-- dump date   	20140619_054824
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
497965000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
497965000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
497965000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965000004	Walker A motif; other site
497965000005	ATP binding site [chemical binding]; other site
497965000006	Walker B motif; other site
497965000007	arginine finger; other site
497965000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
497965000009	DnaA box-binding interface [nucleotide binding]; other site
497965000010	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
497965000011	UbiA prenyltransferase family; Region: UbiA; pfam01040
497965000012	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
497965000013	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965000014	non-specific DNA binding site [nucleotide binding]; other site
497965000015	salt bridge; other site
497965000016	sequence-specific DNA binding site [nucleotide binding]; other site
497965000017	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
497965000018	Sulfate transporter family; Region: Sulfate_transp; pfam00916
497965000019	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
497965000020	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
497965000021	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965000022	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965000023	ligand binding site [chemical binding]; other site
497965000024	flexible hinge region; other site
497965000025	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497965000026	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965000027	S-adenosylmethionine binding site [chemical binding]; other site
497965000028	Peptidase family M48; Region: Peptidase_M48; pfam01435
497965000029	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
497965000030	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
497965000031	active site
497965000032	homodimer interface [polypeptide binding]; other site
497965000033	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
497965000034	classical (c) SDRs; Region: SDR_c; cd05233
497965000035	NAD(P) binding site [chemical binding]; other site
497965000036	active site
497965000037	DNA repair protein RadA; Provisional; Region: PRK11823
497965000038	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
497965000039	Walker A motif/ATP binding site; other site
497965000040	ATP binding site [chemical binding]; other site
497965000041	Walker B motif; other site
497965000042	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
497965000043	Ycf27; Reviewed; Region: orf27; CHL00148
497965000044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965000045	active site
497965000046	phosphorylation site [posttranslational modification]
497965000047	intermolecular recognition site; other site
497965000048	dimerization interface [polypeptide binding]; other site
497965000049	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965000050	DNA binding site [nucleotide binding]
497965000051	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
497965000052	GAF domain; Region: GAF_2; pfam13185
497965000053	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
497965000054	putative active site pocket [active]
497965000055	dimerization interface [polypeptide binding]; other site
497965000056	putative catalytic residue [active]
497965000057	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965000058	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965000059	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965000060	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965000061	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965000062	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965000063	dimer interface [polypeptide binding]; other site
497965000064	phosphorylation site [posttranslational modification]
497965000065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965000066	ATP binding site [chemical binding]; other site
497965000067	Mg2+ binding site [ion binding]; other site
497965000068	G-X-G motif; other site
497965000069	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
497965000070	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965000071	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965000072	putative active site [active]
497965000073	heme pocket [chemical binding]; other site
497965000074	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965000075	putative active site [active]
497965000076	heme pocket [chemical binding]; other site
497965000077	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965000078	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965000079	metal binding site [ion binding]; metal-binding site
497965000080	active site
497965000081	I-site; other site
497965000082	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965000083	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
497965000084	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965000085	Coenzyme A binding pocket [chemical binding]; other site
497965000086	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
497965000087	tetramer (dimer of dimers) interface [polypeptide binding]; other site
497965000088	active site
497965000089	dimer interface [polypeptide binding]; other site
497965000090	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
497965000091	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
497965000092	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
497965000093	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
497965000094	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
497965000095	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
497965000096	putative active site [active]
497965000097	putative NTP binding site [chemical binding]; other site
497965000098	putative nucleic acid binding site [nucleotide binding]; other site
497965000099	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
497965000100	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497965000101	Ligand Binding Site [chemical binding]; other site
497965000102	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
497965000103	Ligand Binding Site [chemical binding]; other site
497965000104	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965000105	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965000106	active site
497965000107	ATP binding site [chemical binding]; other site
497965000108	substrate binding site [chemical binding]; other site
497965000109	activation loop (A-loop); other site
497965000110	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
497965000111	Putative transcription activator [Transcription]; Region: TenA; COG0819
497965000112	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965000113	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000114	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000115	TPR repeat; Region: TPR_11; pfam13414
497965000116	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965000117	binding surface
497965000118	TPR motif; other site
497965000119	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
497965000120	SNF2 Helicase protein; Region: DUF3670; pfam12419
497965000121	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965000122	ATP binding site [chemical binding]; other site
497965000123	putative Mg++ binding site [ion binding]; other site
497965000124	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965000125	nucleotide binding region [chemical binding]; other site
497965000126	ATP-binding site [chemical binding]; other site
497965000127	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
497965000128	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
497965000129	PYR/PP interface [polypeptide binding]; other site
497965000130	dimer interface [polypeptide binding]; other site
497965000131	TPP binding site [chemical binding]; other site
497965000132	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
497965000133	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
497965000134	TPP-binding site [chemical binding]; other site
497965000135	dimer interface [polypeptide binding]; other site
497965000136	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
497965000137	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
497965000138	CAAX protease self-immunity; Region: Abi; pfam02517
497965000139	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
497965000140	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965000141	Walker A motif; other site
497965000142	ATP binding site [chemical binding]; other site
497965000143	Walker B motif; other site
497965000144	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965000145	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965000146	active site
497965000147	ATP binding site [chemical binding]; other site
497965000148	substrate binding site [chemical binding]; other site
497965000149	activation loop (A-loop); other site
497965000150	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
497965000151	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
497965000152	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
497965000153	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
497965000154	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
497965000155	Secretin and TonB N terminus short domain; Region: STN; pfam07660
497965000156	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
497965000157	radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261
497965000158	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965000159	FeS/SAM binding site; other site
497965000160	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
497965000161	rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260
497965000162	rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260
497965000163	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
497965000164	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497965000165	substrate binding pocket [chemical binding]; other site
497965000166	membrane-bound complex binding site; other site
497965000167	hinge residues; other site
497965000168	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
497965000169	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
497965000170	P loop; other site
497965000171	Nucleotide binding site [chemical binding]; other site
497965000172	DTAP/Switch II; other site
497965000173	Switch I; other site
497965000174	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
497965000175	Lysozyme family protein [General function prediction only]; Region: COG5526
497965000176	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
497965000177	phosphodiesterase YaeI; Provisional; Region: PRK11340
497965000178	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
497965000179	putative active site [active]
497965000180	putative metal binding site [ion binding]; other site
497965000181	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
497965000182	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
497965000183	putative NADP binding site [chemical binding]; other site
497965000184	putative substrate binding site [chemical binding]; other site
497965000185	active site
497965000186	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
497965000187	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
497965000188	active site
497965000189	catalytic tetrad [active]
497965000190	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
497965000191	catalytic tetrad [active]
497965000192	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
497965000193	Zn2+ binding site [ion binding]; other site
497965000194	Mg2+ binding site [ion binding]; other site
497965000195	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
497965000196	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
497965000197	L-asparaginase II; Region: Asparaginase_II; cl01842
497965000198	Bacterial SH3 domain; Region: SH3_3; cl17532
497965000199	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
497965000200	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
497965000201	[2Fe-2S] cluster binding site [ion binding]; other site
497965000202	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
497965000203	hydrophobic ligand binding site; other site
497965000204	Exoribonuclease R [Transcription]; Region: VacB; COG0557
497965000205	RNB domain; Region: RNB; pfam00773
497965000206	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
497965000207	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
497965000208	substrate binding pocket [chemical binding]; other site
497965000209	chain length determination region; other site
497965000210	substrate-Mg2+ binding site; other site
497965000211	catalytic residues [active]
497965000212	aspartate-rich region 1; other site
497965000213	active site lid residues [active]
497965000214	aspartate-rich region 2; other site
497965000215	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965000216	NAD(P) binding site [chemical binding]; other site
497965000217	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965000218	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
497965000219	active site
497965000220	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
497965000221	Leucine-rich repeats; other site
497965000222	Substrate binding site [chemical binding]; other site
497965000223	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
497965000224	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
497965000225	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
497965000226	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
497965000227	AAA ATPase domain; Region: AAA_15; pfam13175
497965000228	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965000229	Q-loop/lid; other site
497965000230	ABC transporter signature motif; other site
497965000231	Walker B; other site
497965000232	D-loop; other site
497965000233	H-loop/switch region; other site
497965000234	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
497965000235	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
497965000236	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
497965000237	active site
497965000238	dimer interface [polypeptide binding]; other site
497965000239	motif 1; other site
497965000240	motif 2; other site
497965000241	motif 3; other site
497965000242	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
497965000243	anticodon binding site; other site
497965000244	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
497965000245	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497965000246	active site
497965000247	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
497965000248	DNA protecting protein DprA; Region: dprA; TIGR00732
497965000249	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
497965000250	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
497965000251	putative active site [active]
497965000252	oxyanion strand; other site
497965000253	catalytic triad [active]
497965000254	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965000255	putative active site [active]
497965000256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
497965000257	Predicted kinase [General function prediction only]; Region: COG0645
497965000258	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
497965000259	ATP-binding site [chemical binding]; other site
497965000260	Gluconate-6-phosphate binding site [chemical binding]; other site
497965000261	FtsH Extracellular; Region: FtsH_ext; pfam06480
497965000262	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
497965000263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965000264	Walker A motif; other site
497965000265	ATP binding site [chemical binding]; other site
497965000266	Walker B motif; other site
497965000267	arginine finger; other site
497965000268	Peptidase family M41; Region: Peptidase_M41; pfam01434
497965000269	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965000270	NACHT domain; Region: NACHT; pfam05729
497965000271	Walker A motif; other site
497965000272	ATP binding site [chemical binding]; other site
497965000273	Walker B motif; other site
497965000274	HEAT repeats; Region: HEAT_2; pfam13646
497965000275	HEAT repeats; Region: HEAT_2; pfam13646
497965000276	HEAT repeats; Region: HEAT_2; pfam13646
497965000277	HEAT repeats; Region: HEAT_2; pfam13646
497965000278	HEAT repeats; Region: HEAT_2; pfam13646
497965000279	HEAT repeats; Region: HEAT_2; pfam13646
497965000280	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
497965000281	BON domain; Region: BON; pfam04972
497965000282	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
497965000283	substrate binding pocket [chemical binding]; other site
497965000284	substrate-Mg2+ binding site; other site
497965000285	aspartate-rich region 1; other site
497965000286	aspartate-rich region 2; other site
497965000287	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
497965000288	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
497965000289	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
497965000290	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497965000291	catalytic loop [active]
497965000292	iron binding site [ion binding]; other site
497965000293	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
497965000294	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497965000295	catalytic loop [active]
497965000296	iron binding site [ion binding]; other site
497965000297	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
497965000298	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
497965000299	manganese transport protein MntH; Reviewed; Region: PRK00701
497965000300	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
497965000301	hypothetical protein; Provisional; Region: PRK02237
497965000302	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
497965000303	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497965000304	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
497965000305	Exoribonuclease R [Transcription]; Region: VacB; COG0557
497965000306	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
497965000307	RNB domain; Region: RNB; pfam00773
497965000308	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
497965000309	RNA binding site [nucleotide binding]; other site
497965000310	Clp protease; Region: CLP_protease; pfam00574
497965000311	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
497965000312	oligomer interface [polypeptide binding]; other site
497965000313	active site residues [active]
497965000314	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
497965000315	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
497965000316	catalytic site [active]
497965000317	G-X2-G-X-G-K; other site
497965000318	hypothetical protein; Provisional; Region: PRK04323
497965000319	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
497965000320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965000321	S-adenosylmethionine binding site [chemical binding]; other site
497965000322	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
497965000323	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
497965000324	homodimer interface [polypeptide binding]; other site
497965000325	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965000326	catalytic residue [active]
497965000327	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
497965000328	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965000329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965000330	active site
497965000331	phosphorylation site [posttranslational modification]
497965000332	intermolecular recognition site; other site
497965000333	dimerization interface [polypeptide binding]; other site
497965000334	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965000335	DNA binding site [nucleotide binding]
497965000336	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
497965000337	phosphatidate cytidylyltransferase; Region: PLN02953
497965000338	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
497965000339	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
497965000340	putative active site [active]
497965000341	catalytic triad [active]
497965000342	putative dimer interface [polypeptide binding]; other site
497965000343	Putative serine esterase (DUF676); Region: DUF676; pfam05057
497965000344	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965000345	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
497965000346	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
497965000347	active site
497965000348	interdomain interaction site; other site
497965000349	putative metal-binding site [ion binding]; other site
497965000350	nucleotide binding site [chemical binding]; other site
497965000351	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
497965000352	domain I; other site
497965000353	phosphate binding site [ion binding]; other site
497965000354	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
497965000355	domain II; other site
497965000356	domain III; other site
497965000357	nucleotide binding site [chemical binding]; other site
497965000358	DNA binding groove [nucleotide binding]
497965000359	catalytic site [active]
497965000360	domain IV; other site
497965000361	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
497965000362	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
497965000363	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
497965000364	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
497965000365	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
497965000366	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497965000367	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
497965000368	RES domain; Region: RES; pfam08808
497965000369	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
497965000370	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965000371	putative active site [active]
497965000372	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
497965000373	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
497965000374	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
497965000375	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497965000376	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
497965000377	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
497965000378	active site
497965000379	Riboflavin synthase alpha chain [Coenzyme metabolism]; Region: RibC; COG0307
497965000380	Lumazine binding domain; Region: Lum_binding; pfam00677
497965000381	Lumazine binding domain; Region: Lum_binding; pfam00677
497965000382	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
497965000383	dimer interface [polypeptide binding]; other site
497965000384	ADP-ribose binding site [chemical binding]; other site
497965000385	active site
497965000386	nudix motif; other site
497965000387	metal binding site [ion binding]; metal-binding site
497965000388	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
497965000389	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965000390	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000391	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000392	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000393	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000394	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000395	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
497965000396	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
497965000397	Active site cavity [active]
497965000398	catalytic acid [active]
497965000399	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
497965000400	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
497965000401	substrate binding site [chemical binding]; other site
497965000402	hexamer interface [polypeptide binding]; other site
497965000403	metal binding site [ion binding]; metal-binding site
497965000404	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
497965000405	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
497965000406	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
497965000407	HEAT repeats; Region: HEAT_2; pfam13646
497965000408	HEAT repeats; Region: HEAT_2; pfam13646
497965000409	HEAT repeats; Region: HEAT_2; pfam13646
497965000410	Uncharacterized conserved protein [Function unknown]; Region: COG1434
497965000411	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
497965000412	putative active site [active]
497965000413	ketol-acid reductoisomerase; Provisional; Region: PRK05479
497965000414	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
497965000415	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
497965000416	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
497965000417	C-terminal peptidase (prc); Region: prc; TIGR00225
497965000418	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
497965000419	protein binding site [polypeptide binding]; other site
497965000420	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
497965000421	Catalytic dyad [active]
497965000422	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
497965000423	active site
497965000424	catalytic site [active]
497965000425	substrate binding site [chemical binding]; other site
497965000426	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965000427	Probable transposase; Region: OrfB_IS605; pfam01385
497965000428	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965000429	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965000430	Coenzyme A binding pocket [chemical binding]; other site
497965000431	tellurium resistance terB-like protein; Region: terB_like; cd07177
497965000432	metal binding site [ion binding]; metal-binding site
497965000433	16S rRNA methyltransferase B; Provisional; Region: PRK14901
497965000434	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
497965000435	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965000436	S-adenosylmethionine binding site [chemical binding]; other site
497965000437	Uncharacterized conserved protein [Function unknown]; Region: COG1565
497965000438	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
497965000439	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
497965000440	dimer interface [polypeptide binding]; other site
497965000441	anticodon binding site; other site
497965000442	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
497965000443	homodimer interface [polypeptide binding]; other site
497965000444	motif 1; other site
497965000445	active site
497965000446	motif 2; other site
497965000447	GAD domain; Region: GAD; pfam02938
497965000448	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
497965000449	active site
497965000450	motif 3; other site
497965000451	Bacterial SH3 domain; Region: SH3_3; cl17532
497965000452	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965000453	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
497965000454	TPR motif; other site
497965000455	binding surface
497965000456	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965000457	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
497965000458	mce related protein; Region: MCE; pfam02470
497965000459	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
497965000460	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
497965000461	Walker A/P-loop; other site
497965000462	ATP binding site [chemical binding]; other site
497965000463	Q-loop/lid; other site
497965000464	ABC transporter signature motif; other site
497965000465	Walker B; other site
497965000466	D-loop; other site
497965000467	H-loop/switch region; other site
497965000468	TPR repeat; Region: TPR_11; pfam13414
497965000469	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965000470	binding surface
497965000471	TPR repeat; Region: TPR_11; pfam13414
497965000472	TPR motif; other site
497965000473	TPR repeat; Region: TPR_11; pfam13414
497965000474	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965000475	binding surface
497965000476	TPR motif; other site
497965000477	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
497965000478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965000479	ATP binding site [chemical binding]; other site
497965000480	Mg2+ binding site [ion binding]; other site
497965000481	G-X-G motif; other site
497965000482	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
497965000483	ATP binding site [chemical binding]; other site
497965000484	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
497965000485	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
497965000486	BON domain; Region: BON; pfam04972
497965000487	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
497965000488	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
497965000489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965000490	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965000491	active site
497965000492	phosphorylation site [posttranslational modification]
497965000493	intermolecular recognition site; other site
497965000494	dimerization interface [polypeptide binding]; other site
497965000495	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
497965000496	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
497965000497	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965000498	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
497965000499	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965000500	DNA binding residues [nucleotide binding]
497965000501	ferredoxin-sulfite reductase; Region: sir; TIGR02042
497965000502	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
497965000503	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
497965000504	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965000505	phosphopeptide binding site; other site
497965000506	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965000507	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965000508	phosphopeptide binding site; other site
497965000509	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
497965000510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965000511	Walker A/P-loop; other site
497965000512	ATP binding site [chemical binding]; other site
497965000513	Q-loop/lid; other site
497965000514	ABC transporter signature motif; other site
497965000515	Walker B; other site
497965000516	D-loop; other site
497965000517	H-loop/switch region; other site
497965000518	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
497965000519	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
497965000520	6-phosphofructokinase; Provisional; Region: PRK14071
497965000521	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
497965000522	active site
497965000523	ADP/pyrophosphate binding site [chemical binding]; other site
497965000524	dimerization interface [polypeptide binding]; other site
497965000525	allosteric effector site; other site
497965000526	fructose-1,6-bisphosphate binding site; other site
497965000527	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
497965000528	MPT binding site; other site
497965000529	trimer interface [polypeptide binding]; other site
497965000530	Psb28 protein; Region: Psb28; cl04326
497965000531	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
497965000532	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
497965000533	acyl-CoA synthetase; Validated; Region: PRK08162
497965000534	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
497965000535	acyl-activating enzyme (AAE) consensus motif; other site
497965000536	putative active site [active]
497965000537	AMP binding site [chemical binding]; other site
497965000538	putative CoA binding site [chemical binding]; other site
497965000539	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
497965000540	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
497965000541	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497965000542	catalytic residue [active]
497965000543	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965000544	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965000545	active site
497965000546	ATP binding site [chemical binding]; other site
497965000547	substrate binding site [chemical binding]; other site
497965000548	activation loop (A-loop); other site
497965000549	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
497965000550	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
497965000551	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
497965000552	P loop; other site
497965000553	GTP binding site [chemical binding]; other site
497965000554	GUN4-like; Region: GUN4; pfam05419
497965000555	transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634
497965000556	putative RNA binding site [nucleotide binding]; other site
497965000557	Uncharacterized conserved protein [Function unknown]; Region: COG2928
497965000558	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
497965000559	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
497965000560	putative active site [active]
497965000561	Double zinc ribbon; Region: DZR; pfam12773
497965000562	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
497965000563	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
497965000564	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965000565	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965000566	phosphopeptide binding site; other site
497965000567	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
497965000568	Peptidase family M50; Region: Peptidase_M50; pfam02163
497965000569	active site
497965000570	putative substrate binding region [chemical binding]; other site
497965000571	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
497965000572	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497965000573	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965000574	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
497965000575	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
497965000576	CHASE2 domain; Region: CHASE2; pfam05226
497965000577	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
497965000578	cyclase homology domain; Region: CHD; cd07302
497965000579	nucleotidyl binding site; other site
497965000580	metal binding site [ion binding]; metal-binding site
497965000581	dimer interface [polypeptide binding]; other site
497965000582	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
497965000583	Domain of unknown function (DUF427); Region: DUF427; pfam04248
497965000584	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
497965000585	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
497965000586	catalytic residues [active]
497965000587	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
497965000588	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
497965000589	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965000590	FeS/SAM binding site; other site
497965000591	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
497965000592	recombination protein F; Reviewed; Region: recF; PRK00064
497965000593	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
497965000594	Walker A/P-loop; other site
497965000595	ATP binding site [chemical binding]; other site
497965000596	Q-loop/lid; other site
497965000597	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965000598	ABC transporter signature motif; other site
497965000599	Walker B; other site
497965000600	D-loop; other site
497965000601	H-loop/switch region; other site
497965000602	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
497965000603	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
497965000604	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497965000605	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
497965000606	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965000607	motif II; other site
497965000608	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
497965000609	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965000610	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
497965000611	DXD motif; other site
497965000612	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
497965000613	GIY-YIG motif/motif A; other site
497965000614	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965000615	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965000616	active site
497965000617	ATP binding site [chemical binding]; other site
497965000618	substrate binding site [chemical binding]; other site
497965000619	activation loop (A-loop); other site
497965000620	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965000621	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000622	Uncharacterized protein family UPF0546; Region: UPF0546; pfam10639
497965000623	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965000624	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
497965000625	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
497965000626	putative NAD(P) binding site [chemical binding]; other site
497965000627	putative active site [active]
497965000628	Psb28 protein; Region: Psb28; pfam03912
497965000629	PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041
497965000630	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
497965000631	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
497965000632	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
497965000633	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
497965000634	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
497965000635	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
497965000636	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
497965000637	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
497965000638	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497965000639	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497965000640	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
497965000641	dimer interface [polypeptide binding]; other site
497965000642	active site
497965000643	Schiff base residues; other site
497965000644	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965000645	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000646	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965000647	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000648	Protein of unknown function DUF89; Region: DUF89; pfam01937
497965000649	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
497965000650	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
497965000651	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
497965000652	putative active site [active]
497965000653	catalytic residue [active]
497965000654	Circadian oscillating protein COP23; Region: COP23; pfam14218
497965000655	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965000656	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
497965000657	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965000658	TPR repeat; Region: TPR_11; pfam13414
497965000659	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965000660	binding surface
497965000661	TPR motif; other site
497965000662	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
497965000663	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965000664	TPR motif; other site
497965000665	binding surface
497965000666	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965000667	binding surface
497965000668	TPR motif; other site
497965000669	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
497965000670	nickel binding site [ion binding]; other site
497965000671	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
497965000672	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
497965000673	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
