010017	heme pocket [chemical binding]; other site
395961010018	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961010019	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010020	putative active site [active]
395961010021	heme pocket [chemical binding]; other site
395961010022	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010023	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961010024	putative active site [active]
395961010025	heme pocket [chemical binding]; other site
395961010026	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010027	putative active site [active]
395961010028	heme pocket [chemical binding]; other site
395961010029	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395961010030	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010031	putative active site [active]
395961010032	heme pocket [chemical binding]; other site
395961010033	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961010034	dimer interface [polypeptide binding]; other site
395961010035	phosphorylation site [posttranslational modification]
395961010036	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961010037	ATP binding site [chemical binding]; other site
395961010038	Mg2+ binding site [ion binding]; other site
395961010039	G-X-G motif; other site
395961010040	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961010041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010042	active site
395961010043	phosphorylation site [posttranslational modification]
395961010044	intermolecular recognition site; other site
395961010045	dimerization interface [polypeptide binding]; other site
395961010046	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
395961010047	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
395961010048	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395961010049	binding surface
395961010050	TPR motif; other site
395961010051	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961010052	TPR motif; other site
395961010053	binding surface
395961010054	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961010055	binding surface
395961010056	TPR motif; other site
395961010057	TPR repeat; Region: TPR_11; pfam13414
395961010058	High-affinity nickel-transport protein; Region: NicO; cl00964
395961010059	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
395961010060	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
395961010061	homotetramer interface [polypeptide binding]; other site
395961010062	FMN binding site [chemical binding]; other site
395961010063	homodimer contacts [polypeptide binding]; other site
395961010064	putative active site [active]
395961010065	putative substrate binding site [chemical binding]; other site
395961010066	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
395961010067	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
395961010068	dimerization interface [polypeptide binding]; other site
395961010069	ATP binding site [chemical binding]; other site
395961010070	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
395961010071	dimerization interface [polypeptide binding]; other site
395961010072	ATP binding site [chemical binding]; other site
395961010073	amidophosphoribosyltransferase; Provisional; Region: PRK07349
395961010074	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
395961010075	active site
395961010076	tetramer interface [polypeptide binding]; other site
395961010077	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395961010078	active site
395961010079	cell division protein; Validated; Region: ftsH; CHL00176
395961010080	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961010081	Walker A motif; other site
395961010082	ATP binding site [chemical binding]; other site
395961010083	Walker B motif; other site
395961010084	arginine finger; other site
395961010085	Peptidase family M41; Region: Peptidase_M41; pfam01434
395961010086	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395961010087	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395961010088	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395961010089	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961010090	putative active site [active]
395961010091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
395961010092	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
395961010093	Uncharacterized conserved protein [Function unknown]; Region: COG2308
395961010094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
395961010095	MOSC domain; Region: MOSC; pfam03473
395961010096	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
395961010097	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395961010098	active site
395961010099	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395961010100	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395961010101	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395961010102	protein binding site [polypeptide binding]; other site
395961010103	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395961010104	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395961010105	catalytic residue [active]
395961010106	aspartate aminotransferase; Provisional; Region: PRK05942
395961010107	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395961010108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961010109	homodimer interface [polypeptide binding]; other site
395961010110	catalytic residue [active]
395961010111	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
395961010112	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
395961010113	putative active site [active]
395961010114	metal binding site [ion binding]; metal-binding site
395961010115	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
395961010116	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
395961010117	Cupin domain; Region: Cupin_2; pfam07883
395961010118	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
395961010119	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395961010120	active site
395961010121	catalytic tetrad [active]
395961010122	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
395961010123	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961010124	TPR motif; other site
395961010125	binding surface
395961010126	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961010127	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961010128	S-adenosylmethionine binding site [chemical binding]; other site
395961010129	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
395961010130	active site clefts [active]
395961010131	zinc binding site [ion binding]; other site
395961010132	dimer interface [polypeptide binding]; other site
395961010133	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
395961010134	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
395961010135	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
395961010136	Substrate binding site; other site
395961010137	Cupin domain; Region: Cupin_2; cl17218
395961010138	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961010139	putative active site [active]
395961010140	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
395961010141	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
395961010142	FMN binding site [chemical binding]; other site
395961010143	active site
395961010144	catalytic residues [active]
395961010145	substrate binding site [chemical binding]; other site
395961010146	Response regulator receiver domain; Region: Response_reg; pfam00072
395961010147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010148	active site
395961010149	phosphorylation site [posttranslational modification]
395961010150	intermolecular recognition site; other site
395961010151	dimerization interface [polypeptide binding]; other site
395961010152	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961010153	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961010154	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010155	PAS fold; Region: PAS_3; pfam08447
395961010156	putative active site [active]
395961010157	heme pocket [chemical binding]; other site
395961010158	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010159	PAS fold; Region: PAS_3; pfam08447
395961010160	putative active site [active]
395961010161	heme pocket [chemical binding]; other site
395961010162	PAS domain S-box; Region: sensory_box; TIGR00229
395961010163	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010164	PAS fold; Region: PAS_3; pfam08447
395961010165	putative active site [active]
395961010166	heme pocket [chemical binding]; other site
395961010167	PAS domain; Region: PAS_9; pfam13426
395961010168	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961010169	GAF domain; Region: GAF; pfam01590
395961010170	PAS fold; Region: PAS_4; pfam08448
395961010171	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010172	PAS domain; Region: PAS_9; pfam13426
395961010173	putative active site [active]
395961010174	heme pocket [chemical binding]; other site
395961010175	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961010176	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961010177	dimer interface [polypeptide binding]; other site
395961010178	phosphorylation site [posttranslational modification]
395961010179	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961010180	ATP binding site [chemical binding]; other site
395961010181	Mg2+ binding site [ion binding]; other site
395961010182	G-X-G motif; other site
395961010183	Response regulator receiver domain; Region: Response_reg; pfam00072
395961010184	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010185	active site
395961010186	phosphorylation site [posttranslational modification]
395961010187	intermolecular recognition site; other site
395961010188	dimerization interface [polypeptide binding]; other site
395961010189	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
395961010190	putative active site [active]
395961010191	heme pocket [chemical binding]; other site
395961010192	HEAT repeats; Region: HEAT_2; pfam13646
395961010193	Uncharacterized conserved protein [Function unknown]; Region: COG2006
395961010194	Domain of unknown function (DUF362); Region: DUF362; pfam04015
395961010195	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
395961010196	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961010197	motif II; other site
395961010198	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395961010199	hypothetical protein; Provisional; Region: PRK10621
395961010200	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
395961010201	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395961010202	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961010203	dimer interface [polypeptide binding]; other site
395961010204	conserved gate region; other site
395961010205	putative PBP binding loops; other site
395961010206	ABC-ATPase subunit interface; other site
395961010207	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
395961010208	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961010209	Walker A/P-loop; other site
395961010210	ATP binding site [chemical binding]; other site
395961010211	Q-loop/lid; other site
395961010212	ABC transporter signature motif; other site
395961010213	Walker B; other site
395961010214	D-loop; other site
395961010215	H-loop/switch region; other site
395961010216	TOBE domain; Region: TOBE_2; pfam08402
395961010217	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395961010218	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395961010219	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395961010220	Outer membrane efflux protein; Region: OEP; pfam02321
395961010221	Outer membrane efflux protein; Region: OEP; pfam02321
395961010222	Outer membrane efflux protein; Region: OEP; pfam02321
395961010223	LytB protein; Region: LYTB; cl00507
395961010224	Outer membrane efflux protein; Region: OEP; pfam02321
395961010225	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395961010226	active site
395961010227	metal binding site [ion binding]; metal-binding site
395961010228	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395961010229	putative lipid kinase; Reviewed; Region: PRK00861
395961010230	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
395961010231	Predicted dehydrogenase [General function prediction only]; Region: COG0579
395961010232	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
395961010233	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
395961010234	Ion channel; Region: Ion_trans_2; pfam07885
395961010235	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
395961010236	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
395961010237	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
395961010238	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395961010239	substrate binding pocket [chemical binding]; other site
395961010240	membrane-bound complex binding site; other site
395961010241	hinge residues; other site
395961010242	rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260
395961010243	radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261
395961010244	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961010245	FeS/SAM binding site; other site
395961010246	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
395961010247	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
395961010248	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395961010249	substrate binding pocket [chemical binding]; other site
395961010250	membrane-bound complex binding site; other site
395961010251	hinge residues; other site
395961010252	radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261
395961010253	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961010254	FeS/SAM binding site; other site
395961010255	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
395961010256	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
395961010257	RNA binding site [nucleotide binding]; other site
395961010258	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
395961010259	RNA binding site [nucleotide binding]; other site
395961010260	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
395961010261	RNA binding site [nucleotide binding]; other site
395961010262	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395961010263	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395961010264	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
395961010265	metal ion-dependent adhesion site (MIDAS); other site
395961010266	TPR repeat; Region: TPR_11; pfam13414
395961010267	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395961010268	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395961010269	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961010270	TPR repeat; Region: TPR_11; pfam13414
395961010271	TPR motif; other site
395961010272	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961010273	putative active site [active]
395961010274	S-layer homology domain; Region: SLH; pfam00395
395961010275	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
395961010276	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
395961010277	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
395961010278	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
395961010279	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
395961010280	C-terminal peptidase (prc); Region: prc; TIGR00225
395961010281	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
395961010282	protein binding site [polypeptide binding]; other site
395961010283	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
395961010284	Catalytic dyad [active]
395961010285	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
395961010286	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
395961010287	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
395961010288	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
395961010289	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
395961010290	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395961010291	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395961010292	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395961010293	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
395961010294	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
395961010295	trmE is a tRNA modification GTPase; Region: trmE; cd04164
395961010296	G1 box; other site
395961010297	GTP/Mg2+ binding site [chemical binding]; other site
395961010298	Switch I region; other site
395961010299	G2 box; other site
395961010300	Switch II region; other site
395961010301	G3 box; other site
395961010302	G4 box; other site
395961010303	G5 box; other site
395961010304	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
395961010305	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
395961010306	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
395961010307	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
395961010308	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961010309	ATP binding site [chemical binding]; other site
395961010310	putative Mg++ binding site [ion binding]; other site
395961010311	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
395961010312	Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229
395961010313	Response regulator receiver domain; Region: Response_reg; pfam00072
395961010314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010315	active site
395961010316	phosphorylation site [posttranslational modification]
395961010317	intermolecular recognition site; other site
395961010318	dimerization interface [polypeptide binding]; other site
395961010319	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961010320	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961010321	phosphopeptide binding site; other site
395961010322	PAS domain S-box; Region: sensory_box; TIGR00229
395961010323	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010324	PAS fold; Region: PAS_3; pfam08447
395961010325	putative active site [active]
395961010326	heme pocket [chemical binding]; other site
395961010327	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961010328	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961010329	metal binding site [ion binding]; metal-binding site
395961010330	active site
395961010331	I-site; other site
395961010332	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961010333	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
395961010334	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
395961010335	active site
395961010336	catalytic site [active]
395961010337	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
395961010338	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
395961010339	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
395961010340	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
395961010341	PetN; Region: PetN; pfam03742
395961010342	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
395961010343	arginine-tRNA ligase; Region: PLN02286
395961010344	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
395961010345	active site
395961010346	HIGH motif; other site
395961010347	KMSK motif region; other site
395961010348	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
395961010349	tRNA binding surface [nucleotide binding]; other site
395961010350	anticodon binding site; other site
395961010351	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395961010352	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395961010353	protein binding site [polypeptide binding]; other site
395961010354	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961010355	S-adenosylmethionine binding site [chemical binding]; other site
395961010356	Predicted membrane protein [Function unknown]; Region: COG1289
395961010357	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
395961010358	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
395961010359	Predicted transcriptional regulators [Transcription]; Region: COG1733
395961010360	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395961010361	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961010362	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961010363	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
395961010364	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
395961010365	FMN binding site [chemical binding]; other site
395961010366	active site
395961010367	substrate binding site [chemical binding]; other site
395961010368	catalytic residue [active]
395961010369	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
395961010370	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395961010371	Coenzyme A binding pocket [chemical binding]; other site
395961010372	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
395961010373	apolar tunnel; other site
395961010374	heme binding site [chemical binding]; other site
395961010375	dimerization interface [polypeptide binding]; other site
395961010376	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
395961010377	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
395961010378	Uncharacterized conserved protein [Function unknown]; Region: COG1359
395961010379	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395961010380	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
395961010381	substrate binding site [chemical binding]; other site
395961010382	ATP binding site [chemical binding]; other site
395961010383	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395961010384	Beta-lactamase; Region: Beta-lactamase; pfam00144
395961010385	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395961010386	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
395961010387	putative acyl-acceptor binding pocket; other site
395961010388	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961010389	transposase; Validated; Region: PRK08181
395961010390	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961010391	Walker A motif; other site
395961010392	ATP binding site [chemical binding]; other site
395961010393	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395961010394	binding surface
395961010395	TPR motif; other site
395961010396	TPR repeat; Region: TPR_11; pfam13414
395961010397	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961010398	binding surface
395961010399	TPR motif; other site
395961010400	TPR repeat; Region: TPR_11; pfam13414
395961010401	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961010402	binding surface
395961010403	TPR motif; other site
395961010404	TPR repeat; Region: TPR_11; pfam13414
395961010405	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961010406	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961010407	S-adenosylmethionine binding site [chemical binding]; other site
395961010408	Cache domain; Region: Cache_1; pfam02743
395961010409	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961010410	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961010411	dimerization interface [polypeptide binding]; other site
395961010412	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961010413	dimer interface [polypeptide binding]; other site
395961010414	phosphorylation site [posttranslational modification]
395961010415	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961010416	ATP binding site [chemical binding]; other site
395961010417	Mg2+ binding site [ion binding]; other site
395961010418	G-X-G motif; other site
395961010419	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961010420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010421	active site
395961010422	phosphorylation site [posttranslational modification]
395961010423	intermolecular recognition site; other site
395961010424	dimerization interface [polypeptide binding]; other site
395961010425	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961010426	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010427	active site
395961010428	phosphorylation site [posttranslational modification]
395961010429	intermolecular recognition site; other site
395961010430	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
395961010431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961010432	ATP binding site [chemical binding]; other site
395961010433	Mg2+ binding site [ion binding]; other site
395961010434	G-X-G motif; other site
395961010435	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
395961010436	ATP binding site [chemical binding]; other site
395961010437	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
395961010438	ScpA/B protein; Region: ScpA_ScpB; cl00598
395961010439	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
395961010440	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
395961010441	SdpI/YhfL protein family; Region: SdpI; pfam13630
395961010442	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395961010443	DevC protein; Region: devC; TIGR01185
395961010444	FtsX-like permease family; Region: FtsX; pfam02687
395961010445	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395961010446	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395961010447	Walker A/P-loop; other site
395961010448	ATP binding site [chemical binding]; other site
395961010449	Q-loop/lid; other site
395961010450	ABC transporter signature motif; other site
395961010451	Walker B; other site
395961010452	D-loop; other site
395961010453	H-loop/switch region; other site
395961010454	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
395961010455	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
395961010456	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
395961010457	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395961010458	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
395961010459	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961010460	motif II; other site
395961010461	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
395961010462	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
395961010463	putative homodimer interface [polypeptide binding]; other site
395961010464	putative homotetramer interface [polypeptide binding]; other site
395961010465	putative allosteric switch controlling residues; other site
395961010466	putative metal binding site [ion binding]; other site
395961010467	putative homodimer-homodimer interface [polypeptide binding]; other site
395961010468	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
395961010469	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
395961010470	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395961010471	catalytic triad [active]
395961010472	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
395961010473	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
395961010474	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961010475	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961010476	active site
395961010477	ATP binding site [chemical binding]; other site
395961010478	substrate binding site [chemical binding]; other site
395961010479	activation loop (A-loop); other site
395961010480	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
395961010481	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
395961010482	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961010483	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961010484	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
395961010485	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
395961010486	putative ADP-binding pocket [chemical binding]; other site
395961010487	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
395961010488	dimer interface [polypeptide binding]; other site
395961010489	active site
395961010490	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395961010491	classical (c) SDRs; Region: SDR_c; cd05233
395961010492	NAD(P) binding site [chemical binding]; other site
395961010493	active site
395961010494	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
395961010495	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961010496	active site
395961010497	motif I; other site
395961010498	motif II; other site
395961010499	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
395961010500	substrate binding site [chemical binding]; other site
395961010501	ATP binding site [chemical binding]; other site
395961010502	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
395961010503	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
395961010504	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
395961010505	putative active site [active]
395961010506	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961010507	active site
395961010508	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961010509	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395961010510	Response regulator receiver domain; Region: Response_reg; pfam00072
395961010511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010512	active site
395961010513	phosphorylation site [posttranslational modification]
395961010514	intermolecular recognition site; other site
395961010515	dimerization interface [polypeptide binding]; other site
395961010516	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010517	PAS fold; Region: PAS_3; pfam08447
395961010518	putative active site [active]
395961010519	heme pocket [chemical binding]; other site
395961010520	PAS domain S-box; Region: sensory_box; TIGR00229
395961010521	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010522	putative active site [active]
395961010523	heme pocket [chemical binding]; other site
395961010524	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961010525	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961010526	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961010527	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961010528	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961010529	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961010530	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961010531	Histidine kinase; Region: HisKA_2; pfam07568
395961010532	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
395961010533	Mg2+ binding site [ion binding]; other site
395961010534	Uncharacterized conserved protein [Function unknown]; Region: COG3349
395961010535	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961010536	hypothetical protein; Provisional; Region: PRK04194
395961010537	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
395961010538	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961010539	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961010540	GAF domain; Region: GAF; pfam01590
395961010541	GAF domain; Region: GAF; pfam01590
395961010542	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961010543	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
395961010544	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
395961010545	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395961010546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010547	active site
395961010548	phosphorylation site [posttranslational modification]
395961010549	intermolecular recognition site; other site
395961010550	dimerization interface [polypeptide binding]; other site
395961010551	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395961010552	DNA binding site [nucleotide binding]
395961010553	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
395961010554	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961010555	ATP binding site [chemical binding]; other site
395961010556	putative Mg++ binding site [ion binding]; other site
395961010557	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961010558	nucleotide binding region [chemical binding]; other site
395961010559	ATP-binding site [chemical binding]; other site
395961010560	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
395961010561	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
395961010562	putative binding surface; other site
395961010563	active site
395961010564	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
395961010565	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
395961010566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961010567	ATP binding site [chemical binding]; other site
395961010568	Mg2+ binding site [ion binding]; other site
395961010569	G-X-G motif; other site
395961010570	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
395961010571	Response regulator receiver domain; Region: Response_reg; pfam00072
395961010572	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010573	active site
395961010574	phosphorylation site [posttranslational modification]
395961010575	intermolecular recognition site; other site
395961010576	dimerization interface [polypeptide binding]; other site
395961010577	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961010578	binding surface
395961010579	TPR repeat; Region: TPR_11; pfam13414
395961010580	TPR motif; other site
395961010581	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961010582	dimerization interface [polypeptide binding]; other site
395961010583	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395961010584	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395961010585	dimer interface [polypeptide binding]; other site
395961010586	putative CheW interface [polypeptide binding]; other site
395961010587	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
395961010588	Response regulator receiver domain; Region: Response_reg; pfam00072
395961010589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010590	active site
395961010591	phosphorylation site [posttranslational modification]
395961010592	intermolecular recognition site; other site
395961010593	dimerization interface [polypeptide binding]; other site
395961010594	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
395961010595	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961010596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010597	active site
395961010598	phosphorylation site [posttranslational modification]
395961010599	intermolecular recognition site; other site
395961010600	dimerization interface [polypeptide binding]; other site
395961010601	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
395961010602	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
395961010603	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395961010604	MraW methylase family; Region: Methyltransf_5; cl17771
395961010605	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
395961010606	Tubulin like; Region: Tubulin_2; pfam13809
395961010607	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
395961010608	CHASE2 domain; Region: CHASE2; pfam05226
395961010609	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395961010610	cyclase homology domain; Region: CHD; cd07302
395961010611	nucleotidyl binding site; other site
395961010612	metal binding site [ion binding]; metal-binding site
395961010613	dimer interface [polypeptide binding]; other site
395961010614	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
395961010615	hydrophobic ligand binding site; other site
395961010616	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
395961010617	putative lipid kinase; Reviewed; Region: PRK13057
395961010618	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
395961010619	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961010620	active site
395961010621	ATP binding site [chemical binding]; other site
395961010622	substrate binding site [chemical binding]; other site
395961010623	activation loop (A-loop); other site
395961010624	Uncharacterized conserved protein [Function unknown]; Region: COG1262
395961010625	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395961010626	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
395961010627	Peptidase family U32; Region: Peptidase_U32; pfam01136
395961010628	Collagenase; Region: DUF3656; pfam12392
395961010629	Peptidase family U32; Region: Peptidase_U32; cl03113
395961010630	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
395961010631	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
395961010632	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
395961010633	Response regulator receiver domain; Region: Response_reg; pfam00072
395961010634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010635	active site
395961010636	phosphorylation site [posttranslational modification]
395961010637	intermolecular recognition site; other site
395961010638	dimerization interface [polypeptide binding]; other site
395961010639	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961010640	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961010641	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010642	PAS domain; Region: PAS_9; pfam13426
395961010643	putative active site [active]
395961010644	heme pocket [chemical binding]; other site
395961010645	PAS domain S-box; Region: sensory_box; TIGR00229
395961010646	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010647	putative active site [active]
395961010648	heme pocket [chemical binding]; other site
395961010649	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961010650	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010651	putative active site [active]
395961010652	heme pocket [chemical binding]; other site
395961010653	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395961010654	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010655	putative active site [active]
395961010656	heme pocket [chemical binding]; other site
395961010657	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961010658	dimer interface [polypeptide binding]; other site
395961010659	phosphorylation site [posttranslational modification]
395961010660	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961010661	ATP binding site [chemical binding]; other site
395961010662	Mg2+ binding site [ion binding]; other site
395961010663	G-X-G motif; other site
395961010664	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961010665	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961010666	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
395961010667	multifunctional aminopeptidase A; Provisional; Region: PRK00913
395961010668	interface (dimer of trimers) [polypeptide binding]; other site
395961010669	Substrate-binding/catalytic site; other site
395961010670	Zn-binding sites [ion binding]; other site
395961010671	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
395961010672	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395961010673	substrate binding pocket [chemical binding]; other site
395961010674	membrane-bound complex binding site; other site
395961010675	hinge residues; other site
395961010676	Response regulator receiver domain; Region: Response_reg; pfam00072
395961010677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010678	active site
395961010679	phosphorylation site [posttranslational modification]
395961010680	intermolecular recognition site; other site
395961010681	dimerization interface [polypeptide binding]; other site
395961010682	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961010683	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961010684	dimer interface [polypeptide binding]; other site
395961010685	phosphorylation site [posttranslational modification]
395961010686	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961010687	ATP binding site [chemical binding]; other site
395961010688	Mg2+ binding site [ion binding]; other site
395961010689	G-X-G motif; other site
395961010690	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961010691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010692	active site
395961010693	phosphorylation site [posttranslational modification]
395961010694	intermolecular recognition site; other site
395961010695	dimerization interface [polypeptide binding]; other site
395961010696	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395961010697	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961010698	dimerization interface [polypeptide binding]; other site
395961010699	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961010700	dimerization interface [polypeptide binding]; other site