497965000674	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
497965000675	putative active site [active]
497965000676	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
497965000677	putative active site [active]
497965000678	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
497965000679	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965000680	binding surface
497965000681	TPR motif; other site
497965000682	TPR repeat; Region: TPR_11; pfam13414
497965000683	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965000684	PAS fold; Region: PAS_3; pfam08447
497965000685	putative active site [active]
497965000686	heme pocket [chemical binding]; other site
497965000687	PAS fold; Region: PAS_4; pfam08448
497965000688	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
497965000689	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965000690	dimer interface [polypeptide binding]; other site
497965000691	phosphorylation site [posttranslational modification]
497965000692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965000693	ATP binding site [chemical binding]; other site
497965000694	Mg2+ binding site [ion binding]; other site
497965000695	G-X-G motif; other site
497965000696	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
497965000697	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000698	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965000699	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000700	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965000701	RibD C-terminal domain; Region: RibD_C; cl17279
497965000702	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
497965000703	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
497965000704	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
497965000705	FMN binding site [chemical binding]; other site
497965000706	active site
497965000707	catalytic residues [active]
497965000708	substrate binding site [chemical binding]; other site
497965000709	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
497965000710	Coenzyme A binding pocket [chemical binding]; other site
497965000711	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
497965000712	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
497965000713	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
497965000714	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
497965000715	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
497965000716	RNA binding site [nucleotide binding]; other site
497965000717	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
497965000718	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965000719	structural tetrad; other site
497965000720	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965000721	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965000722	structural tetrad; other site
497965000723	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965000724	structural tetrad; other site
497965000725	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965000726	binding surface
497965000727	TPR motif; other site
497965000728	TPR repeat; Region: TPR_11; pfam13414
497965000729	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
497965000730	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
497965000731	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965000732	TPR repeat; Region: TPR_11; pfam13414
497965000733	binding surface
497965000734	TPR motif; other site
497965000735	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965000736	binding surface
497965000737	TPR motif; other site
497965000738	TPR repeat; Region: TPR_11; pfam13414
497965000739	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
497965000740	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
497965000741	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
497965000742	cytochrome b subunit interaction site [polypeptide binding]; other site
497965000743	[2Fe-2S] cluster binding site [ion binding]; other site
497965000744	apocytochrome f; Reviewed; Region: PRK02693
497965000745	cytochrome f; Region: petA; CHL00037
497965000746	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
497965000747	metal binding site 2 [ion binding]; metal-binding site
497965000748	putative DNA binding helix; other site
497965000749	metal binding site 1 [ion binding]; metal-binding site
497965000750	dimer interface [polypeptide binding]; other site
497965000751	structural Zn2+ binding site [ion binding]; other site
497965000752	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
497965000753	PQQ-like domain; Region: PQQ_2; pfam13360
497965000754	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
497965000755	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
497965000756	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
497965000757	Ligand Binding Site [chemical binding]; other site
497965000758	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965000759	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
497965000760	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965000761	FeS/SAM binding site; other site
497965000762	Protein of function (DUF2518); Region: DUF2518; pfam10726
497965000763	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
497965000764	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
497965000765	putative active site [active]
497965000766	metal binding site [ion binding]; metal-binding site
497965000767	hypothetical protein; Reviewed; Region: PRK12497
497965000768	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
497965000769	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
497965000770	G1 box; other site
497965000771	GTP/Mg2+ binding site [chemical binding]; other site
497965000772	Switch I region; other site
497965000773	G2 box; other site
497965000774	Switch II region; other site
497965000775	G3 box; other site
497965000776	G4 box; other site
497965000777	G5 box; other site
497965000778	Domain of unknown function (DUF697); Region: DUF697; pfam05128
497965000779	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965000780	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965000781	Probable transposase; Region: OrfB_IS605; pfam01385
497965000782	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
497965000783	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965000784	Q-loop/lid; other site
497965000785	Uncharacterized conserved protein [Function unknown]; Region: COG3339
497965000786	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
497965000787	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497965000788	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965000789	phosphopeptide binding site; other site
497965000790	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965000791	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965000792	phosphopeptide binding site; other site
497965000793	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
497965000794	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
497965000795	Walker A/P-loop; other site
497965000796	ATP binding site [chemical binding]; other site
497965000797	Q-loop/lid; other site
497965000798	ABC transporter signature motif; other site
497965000799	Walker B; other site
497965000800	D-loop; other site
497965000801	H-loop/switch region; other site
497965000802	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
497965000803	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
497965000804	LTXXQ motif family protein; Region: LTXXQ; pfam07813
497965000805	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
497965000806	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965000807	FeS/SAM binding site; other site
497965000808	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
497965000809	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497965000810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965000811	S-adenosylmethionine binding site [chemical binding]; other site
497965000812	EamA-like transporter family; Region: EamA; cl17759
497965000813	EamA-like transporter family; Region: EamA; pfam00892
497965000814	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
497965000815	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965000816	FeS/SAM binding site; other site
497965000817	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
497965000818	alanine racemase; Reviewed; Region: alr; PRK00053
497965000819	active site
497965000820	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
497965000821	dimer interface [polypeptide binding]; other site
497965000822	substrate binding site [chemical binding]; other site
497965000823	catalytic residues [active]
497965000824	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965000825	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965000826	active site
497965000827	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965000828	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965000829	dimer interface [polypeptide binding]; other site
497965000830	phosphorylation site [posttranslational modification]
497965000831	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965000832	ATP binding site [chemical binding]; other site
497965000833	Mg2+ binding site [ion binding]; other site
497965000834	G-X-G motif; other site
497965000835	aspartate aminotransferase; Provisional; Region: PRK05764
497965000836	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497965000837	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965000838	homodimer interface [polypeptide binding]; other site
497965000839	catalytic residue [active]
497965000840	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
497965000841	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965000842	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
497965000843	active site
497965000844	catalytic residues [active]
497965000845	DNA binding site [nucleotide binding]
497965000846	Int/Topo IB signature motif; other site
497965000847	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
497965000848	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
497965000849	active site residue [active]
497965000850	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
497965000851	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965000852	S-adenosylmethionine binding site [chemical binding]; other site
497965000853	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
497965000854	putative hydrophobic ligand binding site [chemical binding]; other site
497965000855	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497965000856	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497965000857	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497965000858	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
497965000859	putative C-terminal domain interface [polypeptide binding]; other site
497965000860	putative GSH binding site (G-site) [chemical binding]; other site
497965000861	putative dimer interface [polypeptide binding]; other site
497965000862	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
497965000863	putative N-terminal domain interface [polypeptide binding]; other site
497965000864	putative dimer interface [polypeptide binding]; other site
497965000865	putative substrate binding pocket (H-site) [chemical binding]; other site
497965000866	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
497965000867	Sulfatase; Region: Sulfatase; cl17466
497965000868	Domain of unknown function (DUF202); Region: DUF202; cl09954
497965000869	Protein of unknown function DUF262; Region: DUF262; pfam03235
497965000870	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
497965000871	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497965000872	catalytic loop [active]
497965000873	iron binding site [ion binding]; other site
497965000874	cobyric acid synthase; Provisional; Region: PRK00784
497965000875	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
497965000876	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
497965000877	catalytic triad [active]
497965000878	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
497965000879	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
497965000880	catalytic triad [active]
497965000881	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965000882	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965000883	active site
497965000884	phosphorylation site [posttranslational modification]
497965000885	intermolecular recognition site; other site
497965000886	dimerization interface [polypeptide binding]; other site
497965000887	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965000888	DNA binding site [nucleotide binding]
497965000889	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
497965000890	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
497965000891	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
497965000892	heme binding pocket [chemical binding]; other site
497965000893	heme ligand [chemical binding]; other site
497965000894	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965000895	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965000896	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965000897	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965000898	DNA binding residues [nucleotide binding]
497965000899	dimerization interface [polypeptide binding]; other site
497965000900	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
497965000901	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
497965000902	conserved cys residue [active]
497965000903	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
497965000904	Beta-lactamase; Region: Beta-lactamase; pfam00144
497965000905	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965000906	putative active site [active]
497965000907	DEAD-like helicases superfamily; Region: DEXDc; smart00487
497965000908	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965000909	ATP binding site [chemical binding]; other site
497965000910	putative Mg++ binding site [ion binding]; other site
497965000911	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965000912	nucleotide binding region [chemical binding]; other site
497965000913	ATP-binding site [chemical binding]; other site
497965000914	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
497965000915	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
497965000916	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
497965000917	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
497965000918	DevC protein; Region: devC; TIGR01185
497965000919	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
497965000920	FtsX-like permease family; Region: FtsX; pfam02687
497965000921	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
497965000922	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965000923	Protein of unknown function (DUF1702); Region: DUF1702; pfam08012
497965000924	Family description; Region: VCBS; pfam13517
497965000925	Family description; Region: VCBS; pfam13517
497965000926	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
497965000927	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965000928	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
497965000929	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
497965000930	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
497965000931	active site
497965000932	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
497965000933	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
497965000934	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
497965000935	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
497965000936	putative NADP binding site [chemical binding]; other site
497965000937	active site
497965000938	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
497965000939	active site 2 [active]
497965000940	active site 1 [active]
497965000941	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
497965000942	active site
497965000943	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
497965000944	RNase_H superfamily; Region: RNase_H_2; pfam13482
497965000945	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
497965000946	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
497965000947	peptide binding site [polypeptide binding]; other site
497965000948	dimer interface [polypeptide binding]; other site
497965000949	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
497965000950	dimer interface [polypeptide binding]; other site
497965000951	RNA polymerase sigma factor; Provisional; Region: PRK12518
497965000952	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965000953	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965000954	DNA binding residues [nucleotide binding]
497965000955	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965000956	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965000957	Probable transposase; Region: OrfB_IS605; pfam01385
497965000958	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965000959	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965000960	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965000961	active site
497965000962	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
497965000963	substrate binding site; other site
497965000964	dimer interface; other site
497965000965	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965000966	carotene isomerase; Region: carot_isom; TIGR02730
497965000967	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
497965000968	phosphoglycolate phosphatase; Provisional; Region: PRK13223
497965000969	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
497965000970	ribonuclease III; Reviewed; Region: rnc; PRK00102
497965000971	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
497965000972	dimerization interface [polypeptide binding]; other site
497965000973	active site
497965000974	metal binding site [ion binding]; metal-binding site
497965000975	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
497965000976	dsRNA binding site [nucleotide binding]; other site
497965000977	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
497965000978	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
497965000979	tandem repeat interface [polypeptide binding]; other site
497965000980	oligomer interface [polypeptide binding]; other site
497965000981	active site residues [active]
497965000982	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
497965000983	tandem repeat interface [polypeptide binding]; other site
497965000984	oligomer interface [polypeptide binding]; other site
497965000985	active site residues [active]
497965000986	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965000987	TPR motif; other site
497965000988	TPR repeat; Region: TPR_11; pfam13414
497965000989	binding surface
497965000990	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
497965000991	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497965000992	catalytic loop [active]
497965000993	iron binding site [ion binding]; other site
497965000994	Phycobilisome protein; Region: Phycobilisome; cl08227
497965000995	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
497965000996	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497965000997	catalytic loop [active]
497965000998	iron binding site [ion binding]; other site
497965000999	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
497965001000	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
497965001001	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
497965001002	V4R domain; Region: V4R; pfam02830
497965001003	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
497965001004	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
497965001005	putative NAD(P) binding site [chemical binding]; other site
497965001006	short chain dehydrogenase; Provisional; Region: PRK07063
497965001007	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965001008	NAD(P) binding site [chemical binding]; other site
497965001009	active site
497965001010	muropeptide transporter; Reviewed; Region: ampG; PRK11902
497965001011	muropeptide transporter; Validated; Region: ampG; cl17669
497965001012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965001013	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
497965001014	Peptidase family M50; Region: Peptidase_M50; pfam02163
497965001015	active site
497965001016	putative substrate binding region [chemical binding]; other site
497965001017	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
497965001018	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
497965001019	putative active site [active]
497965001020	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
497965001021	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
497965001022	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
497965001023	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
497965001024	photosystem I subunit VII; Region: psaC; CHL00065
497965001025	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
497965001026	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965001027	ligand binding site [chemical binding]; other site
497965001028	flexible hinge region; other site
497965001029	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
497965001030	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
497965001031	PYR/PP interface [polypeptide binding]; other site
497965001032	dimer interface [polypeptide binding]; other site
497965001033	TPP binding site [chemical binding]; other site
497965001034	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
497965001035	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
497965001036	TPP-binding site [chemical binding]; other site
497965001037	dimer interface [polypeptide binding]; other site
497965001038	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
497965001039	CpeS-like protein; Region: CpeS; pfam09367
497965001040	PAS fold; Region: PAS_4; pfam08448
497965001041	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965001042	putative active site [active]
497965001043	heme pocket [chemical binding]; other site
497965001044	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965001045	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965001046	putative active site [active]
497965001047	heme pocket [chemical binding]; other site
497965001048	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965001049	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965001050	putative active site [active]
497965001051	heme pocket [chemical binding]; other site
497965001052	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965001053	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965001054	putative active site [active]
497965001055	heme pocket [chemical binding]; other site
497965001056	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965001057	putative active site [active]
497965001058	heme pocket [chemical binding]; other site
497965001059	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965001060	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965001061	dimer interface [polypeptide binding]; other site
497965001062	phosphorylation site [posttranslational modification]
497965001063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965001064	ATP binding site [chemical binding]; other site
497965001065	Mg2+ binding site [ion binding]; other site
497965001066	G-X-G motif; other site
497965001067	Response regulator receiver domain; Region: Response_reg; pfam00072
497965001068	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965001069	active site
497965001070	phosphorylation site [posttranslational modification]
497965001071	intermolecular recognition site; other site
497965001072	dimerization interface [polypeptide binding]; other site
497965001073	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
497965001074	DNA methylase; Region: N6_N4_Mtase; pfam01555
497965001075	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
497965001076	lipoprotein signal peptidase; Provisional; Region: PRK14787
497965001077	BioY family; Region: BioY; pfam02632
497965001078	biotin synthase; Region: bioB; TIGR00433
497965001079	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965001080	FeS/SAM binding site; other site
497965001081	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
497965001082	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965001083	putative active site [active]
497965001084	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965001085	putative active site [active]
497965001086	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
497965001087	active site
497965001088	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
497965001089	protein binding site [polypeptide binding]; other site
497965001090	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
497965001091	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
497965001092	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
497965001093	minor groove reading motif; other site
497965001094	helix-hairpin-helix signature motif; other site
497965001095	substrate binding pocket [chemical binding]; other site
497965001096	active site
497965001097	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
497965001098	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965001099	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965001100	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
497965001101	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497965001102	Protein of unknown function (DUF3754); Region: DUF3754; pfam12576
497965001103	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965001104	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
497965001105	catalytic site [active]
497965001106	phosphoribulokinase; Provisional; Region: PRK07429
497965001107	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
497965001108	active site
497965001109	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
497965001110	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
497965001111	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
497965001112	dimerization interface [polypeptide binding]; other site
497965001113	FAD binding pocket [chemical binding]; other site
497965001114	FAD binding motif [chemical binding]; other site
497965001115	catalytic residues [active]
497965001116	NAD binding pocket [chemical binding]; other site
497965001117	phosphate binding motif [ion binding]; other site
497965001118	beta-alpha-beta structure motif; other site
497965001119	Late competence development protein ComFB; Region: ComFB; pfam10719
497965001120	cell division protein; Validated; Region: ftsH; CHL00176
497965001121	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965001122	Walker A motif; other site
497965001123	ATP binding site [chemical binding]; other site
497965001124	Walker B motif; other site
497965001125	arginine finger; other site
497965001126	Peptidase family M41; Region: Peptidase_M41; pfam01434
497965001127	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497965001128	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497965001129	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
497965001130	putative dimerization interface [polypeptide binding]; other site
497965001131	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
497965001132	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
497965001133	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
497965001134	Ligand binding site; other site
497965001135	Putative Catalytic site; other site
497965001136	DXD motif; other site
497965001137	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
497965001138	active site
497965001139	putative DNA-binding cleft [nucleotide binding]; other site
497965001140	dimer interface [polypeptide binding]; other site
497965001141	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
497965001142	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
497965001143	active site
497965001144	nucleophile elbow; other site
497965001145	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
497965001146	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
497965001147	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
497965001148	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
497965001149	active site
497965001150	iron coordination sites [ion binding]; other site
497965001151	substrate binding pocket [chemical binding]; other site
497965001152	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
497965001153	argininosuccinate synthase; Provisional; Region: PRK13820
497965001154	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
497965001155	ANP binding site [chemical binding]; other site
497965001156	Substrate Binding Site II [chemical binding]; other site
497965001157	Substrate Binding Site I [chemical binding]; other site
497965001158	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
497965001159	HEPN domain; Region: HEPN; cl00824
497965001160	AAA domain; Region: AAA_31; pfam13614
497965001161	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965001162	P-loop; other site
497965001163	Magnesium ion binding site [ion binding]; other site
497965001164	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
497965001165	MPN+ (JAMM) motif; other site
497965001166	Zinc-binding site [ion binding]; other site
497965001167	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
497965001168	oligomerisation interface [polypeptide binding]; other site
497965001169	mobile loop; other site
497965001170	roof hairpin; other site
497965001171	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
497965001172	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
497965001173	ring oligomerisation interface [polypeptide binding]; other site
497965001174	ATP/Mg binding site [chemical binding]; other site
497965001175	stacking interactions; other site
497965001176	hinge regions; other site
497965001177	transcriptional repressor DicA; Reviewed; Region: PRK09706
497965001178	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965001179	non-specific DNA binding site [nucleotide binding]; other site
497965001180	salt bridge; other site
497965001181	sequence-specific DNA binding site [nucleotide binding]; other site
497965001182	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
497965001183	Domain of unknown function (DUF955); Region: DUF955; pfam06114
497965001184	TIGR03790 family protein; Region: TIGR03790
497965001185	RRXRR protein; Region: RRXRR; pfam14239
497965001186	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
497965001187	septum formation inhibitor; Reviewed; Region: minC; PRK00513
497965001188	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
497965001189	septum site-determining protein MinD; Region: minD_bact; TIGR01968
497965001190	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
497965001191	Switch I; other site
497965001192	Switch II; other site
497965001193	cell division topological specificity factor MinE; Provisional; Region: PRK13988
497965001194	CAAX protease self-immunity; Region: Abi; pfam02517
497965001195	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
497965001196	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965001197	Coenzyme A binding pocket [chemical binding]; other site
497965001198	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
497965001199	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
497965001200	Walker A/P-loop; other site
497965001201	ATP binding site [chemical binding]; other site
497965001202	Q-loop/lid; other site
497965001203	ABC transporter signature motif; other site
497965001204	Walker B; other site
497965001205	D-loop; other site
497965001206	H-loop/switch region; other site
497965001207	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
497965001208	DevC protein; Region: devC; TIGR01185
497965001209	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
497965001210	FtsX-like permease family; Region: FtsX; pfam02687
497965001211	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
497965001212	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497965001213	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965001214	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497965001215	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497965001216	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
497965001217	short chain dehydrogenase; Provisional; Region: PRK06914
497965001218	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
497965001219	NADP binding site [chemical binding]; other site
497965001220	active site
497965001221	steroid binding site; other site
497965001222	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
497965001223	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
497965001224	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497965001225	catalytic residue [active]
497965001226	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965001227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965001228	active site
497965001229	phosphorylation site [posttranslational modification]
497965001230	intermolecular recognition site; other site
497965001231	dimerization interface [polypeptide binding]; other site
497965001232	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965001233	DNA binding residues [nucleotide binding]
497965001234	dimerization interface [polypeptide binding]; other site
497965001235	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965001236	HAMP domain; Region: HAMP; pfam00672
497965001237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965001238	dimer interface [polypeptide binding]; other site
497965001239	phosphorylation site [posttranslational modification]
497965001240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965001241	ATP binding site [chemical binding]; other site
497965001242	Mg2+ binding site [ion binding]; other site
497965001243	G-X-G motif; other site
497965001244	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965001245	phosphopeptide binding site; other site
497965001246	Transglycosylase; Region: Transgly; pfam00912
497965001247	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
497965001248	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
497965001249	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
497965001250	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
497965001251	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
497965001252	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
497965001253	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
497965001254	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497965001255	substrate binding pocket [chemical binding]; other site
497965001256	membrane-bound complex binding site; other site
497965001257	hinge residues; other site
497965001258	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
497965001259	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497965001260	active site
497965001261	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
497965001262	active site
497965001263	Zn2+ binding site [ion binding]; other site
497965001264	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
497965001265	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
497965001266	chorismate binding enzyme; Region: Chorismate_bind; cl10555
497965001267	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
497965001268	UbiA prenyltransferase family; Region: UbiA; pfam01040
497965001269	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
497965001270	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
497965001271	active site
497965001272	putative lithium-binding site [ion binding]; other site
497965001273	substrate binding site [chemical binding]; other site
497965001274	Peptidase family M48; Region: Peptidase_M48; cl12018
497965001275	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
497965001276	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
497965001277	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965001278	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965001279	metal binding site [ion binding]; metal-binding site
497965001280	active site
497965001281	I-site; other site
497965001282	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
497965001283	arginine-tRNA ligase; Region: PLN02286
497965001284	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
497965001285	active site
497965001286	HIGH motif; other site
497965001287	KMSK motif region; other site
497965001288	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
497965001289	tRNA binding surface [nucleotide binding]; other site
497965001290	anticodon binding site; other site
497965001291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965001292	S-adenosylmethionine binding site [chemical binding]; other site
497965001293	DEAD-like helicases superfamily; Region: DEXDc; smart00487
497965001294	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965001295	ATP binding site [chemical binding]; other site
497965001296	putative Mg++ binding site [ion binding]; other site
497965001297	Helicase_C-like; Region: Helicase_C_4; pfam13871
497965001298	CHAT domain; Region: CHAT; pfam12770
497965001299	AAA ATPase domain; Region: AAA_16; pfam13191
497965001300	GUN4-like; Region: GUN4; pfam05419
497965001301	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
497965001302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
497965001303	Protein of unknown function (DUF433); Region: DUF433; pfam04255
497965001304	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
497965001305	Mg binding site [ion binding]; other site
497965001306	nucleotide binding site [chemical binding]; other site
497965001307	putative protofilament interface [polypeptide binding]; other site
497965001308	RDD family; Region: RDD; pfam06271
497965001309	Protein of unknown function, DUF393; Region: DUF393; pfam04134
497965001310	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
497965001311	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
497965001312	active site
497965001313	interdomain interaction site; other site
497965001314	putative metal-binding site [ion binding]; other site
497965001315	nucleotide binding site [chemical binding]; other site
497965001316	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
497965001317	domain I; other site
497965001318	phosphate binding site [ion binding]; other site
497965001319	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
497965001320	domain II; other site
497965001321	domain III; other site
497965001322	nucleotide binding site [chemical binding]; other site
497965001323	DNA binding groove [nucleotide binding]
497965001324	catalytic site [active]
497965001325	domain IV; other site
497965001326	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
497965001327	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497965001328	active site
497965001329	metal binding site [ion binding]; metal-binding site
497965001330	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
497965001331	Domain of unknown function (DUF932); Region: DUF932; cl12129
497965001332	PemK-like protein; Region: PemK; pfam02452
497965001333	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
497965001334	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
497965001335	Transmembrane protein; Region: Macoilin; pfam09726
497965001336	Domain of unknown function DUF87; Region: DUF87; pfam01935
497965001337	AAA-like domain; Region: AAA_10; pfam12846
497965001338	Uncharacterized conserved protein [Function unknown]; Region: COG5464
497965001339	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
497965001340	active site
497965001341	catalytic triad [active]
497965001342	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
497965001343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965001344	Walker A motif; other site
497965001345	ATP binding site [chemical binding]; other site
497965001346	Walker B motif; other site
497965001347	arginine finger; other site
497965001348	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965001349	ATP binding site [chemical binding]; other site
497965001350	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
497965001351	putative Mg++ binding site [ion binding]; other site
497965001352	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
497965001353	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001354	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
497965001355	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001356	TPR motif; other site
497965001357	binding surface
497965001358	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001359	TPR motif; other site
497965001360	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
497965001361	binding surface
497965001362	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001363	binding surface
497965001364	TPR motif; other site
497965001365	magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407
497965001366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965001367	Walker A motif; other site
497965001368	ATP binding site [chemical binding]; other site
497965001369	Walker B motif; other site
497965001370	arginine finger; other site
497965001371	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
497965001372	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
497965001373	metal ion-dependent adhesion site (MIDAS); other site
497965001374	SEFIR domain; Region: SEFIR; pfam08357
497965001375	AAA ATPase domain; Region: AAA_16; pfam13191
497965001376	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001377	TPR motif; other site
497965001378	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001379	binding surface
497965001380	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001381	binding surface
497965001382	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001383	TPR motif; other site
497965001384	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001385	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001386	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001387	binding surface
497965001388	TPR motif; other site
497965001389	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001390	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001391	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001392	TPR motif; other site
497965001393	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001395	binding surface
497965001396	TPR motif; other site
497965001397	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001398	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
497965001399	binding surface
497965001400	TPR motif; other site
497965001401	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001402	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001403	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
497965001404	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
497965001405	SEFIR domain; Region: SEFIR; pfam08357
497965001406	AAA ATPase domain; Region: AAA_16; pfam13191
497965001407	NB-ARC domain; Region: NB-ARC; pfam00931
497965001408	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
497965001409	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
497965001410	Tetratricopeptide repeat; Region: TPR_10; pfam13374
497965001411	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001412	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001413	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001414	Tetratricopeptide repeat; Region: TPR_10; pfam13374
497965001415	CHAT domain; Region: CHAT; pfam12770
497965001416	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
497965001417	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
497965001418	TPR motif; other site
497965001419	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001420	binding surface
497965001421	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
497965001422	binding surface
497965001423	TPR motif; other site
497965001424	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965001425	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
497965001426	AAA domain; Region: AAA_30; pfam13604
497965001427	Family description; Region: UvrD_C_2; pfam13538
497965001428	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965001429	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
497965001430	ATP binding site [chemical binding]; other site
497965001431	putative Mg++ binding site [ion binding]; other site
497965001432	Prophage antirepressor [Transcription]; Region: COG3617
497965001433	BRO family, N-terminal domain; Region: Bro-N; smart01040
497965001434	GatB domain; Region: GatB_Yqey; cl17694
497965001435	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497965001436	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
497965001437	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965001438	active site
497965001439	catalytic residues [active]
497965001440	DNA binding site [nucleotide binding]
497965001441	Int/Topo IB signature motif; other site
497965001442	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
497965001443	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
497965001444	active site
497965001445	catalytic residues [active]
497965001446	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
497965001447	active site
497965001448	catalytic triad [active]
497965001449	oxyanion hole [active]
497965001450	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
497965001451	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
497965001452	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
497965001453	TrkA-N domain; Region: TrkA_N; pfam02254
497965001454	TrkA-C domain; Region: TrkA_C; pfam02080
497965001455	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
497965001456	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
497965001457	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497965001458	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965001459	S-adenosylmethionine binding site [chemical binding]; other site
497965001460	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
497965001461	metal binding site [ion binding]; metal-binding site
497965001462	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
497965001463	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
497965001464	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
497965001465	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
497965001466	dimer interface [polypeptide binding]; other site
497965001467	active site
497965001468	catalytic residue [active]
497965001469	metal binding site [ion binding]; metal-binding site
497965001470	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
497965001471	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
497965001472	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965001473	putative active site [active]
497965001474	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
497965001475	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
497965001476	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
497965001477	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
497965001478	putative dimer interface [polypeptide binding]; other site
497965001479	N-terminal domain interface [polypeptide binding]; other site
497965001480	putative substrate binding pocket (H-site) [chemical binding]; other site
497965001481	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
497965001482	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965001483	FeS/SAM binding site; other site
497965001484	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
497965001485	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965001486	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965001487	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965001488	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965001489	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965001490	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965001491	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
497965001492	ligand binding site [chemical binding]; other site
497965001493	flexible hinge region; other site
497965001494	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
497965001495	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
497965001496	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
497965001497	NIL domain; Region: NIL; cl09633
497965001498	sulfate transport protein; Provisional; Region: cysT; CHL00187
497965001499	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965001500	dimer interface [polypeptide binding]; other site
497965001501	conserved gate region; other site
497965001502	putative PBP binding loops; other site
497965001503	ABC-ATPase subunit interface; other site
497965001504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965001505	dimer interface [polypeptide binding]; other site
497965001506	conserved gate region; other site
497965001507	putative PBP binding loops; other site
497965001508	ABC-ATPase subunit interface; other site
497965001509	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
497965001510	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
497965001511	Walker A/P-loop; other site
497965001512	ATP binding site [chemical binding]; other site
497965001513	Q-loop/lid; other site
497965001514	ABC transporter signature motif; other site
497965001515	Walker B; other site
497965001516	D-loop; other site
497965001517	H-loop/switch region; other site
497965001518	TOBE-like domain; Region: TOBE_3; pfam12857
497965001519	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
497965001520	putative active site [active]
497965001521	catalytic site [active]
497965001522	NACHT domain; Region: NACHT; pfam05729
497965001523	GUN4-like; Region: GUN4; pfam05419
497965001524	Uncharacterized conserved protein [Function unknown]; Region: COG1262
497965001525	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
497965001526	Probable transposase; Region: OrfB_IS605; pfam01385
497965001527	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965001528	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
497965001529	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965001530	putative active site [active]
497965001531	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
497965001532	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
497965001533	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
497965001534	dimer interface [polypeptide binding]; other site
497965001535	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
497965001536	active site
497965001537	Fe binding site [ion binding]; other site
497965001538	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
497965001539	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
497965001540	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
497965001541	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
497965001542	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
497965001543	DAK2 domain; Region: Dak2; cl03685
497965001544	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
497965001545	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965001546	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
497965001547	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965001548	Walker A motif; other site
497965001549	ATP binding site [chemical binding]; other site
497965001550	ChaB; Region: ChaB; pfam06150
497965001551	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
497965001552	classical (c) SDRs; Region: SDR_c; cd05233
497965001553	NAD(P) binding site [chemical binding]; other site
497965001554	active site
497965001555	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
497965001556	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
497965001557	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
497965001558	trimer interface [polypeptide binding]; other site
497965001559	active site
497965001560	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
497965001561	catalytic site [active]
497965001562	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
497965001563	putative active site [active]
497965001564	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965001565	Ca2+ binding site [ion binding]; other site
497965001566	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965001567	Ca2+ binding site [ion binding]; other site
497965001568	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965001569	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965001570	Ca2+ binding site [ion binding]; other site
497965001571	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
497965001572	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
497965001573	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
497965001574	active site
497965001575	SAM binding site [chemical binding]; other site
497965001576	homodimer interface [polypeptide binding]; other site
497965001577	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
497965001578	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
497965001579	active site
497965001580	homodimer interface [polypeptide binding]; other site
497965001581	catalytic site [active]
497965001582	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965001583	putative active site [active]
497965001584	proline aminopeptidase P II; Provisional; Region: PRK10879
497965001585	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
497965001586	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
497965001587	active site
497965001588	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
497965001589	Cytochrome P450; Region: p450; cl12078
497965001590	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
497965001591	Calx-beta domain; Region: Calx-beta; pfam03160
497965001592	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
497965001593	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
497965001594	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
497965001595	putative ADP-binding pocket [chemical binding]; other site
497965001596	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
497965001597	Thioredoxin; Region: Thioredoxin_4; cl17273
497965001598	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
497965001599	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
497965001600	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
497965001601	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
497965001602	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
497965001603	putative NAD(P) binding site [chemical binding]; other site
497965001604	active site
497965001605	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
497965001606	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
497965001607	homotrimer interaction site [polypeptide binding]; other site
497965001608	zinc binding site [ion binding]; other site
497965001609	CDP-binding sites; other site
497965001610	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
497965001611	active site
497965001612	catalytic motif [active]
497965001613	Zn binding site [ion binding]; other site
497965001614	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965001615	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497965001616	Amidohydrolase; Region: Amidohydro_2; pfam04909
497965001617	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
497965001618	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
497965001619	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
497965001620	YcaO-like family; Region: YcaO; pfam02624
497965001621	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
497965001622	Amidohydrolase; Region: Amidohydro_2; pfam04909
497965001623	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965001624	active site
497965001625	ATP binding site [chemical binding]; other site
497965001626	substrate binding site [chemical binding]; other site
497965001627	activation loop (A-loop); other site
497965001628	AAA ATPase domain; Region: AAA_16; pfam13191
497965001629	Predicted ATPase [General function prediction only]; Region: COG3899
497965001630	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965001631	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965001632	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965001633	Walker A motif; other site
497965001634	ATP binding site [chemical binding]; other site
497965001635	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001636	binding surface
497965001637	TPR repeat; Region: TPR_11; pfam13414
497965001638	TPR motif; other site
497965001639	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001640	TPR motif; other site
497965001641	binding surface
497965001642	TPR repeat; Region: TPR_11; pfam13414
497965001643	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001644	binding surface
497965001645	TPR motif; other site
497965001646	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
497965001647	binding surface
497965001648	TPR motif; other site
497965001649	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
497965001650	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965001651	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965001652	DNA binding residues [nucleotide binding]
497965001653	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
497965001654	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
497965001655	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497965001656	putative di-iron ligands [ion binding]; other site
497965001657	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497965001658	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
497965001659	putative di-iron ligands [ion binding]; other site
497965001660	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
497965001661	ABC1 family; Region: ABC1; pfam03109
497965001662	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
497965001663	active site
497965001664	ATP binding site [chemical binding]; other site
497965001665	HupF/HypC family; Region: HupF_HypC; pfam01455
497965001666	Acylphosphatase; Region: Acylphosphatase; pfam00708
497965001667	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
497965001668	HypF finger; Region: zf-HYPF; pfam07503
497965001669	HypF finger; Region: zf-HYPF; pfam07503
497965001670	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
497965001671	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
497965001672	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
497965001673	dimerization interface [polypeptide binding]; other site
497965001674	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
497965001675	ATP binding site [chemical binding]; other site
497965001676	SecA DEAD-like domain; Region: SecA_DEAD; smart00957
497965001677	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
497965001678	Cation efflux family; Region: Cation_efflux; pfam01545
497965001679	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
497965001680	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
497965001681	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
497965001682	Walker A/P-loop; other site
497965001683	ATP binding site [chemical binding]; other site
497965001684	Q-loop/lid; other site
497965001685	ABC transporter signature motif; other site
497965001686	Walker B; other site
497965001687	D-loop; other site
497965001688	H-loop/switch region; other site
497965001689	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
497965001690	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
497965001691	Walker A/P-loop; other site
497965001692	ATP binding site [chemical binding]; other site
497965001693	Q-loop/lid; other site
497965001694	ABC transporter signature motif; other site
497965001695	Walker B; other site
497965001696	D-loop; other site
497965001697	H-loop/switch region; other site
497965001698	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
497965001699	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
497965001700	TM-ABC transporter signature motif; other site
497965001701	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
497965001702	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
497965001703	TM-ABC transporter signature motif; other site
497965001704	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
497965001705	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
497965001706	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
497965001707	PRC-barrel domain; Region: PRC; pfam05239
497965001708	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
497965001709	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965001710	Walker A motif; other site
497965001711	ATP binding site [chemical binding]; other site
497965001712	Walker B motif; other site
497965001713	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
497965001714	4Fe-4S binding domain; Region: Fer4_5; pfam12801
497965001715	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
497965001716	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
497965001717	Na binding site [ion binding]; other site
497965001718	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965001719	dimerization interface [polypeptide binding]; other site
497965001720	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
497965001721	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
497965001722	dimer interface [polypeptide binding]; other site
497965001723	putative CheW interface [polypeptide binding]; other site
497965001724	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
497965001725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965001726	S-adenosylmethionine binding site [chemical binding]; other site
497965001727	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001728	binding surface
497965001729	Tetratricopeptide repeat; Region: TPR_16; pfam13432
497965001730	TPR motif; other site
497965001731	CheW-like domain; Region: CheW; pfam01584
497965001732	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
497965001733	active site
497965001734	catalytic residues [active]
497965001735	metal binding site [ion binding]; metal-binding site
497965001736	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
497965001737	putative active site [active]
497965001738	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
497965001739	N-acetyl-D-glucosamine binding site [chemical binding]; other site
497965001740	catalytic residue [active]
497965001741	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
497965001742	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
497965001743	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965001744	salt bridge; other site
497965001745	non-specific DNA binding site [nucleotide binding]; other site
497965001746	sequence-specific DNA binding site [nucleotide binding]; other site
497965001747	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497965001748	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965001749	non-specific DNA binding site [nucleotide binding]; other site
497965001750	salt bridge; other site
497965001751	sequence-specific DNA binding site [nucleotide binding]; other site
497965001752	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
497965001753	active site
497965001754	GIY-YIG motif/motif A; other site
497965001755	catalytic site [active]
497965001756	metal binding site [ion binding]; metal-binding site
497965001757	Gypsy protein; Region: Gypsy; pfam07253
497965001758	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
497965001759	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497965001760	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965001761	active site
497965001762	catalytic residues [active]
497965001763	DNA binding site [nucleotide binding]
497965001764	Int/Topo IB signature motif; other site
497965001765	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
497965001766	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
497965001767	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965001768	non-specific DNA binding site [nucleotide binding]; other site
497965001769	salt bridge; other site
497965001770	sequence-specific DNA binding site [nucleotide binding]; other site
497965001771	HsdM N-terminal domain; Region: HsdM_N; pfam12161
497965001772	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
497965001773	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965001774	S-adenosylmethionine binding site [chemical binding]; other site
497965001775	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
497965001776	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
497965001777	Abortive infection C-terminus; Region: Abi_C; pfam14355
497965001778	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
497965001779	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
497965001780	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965001781	ATP binding site [chemical binding]; other site
497965001782	putative Mg++ binding site [ion binding]; other site
497965001783	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
497965001784	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
497965001785	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
497965001786	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
497965001787	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
497965001788	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
497965001789	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
497965001790	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965001791	Radical SAM superfamily; Region: Radical_SAM; pfam04055
497965001792	FeS/SAM binding site; other site
497965001793	DEAD-like helicases superfamily; Region: DEXDc; smart00487
497965001794	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965001795	ATP binding site [chemical binding]; other site
497965001796	putative Mg++ binding site [ion binding]; other site
497965001797	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965001798	nucleotide binding region [chemical binding]; other site
497965001799	ATP-binding site [chemical binding]; other site
497965001800	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
497965001801	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
497965001802	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965001803	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
497965001804	DNA polymerase I; Provisional; Region: PRK05755
497965001805	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
497965001806	active site
497965001807	metal binding site 1 [ion binding]; metal-binding site
497965001808	putative 5' ssDNA interaction site; other site
497965001809	metal binding site 3; metal-binding site
497965001810	metal binding site 2 [ion binding]; metal-binding site
497965001811	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
497965001812	putative DNA binding site [nucleotide binding]; other site
497965001813	putative metal binding site [ion binding]; other site
497965001814	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
497965001815	active site
497965001816	catalytic site [active]
497965001817	substrate binding site [chemical binding]; other site
497965001818	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
497965001819	active site
497965001820	DNA binding site [nucleotide binding]
497965001821	catalytic site [active]
497965001822	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
497965001823	PBP superfamily domain; Region: PBP_like_2; pfam12849
497965001824	TPR repeat; Region: TPR_11; pfam13414
497965001825	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965001826	binding surface
497965001827	TPR motif; other site
497965001828	Tetratricopeptide repeat; Region: TPR_16; pfam13432
497965001829	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
497965001830	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
497965001831	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
497965001832	Chain length determinant protein; Region: Wzz; pfam02706
497965001833	AAA domain; Region: AAA_31; pfam13614
497965001834	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
497965001835	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
497965001836	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
497965001837	SLBB domain; Region: SLBB; pfam10531
497965001838	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
497965001839	SLBB domain; Region: SLBB; pfam10531
497965001840	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
497965001841	Predicted GTPase [General function prediction only]; Region: COG3596
497965001842	YfjP GTPase; Region: YfjP; cd11383
497965001843	G1 box; other site
497965001844	GTP/Mg2+ binding site [chemical binding]; other site
497965001845	Switch I region; other site
497965001846	G2 box; other site
497965001847	Switch II region; other site
497965001848	G3 box; other site
497965001849	G4 box; other site
497965001850	TIR domain; Region: TIR_2; pfam13676
497965001851	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
497965001852	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
497965001853	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
497965001854	active site
497965001855	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
497965001856	Peptidase family M50; Region: Peptidase_M50; pfam02163
497965001857	active site
497965001858	putative substrate binding region [chemical binding]; other site
497965001859	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
497965001860	Uncharacterized conserved protein [Function unknown]; Region: COG1359
497965001861	Nidogen-like; Region: NIDO; cl02648
497965001862	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965001863	Nidogen-like; Region: NIDO; cl02648
497965001864	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965001865	Protein of unknown function (DUF751); Region: DUF751; pfam05421
497965001866	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
497965001867	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
497965001868	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
497965001869	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
497965001870	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965001871	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
497965001872	substrate binding site [chemical binding]; other site
497965001873	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
497965001874	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
497965001875	active site residue [active]
497965001876	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
497965001877	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
497965001878	Protein of Unknown function (DUF1690); Region: DUF1690; pfam07956
497965001879	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
497965001880	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965001881	putative active site [active]
497965001882	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
497965001883	active site
497965001884	dimer interface [polypeptide binding]; other site
497965001885	catalytic nucleophile [active]
497965001886	Circadian oscillating protein COP23; Region: COP23; pfam14218
497965001887	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
497965001888	Amidinotransferase; Region: Amidinotransf; cl12043
497965001889	Uncharacterized conserved protein [Function unknown]; Region: COG1915
497965001890	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
497965001891	homodimer interface [polypeptide binding]; other site
497965001892	HEAT repeats; Region: HEAT_2; pfam13646
497965001893	toxin interface [polypeptide binding]; other site
497965001894	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
497965001895	Zn binding site [ion binding]; other site
497965001896	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
497965001897	Protein of unknown function DUF262; Region: DUF262; pfam03235
497965001898	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
497965001899	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
497965001900	substrate binding site [chemical binding]; other site
497965001901	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
497965001902	substrate binding site [chemical binding]; other site
497965001903	ligand binding site [chemical binding]; other site
497965001904	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
497965001905	XisH protein; Region: XisH; pfam08814
497965001906	XisI protein; Region: XisI; pfam08869
497965001907	toxin interface [polypeptide binding]; other site
497965001908	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
497965001909	Zn binding site [ion binding]; other site
497965001910	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
497965001911	acetyl-CoA synthetase; Provisional; Region: PRK00174
497965001912	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
497965001913	active site
497965001914	CoA binding site [chemical binding]; other site
497965001915	acyl-activating enzyme (AAE) consensus motif; other site
497965001916	AMP binding site [chemical binding]; other site
497965001917	acetate binding site [chemical binding]; other site
497965001918	cyanate hydratase; Validated; Region: PRK02866
497965001919	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
497965001920	oligomer interface [polypeptide binding]; other site
497965001921	active site
497965001922	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
497965001923	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965001924	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965001925	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965001926	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965001927	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965001928	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965001929	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965001930	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
497965001931	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
497965001932	DNA-binding interface [nucleotide binding]; DNA binding site
497965001933	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
497965001934	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
497965001935	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
497965001936	catalytic site [active]
497965001937	subunit interface [polypeptide binding]; other site
497965001938	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
497965001939	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
497965001940	anti sigma factor interaction site; other site
497965001941	regulatory phosphorylation site [posttranslational modification]; other site
497965001942	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
497965001943	dimerization interface [polypeptide binding]; other site
497965001944	active site
497965001945	metal binding site [ion binding]; metal-binding site
497965001946	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
497965001947	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
497965001948	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
497965001949	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
497965001950	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965001951	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
497965001952	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
497965001953	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965001954	active site
497965001955	motif I; other site
497965001956	motif II; other site
497965001957	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965001958	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
497965001959	cobalamin synthase; Reviewed; Region: cobS; PRK00235
497965001960	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
497965001961	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
497965001962	RRXRR protein; Region: RRXRR; pfam14239
497965001963	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
497965001964	alpha-glucosidase; Provisional; Region: PRK10137
497965001965	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
497965001966	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
497965001967	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
497965001968	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
497965001969	substrate binding pocket [chemical binding]; other site
497965001970	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
497965001971	B12 binding site [chemical binding]; other site
497965001972	cobalt ligand [ion binding]; other site
497965001973	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
497965001974	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
497965001975	Tellurite resistance protein TerB; Region: TerB; cl17311
497965001976	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965001977	putative active site [active]
497965001978	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
497965001979	Leucine-rich repeats; other site
497965001980	Leucine rich repeat; Region: LRR_8; pfam13855
497965001981	Substrate binding site [chemical binding]; other site
497965001982	Leucine rich repeat; Region: LRR_8; pfam13855
497965001983	Leucine rich repeat; Region: LRR_8; pfam13855
497965001984	Leucine rich repeat; Region: LRR_8; pfam13855
497965001985	Leucine rich repeat; Region: LRR_8; pfam13855
497965001986	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
497965001987	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
497965001988	G1 box; other site
497965001989	GTP/Mg2+ binding site [chemical binding]; other site
497965001990	G2 box; other site
497965001991	Switch I region; other site
497965001992	G3 box; other site
497965001993	Switch II region; other site
497965001994	G4 box; other site
497965001995	G5 box; other site
497965001996	Alphavirus E1 glycoprotein; Region: Alpha_E1_glycop; pfam01589
497965001997	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
497965001998	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
497965001999	putative ADP-binding pocket [chemical binding]; other site
497965002000	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
497965002001	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
497965002002	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
497965002003	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
497965002004	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
497965002005	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965002006	putative active site [active]
497965002007	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
497965002008	RNA/DNA hybrid binding site [nucleotide binding]; other site
497965002009	active site
497965002010	Helix-turn-helix domain; Region: HTH_25; pfam13413
497965002011	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
497965002012	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
497965002013	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
497965002014	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
497965002015	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497965002016	NACHT domain; Region: NACHT; pfam05729
497965002017	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cd01120
497965002018	Walker A motif; other site
497965002019	ATP binding site [chemical binding]; other site
497965002020	Walker B motif; other site
497965002021	HEAT repeats; Region: HEAT_2; pfam13646
497965002022	HEAT repeats; Region: HEAT_2; pfam13646
497965002023	HEAT repeats; Region: HEAT_2; pfam13646
497965002024	HEAT repeats; Region: HEAT_2; pfam13646
497965002025	HEAT repeats; Region: HEAT_2; pfam13646