395961010701	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395961010702	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961010703	dimerization interface [polypeptide binding]; other site
395961010704	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961010705	dimerization interface [polypeptide binding]; other site
395961010706	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961010707	dimerization interface [polypeptide binding]; other site
395961010708	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395961010709	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961010710	dimerization interface [polypeptide binding]; other site
395961010711	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961010712	dimerization interface [polypeptide binding]; other site
395961010713	HAMP domain; Region: HAMP; pfam00672
395961010714	dimerization interface [polypeptide binding]; other site
395961010715	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961010716	dimerization interface [polypeptide binding]; other site
395961010717	GAF domain; Region: GAF_2; pfam13185
395961010718	GAF domain; Region: GAF; pfam01590
395961010719	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961010720	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961010721	dimer interface [polypeptide binding]; other site
395961010722	phosphorylation site [posttranslational modification]
395961010723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961010724	ATP binding site [chemical binding]; other site
395961010725	Mg2+ binding site [ion binding]; other site
395961010726	G-X-G motif; other site
395961010727	Response regulator receiver domain; Region: Response_reg; pfam00072
395961010728	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010729	active site
395961010730	phosphorylation site [posttranslational modification]
395961010731	intermolecular recognition site; other site
395961010732	dimerization interface [polypeptide binding]; other site
395961010733	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961010734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010735	active site
395961010736	phosphorylation site [posttranslational modification]
395961010737	intermolecular recognition site; other site
395961010738	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961010739	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010740	active site
395961010741	phosphorylation site [posttranslational modification]
395961010742	intermolecular recognition site; other site
395961010743	dimerization interface [polypeptide binding]; other site
395961010744	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010745	PAS domain; Region: PAS_9; pfam13426
395961010746	putative active site [active]
395961010747	heme pocket [chemical binding]; other site
395961010748	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961010749	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961010750	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010751	PAS fold; Region: PAS_3; pfam08447
395961010752	putative active site [active]
395961010753	heme pocket [chemical binding]; other site
395961010754	hypothetical protein; Provisional; Region: PRK13560
395961010755	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010756	putative active site [active]
395961010757	heme pocket [chemical binding]; other site
395961010758	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010759	putative active site [active]
395961010760	heme pocket [chemical binding]; other site
395961010761	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010762	putative active site [active]
395961010763	heme pocket [chemical binding]; other site
395961010764	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010765	putative active site [active]
395961010766	heme pocket [chemical binding]; other site
395961010767	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961010768	dimer interface [polypeptide binding]; other site
395961010769	phosphorylation site [posttranslational modification]
395961010770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961010771	ATP binding site [chemical binding]; other site
395961010772	Mg2+ binding site [ion binding]; other site
395961010773	G-X-G motif; other site
395961010774	Response regulator receiver domain; Region: Response_reg; pfam00072
395961010775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010776	active site
395961010777	phosphorylation site [posttranslational modification]
395961010778	intermolecular recognition site; other site
395961010779	dimerization interface [polypeptide binding]; other site
395961010780	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
395961010781	PAS fold; Region: PAS; pfam00989
395961010782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010783	putative active site [active]
395961010784	heme pocket [chemical binding]; other site
395961010785	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961010786	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961010787	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395961010788	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010789	putative active site [active]
395961010790	heme pocket [chemical binding]; other site
395961010791	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961010792	dimer interface [polypeptide binding]; other site
395961010793	phosphorylation site [posttranslational modification]
395961010794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961010795	ATP binding site [chemical binding]; other site
395961010796	Mg2+ binding site [ion binding]; other site
395961010797	G-X-G motif; other site
395961010798	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961010799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010800	active site
395961010801	phosphorylation site [posttranslational modification]
395961010802	intermolecular recognition site; other site
395961010803	dimerization interface [polypeptide binding]; other site
395961010804	Phytochelatin synthase; Region: Phytochelatin; pfam05023
395961010805	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961010806	non-specific DNA binding site [nucleotide binding]; other site
395961010807	salt bridge; other site
395961010808	sequence-specific DNA binding site [nucleotide binding]; other site
395961010809	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010810	putative active site [active]
395961010811	heme pocket [chemical binding]; other site
395961010812	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
395961010813	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961010814	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
395961010815	Transposase [DNA replication, recombination, and repair]; Region: COG5433
395961010816	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010817	PAS fold; Region: PAS_3; pfam08447
395961010818	putative active site [active]
395961010819	heme pocket [chemical binding]; other site
395961010820	PAS fold; Region: PAS_3; pfam08447
395961010821	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
395961010822	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010823	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961010824	putative active site [active]
395961010825	heme pocket [chemical binding]; other site
395961010826	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010827	putative active site [active]
395961010828	heme pocket [chemical binding]; other site
395961010829	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961010830	PAS fold; Region: PAS_3; pfam08447
395961010831	putative active site [active]
395961010832	heme pocket [chemical binding]; other site
395961010833	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961010834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961010835	dimer interface [polypeptide binding]; other site
395961010836	phosphorylation site [posttranslational modification]
395961010837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961010838	ATP binding site [chemical binding]; other site
395961010839	Mg2+ binding site [ion binding]; other site
395961010840	G-X-G motif; other site
395961010841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961010842	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961010843	active site
395961010844	phosphorylation site [posttranslational modification]
395961010845	intermolecular recognition site; other site
395961010846	dimerization interface [polypeptide binding]; other site
395961010847	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
395961010848	EF-hand domain pair; Region: EF_hand_5; pfam13499
395961010849	Ca2+ binding site [ion binding]; other site
395961010850	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
395961010851	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
395961010852	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
395961010853	Ligand Binding Site [chemical binding]; other site
395961010854	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
395961010855	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
395961010856	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
395961010857	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961010858	Uncharacterized conserved protein [Function unknown]; Region: COG2361
395961010859	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395961010860	active site
395961010861	NTP binding site [chemical binding]; other site
395961010862	metal binding triad [ion binding]; metal-binding site
395961010863	antibiotic binding site [chemical binding]; other site
395961010864	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
395961010865	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
395961010866	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961010867	FeS/SAM binding site; other site
395961010868	TRAM domain; Region: TRAM; pfam01938
395961010869	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
395961010870	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
395961010871	CHASE2 domain; Region: CHASE2; pfam05226
395961010872	Protein kinase domain; Region: Pkinase; pfam00069
395961010873	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961010874	active site
395961010875	ATP binding site [chemical binding]; other site
395961010876	substrate binding site [chemical binding]; other site
395961010877	activation loop (A-loop); other site
395961010878	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
395961010879	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
395961010880	CoA-binding site [chemical binding]; other site
395961010881	ATP-binding [chemical binding]; other site
395961010882	hypothetical protein; Validated; Region: PRK07413
395961010883	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
395961010884	homodimer interface [polypeptide binding]; other site
395961010885	Walker A motif; other site
395961010886	ATP binding site [chemical binding]; other site
395961010887	hydroxycobalamin binding site [chemical binding]; other site
395961010888	Walker B motif; other site
395961010889	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
395961010890	Walker A motif; other site
395961010891	homodimer interface [polypeptide binding]; other site
395961010892	ATP binding site [chemical binding]; other site
395961010893	hydroxycobalamin binding site [chemical binding]; other site
395961010894	Walker B motif; other site
395961010895	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
395961010896	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
395961010897	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395961010898	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
395961010899	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
395961010900	NAD binding site [chemical binding]; other site
395961010901	homodimer interface [polypeptide binding]; other site
395961010902	active site
395961010903	substrate binding site [chemical binding]; other site
395961010904	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
395961010905	Chain length determinant protein; Region: Wzz; pfam02706
395961010906	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
395961010907	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961010908	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
395961010909	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
395961010910	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961010911	Methyltransferase domain; Region: Methyltransf_11; pfam08241
395961010912	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961010913	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961010914	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
395961010915	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961010916	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
395961010917	putative ADP-binding pocket [chemical binding]; other site
395961010918	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395961010919	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
395961010920	putative NAD(P) binding site [chemical binding]; other site
395961010921	active site
395961010922	putative substrate binding site [chemical binding]; other site
395961010923	Uncharacterized conserved protein [Function unknown]; Region: COG1543
395961010924	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
395961010925	active site
395961010926	substrate binding site [chemical binding]; other site
395961010927	catalytic site [active]
395961010928	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
395961010929	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
395961010930	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
395961010931	phosphate binding site [ion binding]; other site
395961010932	putative substrate binding pocket [chemical binding]; other site
395961010933	dimer interface [polypeptide binding]; other site
395961010934	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
395961010935	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
395961010936	Walker A/P-loop; other site
395961010937	ATP binding site [chemical binding]; other site
395961010938	Q-loop/lid; other site
395961010939	ABC transporter signature motif; other site
395961010940	Walker B; other site
395961010941	D-loop; other site
395961010942	H-loop/switch region; other site
395961010943	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
395961010944	mce related protein; Region: MCE; pfam02470
395961010945	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
395961010946	MutS domain I; Region: MutS_I; pfam01624
395961010947	MutS domain II; Region: MutS_II; pfam05188
395961010948	MutS domain III; Region: MutS_III; pfam05192
395961010949	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
395961010950	Walker A/P-loop; other site
395961010951	ATP binding site [chemical binding]; other site
395961010952	Q-loop/lid; other site
395961010953	ABC transporter signature motif; other site
395961010954	Walker B; other site
395961010955	D-loop; other site
395961010956	H-loop/switch region; other site
395961010957	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
395961010958	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
395961010959	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395961010960	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395961010961	active site
395961010962	metal binding site [ion binding]; metal-binding site
395961010963	hypothetical protein; Provisional; Region: PRK13683
395961010964	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
395961010965	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
395961010966	Walker A/P-loop; other site
395961010967	ATP binding site [chemical binding]; other site
395961010968	Q-loop/lid; other site
395961010969	ABC transporter signature motif; other site
395961010970	Walker B; other site
395961010971	D-loop; other site
395961010972	H-loop/switch region; other site
395961010973	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
395961010974	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
395961010975	photosystem II protein K; Region: psbK; CHL00047
395961010976	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
395961010977	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395961010978	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
395961010979	Cupin domain; Region: Cupin_2; cl17218
395961010980	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
395961010981	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
395961010982	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
395961010983	Cupin domain; Region: Cupin_2; pfam07883
395961010984	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395961010985	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395961010986	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
395961010987	putative amphipathic alpha helix; other site
395961010988	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
395961010989	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
395961010990	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
395961010991	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
395961010992	Competence protein; Region: Competence; pfam03772
395961010993	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
395961010994	DNA adenine methylase (dam); Region: dam; TIGR00571
395961010995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961010996	S-adenosylmethionine binding site [chemical binding]; other site
395961010997	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395961010998	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395961010999	putative acyl-acceptor binding pocket; other site
395961011000	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
395961011001	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
395961011002	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
395961011003	Amidohydrolase; Region: Amidohydro_2; pfam04909
395961011004	active site
395961011005	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
395961011006	UbiA prenyltransferase family; Region: UbiA; pfam01040
395961011007	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961011008	active site
395961011009	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
395961011010	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
395961011011	nucleotide binding site [chemical binding]; other site
395961011012	putative NEF/HSP70 interaction site [polypeptide binding]; other site
395961011013	SBD interface [polypeptide binding]; other site
395961011014	PAS domain S-box; Region: sensory_box; TIGR00229
395961011015	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011016	putative active site [active]
395961011017	heme pocket [chemical binding]; other site
395961011018	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961011019	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961011020	metal binding site [ion binding]; metal-binding site
395961011021	active site
395961011022	I-site; other site
395961011023	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961011024	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
395961011025	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
395961011026	putative NAD(P) binding site [chemical binding]; other site
395961011027	putative substrate binding site [chemical binding]; other site
395961011028	catalytic Zn binding site [ion binding]; other site
395961011029	structural Zn binding site [ion binding]; other site
395961011030	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
395961011031	putative rRNA binding site [nucleotide binding]; other site
395961011032	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
395961011033	Amidinotransferase; Region: Amidinotransf; cl12043
395961011034	Uncharacterized conserved protein [Function unknown]; Region: COG1915
395961011035	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
395961011036	homodimer interface [polypeptide binding]; other site
395961011037	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395961011038	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
395961011039	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
395961011040	putative dimerization interface [polypeptide binding]; other site
395961011041	Transcriptional regulator [Transcription]; Region: LytR; COG1316
395961011042	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
395961011043	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
395961011044	Uncharacterized conserved protein [Function unknown]; Region: COG3937
395961011045	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
395961011046	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
395961011047	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
395961011048	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395961011049	active site
395961011050	metal binding site [ion binding]; metal-binding site
395961011051	hexamer interface [polypeptide binding]; other site
395961011052	cytochrome c553; Provisional; Region: petJ; CHL00183
395961011053	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395961011054	cytochrome c-550; Provisional; Region: psbV; PRK13621
395961011055	cytochrome c-550; Provisional; Region: psbV; cl17239
395961011056	cytochrome c-550; Provisional; Region: psbV; PRK13618
395961011057	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
395961011058	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
395961011059	ferredoxin-sulfite reductase; Region: sir; TIGR02042
395961011060	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395961011061	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395961011062	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
395961011063	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
395961011064	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
395961011065	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
395961011066	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
395961011067	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
395961011068	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
395961011069	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395961011070	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
395961011071	putative NAD(P) binding site [chemical binding]; other site
395961011072	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395961011073	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395961011074	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
395961011075	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
395961011076	active site
395961011077	dimer interface [polypeptide binding]; other site
395961011078	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
395961011079	Ligand Binding Site [chemical binding]; other site
395961011080	Molecular Tunnel; other site
395961011081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961011082	S-adenosylmethionine binding site [chemical binding]; other site
395961011083	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
395961011084	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
395961011085	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961011086	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
395961011087	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
395961011088	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961011089	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961011090	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961011091	active site
395961011092	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
395961011093	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
395961011094	ABC1 family; Region: ABC1; cl17513
395961011095	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961011096	putative active site [active]
395961011097	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
395961011098	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
395961011099	GTP binding site; other site
395961011100	acetyl-CoA synthetase; Provisional; Region: PRK00174
395961011101	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
395961011102	active site
395961011103	CoA binding site [chemical binding]; other site
395961011104	acyl-activating enzyme (AAE) consensus motif; other site
395961011105	AMP binding site [chemical binding]; other site
395961011106	acetate binding site [chemical binding]; other site
395961011107	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395961011108	Inward rectifier potassium channel; Region: IRK; pfam01007
395961011109	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
395961011110	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
395961011111	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
395961011112	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
395961011113	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
395961011114	Mg++ binding site [ion binding]; other site
395961011115	putative catalytic motif [active]
395961011116	putative substrate binding site [chemical binding]; other site
395961011117	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
395961011118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961011119	S-adenosylmethionine binding site [chemical binding]; other site
395961011120	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
395961011121	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961011122	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
395961011123	catalytic residues [active]
395961011124	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
395961011125	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395961011126	inhibitor-cofactor binding pocket; inhibition site
395961011127	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961011128	catalytic residue [active]
395961011129	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961011130	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011131	putative active site [active]
395961011132	heme pocket [chemical binding]; other site
395961011133	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011134	putative active site [active]
395961011135	heme pocket [chemical binding]; other site
395961011136	PAS domain S-box; Region: sensory_box; TIGR00229
395961011137	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011138	putative active site [active]
395961011139	heme pocket [chemical binding]; other site
395961011140	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961011141	Histidine kinase; Region: HisKA_2; pfam07568
395961011142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961011143	ATP binding site [chemical binding]; other site
395961011144	Mg2+ binding site [ion binding]; other site
395961011145	G-X-G motif; other site
395961011146	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
395961011147	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
395961011148	dimer interface [polypeptide binding]; other site
395961011149	motif 1; other site
395961011150	active site
395961011151	motif 2; other site
395961011152	motif 3; other site
395961011153	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395961011154	HSP70 interaction site [polypeptide binding]; other site
395961011155	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961011156	binding surface
395961011157	TPR repeat; Region: TPR_11; pfam13414
395961011158	TPR motif; other site
395961011159	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395961011160	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
395961011161	active site
395961011162	dimerization interface [polypeptide binding]; other site
395961011163	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395961011164	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395961011165	catalytic loop [active]
395961011166	iron binding site [ion binding]; other site
395961011167	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
395961011168	Probable transposase; Region: OrfB_IS605; pfam01385
395961011169	pyruvate kinase; Provisional; Region: PRK06354
395961011170	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
395961011171	domain interfaces; other site
395961011172	active site
395961011173	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
395961011174	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
395961011175	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
395961011176	Hexamer interface [polypeptide binding]; other site
395961011177	Hexagonal pore residue; other site
395961011178	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
395961011179	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
395961011180	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
395961011181	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
395961011182	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961011183	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961011184	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961011185	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
395961011186	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
395961011187	active site
395961011188	multimer interface [polypeptide binding]; other site
395961011189	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
395961011190	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961011191	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
395961011192	Transposase [DNA replication, recombination, and repair]; Region: COG5433
395961011193	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
395961011194	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395961011195	NAD binding site [chemical binding]; other site
395961011196	substrate binding site [chemical binding]; other site
395961011197	active site
395961011198	sucrose synthase; Region: sucr_synth; TIGR02470
395961011199	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
395961011200	putative ADP-binding pocket [chemical binding]; other site
395961011201	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
395961011202	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
395961011203	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
395961011204	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
395961011205	beta-phosphoglucomutase; Region: bPGM; TIGR01990
395961011206	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961011207	Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341
395961011208	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
395961011209	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
395961011210	putative dimer interface [polypeptide binding]; other site
395961011211	putative anticodon binding site; other site
395961011212	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
395961011213	homodimer interface [polypeptide binding]; other site
395961011214	motif 1; other site
395961011215	motif 2; other site
395961011216	active site
395961011217	motif 3; other site
395961011218	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395961011219	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395961011220	substrate binding pocket [chemical binding]; other site
395961011221	membrane-bound complex binding site; other site
395961011222	hinge residues; other site
395961011223	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961011224	non-specific DNA binding site [nucleotide binding]; other site
395961011225	sequence-specific DNA binding site [nucleotide binding]; other site
395961011226	salt bridge; other site
395961011227	Stage II sporulation protein; Region: SpoIID; pfam08486
395961011228	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
395961011229	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395961011230	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395961011231	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395961011232	active site
395961011233	catalytic tetrad [active]
395961011234	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
395961011235	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
395961011236	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395961011237	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395961011238	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
395961011239	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
395961011240	RNA binding site [nucleotide binding]; other site
395961011241	active site
395961011242	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
395961011243	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
395961011244	active site
395961011245	Substrate binding site; other site
395961011246	Mg++ binding site; other site
395961011247	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395961011248	putative trimer interface [polypeptide binding]; other site
395961011249	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395961011250	putative CoA binding site [chemical binding]; other site
395961011251	putative trimer interface [polypeptide binding]; other site
395961011252	putative CoA binding site [chemical binding]; other site
395961011253	arginine decarboxylase; Provisional; Region: PRK05354
395961011254	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
395961011255	dimer interface [polypeptide binding]; other site
395961011256	active site
395961011257	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395961011258	catalytic residues [active]
395961011259	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
395961011260	proline aminopeptidase P II; Provisional; Region: PRK10879
395961011261	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
395961011262	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
395961011263	active site
395961011264	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961011265	Ligand Binding Site [chemical binding]; other site
395961011266	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395961011267	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961011268	binding surface
395961011269	TPR motif; other site
395961011270	TPR repeat; Region: TPR_11; pfam13414
395961011271	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
395961011272	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
395961011273	P-loop; other site
395961011274	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
395961011275	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
395961011276	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395961011277	Cytochrome c; Region: Cytochrom_C; pfam00034
395961011278	cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665
395961011279	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
395961011280	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961011281	S-adenosylmethionine binding site [chemical binding]; other site
395961011282	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961011283	AAA domain; Region: AAA_21; pfam13304
395961011284	Walker A/P-loop; other site
395961011285	ATP binding site [chemical binding]; other site
395961011286	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
395961011287	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
395961011288	putative active site [active]
395961011289	oxyanion strand; other site
395961011290	catalytic triad [active]
395961011291	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
395961011292	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
395961011293	putative active site [active]
395961011294	substrate binding site [chemical binding]; other site
395961011295	putative cosubstrate binding site; other site
395961011296	catalytic site [active]
395961011297	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
395961011298	substrate binding site [chemical binding]; other site
395961011299	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
395961011300	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395961011301	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
395961011302	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395961011303	DNA binding residues [nucleotide binding]
395961011304	ChaB; Region: ChaB; cl01887
395961011305	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
395961011306	homodimer interface [polypeptide binding]; other site
395961011307	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
395961011308	active site pocket [active]
395961011309	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
395961011310	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
395961011311	Subunit I/III interface [polypeptide binding]; other site
395961011312	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
395961011313	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
395961011314	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
395961011315	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
395961011316	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
395961011317	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
395961011318	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395961011319	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
395961011320	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
395961011321	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395961011322	dimer interface [polypeptide binding]; other site
395961011323	putative metal binding site [ion binding]; other site
395961011324	Uncharacterized conserved protein [Function unknown]; Region: COG3349
395961011325	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961011326	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
395961011327	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
395961011328	substrate binding pocket [chemical binding]; other site
395961011329	chain length determination region; other site
395961011330	substrate-Mg2+ binding site; other site
395961011331	catalytic residues [active]
395961011332	aspartate-rich region 1; other site
395961011333	active site lid residues [active]
395961011334	aspartate-rich region 2; other site
395961011335	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
395961011336	Ca2+ binding site [ion binding]; other site
395961011337	EF-hand domain pair; Region: EF_hand_5; pfam13499
395961011338	EF-hand domain pair; Region: EF_hand_5; pfam13499
395961011339	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
395961011340	Ca2+ binding site [ion binding]; other site
395961011341	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
395961011342	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
395961011343	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395961011344	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
395961011345	phosphate binding site [ion binding]; other site
395961011346	AAA ATPase domain; Region: AAA_16; pfam13191
395961011347	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961011348	active site
395961011349	ATP binding site [chemical binding]; other site
395961011350	substrate binding site [chemical binding]; other site
395961011351	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
395961011352	activation loop (A-loop); other site
395961011353	AAA ATPase domain; Region: AAA_16; pfam13191
395961011354	Predicted ATPase [General function prediction only]; Region: COG3899
395961011355	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961011356	GAF domain; Region: GAF; pfam01590
395961011357	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395961011358	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
395961011359	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
395961011360	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395961011361	KWG Leptospira; Region: KWG; pfam07656
395961011362	KWG Leptospira; Region: KWG; pfam07656
395961011363	KWG Leptospira; Region: KWG; pfam07656
395961011364	KWG Leptospira; Region: KWG; pfam07656
395961011365	EVE domain; Region: EVE; cl00728
395961011366	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
395961011367	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
395961011368	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
395961011369	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
395961011370	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
395961011371	active site
395961011372	zinc binding site [ion binding]; other site
395961011373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961011374	dimer interface [polypeptide binding]; other site
395961011375	conserved gate region; other site