497965002026	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
497965002027	TrkA-N domain; Region: TrkA_N; pfam02254
497965002028	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
497965002029	TrkA-N domain; Region: TrkA_N; pfam02254
497965002030	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
497965002031	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
497965002032	active site
497965002033	HIGH motif; other site
497965002034	nucleotide binding site [chemical binding]; other site
497965002035	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
497965002036	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
497965002037	active site
497965002038	KMSKS motif; other site
497965002039	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
497965002040	tRNA binding surface [nucleotide binding]; other site
497965002041	anticodon binding site; other site
497965002042	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
497965002043	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
497965002044	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
497965002045	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497965002046	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
497965002047	PemK-like protein; Region: PemK; pfam02452
497965002048	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
497965002049	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965002050	Protein of unknown function DUF262; Region: DUF262; pfam03235
497965002051	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
497965002052	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
497965002053	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
497965002054	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965002055	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965002056	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965002057	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965002058	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965002059	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965002060	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965002061	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
497965002062	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
497965002063	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
497965002064	glutaminase active site [active]
497965002065	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
497965002066	dimer interface [polypeptide binding]; other site
497965002067	active site
497965002068	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
497965002069	dimer interface [polypeptide binding]; other site
497965002070	active site
497965002071	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965002072	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
497965002073	dimer interface [polypeptide binding]; other site
497965002074	[2Fe-2S] cluster binding site [ion binding]; other site
497965002075	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
497965002076	MoaE homodimer interface [polypeptide binding]; other site
497965002077	MoaD interaction [polypeptide binding]; other site
497965002078	active site residues [active]
497965002079	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
497965002080	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
497965002081	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
497965002082	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
497965002083	GUN4-like; Region: GUN4; pfam05419
497965002084	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
497965002085	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
497965002086	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965002087	proton extrusion protein PcxA; Provisional; Region: PRK02507
497965002088	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
497965002089	Protein export membrane protein; Region: SecD_SecF; cl14618
497965002090	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
497965002091	RNA binding site [nucleotide binding]; other site
497965002092	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
497965002093	catalytic residue [active]
497965002094	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
497965002095	Virulence-associated protein E; Region: VirE; pfam05272
497965002096	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965002097	non-specific DNA binding site [nucleotide binding]; other site
497965002098	salt bridge; other site
497965002099	sequence-specific DNA binding site [nucleotide binding]; other site
497965002100	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
497965002101	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
497965002102	DNA binding residues [nucleotide binding]
497965002103	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965002104	active site
497965002105	catalytic residues [active]
497965002106	DNA binding site [nucleotide binding]
497965002107	Int/Topo IB signature motif; other site
497965002108	Helix-turn-helix domain; Region: HTH_17; cl17695
497965002109	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
497965002110	Prophage antirepressor [Transcription]; Region: COG3617
497965002111	BRO family, N-terminal domain; Region: Bro-N; smart01040
497965002112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
497965002113	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
497965002114	Zeta toxin; Region: Zeta_toxin; pfam06414
497965002115	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965002116	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965002117	active site
497965002118	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
497965002119	PKC phosphorylation site [posttranslational modification]; other site
497965002120	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965002121	Cadherin repeat-like domain; Region: CA_like; cl15786
497965002122	Ca2+ binding site [ion binding]; other site
497965002123	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965002124	Cadherin repeat-like domain; Region: CA_like; cl15786
497965002125	Ca2+ binding site [ion binding]; other site
497965002126	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
497965002127	ligand binding surface [chemical binding]; other site
497965002128	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
497965002129	ligand binding surface [chemical binding]; other site
497965002130	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497965002131	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497965002132	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497965002133	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
497965002134	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
497965002135	Double zinc ribbon; Region: DZR; pfam12773
497965002136	Protein kinase domain; Region: Pkinase; pfam00069
497965002137	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965002138	active site
497965002139	ATP binding site [chemical binding]; other site
497965002140	substrate binding site [chemical binding]; other site
497965002141	activation loop (A-loop); other site
497965002142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965002143	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
497965002144	Walker A motif; other site
497965002145	ATP binding site [chemical binding]; other site
497965002146	Walker B motif; other site
497965002147	arginine finger; other site
497965002148	Caspase domain; Region: Peptidase_C14; pfam00656
497965002149	Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340
497965002150	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
497965002151	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
497965002152	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
497965002153	Chain length determinant protein; Region: Wzz; cl15801
497965002154	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
497965002155	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
497965002156	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
497965002157	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965002158	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965002159	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
497965002160	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Region: SpoIIAA; COG1366
497965002161	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
497965002162	Bacterial sugar transferase; Region: Bac_transf; pfam02397
497965002163	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
497965002164	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965002165	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
497965002166	active site
497965002167	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
497965002168	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
497965002169	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
497965002170	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965002171	Walker A motif; other site
497965002172	ATP binding site [chemical binding]; other site
497965002173	Walker B motif; other site
497965002174	arginine finger; other site
497965002175	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
497965002176	active site
497965002177	catalytic triad [active]
497965002178	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
497965002179	Helix-turn-helix domain; Region: HTH_37; pfam13744
497965002180	Uncharacterized conserved protein [Function unknown]; Region: COG2442
497965002181	Uncharacterized conserved protein [Function unknown]; Region: COG5464
497965002182	Domain of unknown function DUF87; Region: DUF87; pfam01935
497965002183	AAA-like domain; Region: AAA_10; pfam12846
497965002184	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
497965002185	Pneumovirinae attachment membrane glycoprotein G; Region: Pneumo_att_G; pfam05539
497965002186	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
497965002187	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
497965002188	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
497965002189	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
497965002190	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
497965002191	Clp amino terminal domain; Region: Clp_N; pfam02861
497965002192	Clp amino terminal domain; Region: Clp_N; pfam02861
497965002193	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
497965002194	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002195	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002196	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002197	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002198	TPR motif; other site
497965002199	binding surface
497965002200	CHAT domain; Region: CHAT; pfam12770
497965002201	Protein of unknown function, DUF393; Region: DUF393; pfam04134
497965002202	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
497965002203	Mg binding site [ion binding]; other site
497965002204	nucleotide binding site [chemical binding]; other site
497965002205	putative protofilament interface [polypeptide binding]; other site
497965002206	Protein of unknown function (DUF433); Region: DUF433; pfam04255
497965002207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965002208	S-adenosylmethionine binding site [chemical binding]; other site
497965002209	DEAD-like helicases superfamily; Region: DEXDc; smart00487
497965002210	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965002211	ATP binding site [chemical binding]; other site
497965002212	putative Mg++ binding site [ion binding]; other site
497965002213	Helicase_C-like; Region: Helicase_C_4; pfam13871
497965002214	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
497965002215	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
497965002216	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965002217	active site
497965002218	catalytic residues [active]
497965002219	DNA binding site [nucleotide binding]
497965002220	Int/Topo IB signature motif; other site
497965002221	Clp protease ATP binding subunit; Region: clpC; CHL00095
497965002222	Clp amino terminal domain; Region: Clp_N; pfam02861
497965002223	Clp amino terminal domain; Region: Clp_N; pfam02861
497965002224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965002225	Walker A motif; other site
497965002226	ATP binding site [chemical binding]; other site
497965002227	Walker B motif; other site
497965002228	arginine finger; other site
497965002229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965002230	Walker A motif; other site
497965002231	ATP binding site [chemical binding]; other site
497965002232	Walker B motif; other site
497965002233	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
497965002234	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
497965002235	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
497965002236	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497965002237	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965002238	DevC protein; Region: devC; TIGR01185
497965002239	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
497965002240	FtsX-like permease family; Region: FtsX; pfam02687
497965002241	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
497965002242	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
497965002243	Walker A/P-loop; other site
497965002244	ATP binding site [chemical binding]; other site
497965002245	Q-loop/lid; other site
497965002246	ABC transporter signature motif; other site
497965002247	Walker B; other site
497965002248	D-loop; other site
497965002249	H-loop/switch region; other site
497965002250	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965002251	putative active site [active]
497965002252	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965002253	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
497965002254	protein I interface; other site
497965002255	D2 interface; other site
497965002256	protein T interface; other site
497965002257	chlorophyll binding site; other site
497965002258	beta carotene binding site; other site
497965002259	pheophytin binding site; other site
497965002260	manganese-stabilizing polypeptide interface; other site
497965002261	CP43 interface; other site
497965002262	protein L interface; other site
497965002263	oxygen evolving complex binding site; other site
497965002264	bromide binding site; other site
497965002265	quinone binding site; other site
497965002266	Fe binding site [ion binding]; other site
497965002267	core light harvesting interface; other site
497965002268	cytochrome b559 alpha subunit interface; other site
497965002269	cytochrome c-550 interface; other site
497965002270	protein J interface; other site
497965002271	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
497965002272	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
497965002273	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497965002274	catalytic residue [active]
497965002275	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
497965002276	Uncharacterized conserved protein [Function unknown]; Region: COG0393
497965002277	CHASE2 domain; Region: CHASE2; pfam05226
497965002278	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
497965002279	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965002280	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965002281	active site
497965002282	ATP binding site [chemical binding]; other site
497965002283	substrate binding site [chemical binding]; other site
497965002284	activation loop (A-loop); other site
497965002285	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
497965002286	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497965002287	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
497965002288	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
497965002289	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
497965002290	catalytic triad [active]
497965002291	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
497965002292	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
497965002293	TPP-binding site; other site
497965002294	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
497965002295	PYR/PP interface [polypeptide binding]; other site
497965002296	dimer interface [polypeptide binding]; other site
497965002297	TPP binding site [chemical binding]; other site
497965002298	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
497965002299	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
497965002300	amphipathic channel; other site
497965002301	Asn-Pro-Ala signature motifs; other site
497965002302	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
497965002303	Cytochrome P450; Region: p450; cl12078
497965002304	TPR repeat; Region: TPR_11; pfam13414
497965002305	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002306	binding surface
497965002307	TPR motif; other site
497965002308	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
497965002309	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
497965002310	elongation factor G; Reviewed; Region: PRK00007
497965002311	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
497965002312	G1 box; other site
497965002313	putative GEF interaction site [polypeptide binding]; other site
497965002314	GTP/Mg2+ binding site [chemical binding]; other site
497965002315	Switch I region; other site
497965002316	G2 box; other site
497965002317	G3 box; other site
497965002318	Switch II region; other site
497965002319	G4 box; other site
497965002320	G5 box; other site
497965002321	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
497965002322	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
497965002323	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
497965002324	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
497965002325	CAAX protease self-immunity; Region: Abi; pfam02517
497965002326	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002327	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002328	binding surface
497965002329	TPR motif; other site
497965002330	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002331	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002332	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002333	Tetratricopeptide repeat; Region: TPR_10; pfam13374
497965002334	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002335	binding surface
497965002336	TPR motif; other site
497965002337	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002338	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002339	Tetratricopeptide repeat; Region: TPR_10; pfam13374
497965002340	CHAT domain; Region: CHAT; pfam12770
497965002341	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
497965002342	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
497965002343	active site
497965002344	catalytic triad [active]
497965002345	oxyanion hole [active]
497965002346	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965002347	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
497965002348	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
497965002349	dimerization interface [polypeptide binding]; other site
497965002350	active site
497965002351	metal binding site [ion binding]; metal-binding site
497965002352	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
497965002353	dsRNA binding site [nucleotide binding]; other site
497965002354	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
497965002355	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
497965002356	oligomer interface [polypeptide binding]; other site
497965002357	metal binding site [ion binding]; metal-binding site
497965002358	metal binding site [ion binding]; metal-binding site
497965002359	Cl binding site [ion binding]; other site
497965002360	aspartate ring; other site
497965002361	basic sphincter; other site
497965002362	putative hydrophobic gate; other site
497965002363	periplasmic entrance; other site
497965002364	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
497965002365	dimer interface [polypeptide binding]; other site
497965002366	catalytic triad [active]
497965002367	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
497965002368	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
497965002369	substrate binding site [chemical binding]; other site
497965002370	active site
497965002371	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
497965002372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965002373	NAD(P) binding site [chemical binding]; other site
497965002374	active site
497965002375	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965002376	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
497965002377	putative ADP-binding pocket [chemical binding]; other site
497965002378	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
497965002379	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
497965002380	RRXRR protein; Region: RRXRR; pfam14239
497965002381	Protein of unknown function (DUF760); Region: DUF760; pfam05542
497965002382	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
497965002383	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
497965002384	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
497965002385	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
497965002386	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
497965002387	Ankyrin repeat; Region: Ank; pfam00023
497965002388	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
497965002389	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
497965002390	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
497965002391	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
497965002392	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
497965002393	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
497965002394	Protein of unknown function (DUF952); Region: DUF952; pfam06108
497965002395	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
497965002396	haemagglutination activity domain; Region: Haemagg_act; pfam05860
497965002397	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
497965002398	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
497965002399	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
497965002400	Surface antigen; Region: Bac_surface_Ag; pfam01103
497965002401	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
497965002402	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
497965002403	Ligand Binding Site [chemical binding]; other site
497965002404	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
497965002405	RecX family; Region: RecX; cl00936
497965002406	Domain of unknown function (DUF814); Region: DUF814; pfam05670
497965002407	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
497965002408	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
497965002409	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
497965002410	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
497965002411	Domain of unknown function DUF21; Region: DUF21; pfam01595
497965002412	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
497965002413	Transporter associated domain; Region: CorC_HlyC; smart01091
497965002414	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
497965002415	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
497965002416	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
497965002417	active site
497965002418	catalytic triad [active]
497965002419	oxyanion hole [active]
497965002420	Domain of unknown function DUF21; Region: DUF21; pfam01595
497965002421	FOG: CBS domain [General function prediction only]; Region: COG0517
497965002422	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
497965002423	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
497965002424	Part of AAA domain; Region: AAA_19; pfam13245
497965002425	Family description; Region: UvrD_C_2; pfam13538
497965002426	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
497965002427	putative active site [active]
497965002428	putative metal-binding site [ion binding]; other site
497965002429	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
497965002430	trimer interface [polypeptide binding]; other site
497965002431	active site
497965002432	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
497965002433	dimerization interface [polypeptide binding]; other site
497965002434	active site
497965002435	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
497965002436	thymidylate kinase; Region: DTMP_kinase; TIGR00041
497965002437	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
497965002438	TMP-binding site; other site
497965002439	ATP-binding site [chemical binding]; other site
497965002440	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965002441	putative active site [active]
497965002442	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
497965002443	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497965002444	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
497965002445	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
497965002446	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497965002447	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965002448	homodimer interface [polypeptide binding]; other site
497965002449	catalytic residue [active]
497965002450	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
497965002451	IHF dimer interface [polypeptide binding]; other site
497965002452	IHF - DNA interface [nucleotide binding]; other site
497965002453	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
497965002454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965002455	dimer interface [polypeptide binding]; other site
497965002456	conserved gate region; other site
497965002457	putative PBP binding loops; other site
497965002458	ABC-ATPase subunit interface; other site
497965002459	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
497965002460	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965002461	putative active site [active]
497965002462	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
497965002463	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497965002464	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
497965002465	Walker A/P-loop; other site
497965002466	ATP binding site [chemical binding]; other site
497965002467	Q-loop/lid; other site
497965002468	ABC transporter signature motif; other site
497965002469	Walker B; other site
497965002470	D-loop; other site
497965002471	H-loop/switch region; other site
497965002472	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
497965002473	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965002474	active site
497965002475	ATP binding site [chemical binding]; other site
497965002476	substrate binding site [chemical binding]; other site
497965002477	activation loop (A-loop); other site
497965002478	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
497965002479	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497965002480	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
497965002481	dimer interface [polypeptide binding]; other site
497965002482	active site
497965002483	metal binding site [ion binding]; metal-binding site
497965002484	glutathione binding site [chemical binding]; other site
497965002485	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
497965002486	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
497965002487	active site clefts [active]
497965002488	zinc binding site [ion binding]; other site
497965002489	dimer interface [polypeptide binding]; other site
497965002490	Domain of unknown function DUF21; Region: DUF21; pfam01595
497965002491	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
497965002492	active site
497965002493	putative DNA-binding cleft [nucleotide binding]; other site
497965002494	dimer interface [polypeptide binding]; other site
497965002495	Virulence-associated protein E; Region: VirE; pfam05272
497965002496	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
497965002497	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497965002498	catalytic loop [active]
497965002499	iron binding site [ion binding]; other site
497965002500	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
497965002501	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
497965002502	active site
497965002503	dimerization interface [polypeptide binding]; other site
497965002504	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
497965002505	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965002506	HSP70 interaction site [polypeptide binding]; other site
497965002507	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002508	TPR repeat; Region: TPR_11; pfam13414
497965002509	binding surface
497965002510	TPR motif; other site
497965002511	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
497965002512	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
497965002513	dimer interface [polypeptide binding]; other site
497965002514	motif 1; other site
497965002515	active site
497965002516	motif 2; other site
497965002517	motif 3; other site
497965002518	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
497965002519	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497965002520	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965002521	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
497965002522	active site
497965002523	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965002524	GAF domain; Region: GAF; pfam01590
497965002525	Phytochrome region; Region: PHY; pfam00360
497965002526	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965002527	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965002528	metal binding site [ion binding]; metal-binding site
497965002529	active site
497965002530	I-site; other site
497965002531	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965002532	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965002533	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965002534	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965002535	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965002536	metal binding site [ion binding]; metal-binding site
497965002537	active site
497965002538	I-site; other site
497965002539	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965002540	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965002541	DNA binding residues [nucleotide binding]
497965002542	dimerization interface [polypeptide binding]; other site
497965002543	Permease; Region: Permease; cl00510
497965002544	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
497965002545	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
497965002546	mce related protein; Region: MCE; pfam02470
497965002547	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
497965002548	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
497965002549	Walker A/P-loop; other site
497965002550	ATP binding site [chemical binding]; other site
497965002551	Q-loop/lid; other site
497965002552	ABC transporter signature motif; other site
497965002553	Walker B; other site
497965002554	D-loop; other site
497965002555	H-loop/switch region; other site
497965002556	Acylphosphatase; Region: Acylphosphatase; cl00551
497965002557	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
497965002558	Cysteine-rich domain; Region: CCG; pfam02754
497965002559	Cysteine-rich domain; Region: CCG; pfam02754
497965002560	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
497965002561	ligand binding surface [chemical binding]; other site
497965002562	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
497965002563	ligand binding surface [chemical binding]; other site
497965002564	acyl carrier protein; Provisional; Region: acpP; PRK00982
497965002565	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
497965002566	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
497965002567	dimer interface [polypeptide binding]; other site
497965002568	active site
497965002569	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
497965002570	transketolase; Region: PLN02790
497965002571	TPP-binding site [chemical binding]; other site
497965002572	dimer interface [polypeptide binding]; other site
497965002573	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
497965002574	PYR/PP interface [polypeptide binding]; other site
497965002575	dimer interface [polypeptide binding]; other site
497965002576	TPP binding site [chemical binding]; other site
497965002577	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
497965002578	WD domain, G-beta repeat; Region: WD40; pfam00400
497965002579	PQQ-like domain; Region: PQQ_2; pfam13360
497965002580	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965002581	structural tetrad; other site
497965002582	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
497965002583	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965002584	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965002585	structural tetrad; other site
497965002586	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965002587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965002588	active site
497965002589	phosphorylation site [posttranslational modification]
497965002590	intermolecular recognition site; other site
497965002591	dimerization interface [polypeptide binding]; other site
497965002592	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
497965002593	Domain of unknown function DUF39; Region: DUF39; pfam01837
497965002594	Dynamin family; Region: Dynamin_N; pfam00350
497965002595	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
497965002596	G1 box; other site
497965002597	GTP/Mg2+ binding site [chemical binding]; other site
497965002598	Switch I region; other site
497965002599	G2 box; other site
497965002600	Switch II region; other site
497965002601	G3 box; other site
497965002602	G4 box; other site
497965002603	G5 box; other site
497965002604	Domain of unknown function (DUF697); Region: DUF697; pfam05128
497965002605	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002606	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002607	binding surface
497965002608	TPR motif; other site
497965002609	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002610	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002612	binding surface
497965002613	TPR motif; other site
497965002614	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002615	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002616	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002617	binding surface
497965002618	TPR motif; other site
497965002619	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002620	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002621	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002622	binding surface
497965002623	TPR motif; other site
497965002624	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002625	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002626	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002627	binding surface
497965002628	TPR motif; other site
497965002629	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002630	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002631	binding surface
497965002632	TPR motif; other site
497965002633	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002634	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965002635	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002636	binding surface
497965002637	TPR motif; other site
497965002638	CHAT domain; Region: CHAT; pfam12770
497965002639	Uncharacterized conserved protein [Function unknown]; Region: COG2442
497965002640	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
497965002641	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
497965002642	hinge; other site
497965002643	active site
497965002644	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
497965002645	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
497965002646	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
497965002647	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
497965002648	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
497965002649	AMIN domain; Region: AMIN; pfam11741
497965002650	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
497965002651	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
497965002652	active site
497965002653	metal binding site [ion binding]; metal-binding site
497965002654	glutamate racemase; Provisional; Region: PRK00865
497965002655	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
497965002656	dimerization interface [polypeptide binding]; other site
497965002657	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
497965002658	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965002659	putative substrate translocation pore; other site
497965002660	hypothetical protein; Validated; Region: PRK07411
497965002661	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
497965002662	ATP binding site [chemical binding]; other site
497965002663	substrate interface [chemical binding]; other site
497965002664	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
497965002665	active site residue [active]
497965002666	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
497965002667	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497965002668	putative metal binding site [ion binding]; other site
497965002669	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
497965002670	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
497965002671	short chain dehydrogenase; Provisional; Region: PRK12367
497965002672	NAD(P) binding site [chemical binding]; other site
497965002673	active site
497965002674	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965002675	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
497965002676	DXD motif; other site
497965002677	Predicted transcriptional regulators [Transcription]; Region: COG1695
497965002678	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
497965002679	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
497965002680	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
497965002681	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
497965002682	active site
497965002683	catalytic site [active]
497965002684	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965002685	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965002686	active site
497965002687	phosphorylation site [posttranslational modification]
497965002688	intermolecular recognition site; other site
497965002689	dimerization interface [polypeptide binding]; other site
497965002690	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965002691	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965002692	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965002693	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965002694	putative active site [active]
497965002695	heme pocket [chemical binding]; other site
497965002696	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965002697	putative active site [active]
497965002698	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
497965002699	heme pocket [chemical binding]; other site
497965002700	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965002701	dimer interface [polypeptide binding]; other site
497965002702	phosphorylation site [posttranslational modification]
497965002703	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965002704	ATP binding site [chemical binding]; other site
497965002705	Mg2+ binding site [ion binding]; other site
497965002706	G-X-G motif; other site
497965002707	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965002708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965002709	active site
497965002710	phosphorylation site [posttranslational modification]
497965002711	intermolecular recognition site; other site
497965002712	dimerization interface [polypeptide binding]; other site
497965002713	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
497965002714	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
497965002715	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
497965002716	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497965002717	Walker A/P-loop; other site
497965002718	ATP binding site [chemical binding]; other site
497965002719	Q-loop/lid; other site
497965002720	ABC transporter signature motif; other site
497965002721	Walker B; other site
497965002722	D-loop; other site
497965002723	H-loop/switch region; other site
497965002724	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497965002725	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965002726	dimer interface [polypeptide binding]; other site
497965002727	conserved gate region; other site
497965002728	putative PBP binding loops; other site
497965002729	ABC-ATPase subunit interface; other site
497965002730	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
497965002731	active site clefts [active]
497965002732	zinc binding site [ion binding]; other site
497965002733	dimer interface [polypeptide binding]; other site
497965002734	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
497965002735	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
497965002736	active site
497965002737	dimer interface [polypeptide binding]; other site
497965002738	non-prolyl cis peptide bond; other site
497965002739	insertion regions; other site
497965002740	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
497965002741	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497965002742	substrate binding pocket [chemical binding]; other site
497965002743	membrane-bound complex binding site; other site
497965002744	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
497965002745	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497965002746	substrate binding pocket [chemical binding]; other site
497965002747	membrane-bound complex binding site; other site
497965002748	hinge residues; other site
497965002749	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
497965002750	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14265
497965002751	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
497965002752	Walker A/P-loop; other site
497965002753	ATP binding site [chemical binding]; other site
497965002754	Q-loop/lid; other site
497965002755	ABC transporter signature motif; other site
497965002756	Walker B; other site
497965002757	D-loop; other site
497965002758	H-loop/switch region; other site
497965002759	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
497965002760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965002761	dimer interface [polypeptide binding]; other site
497965002762	conserved gate region; other site
497965002763	putative PBP binding loops; other site
497965002764	ABC-ATPase subunit interface; other site
497965002765	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
497965002766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965002767	dimer interface [polypeptide binding]; other site
497965002768	conserved gate region; other site
497965002769	ABC-ATPase subunit interface; other site
497965002770	PBP superfamily domain; Region: PBP_like_2; cl17296
497965002771	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
497965002772	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
497965002773	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
497965002774	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497965002775	putative binding surface; other site
497965002776	active site
497965002777	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497965002778	putative binding surface; other site
497965002779	active site
497965002780	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497965002781	putative binding surface; other site
497965002782	active site
497965002783	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
497965002784	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
497965002785	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965002786	ATP binding site [chemical binding]; other site
497965002787	Mg2+ binding site [ion binding]; other site
497965002788	G-X-G motif; other site
497965002789	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
497965002790	Response regulator receiver domain; Region: Response_reg; pfam00072
497965002791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965002792	active site
497965002793	phosphorylation site [posttranslational modification]
497965002794	intermolecular recognition site; other site
497965002795	dimerization interface [polypeptide binding]; other site
497965002796	HAMP domain; Region: HAMP; pfam00672
497965002797	dimerization interface [polypeptide binding]; other site
497965002798	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965002799	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965002800	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
497965002801	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
497965002802	dimer interface [polypeptide binding]; other site
497965002803	putative CheW interface [polypeptide binding]; other site
497965002804	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965002805	dimerization interface [polypeptide binding]; other site
497965002806	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965002807	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965002808	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965002809	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965002810	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
497965002811	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
497965002812	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
497965002813	dimer interface [polypeptide binding]; other site
497965002814	putative CheW interface [polypeptide binding]; other site
497965002815	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965002816	Two component signalling adaptor domain; Region: CheW; smart00260
497965002817	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965002818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965002819	active site
497965002820	phosphorylation site [posttranslational modification]
497965002821	intermolecular recognition site; other site
497965002822	dimerization interface [polypeptide binding]; other site
497965002823	Response regulator receiver domain; Region: Response_reg; pfam00072
497965002824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965002825	active site
497965002826	phosphorylation site [posttranslational modification]
497965002827	intermolecular recognition site; other site
497965002828	dimerization interface [polypeptide binding]; other site
497965002829	CheW-like domain; Region: CheW; pfam01584
497965002830	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
497965002831	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497965002832	putative binding surface; other site
497965002833	active site
497965002834	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
497965002835	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
497965002836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965002837	ATP binding site [chemical binding]; other site
497965002838	Mg2+ binding site [ion binding]; other site
497965002839	G-X-G motif; other site
497965002840	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
497965002841	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965002842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965002843	active site
497965002844	phosphorylation site [posttranslational modification]
497965002845	intermolecular recognition site; other site
497965002846	dimerization interface [polypeptide binding]; other site
497965002847	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
497965002848	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497965002849	catalytic loop [active]
497965002850	iron binding site [ion binding]; other site
497965002851	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965002852	dimerization interface [polypeptide binding]; other site
497965002853	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
497965002854	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
497965002855	dimer interface [polypeptide binding]; other site
497965002856	putative CheW interface [polypeptide binding]; other site
497965002857	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
497965002858	Response regulator receiver domain; Region: Response_reg; pfam00072
497965002859	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965002860	active site
497965002861	phosphorylation site [posttranslational modification]
497965002862	intermolecular recognition site; other site
497965002863	dimerization interface [polypeptide binding]; other site
497965002864	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
497965002865	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
497965002866	Walker A/P-loop; other site
497965002867	ATP binding site [chemical binding]; other site
497965002868	Q-loop/lid; other site
497965002869	ABC transporter signature motif; other site
497965002870	Walker B; other site
497965002871	D-loop; other site
497965002872	H-loop/switch region; other site
497965002873	plastocyanin; Provisional; Region: PRK02710
497965002874	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
497965002875	exonuclease SbcC; Region: sbcc; TIGR00618
497965002876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965002877	Walker A/P-loop; other site
497965002878	ATP binding site [chemical binding]; other site
497965002879	Q-loop/lid; other site
497965002880	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965002881	ABC transporter signature motif; other site
497965002882	Walker B; other site
497965002883	D-loop; other site
497965002884	H-loop/switch region; other site
497965002885	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
497965002886	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
497965002887	substrate binding site [chemical binding]; other site
497965002888	ligand binding site [chemical binding]; other site
497965002889	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
497965002890	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
497965002891	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965002892	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
497965002893	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
497965002894	catalytic residue [active]
497965002895	putative FPP diphosphate  binding site; other site
497965002896	putative FPP binding hydrophobic cleft; other site
497965002897	dimer interface [polypeptide binding]; other site
497965002898	putative IPP diphosphate binding site; other site
497965002899	TIGR00159 family protein; Region: TIGR00159
497965002900	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
497965002901	diaminopimelate decarboxylase; Region: lysA; TIGR01048
497965002902	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
497965002903	active site
497965002904	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
497965002905	substrate binding site [chemical binding]; other site
497965002906	catalytic residues [active]
497965002907	dimer interface [polypeptide binding]; other site
497965002908	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
497965002909	4Fe-4S binding domain; Region: Fer4; pfam00037
497965002910	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
497965002911	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
497965002912	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
497965002913	5S rRNA interface [nucleotide binding]; other site
497965002914	CTC domain interface [polypeptide binding]; other site
497965002915	L16 interface [polypeptide binding]; other site
497965002916	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
497965002917	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
497965002918	GDP-binding site [chemical binding]; other site
497965002919	ACT binding site; other site
497965002920	IMP binding site; other site
497965002921	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965002922	putative active site [active]
497965002923	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
497965002924	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
497965002925	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965002926	binding surface
497965002927	TPR motif; other site
497965002928	Tetratricopeptide repeat; Region: TPR_16; pfam13432
497965002929	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
497965002930	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
497965002931	CVNH domain; Region: CVNH; pfam08881
497965002932	signal recognition particle protein; Provisional; Region: PRK10867
497965002933	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
497965002934	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
497965002935	P loop; other site
497965002936	GTP binding site [chemical binding]; other site
497965002937	Signal peptide binding domain; Region: SRP_SPB; pfam02978
497965002938	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
497965002939	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
497965002940	putative active site [active]
497965002941	catalytic site [active]
497965002942	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
497965002943	putative active site [active]
497965002944	catalytic site [active]
497965002945	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
497965002946	Helix-hairpin-helix motif; Region: HHH; pfam00633
497965002947	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
497965002948	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965002949	S-adenosylmethionine binding site [chemical binding]; other site
497965002950	Uncharacterized conserved protein [Function unknown]; Region: COG2968
497965002951	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
497965002952	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
497965002953	TIR domain; Region: TIR_2; pfam13676
497965002954	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
497965002955	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
497965002956	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965002957	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965002958	phosphopeptide binding site; other site
497965002959	Protease prsW family; Region: PrsW-protease; pfam13367
497965002960	C factor cell-cell signaling protein; Provisional; Region: PRK09009
497965002961	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
497965002962	NADP binding site [chemical binding]; other site
497965002963	homodimer interface [polypeptide binding]; other site
497965002964	active site
497965002965	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
497965002966	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965002967	GAF domain; Region: GAF; pfam01590
497965002968	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965002969	dimer interface [polypeptide binding]; other site
497965002970	phosphorylation site [posttranslational modification]
497965002971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965002972	ATP binding site [chemical binding]; other site
497965002973	Mg2+ binding site [ion binding]; other site
497965002974	G-X-G motif; other site
497965002975	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497965002976	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965002977	dimer interface [polypeptide binding]; other site
497965002978	conserved gate region; other site
497965002979	putative PBP binding loops; other site
497965002980	ABC-ATPase subunit interface; other site
497965002981	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
497965002982	NMT1-like family; Region: NMT1_2; pfam13379
497965002983	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497965002984	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
497965002985	Walker A/P-loop; other site
497965002986	ATP binding site [chemical binding]; other site
497965002987	Q-loop/lid; other site
497965002988	ABC transporter signature motif; other site
497965002989	Walker B; other site
497965002990	D-loop; other site
497965002991	H-loop/switch region; other site
497965002992	Chorismate lyase; Region: Chor_lyase; cl01230
497965002993	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
497965002994	proposed catalytic triad [active]
497965002995	active site nucleophile [active]
497965002996	4-alpha-glucanotransferase; Provisional; Region: PRK14508
497965002997	Uncharacterized conserved protein [Function unknown]; Region: COG2128
497965002998	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
497965002999	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
497965003000	putative active site [active]
497965003001	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cd00562
497965003002	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
497965003003	trimer interface [polypeptide binding]; other site
497965003004	active site
497965003005	substrate binding site [chemical binding]; other site
497965003006	CoA binding site [chemical binding]; other site
497965003007	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
497965003008	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
497965003009	Probable Catalytic site; other site
497965003010	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
497965003011	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
497965003012	homodimer interface [polypeptide binding]; other site
497965003013	substrate-cofactor binding pocket; other site
497965003014	catalytic residue [active]
497965003015	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
497965003016	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
497965003017	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
497965003018	Zn binding site [ion binding]; other site
497965003019	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
497965003020	protein binding site [polypeptide binding]; other site
497965003021	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965003022	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965003023	ligand binding site [chemical binding]; other site
497965003024	flexible hinge region; other site
497965003025	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497965003026	active site
497965003027	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
497965003028	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
497965003029	hypothetical protein; Reviewed; Region: PRK09588
497965003030	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965003031	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
497965003032	Walker A motif; other site
497965003033	ATP binding site [chemical binding]; other site
497965003034	Walker B motif; other site
497965003035	arginine finger; other site
497965003036	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
497965003037	metal ion-dependent adhesion site (MIDAS); other site
497965003038	light-harvesting-like protein 3; Provisional; Region: PLN00014
497965003039	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497965003040	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965003041	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
497965003042	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
497965003043	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
497965003044	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
497965003045	Walker A/P-loop; other site
497965003046	ATP binding site [chemical binding]; other site
497965003047	Q-loop/lid; other site
497965003048	ABC transporter signature motif; other site
497965003049	Walker B; other site
497965003050	D-loop; other site
497965003051	H-loop/switch region; other site
497965003052	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
497965003053	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
497965003054	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
497965003055	B12 binding site [chemical binding]; other site
497965003056	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965003057	FeS/SAM binding site; other site
497965003058	arginine decarboxylase; Provisional; Region: PRK05354
497965003059	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
497965003060	dimer interface [polypeptide binding]; other site
497965003061	active site
497965003062	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
497965003063	catalytic residues [active]
497965003064	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
497965003065	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
497965003066	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
497965003067	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
497965003068	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
497965003069	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
497965003070	ribosomal protein L32; Validated; Region: rpl32; CHL00152
497965003071	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
497965003072	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
497965003073	Moco binding site; other site
497965003074	metal coordination site [ion binding]; other site
497965003075	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
497965003076	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
497965003077	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
497965003078	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
497965003079	non-specific DNA binding site [nucleotide binding]; other site
497965003080	salt bridge; other site
497965003081	sequence-specific DNA binding site [nucleotide binding]; other site
497965003082	AAA ATPase domain; Region: AAA_16; pfam13191
497965003083	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
497965003084	AAA domain; Region: AAA_22; pfam13401
497965003085	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
497965003086	active site lid residues [active]
497965003087	substrate binding pocket [chemical binding]; other site
497965003088	catalytic residues [active]
497965003089	substrate-Mg2+ binding site; other site
497965003090	aspartate-rich region 1; other site
497965003091	aspartate-rich region 2; other site
497965003092	phytoene desaturase; Region: phytoene_desat; TIGR02731
497965003093	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965003094	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
497965003095	lipoyl attachment site [posttranslational modification]; other site
497965003096	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
497965003097	rRNA interaction site [nucleotide binding]; other site
497965003098	S8 interaction site; other site
497965003099	putative laminin-1 binding site; other site
497965003100	elongation factor Ts; Reviewed; Region: tsf; PRK12332
497965003101	UBA/TS-N domain; Region: UBA; pfam00627
497965003102	Elongation factor TS; Region: EF_TS; pfam00889
497965003103	Protein of unknown function (DUF2866); Region: DUF2866; pfam11065
497965003104	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
497965003105	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
497965003106	generic binding surface II; other site
497965003107	ssDNA binding site; other site
497965003108	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965003109	ATP binding site [chemical binding]; other site
497965003110	putative Mg++ binding site [ion binding]; other site
497965003111	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965003112	nucleotide binding region [chemical binding]; other site
497965003113	ATP-binding site [chemical binding]; other site
497965003114	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
497965003115	CoA binding domain; Region: CoA_binding_2; pfam13380
497965003116	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
497965003117	CoA-ligase; Region: Ligase_CoA; pfam00549
497965003118	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
497965003119	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
497965003120	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
497965003121	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
497965003122	DNA methylase; Region: N6_N4_Mtase; pfam01555
497965003123	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
497965003124	Domain of unknown function DUF87; Region: DUF87; pfam01935
497965003125	HerA helicase [Replication, recombination, and repair]; Region: COG0433
497965003126	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
497965003127	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
497965003128	catalytic triad [active]
497965003129	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
497965003130	Predicted transcriptional regulator [Transcription]; Region: COG3682
497965003131	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
497965003132	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
497965003133	hexamer interface [polypeptide binding]; other site
497965003134	ligand binding site [chemical binding]; other site
497965003135	putative active site [active]
497965003136	NAD(P) binding site [chemical binding]; other site
497965003137	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
497965003138	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
497965003139	putative DNA binding helix; other site
497965003140	metal binding site 1 [ion binding]; metal-binding site
497965003141	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
497965003142	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
497965003143	active site
497965003144	catalytic tetrad [active]
497965003145	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
497965003146	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
497965003147	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
497965003148	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
497965003149	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
497965003150	DNA methylase; Region: N6_N4_Mtase; pfam01555
497965003151	photosystem II 47 kDa protein; Region: psbB; CHL00062
497965003152	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
497965003153	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
497965003154	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
497965003155	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
497965003156	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965003157	ATP binding site [chemical binding]; other site
497965003158	Mg2+ binding site [ion binding]; other site
497965003159	G-X-G motif; other site
497965003160	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
497965003161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
497965003162	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
497965003163	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
497965003164	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965003165	ATP binding site [chemical binding]; other site
497965003166	Mg2+ binding site [ion binding]; other site
497965003167	G-X-G motif; other site
497965003168	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965003169	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965003170	dimer interface [polypeptide binding]; other site
497965003171	phosphorylation site [posttranslational modification]
497965003172	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965003173	ATP binding site [chemical binding]; other site
497965003174	Mg2+ binding site [ion binding]; other site
497965003175	G-X-G motif; other site
497965003176	Response regulator receiver domain; Region: Response_reg; pfam00072
497965003177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965003178	active site
497965003179	phosphorylation site [posttranslational modification]
497965003180	intermolecular recognition site; other site
497965003181	dimerization interface [polypeptide binding]; other site
497965003182	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965003183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965003184	active site
497965003185	phosphorylation site [posttranslational modification]
497965003186	intermolecular recognition site; other site
497965003187	Response regulator receiver domain; Region: Response_reg; pfam00072
497965003188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965003189	active site
497965003190	phosphorylation site [posttranslational modification]
497965003191	intermolecular recognition site; other site
497965003192	dimerization interface [polypeptide binding]; other site
497965003193	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003194	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965003195	putative active site [active]
497965003196	heme pocket [chemical binding]; other site
497965003197	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965003198	dimer interface [polypeptide binding]; other site
497965003199	phosphorylation site [posttranslational modification]
497965003200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965003201	ATP binding site [chemical binding]; other site
497965003202	Mg2+ binding site [ion binding]; other site
497965003203	G-X-G motif; other site
497965003204	Response regulator receiver domain; Region: Response_reg; pfam00072
497965003205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965003206	active site
497965003207	phosphorylation site [posttranslational modification]
497965003208	intermolecular recognition site; other site
497965003209	dimerization interface [polypeptide binding]; other site
497965003210	EamA-like transporter family; Region: EamA; pfam00892
497965003211	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
497965003212	EamA-like transporter family; Region: EamA; pfam00892
497965003213	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
497965003214	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
497965003215	ATP cone domain; Region: ATP-cone; pfam03477
497965003216	30S ribosomal protein S1; Reviewed; Region: PRK07400
497965003217	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
497965003218	RNA binding site [nucleotide binding]; other site
497965003219	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
497965003220	RNA binding site [nucleotide binding]; other site
497965003221	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
497965003222	RNA binding site [nucleotide binding]; other site
497965003223	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
497965003224	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965003225	S-adenosylmethionine synthetase; Validated; Region: PRK05250
497965003226	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
497965003227	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
497965003228	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
497965003229	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
497965003230	Uncharacterized conserved protein [Function unknown]; Region: COG2308
497965003231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
497965003232	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
497965003233	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
497965003234	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
497965003235	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
497965003236	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965003237	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
497965003238	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497965003239	catalytic loop [active]
497965003240	iron binding site [ion binding]; other site
497965003241	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497965003242	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965003243	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
497965003244	Domain of unknown function DUF20; Region: UPF0118; pfam01594
497965003245	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497965003246	Ligand Binding Site [chemical binding]; other site
497965003247	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
497965003248	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
497965003249	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965003250	catalytic residue [active]
497965003251	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
497965003252	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
497965003253	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
497965003254	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
497965003255	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
497965003256	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
497965003257	catalytic site [active]
497965003258	putative active site [active]
497965003259	putative substrate binding site [chemical binding]; other site
497965003260	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
497965003261	active site
497965003262	ribulose/triose binding site [chemical binding]; other site
497965003263	phosphate binding site [ion binding]; other site
497965003264	substrate (anthranilate) binding pocket [chemical binding]; other site
497965003265	product (indole) binding pocket [chemical binding]; other site
497965003266	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
497965003267	homodimer interface [polypeptide binding]; other site
497965003268	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965003269	catalytic residue [active]
497965003270	TIR domain; Region: TIR_2; pfam13676
497965003271	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965003272	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965003273	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965003274	binding surface
497965003275	TPR motif; other site
497965003276	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965003277	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965003278	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965003279	binding surface
497965003280	TPR motif; other site
497965003281	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965003282	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965003283	binding surface
497965003284	TPR motif; other site
497965003285	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965003286	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965003287	Tetratricopeptide repeat; Region: TPR_10; pfam13374
497965003288	DNA polymerase III subunit delta; Validated; Region: PRK07452
497965003289	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
497965003290	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
497965003291	Uncharacterized conserved protein [Function unknown]; Region: COG5464
497965003292	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965003293	putative active site [active]
497965003294	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
497965003295	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
497965003296	[4Fe-4S] binding site [ion binding]; other site
497965003297	molybdopterin cofactor binding site; other site
497965003298	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
497965003299	molybdopterin cofactor binding site; other site
497965003300	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965003301	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
497965003302	Putative restriction endonuclease; Region: Uma2; pfam05685
497965003303	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965003304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965003305	active site
497965003306	phosphorylation site [posttranslational modification]
497965003307	intermolecular recognition site; other site
497965003308	dimerization interface [polypeptide binding]; other site
497965003309	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965003310	DNA binding site [nucleotide binding]
497965003311	Ion channel; Region: Ion_trans_2; pfam07885
497965003312	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
497965003313	TrkA-N domain; Region: TrkA_N; pfam02254
497965003314	TrkA-C domain; Region: TrkA_C; pfam02080
497965003315	acetylornithine aminotransferase; Provisional; Region: PRK02627
497965003316	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
497965003317	inhibitor-cofactor binding pocket; inhibition site
497965003318	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965003319	catalytic residue [active]
497965003320	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
497965003321	ribosomal protein L21; Region: rpl21; CHL00075
497965003322	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
497965003323	ATP-grasp domain; Region: ATP-grasp; pfam02222
497965003324	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497965003325	Peptidase family M23; Region: Peptidase_M23; pfam01551
497965003326	enoyl-CoA hydratase; Provisional; Region: PRK09076
497965003327	large tegument protein UL36; Provisional; Region: PHA03247
497965003328	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
497965003329	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965003330	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965003331	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965003332	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965003333	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
497965003334	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
497965003335	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
497965003336	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
497965003337	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
497965003338	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
497965003339	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965003340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
497965003341	dimer interface [polypeptide binding]; other site
497965003342	phosphorylation site [posttranslational modification]
497965003343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965003344	ATP binding site [chemical binding]; other site
497965003345	Mg2+ binding site [ion binding]; other site
497965003346	G-X-G motif; other site
497965003347	putative acyltransferase; Provisional; Region: PRK05790
497965003348	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
497965003349	dimer interface [polypeptide binding]; other site
497965003350	active site
497965003351	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
497965003352	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965003353	NAD(P) binding site [chemical binding]; other site
497965003354	active site
497965003355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965003356	Probable transposase; Region: OrfB_IS605; pfam01385
497965003357	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914
497965003358	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
497965003359	Phosphotransferase enzyme family; Region: APH; pfam01636
497965003360	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
497965003361	active site
497965003362	ATP binding site [chemical binding]; other site
497965003363	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
497965003364	substrate binding site [chemical binding]; other site
497965003365	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
497965003366	substrate binding site [chemical binding]; other site
497965003367	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
497965003368	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
497965003369	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
497965003370	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
497965003371	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965003372	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965003373	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965003374	ligand binding site [chemical binding]; other site
497965003375	flexible hinge region; other site