395961011376	putative PBP binding loops; other site
395961011377	ABC-ATPase subunit interface; other site
395961011378	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
395961011379	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
395961011380	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
395961011381	homotrimer interaction site [polypeptide binding]; other site
395961011382	zinc binding site [ion binding]; other site
395961011383	CDP-binding sites; other site
395961011384	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
395961011385	Domain of unknown function (DUF427); Region: DUF427; pfam04248
395961011386	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
395961011387	Glucose inhibited division protein A; Region: GIDA; pfam01134
395961011388	O-Antigen ligase; Region: Wzy_C; pfam04932
395961011389	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
395961011390	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
395961011391	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
395961011392	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395961011393	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
395961011394	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
395961011395	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961011396	motif II; other site
395961011397	Predicted flavoprotein [General function prediction only]; Region: COG0431
395961011398	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395961011399	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
395961011400	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
395961011401	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
395961011402	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
395961011403	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
395961011404	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
395961011405	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
395961011406	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
395961011407	photosystem I reaction center subunit IX; Provisional; Region: PRK02733
395961011408	Photosystem I reaction centre subunit III; Region: PSI_PsaF; pfam02507
395961011409	UGMP family protein; Validated; Region: PRK09604
395961011410	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
395961011411	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
395961011412	putative active site [active]
395961011413	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
395961011414	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
395961011415	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
395961011416	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
395961011417	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
395961011418	L11 interface [polypeptide binding]; other site
395961011419	putative EF-Tu interaction site [polypeptide binding]; other site
395961011420	putative EF-G interaction site [polypeptide binding]; other site
395961011421	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
395961011422	23S rRNA interface [nucleotide binding]; other site
395961011423	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
395961011424	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
395961011425	mRNA/rRNA interface [nucleotide binding]; other site
395961011426	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
395961011427	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
395961011428	23S rRNA interface [nucleotide binding]; other site
395961011429	L7/L12 interface [polypeptide binding]; other site
395961011430	putative thiostrepton binding site; other site
395961011431	L25 interface [polypeptide binding]; other site
395961011432	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
395961011433	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
395961011434	putative homodimer interface [polypeptide binding]; other site
395961011435	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
395961011436	heterodimer interface [polypeptide binding]; other site
395961011437	homodimer interface [polypeptide binding]; other site
395961011438	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
395961011439	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
395961011440	putative cation:proton antiport protein; Provisional; Region: PRK10669
395961011441	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
395961011442	TrkA-N domain; Region: TrkA_N; pfam02254
395961011443	TrkA-C domain; Region: TrkA_C; pfam02080
395961011444	TrkA-C domain; Region: TrkA_C; pfam02080
395961011445	tellurium resistance terB-like protein; Region: terB_like; cd07177
395961011446	metal binding site [ion binding]; metal-binding site
395961011447	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
395961011448	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
395961011449	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
395961011450	B12 binding site [chemical binding]; other site
395961011451	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961011452	FeS/SAM binding site; other site
395961011453	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
395961011454	signal recognition particle protein; Provisional; Region: PRK10867
395961011455	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
395961011456	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
395961011457	P loop; other site
395961011458	GTP binding site [chemical binding]; other site
395961011459	Signal peptide binding domain; Region: SRP_SPB; pfam02978
395961011460	pantothenate kinase; Reviewed; Region: PRK13331
395961011461	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
395961011462	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
395961011463	Walker A/P-loop; other site
395961011464	ATP binding site [chemical binding]; other site
395961011465	Q-loop/lid; other site
395961011466	ABC transporter signature motif; other site
395961011467	Walker B; other site
395961011468	D-loop; other site
395961011469	H-loop/switch region; other site
395961011470	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
395961011471	ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225
395961011472	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
395961011473	Cytochrome P450; Region: p450; cl12078
395961011474	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
395961011475	30S ribosomal protein S1; Reviewed; Region: PRK07400
395961011476	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
395961011477	RNA binding site [nucleotide binding]; other site
395961011478	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
395961011479	RNA binding site [nucleotide binding]; other site
395961011480	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
395961011481	RNA binding site [nucleotide binding]; other site
395961011482	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
395961011483	ATP cone domain; Region: ATP-cone; pfam03477
395961011484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961011485	dimer interface [polypeptide binding]; other site
395961011486	conserved gate region; other site
395961011487	ABC-ATPase subunit interface; other site
395961011488	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
395961011489	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
395961011490	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
395961011491	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
395961011492	putative active site [active]
395961011493	putative substrate binding site [chemical binding]; other site
395961011494	putative cosubstrate binding site; other site
395961011495	catalytic site [active]
395961011496	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
395961011497	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
395961011498	substrate binding site [chemical binding]; other site
395961011499	catalytic Zn binding site [ion binding]; other site
395961011500	NAD binding site [chemical binding]; other site
395961011501	structural Zn binding site [ion binding]; other site
395961011502	dimer interface [polypeptide binding]; other site
395961011503	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
395961011504	intersubunit interface [polypeptide binding]; other site
395961011505	active site
395961011506	zinc binding site [ion binding]; other site
395961011507	Na+ binding site [ion binding]; other site
395961011508	Protein of unknown function DUF104; Region: DUF104; cl11530
395961011509	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
395961011510	putative active site [active]
395961011511	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
395961011512	active site
395961011513	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
395961011514	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
395961011515	phosphoglyceromutase; Provisional; Region: PRK05434
395961011516	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
395961011517	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
395961011518	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395961011519	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
395961011520	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
395961011521	CP12 domain; Region: CP12; pfam02672
395961011522	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
395961011523	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
395961011524	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
395961011525	PAS domain S-box; Region: sensory_box; TIGR00229
395961011526	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011527	putative active site [active]
395961011528	heme pocket [chemical binding]; other site
395961011529	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
395961011530	dimer interface [polypeptide binding]; other site
395961011531	[2Fe-2S] cluster binding site [ion binding]; other site
395961011532	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
395961011533	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
395961011534	putative catalytic cysteine [active]
395961011535	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
395961011536	putative active site [active]
395961011537	metal binding site [ion binding]; metal-binding site
395961011538	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
395961011539	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395961011540	catalytic loop [active]
395961011541	iron binding site [ion binding]; other site
395961011542	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
395961011543	4Fe-4S binding domain; Region: Fer4; pfam00037
395961011544	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
395961011545	dimer interface [polypeptide binding]; other site
395961011546	[2Fe-2S] cluster binding site [ion binding]; other site
395961011547	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
395961011548	SLBB domain; Region: SLBB; pfam10531
395961011549	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
395961011550	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
395961011551	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
395961011552	putative dimer interface [polypeptide binding]; other site
395961011553	[2Fe-2S] cluster binding site [ion binding]; other site
395961011554	putative acyltransferase; Provisional; Region: PRK05790
395961011555	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
395961011556	dimer interface [polypeptide binding]; other site
395961011557	active site
395961011558	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395961011559	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961011560	NAD(P) binding site [chemical binding]; other site
395961011561	active site
395961011562	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914
395961011563	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
395961011564	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
395961011565	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
395961011566	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
395961011567	Moco binding site; other site
395961011568	metal coordination site [ion binding]; other site
395961011569	ribosomal protein L32; Validated; Region: rpl32; CHL00152
395961011570	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961011571	phosphopeptide binding site; other site
395961011572	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961011573	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961011574	phosphopeptide binding site; other site
395961011575	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
395961011576	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
395961011577	Walker A/P-loop; other site
395961011578	ATP binding site [chemical binding]; other site
395961011579	Q-loop/lid; other site
395961011580	ABC transporter signature motif; other site
395961011581	Walker B; other site
395961011582	D-loop; other site
395961011583	H-loop/switch region; other site
395961011584	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395961011585	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
395961011586	aspartate aminotransferase; Provisional; Region: PRK05764
395961011587	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395961011588	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961011589	homodimer interface [polypeptide binding]; other site
395961011590	catalytic residue [active]
395961011591	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
395961011592	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961011593	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395961011594	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395961011595	active site
395961011596	metal binding site [ion binding]; metal-binding site
395961011597	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
395961011598	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
395961011599	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
395961011600	Walker A/P-loop; other site
395961011601	ATP binding site [chemical binding]; other site
395961011602	Q-loop/lid; other site
395961011603	ABC transporter signature motif; other site
395961011604	Walker B; other site
395961011605	D-loop; other site
395961011606	H-loop/switch region; other site
395961011607	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395961011608	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961011609	Coenzyme A binding pocket [chemical binding]; other site
395961011610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961011611	TPR motif; other site
395961011612	binding surface
395961011613	TPR repeat; Region: TPR_11; pfam13414
395961011614	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961011615	binding surface
395961011616	TPR motif; other site
395961011617	TPR repeat; Region: TPR_11; pfam13414
395961011618	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961011619	binding surface
395961011620	TPR motif; other site
395961011621	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
395961011622	hypothetical protein; Provisional; Region: PRK02237
395961011623	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
395961011624	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
395961011625	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
395961011626	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961011627	Ligand Binding Site [chemical binding]; other site
395961011628	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961011629	Ligand Binding Site [chemical binding]; other site
395961011630	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
395961011631	active site
395961011632	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
395961011633	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
395961011634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395961011635	active site
395961011636	phosphorylation site [posttranslational modification]
395961011637	intermolecular recognition site; other site
395961011638	dimerization interface [polypeptide binding]; other site
395961011639	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395961011640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961011641	dimer interface [polypeptide binding]; other site
395961011642	conserved gate region; other site
395961011643	putative PBP binding loops; other site
395961011644	ABC-ATPase subunit interface; other site
395961011645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961011646	dimer interface [polypeptide binding]; other site
395961011647	conserved gate region; other site
395961011648	putative PBP binding loops; other site
395961011649	ABC-ATPase subunit interface; other site
395961011650	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395961011651	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395961011652	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
395961011653	active site
395961011654	catalytic residues [active]
395961011655	DNA binding site [nucleotide binding]
395961011656	Int/Topo IB signature motif; other site
395961011657	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755
395961011658	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
395961011659	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
395961011660	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
395961011661	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
395961011662	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
395961011663	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
395961011664	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670
395961011665	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
395961011666	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
395961011667	helicase Cas3; Provisional; Region: PRK09694
395961011668	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
395961011669	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
395961011670	Predicted transcriptional regulator [Transcription]; Region: COG2378
395961011671	HTH domain; Region: HTH_11; pfam08279
395961011672	WYL domain; Region: WYL; pfam13280
395961011673	Ycf46; Provisional; Region: ycf46; CHL00195
395961011674	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961011675	Walker A motif; other site
395961011676	ATP binding site [chemical binding]; other site
395961011677	Walker B motif; other site
395961011678	arginine finger; other site
395961011679	Protein of unknown function (DUF1257); Region: DUF1257; cl06088
395961011680	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961011681	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961011682	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961011683	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395961011684	Uncharacterized conserved protein [Function unknown]; Region: COG1262
395961011685	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
395961011686	nucleotide binding site [chemical binding]; other site
395961011687	putative NEF/HSP70 interaction site [polypeptide binding]; other site
395961011688	SBD interface [polypeptide binding]; other site
395961011689	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
395961011690	dimer interface [polypeptide binding]; other site
395961011691	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
395961011692	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
395961011693	Leucine rich repeat variant; Region: LRV; pfam01816
395961011694	HEAT repeats; Region: HEAT_2; pfam13646
395961011695	Leucine rich repeat variant; Region: LRV; pfam01816
395961011696	HEAT repeats; Region: HEAT_2; pfam13646
395961011697	HEAT repeats; Region: HEAT_2; pfam13646
395961011698	GUN4-like; Region: GUN4; pfam05419
395961011699	MobA/MobL family; Region: MobA_MobL; pfam03389
395961011700	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
395961011701	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
395961011702	GIY-YIG motif/motif A; other site
395961011703	active site
395961011704	catalytic site [active]
395961011705	metal binding site [ion binding]; metal-binding site
395961011706	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
395961011707	Part of AAA domain; Region: AAA_19; pfam13245
395961011708	Family description; Region: UvrD_C_2; pfam13538
395961011709	HNH endonuclease; Region: HNH_3; pfam13392
395961011710	PGAP1-like protein; Region: PGAP1; pfam07819
395961011711	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395961011712	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
395961011713	Response regulator receiver domain; Region: Response_reg; pfam00072
395961011714	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961011715	active site
395961011716	phosphorylation site [posttranslational modification]
395961011717	intermolecular recognition site; other site
395961011718	dimerization interface [polypeptide binding]; other site
395961011719	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961011720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961011721	phosphorylation site [posttranslational modification]
395961011722	intermolecular recognition site; other site
395961011723	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011724	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961011725	putative active site [active]
395961011726	heme pocket [chemical binding]; other site
395961011727	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011728	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961011729	putative active site [active]
395961011730	heme pocket [chemical binding]; other site
395961011731	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011732	putative active site [active]
395961011733	heme pocket [chemical binding]; other site
395961011734	PAS domain S-box; Region: sensory_box; TIGR00229
395961011735	PAS domain; Region: PAS_9; pfam13426
395961011736	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011737	putative active site [active]
395961011738	heme pocket [chemical binding]; other site
395961011739	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961011740	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961011741	dimer interface [polypeptide binding]; other site
395961011742	phosphorylation site [posttranslational modification]
395961011743	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961011744	ATP binding site [chemical binding]; other site
395961011745	Mg2+ binding site [ion binding]; other site
395961011746	G-X-G motif; other site
395961011747	Response regulator receiver domain; Region: Response_reg; pfam00072
395961011748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961011749	active site
395961011750	phosphorylation site [posttranslational modification]
395961011751	intermolecular recognition site; other site
395961011752	dimerization interface [polypeptide binding]; other site
395961011753	glycogen branching enzyme; Provisional; Region: PRK05402
395961011754	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
395961011755	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
395961011756	active site
395961011757	catalytic site [active]
395961011758	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
395961011759	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
395961011760	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395961011761	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961011762	Coenzyme A binding pocket [chemical binding]; other site
395961011763	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395961011764	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
395961011765	nucleophilic elbow; other site
395961011766	catalytic triad; other site
395961011767	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
395961011768	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
395961011769	dimer interface [polypeptide binding]; other site
395961011770	tetramer interface [polypeptide binding]; other site
395961011771	PYR/PP interface [polypeptide binding]; other site
395961011772	TPP binding site [chemical binding]; other site
395961011773	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
395961011774	TPP-binding site; other site
395961011775	Guanylate kinase; Region: Guanylate_kin; pfam00625
395961011776	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
395961011777	catalytic site [active]
395961011778	G-X2-G-X-G-K; other site
395961011779	hypothetical protein; Provisional; Region: PRK04323
395961011780	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
395961011781	Domain of unknown function (DUF814); Region: DUF814; pfam05670
395961011782	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
395961011783	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
395961011784	nucleotide binding site [chemical binding]; other site
395961011785	NEF interaction site [polypeptide binding]; other site
395961011786	SBD interface [polypeptide binding]; other site
395961011787	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395961011788	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
395961011789	putative dimer interface [polypeptide binding]; other site
395961011790	PRC-barrel domain; Region: PRC; pfam05239
395961011791	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
395961011792	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
395961011793	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
395961011794	TPP-binding site; other site
395961011795	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
395961011796	PYR/PP interface [polypeptide binding]; other site
395961011797	dimer interface [polypeptide binding]; other site
395961011798	TPP binding site [chemical binding]; other site
395961011799	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395961011800	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
395961011801	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961011802	motif II; other site
395961011803	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
395961011804	S-adenosylmethionine synthetase; Validated; Region: PRK05250
395961011805	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
395961011806	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
395961011807	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
395961011808	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
395961011809	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395961011810	Soluble P-type ATPase [General function prediction only]; Region: COG4087
395961011811	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961011812	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961011813	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961011814	Rrf2 family protein; Region: rrf2_super; TIGR00738
395961011815	Transcriptional regulator; Region: Rrf2; cl17282
395961011816	Cache domain; Region: Cache_1; pfam02743
395961011817	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
395961011818	PAS domain S-box; Region: sensory_box; TIGR00229
395961011819	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011820	putative active site [active]
395961011821	heme pocket [chemical binding]; other site
395961011822	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961011823	Histidine kinase; Region: HisKA_2; pfam07568
395961011824	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961011825	ATP binding site [chemical binding]; other site
395961011826	Mg2+ binding site [ion binding]; other site
395961011827	G-X-G motif; other site
395961011828	Cache domain; Region: Cache_1; pfam02743
395961011829	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
395961011830	PAS domain S-box; Region: sensory_box; TIGR00229
395961011831	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011832	putative active site [active]
395961011833	heme pocket [chemical binding]; other site
395961011834	PAS domain S-box; Region: sensory_box; TIGR00229
395961011835	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011836	putative active site [active]
395961011837	heme pocket [chemical binding]; other site
395961011838	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961011839	Histidine kinase; Region: HisKA_2; pfam07568
395961011840	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
395961011841	ATP binding site [chemical binding]; other site
395961011842	Mg2+ binding site [ion binding]; other site
395961011843	G-X-G motif; other site
395961011844	Cache domain; Region: Cache_1; pfam02743
395961011845	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961011846	dimerization interface [polypeptide binding]; other site
395961011847	PAS domain S-box; Region: sensory_box; TIGR00229
395961011848	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011849	putative active site [active]
395961011850	heme pocket [chemical binding]; other site
395961011851	PAS domain S-box; Region: sensory_box; TIGR00229
395961011852	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011853	putative active site [active]
395961011854	heme pocket [chemical binding]; other site
395961011855	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011856	PAS fold; Region: PAS_3; pfam08447
395961011857	putative active site [active]
395961011858	heme pocket [chemical binding]; other site
395961011859	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961011860	Histidine kinase; Region: HisKA_2; pfam07568
395961011861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961011862	ATP binding site [chemical binding]; other site
395961011863	Mg2+ binding site [ion binding]; other site
395961011864	G-X-G motif; other site
395961011865	PAS domain S-box; Region: sensory_box; TIGR00229
395961011866	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011867	putative active site [active]
395961011868	heme pocket [chemical binding]; other site
395961011869	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961011870	PAS fold; Region: PAS_3; pfam08447
395961011871	putative active site [active]
395961011872	heme pocket [chemical binding]; other site
395961011873	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961011874	Histidine kinase; Region: HisKA_2; pfam07568
395961011875	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961011876	ATP binding site [chemical binding]; other site
395961011877	Mg2+ binding site [ion binding]; other site
395961011878	G-X-G motif; other site
395961011879	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
395961011880	Double zinc ribbon; Region: DZR; pfam12773
395961011881	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
395961011882	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
395961011883	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961011884	putative Mg++ binding site [ion binding]; other site
395961011885	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961011886	nucleotide binding region [chemical binding]; other site
395961011887	ATP-binding site [chemical binding]; other site
395961011888	Putative serine esterase (DUF676); Region: DUF676; pfam05057
395961011889	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
395961011890	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961011891	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961011892	Homeodomain-like domain; Region: HTH_23; pfam13384
395961011893	Winged helix-turn helix; Region: HTH_29; pfam13551
395961011894	Homeodomain-like domain; Region: HTH_32; pfam13565
395961011895	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
395961011896	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
395961011897	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395961011898	active site
395961011899	DNA binding site [nucleotide binding]
395961011900	Int/Topo IB signature motif; other site
395961011901	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
395961011902	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
395961011903	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395961011904	active site
395961011905	DNA binding site [nucleotide binding]
395961011906	Int/Topo IB signature motif; other site
395961011907	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
395961011908	Sensors of blue-light using FAD; Region: BLUF; smart01034
395961011909	Uncharacterized conserved protein [Function unknown]; Region: COG4278
395961011910	TIGR04222 domain; Region: near_uncomplex
395961011911	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
395961011912	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
395961011913	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395961011914	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
395961011915	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961011916	motif II; other site
395961011917	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
395961011918	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
395961011919	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
395961011920	hypothetical protein; Provisional; Region: PRK02509
395961011921	PemK-like protein; Region: PemK; cl00995
395961011922	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
395961011923	Protein of unknown function DUF262; Region: DUF262; pfam03235
395961011924	Uncharacterized conserved protein [Function unknown]; Region: COG1479
395961011925	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
395961011926	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
395961011927	oligomerization interface [polypeptide binding]; other site
395961011928	active site
395961011929	metal binding site [ion binding]; metal-binding site
395961011930	Ferredoxin [Energy production and conversion]; Region: COG1146
395961011931	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
395961011932	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
395961011933	Moco binding site; other site
395961011934	metal coordination site [ion binding]; other site
395961011935	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
395961011936	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
395961011937	methionine sulfoxide reductase A; Provisional; Region: PRK13014
395961011938	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
395961011939	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
395961011940	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
395961011941	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395961011942	catalytic residues [active]
395961011943	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
395961011944	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395961011945	Walker A/P-loop; other site
395961011946	ATP binding site [chemical binding]; other site
395961011947	Q-loop/lid; other site
395961011948	ABC transporter signature motif; other site
395961011949	Walker B; other site
395961011950	D-loop; other site
395961011951	H-loop/switch region; other site
395961011952	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
395961011953	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
395961011954	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
395961011955	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
395961011956	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
395961011957	RNA methyltransferase, RsmE family; Region: TIGR00046
395961011958	Predicted membrane protein [Function unknown]; Region: COG2246
395961011959	GtrA-like protein; Region: GtrA; pfam04138
395961011960	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
395961011961	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
395961011962	Ligand binding site; other site
395961011963	Putative Catalytic site; other site
395961011964	DXD motif; other site
395961011965	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
395961011966	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
395961011967	DNA binding site [nucleotide binding]
395961011968	catalytic residue [active]
395961011969	H2TH interface [polypeptide binding]; other site
395961011970	putative catalytic residues [active]
395961011971	turnover-facilitating residue; other site
395961011972	intercalation triad [nucleotide binding]; other site
395961011973	8OG recognition residue [nucleotide binding]; other site
395961011974	putative reading head residues; other site
395961011975	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
395961011976	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
395961011977	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
395961011978	Protein of unknown function (DUF760); Region: DUF760; pfam05542
395961011979	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
395961011980	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
395961011981	minor groove reading motif; other site
395961011982	helix-hairpin-helix signature motif; other site
395961011983	substrate binding pocket [chemical binding]; other site
395961011984	active site
395961011985	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
395961011986	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
395961011987	active site
395961011988	8-oxo-dGMP binding site [chemical binding]; other site
395961011989	nudix motif; other site
395961011990	metal binding site [ion binding]; metal-binding site
395961011991	recombination protein RecR; Reviewed; Region: recR; PRK00076
395961011992	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
395961011993	RecR protein; Region: RecR; pfam02132
395961011994	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
395961011995	putative active site [active]
395961011996	putative metal-binding site [ion binding]; other site
395961011997	tetramer interface [polypeptide binding]; other site
395961011998	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
395961011999	DNA primase; Validated; Region: dnaG; PRK05667
395961012000	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
395961012001	Predicted membrane protein [Function unknown]; Region: COG3431
395961012002	chaperone protein DnaJ; Provisional; Region: PRK14299
395961012003	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395961012004	HSP70 interaction site [polypeptide binding]; other site
395961012005	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
395961012006	dimer interface [polypeptide binding]; other site
395961012007	molecular chaperone DnaK; Provisional; Region: PRK13410
395961012008	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
395961012009	nucleotide binding site [chemical binding]; other site
395961012010	NEF interaction site [polypeptide binding]; other site
395961012011	SBD interface [polypeptide binding]; other site
395961012012	phytoene desaturase; Region: phytoene_desat; TIGR02731
395961012013	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961012014	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
395961012015	active site lid residues [active]
395961012016	substrate binding pocket [chemical binding]; other site
395961012017	catalytic residues [active]
395961012018	substrate-Mg2+ binding site; other site
395961012019	aspartate-rich region 1; other site
395961012020	aspartate-rich region 2; other site
395961012021	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961012022	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961012023	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961012024	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395961012025	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395961012026	Walker A/P-loop; other site
395961012027	ATP binding site [chemical binding]; other site
395961012028	Q-loop/lid; other site
395961012029	ABC transporter signature motif; other site
395961012030	Walker B; other site
395961012031	D-loop; other site
395961012032	H-loop/switch region; other site
395961012033	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
395961012034	putative amphipathic alpha helix; other site
395961012035	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
395961012036	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961012037	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961012038	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961012039	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961012040	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961012041	hydrolase, alpha/beta fold family protein; Region: PLN02824
395961012042	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395961012043	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
395961012044	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
395961012045	inhibitor-cofactor binding pocket; inhibition site
395961012046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961012047	catalytic residue [active]
395961012048	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
395961012049	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961012050	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
395961012051	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
395961012052	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
395961012053	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
395961012054	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
395961012055	Ligand binding site; other site
395961012056	oligomer interface; other site
395961012057	KpsF/GutQ family protein; Region: kpsF; TIGR00393
395961012058	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
395961012059	putative active site [active]
395961012060	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
395961012061	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395961012062	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
395961012063	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
395961012064	Walker A/P-loop; other site
395961012065	ATP binding site [chemical binding]; other site
395961012066	Q-loop/lid; other site
395961012067	ABC transporter signature motif; other site
395961012068	Walker B; other site
395961012069	D-loop; other site
395961012070	H-loop/switch region; other site
395961012071	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
395961012072	putative carbohydrate binding site [chemical binding]; other site
395961012073	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
395961012074	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395961012075	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961012076	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
395961012077	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
395961012078	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961012079	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
395961012080	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
395961012081	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961012082	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
395961012083	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
395961012084	Probable Catalytic site; other site
395961012085	metal-binding site
395961012086	O-Antigen ligase; Region: Wzy_C; pfam04932
395961012087	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
395961012088	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
395961012089	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395961012090	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961012091	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
395961012092	putative ADP-binding pocket [chemical binding]; other site
395961012093	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
395961012094	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395961012095	Cl- selectivity filter; other site
395961012096	Cl- binding residues [ion binding]; other site
395961012097	pore gating glutamate residue; other site
395961012098	dimer interface [polypeptide binding]; other site
395961012099	H+/Cl- coupling transport residue; other site
395961012100	FOG: CBS domain [General function prediction only]; Region: COG0517
395961012101	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
395961012102	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
395961012103	Ligand Binding Site [chemical binding]; other site
395961012104	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961012105	Ligand Binding Site [chemical binding]; other site
395961012106	methionine sulfoxide reductase B; Provisional; Region: PRK00222
395961012107	SelR domain; Region: SelR; pfam01641
395961012108	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961012109	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961012110	phosphopeptide binding site; other site
395961012111	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
395961012112	ATP adenylyltransferase; Region: ATP_transf; pfam09830
395961012113	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395961012114	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395961012115	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395961012116	catalytic residue [active]
395961012117	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
395961012118	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
395961012119	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395961012120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961012121	putative substrate translocation pore; other site
395961012122	Uncharacterized conserved protein [Function unknown]; Region: COG0432
395961012123	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
395961012124	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395961012125	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961012126	homodimer interface [polypeptide binding]; other site
395961012127	catalytic residue [active]
395961012128	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
395961012129	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
395961012130	active site
395961012131	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395961012132	catalytic residues [active]
395961012133	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
395961012134	adenylosuccinate lyase; Provisional; Region: PRK07380
395961012135	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
395961012136	tetramer interface [polypeptide binding]; other site
395961012137	active site
395961012138	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
395961012139	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961012140	elongation factor Ts; Reviewed; Region: tsf; PRK12332
395961012141	UBA/TS-N domain; Region: UBA; pfam00627
395961012142	Elongation factor TS; Region: EF_TS; pfam00889
395961012143	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
395961012144	rRNA interaction site [nucleotide binding]; other site
395961012145	S8 interaction site; other site
395961012146	putative laminin-1 binding site; other site
395961012147	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
395961012148	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
395961012149	Ligand binding site; other site
395961012150	Putative Catalytic site; other site
395961012151	DXD motif; other site
395961012152	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
395961012153	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
395961012154	active site
395961012155	HIGH motif; other site
395961012156	dimer interface [polypeptide binding]; other site
395961012157	KMSKS motif; other site
395961012158	phosphoribulokinase; Provisional; Region: PRK07429
395961012159	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
395961012160	active site
395961012161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
395961012162	FIST N domain; Region: FIST; pfam08495
395961012163	FIST C domain; Region: FIST_C; pfam10442
395961012164	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
395961012165	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
395961012166	PsaD; Region: PsaD; pfam02531
395961012167	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
395961012168	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
395961012169	dimer interface [polypeptide binding]; other site
395961012170	ssDNA binding site [nucleotide binding]; other site
395961012171	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395961012172	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395961012173	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
395961012174	dimer interface [polypeptide binding]; other site
395961012175	active site
395961012176	metal binding site [ion binding]; metal-binding site
395961012177	glutathione binding site [chemical binding]; other site
395961012178	S-layer homology domain; Region: SLH; pfam00395
395961012179	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
395961012180	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
395961012181	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
395961012182	ABC1 family; Region: ABC1; cl17513
395961012183	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395961012184	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395961012185	TM-ABC transporter signature motif; other site
395961012186	YHYH protein; Region: YHYH; pfam14240
395961012187	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961012188	structural tetrad; other site
395961012189	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395961012190	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961012191	structural tetrad; other site
395961012192	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961012193	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961012194	active site
395961012195	ATP binding site [chemical binding]; other site
395961012196	substrate binding site [chemical binding]; other site
395961012197	activation loop (A-loop); other site
395961012198	cell division protein; Validated; Region: ftsH; CHL00176
395961012199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961012200	Walker A motif; other site
395961012201	ATP binding site [chemical binding]; other site
395961012202	Walker B motif; other site
395961012203	arginine finger; other site
395961012204	Peptidase family M41; Region: Peptidase_M41; pfam01434
395961012205	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961012206	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961012207	Homeodomain-like domain; Region: HTH_23; pfam13384
395961012208	Winged helix-turn helix; Region: HTH_29; pfam13551
395961012209	Homeodomain-like domain; Region: HTH_32; pfam13565
395961012210	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
395961012211	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
395961012212	putative di-iron ligands [ion binding]; other site
395961012213	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
395961012214	active site
395961012215	dinuclear metal binding site [ion binding]; other site
395961012216	dimerization interface [polypeptide binding]; other site
395961012217	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
395961012218	homoserine dehydrogenase; Provisional; Region: PRK06349
395961012219	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
395961012220	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
395961012221	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
395961012222	GTP-binding protein YchF; Reviewed; Region: PRK09601
395961012223	YchF GTPase; Region: YchF; cd01900
395961012224	G1 box; other site
395961012225	GTP/Mg2+ binding site [chemical binding]; other site
395961012226	Switch I region; other site
395961012227	G2 box; other site
395961012228	Switch II region; other site
395961012229	G3 box; other site
395961012230	G4 box; other site
395961012231	G5 box; other site
395961012232	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
395961012233	Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931
395961012234	Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932
395961012235	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
395961012236	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
395961012237	RNase E interface [polypeptide binding]; other site
395961012238	trimer interface [polypeptide binding]; other site
395961012239	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
395961012240	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
395961012241	RNase E interface [polypeptide binding]; other site
395961012242	trimer interface [polypeptide binding]; other site
395961012243	active site
395961012244	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
395961012245	putative nucleic acid binding region [nucleotide binding]; other site
395961012246	G-X-X-G motif; other site
395961012247	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
395961012248	RNA binding site [nucleotide binding]; other site
395961012249	domain interface; other site
395961012250	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
395961012251	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
395961012252	cofactor binding site; other site
395961012253	DNA binding site [nucleotide binding]
395961012254	substrate interaction site [chemical binding]; other site
395961012255	flavoprotein, HI0933 family; Region: TIGR00275
395961012256	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
395961012257	putative active site [active]
395961012258	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
395961012259	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961012260	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
395961012261	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
395961012262	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
395961012263	dimer interface [polypeptide binding]; other site
395961012264	substrate binding site [chemical binding]; other site
395961012265	ATP binding site [chemical binding]; other site
395961012266	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
395961012267	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
395961012268	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
395961012269	active site
395961012270	intersubunit interface [polypeptide binding]; other site
395961012271	catalytic residue [active]
395961012272	PRC-barrel domain; Region: PRC; pfam05239
395961012273	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
395961012274	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
395961012275	NAD binding site [chemical binding]; other site
395961012276	homotetramer interface [polypeptide binding]; other site
395961012277	homodimer interface [polypeptide binding]; other site
395961012278	substrate binding site [chemical binding]; other site
395961012279	active site
395961012280	Penicillinase repressor; Region: Pencillinase_R; cl17580
395961012281	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
395961012282	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961012283	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961012284	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
395961012285	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961012286	dimerization interface [polypeptide binding]; other site
395961012287	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
395961012288	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
395961012289	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395961012290	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
395961012291	active site
395961012292	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
395961012293	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961012294	non-specific DNA binding site [nucleotide binding]; other site
395961012295	salt bridge; other site
395961012296	sequence-specific DNA binding site [nucleotide binding]; other site
395961012297	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961012298	salt bridge; other site
395961012299	non-specific DNA binding site [nucleotide binding]; other site
395961012300	sequence-specific DNA binding site [nucleotide binding]; other site
395961012301	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395961012302	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395961012303	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
395961012304	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
395961012305	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
395961012306	NADP binding site [chemical binding]; other site
395961012307	active site
395961012308	putative substrate binding site [chemical binding]; other site
395961012309	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
395961012310	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
395961012311	substrate binding site; other site
395961012312	metal-binding site
395961012313	Oligomer interface; other site
395961012314	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395961012315	putative trimer interface [polypeptide binding]; other site
395961012316	putative CoA binding site [chemical binding]; other site
395961012317	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
395961012318	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
395961012319	NAD binding site [chemical binding]; other site
395961012320	substrate binding site [chemical binding]; other site
395961012321	homodimer interface [polypeptide binding]; other site
395961012322	active site
395961012323	ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020
395961012324	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
395961012325	putative multimerization interface [polypeptide binding]; other site
395961012326	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
395961012327	putative catalytic residues [active]
395961012328	Response regulator receiver domain; Region: Response_reg; pfam00072
395961012329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961012330	active site
395961012331	phosphorylation site [posttranslational modification]
395961012332	intermolecular recognition site; other site
395961012333	dimerization interface [polypeptide binding]; other site
395961012334	PAS domain S-box; Region: sensory_box; TIGR00229
395961012335	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012336	putative active site [active]
395961012337	heme pocket [chemical binding]; other site
395961012338	PAS fold; Region: PAS_3; pfam08447
395961012339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012340	PAS fold; Region: PAS_3; pfam08447
395961012341	putative active site [active]
395961012342	heme pocket [chemical binding]; other site
395961012343	PAS fold; Region: PAS_3; pfam08447
395961012344	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012345	putative active site [active]
395961012346	heme pocket [chemical binding]; other site
395961012347	PAS fold; Region: PAS_4; pfam08448
395961012348	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012349	PAS fold; Region: PAS_3; pfam08447
395961012350	putative active site [active]
395961012351	heme pocket [chemical binding]; other site
395961012352	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961012353	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012354	putative active site [active]
395961012355	heme pocket [chemical binding]; other site
395961012356	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012357	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961012358	putative active site [active]
395961012359	heme pocket [chemical binding]; other site
395961012360	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012361	putative active site [active]
395961012362	heme pocket [chemical binding]; other site
395961012363	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012364	PAS fold; Region: PAS_3; pfam08447
395961012365	putative active site [active]
395961012366	heme pocket [chemical binding]; other site
395961012367	PAS fold; Region: PAS_3; pfam08447
395961012368	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012369	putative active site [active]
395961012370	heme pocket [chemical binding]; other site
395961012371	PAS fold; Region: PAS_4; pfam08448
395961012372	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012373	putative active site [active]
395961012374	heme pocket [chemical binding]; other site
395961012375	PAS domain S-box; Region: sensory_box; TIGR00229
395961012376	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012377	putative active site [active]
395961012378	heme pocket [chemical binding]; other site
395961012379	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961012380	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961012381	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012382	PAS fold; Region: PAS_3; pfam08447
395961012383	putative active site [active]
395961012384	heme pocket [chemical binding]; other site
395961012385	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012386	PAS fold; Region: PAS_3; pfam08447
395961012387	putative active site [active]
395961012388	heme pocket [chemical binding]; other site
395961012389	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961012390	GAF domain; Region: GAF; pfam01590
395961012391	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961012392	Histidine kinase; Region: HisKA_2; pfam07568
395961012393	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961012394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961012395	active site
395961012396	phosphorylation site [posttranslational modification]
395961012397	intermolecular recognition site; other site
395961012398	dimerization interface [polypeptide binding]; other site
395961012399	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961012400	Histidine kinase; Region: HisKA_2; pfam07568
395961012401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961012402	ATP binding site [chemical binding]; other site
395961012403	Mg2+ binding site [ion binding]; other site
395961012404	G-X-G motif; other site
395961012405	PRC-barrel domain; Region: PRC; pfam05239
395961012406	PRC-barrel domain; Region: PRC; pfam05239
395961012407	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
395961012408	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
395961012409	putative catalytic cysteine [active]
395961012410	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
395961012411	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
395961012412	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
395961012413	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961012414	Ligand Binding Site [chemical binding]; other site
395961012415	DnaJ domain; Region: DnaJ; pfam00226
395961012416	HSP70 interaction site [polypeptide binding]; other site
395961012417	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
395961012418	GTP/Mg2+ binding site [chemical binding]; other site
395961012419	G4 box; other site
395961012420	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
395961012421	Dynamin family; Region: Dynamin_N; pfam00350
395961012422	G1 box; other site
395961012423	G1 box; other site
395961012424	GTP/Mg2+ binding site [chemical binding]; other site
395961012425	G2 box; other site
395961012426	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
395961012427	G3 box; other site
395961012428	Switch II region; other site
395961012429	G4 box; other site
395961012430	transposase; Validated; Region: PRK08181
395961012431	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961012432	Walker A motif; other site
395961012433	ATP binding site [chemical binding]; other site
395961012434	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
395961012435	nucleotide binding site [chemical binding]; other site
395961012436	CHC2 zinc finger; Region: zf-CHC2; cl17510
395961012437	AAA domain; Region: AAA_25; pfam13481
395961012438	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395961012439	Walker A motif; other site
395961012440	ATP binding site [chemical binding]; other site
395961012441	Walker B motif; other site
395961012442	Predicted transcriptional regulators [Transcription]; Region: COG1695
395961012443	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
395961012444	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
395961012445	active site
395961012446	catalytic residues [active]
395961012447	DNA binding site [nucleotide binding]
395961012448	Int/Topo IB signature motif; other site
395961012449	Protein of unknown function (DUF565); Region: DUF565; pfam04483
395961012450	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
395961012451	Peptidase family M48; Region: Peptidase_M48; pfam01435
395961012452	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
395961012453	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
395961012454	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395961012455	acylphosphatase; Provisional; Region: PRK14423
395961012456	ParB-like nuclease domain; Region: ParBc; cl02129
395961012457	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
395961012458	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
395961012459	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395961012460	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961012461	Walker A/P-loop; other site
395961012462	ATP binding site [chemical binding]; other site
395961012463	Q-loop/lid; other site
395961012464	ABC transporter signature motif; other site
395961012465	Walker B; other site
395961012466	D-loop; other site
395961012467	H-loop/switch region; other site
395961012468	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374
395961012469	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
395961012470	active site
395961012471	PHP Thumb interface [polypeptide binding]; other site
395961012472	metal binding site [ion binding]; metal-binding site
395961012473	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
395961012474	generic binding surface I; other site
395961012475	generic binding surface II; other site
395961012476	YGGT family; Region: YGGT; pfam02325
395961012477	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395961012478	active site
395961012479	threonine synthase; Reviewed; Region: PRK06721
395961012480	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
395961012481	homodimer interface [polypeptide binding]; other site
395961012482	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961012483	catalytic residue [active]
395961012484	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
395961012485	diiron binding motif [ion binding]; other site
395961012486	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
395961012487	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
395961012488	putative RNA binding site [nucleotide binding]; other site
395961012489	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395961012490	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395961012491	protein binding site [polypeptide binding]; other site
395961012492	glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482
395961012493	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395961012494	inhibitor-cofactor binding pocket; inhibition site
395961012495	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961012496	catalytic residue [active]
395961012497	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
395961012498	hypothetical protein; Validated; Region: PRK00110
395961012499	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395961012500	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961012501	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961012502	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961012503	Tat binding protein 1(TBP-1)-interacting protein (TBPIP); Region: TBPIP; pfam07106
395961012504	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
395961012505	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
395961012506	catalytic motif [active]
395961012507	Zn binding site [ion binding]; other site
395961012508	RibD C-terminal domain; Region: RibD_C; cl17279
395961012509	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961012510	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961012511	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961012512	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
395961012513	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395961012514	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
395961012515	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
395961012516	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
395961012517	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
395961012518	dihydrodipicolinate synthase; Region: dapA; TIGR00674
395961012519	dimer interface [polypeptide binding]; other site
395961012520	active site
395961012521	catalytic residue [active]
395961012522	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
395961012523	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
395961012524	trigger factor; Region: tig; TIGR00115
395961012525	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
395961012526	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
395961012527	Clp protease; Region: CLP_protease; pfam00574
395961012528	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
395961012529	oligomer interface [polypeptide binding]; other site
395961012530	active site residues [active]
395961012531	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
395961012532	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
395961012533	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961012534	Walker A motif; other site
395961012535	ATP binding site [chemical binding]; other site
395961012536	Walker B motif; other site
395961012537	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
395961012538	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961012539	putative active site [active]
395961012540	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
395961012541	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395961012542	active site
395961012543	metal binding site [ion binding]; metal-binding site
395961012544	DNA binding site [nucleotide binding]
395961012545	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395961012546	Ligand Binding Site [chemical binding]; other site
395961012547	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
395961012548	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
395961012549	dimer interface [polypeptide binding]; other site
395961012550	PYR/PP interface [polypeptide binding]; other site
395961012551	TPP binding site [chemical binding]; other site
395961012552	substrate binding site [chemical binding]; other site
395961012553	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
395961012554	Domain of unknown function; Region: EKR; pfam10371
395961012555	4Fe-4S binding domain; Region: Fer4_6; pfam12837
395961012556	4Fe-4S binding domain; Region: Fer4; pfam00037
395961012557	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
395961012558	TPP-binding site [chemical binding]; other site
395961012559	dimer interface [polypeptide binding]; other site
395961012560	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
395961012561	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
395961012562	putative active site [active]
395961012563	putative FMN binding site [chemical binding]; other site
395961012564	putative substrate binding site [chemical binding]; other site
395961012565	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
395961012566	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
395961012567	dimerization interface [polypeptide binding]; other site
395961012568	DPS ferroxidase diiron center [ion binding]; other site
395961012569	ion pore; other site
395961012570	Response regulator receiver domain; Region: Response_reg; pfam00072
395961012571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961012572	active site
395961012573	phosphorylation site [posttranslational modification]
395961012574	intermolecular recognition site; other site
395961012575	dimerization interface [polypeptide binding]; other site
395961012576	lipoyl synthase; Provisional; Region: PRK12928
395961012577	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961012578	FeS/SAM binding site; other site
395961012579	PsaX family; Region: PsaX; pfam08078
395961012580	Pirin-related protein [General function prediction only]; Region: COG1741
395961012581	Pirin; Region: Pirin; pfam02678
395961012582	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
395961012583	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
395961012584	putative active site; other site
395961012585	catalytic triad [active]
395961012586	putative dimer interface [polypeptide binding]; other site
395961012587	NurA domain; Region: NurA; pfam09376
395961012588	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395961012589	metal binding site 2 [ion binding]; metal-binding site
395961012590	putative DNA binding helix; other site
395961012591	metal binding site 1 [ion binding]; metal-binding site
395961012592	dimer interface [polypeptide binding]; other site
395961012593	structural Zn2+ binding site [ion binding]; other site
395961012594	Repair protein; Region: Repair_PSII; pfam04536
395961012595	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
395961012596	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
395961012597	Bifunctional nuclease; Region: DNase-RNase; pfam02577
395961012598	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
395961012599	Lumazine binding domain; Region: Lum_binding; pfam00677
395961012600	Lumazine binding domain; Region: Lum_binding; pfam00677
395961012601	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
395961012602	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
395961012603	DNA binding site [nucleotide binding]
395961012604	active site
395961012605	Tic22-like family; Region: Tic22; cl04468
395961012606	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395961012607	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395961012608	putative acyl-acceptor binding pocket; other site
395961012609	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
395961012610	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395961012611	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395961012612	Walker A/P-loop; other site
395961012613	ATP binding site [chemical binding]; other site
395961012614	Q-loop/lid; other site
395961012615	ABC transporter signature motif; other site
395961012616	Walker B; other site
395961012617	D-loop; other site
395961012618	H-loop/switch region; other site
395961012619	Esterase/lipase [General function prediction only]; Region: COG1647
395961012620	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395961012621	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961012622	dimer interface [polypeptide binding]; other site
395961012623	conserved gate region; other site
395961012624	putative PBP binding loops; other site
395961012625	ABC-ATPase subunit interface; other site
395961012626	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
395961012627	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
395961012628	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
395961012629	homotetramer interface [polypeptide binding]; other site
395961012630	ligand binding site [chemical binding]; other site
395961012631	catalytic site [active]
395961012632	NAD binding site [chemical binding]; other site
395961012633	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
395961012634	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
395961012635	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961012636	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
395961012637	putative acyl-acceptor binding pocket; other site
395961012638	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
395961012639	RibD C-terminal domain; Region: RibD_C; cl17279
395961012640	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
395961012641	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
395961012642	substrate binding site [chemical binding]; other site
395961012643	active site
395961012644	Response regulator receiver domain; Region: Response_reg; pfam00072
395961012645	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961012646	active site
395961012647	phosphorylation site [posttranslational modification]
395961012648	intermolecular recognition site; other site
395961012649	dimerization interface [polypeptide binding]; other site
395961012650	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961012651	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961012652	ligand binding site [chemical binding]; other site
395961012653	flexible hinge region; other site
395961012654	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395961012655	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961012656	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961012657	ligand binding site [chemical binding]; other site
395961012658	flexible hinge region; other site
395961012659	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395961012660	putative switch regulator; other site
395961012661	non-specific DNA interactions [nucleotide binding]; other site
395961012662	DNA binding site [nucleotide binding]
395961012663	sequence specific DNA binding site [nucleotide binding]; other site
395961012664	putative cAMP binding site [chemical binding]; other site
395961012665	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961012666	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961012667	active site
395961012668	phosphorylation site [posttranslational modification]
395961012669	intermolecular recognition site; other site
395961012670	dimerization interface [polypeptide binding]; other site
395961012671	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961012672	non-specific DNA binding site [nucleotide binding]; other site
395961012673	salt bridge; other site
395961012674	sequence-specific DNA binding site [nucleotide binding]; other site
395961012675	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
395961012676	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012677	putative active site [active]
395961012678	heme pocket [chemical binding]; other site
395961012679	GAF domain; Region: GAF; pfam01590
395961012680	Phytochrome region; Region: PHY; pfam00360
395961012681	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961012682	dimer interface [polypeptide binding]; other site
395961012683	phosphorylation site [posttranslational modification]
395961012684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961012685	ATP binding site [chemical binding]; other site
395961012686	Mg2+ binding site [ion binding]; other site
395961012687	G-X-G motif; other site
395961012688	Response regulator receiver domain; Region: Response_reg; pfam00072
395961012689	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961012690	active site
395961012691	phosphorylation site [posttranslational modification]
395961012692	intermolecular recognition site; other site
395961012693	dimerization interface [polypeptide binding]; other site
395961012694	Response regulator receiver domain; Region: Response_reg; pfam00072
395961012695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961012696	active site
395961012697	phosphorylation site [posttranslational modification]
395961012698	intermolecular recognition site; other site
395961012699	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961012700	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961012701	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012702	PAS fold; Region: PAS_3; pfam08447
395961012703	putative active site [active]
395961012704	heme pocket [chemical binding]; other site
395961012705	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012706	PAS fold; Region: PAS_3; pfam08447
395961012707	heme pocket [chemical binding]; other site
395961012708	putative active site [active]
395961012709	PAS fold; Region: PAS_4; pfam08448
395961012710	PAS domain S-box; Region: sensory_box; TIGR00229
395961012711	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012712	putative active site [active]
395961012713	heme pocket [chemical binding]; other site
395961012714	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012715	PAS domain; Region: PAS_9; pfam13426
395961012716	putative active site [active]
395961012717	heme pocket [chemical binding]; other site
395961012718	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961012719	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961012720	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961012721	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961012722	dimer interface [polypeptide binding]; other site
395961012723	phosphorylation site [posttranslational modification]
395961012724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961012725	ATP binding site [chemical binding]; other site
395961012726	Mg2+ binding site [ion binding]; other site
395961012727	G-X-G motif; other site
395961012728	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961012729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961012730	active site