497965003376	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
497965003377	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
497965003378	putative active site [active]
497965003379	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497965003380	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
497965003381	Walker A/P-loop; other site
497965003382	ATP binding site [chemical binding]; other site
497965003383	Q-loop/lid; other site
497965003384	ABC transporter signature motif; other site
497965003385	Walker B; other site
497965003386	D-loop; other site
497965003387	H-loop/switch region; other site
497965003388	Homeodomain-like domain; Region: HTH_23; pfam13384
497965003389	Winged helix-turn helix; Region: HTH_29; pfam13551
497965003390	Winged helix-turn helix; Region: HTH_33; pfam13592
497965003391	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
497965003392	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
497965003393	Cl- selectivity filter; other site
497965003394	Cl- binding residues [ion binding]; other site
497965003395	pore gating glutamate residue; other site
497965003396	dimer interface [polypeptide binding]; other site
497965003397	H+/Cl- coupling transport residue; other site
497965003398	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965003399	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
497965003400	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
497965003401	putative acyl-acceptor binding pocket; other site
497965003402	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
497965003403	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
497965003404	active site
497965003405	HIGH motif; other site
497965003406	KMSKS motif; other site
497965003407	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
497965003408	anticodon binding site; other site
497965003409	tRNA binding surface [nucleotide binding]; other site
497965003410	Uncharacterized conserved protein [Function unknown]; Region: COG1432
497965003411	LabA_like proteins; Region: LabA; cd10911
497965003412	putative metal binding site [ion binding]; other site
497965003413	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
497965003414	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
497965003415	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
497965003416	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965003417	structural tetrad; other site
497965003418	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965003419	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965003420	structural tetrad; other site
497965003421	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965003422	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965003423	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
497965003424	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
497965003425	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
497965003426	photosystem II reaction center protein K; Provisional; Region: psbK; PRK02553
497965003427	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
497965003428	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
497965003429	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
497965003430	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
497965003431	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
497965003432	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
497965003433	putative ligand binding site [chemical binding]; other site
497965003434	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
497965003435	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
497965003436	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
497965003437	TM-ABC transporter signature motif; other site
497965003438	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
497965003439	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
497965003440	TM-ABC transporter signature motif; other site
497965003441	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
497965003442	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
497965003443	Walker A/P-loop; other site
497965003444	ATP binding site [chemical binding]; other site
497965003445	Q-loop/lid; other site
497965003446	ABC transporter signature motif; other site
497965003447	Walker B; other site
497965003448	D-loop; other site
497965003449	H-loop/switch region; other site
497965003450	tellurium resistance terB-like protein; Region: terB_like; cd07177
497965003451	metal binding site [ion binding]; metal-binding site
497965003452	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
497965003453	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
497965003454	Walker A/P-loop; other site
497965003455	ATP binding site [chemical binding]; other site
497965003456	Q-loop/lid; other site
497965003457	ABC transporter signature motif; other site
497965003458	Walker B; other site
497965003459	D-loop; other site
497965003460	H-loop/switch region; other site
497965003461	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
497965003462	active site
497965003463	multimer interface [polypeptide binding]; other site
497965003464	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
497965003465	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
497965003466	Protein of unknown function (DUF512); Region: DUF512; pfam04459
497965003467	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
497965003468	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
497965003469	ribonuclease E; Reviewed; Region: rne; PRK10811
497965003470	Predicted metal-binding protein [General function prediction only]; Region: COG3019
497965003471	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003472	PAS fold; Region: PAS_3; pfam08447
497965003473	putative active site [active]
497965003474	heme pocket [chemical binding]; other site
497965003475	PAS fold; Region: PAS_4; pfam08448
497965003476	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003477	putative active site [active]
497965003478	heme pocket [chemical binding]; other site
497965003479	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965003480	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965003481	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965003482	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003483	putative active site [active]
497965003484	heme pocket [chemical binding]; other site
497965003485	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965003486	dimer interface [polypeptide binding]; other site
497965003487	phosphorylation site [posttranslational modification]
497965003488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965003489	ATP binding site [chemical binding]; other site
497965003490	Mg2+ binding site [ion binding]; other site
497965003491	G-X-G motif; other site
497965003492	Response regulator receiver domain; Region: Response_reg; pfam00072
497965003493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965003494	active site
497965003495	phosphorylation site [posttranslational modification]
497965003496	intermolecular recognition site; other site
497965003497	dimerization interface [polypeptide binding]; other site
497965003498	homoserine kinase; Provisional; Region: PRK01212
497965003499	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
497965003500	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
497965003501	Moco binding site; other site
497965003502	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
497965003503	metal coordination site [ion binding]; other site
497965003504	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
497965003505	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
497965003506	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
497965003507	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
497965003508	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
497965003509	catalytic residues [active]
497965003510	hypothetical protein; Validated; Region: PRK00068
497965003511	methionine sulfoxide reductase A; Provisional; Region: PRK13014
497965003512	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
497965003513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965003514	S-adenosylmethionine binding site [chemical binding]; other site
497965003515	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
497965003516	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
497965003517	active site
497965003518	metal binding site [ion binding]; metal-binding site
497965003519	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
497965003520	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
497965003521	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965003522	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965003523	active site
497965003524	ATP binding site [chemical binding]; other site
497965003525	substrate binding site [chemical binding]; other site
497965003526	activation loop (A-loop); other site
497965003527	AAA ATPase domain; Region: AAA_16; pfam13191
497965003528	Predicted ATPase [General function prediction only]; Region: COG3899
497965003529	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965003530	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965003531	PAS fold; Region: PAS_4; pfam08448
497965003532	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003533	putative active site [active]
497965003534	heme pocket [chemical binding]; other site
497965003535	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003536	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965003537	putative active site [active]
497965003538	heme pocket [chemical binding]; other site
497965003539	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003540	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965003541	putative active site [active]
497965003542	heme pocket [chemical binding]; other site
497965003543	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003544	putative active site [active]
497965003545	heme pocket [chemical binding]; other site
497965003546	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965003547	GAF domain; Region: GAF_3; pfam13492
497965003548	PAS fold; Region: PAS_4; pfam08448
497965003549	PAS fold; Region: PAS_3; pfam08447
497965003550	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003551	putative active site [active]
497965003552	heme pocket [chemical binding]; other site
497965003553	PAS fold; Region: PAS; pfam00989
497965003554	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
497965003555	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003556	PAS fold; Region: PAS_3; pfam08447
497965003557	putative active site [active]
497965003558	heme pocket [chemical binding]; other site
497965003559	PAS fold; Region: PAS_4; pfam08448
497965003560	PAS fold; Region: PAS_4; pfam08448
497965003561	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003562	putative active site [active]
497965003563	heme pocket [chemical binding]; other site
497965003564	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003565	putative active site [active]
497965003566	PAS fold; Region: PAS_3; pfam08447
497965003567	heme pocket [chemical binding]; other site
497965003568	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965003569	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965003570	dimer interface [polypeptide binding]; other site
497965003571	phosphorylation site [posttranslational modification]
497965003572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965003573	ATP binding site [chemical binding]; other site
497965003574	Mg2+ binding site [ion binding]; other site
497965003575	G-X-G motif; other site
497965003576	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965003577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965003578	active site
497965003579	phosphorylation site [posttranslational modification]
497965003580	intermolecular recognition site; other site
497965003581	dimerization interface [polypeptide binding]; other site
497965003582	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965003583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965003584	active site
497965003585	phosphorylation site [posttranslational modification]
497965003586	intermolecular recognition site; other site
497965003587	dimerization interface [polypeptide binding]; other site
497965003588	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965003589	DNA binding site [nucleotide binding]
497965003590	Hpt domain; Region: Hpt; pfam01627
497965003591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965003592	response regulator PleD; Reviewed; Region: pleD; PRK09581
497965003593	active site
497965003594	phosphorylation site [posttranslational modification]
497965003595	intermolecular recognition site; other site
497965003596	dimerization interface [polypeptide binding]; other site
497965003597	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965003598	active site
497965003599	phosphorylation site [posttranslational modification]
497965003600	intermolecular recognition site; other site
497965003601	dimerization interface [polypeptide binding]; other site
497965003602	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965003603	metal binding site [ion binding]; metal-binding site
497965003604	active site
497965003605	I-site; other site
497965003606	Cache domain; Region: Cache_1; pfam02743
497965003607	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965003608	dimerization interface [polypeptide binding]; other site
497965003609	PAS domain S-box; Region: sensory_box; TIGR00229
497965003610	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003611	putative active site [active]
497965003612	heme pocket [chemical binding]; other site
497965003613	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965003614	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003615	putative active site [active]
497965003616	heme pocket [chemical binding]; other site
497965003617	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003618	putative active site [active]
497965003619	heme pocket [chemical binding]; other site
497965003620	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965003621	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003622	putative active site [active]
497965003623	heme pocket [chemical binding]; other site
497965003624	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965003625	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003626	putative active site [active]
497965003627	heme pocket [chemical binding]; other site
497965003628	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003629	PAS domain; Region: PAS_9; pfam13426
497965003630	putative active site [active]
497965003631	heme pocket [chemical binding]; other site
497965003632	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965003633	PAS domain; Region: PAS_9; pfam13426
497965003634	putative active site [active]
497965003635	heme pocket [chemical binding]; other site
497965003636	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965003637	dimer interface [polypeptide binding]; other site
497965003638	phosphorylation site [posttranslational modification]
497965003639	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965003640	ATP binding site [chemical binding]; other site
497965003641	Mg2+ binding site [ion binding]; other site
497965003642	G-X-G motif; other site
497965003643	Response regulator receiver domain; Region: Response_reg; pfam00072
497965003644	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965003645	active site
497965003646	phosphorylation site [posttranslational modification]
497965003647	intermolecular recognition site; other site
497965003648	dimerization interface [polypeptide binding]; other site
497965003649	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965003650	putative active site [active]
497965003651	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
497965003652	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
497965003653	birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121
497965003654	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497965003655	Peptidase family M23; Region: Peptidase_M23; pfam01551
497965003656	Uncharacterized conserved protein [Function unknown]; Region: COG1262
497965003657	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
497965003658	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965003659	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
497965003660	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
497965003661	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
497965003662	NADP-binding site; other site
497965003663	homotetramer interface [polypeptide binding]; other site
497965003664	substrate binding site [chemical binding]; other site
497965003665	homodimer interface [polypeptide binding]; other site
497965003666	active site
497965003667	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965003668	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
497965003669	active site
497965003670	quinolinate synthetase; Provisional; Region: PRK09375
497965003671	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965003672	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965003673	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965003674	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
497965003675	isocitrate dehydrogenase; Validated; Region: PRK07362
497965003676	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965003677	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965003678	active site
497965003679	ATP binding site [chemical binding]; other site
497965003680	substrate binding site [chemical binding]; other site
497965003681	activation loop (A-loop); other site
497965003682	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
497965003683	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
497965003684	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965003685	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
497965003686	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965003687	DNA binding residues [nucleotide binding]
497965003688	Protein of unknown function (DUF760); Region: DUF760; pfam05542
497965003689	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
497965003690	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
497965003691	minor groove reading motif; other site
497965003692	helix-hairpin-helix signature motif; other site
497965003693	substrate binding pocket [chemical binding]; other site
497965003694	active site
497965003695	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
497965003696	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
497965003697	active site
497965003698	8-oxo-dGMP binding site [chemical binding]; other site
497965003699	nudix motif; other site
497965003700	metal binding site [ion binding]; metal-binding site
497965003701	putative hydrolase; Provisional; Region: PRK11460
497965003702	Predicted esterase [General function prediction only]; Region: COG0400
497965003703	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
497965003704	Protein of unknown function (DUF1326); Region: DUF1326; pfam07040
497965003705	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
497965003706	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
497965003707	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
497965003708	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497965003709	membrane-bound complex binding site; other site
497965003710	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497965003711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965003712	dimer interface [polypeptide binding]; other site
497965003713	conserved gate region; other site
497965003714	putative PBP binding loops; other site
497965003715	ABC-ATPase subunit interface; other site
497965003716	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
497965003717	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497965003718	Walker A/P-loop; other site
497965003719	ATP binding site [chemical binding]; other site
497965003720	Q-loop/lid; other site
497965003721	ABC transporter signature motif; other site
497965003722	Walker B; other site
497965003723	D-loop; other site
497965003724	H-loop/switch region; other site
497965003725	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
497965003726	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
497965003727	Flavin binding site [chemical binding]; other site
497965003728	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965003729	putative active site [active]
497965003730	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965003731	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
497965003732	Fasciclin domain; Region: Fasciclin; pfam02469
497965003733	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
497965003734	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
497965003735	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497965003736	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
497965003737	active site clefts [active]
497965003738	zinc binding site [ion binding]; other site
497965003739	dimer interface [polypeptide binding]; other site
497965003740	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
497965003741	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497965003742	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
497965003743	B1 nucleotide binding pocket [chemical binding]; other site
497965003744	B2 nucleotide binding pocket [chemical binding]; other site
497965003745	CAS motifs; other site
497965003746	active site
497965003747	magnesium chelatase subunit H; Provisional; Region: PLN03241
497965003748	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
497965003749	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
497965003750	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
497965003751	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
497965003752	ATP-NAD kinase; Region: NAD_kinase; pfam01513
497965003753	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
497965003754	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
497965003755	active site
497965003756	catalytic tetrad [active]
497965003757	recombinase A; Provisional; Region: recA; PRK09354
497965003758	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
497965003759	hexamer interface [polypeptide binding]; other site
497965003760	Walker A motif; other site
497965003761	ATP binding site [chemical binding]; other site
497965003762	Walker B motif; other site
497965003763	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
497965003764	Protein of unknown function, DUF488; Region: DUF488; cl01246
497965003765	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
497965003766	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965003767	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
497965003768	HSP70 interaction site [polypeptide binding]; other site
497965003769	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965003770	binding surface
497965003771	TPR motif; other site
497965003772	TPR repeat; Region: TPR_11; pfam13414
497965003773	WD domain, G-beta repeat; Region: WD40; pfam00400
497965003774	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
497965003775	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
497965003776	Cysteine-rich domain; Region: CCG; pfam02754
497965003777	Cysteine-rich domain; Region: CCG; pfam02754
497965003778	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
497965003779	FAD binding domain; Region: FAD_binding_4; pfam01565
497965003780	Protein of unknown function (DUF433); Region: DUF433; pfam04255
497965003781	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
497965003782	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
497965003783	ATP cone domain; Region: ATP-cone; pfam03477
497965003784	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
497965003785	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
497965003786	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
497965003787	protein-splicing catalytic site; other site
497965003788	thioester formation/cholesterol transfer; other site
497965003789	Ribonucleotide reductase, alpha subunit [Nucleotide transport and metabolism]; Region: NrdA; COG0209
497965003790	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
497965003791	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965003792	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
497965003793	dimer interface [polypeptide binding]; other site
497965003794	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
497965003795	putative radical transfer pathway; other site
497965003796	diiron center [ion binding]; other site
497965003797	tyrosyl radical; other site
497965003798	Predicted integral membrane protein [Function unknown]; Region: COG0392
497965003799	SOS regulatory protein LexA; Region: lexA; TIGR00498
497965003800	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
497965003801	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
497965003802	Catalytic site [active]
497965003803	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497965003804	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965003805	S-adenosylmethionine binding site [chemical binding]; other site
497965003806	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
497965003807	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
497965003808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
497965003809	putative carbohydrate kinase; Provisional; Region: PRK10565
497965003810	Uncharacterized conserved protein [Function unknown]; Region: COG0062
497965003811	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
497965003812	putative substrate binding site [chemical binding]; other site
497965003813	putative ATP binding site [chemical binding]; other site
497965003814	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
497965003815	Phosphoglycerate kinase; Region: PGK; pfam00162
497965003816	substrate binding site [chemical binding]; other site
497965003817	hinge regions; other site
497965003818	ADP binding site [chemical binding]; other site
497965003819	catalytic site [active]
497965003820	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497965003821	Ligand Binding Site [chemical binding]; other site
497965003822	PilZ domain; Region: PilZ; pfam07238
497965003823	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
497965003824	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
497965003825	GTP/Mg2+ binding site [chemical binding]; other site
497965003826	G4 box; other site
497965003827	G5 box; other site
497965003828	G1 box; other site
497965003829	Switch I region; other site
497965003830	G2 box; other site
497965003831	G3 box; other site
497965003832	Switch II region; other site
497965003833	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
497965003834	nudix motif; other site
497965003835	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
497965003836	Dehydroquinase class II; Region: DHquinase_II; pfam01220
497965003837	trimer interface [polypeptide binding]; other site
497965003838	active site
497965003839	dimer interface [polypeptide binding]; other site
497965003840	competence damage-inducible protein A; Provisional; Region: PRK00549
497965003841	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
497965003842	putative MPT binding site; other site
497965003843	Competence-damaged protein; Region: CinA; pfam02464
497965003844	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
497965003845	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
497965003846	Mg++ binding site [ion binding]; other site
497965003847	putative catalytic motif [active]
497965003848	substrate binding site [chemical binding]; other site
497965003849	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
497965003850	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
497965003851	dimer interface [polypeptide binding]; other site
497965003852	active site
497965003853	glycine-pyridoxal phosphate binding site [chemical binding]; other site
497965003854	folate binding site [chemical binding]; other site
497965003855	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
497965003856	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
497965003857	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
497965003858	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
497965003859	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965003860	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
497965003861	amidase; Provisional; Region: PRK09201
497965003862	Amidase; Region: Amidase; cl11426
497965003863	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
497965003864	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
497965003865	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
497965003866	Hexamer interface [polypeptide binding]; other site
497965003867	Hexagonal pore residue; other site
497965003868	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
497965003869	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
497965003870	Hexamer interface [polypeptide binding]; other site
497965003871	Hexagonal pore residue; other site
497965003872	XisI protein; Region: XisI; pfam08869
497965003873	XisH protein; Region: XisH; pfam08814
497965003874	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
497965003875	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
497965003876	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497965003877	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
497965003878	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
497965003879	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
497965003880	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
497965003881	B12 binding site [chemical binding]; other site
497965003882	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965003883	FeS/SAM binding site; other site
497965003884	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
497965003885	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965003886	Coenzyme A binding pocket [chemical binding]; other site
497965003887	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965003888	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965003889	dimer interface [polypeptide binding]; other site
497965003890	phosphorylation site [posttranslational modification]
497965003891	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
497965003892	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
497965003893	S-layer homology domain; Region: SLH; pfam00395
497965003894	S-layer homology domain; Region: SLH; pfam00395
497965003895	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
497965003896	dihydroorotase; Provisional; Region: PRK07369
497965003897	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
497965003898	active site
497965003899	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
497965003900	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
497965003901	catalytic residues [active]
497965003902	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
497965003903	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965003904	FeS/SAM binding site; other site
497965003905	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
497965003906	glucokinase; Provisional; Region: glk; PRK00292
497965003907	glucokinase, proteobacterial type; Region: glk; TIGR00749
497965003908	tellurium resistance terB-like protein; Region: terB_like; cd07177
497965003909	metal binding site [ion binding]; metal-binding site
497965003910	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
497965003911	GTPase CgtA; Reviewed; Region: obgE; PRK12299
497965003912	GTP1/OBG; Region: GTP1_OBG; pfam01018
497965003913	Obg GTPase; Region: Obg; cd01898
497965003914	G1 box; other site
497965003915	GTP/Mg2+ binding site [chemical binding]; other site
497965003916	Switch I region; other site
497965003917	G2 box; other site
497965003918	G3 box; other site
497965003919	Switch II region; other site
497965003920	G4 box; other site
497965003921	G5 box; other site
497965003922	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965003923	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965003924	Probable transposase; Region: OrfB_IS605; pfam01385
497965003925	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965003926	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
497965003927	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497965003928	active site
497965003929	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
497965003930	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
497965003931	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
497965003932	active site
497965003933	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
497965003934	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
497965003935	catalytic residues [active]
497965003936	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
497965003937	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
497965003938	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
497965003939	transmembrane helices; other site
497965003940	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
497965003941	transmembrane helices; other site
497965003942	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
497965003943	TrkA-C domain; Region: TrkA_C; pfam02080
497965003944	TrkA-C domain; Region: TrkA_C; pfam02080
497965003945	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
497965003946	Predicted permeases [General function prediction only]; Region: COG0701
497965003947	TIGR03943 family protein; Region: TIGR03943
497965003948	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
497965003949	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
497965003950	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
497965003951	RimM N-terminal domain; Region: RimM; pfam01782
497965003952	PRC-barrel domain; Region: PRC; pfam05239
497965003953	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
497965003954	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497965003955	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965003956	Walker A/P-loop; other site
497965003957	ATP binding site [chemical binding]; other site
497965003958	Q-loop/lid; other site
497965003959	ABC transporter signature motif; other site
497965003960	Walker B; other site
497965003961	D-loop; other site
497965003962	H-loop/switch region; other site
497965003963	chaperone protein DnaJ; Provisional; Region: PRK14299
497965003964	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965003965	HSP70 interaction site [polypeptide binding]; other site
497965003966	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
497965003967	substrate binding site [polypeptide binding]; other site
497965003968	dimer interface [polypeptide binding]; other site
497965003969	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
497965003970	iron-sulfur cluster [ion binding]; other site
497965003971	[2Fe-2S] cluster binding site [ion binding]; other site
497965003972	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
497965003973	Domain of unknown function DUF20; Region: UPF0118; pfam01594
497965003974	pyruvate kinase; Provisional; Region: PRK06354
497965003975	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
497965003976	domain interfaces; other site
497965003977	active site
497965003978	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
497965003979	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
497965003980	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
497965003981	DNA protecting protein DprA; Region: dprA; TIGR00732
497965003982	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965003983	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965003984	structural tetrad; other site
497965003985	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965003986	structural tetrad; other site
497965003987	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965003988	WD40 repeats; Region: WD40; smart00320
497965003989	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
497965003990	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
497965003991	Protein of unknown function, DUF608; Region: DUF608; pfam04685
497965003992	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
497965003993	Bacterial Ig-like domain; Region: Big_5; pfam13205
497965003994	MG2 domain; Region: A2M_N; pfam01835
497965003995	Alpha-2-macroglobulin family; Region: A2M; pfam00207
497965003996	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
497965003997	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
497965003998	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965003999	putative active site [active]
497965004000	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
497965004001	Transglycosylase; Region: Transgly; pfam00912
497965004002	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
497965004003	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
497965004004	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
497965004005	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965004006	ATP binding site [chemical binding]; other site
497965004007	putative Mg++ binding site [ion binding]; other site
497965004008	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965004009	nucleotide binding region [chemical binding]; other site
497965004010	ATP-binding site [chemical binding]; other site
497965004011	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
497965004012	active site
497965004013	catalytic triad [active]
497965004014	oxyanion hole [active]
497965004015	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
497965004016	catalytic center binding site [active]
497965004017	ATP binding site [chemical binding]; other site
497965004018	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
497965004019	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
497965004020	dimer interface [polypeptide binding]; other site
497965004021	ADP-ribose binding site [chemical binding]; other site
497965004022	active site
497965004023	nudix motif; other site
497965004024	metal binding site [ion binding]; metal-binding site
497965004025	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
497965004026	DNA photolyase; Region: DNA_photolyase; pfam00875
497965004027	Family description; Region: VCBS; pfam13517
497965004028	FG-GAP repeat; Region: FG-GAP; pfam01839
497965004029	Family description; Region: VCBS; pfam13517
497965004030	FG-GAP repeat; Region: FG-GAP; pfam01839
497965004031	Family description; Region: VCBS; pfam13517
497965004032	FG-GAP repeat; Region: FG-GAP; pfam01839
497965004033	Family description; Region: VCBS; pfam13517
497965004034	FG-GAP repeat; Region: FG-GAP; pfam01839
497965004035	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497965004036	Peptidase family M23; Region: Peptidase_M23; pfam01551
497965004037	glycogen branching enzyme; Provisional; Region: PRK12313
497965004038	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
497965004039	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
497965004040	active site
497965004041	catalytic site [active]
497965004042	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
497965004043	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
497965004044	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
497965004045	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
497965004046	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
497965004047	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
497965004048	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
497965004049	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