395961012731	phosphorylation site [posttranslational modification]
395961012732	intermolecular recognition site; other site
395961012733	dimerization interface [polypeptide binding]; other site
395961012734	prephenate dehydratase; Provisional; Region: PRK11898
395961012735	Prephenate dehydratase; Region: PDT; pfam00800
395961012736	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
395961012737	putative L-Phe binding site [chemical binding]; other site
395961012738	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961012739	active site
395961012740	phosphorylation site [posttranslational modification]
395961012741	intermolecular recognition site; other site
395961012742	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012743	PAS fold; Region: PAS_3; pfam08447
395961012744	putative active site [active]
395961012745	heme pocket [chemical binding]; other site
395961012746	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961012747	dimer interface [polypeptide binding]; other site
395961012748	phosphorylation site [posttranslational modification]
395961012749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961012750	ATP binding site [chemical binding]; other site
395961012751	Mg2+ binding site [ion binding]; other site
395961012752	G-X-G motif; other site
395961012753	Response regulator receiver domain; Region: Response_reg; pfam00072
395961012754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961012755	active site
395961012756	phosphorylation site [posttranslational modification]
395961012757	intermolecular recognition site; other site
395961012758	dimerization interface [polypeptide binding]; other site
395961012759	Response regulator receiver domain; Region: Response_reg; pfam00072
395961012760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961012761	active site
395961012762	phosphorylation site [posttranslational modification]
395961012763	intermolecular recognition site; other site
395961012764	dimerization interface [polypeptide binding]; other site
395961012765	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961012766	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961012767	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961012768	dimer interface [polypeptide binding]; other site
395961012769	phosphorylation site [posttranslational modification]
395961012770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961012771	ATP binding site [chemical binding]; other site
395961012772	G-X-G motif; other site
395961012773	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395961012774	catalytic core [active]
395961012775	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
395961012776	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395961012777	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961012778	homodimer interface [polypeptide binding]; other site
395961012779	catalytic residue [active]
395961012780	TPR repeat; Region: TPR_11; pfam13414
395961012781	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961012782	binding surface
395961012783	TPR motif; other site
395961012784	TPR repeat; Region: TPR_11; pfam13414
395961012785	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395961012786	TPR motif; other site
395961012787	binding surface
395961012788	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395961012789	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961012790	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
395961012791	Walker A/P-loop; other site
395961012792	ATP binding site [chemical binding]; other site
395961012793	Q-loop/lid; other site
395961012794	ABC transporter signature motif; other site
395961012795	Walker B; other site
395961012796	D-loop; other site
395961012797	H-loop/switch region; other site
395961012798	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395961012799	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395961012800	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395961012801	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961012802	active site
395961012803	ATP binding site [chemical binding]; other site
395961012804	substrate binding site [chemical binding]; other site
395961012805	activation loop (A-loop); other site
395961012806	phosphoribulokinase; Provisional; Region: PRK07429
395961012807	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
395961012808	active site
395961012809	methionine sulfoxide reductase B; Provisional; Region: PRK00222
395961012810	SelR domain; Region: SelR; pfam01641
395961012811	FOG: CBS domain [General function prediction only]; Region: COG0517
395961012812	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395961012813	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395961012814	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012815	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395961012816	putative active site [active]
395961012817	heme pocket [chemical binding]; other site
395961012818	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961012819	putative active site [active]
395961012820	heme pocket [chemical binding]; other site
395961012821	PAS domain; Region: PAS_9; pfam13426
395961012822	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961012823	Histidine kinase; Region: HisKA_2; pfam07568
395961012824	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961012825	ATP binding site [chemical binding]; other site
395961012826	Mg2+ binding site [ion binding]; other site
395961012827	G-X-G motif; other site
395961012828	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
395961012829	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
395961012830	active site
395961012831	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
395961012832	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395961012833	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395961012834	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961012835	NAD(P) binding site [chemical binding]; other site
395961012836	active site
395961012837	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
395961012838	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961012839	putative active site [active]
395961012840	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
395961012841	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
395961012842	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961012843	dimerization interface [polypeptide binding]; other site
395961012844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961012845	dimer interface [polypeptide binding]; other site
395961012846	phosphorylation site [posttranslational modification]
395961012847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961012848	ATP binding site [chemical binding]; other site
395961012849	Mg2+ binding site [ion binding]; other site
395961012850	G-X-G motif; other site
395961012851	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
395961012852	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
395961012853	FAD binding pocket [chemical binding]; other site
395961012854	FAD binding motif [chemical binding]; other site
395961012855	phosphate binding motif [ion binding]; other site
395961012856	beta-alpha-beta structure motif; other site
395961012857	NAD binding pocket [chemical binding]; other site
395961012858	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395961012859	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395961012860	catalytic loop [active]
395961012861	iron binding site [ion binding]; other site
395961012862	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961012863	binding surface
395961012864	TPR motif; other site
395961012865	TPR repeat; Region: TPR_11; pfam13414
395961012866	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395961012867	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961012868	binding surface
395961012869	TPR motif; other site
395961012870	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
395961012871	dimer interface [polypeptide binding]; other site
395961012872	FMN binding site [chemical binding]; other site
395961012873	cyanophycin synthetase; Provisional; Region: PRK14016
395961012874	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
395961012875	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395961012876	ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...; Region: ASRGL1_like; cd04702
395961012877	catalytic nucleophile [active]
395961012878	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
395961012879	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961012880	non-specific DNA binding site [nucleotide binding]; other site
395961012881	salt bridge; other site
395961012882	sequence-specific DNA binding site [nucleotide binding]; other site
395961012883	Divergent AAA domain; Region: AAA_4; pfam04326
395961012884	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
395961012885	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
395961012886	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395961012887	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395961012888	catalytic loop [active]
395961012889	iron binding site [ion binding]; other site
395961012890	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
395961012891	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
395961012892	G1 box; other site
395961012893	GTP/Mg2+ binding site [chemical binding]; other site
395961012894	Switch I region; other site
395961012895	G2 box; other site
395961012896	Switch II region; other site
395961012897	G3 box; other site
395961012898	G4 box; other site
395961012899	G5 box; other site
395961012900	Domain of unknown function (DUF697); Region: DUF697; pfam05128
395961012901	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395961012902	dimerization interface [polypeptide binding]; other site
395961012903	putative DNA binding site [nucleotide binding]; other site
395961012904	putative Zn2+ binding site [ion binding]; other site
395961012905	cytochrome c biogenesis protein; Region: ccsA; CHL00045
395961012906	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
395961012907	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
395961012908	DXD motif; other site
395961012909	hypothetical protein; Provisional; Region: PRK07208
395961012910	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395961012911	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
395961012912	30S subunit binding site; other site
395961012913	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
395961012914	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
395961012915	active site
395961012916	dimerization interface [polypeptide binding]; other site
395961012917	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
395961012918	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
395961012919	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
395961012920	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
395961012921	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
395961012922	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
395961012923	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
395961012924	trimerization site [polypeptide binding]; other site
395961012925	active site
395961012926	Protein of function (DUF2518); Region: DUF2518; pfam10726
395961012927	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
395961012928	DEAD-like helicases superfamily; Region: DEXDc; smart00487
395961012929	ATP binding site [chemical binding]; other site
395961012930	Mg++ binding site [ion binding]; other site
395961012931	motif III; other site
395961012932	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961012933	nucleotide binding region [chemical binding]; other site
395961012934	ATP-binding site [chemical binding]; other site
395961012935	PPP4R2; Region: PPP4R2; pfam09184
395961012936	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
395961012937	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
395961012938	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
395961012939	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
395961012940	phosphate acetyltransferase; Reviewed; Region: PRK05632
395961012941	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961012942	DRTGG domain; Region: DRTGG; pfam07085
395961012943	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
395961012944	Uncharacterized conserved protein [Function unknown]; Region: COG2454
395961012945	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
395961012946	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
395961012947	Predicted esterase [General function prediction only]; Region: COG0400
395961012948	putative hydrolase; Provisional; Region: PRK11460
395961012949	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
395961012950	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
395961012951	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
395961012952	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
395961012953	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
395961012954	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
395961012955	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
395961012956	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
395961012957	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
395961012958	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
395961012959	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
395961012960	glutamine binding [chemical binding]; other site
395961012961	catalytic triad [active]
395961012962	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
395961012963	metal-binding heat shock protein; Provisional; Region: PRK00016
395961012964	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
395961012965	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
395961012966	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
395961012967	ATP binding site [chemical binding]; other site
395961012968	active site
395961012969	substrate binding site [chemical binding]; other site
395961012970	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395961012971	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
395961012972	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395961012973	Surface antigen; Region: Bac_surface_Ag; pfam01103
395961012974	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
395961012975	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
395961012976	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
395961012977	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
395961012978	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
395961012979	active site
395961012980	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
395961012981	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
395961012982	Double zinc ribbon; Region: DZR; pfam12773
395961012983	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
395961012984	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
395961012985	active site
395961012986	Exoribonuclease R [Transcription]; Region: VacB; COG0557
395961012987	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
395961012988	RNB domain; Region: RNB; pfam00773
395961012989	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
395961012990	RNA binding site [nucleotide binding]; other site
395961012991	acyl carrier protein; Provisional; Region: acpP; PRK00982
395961012992	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
395961012993	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395961012994	dimer interface [polypeptide binding]; other site
395961012995	active site
395961012996	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
395961012997	TPP-binding site [chemical binding]; other site
395961012998	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
395961012999	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
395961013000	PYR/PP interface [polypeptide binding]; other site
395961013001	dimer interface [polypeptide binding]; other site
395961013002	TPP binding site [chemical binding]; other site
395961013003	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395961013004	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
395961013005	trimer interface [polypeptide binding]; other site
395961013006	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395961013007	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961013008	binding surface
395961013009	TPR motif; other site
395961013010	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961013011	binding surface
395961013012	TPR motif; other site
395961013013	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961013014	binding surface
395961013015	TPR motif; other site
395961013016	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961013017	Amino acid permease; Region: AA_permease_2; pfam13520
395961013018	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
395961013019	transketolase; Region: PLN02790
395961013020	TPP-binding site [chemical binding]; other site
395961013021	dimer interface [polypeptide binding]; other site
395961013022	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
395961013023	PYR/PP interface [polypeptide binding]; other site
395961013024	dimer interface [polypeptide binding]; other site
395961013025	TPP binding site [chemical binding]; other site
395961013026	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395961013027	photosystem II reaction center protein Psb28; Provisional; Region: PRK13612
395961013028	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
395961013029	MPT binding site; other site
395961013030	trimer interface [polypeptide binding]; other site
395961013031	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
395961013032	C-terminal peptidase (prc); Region: prc; TIGR00225
395961013033	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
395961013034	protein binding site [polypeptide binding]; other site
395961013035	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
395961013036	Catalytic dyad [active]
395961013037	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
395961013038	active site
395961013039	catalytic residues [active]
395961013040	DNA binding site [nucleotide binding]
395961013041	Int/Topo IB signature motif; other site
395961013042	ferrochelatase; Reviewed; Region: hemH; PRK00035
395961013043	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
395961013044	C-terminal domain interface [polypeptide binding]; other site
395961013045	active site
395961013046	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
395961013047	active site
395961013048	N-terminal domain interface [polypeptide binding]; other site
395961013049	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
395961013050	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
395961013051	Protein of unknown function, DUF608; Region: DUF608; pfam04685
395961013052	Uncharacterized conserved protein [Function unknown]; Region: COG2442
395961013053	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961013054	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
395961013055	HNH endonuclease; Region: HNH_4; pfam13395
395961013056	Protein of unknown function DUF104; Region: DUF104; pfam01954
395961013057	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395961013058	Sulfatase; Region: Sulfatase; pfam00884
395961013059	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
395961013060	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
395961013061	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
395961013062	B12 binding site [chemical binding]; other site
395961013063	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961013064	FeS/SAM binding site; other site
395961013065	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
395961013066	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
395961013067	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
395961013068	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
395961013069	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395961013070	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395961013071	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395961013072	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013073	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961013074	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013075	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961013076	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013077	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013078	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961013080	ATP binding site [chemical binding]; other site
395961013081	G-X-G motif; other site
395961013082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013083	active site
395961013084	phosphorylation site [posttranslational modification]
395961013085	intermolecular recognition site; other site
395961013086	dimerization interface [polypeptide binding]; other site
395961013087	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
395961013088	DHH family; Region: DHH; pfam01368
395961013089	DHHA1 domain; Region: DHHA1; pfam02272
395961013090	hypothetical protein; Provisional; Region: PRK13686
395961013091	Flagellin N-methylase; Region: FliB; pfam03692
395961013092	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961013093	putative active site [active]
395961013094	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
395961013095	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
395961013096	active site
395961013097	metal binding site [ion binding]; metal-binding site
395961013098	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961013099	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961013100	Putative restriction endonuclease; Region: Uma2; pfam05685
395961013101	putative active site [active]
395961013102	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
395961013103	active site
395961013104	hydrophilic channel; other site
395961013105	dimerization interface [polypeptide binding]; other site
395961013106	catalytic residues [active]
395961013107	active site lid [active]
395961013108	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395961013109	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395961013110	Walker A/P-loop; other site
395961013111	ATP binding site [chemical binding]; other site
395961013112	Q-loop/lid; other site
395961013113	ABC transporter signature motif; other site
395961013114	Walker B; other site
395961013115	D-loop; other site
395961013116	H-loop/switch region; other site
395961013117	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
395961013118	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
395961013119	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961013120	dimer interface [polypeptide binding]; other site
395961013121	conserved gate region; other site
395961013122	putative PBP binding loops; other site
395961013123	ABC-ATPase subunit interface; other site
395961013124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961013125	dimer interface [polypeptide binding]; other site
395961013126	conserved gate region; other site
395961013127	putative PBP binding loops; other site
395961013128	ABC-ATPase subunit interface; other site
395961013129	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
395961013130	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395961013131	active site
395961013132	ATP binding site [chemical binding]; other site
395961013133	substrate binding site [chemical binding]; other site
395961013134	activation loop (A-loop); other site
395961013135	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961013136	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013137	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013138	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395961013139	Zn2+ binding site [ion binding]; other site
395961013140	Mg2+ binding site [ion binding]; other site
395961013141	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
395961013142	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395961013143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013144	active site
395961013145	phosphorylation site [posttranslational modification]
395961013146	intermolecular recognition site; other site
395961013147	dimerization interface [polypeptide binding]; other site
395961013148	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395961013149	DNA binding residues [nucleotide binding]
395961013150	dimerization interface [polypeptide binding]; other site
395961013151	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013152	active site
395961013153	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961013154	phosphorylation site [posttranslational modification]
395961013155	intermolecular recognition site; other site
395961013156	dimerization interface [polypeptide binding]; other site
395961013157	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
395961013158	dimer interface [polypeptide binding]; other site
395961013159	phosphorylation site [posttranslational modification]
395961013160	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961013161	ATP binding site [chemical binding]; other site
395961013162	Mg2+ binding site [ion binding]; other site
395961013163	G-X-G motif; other site
395961013164	L-asparaginase II; Region: Asparaginase_II; cl01842
395961013165	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
395961013166	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
395961013167	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
395961013168	dimer interface [polypeptide binding]; other site
395961013169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961013170	catalytic residue [active]
395961013171	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
395961013172	transcriptional regulator NarL; Provisional; Region: PRK10651
395961013173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013174	active site
395961013175	phosphorylation site [posttranslational modification]
395961013176	intermolecular recognition site; other site
395961013177	dimerization interface [polypeptide binding]; other site
395961013178	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395961013179	DNA binding residues [nucleotide binding]
395961013180	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395961013181	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395961013182	HlyD family secretion protein; Region: HlyD_3; pfam13437
395961013183	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395961013184	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395961013185	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395961013186	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961013187	Coenzyme A binding pocket [chemical binding]; other site
395961013188	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395961013189	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
395961013190	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
395961013191	[4Fe-4S] binding site [ion binding]; other site
395961013192	molybdopterin cofactor binding site; other site
395961013193	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
395961013194	molybdopterin cofactor binding site; other site
395961013195	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
395961013196	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
395961013197	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395961013198	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
395961013199	Walker A/P-loop; other site
395961013200	ATP binding site [chemical binding]; other site
395961013201	Q-loop/lid; other site
395961013202	ABC transporter signature motif; other site
395961013203	Walker B; other site
395961013204	D-loop; other site
395961013205	H-loop/switch region; other site
395961013206	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395961013207	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
395961013208	Walker A/P-loop; other site
395961013209	ATP binding site [chemical binding]; other site
395961013210	Q-loop/lid; other site
395961013211	ABC transporter signature motif; other site
395961013212	Walker B; other site
395961013213	D-loop; other site
395961013214	H-loop/switch region; other site
395961013215	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395961013216	NMT1-like family; Region: NMT1_2; pfam13379
395961013217	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395961013218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961013219	dimer interface [polypeptide binding]; other site
395961013220	conserved gate region; other site
395961013221	putative PBP binding loops; other site
395961013222	ABC-ATPase subunit interface; other site
395961013223	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395961013224	NMT1-like family; Region: NMT1_2; pfam13379
395961013225	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
395961013226	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395961013227	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395961013228	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
395961013229	Y-family of DNA polymerases; Region: PolY; cl12025
395961013230	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
395961013231	generic binding surface II; other site
395961013232	ssDNA binding site; other site
395961013233	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961013234	ATP binding site [chemical binding]; other site
395961013235	putative Mg++ binding site [ion binding]; other site
395961013236	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961013237	nucleotide binding region [chemical binding]; other site
395961013238	ATP-binding site [chemical binding]; other site
395961013239	polyphosphate kinase; Provisional; Region: PRK05443
395961013240	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
395961013241	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
395961013242	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
395961013243	putative domain interface [polypeptide binding]; other site
395961013244	putative active site [active]
395961013245	catalytic site [active]
395961013246	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
395961013247	putative domain interface [polypeptide binding]; other site
395961013248	putative active site [active]
395961013249	catalytic site [active]
395961013250	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
395961013251	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961013252	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961013253	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395961013254	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
395961013255	Clp amino terminal domain; Region: Clp_N; pfam02861
395961013256	Clp amino terminal domain; Region: Clp_N; pfam02861
395961013257	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961013258	Walker A motif; other site
395961013259	ATP binding site [chemical binding]; other site
395961013260	Walker B motif; other site
395961013261	arginine finger; other site
395961013262	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961013263	Walker A motif; other site
395961013264	ATP binding site [chemical binding]; other site
395961013265	Walker B motif; other site
395961013266	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
395961013267	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
395961013268	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961013269	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961013270	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
395961013271	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
395961013272	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
395961013273	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
395961013274	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
395961013275	active site
395961013276	motif I; other site
395961013277	motif II; other site
395961013278	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961013279	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
395961013280	putative ADP-binding pocket [chemical binding]; other site
395961013281	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
395961013282	putative catalytic site [active]
395961013283	putative phosphate binding site [ion binding]; other site
395961013284	active site
395961013285	metal binding site A [ion binding]; metal-binding site
395961013286	DNA binding site [nucleotide binding]
395961013287	putative AP binding site [nucleotide binding]; other site
395961013288	putative metal binding site B [ion binding]; other site
395961013289	Fatty acid desaturase; Region: FA_desaturase; pfam00487
395961013290	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
395961013291	Di-iron ligands [ion binding]; other site
395961013292	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395961013293	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961013294	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395961013295	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
395961013296	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
395961013297	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
395961013298	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961013299	active site
395961013300	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
395961013301	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
395961013302	PIN domain; Region: PIN_3; pfam13470
395961013303	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961013304	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
395961013305	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
395961013306	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
395961013307	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961013308	GAF domain; Region: GAF; pfam01590
395961013309	PAS domain S-box; Region: sensory_box; TIGR00229
395961013310	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961013311	putative active site [active]
395961013312	heme pocket [chemical binding]; other site
395961013313	PAS domain S-box; Region: sensory_box; TIGR00229
395961013314	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961013315	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961013316	PAS domain S-box; Region: sensory_box; TIGR00229
395961013317	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961013318	GAF domain; Region: GAF; pfam01590
395961013319	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961013320	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961013321	dimer interface [polypeptide binding]; other site
395961013322	phosphorylation site [posttranslational modification]
395961013323	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961013324	ATP binding site [chemical binding]; other site
395961013325	Mg2+ binding site [ion binding]; other site
395961013326	G-X-G motif; other site
395961013327	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961013328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013329	active site
395961013330	phosphorylation site [posttranslational modification]
395961013331	intermolecular recognition site; other site
395961013332	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961013333	dimerization interface [polypeptide binding]; other site
395961013334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961013335	dimer interface [polypeptide binding]; other site
395961013336	phosphorylation site [posttranslational modification]
395961013337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961013338	ATP binding site [chemical binding]; other site
395961013339	Mg2+ binding site [ion binding]; other site
395961013340	G-X-G motif; other site
395961013341	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
395961013342	GAF domain; Region: GAF_3; pfam13492
395961013343	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961013344	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961013345	dimer interface [polypeptide binding]; other site
395961013346	phosphorylation site [posttranslational modification]
395961013347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961013348	ATP binding site [chemical binding]; other site
395961013349	Mg2+ binding site [ion binding]; other site
395961013350	G-X-G motif; other site
395961013351	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013352	active site
395961013353	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961013354	phosphorylation site [posttranslational modification]
395961013355	intermolecular recognition site; other site
395961013356	dimerization interface [polypeptide binding]; other site
395961013357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961013358	dimer interface [polypeptide binding]; other site
395961013359	phosphorylation site [posttranslational modification]
395961013360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961013361	ATP binding site [chemical binding]; other site
395961013362	Mg2+ binding site [ion binding]; other site
395961013363	G-X-G motif; other site
395961013364	PAS fold; Region: PAS; pfam00989
395961013365	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961013366	putative active site [active]
395961013367	heme pocket [chemical binding]; other site
395961013368	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961013369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013370	active site
395961013371	phosphorylation site [posttranslational modification]
395961013372	intermolecular recognition site; other site
395961013373	dimerization interface [polypeptide binding]; other site
395961013374	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
395961013375	putative FMN binding site [chemical binding]; other site
395961013376	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
395961013377	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961013378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013379	active site
395961013380	phosphorylation site [posttranslational modification]
395961013381	intermolecular recognition site; other site
395961013382	dimerization interface [polypeptide binding]; other site
395961013383	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961013384	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961013385	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961013386	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961013387	dimer interface [polypeptide binding]; other site
395961013388	phosphorylation site [posttranslational modification]
395961013389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961013390	ATP binding site [chemical binding]; other site
395961013391	Mg2+ binding site [ion binding]; other site
395961013392	G-X-G motif; other site
395961013393	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961013394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013395	active site
395961013396	phosphorylation site [posttranslational modification]
395961013397	intermolecular recognition site; other site
395961013398	dimerization interface [polypeptide binding]; other site
395961013399	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395961013400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961013401	dimer interface [polypeptide binding]; other site
395961013402	conserved gate region; other site
395961013403	putative PBP binding loops; other site
395961013404	ABC-ATPase subunit interface; other site
395961013405	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
395961013406	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
395961013407	C-terminal domain interface [polypeptide binding]; other site
395961013408	active site
395961013409	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
395961013410	active site
395961013411	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961013412	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013413	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013414	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
395961013415	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
395961013416	putative catalytic site [active]
395961013417	putative metal binding site [ion binding]; other site
395961013418	putative phosphate binding site [ion binding]; other site
395961013419	SnoaL-like domain; Region: SnoaL_3; pfam13474
395961013420	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
395961013421	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
395961013422	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
395961013423	active site
395961013424	ADP/pyrophosphate binding site [chemical binding]; other site
395961013425	dimerization interface [polypeptide binding]; other site
395961013426	allosteric effector site; other site
395961013427	fructose-1,6-bisphosphate binding site; other site
395961013428	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395961013429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013430	active site
395961013431	phosphorylation site [posttranslational modification]
395961013432	intermolecular recognition site; other site
395961013433	dimerization interface [polypeptide binding]; other site
395961013434	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395961013435	DNA binding residues [nucleotide binding]
395961013436	dimerization interface [polypeptide binding]; other site
395961013437	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
395961013438	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
395961013439	catalytic motif [active]
395961013440	Catalytic residue [active]
395961013441	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395961013442	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395961013443	active site
395961013444	catalytic tetrad [active]
395961013445	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961013446	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395961013447	putative substrate translocation pore; other site
395961013448	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
395961013449	putative nucleotide binding site [chemical binding]; other site
395961013450	uridine monophosphate binding site [chemical binding]; other site
395961013451	homohexameric interface [polypeptide binding]; other site
395961013452	ribosome recycling factor; Reviewed; Region: frr; PRK00083
395961013453	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
395961013454	hinge region; other site
395961013455	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
395961013456	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
395961013457	Mrr N-terminal domain; Region: Mrr_N; pfam14338
395961013458	Restriction endonuclease; Region: Mrr_cat; pfam04471
395961013459	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
395961013460	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395961013461	RNA binding surface [nucleotide binding]; other site
395961013462	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
395961013463	active site
395961013464	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961013465	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
395961013466	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
395961013467	seryl-tRNA synthetase; Provisional; Region: PRK05431
395961013468	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
395961013469	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
395961013470	dimer interface [polypeptide binding]; other site
395961013471	active site
395961013472	motif 1; other site
395961013473	motif 2; other site
395961013474	motif 3; other site
395961013475	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
395961013476	putative active site [active]
395961013477	YwiC-like protein; Region: YwiC; pfam14256
395961013478	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
395961013479	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
395961013480	Hemerythrin-like domain; Region: Hr-like; cd12108
395961013481	Fe binding site [ion binding]; other site
395961013482	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
395961013483	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395961013484	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
395961013485	dimerization interface [polypeptide binding]; other site
395961013486	substrate binding pocket [chemical binding]; other site
395961013487	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395961013488	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395961013489	Coenzyme A binding pocket [chemical binding]; other site
395961013490	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961013491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961013492	S-adenosylmethionine binding site [chemical binding]; other site
395961013493	enterobactin exporter EntS; Provisional; Region: PRK10489
395961013494	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961013495	putative substrate translocation pore; other site
395961013496	HEAT repeats; Region: HEAT_2; pfam13646
395961013497	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
395961013498	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
395961013499	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
395961013500	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
395961013501	putative active site [active]
395961013502	putative metal binding site [ion binding]; other site
395961013503	hypothetical protein; Provisional; Region: PRK08317
395961013504	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961013505	S-adenosylmethionine binding site [chemical binding]; other site
395961013506	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
395961013507	L-type amino acid transporter; Region: 2A0308; TIGR00911
395961013508	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961013509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961013510	S-adenosylmethionine binding site [chemical binding]; other site
395961013511	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961013512	dimer interface [polypeptide binding]; other site
395961013513	conserved gate region; other site
395961013514	ABC-ATPase subunit interface; other site
395961013515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961013516	dimer interface [polypeptide binding]; other site
395961013517	conserved gate region; other site
395961013518	ABC-ATPase subunit interface; other site
395961013519	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
395961013520	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
395961013521	Cache domain; Region: Cache_1; pfam02743
395961013522	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961013523	dimerization interface [polypeptide binding]; other site
395961013524	PAS domain S-box; Region: sensory_box; TIGR00229
395961013525	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961013526	putative active site [active]
395961013527	heme pocket [chemical binding]; other site
395961013528	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
395961013529	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395961013530	substrate binding pocket [chemical binding]; other site
395961013531	membrane-bound complex binding site; other site
395961013532	hinge residues; other site
395961013533	Hemerythrin; Region: Hemerythrin; cd12107
395961013534	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
395961013535	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
395961013536	photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056
395961013537	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
395961013538	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395961013539	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
395961013540	substrate binding site [chemical binding]; other site
395961013541	oxyanion hole (OAH) forming residues; other site
395961013542	trimer interface [polypeptide binding]; other site
395961013543	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395961013544	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395961013545	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
395961013546	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
395961013547	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
395961013548	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
395961013549	Walker A/P-loop; other site
395961013550	ATP binding site [chemical binding]; other site
395961013551	Q-loop/lid; other site
395961013552	ABC transporter signature motif; other site
395961013553	Walker B; other site
395961013554	D-loop; other site
395961013555	H-loop/switch region; other site
395961013556	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
395961013557	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
395961013558	Walker A/P-loop; other site
395961013559	ATP binding site [chemical binding]; other site
395961013560	Q-loop/lid; other site
395961013561	ABC transporter signature motif; other site
395961013562	Walker B; other site
395961013563	D-loop; other site
395961013564	H-loop/switch region; other site
395961013565	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
395961013566	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395961013567	HlyD family secretion protein; Region: HlyD_3; pfam13437
395961013568	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395961013569	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961013570	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
395961013571	RuvA N terminal domain; Region: RuvA_N; pfam01330
395961013572	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
395961013573	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
395961013574	DNA polymerase III subunit delta; Validated; Region: PRK07452
395961013575	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
395961013576	Predicted membrane protein [Function unknown]; Region: COG2119
395961013577	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
395961013578	Predicted membrane protein [Function unknown]; Region: COG2119
395961013579	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
395961013580	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
395961013581	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
395961013582	metal binding site [ion binding]; metal-binding site
395961013583	dimer interface [polypeptide binding]; other site
395961013584	Uncharacterized conserved protein [Function unknown]; Region: COG1432
395961013585	LabA_like proteins; Region: LabA; cd10911
395961013586	putative metal binding site [ion binding]; other site
395961013587	Uncharacterized conserved protein [Function unknown]; Region: COG1434
395961013588	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
395961013589	putative active site [active]
395961013590	GTPase RsgA; Reviewed; Region: PRK12289
395961013591	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
395961013592	RNA binding site [nucleotide binding]; other site
395961013593	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
395961013594	GTPase/Zn-binding domain interface [polypeptide binding]; other site
395961013595	GTP/Mg2+ binding site [chemical binding]; other site
395961013596	G4 box; other site
395961013597	G5 box; other site
395961013598	G1 box; other site
395961013599	Switch I region; other site
395961013600	G2 box; other site
395961013601	G3 box; other site
395961013602	Switch II region; other site
395961013603	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
395961013604	CPxP  motif; other site
395961013605	chaperone protein DnaJ; Provisional; Region: PRK14293
395961013606	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395961013607	HSP70 interaction site [polypeptide binding]; other site
395961013608	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
395961013609	substrate binding site [polypeptide binding]; other site
395961013610	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
395961013611	Zn binding sites [ion binding]; other site
395961013612	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
395961013613	dimer interface [polypeptide binding]; other site
395961013614	molecular chaperone DnaK; Provisional; Region: PRK13411
395961013615	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
395961013616	nucleotide binding site [chemical binding]; other site
395961013617	NEF interaction site [polypeptide binding]; other site
395961013618	SBD interface [polypeptide binding]; other site
395961013619	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
395961013620	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
395961013621	dimer interface [polypeptide binding]; other site
395961013622	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
395961013623	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
395961013624	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
395961013625	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
395961013626	Walker A motif; other site
395961013627	ATP binding site [chemical binding]; other site
395961013628	Walker B motif; other site
395961013629	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
395961013630	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
395961013631	Walker A motif; other site
395961013632	ATP binding site [chemical binding]; other site
395961013633	Walker B motif; other site
395961013634	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
395961013635	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
395961013636	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
395961013637	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
395961013638	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395961013639	HSP70 interaction site [polypeptide binding]; other site
395961013640	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
395961013641	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
395961013642	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
395961013643	catalytic residue [active]
395961013644	putative FPP diphosphate  binding site; other site
395961013645	putative FPP binding hydrophobic cleft; other site
395961013646	dimer interface [polypeptide binding]; other site
395961013647	putative IPP diphosphate binding site; other site
395961013648	TIGR00159 family protein; Region: TIGR00159
395961013649	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
395961013650	diaminopimelate decarboxylase; Region: lysA; TIGR01048
395961013651	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
395961013652	active site
395961013653	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395961013654	substrate binding site [chemical binding]; other site
395961013655	catalytic residues [active]
395961013656	dimer interface [polypeptide binding]; other site
395961013657	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
395961013658	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395961013659	Clp protease ATP binding subunit; Region: clpC; CHL00095
395961013660	Clp amino terminal domain; Region: Clp_N; pfam02861
395961013661	Clp amino terminal domain; Region: Clp_N; pfam02861
395961013662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961013663	Walker A motif; other site
395961013664	ATP binding site [chemical binding]; other site
395961013665	Walker B motif; other site
395961013666	arginine finger; other site
395961013667	UvrB/uvrC motif; Region: UVR; pfam02151
395961013668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961013669	Walker A motif; other site
395961013670	ATP binding site [chemical binding]; other site
395961013671	Walker B motif; other site
395961013672	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
395961013673	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
395961013674	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
395961013675	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
395961013676	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
395961013677	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
395961013678	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
395961013679	Predicted membrane protein (DUF2243); Region: DUF2243; cl01783
395961013680	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
395961013681	GUN4-like; Region: GUN4; pfam05419
395961013682	N-terminal domain of RfaE; Region: RfaE_N; cd02172
395961013683	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
395961013684	putative active site [active]
395961013685	(T/H)XGH motif; other site
395961013686	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
395961013687	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
395961013688	putative catalytic cysteine [active]
395961013689	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
395961013690	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395961013691	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
395961013692	nucleoside/Zn binding site; other site
395961013693	dimer interface [polypeptide binding]; other site
395961013694	catalytic motif [active]
395961013695	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961013696	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013697	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961013698	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013699	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013700	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013701	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013702	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961013703	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
395961013704	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
395961013705	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
395961013706	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
395961013707	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961013708	dimer interface [polypeptide binding]; other site
395961013709	conserved gate region; other site
395961013710	putative PBP binding loops; other site
395961013711	ABC-ATPase subunit interface; other site
395961013712	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
395961013713	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
395961013714	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961013715	catalytic residue [active]
395961013716	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
395961013717	phosphoenolpyruvate synthase; Validated; Region: PRK06241
395961013718	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
395961013719	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
395961013720	AMIN domain; Region: AMIN; pfam11741
395961013721	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
395961013722	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
395961013723	active site
395961013724	metal binding site [ion binding]; metal-binding site
395961013725	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
395961013726	putative GSH binding site [chemical binding]; other site
395961013727	catalytic residues [active]
395961013728	BolA-like protein; Region: BolA; pfam01722
395961013729	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
395961013730	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
395961013731	cell division protein FtsZ; Validated; Region: PRK09330
395961013732	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
395961013733	nucleotide binding site [chemical binding]; other site
395961013734	SulA interaction site; other site
395961013735	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
395961013736	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
395961013737	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395961013738	active site
395961013739	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395961013740	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
395961013741	FtsX-like permease family; Region: FtsX; pfam02687
395961013742	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395961013743	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395961013744	HlyD family secretion protein; Region: HlyD_3; pfam13437
395961013745	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
395961013746	Short C-terminal domain; Region: SHOCT; pfam09851
395961013747	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
395961013748	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
395961013749	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
395961013750	Response regulator receiver domain; Region: Response_reg; pfam00072
395961013751	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013752	active site
395961013753	phosphorylation site [posttranslational modification]
395961013754	intermolecular recognition site; other site
395961013755	dimerization interface [polypeptide binding]; other site
395961013756	Response regulator receiver domain; Region: Response_reg; pfam00072
395961013757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013758	active site
395961013759	phosphorylation site [posttranslational modification]
395961013760	intermolecular recognition site; other site
395961013761	dimerization interface [polypeptide binding]; other site
395961013762	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
395961013763	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
395961013764	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
395961013765	dimerization interface [polypeptide binding]; other site
395961013766	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395961013767	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395961013768	dimer interface [polypeptide binding]; other site
395961013769	putative CheW interface [polypeptide binding]; other site
395961013770	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
395961013771	putative binding surface; other site
395961013772	active site
395961013773	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
395961013774	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961013775	ATP binding site [chemical binding]; other site
395961013776	Mg2+ binding site [ion binding]; other site
395961013777	G-X-G motif; other site
395961013778	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
395961013779	Response regulator receiver domain; Region: Response_reg; pfam00072
395961013780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013781	active site
395961013782	phosphorylation site [posttranslational modification]
395961013783	intermolecular recognition site; other site
395961013784	dimerization interface [polypeptide binding]; other site
395961013785	hypothetical protein; Provisional; Region: PRK08317
395961013786	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961013787	S-adenosylmethionine binding site [chemical binding]; other site
395961013788	lipoyl synthase; Provisional; Region: PRK05481
395961013789	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961013790	FeS/SAM binding site; other site
395961013791	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961013792	putative active site [active]
395961013793	FOG: CBS domain [General function prediction only]; Region: COG0517
395961013794	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395961013795	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
395961013796	homotrimer interaction site [polypeptide binding]; other site
395961013797	active site
395961013798	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
395961013799	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
395961013800	tandem repeat interface [polypeptide binding]; other site
395961013801	oligomer interface [polypeptide binding]; other site
395961013802	active site residues [active]
395961013803	Putative addiction module component; Region: Unstab_antitox; pfam09720
395961013804	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
395961013805	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
395961013806	YCII-related domain; Region: YCII; cl00999
395961013807	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
395961013808	HD domain; Region: HD_4; pfam13328
395961013809	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
395961013810	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
395961013811	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
395961013812	ligand binding site; other site
395961013813	oligomer interface; other site
395961013814	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961013815	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
395961013816	dimer interface [polypeptide binding]; other site
395961013817	N-terminal domain interface [polypeptide binding]; other site
395961013818	sulfate 1 binding site; other site
395961013819	GAF domain; Region: GAF_3; pfam13492
395961013820	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
395961013821	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
395961013822	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
395961013823	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
395961013824	active site
395961013825	Predicted GTPase [General function prediction only]; Region: COG3596
395961013826	YfjP GTPase; Region: YfjP; cd11383
395961013827	G1 box; other site
395961013828	GTP/Mg2+ binding site [chemical binding]; other site
395961013829	Switch I region; other site
395961013830	G2 box; other site
395961013831	Switch II region; other site
395961013832	G3 box; other site
395961013833	G4 box; other site
395961013834	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961013835	non-specific DNA binding site [nucleotide binding]; other site
395961013836	salt bridge; other site
395961013837	sequence-specific DNA binding site [nucleotide binding]; other site
395961013838	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
395961013839	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
395961013840	AMIN domain; Region: AMIN; pfam11741
395961013841	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
395961013842	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
395961013843	Late competence development protein ComFB; Region: ComFB; pfam10719
395961013844	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
395961013845	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
395961013846	Fatty acid desaturase; Region: FA_desaturase; pfam00487
395961013847	Di-iron ligands [ion binding]; other site
395961013848	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
395961013849	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
395961013850	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961013851	FeS/SAM binding site; other site
395961013852	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961013853	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395961013854	active site
395961013855	phosphorylation site [posttranslational modification]
395961013856	intermolecular recognition site; other site
395961013857	dimerization interface [polypeptide binding]; other site
395961013858	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
395961013859	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961013860	FeS/SAM binding site; other site
395961013861	HemN C-terminal domain; Region: HemN_C; pfam06969
395961013862	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
395961013863	heme binding pocket [chemical binding]; other site
395961013864	heme ligand [chemical binding]; other site
395961013865	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
395961013866	diiron binding motif [ion binding]; other site
395961013867	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
395961013868	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
395961013869	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
395961013870	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395961013871	WD40 repeats; Region: WD40; smart00320
395961013872	WD40 repeats; Region: WD40; smart00320
395961013873	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961013874	structural tetrad; other site
395961013875	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395961013876	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961013877	structural tetrad; other site
395961013878	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
395961013879	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
395961013880	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
395961013881	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
395961013882	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
395961013883	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
395961013884	trimer interface [polypeptide binding]; other site
395961013885	active site
395961013886	substrate binding site [chemical binding]; other site
395961013887	CoA binding site [chemical binding]; other site
395961013888	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
395961013889	Ferritin-like domain; Region: Ferritin; pfam00210
395961013890	dimerization interface [polypeptide binding]; other site
395961013891	DPS ferroxidase diiron center [ion binding]; other site
395961013892	ion pore; other site
395961013893	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
395961013894	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
395961013895	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
395961013896	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
395961013897	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
395961013898	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
395961013899	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
395961013900	Protein of unknown function, DUF269; Region: DUF269; pfam03270
395961013901	Rop-like; Region: Rop-like; pfam05082
395961013902	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102
395961013903	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
395961013904	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
395961013905	ATP binding site [chemical binding]; other site
395961013906	substrate interface [chemical binding]; other site
395961013907	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
395961013908	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395961013909	catalytic loop [active]
395961013910	iron binding site [ion binding]; other site
395961013911	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
395961013912	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
395961013913	putative catalytic residues [active]
395961013914	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961013915	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961013916	S-adenosylmethionine binding site [chemical binding]; other site
395961013917	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961013918	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961013919	metal binding site [ion binding]; metal-binding site
395961013920	active site
395961013921	I-site; other site
395961013922	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
395961013923	Aluminium resistance protein; Region: Alum_res; pfam06838
395961013924	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
395961013925	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
395961013926	Fatty acid desaturase; Region: FA_desaturase; pfam00487
395961013927	Di-iron ligands [ion binding]; other site
395961013928	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
395961013929	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
395961013930	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
395961013931	TrkA-N domain; Region: TrkA_N; pfam02254
395961013932	TrkA-C domain; Region: TrkA_C; pfam02080
395961013933	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
395961013934	TrkA-N domain; Region: TrkA_N; pfam02254
395961013935	TrkA-C domain; Region: TrkA_C; pfam02080
395961013936	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
395961013937	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
395961013938	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
395961013939	dimerization interface [polypeptide binding]; other site
395961013940	putative active cleft [active]
395961013941	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
395961013942	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
395961013943	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
395961013944	homodimer interface [polypeptide binding]; other site
395961013945	Walker A motif; other site
395961013946	ATP binding site [chemical binding]; other site
395961013947	hydroxycobalamin binding site [chemical binding]; other site
395961013948	Walker B motif; other site
395961013949	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395961013950	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
395961013951	putative dimer interface [polypeptide binding]; other site
395961013952	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
395961013953	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
395961013954	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
395961013955	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
395961013956	active site lid residues [active]
395961013957	substrate binding pocket [chemical binding]; other site
395961013958	catalytic residues [active]
395961013959	substrate-Mg2+ binding site; other site
395961013960	aspartate-rich region 1; other site
395961013961	aspartate-rich region 2; other site
395961013962	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
395961013963	HEAT repeats; Region: HEAT_2; pfam13646
395961013964	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
395961013965	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
395961013966	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
395961013967	NAD binding site [chemical binding]; other site
395961013968	homodimer interface [polypeptide binding]; other site
395961013969	active site
395961013970	substrate binding site [chemical binding]; other site
395961013971	glutathione synthetase; Provisional; Region: PRK05246
395961013972	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
395961013973	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
395961013974	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
395961013975	GSH binding site [chemical binding]; other site
395961013976	catalytic residues [active]
395961013977	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395961013978	Beta-lactamase; Region: Beta-lactamase; pfam00144
395961013979	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961013980	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961013981	Homeodomain-like domain; Region: HTH_23; pfam13384
395961013982	Winged helix-turn helix; Region: HTH_29; pfam13551
395961013983	Homeodomain-like domain; Region: HTH_32; pfam13565
395961013984	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395961013985	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961013986	non-specific DNA binding site [nucleotide binding]; other site
395961013987	sequence-specific DNA binding site [nucleotide binding]; other site
395961013988	salt bridge; other site
395961013989	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
395961013990	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
395961013991	Catalytic site [active]
395961013992	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
395961013993	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
395961013994	substrate binding pocket [chemical binding]; other site
395961013995	chain length determination region; other site
395961013996	substrate-Mg2+ binding site; other site
395961013997	catalytic residues [active]
395961013998	aspartate-rich region 1; other site
395961013999	active site lid residues [active]
395961014000	aspartate-rich region 2; other site
395961014001	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
395961014002	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
395961014003	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395961014004	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961014005	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961014006	Walker A/P-loop; other site
395961014007	ATP binding site [chemical binding]; other site
395961014008	Q-loop/lid; other site
395961014009	ABC transporter signature motif; other site
395961014010	Walker B; other site
395961014011	D-loop; other site
395961014012	H-loop/switch region; other site
395961014013	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
395961014014	active site
395961014015	SAM binding site [chemical binding]; other site
395961014016	homodimer interface [polypeptide binding]; other site
395961014017	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
395961014018	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
395961014019	active site
395961014020	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
395961014021	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
395961014022	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
395961014023	30S subunit binding site; other site
395961014024	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395961014025	DNA-binding site [nucleotide binding]; DNA binding site
395961014026	RNA-binding motif; other site
395961014027	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
395961014028	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
395961014029	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
395961014030	active site residue [active]
395961014031	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
395961014032	active site residue [active]
395961014033	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395961014034	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395961014035	DNA binding residues [nucleotide binding]
395961014036	dimerization interface [polypeptide binding]; other site
395961014037	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
395961014038	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395961014039	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395961014040	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395961014041	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
395961014042	proposed catalytic triad [active]
395961014043	active site nucleophile [active]
395961014044	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
395961014045	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
395961014046	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
395961014047	DNA binding site [nucleotide binding]
395961014048	active site
395961014049	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
395961014050	active site
395961014051	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
395961014052	Fasciclin domain; Region: Fasciclin; pfam02469
395961014053	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
395961014054	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
395961014055	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395961014056	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
395961014057	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395961014058	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
395961014059	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
395961014060	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
395961014061	SmpB-tmRNA interface; other site
395961014062	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
395961014063	Family of unknown function (DUF490); Region: DUF490; pfam04357
395961014064	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
395961014065	Response regulator receiver domain; Region: Response_reg; pfam00072
395961014066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961014067	active site
395961014068	phosphorylation site [posttranslational modification]
395961014069	intermolecular recognition site; other site
395961014070	dimerization interface [polypeptide binding]; other site
395961014071	AAA ATPase domain; Region: AAA_16; pfam13191
395961014072	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961014073	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395961014074	binding surface
395961014075	TPR motif; other site
395961014076	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395961014077	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961014078	binding surface
395961014079	TPR motif; other site
395961014080	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395961014081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961014082	binding surface
395961014083	TPR motif; other site
395961014084	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395961014085	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395961014086	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961014087	binding surface
395961014088	TPR motif; other site
395961014089	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395961014090	Uncharacterized conserved protein [Function unknown]; Region: COG5464