497965004050	RNA binding surface [nucleotide binding]; other site
497965004051	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
497965004052	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
497965004053	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
497965004054	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
497965004055	RNA binding surface [nucleotide binding]; other site
497965004056	hydroxyglutarate oxidase; Provisional; Region: PRK11728
497965004057	Predicted dehydrogenase [General function prediction only]; Region: COG0579
497965004058	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
497965004059	active site
497965004060	catalytic site [active]
497965004061	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
497965004062	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965004063	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965004064	active site
497965004065	ATP binding site [chemical binding]; other site
497965004066	substrate binding site [chemical binding]; other site
497965004067	activation loop (A-loop); other site
497965004068	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965004069	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965004070	structural tetrad; other site
497965004071	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965004072	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965004073	structural tetrad; other site
497965004074	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
497965004075	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
497965004076	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
497965004077	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965004078	Walker A/P-loop; other site
497965004079	ATP binding site [chemical binding]; other site
497965004080	Q-loop/lid; other site
497965004081	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497965004082	ABC transporter; Region: ABC_tran_2; pfam12848
497965004083	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497965004084	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965004085	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965004086	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965004087	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965004088	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965004089	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965004090	putative active site [active]
497965004091	Integral membrane protein TerC family; Region: TerC; cl10468
497965004092	Domain of unknown function (DUF202); Region: DUF202; pfam02656
497965004093	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
497965004094	Cadmium resistance transporter; Region: Cad; pfam03596
497965004095	Cadmium resistance transporter; Region: Cad; pfam03596
497965004096	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
497965004097	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
497965004098	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497965004099	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
497965004100	putative dimerization interface [polypeptide binding]; other site
497965004101	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
497965004102	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
497965004103	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
497965004104	Walker A/P-loop; other site
497965004105	ATP binding site [chemical binding]; other site
497965004106	Q-loop/lid; other site
497965004107	ABC transporter signature motif; other site
497965004108	Walker B; other site
497965004109	D-loop; other site
497965004110	H-loop/switch region; other site
497965004111	aminotransferase; Validated; Region: PRK07777
497965004112	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497965004113	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965004114	homodimer interface [polypeptide binding]; other site
497965004115	catalytic residue [active]
497965004116	Transcriptional regulator; Region: Rrf2; pfam02082
497965004117	Rrf2 family protein; Region: rrf2_super; TIGR00738
497965004118	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965004119	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
497965004120	ligand binding site [chemical binding]; other site
497965004121	flexible hinge region; other site
497965004122	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
497965004123	non-specific DNA interactions [nucleotide binding]; other site
497965004124	DNA binding site [nucleotide binding]
497965004125	sequence specific DNA binding site [nucleotide binding]; other site
497965004126	putative cAMP binding site [chemical binding]; other site
497965004127	serine O-acetyltransferase; Region: cysE; TIGR01172
497965004128	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
497965004129	trimer interface [polypeptide binding]; other site
497965004130	active site
497965004131	substrate binding site [chemical binding]; other site
497965004132	CoA binding site [chemical binding]; other site
497965004133	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
497965004134	Predicted transcriptional regulator [Transcription]; Region: COG1959
497965004135	Transcriptional regulator; Region: Rrf2; pfam02082
497965004136	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
497965004137	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
497965004138	hinge; other site
497965004139	active site
497965004140	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
497965004141	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
497965004142	AAA domain; Region: AAA_31; pfam13614
497965004143	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965004144	P-loop; other site
497965004145	Magnesium ion binding site [ion binding]; other site
497965004146	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965004147	Magnesium ion binding site [ion binding]; other site
497965004148	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
497965004149	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
497965004150	Cupin domain; Region: Cupin_2; pfam07883
497965004151	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
497965004152	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
497965004153	active site
497965004154	motif I; other site
497965004155	motif II; other site
497965004156	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
497965004157	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
497965004158	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
497965004159	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
497965004160	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
497965004161	active site
497965004162	Substrate binding site; other site
497965004163	Mg++ binding site; other site
497965004164	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
497965004165	putative trimer interface [polypeptide binding]; other site
497965004166	putative CoA binding site [chemical binding]; other site
497965004167	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
497965004168	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
497965004169	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
497965004170	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
497965004171	dimer interface [polypeptide binding]; other site
497965004172	ssDNA binding site [nucleotide binding]; other site
497965004173	tetramer (dimer of dimers) interface [polypeptide binding]; other site
497965004174	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
497965004175	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
497965004176	putative catalytic cysteine [active]
497965004177	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
497965004178	putative active site [active]
497965004179	metal binding site [ion binding]; metal-binding site
497965004180	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
497965004181	tartrate dehydrogenase; Region: TTC; TIGR02089
497965004182	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
497965004183	catalytic triad [active]
497965004184	putative active site [active]
497965004185	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
497965004186	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
497965004187	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
497965004188	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
497965004189	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965004190	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
497965004191	ArsC family; Region: ArsC; pfam03960
497965004192	putative catalytic residues [active]
497965004193	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
497965004194	dihydropteroate synthase; Region: DHPS; TIGR01496
497965004195	substrate binding pocket [chemical binding]; other site
497965004196	dimer interface [polypeptide binding]; other site
497965004197	inhibitor binding site; inhibition site
497965004198	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
497965004199	GUN4-like; Region: GUN4; pfam05419
497965004200	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
497965004201	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
497965004202	putative active site; other site
497965004203	catalytic residue [active]
497965004204	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
497965004205	Peptidase family M50; Region: Peptidase_M50; pfam02163
497965004206	active site
497965004207	putative substrate binding region [chemical binding]; other site
497965004208	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
497965004209	DNA adenine methylase (dam); Region: dam; TIGR00571
497965004210	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
497965004211	active site
497965004212	dimer interface [polypeptide binding]; other site
497965004213	metal binding site [ion binding]; metal-binding site
497965004214	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
497965004215	EamA-like transporter family; Region: EamA; pfam00892
497965004216	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965004217	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
497965004218	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
497965004219	MgtC family; Region: MgtC; pfam02308
497965004220	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965004221	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965004222	ligand binding site [chemical binding]; other site
497965004223	flexible hinge region; other site
497965004224	phosphoenolpyruvate synthase; Validated; Region: PRK06464
497965004225	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
497965004226	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
497965004227	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
497965004228	Protein of unknown function DUF262; Region: DUF262; pfam03235
497965004229	Uncharacterized conserved protein [Function unknown]; Region: COG1479
497965004230	Protein of unknown function DUF262; Region: DUF262; pfam03235
497965004231	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
497965004232	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965004233	putative active site [active]
497965004234	aspartate aminotransferase; Provisional; Region: PRK05942
497965004235	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497965004236	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965004237	homodimer interface [polypeptide binding]; other site
497965004238	catalytic residue [active]
497965004239	enolase; Provisional; Region: eno; PRK00077
497965004240	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
497965004241	dimer interface [polypeptide binding]; other site
497965004242	metal binding site [ion binding]; metal-binding site
497965004243	substrate binding pocket [chemical binding]; other site
497965004244	Fn3 associated; Region: Fn3_assoc; pfam13287
497965004245	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
497965004246	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
497965004247	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
497965004248	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
497965004249	active site
497965004250	catalytic site [active]
497965004251	CHASE domain; Region: CHASE; cl01369
497965004252	PAS domain; Region: PAS_9; pfam13426
497965004253	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965004254	putative active site [active]
497965004255	heme pocket [chemical binding]; other site
497965004256	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965004257	PAS domain; Region: PAS_9; pfam13426
497965004258	putative active site [active]
497965004259	heme pocket [chemical binding]; other site
497965004260	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965004261	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965004262	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965004263	dimer interface [polypeptide binding]; other site
497965004264	phosphorylation site [posttranslational modification]
497965004265	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965004266	ATP binding site [chemical binding]; other site
497965004267	Mg2+ binding site [ion binding]; other site
497965004268	G-X-G motif; other site
497965004269	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965004270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965004271	active site
497965004272	phosphorylation site [posttranslational modification]
497965004273	intermolecular recognition site; other site
497965004274	dimerization interface [polypeptide binding]; other site
497965004275	Response regulator receiver domain; Region: Response_reg; pfam00072
497965004276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965004277	active site
497965004278	phosphorylation site [posttranslational modification]
497965004279	intermolecular recognition site; other site
497965004280	dimerization interface [polypeptide binding]; other site
497965004281	Response regulator receiver domain; Region: Response_reg; pfam00072
497965004282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965004283	active site
497965004284	phosphorylation site [posttranslational modification]
497965004285	intermolecular recognition site; other site
497965004286	dimerization interface [polypeptide binding]; other site
497965004287	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965004288	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965004289	metal binding site [ion binding]; metal-binding site
497965004290	active site
497965004291	I-site; other site
497965004292	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
497965004293	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
497965004294	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
497965004295	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
497965004296	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
497965004297	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
497965004298	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
497965004299	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
497965004300	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965004301	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
497965004302	HEAT repeats; Region: HEAT_2; pfam13646
497965004303	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
497965004304	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
497965004305	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
497965004306	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
497965004307	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
497965004308	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
497965004309	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
497965004310	Phycobilisome protein; Region: Phycobilisome; cl08227
497965004311	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
497965004312	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
497965004313	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965004314	S-adenosylmethionine binding site [chemical binding]; other site
497965004315	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965004316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965004317	active site
497965004318	phosphorylation site [posttranslational modification]
497965004319	intermolecular recognition site; other site
497965004320	dimerization interface [polypeptide binding]; other site
497965004321	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965004322	DNA binding residues [nucleotide binding]
497965004323	dimerization interface [polypeptide binding]; other site
497965004324	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965004325	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965004326	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
497965004327	intersubunit interface [polypeptide binding]; other site
497965004328	active site
497965004329	zinc binding site [ion binding]; other site
497965004330	Na+ binding site [ion binding]; other site
497965004331	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497965004332	hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824
497965004333	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
497965004334	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
497965004335	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
497965004336	iron-sulfur cluster [ion binding]; other site
497965004337	[2Fe-2S] cluster binding site [ion binding]; other site
497965004338	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
497965004339	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
497965004340	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
497965004341	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
497965004342	This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063
497965004343	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
497965004344	nickel binding site [ion binding]; other site
497965004345	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
497965004346	heme binding pocket [chemical binding]; other site
497965004347	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
497965004348	TM2 domain; Region: TM2; cl00984
497965004349	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
497965004350	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
497965004351	putative active site [active]
497965004352	adenylation catalytic residue [active]
497965004353	seryl-tRNA synthetase; Provisional; Region: PRK05431
497965004354	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
497965004355	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
497965004356	dimer interface [polypeptide binding]; other site
497965004357	active site
497965004358	motif 1; other site
497965004359	motif 2; other site
497965004360	motif 3; other site
497965004361	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965004362	putative active site [active]
497965004363	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
497965004364	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
497965004365	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
497965004366	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
497965004367	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
497965004368	Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596
497965004369	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
497965004370	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
497965004371	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
497965004372	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
497965004373	triosephosphate isomerase; Provisional; Region: PRK14565
497965004374	dimer interface [polypeptide binding]; other site
497965004375	substrate binding site [chemical binding]; other site
497965004376	catalytic triad [active]
497965004377	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
497965004378	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
497965004379	trmE is a tRNA modification GTPase; Region: trmE; cd04164
497965004380	G1 box; other site
497965004381	GTP/Mg2+ binding site [chemical binding]; other site
497965004382	Switch I region; other site
497965004383	G2 box; other site
497965004384	Switch II region; other site
497965004385	G3 box; other site
497965004386	G4 box; other site
497965004387	G5 box; other site
497965004388	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
497965004389	CpeS-like protein; Region: CpeS; pfam09367
497965004390	HEAT repeats; Region: HEAT_2; pfam13646
497965004391	HEAT repeats; Region: HEAT_2; pfam13646
497965004392	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
497965004393	HEAT repeats; Region: HEAT_2; pfam13646
497965004394	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
497965004395	trimer interface [polypeptide binding]; other site
497965004396	active site
497965004397	substrate binding site [chemical binding]; other site
497965004398	CoA binding site [chemical binding]; other site
497965004399	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
497965004400	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
497965004401	photosystem II 44 kDa protein; Region: psbC; CHL00035
497965004402	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
497965004403	Photosystem II, DII subunit (also called Q(A)); Region: psbD; TIGR01152
497965004404	pheophytin binding site; other site
497965004405	chlorophyll binding site; other site
497965004406	quinone binding site; other site
497965004407	Fe binding site [ion binding]; other site
497965004408	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
497965004409	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
497965004410	active site
497965004411	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
497965004412	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
497965004413	dimer interface [polypeptide binding]; other site
497965004414	active site
497965004415	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965004416	HSP70 interaction site [polypeptide binding]; other site
497965004417	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
497965004418	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
497965004419	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
497965004420	tetramer interface [polypeptide binding]; other site
497965004421	TPP-binding site [chemical binding]; other site
497965004422	heterodimer interface [polypeptide binding]; other site
497965004423	phosphorylation loop region [posttranslational modification]
497965004424	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
497965004425	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
497965004426	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
497965004427	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965004428	Inward rectifier potassium channel; Region: IRK; pfam01007
497965004429	Penicillin amidase; Region: Penicil_amidase; pfam01804
497965004430	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
497965004431	active site
497965004432	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
497965004433	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
497965004434	Cadmium resistance transporter; Region: Cad; pfam03596
497965004435	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497965004436	active site
497965004437	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
497965004438	recombination protein RecR; Reviewed; Region: recR; PRK00076
497965004439	RecR protein; Region: RecR; pfam02132
497965004440	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
497965004441	putative active site [active]
497965004442	putative metal-binding site [ion binding]; other site
497965004443	tetramer interface [polypeptide binding]; other site
497965004444	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
497965004445	MoaE interaction surface [polypeptide binding]; other site
497965004446	MoeB interaction surface [polypeptide binding]; other site
497965004447	thiocarboxylated glycine; other site
497965004448	threonine synthase; Validated; Region: PRK07591
497965004449	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
497965004450	homodimer interface [polypeptide binding]; other site
497965004451	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965004452	catalytic residue [active]
497965004453	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
497965004454	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497965004455	substrate binding pocket [chemical binding]; other site
497965004456	membrane-bound complex binding site; other site
497965004457	hinge residues; other site
497965004458	PAS domain S-box; Region: sensory_box; TIGR00229
497965004459	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965004460	putative active site [active]
497965004461	heme pocket [chemical binding]; other site
497965004462	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965004463	PAS fold; Region: PAS_3; pfam08447
497965004464	putative active site [active]
497965004465	heme pocket [chemical binding]; other site
497965004466	PAS domain; Region: PAS_8; pfam13188
497965004467	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965004468	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965004469	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965004470	putative active site [active]
497965004471	heme pocket [chemical binding]; other site
497965004472	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965004473	putative active site [active]
497965004474	heme pocket [chemical binding]; other site
497965004475	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965004476	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965004477	metal binding site [ion binding]; metal-binding site
497965004478	active site
497965004479	I-site; other site
497965004480	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965004481	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
497965004482	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
497965004483	Walker A motif; other site
497965004484	ATP binding site [chemical binding]; other site
497965004485	Walker B motif; other site
497965004486	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965004487	ATP binding site [chemical binding]; other site
497965004488	Walker B motif; other site
497965004489	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
497965004490	tetramer interface [polypeptide binding]; other site
497965004491	dimer interface [polypeptide binding]; other site
497965004492	KaiA domain; Region: KaiA; pfam07688
497965004493	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
497965004494	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
497965004495	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965004496	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965004497	dimer interface [polypeptide binding]; other site
497965004498	phosphorylation site [posttranslational modification]
497965004499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965004500	ATP binding site [chemical binding]; other site
497965004501	Mg2+ binding site [ion binding]; other site
497965004502	G-X-G motif; other site
497965004503	Response regulator receiver domain; Region: Response_reg; pfam00072
497965004504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965004505	active site
497965004506	phosphorylation site [posttranslational modification]
497965004507	intermolecular recognition site; other site
497965004508	dimerization interface [polypeptide binding]; other site
497965004509	RDD family; Region: RDD; pfam06271
497965004510	Probable transposase; Region: OrfB_IS605; pfam01385
497965004511	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965004512	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
497965004513	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
497965004514	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
497965004515	catalytic residues [active]
497965004516	catalytic nucleophile [active]
497965004517	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
497965004518	C-terminal peptidase (prc); Region: prc; TIGR00225
497965004519	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
497965004520	protein binding site [polypeptide binding]; other site
497965004521	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
497965004522	Catalytic dyad [active]
497965004523	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
497965004524	nudix motif; other site
497965004525	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
497965004526	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
497965004527	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
497965004528	homodimer interface [polypeptide binding]; other site
497965004529	NADP binding site [chemical binding]; other site
497965004530	substrate binding site [chemical binding]; other site
497965004531	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
497965004532	Double zinc ribbon; Region: DZR; pfam12773
497965004533	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
497965004534	Protein phosphatase 2C; Region: PP2C; pfam00481
497965004535	active site
497965004536	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965004537	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965004538	active site
497965004539	ATP binding site [chemical binding]; other site
497965004540	substrate binding site [chemical binding]; other site
497965004541	activation loop (A-loop); other site
497965004542	NAD synthetase; Provisional; Region: PRK13981
497965004543	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
497965004544	multimer interface [polypeptide binding]; other site
497965004545	active site
497965004546	catalytic triad [active]
497965004547	protein interface 1 [polypeptide binding]; other site
497965004548	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
497965004549	homodimer interface [polypeptide binding]; other site
497965004550	NAD binding pocket [chemical binding]; other site
497965004551	ATP binding pocket [chemical binding]; other site
497965004552	Mg binding site [ion binding]; other site
497965004553	active-site loop [active]
497965004554	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
497965004555	nudix motif; other site
497965004556	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
497965004557	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
497965004558	active site
497965004559	(T/H)XGH motif; other site
497965004560	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
497965004561	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
497965004562	active site
497965004563	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
497965004564	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
497965004565	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965004566	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497965004567	Protein of unknown function (DUF552); Region: DUF552; pfam04472
497965004568	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
497965004569	Uncharacterized conserved protein [Function unknown]; Region: COG3937
497965004570	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
497965004571	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
497965004572	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
497965004573	Ligand Binding Site [chemical binding]; other site
497965004574	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497965004575	Ligand Binding Site [chemical binding]; other site
497965004576	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497965004577	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497965004578	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
497965004579	Walker A/P-loop; other site
497965004580	ATP binding site [chemical binding]; other site
497965004581	Q-loop/lid; other site
497965004582	ABC transporter signature motif; other site
497965004583	Walker B; other site
497965004584	D-loop; other site
497965004585	H-loop/switch region; other site
497965004586	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497965004587	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
497965004588	Walker A/P-loop; other site
497965004589	ATP binding site [chemical binding]; other site
497965004590	Q-loop/lid; other site
497965004591	ABC transporter signature motif; other site
497965004592	Walker B; other site
497965004593	D-loop; other site
497965004594	H-loop/switch region; other site
497965004595	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
497965004596	NMT1-like family; Region: NMT1_2; pfam13379
497965004597	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497965004598	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965004599	dimer interface [polypeptide binding]; other site
497965004600	conserved gate region; other site
497965004601	ABC-ATPase subunit interface; other site
497965004602	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
497965004603	NMT1-like family; Region: NMT1_2; pfam13379
497965004604	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
497965004605	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
497965004606	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
497965004607	CHASE2 domain; Region: CHASE2; pfam05226
497965004608	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
497965004609	TPR repeat; Region: TPR_11; pfam13414
497965004610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965004611	binding surface
497965004612	TPR motif; other site
497965004613	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965004614	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
497965004615	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
497965004616	antiporter inner membrane protein; Provisional; Region: PRK11670
497965004617	Domain of unknown function DUF59; Region: DUF59; pfam01883
497965004618	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
497965004619	Walker A motif; other site
497965004620	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
497965004621	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
497965004622	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
497965004623	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965004624	active site
497965004625	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
497965004626	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497965004627	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965004628	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
497965004629	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
497965004630	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
497965004631	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965004632	Walker A motif; other site
497965004633	ATP binding site [chemical binding]; other site
497965004634	Walker B motif; other site
497965004635	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
497965004636	Clp protease; Region: CLP_protease; pfam00574
497965004637	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
497965004638	oligomer interface [polypeptide binding]; other site
497965004639	active site residues [active]
497965004640	trigger factor; Provisional; Region: tig; PRK01490
497965004641	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
497965004642	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
497965004643	META domain; Region: META; pfam03724
497965004644	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
497965004645	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
497965004646	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
497965004647	dihydrodipicolinate synthase; Region: dapA; TIGR00674
497965004648	dimer interface [polypeptide binding]; other site
497965004649	active site
497965004650	catalytic residue [active]
497965004651	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
497965004652	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
497965004653	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
497965004654	Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131
497965004655	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
497965004656	NAD binding site [chemical binding]; other site
497965004657	catalytic residues [active]
497965004658	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
497965004659	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965004660	dimerization interface [polypeptide binding]; other site
497965004661	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
497965004662	cyclase homology domain; Region: CHD; cd07302
497965004663	nucleotidyl binding site; other site
497965004664	metal binding site [ion binding]; metal-binding site
497965004665	dimer interface [polypeptide binding]; other site
497965004666	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497965004667	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965004668	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965004669	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965004670	ligand binding site [chemical binding]; other site
497965004671	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965004672	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965004673	active site
497965004674	ATP binding site [chemical binding]; other site
497965004675	substrate binding site [chemical binding]; other site
497965004676	activation loop (A-loop); other site
497965004677	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
497965004678	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
497965004679	putative ligand binding site [chemical binding]; other site
497965004680	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
497965004681	Protein kinase domain; Region: Pkinase; pfam00069
497965004682	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965004683	active site
497965004684	ATP binding site [chemical binding]; other site
497965004685	substrate binding site [chemical binding]; other site
497965004686	activation loop (A-loop); other site
497965004687	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
497965004688	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
497965004689	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
497965004690	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
497965004691	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
497965004692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
497965004693	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
497965004694	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
497965004695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
497965004696	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
497965004697	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
497965004698	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
497965004699	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
497965004700	Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948
497965004701	homocitrate synthase; Region: LysS_fung_arch; TIGR02146
497965004702	active site
497965004703	catalytic residues [active]
497965004704	metal binding site [ion binding]; metal-binding site
497965004705	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497965004706	Ligand Binding Site [chemical binding]; other site
497965004707	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
497965004708	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
497965004709	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
497965004710	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
497965004711	G1 box; other site
497965004712	GTP/Mg2+ binding site [chemical binding]; other site
497965004713	Switch I region; other site
497965004714	Switch II region; other site
497965004715	G4 box; other site
497965004716	G5 box; other site
497965004717	Domain of unknown function (DUF697); Region: DUF697; pfam05128
497965004718	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