395961014091	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
395961014092	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961014093	Uncharacterized conserved protein [Function unknown]; Region: COG5464
395961014094	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
395961014095	Uncharacterized conserved protein [Function unknown]; Region: COG5464
395961014096	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
395961014097	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961014098	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
395961014099	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
395961014100	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
395961014101	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
395961014102	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
395961014103	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395961014104	active site
395961014105	dimer interface [polypeptide binding]; other site
395961014106	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395961014107	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395961014108	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
395961014109	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
395961014110	Maf-like protein; Region: Maf; pfam02545
395961014111	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
395961014112	active site
395961014113	dimer interface [polypeptide binding]; other site
395961014114	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961014115	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961014116	ligand binding site [chemical binding]; other site
395961014117	flexible hinge region; other site
395961014118	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
395961014119	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
395961014120	dimer interface [polypeptide binding]; other site
395961014121	active site
395961014122	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
395961014123	dimer interface [polypeptide binding]; other site
395961014124	active site
395961014125	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961014126	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961014127	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961014128	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395961014129	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
395961014130	putative NAD(P) binding site [chemical binding]; other site
395961014131	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
395961014132	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
395961014133	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
395961014134	active site
395961014135	substrate binding site [chemical binding]; other site
395961014136	cosubstrate binding site; other site
395961014137	catalytic site [active]
395961014138	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
395961014139	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
395961014140	C-terminal peptidase (prc); Region: prc; TIGR00225
395961014141	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
395961014142	protein binding site [polypeptide binding]; other site
395961014143	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
395961014144	Catalytic dyad [active]
395961014145	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
395961014146	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395961014147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961014148	active site
395961014149	phosphorylation site [posttranslational modification]
395961014150	intermolecular recognition site; other site
395961014151	dimerization interface [polypeptide binding]; other site
395961014152	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395961014153	DNA binding site [nucleotide binding]
395961014154	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
395961014155	ATP-NAD kinase; Region: NAD_kinase; pfam01513
395961014156	Ycf39; Provisional; Region: ycf39; CHL00194
395961014157	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
395961014158	NAD(P) binding site [chemical binding]; other site
395961014159	putative active site [active]
395961014160	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
395961014161	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
395961014162	putative active site pocket [active]
395961014163	4-fold oligomerization interface [polypeptide binding]; other site
395961014164	metal binding residues [ion binding]; metal-binding site
395961014165	3-fold/trimer interface [polypeptide binding]; other site
395961014166	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
395961014167	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
395961014168	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
395961014169	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
395961014170	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
395961014171	NAD(P) binding site [chemical binding]; other site
395961014172	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961014173	putative active site [active]
395961014174	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
395961014175	Peptidase family M23; Region: Peptidase_M23; pfam01551
395961014176	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395961014177	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395961014178	TM-ABC transporter signature motif; other site
395961014179	AAA domain; Region: AAA_17; pfam13207
395961014180	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961014181	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961014182	ligand binding site [chemical binding]; other site
395961014183	flexible hinge region; other site
395961014184	Homeodomain-like domain; Region: HTH_23; pfam13384
395961014185	Winged helix-turn helix; Region: HTH_29; pfam13551
395961014186	Homeodomain-like domain; Region: HTH_32; pfam13565
395961014187	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961014188	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961014189	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
395961014190	Predicted membrane protein [Function unknown]; Region: COG3431
395961014191	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395961014192	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
395961014193	Walker A/P-loop; other site
395961014194	ATP binding site [chemical binding]; other site
395961014195	Q-loop/lid; other site
395961014196	ABC transporter signature motif; other site
395961014197	Walker B; other site
395961014198	D-loop; other site
395961014199	H-loop/switch region; other site
395961014200	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395961014201	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
395961014202	Walker A/P-loop; other site
395961014203	ATP binding site [chemical binding]; other site
395961014204	Q-loop/lid; other site
395961014205	ABC transporter signature motif; other site
395961014206	Walker B; other site
395961014207	D-loop; other site
395961014208	H-loop/switch region; other site
395961014209	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395961014210	NMT1-like family; Region: NMT1_2; pfam13379
395961014211	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395961014212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961014213	dimer interface [polypeptide binding]; other site
395961014214	conserved gate region; other site
395961014215	ABC-ATPase subunit interface; other site
395961014216	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395961014217	NMT1-like family; Region: NMT1_2; pfam13379
395961014218	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
395961014219	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395961014220	ABC-ATPase subunit  interface; other site
395961014221	dimer interface [polypeptide binding]; other site
395961014222	putative PBP binding regions; other site
395961014223	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
395961014224	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
395961014225	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
395961014226	putative active site [active]
395961014227	catalytic site [active]
395961014228	Uncharacterized conserved protein [Function unknown]; Region: COG5464
395961014229	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961014230	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
395961014231	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
395961014232	active site
395961014233	TDP-binding site; other site
395961014234	acceptor substrate-binding pocket; other site
395961014235	homodimer interface [polypeptide binding]; other site
395961014236	Protein of unknown function (DUF433); Region: DUF433; pfam04255
395961014237	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
395961014238	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395961014239	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961014240	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395961014241	Walker A/P-loop; other site
395961014242	ATP binding site [chemical binding]; other site
395961014243	Q-loop/lid; other site
395961014244	ABC transporter signature motif; other site
395961014245	Walker B; other site
395961014246	D-loop; other site
395961014247	H-loop/switch region; other site
395961014248	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
395961014249	amphipathic channel; other site
395961014250	Asn-Pro-Ala signature motifs; other site
395961014251	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961014252	KWG Leptospira; Region: KWG; pfam07656
395961014253	KWG Leptospira; Region: KWG; pfam07656
395961014254	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
395961014255	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
395961014256	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961014257	Walker A motif; other site
395961014258	ATP binding site [chemical binding]; other site
395961014259	Walker B motif; other site
395961014260	arginine finger; other site
395961014261	Peptidase family M41; Region: Peptidase_M41; pfam01434
395961014262	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
395961014263	Chain length determinant protein; Region: Wzz; pfam02706
395961014264	Chain length determinant protein; Region: Wzz; cl15801
395961014265	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961014266	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
395961014267	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
395961014268	Walker A/P-loop; other site
395961014269	ATP binding site [chemical binding]; other site
395961014270	Q-loop/lid; other site
395961014271	ABC transporter signature motif; other site
395961014272	Walker B; other site
395961014273	D-loop; other site
395961014274	H-loop/switch region; other site
395961014275	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
395961014276	putative carbohydrate binding site [chemical binding]; other site
395961014277	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
395961014278	ligand binding site; other site
395961014279	tetramer interface; other site
395961014280	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
395961014281	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
395961014282	NeuB family; Region: NeuB; pfam03102
395961014283	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
395961014284	NeuB binding interface [polypeptide binding]; other site
395961014285	putative substrate binding site [chemical binding]; other site
395961014286	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
395961014287	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
395961014288	Metal-binding active site; metal-binding site
395961014289	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
395961014290	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
395961014291	trimer interface [polypeptide binding]; other site
395961014292	active site
395961014293	substrate binding site [chemical binding]; other site
395961014294	CoA binding site [chemical binding]; other site
395961014295	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
395961014296	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395961014297	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395961014298	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961014299	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961014300	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961014301	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961014302	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
395961014303	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961014304	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961014305	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
395961014306	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961014307	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
395961014308	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
395961014309	active site
395961014310	dimer interface [polypeptide binding]; other site
395961014311	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
395961014312	Ligand Binding Site [chemical binding]; other site
395961014313	Molecular Tunnel; other site
395961014314	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961014315	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
395961014316	putative ADP-binding pocket [chemical binding]; other site
395961014317	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961014318	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961014319	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
395961014320	putative metal binding site; other site
395961014321	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
395961014322	putative glycosyl transferase; Provisional; Region: PRK10307
395961014323	putative acyl transferase; Provisional; Region: PRK10502
395961014324	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
395961014325	putative trimer interface [polypeptide binding]; other site
395961014326	putative active site [active]
395961014327	putative substrate binding site [chemical binding]; other site
395961014328	putative CoA binding site [chemical binding]; other site
395961014329	TPR repeat; Region: TPR_11; pfam13414
395961014330	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961014331	binding surface
395961014332	TPR motif; other site
395961014333	TPR repeat; Region: TPR_11; pfam13414
395961014334	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
395961014335	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
395961014336	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
395961014337	domain interfaces; other site
395961014338	active site
395961014339	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
395961014340	RimM N-terminal domain; Region: RimM; pfam01782
395961014341	PRC-barrel domain; Region: PRC; pfam05239
395961014342	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961014343	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961014344	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961014345	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961014346	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
395961014347	putative active site [active]
395961014348	YdjC motif; other site
395961014349	Mg binding site [ion binding]; other site
395961014350	putative homodimer interface [polypeptide binding]; other site
395961014351	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961014352	GAF domain; Region: GAF; pfam01590
395961014353	PAS domain S-box; Region: sensory_box; TIGR00229
395961014354	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961014355	putative active site [active]
395961014356	heme pocket [chemical binding]; other site
395961014357	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961014358	PAS fold; Region: PAS_3; pfam08447
395961014359	putative active site [active]
395961014360	heme pocket [chemical binding]; other site
395961014361	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395961014362	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961014363	metal binding site [ion binding]; metal-binding site
395961014364	active site
395961014365	I-site; other site
395961014366	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961014367	quinolinate synthetase; Provisional; Region: PRK09375
395961014368	deoxyhypusine synthase-like protein; Provisional; Region: PRK00770
395961014369	deoxyhypusine synthase; Region: dhys; TIGR00321
395961014370	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
395961014371	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395961014372	E3 interaction surface; other site
395961014373	lipoyl attachment site [posttranslational modification]; other site
395961014374	e3 binding domain; Region: E3_binding; pfam02817
395961014375	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
395961014376	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
395961014377	YL1 nuclear protein C-terminal domain; Region: YL1_C; cl02154
395961014378	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
395961014379	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
395961014380	acyl-activating enzyme (AAE) consensus motif; other site
395961014381	putative AMP binding site [chemical binding]; other site
395961014382	putative active site [active]
395961014383	putative CoA binding site [chemical binding]; other site
395961014384	magnesium chelatase subunit H; Provisional; Region: PRK12493
395961014385	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395961014386	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395961014387	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
395961014388	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
395961014389	Walker A/P-loop; other site
395961014390	ATP binding site [chemical binding]; other site
395961014391	TIGR02646 family protein; Region: TIGR02646
395961014392	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
395961014393	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
395961014394	Zn binding site [ion binding]; other site
395961014395	toxin interface [polypeptide binding]; other site
395961014396	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961014397	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961014398	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961014399	putative active site [active]
395961014400	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395961014401	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395961014402	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
395961014403	Protein export membrane protein; Region: SecD_SecF; cl14618
395961014404	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395961014405	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395961014406	HlyD family secretion protein; Region: HlyD_3; pfam13437
395961014407	Phycobilisome protein; Region: Phycobilisome; cl08227
395961014408	Phycobilisome protein; Region: Phycobilisome; cl08227
395961014409	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
395961014410	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
395961014411	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
395961014412	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
395961014413	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
395961014414	CoA binding domain; Region: CoA_binding_2; pfam13380
395961014415	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
395961014416	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
395961014417	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395961014418	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395961014419	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395961014420	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961014421	binding surface
395961014422	TPR motif; other site
395961014423	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395961014424	binding surface
395961014425	TPR motif; other site
395961014426	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
395961014427	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961014428	putative active site [active]
395961014429	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
395961014430	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961014431	ATP binding site [chemical binding]; other site
395961014432	putative Mg++ binding site [ion binding]; other site
395961014433	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961014434	nucleotide binding region [chemical binding]; other site
395961014435	ATP-binding site [chemical binding]; other site
395961014436	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
395961014437	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961014438	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961014439	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961014440	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961014441	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
395961014442	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
395961014443	MoaE interaction surface [polypeptide binding]; other site
395961014444	MoeB interaction surface [polypeptide binding]; other site
395961014445	thiocarboxylated glycine; other site
395961014446	threonine synthase; Validated; Region: PRK07591
395961014447	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
395961014448	homodimer interface [polypeptide binding]; other site
395961014449	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961014450	catalytic residue [active]
395961014451	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
395961014452	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
395961014453	gamma subunit interface [polypeptide binding]; other site
395961014454	epsilon subunit interface [polypeptide binding]; other site
395961014455	LBP interface [polypeptide binding]; other site
395961014456	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
395961014457	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
395961014458	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
395961014459	alpha subunit interaction interface [polypeptide binding]; other site
395961014460	Walker A motif; other site
395961014461	ATP binding site [chemical binding]; other site
395961014462	Walker B motif; other site
395961014463	inhibitor binding site; inhibition site
395961014464	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
395961014465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
395961014466	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961014467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961014468	S-adenosylmethionine binding site [chemical binding]; other site
395961014469	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961014470	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961014471	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961014472	putative active site [active]
395961014473	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
395961014474	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
395961014475	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395961014476	catalytic residue [active]
395961014477	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
395961014478	D1 interface; other site
395961014479	chlorophyll binding site; other site
395961014480	pheophytin binding site; other site
395961014481	beta carotene binding site; other site
395961014482	cytochrome b559 beta interface; other site
395961014483	quinone binding site; other site
395961014484	cytochrome b559 alpha interface; other site
395961014485	protein J interface; other site
395961014486	protein H interface; other site
395961014487	protein X interface; other site
395961014488	core light harvesting protein interface; other site
395961014489	protein L interface; other site
395961014490	CP43 interface; other site
395961014491	protein T interface; other site
395961014492	Fe binding site [ion binding]; other site
395961014493	protein M interface; other site
395961014494	Mn-stabilizing polypeptide interface; other site
395961014495	bromide binding site; other site
395961014496	cytochrome c-550 interface; other site
395961014497	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395961014498	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395961014499	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395961014500	Zn2+ binding site [ion binding]; other site
395961014501	Mg2+ binding site [ion binding]; other site
395961014502	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395961014503	Predicted transcriptional regulator [Transcription]; Region: COG1959
395961014504	Transcriptional regulator; Region: Rrf2; pfam02082
395961014505	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
395961014506	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
395961014507	dimer interface [polypeptide binding]; other site
395961014508	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961014509	catalytic residue [active]
395961014510	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322
395961014511	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395961014512	dimerization interface [polypeptide binding]; other site
395961014513	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395961014514	metal binding site [ion binding]; metal-binding site
395961014515	active site
395961014516	I-site; other site
395961014517	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395961014518	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
395961014519	glycogen synthase; Provisional; Region: glgA; PRK00654
395961014520	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
395961014521	ADP-binding pocket [chemical binding]; other site
395961014522	homodimer interface [polypeptide binding]; other site
395961014523	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
395961014524	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
395961014525	SLBB domain; Region: SLBB; pfam10531
395961014526	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
395961014527	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
395961014528	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
395961014529	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
395961014530	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
395961014531	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395961014532	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395961014533	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
395961014534	active site
395961014535	ribulose/triose binding site [chemical binding]; other site
395961014536	phosphate binding site [ion binding]; other site
395961014537	substrate (anthranilate) binding pocket [chemical binding]; other site
395961014538	product (indole) binding pocket [chemical binding]; other site
395961014539	Stage II sporulation protein; Region: SpoIID; pfam08486
395961014540	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
395961014541	ribonuclease Z; Region: RNase_Z; TIGR02651
395961014542	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
395961014543	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
395961014544	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
395961014545	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
395961014546	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
395961014547	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
395961014548	dimerization interface [polypeptide binding]; other site
395961014549	FAD binding pocket [chemical binding]; other site
395961014550	FAD binding motif [chemical binding]; other site
395961014551	catalytic residues [active]
395961014552	NAD binding pocket [chemical binding]; other site
395961014553	phosphate binding motif [ion binding]; other site
395961014554	beta-alpha-beta structure motif; other site
395961014555	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
395961014556	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
395961014557	Walker A/P-loop; other site
395961014558	ATP binding site [chemical binding]; other site
395961014559	Q-loop/lid; other site
395961014560	ABC transporter signature motif; other site
395961014561	Walker B; other site
395961014562	D-loop; other site
395961014563	H-loop/switch region; other site
395961014564	TOBE-like domain; Region: TOBE_3; pfam12857
395961014565	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
395961014566	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395961014567	putative active site [active]
395961014568	putative metal binding site [ion binding]; other site
395961014569	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
395961014570	Low molecular weight phosphatase family; Region: LMWPc; cd00115
395961014571	active site
395961014572	Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370
395961014573	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
395961014574	Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865
395961014575	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
395961014576	putative active site [active]
395961014577	putative metal binding site [ion binding]; other site
395961014578	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
395961014579	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395961014580	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395961014581	active site
395961014582	metal binding site [ion binding]; metal-binding site
395961014583	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395961014584	active site
395961014585	metal binding site [ion binding]; metal-binding site
395961014586	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
395961014587	Predicted permease [General function prediction only]; Region: COG3329
395961014588	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
395961014589	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395961014590	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
395961014591	Walker A/P-loop; other site
395961014592	ATP binding site [chemical binding]; other site
395961014593	Q-loop/lid; other site
395961014594	ABC transporter signature motif; other site
395961014595	Walker B; other site
395961014596	D-loop; other site
395961014597	H-loop/switch region; other site
395961014598	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
395961014599	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
395961014600	ligand binding site; other site
395961014601	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961014602	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961014603	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961014604	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395961014605	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961014606	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961014607	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
395961014608	protein binding surface [polypeptide binding]; other site
395961014609	HEAT repeats; Region: HEAT_2; pfam13646
395961014610	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
395961014611	protein binding surface [polypeptide binding]; other site
395961014612	HEAT repeats; Region: HEAT_2; pfam13646
395961014613	NACHT domain; Region: NACHT; pfam05729
395961014614	Protein of unknown function (DUF456); Region: DUF456; cl01069
395961014615	PAS fold; Region: PAS_3; pfam08447
395961014616	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395961014617	Histidine kinase; Region: HisKA_2; pfam07568
395961014618	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
395961014619	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395961014620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961014621	S-adenosylmethionine binding site [chemical binding]; other site
395961014622	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961014623	putative active site [active]
395961014624	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395961014625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395961014626	dimer interface [polypeptide binding]; other site
395961014627	conserved gate region; other site
395961014628	ABC-ATPase subunit interface; other site
395961014629	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
395961014630	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
395961014631	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961014632	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
395961014633	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
395961014634	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
395961014635	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961014636	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
395961014637	Transposase [DNA replication, recombination, and repair]; Region: COG5433
395961014638	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
395961014639	NAD(P) binding pocket [chemical binding]; other site
395961014640	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
395961014641	Ycf35; Provisional; Region: ycf35; CHL00193
395961014642	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
395961014643	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
395961014644	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395961014645	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395961014646	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395961014647	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395961014648	ligand binding site [chemical binding]; other site
395961014649	flexible hinge region; other site
395961014650	ribonuclease PH; Reviewed; Region: rph; PRK00173
395961014651	Ribonuclease PH; Region: RNase_PH_bact; cd11362
395961014652	hexamer interface [polypeptide binding]; other site
395961014653	active site
395961014654	cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414
395961014655	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
395961014656	trimer interface [polypeptide binding]; other site
395961014657	active site
395961014658	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395961014659	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395961014660	TM-ABC transporter signature motif; other site
395961014661	Protein of unknown function (DUF721); Region: DUF721; pfam05258
395961014662	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
395961014663	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
395961014664	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395961014665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395961014666	homodimer interface [polypeptide binding]; other site
395961014667	catalytic residue [active]
395961014668	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
395961014669	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
395961014670	histidinol dehydrogenase; Region: hisD; TIGR00069
395961014671	NAD binding site [chemical binding]; other site
395961014672	dimerization interface [polypeptide binding]; other site
395961014673	product binding site; other site
395961014674	substrate binding site [chemical binding]; other site
395961014675	zinc binding site [ion binding]; other site
395961014676	catalytic residues [active]
395961014677	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395961014678	EamA-like transporter family; Region: EamA; pfam00892
395961014679	EamA-like transporter family; Region: EamA; pfam00892
395961014680	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
395961014681	Fatty acid desaturase; Region: FA_desaturase; pfam00487
395961014682	putative di-iron ligands [ion binding]; other site
395961014683	Chromate transporter; Region: Chromate_transp; pfam02417
395961014684	Chromate transporter; Region: Chromate_transp; pfam02417
395961014685	TIR domain; Region: TIR_2; pfam13676
395961014686	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
395961014687	Winged helix-turn helix; Region: HTH_29; pfam13551
395961014688	Homeodomain-like domain; Region: HTH_32; pfam13565
395961014689	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961014690	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961014691	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961014692	S-adenosylmethionine binding site [chemical binding]; other site
395961014693	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961014694	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961014695	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961014696	Uncharacterized conserved protein [Function unknown]; Region: COG5464
395961014697	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961014698	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
395961014699	UbiA prenyltransferase family; Region: UbiA; pfam01040
395961014700	chorismate binding enzyme; Region: Chorismate_bind; cl10555
395961014701	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
395961014702	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
395961014703	active site residue [active]
395961014704	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
395961014705	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
395961014706	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
395961014707	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
395961014708	alpha subunit interface [polypeptide binding]; other site
395961014709	TPP binding site [chemical binding]; other site
395961014710	heterodimer interface [polypeptide binding]; other site
395961014711	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395961014712	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
395961014713	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395961014714	Walker A motif; other site
395961014715	ATP binding site [chemical binding]; other site
395961014716	Family description; Region: UvrD_C_2; pfam13538
395961014717	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
395961014718	protein-export membrane protein SecD; Region: secD; TIGR01129
395961014719	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
395961014720	protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966
395961014721	Protein export membrane protein; Region: SecD_SecF; pfam02355
395961014722	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
395961014723	Peptidase family M50; Region: Peptidase_M50; pfam02163
395961014724	active site
395961014725	putative substrate binding region [chemical binding]; other site
395961014726	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395961014727	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
395961014728	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961014729	S-adenosylmethionine binding site [chemical binding]; other site
395961014730	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
395961014731	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
395961014732	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
395961014733	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
395961014734	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395961014735	catalytic triad [active]
395961014736	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
395961014737	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
395961014738	ring oligomerisation interface [polypeptide binding]; other site
395961014739	ATP/Mg binding site [chemical binding]; other site
395961014740	stacking interactions; other site
395961014741	hinge regions; other site
395961014742	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
395961014743	oligomerisation interface [polypeptide binding]; other site
395961014744	mobile loop; other site
395961014745	roof hairpin; other site
395961014746	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
395961014747	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961014748	putative active site [active]
395961014749	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
395961014750	A new structural DNA glycosylase; Region: AlkD_like; cl11434
395961014751	active site
395961014752	HEAT repeats; Region: HEAT_2; pfam13646
395961014753	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
395961014754	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395961014755	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395961014756	active site
395961014757	catalytic tetrad [active]
395961014758	Protein of unknown function (DUF433); Region: DUF433; cl01030
395961014759	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395961014760	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395961014761	active site
395961014762	metal binding site [ion binding]; metal-binding site
395961014763	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
395961014764	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
395961014765	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395961014766	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395961014767	phycobillisome linker protein; Region: apcE; CHL00091
395961014768	Phycobilisome protein; Region: Phycobilisome; cl08227
395961014769	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
395961014770	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
395961014771	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
395961014772	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
395961014773	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961014774	putative active site [active]
395961014775	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
395961014776	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395961014777	active site
395961014778	motif I; other site
395961014779	motif II; other site
395961014780	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
395961014781	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
395961014782	putative NADP binding site [chemical binding]; other site
395961014783	putative substrate binding site [chemical binding]; other site
395961014784	active site
395961014785	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395961014786	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395961014787	Walker A/P-loop; other site
395961014788	ATP binding site [chemical binding]; other site
395961014789	Q-loop/lid; other site
395961014790	ABC transporter signature motif; other site
395961014791	Walker B; other site
395961014792	D-loop; other site
395961014793	H-loop/switch region; other site
395961014794	DevC protein; Region: devC; TIGR01185
395961014795	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395961014796	FtsX-like permease family; Region: FtsX; pfam02687
395961014797	Dynamin family; Region: Dynamin_N; pfam00350
395961014798	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
395961014799	G1 box; other site
395961014800	GTP/Mg2+ binding site [chemical binding]; other site
395961014801	Switch I region; other site
395961014802	G2 box; other site
395961014803	Switch II region; other site
395961014804	G3 box; other site
395961014805	G4 box; other site
395961014806	G5 box; other site
395961014807	Domain of unknown function (DUF697); Region: DUF697; pfam05128
395961014808	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
395961014809	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
395961014810	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
395961014811	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
395961014812	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
395961014813	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
395961014814	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
395961014815	peptide chain release factor 2; Validated; Region: prfB; PRK00578
395961014816	PCRF domain; Region: PCRF; pfam03462
395961014817	RF-1 domain; Region: RF-1; pfam00472
395961014818	Thf1-like protein; Reviewed; Region: PRK13266
395961014819	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
395961014820	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
395961014821	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395961014822	phosphopeptide binding site; other site
395961014823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961014824	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961014825	phosphorylation site [posttranslational modification]
395961014826	intermolecular recognition site; other site
395961014827	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
395961014828	nickel binding site [ion binding]; other site
395961014829	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
395961014830	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
395961014831	NAD binding site [chemical binding]; other site
395961014832	ATP-grasp domain; Region: ATP-grasp; pfam02222
395961014833	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
395961014834	Peptidase family M48; Region: Peptidase_M48; cl12018
395961014835	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961014836	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961014837	active site
395961014838	Chain length determinant protein; Region: Wzz; pfam02706
395961014839	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
395961014840	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
395961014841	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
395961014842	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
395961014843	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395961014844	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961014845	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961014846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961014847	S-adenosylmethionine binding site [chemical binding]; other site
395961014848	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
395961014849	Winged helix-turn helix; Region: HTH_29; pfam13551
395961014850	Homeodomain-like domain; Region: HTH_32; pfam13565
395961014851	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961014852	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961014853	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395961014854	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
395961014855	putative ADP-binding pocket [chemical binding]; other site
395961014856	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
395961014857	colanic acid exporter; Provisional; Region: PRK10459
395961014858	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
395961014859	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
395961014860	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395961014861	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395961014862	active site
395961014863	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
395961014864	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
395961014865	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
395961014866	substrate binding site; other site
395961014867	Predicted dehydrogenase [General function prediction only]; Region: COG0579
395961014868	hydroxyglutarate oxidase; Provisional; Region: PRK11728
395961014869	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
395961014870	extended (e) SDRs; Region: SDR_e; cd08946
395961014871	NAD(P) binding site [chemical binding]; other site
395961014872	active site
395961014873	substrate binding site [chemical binding]; other site
395961014874	Protein of unknown function (DUF563); Region: DUF563; pfam04577
395961014875	Protein of unknown function (DUF563); Region: DUF563; pfam04577
395961014876	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
395961014877	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
395961014878	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395961014879	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
395961014880	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
395961014881	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
395961014882	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395961014883	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
395961014884	active site
395961014885	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395961014886	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
395961014887	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961014888	S-adenosylmethionine binding site [chemical binding]; other site
395961014889	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
395961014890	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
395961014891	trimer interface [polypeptide binding]; other site
395961014892	active site
395961014893	substrate binding site [chemical binding]; other site
395961014894	CoA binding site [chemical binding]; other site
395961014895	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
395961014896	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395961014897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961014898	S-adenosylmethionine binding site [chemical binding]; other site
395961014899	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
395961014900	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
395961014901	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395961014902	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
395961014903	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395961014904	active site
395961014905	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395961014906	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395961014907	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
395961014908	Ligand Binding Site [chemical binding]; other site
395961014909	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
395961014910	active site
395961014911	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
395961014912	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395961014913	FeS/SAM binding site; other site
395961014914	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
395961014915	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
395961014916	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
395961014917	active site
395961014918	HIGH motif; other site
395961014919	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
395961014920	KMSKS motif; other site
395961014921	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
395961014922	tRNA binding surface [nucleotide binding]; other site
395961014923	anticodon binding site; other site
395961014924	Uncharacterized conserved protein [Function unknown]; Region: COG4278
395961014925	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060
395961014926	Fatty acid desaturase; Region: FA_desaturase; pfam00487
395961014927	putative di-iron ligands [ion binding]; other site
395961014928	H+ Antiporter protein; Region: 2A0121; TIGR00900
395961014929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961014930	putative substrate translocation pore; other site
395961014931	excinuclease ABC subunit B; Provisional; Region: PRK05298
395961014932	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395961014933	ATP binding site [chemical binding]; other site
395961014934	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395961014935	nucleotide binding region [chemical binding]; other site
395961014936	ATP-binding site [chemical binding]; other site
395961014937	Ultra-violet resistance protein B; Region: UvrB; pfam12344
395961014938	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
395961014939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961014940	DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958
395961014941	active site
395961014942	phosphorylation site [posttranslational modification]
395961014943	intermolecular recognition site; other site
395961014944	dimerization interface [polypeptide binding]; other site
395961014945	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395961014946	DNA binding residues [nucleotide binding]
395961014947	dimerization interface [polypeptide binding]; other site
395961014948	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
395961014949	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395961014950	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
395961014951	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
395961014952	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395961014953	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
395961014954	classical (c) SDRs; Region: SDR_c; cd05233
395961014955	NAD(P) binding site [chemical binding]; other site
395961014956	active site
395961014957	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
395961014958	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
395961014959	dimer interface [polypeptide binding]; other site
395961014960	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
395961014961	active site
395961014962	Fe binding site [ion binding]; other site
395961014963	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395961014964	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
395961014965	active site
395961014966	oxyanion hole [active]
395961014967	catalytic triad [active]
395961014968	Integral membrane protein DUF92; Region: DUF92; pfam01940
395961014969	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
395961014970	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
395961014971	Fasciclin domain; Region: Fasciclin; pfam02469
395961014972	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
395961014973	nudix motif; other site
395961014974	Fasciclin domain; Region: Fasciclin; pfam02469
395961014975	Predicted methyltransferases [General function prediction only]; Region: COG0313
395961014976	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
395961014977	putative SAM binding site [chemical binding]; other site
395961014978	putative homodimer interface [polypeptide binding]; other site
395961014979	Beta-carotene ketolase/oxygenase (CrtW, also known as CrtO), the carotenoid astaxanthin biosynthetic enzyme, initially catalyzes the addition of two keto groups to carbons C4 and C4' of beta-carotene. Carotenoids are important natural pigments...; Region: CrtW_beta-carotene-ketolase; cd03513
395961014980	Fatty acid desaturase; Region: FA_desaturase; pfam00487
395961014981	putative di-iron ligands [ion binding]; other site
395961014982	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
395961014983	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961014984	non-specific DNA binding site [nucleotide binding]; other site
395961014985	salt bridge; other site
395961014986	sequence-specific DNA binding site [nucleotide binding]; other site
395961014987	TonB C terminal; Region: TonB_2; pfam13103
395961014988	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
395961014989	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
395961014990	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
395961014991	Walker A/P-loop; other site
395961014992	ATP binding site [chemical binding]; other site
395961014993	Q-loop/lid; other site
395961014994	ABC transporter signature motif; other site
395961014995	Walker B; other site
395961014996	D-loop; other site
395961014997	H-loop/switch region; other site
395961014998	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
395961014999	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
395961015000	Walker A/P-loop; other site
395961015001	ATP binding site [chemical binding]; other site
395961015002	Q-loop/lid; other site
395961015003	ABC transporter signature motif; other site
395961015004	Walker B; other site
395961015005	D-loop; other site
395961015006	H-loop/switch region; other site
395961015007	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
395961015008	hypothetical protein; Reviewed; Region: PRK12497
395961015009	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
395961015010	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
395961015011	active site
395961015012	zinc binding site [ion binding]; other site
395961015013	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
395961015014	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395961015015	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395961015016	catalytic residue [active]
395961015017	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
395961015018	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
395961015019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395961015020	S-adenosylmethionine binding site [chemical binding]; other site
395961015021	homoserine kinase; Provisional; Region: PRK01212
395961015022	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
395961015023	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
395961015024	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
395961015025	MG2 domain; Region: A2M_N; pfam01835
395961015026	Hemerythrin; Region: Hemerythrin; cd12107
395961015027	Fe binding site [ion binding]; other site
395961015028	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
395961015029	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
395961015030	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
395961015031	G1 box; other site
395961015032	GTP/Mg2+ binding site [chemical binding]; other site
395961015033	G2 box; other site
395961015034	Switch I region; other site
395961015035	G3 box; other site
395961015036	Switch II region; other site
395961015037	G4 box; other site
395961015038	G5 box; other site
395961015039	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
395961015040	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
395961015041	heme-binding site [chemical binding]; other site
395961015042	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
395961015043	heterotetramer interface [polypeptide binding]; other site
395961015044	active site pocket [active]
395961015045	cleavage site
395961015046	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961015047	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961015048	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961015049	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961015050	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961015051	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395961015052	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961015053	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961015054	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961015055	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961015056	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395961015057	Protein of unknown function DUF72; Region: DUF72; pfam01904
395961015058	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
395961015059	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
395961015060	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
395961015061	Winged helix-turn helix; Region: HTH_29; pfam13551
395961015062	Homeodomain-like domain; Region: HTH_32; pfam13565
395961015063	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395961015064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395961015065	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
395961015066	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
395961015067	transmembrane helices; other site
395961015068	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
395961015069	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
395961015070	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
395961015071	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
395961015072	G-X-X-G motif; other site
395961015073	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
395961015074	RxxxH motif; other site
395961015075	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
395961015076	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
395961015077	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
395961015078	Bacterial PH domain; Region: DUF304; pfam03703
395961015079	ribonuclease P; Reviewed; Region: rnpA; PRK03031
395961015080	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
395961015081	acyl-CoA synthetase; Validated; Region: PRK07788
395961015082	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
395961015083	acyl-activating enzyme (AAE) consensus motif; other site
395961015084	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
395961015085	AMP binding site [chemical binding]; other site
395961015086	active site
395961015087	acyl-activating enzyme (AAE) consensus motif; other site
395961015088	CoA binding site [chemical binding]; other site
395961015089	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395961015090	classical (c) SDRs; Region: SDR_c; cd05233
395961015091	NAD(P) binding site [chemical binding]; other site
395961015092	active site
395961015093	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
395961015094	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395961015095	structural tetrad; other site
395961015096	Transposase, Mutator family; Region: Transposase_mut; pfam00872
395961015097	MULE transposase domain; Region: MULE; pfam10551
395961015098	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
395961015099	short chain dehydrogenase; Validated; Region: PRK06182
395961015100	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395961015101	NADP binding site [chemical binding]; other site
395961015102	active site
395961015103	steroid binding site; other site
395961015104	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395961015105	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961015106	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
395961015107	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
395961015108	homodimer interface [polypeptide binding]; other site
395961015109	active site
395961015110	TDP-binding site; other site
395961015111	acceptor substrate-binding pocket; other site
395961015112	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395961015113	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961015114	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961015115	Protein of unknown function, DUF606; Region: DUF606; pfam04657
395961015116	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395961015117	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395961015118	putative substrate translocation pore; other site
395961015119	short chain dehydrogenase; Validated; Region: PRK08264
395961015120	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961015121	NAD(P) binding site [chemical binding]; other site
395961015122	active site
395961015123	Predicted transcriptional regulators [Transcription]; Region: COG1733
395961015124	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395961015125	dimerization interface [polypeptide binding]; other site
395961015126	putative DNA binding site [nucleotide binding]; other site
395961015127	putative Zn2+ binding site [ion binding]; other site
395961015128	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
395961015129	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395961015130	P-loop; other site
395961015131	Magnesium ion binding site [ion binding]; other site
395961015132	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395961015133	Magnesium ion binding site [ion binding]; other site
395961015134	ChaB; Region: ChaB; pfam06150
395961015135	PIN domain; Region: PIN_3; pfam13470
395961015136	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
395961015137	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
395961015138	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
395961015139	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
395961015140	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
395961015141	AAA ATPase domain; Region: AAA_16; pfam13191
395961015142	NACHT domain; Region: NACHT; pfam05729
395961015143	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395961015144	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961015145	structural tetrad; other site
395961015146	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
395961015147	structural tetrad; other site
395961015148	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
395961015149	Transposase; Region: DDE_Tnp_ISL3; pfam01610
395961015150	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
395961015151	Transposase; Region: DDE_Tnp_ISL3; pfam01610
395961015152	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
395961015153	Transposase, Mutator family; Region: Transposase_mut; pfam00872
395961015154	MULE transposase domain; Region: MULE; pfam10551
395961015155	transposase; Validated; Region: PRK08181
395961015156	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961015157	Walker A motif; other site
395961015158	ATP binding site [chemical binding]; other site
395961015159	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
395961015160	active site
395961015161	metal binding site [ion binding]; metal-binding site
395961015162	interdomain interaction site; other site
395961015163	ParB-like nuclease domain; Region: ParBc; cl02129
395961015164	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961015165	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961015166	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395961015167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961015168	active site
395961015169	phosphorylation site [posttranslational modification]
395961015170	intermolecular recognition site; other site
395961015171	dimerization interface [polypeptide binding]; other site
395961015172	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395961015173	active site
395961015174	dimerization interface [polypeptide binding]; other site
395961015175	chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029
395961015176	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395961015177	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395961015178	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
395961015179	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
395961015180	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
395961015181	homodimer interface [polypeptide binding]; other site
395961015182	active site
395961015183	TDP-binding site; other site
395961015184	acceptor substrate-binding pocket; other site
395961015185	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
395961015186	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395961015187	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395961015188	NAD(P) binding site [chemical binding]; other site
395961015189	active site
395961015190	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
395961015191	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
395961015192	Flavin binding site [chemical binding]; other site
395961015193	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
395961015194	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
395961015195	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961015196	dimer interface [polypeptide binding]; other site
395961015197	phosphorylation site [posttranslational modification]
395961015198	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961015199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961015200	ATP binding site [chemical binding]; other site
395961015201	G-X-G motif; other site
395961015202	Response regulator receiver domain; Region: Response_reg; pfam00072
395961015203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961015204	active site
395961015205	phosphorylation site [posttranslational modification]
395961015206	intermolecular recognition site; other site
395961015207	dimerization interface [polypeptide binding]; other site
395961015208	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395961015209	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395961015210	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395961015211	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395961015212	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
395961015213	N-terminal domain interface [polypeptide binding]; other site
395961015214	dimer interface [polypeptide binding]; other site
395961015215	substrate binding pocket (H-site) [chemical binding]; other site
395961015216	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
395961015217	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395961015218	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961015219	dimer interface [polypeptide binding]; other site
395961015220	phosphorylation site [posttranslational modification]
395961015221	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961015222	ATP binding site [chemical binding]; other site
395961015223	Mg2+ binding site [ion binding]; other site
395961015224	G-X-G motif; other site
395961015225	Response regulator receiver domain; Region: Response_reg; pfam00072
395961015226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961015227	active site
395961015228	phosphorylation site [posttranslational modification]
395961015229	intermolecular recognition site; other site
395961015230	dimerization interface [polypeptide binding]; other site
395961015231	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
395961015232	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
395961015233	P loop; other site
395961015234	Nucleotide binding site [chemical binding]; other site
395961015235	DTAP/Switch II; other site
395961015236	Switch I; other site
395961015237	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
395961015238	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
395961015239	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395961015240	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
395961015241	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
395961015242	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
395961015243	ATP-grasp domain; Region: ATP-grasp; pfam02222
395961015244	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
395961015245	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961015246	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
395961015247	Transposase [DNA replication, recombination, and repair]; Region: COG5433
395961015248	transposase; Validated; Region: PRK08181
395961015249	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395961015250	Walker A motif; other site
395961015251	ATP binding site [chemical binding]; other site
395961015252	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
395961015253	Transposase; Region: DDE_Tnp_ISL3; pfam01610
395961015254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
395961015255	Transposase; Region: DDE_Tnp_ISL3; pfam01610
395961015256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
395961015257	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
395961015258	Cupin domain; Region: Cupin_2; pfam07883
395961015259	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
395961015260	Coenzyme A binding pocket [chemical binding]; other site
395961015261	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
395961015262	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
395961015263	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961015264	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961015265	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
395961015266	Helix-turn-helix domain; Region: HTH_18; pfam12833
395961015267	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
395961015268	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395961015269	catalytic loop [active]
395961015270	iron binding site [ion binding]; other site
395961015271	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
395961015272	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
395961015273	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
395961015274	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
395961015275	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
395961015276	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395961015277	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
395961015278	XdhC Rossmann domain; Region: XdhC_C; pfam13478
395961015279	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
395961015280	Ligand binding site; other site
395961015281	metal-binding site
395961015282	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961015283	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961015284	short chain dehydrogenase; Provisional; Region: PRK06172
395961015285	classical (c) SDRs; Region: SDR_c; cd05233
395961015286	NAD(P) binding site [chemical binding]; other site
395961015287	active site
395961015288	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
395961015289	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
395961015290	folate binding site [chemical binding]; other site
395961015291	NADP+ binding site [chemical binding]; other site
395961015292	RibD C-terminal domain; Region: RibD_C; cl17279
395961015293	Cupin domain; Region: Cupin_2; cl17218
395961015294	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
395961015295	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
395961015296	ParB-like nuclease domain; Region: ParB; smart00470
395961015297	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
395961015298	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
395961015299	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395961015300	P-loop; other site
395961015301	Magnesium ion binding site [ion binding]; other site
395961015302	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395961015303	Magnesium ion binding site [ion binding]; other site
395961015304	Transposase, Mutator family; Region: Transposase_mut; pfam00872
395961015305	MULE transposase domain; Region: MULE; pfam10551
395961015306	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
395961015307	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
395961015308	putative active site [active]
395961015309	TSCPD domain; Region: TSCPD; cl14834
395961015310	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395961015311	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
395961015312	TAP-like protein; Region: Abhydrolase_4; pfam08386
395961015313	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395961015314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961015315	active site
395961015316	phosphorylation site [posttranslational modification]
395961015317	intermolecular recognition site; other site
395961015318	dimerization interface [polypeptide binding]; other site
395961015319	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395961015320	DNA binding site [nucleotide binding]
395961015321	Cache domain; Region: Cache_1; pfam02743
395961015322	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961015323	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961015324	HAMP domain; Region: HAMP; pfam00672
395961015325	dimerization interface [polypeptide binding]; other site
395961015326	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395961015327	PAS fold; Region: PAS_3; pfam08447
395961015328	putative active site [active]
395961015329	heme pocket [chemical binding]; other site
395961015330	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395961015331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395961015332	dimer interface [polypeptide binding]; other site
395961015333	phosphorylation site [posttranslational modification]
395961015334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395961015335	ATP binding site [chemical binding]; other site
395961015336	Mg2+ binding site [ion binding]; other site
395961015337	G-X-G motif; other site
395961015338	Response regulator receiver domain; Region: Response_reg; pfam00072
395961015339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395961015340	active site
395961015341	phosphorylation site [posttranslational modification]
395961015342	intermolecular recognition site; other site
395961015343	dimerization interface [polypeptide binding]; other site
395961015344	Transposase, Mutator family; Region: Transposase_mut; pfam00872
395961015345	MULE transposase domain; Region: MULE; pfam10551
395961015346	PIN domain; Region: PIN_3; pfam13470
395961015347	Verru_Chthon cassette protein A; Region: Verru_Chthon_A; TIGR02600
395961015348	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395961015349	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395961015350	non-specific DNA binding site [nucleotide binding]; other site
395961015351	salt bridge; other site
395961015352	sequence-specific DNA binding site [nucleotide binding]; other site
395961015353	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
395961015354	Dynamin family; Region: Dynamin_N; pfam00350
395961015355	G1 box; other site
395961015356	GTP/Mg2+ binding site [chemical binding]; other site
395961015357	G2 box; other site
395961015358	Switch I region; other site
395961015359	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
395961015360	putative homodimer interface [polypeptide binding]; other site
395961015361	putative active site [active]
395961015362	catalytic site [active]
395961015363	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961015364	ATP-dependent helicase HepA; Validated; Region: PRK04914
395961015365	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395961015366	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395961015367	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
395961015368	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
395961015369	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395961015370	putative active site [active]
395961015371	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
395961015372	oligomeric interface; other site
395961015373	putative active site [active]
395961015374	homodimer interface [polypeptide binding]; other site
395961015375	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
395961015376	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
395961015377	CRISPR-associated protein, TIGR03985 family; Region: TIGR03985
395961015378	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
395961015379	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
395961015380	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
395961015381	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395961015382	Zn2+ binding site [ion binding]; other site
395961015383	Mg2+ binding site [ion binding]; other site
395961015384	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
395961015385	putative ADP-ribose binding site [chemical binding]; other site
395961015386	putative active site [active]
395961015387	Uncharacterized conserved protein [Function unknown]; Region: COG1432
395961015388	LabA_like proteins; Region: LabA; cd10911
395961015389	putative metal binding site [ion binding]; other site
395961015390	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
395961015391	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
395961015392	metal ion-dependent adhesion site (MIDAS); other site
395961015393	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
395961015394	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
395961015395	DNA binding residues [nucleotide binding]
395961015396	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
395961015397	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
395961015398	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395961015399	active site
395961015400	NTP binding site [chemical binding]; other site
395961015401	metal binding triad [ion binding]; metal-binding site
395961015402	antibiotic binding site [chemical binding]; other site
395961015403	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
395961015404	putative active site [active]
395961015405	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
395961015406	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395961015407	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
395961015408	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
395961015409	Transposase, Mutator family; Region: Transposase_mut; pfam00872
395961015410	MULE transposase domain; Region: MULE; pfam10551
395961015411	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395961015412	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
395961015413	conserved cys residue [active]
395961015414	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395961015415	OsmC-like protein; Region: OsmC; pfam02566
395961015416	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395961015417	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395961015418	active site
395961015419	metal binding site [ion binding]; metal-binding site
395961015420	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
395961015421	putative hydrophobic ligand binding site [chemical binding]; other site
395961015422	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105