497965004719	DNA methylase; Region: N6_N4_Mtase; pfam01555
497965004720	Bacitracin resistance protein BacA; Region: BacA; pfam02673
497965004721	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
497965004722	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965004723	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965004724	phosphopeptide binding site; other site
497965004725	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
497965004726	cyclase homology domain; Region: CHD; cd07302
497965004727	nucleotidyl binding site; other site
497965004728	metal binding site [ion binding]; metal-binding site
497965004729	dimer interface [polypeptide binding]; other site
497965004730	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
497965004731	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
497965004732	30S subunit binding site; other site
497965004733	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
497965004734	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
497965004735	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
497965004736	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
497965004737	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965004738	Walker A motif; other site
497965004739	ATP binding site [chemical binding]; other site
497965004740	Walker B motif; other site
497965004741	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
497965004742	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
497965004743	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
497965004744	Walker A motif; other site
497965004745	ATP binding site [chemical binding]; other site
497965004746	Walker B motif; other site
497965004747	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
497965004748	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
497965004749	dimer interface [polypeptide binding]; other site
497965004750	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
497965004751	molecular chaperone DnaK; Provisional; Region: PRK13411
497965004752	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
497965004753	nucleotide binding site [chemical binding]; other site
497965004754	NEF interaction site [polypeptide binding]; other site
497965004755	SBD interface [polypeptide binding]; other site
497965004756	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
497965004757	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
497965004758	Catalytic site [active]
497965004759	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
497965004760	AIR carboxylase; Region: AIRC; smart01001
497965004761	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
497965004762	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497965004763	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497965004764	TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949
497965004765	catalytic residues [active]
497965004766	Uncharacterized conserved protein [Function unknown]; Region: COG1434
497965004767	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
497965004768	putative active site [active]
497965004769	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
497965004770	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965004771	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
497965004772	active site
497965004773	ATP binding site [chemical binding]; other site
497965004774	substrate binding site [chemical binding]; other site
497965004775	activation loop (A-loop); other site
497965004776	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965004777	phosphopeptide binding site; other site
497965004778	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
497965004779	DNA binding site [nucleotide binding]
497965004780	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
497965004781	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
497965004782	Double zinc ribbon; Region: DZR; pfam12773
497965004783	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965004784	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965004785	phosphopeptide binding site; other site
497965004786	Uncharacterized conserved protein [Function unknown]; Region: COG2006
497965004787	Domain of unknown function (DUF362); Region: DUF362; pfam04015
497965004788	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
497965004789	putative catalytic site [active]
497965004790	putative metal binding site [ion binding]; other site
497965004791	putative phosphate binding site [ion binding]; other site
497965004792	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
497965004793	protein I interface; other site
497965004794	D2 interface; other site
497965004795	protein T interface; other site
497965004796	chlorophyll binding site; other site
497965004797	beta carotene binding site; other site
497965004798	pheophytin binding site; other site
497965004799	manganese-stabilizing polypeptide interface; other site
497965004800	CP43 interface; other site
497965004801	protein L interface; other site
497965004802	oxygen evolving complex binding site; other site
497965004803	bromide binding site; other site
497965004804	quinone binding site; other site
497965004805	Fe binding site [ion binding]; other site
497965004806	core light harvesting interface; other site
497965004807	cytochrome b559 alpha subunit interface; other site
497965004808	cytochrome c-550 interface; other site
497965004809	protein J interface; other site
497965004810	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
497965004811	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
497965004812	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
497965004813	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965004814	HSP70 interaction site [polypeptide binding]; other site
497965004815	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965004816	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965004817	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965004818	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965004819	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
497965004820	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497965004821	dimerization interface [polypeptide binding]; other site
497965004822	putative DNA binding site [nucleotide binding]; other site
497965004823	putative Zn2+ binding site [ion binding]; other site
497965004824	Domain of unknown function DUF20; Region: UPF0118; pfam01594
497965004825	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
497965004826	classical (c) SDRs; Region: SDR_c; cd05233
497965004827	short chain dehydrogenase; Provisional; Region: PRK07832
497965004828	NAD(P) binding site [chemical binding]; other site
497965004829	active site
497965004830	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
497965004831	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
497965004832	Circadian oscillating protein COP23; Region: COP23; pfam14218
497965004833	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
497965004834	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965004835	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965004836	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
497965004837	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
497965004838	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
497965004839	Ycf39; Provisional; Region: ycf39; CHL00194
497965004840	NAD(P) binding site [chemical binding]; other site
497965004841	putative active site [active]
497965004842	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504
497965004843	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
497965004844	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
497965004845	HIGH motif; other site
497965004846	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
497965004847	active site
497965004848	KMSKS motif; other site
497965004849	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
497965004850	DNA methylase; Region: N6_N4_Mtase; pfam01555
497965004851	acyl-CoA synthetase; Validated; Region: PRK05850
497965004852	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
497965004853	acyl-activating enzyme (AAE) consensus motif; other site
497965004854	active site
497965004855	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
497965004856	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
497965004857	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
497965004858	active site
497965004859	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
497965004860	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
497965004861	KR domain; Region: KR; pfam08659
497965004862	putative NADP binding site [chemical binding]; other site
497965004863	active site
497965004864	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
497965004865	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
497965004866	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965004867	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497965004868	Immunoglobulin domain; Region: Ig; cl11960
497965004869	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965004870	Uncharacterized conserved protein [Function unknown]; Region: COG3349
497965004871	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965004872	TIGR04255 family protein; Region: sporadTIGR04255
497965004873	HEAT repeats; Region: HEAT_2; pfam13646
497965004874	HEAT repeats; Region: HEAT_2; pfam13646
497965004875	HEAT repeats; Region: HEAT_2; pfam13646
497965004876	HEAT repeats; Region: HEAT_2; pfam13646
497965004877	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
497965004878	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
497965004879	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965004880	motif II; other site
497965004881	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497965004882	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965004883	S-adenosylmethionine binding site [chemical binding]; other site
497965004884	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
497965004885	tetramerization interface [polypeptide binding]; other site
497965004886	active site
497965004887	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
497965004888	putative glycosyl transferase; Provisional; Region: PRK10307
497965004889	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
497965004890	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
497965004891	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
497965004892	dimerization interface [polypeptide binding]; other site
497965004893	ATP binding site [chemical binding]; other site
497965004894	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
497965004895	dimerization interface [polypeptide binding]; other site
497965004896	ATP binding site [chemical binding]; other site
497965004897	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
497965004898	GIY-YIG motif/motif A; other site
497965004899	active site
497965004900	catalytic site [active]
497965004901	metal binding site [ion binding]; metal-binding site
497965004902	amidophosphoribosyltransferase; Provisional; Region: PRK07349
497965004903	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
497965004904	active site
497965004905	tetramer interface [polypeptide binding]; other site
497965004906	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497965004907	active site
497965004908	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
497965004909	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
497965004910	Helix-turn-helix domain; Region: HTH_25; pfam13413
497965004911	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
497965004912	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
497965004913	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
497965004914	RNA binding surface [nucleotide binding]; other site
497965004915	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
497965004916	active site
497965004917	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
497965004918	catalytic triad [active]
497965004919	dimer interface [polypeptide binding]; other site
497965004920	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
497965004921	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
497965004922	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
497965004923	dimerization interface [polypeptide binding]; other site
497965004924	DPS ferroxidase diiron center [ion binding]; other site
497965004925	ion pore; other site
497965004926	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
497965004927	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
497965004928	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
497965004929	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
497965004930	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
497965004931	Cl- selectivity filter; other site
497965004932	Cl- binding residues [ion binding]; other site
497965004933	pore gating glutamate residue; other site
497965004934	dimer interface [polypeptide binding]; other site
497965004935	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
497965004936	DNA methylase; Region: N6_N4_Mtase; pfam01555
497965004937	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497965004938	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965004939	non-specific DNA binding site [nucleotide binding]; other site
497965004940	salt bridge; other site
497965004941	sequence-specific DNA binding site [nucleotide binding]; other site
497965004942	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
497965004943	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
497965004944	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
497965004945	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965004946	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965004947	active site
497965004948	phosphorylation site [posttranslational modification]
497965004949	intermolecular recognition site; other site
497965004950	dimerization interface [polypeptide binding]; other site
497965004951	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965004952	DNA binding site [nucleotide binding]
497965004953	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
497965004954	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
497965004955	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
497965004956	nucleoside/Zn binding site; other site
497965004957	dimer interface [polypeptide binding]; other site
497965004958	catalytic motif [active]
497965004959	Response regulator receiver domain; Region: Response_reg; pfam00072
497965004960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965004961	active site
497965004962	phosphorylation site [posttranslational modification]
497965004963	intermolecular recognition site; other site
497965004964	dimerization interface [polypeptide binding]; other site
497965004965	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965004966	DNA binding residues [nucleotide binding]
497965004967	MASE1; Region: MASE1; pfam05231
497965004968	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965004969	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965004970	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965004971	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965004972	dimer interface [polypeptide binding]; other site
497965004973	phosphorylation site [posttranslational modification]
497965004974	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965004975	ATP binding site [chemical binding]; other site
497965004976	Mg2+ binding site [ion binding]; other site
497965004977	G-X-G motif; other site
497965004978	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
497965004979	Acyltransferase family; Region: Acyl_transf_3; pfam01757
497965004980	N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional; Region: PRK04338
497965004981	Uncharacterized conserved protein [Function unknown]; Region: COG1543
497965004982	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
497965004983	active site
497965004984	substrate binding site [chemical binding]; other site
497965004985	catalytic site [active]
497965004986	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
497965004987	adaptive-response sensory kinase; Validated; Region: PRK09303
497965004988	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
497965004989	tetramer interface [polypeptide binding]; other site
497965004990	dimer interface [polypeptide binding]; other site
497965004991	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965004992	dimer interface [polypeptide binding]; other site
497965004993	phosphorylation site [posttranslational modification]
497965004994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965004995	ATP binding site [chemical binding]; other site
497965004996	Mg2+ binding site [ion binding]; other site
497965004997	G-X-G motif; other site
497965004998	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
497965004999	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
497965005000	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
497965005001	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
497965005002	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
497965005003	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
497965005004	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
497965005005	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
497965005006	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497965005007	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
497965005008	C-terminal domain interface [polypeptide binding]; other site
497965005009	GSH binding site (G-site) [chemical binding]; other site
497965005010	dimer interface [polypeptide binding]; other site
497965005011	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
497965005012	N-terminal domain interface [polypeptide binding]; other site
497965005013	cytosine deaminase-like protein; Validated; Region: PRK07583
497965005014	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
497965005015	active site
497965005016	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
497965005017	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
497965005018	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
497965005019	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
497965005020	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
497965005021	Chain length determinant protein; Region: Wzz; pfam02706
497965005022	AAA domain; Region: AAA_31; pfam13614
497965005023	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
497965005024	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
497965005025	active site
497965005026	catalytic tetrad [active]
497965005027	Bifunctional nuclease; Region: DNase-RNase; pfam02577
497965005028	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
497965005029	Lumazine binding domain; Region: Lum_binding; pfam00677
497965005030	Lumazine binding domain; Region: Lum_binding; pfam00677
497965005031	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965005032	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965005033	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965005034	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965005035	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965005036	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
497965005037	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497965005038	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
497965005039	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
497965005040	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
497965005041	Uncharacterized conserved protein [Function unknown]; Region: COG2326
497965005042	Protein of unknown function (DUF552); Region: DUF552; pfam04472
497965005043	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
497965005044	NADPH bind site [chemical binding]; other site
497965005045	putative FMN binding site [chemical binding]; other site
497965005046	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
497965005047	putative FMN binding site [chemical binding]; other site
497965005048	NADPH bind site [chemical binding]; other site
497965005049	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
497965005050	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
497965005051	MviN-like protein; Region: MVIN; pfam03023
497965005052	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
497965005053	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
497965005054	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
497965005055	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
497965005056	active site
497965005057	Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459
497965005058	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
497965005059	haemagglutination activity domain; Region: Haemagg_act; pfam05860
497965005060	CHAT domain; Region: CHAT; cl17868
497965005061	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
497965005062	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
497965005063	Surface antigen; Region: Bac_surface_Ag; pfam01103
497965005064	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
497965005065	active site
497965005066	ATP binding site [chemical binding]; other site
497965005067	PBP superfamily domain; Region: PBP_like_2; cl17296
497965005068	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965005069	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965005070	phosphopeptide binding site; other site
497965005071	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
497965005072	Phage protein D [General function prediction only]; Region: COG3500
497965005073	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
497965005074	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
497965005075	Bacterial Ig-like domain; Region: Big_5; pfam13205
497965005076	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
497965005077	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965005078	Probable transposase; Region: OrfB_IS605; pfam01385
497965005079	hydrolase, alpha/beta fold family protein; Region: PLN02824
497965005080	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497965005081	Ligand Binding Site [chemical binding]; other site
497965005082	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965005083	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965005084	ligand binding site [chemical binding]; other site
497965005085	flexible hinge region; other site
497965005086	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
497965005087	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965005088	Walker A motif; other site
497965005089	ATP binding site [chemical binding]; other site
497965005090	Walker B motif; other site
497965005091	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
497965005092	4Fe-4S binding domain; Region: Fer4_5; pfam12801
497965005093	4Fe-4S binding domain; Region: Fer4_5; pfam12801
497965005094	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
497965005095	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965005096	dimer interface [polypeptide binding]; other site
497965005097	conserved gate region; other site
497965005098	ABC-ATPase subunit interface; other site
497965005099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965005100	dimer interface [polypeptide binding]; other site
497965005101	conserved gate region; other site
497965005102	putative PBP binding loops; other site
497965005103	ABC-ATPase subunit interface; other site
497965005104	S-layer homology domain; Region: SLH; pfam00395
497965005105	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
497965005106	S-layer homology domain; Region: SLH; pfam00395
497965005107	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
497965005108	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
497965005109	PhoU domain; Region: PhoU; pfam01895
497965005110	PhoU domain; Region: PhoU; pfam01895
497965005111	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965005112	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965005113	dimer interface [polypeptide binding]; other site
497965005114	phosphorylation site [posttranslational modification]
497965005115	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965005116	ATP binding site [chemical binding]; other site
497965005117	Mg2+ binding site [ion binding]; other site
497965005118	G-X-G motif; other site
497965005119	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965005120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965005121	active site
497965005122	phosphorylation site [posttranslational modification]
497965005123	intermolecular recognition site; other site
497965005124	dimerization interface [polypeptide binding]; other site
497965005125	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965005126	DNA binding site [nucleotide binding]
497965005127	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
497965005128	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
497965005129	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
497965005130	active site
497965005131	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965005132	Predicted membrane protein [Function unknown]; Region: COG2324
497965005133	hydrolase, alpha/beta fold family protein; Region: PLN02824
497965005134	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497965005135	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
497965005136	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965005137	P-loop; other site
497965005138	Magnesium ion binding site [ion binding]; other site
497965005139	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965005140	Magnesium ion binding site [ion binding]; other site
497965005141	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
497965005142	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
497965005143	active site
497965005144	metal binding site [ion binding]; metal-binding site
497965005145	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
497965005146	methionine sulfoxide reductase B; Provisional; Region: PRK00222
497965005147	SelR domain; Region: SelR; pfam01641
497965005148	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
497965005149	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
497965005150	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
497965005151	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965005152	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965005153	Probable transposase; Region: OrfB_IS605; pfam01385
497965005154	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965005155	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
497965005156	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
497965005157	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
497965005158	dimer interface [polypeptide binding]; other site
497965005159	motif 1; other site
497965005160	active site
497965005161	motif 2; other site
497965005162	motif 3; other site
497965005163	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
497965005164	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
497965005165	TPP-binding site [chemical binding]; other site
497965005166	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
497965005167	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
497965005168	PYR/PP interface [polypeptide binding]; other site
497965005169	dimer interface [polypeptide binding]; other site
497965005170	TPP binding site [chemical binding]; other site
497965005171	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
497965005172	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965005173	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
497965005174	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497965005175	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965005176	homodimer interface [polypeptide binding]; other site
497965005177	catalytic residue [active]
497965005178	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965005179	putative active site [active]
497965005180	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
497965005181	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
497965005182	metal-binding site [ion binding]
497965005183	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497965005184	Soluble P-type ATPase [General function prediction only]; Region: COG4087
497965005185	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
497965005186	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
497965005187	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
497965005188	Family of unknown function (DUF490); Region: DUF490; pfam04357
497965005189	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
497965005190	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
497965005191	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
497965005192	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
497965005193	homotrimer interaction site [polypeptide binding]; other site
497965005194	putative active site [active]
497965005195	Uncharacterized conserved protein [Function unknown]; Region: COG0432
497965005196	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
497965005197	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
497965005198	TPR repeat; Region: TPR_11; pfam13414
497965005199	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
497965005200	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
497965005201	putative ligand binding site [chemical binding]; other site
497965005202	Uncharacterized conserved protein [Function unknown]; Region: COG0398
497965005203	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
497965005204	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
497965005205	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965005206	FeS/SAM binding site; other site
497965005207	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
497965005208	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497965005209	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965005210	S-adenosylmethionine binding site [chemical binding]; other site
497965005211	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497965005212	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497965005213	Peptidase family M23; Region: Peptidase_M23; pfam01551
497965005214	homoserine dehydrogenase; Provisional; Region: PRK06349
497965005215	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
497965005216	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
497965005217	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
497965005218	Protein of unknown function (DUF561); Region: DUF561; pfam04481
497965005219	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965005220	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
497965005221	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
497965005222	inhibitor-cofactor binding pocket; inhibition site
497965005223	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965005224	catalytic residue [active]
497965005225	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
497965005226	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
497965005227	Stage II sporulation protein; Region: SpoIID; pfam08486
497965005228	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
497965005229	active site
497965005230	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
497965005231	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
497965005232	active site
497965005233	HIGH motif; other site
497965005234	dimer interface [polypeptide binding]; other site
497965005235	KMSKS motif; other site
497965005236	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965005237	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965005238	active site
497965005239	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965005240	S-adenosylmethionine binding site [chemical binding]; other site
497965005241	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
497965005242	putative active site [active]
497965005243	putative metal binding site [ion binding]; other site
497965005244	FOG: CBS domain [General function prediction only]; Region: COG0517
497965005245	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
497965005246	CP12 domain; Region: CP12; pfam02672
497965005247	DNA gyrase subunit A; Validated; Region: PRK05560
497965005248	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
497965005249	CAP-like domain; other site
497965005250	active site
497965005251	primary dimer interface [polypeptide binding]; other site
497965005252	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497965005253	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497965005254	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497965005255	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497965005256	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497965005257	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497965005258	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965005259	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
497965005260	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
497965005261	active site
497965005262	SAM binding site [chemical binding]; other site
497965005263	homodimer interface [polypeptide binding]; other site
497965005264	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
497965005265	PGAP1-like protein; Region: PGAP1; pfam07819
497965005266	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
497965005267	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
497965005268	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
497965005269	anti sigma factor interaction site; other site
497965005270	regulatory phosphorylation site [posttranslational modification]; other site
497965005271	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
497965005272	Bacterial sugar transferase; Region: Bac_transf; pfam02397
497965005273	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
497965005274	Restriction endonuclease BamHI; Region: BamHI; pfam02923
497965005275	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965005276	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
497965005277	DNA methylase; Region: N6_N4_Mtase; pfam01555
497965005278	Helix-turn-helix domain; Region: HTH_17; pfam12728
497965005279	TROVE domain; Region: TROVE; pfam05731
497965005280	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
497965005281	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
497965005282	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
497965005283	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497965005284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965005285	putative substrate translocation pore; other site
497965005286	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965005287	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347
497965005288	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
497965005289	active site
497965005290	catalytic site [active]
497965005291	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
497965005292	putative lipid kinase; Reviewed; Region: PRK13057
497965005293	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
497965005294	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
497965005295	cyanoexosortase A; Region: cyanoexo_CrtA; TIGR03763
497965005296	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
497965005297	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965005298	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497965005299	putative binding surface; other site
497965005300	active site
497965005301	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965005302	ATP binding site [chemical binding]; other site
497965005303	Mg2+ binding site [ion binding]; other site
497965005304	G-X-G motif; other site
497965005305	Response regulator receiver domain; Region: Response_reg; pfam00072
497965005306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965005307	active site
497965005308	phosphorylation site [posttranslational modification]
497965005309	intermolecular recognition site; other site
497965005310	dimerization interface [polypeptide binding]; other site
497965005311	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
497965005312	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
497965005313	dimer interface [polypeptide binding]; other site
497965005314	putative CheW interface [polypeptide binding]; other site
497965005315	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
497965005316	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
497965005317	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965005318	Response regulator receiver domain; Region: Response_reg; pfam00072
497965005319	active site
497965005320	phosphorylation site [posttranslational modification]
497965005321	intermolecular recognition site; other site
497965005322	dimerization interface [polypeptide binding]; other site
497965005323	Response regulator receiver domain; Region: Response_reg; pfam00072
497965005324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965005325	active site
497965005326	phosphorylation site [posttranslational modification]
497965005327	intermolecular recognition site; other site
497965005328	dimerization interface [polypeptide binding]; other site
497965005329	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
497965005330	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965005331	structural tetrad; other site
497965005332	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
497965005333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965005334	Walker A motif; other site
497965005335	ATP binding site [chemical binding]; other site
497965005336	Walker B motif; other site
497965005337	arginine finger; other site
497965005338	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
497965005339	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
497965005340	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
497965005341	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
497965005342	putative dimer interface [polypeptide binding]; other site
497965005343	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
497965005344	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
497965005345	active site
497965005346	trimer interface [polypeptide binding]; other site
497965005347	allosteric site; other site
497965005348	active site lid [active]
497965005349	hexamer (dimer of trimers) interface [polypeptide binding]; other site
497965005350	agmatinase; Region: agmatinase; TIGR01230
497965005351	Agmatinase-like family; Region: Agmatinase-like; cd09990
497965005352	active site
497965005353	oligomer interface [polypeptide binding]; other site
497965005354	Mn binding site [ion binding]; other site
497965005355	hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100
497965005356	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
497965005357	hydrogenase accessory protein HypB; Region: hypB; TIGR00073
497965005358	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
497965005359	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
497965005360	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497965005361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965005362	dimer interface [polypeptide binding]; other site
497965005363	conserved gate region; other site
497965005364	putative PBP binding loops; other site
497965005365	ABC-ATPase subunit interface; other site
497965005366	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
497965005367	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497965005368	Walker A/P-loop; other site
497965005369	ATP binding site [chemical binding]; other site
497965005370	Q-loop/lid; other site
497965005371	ABC transporter signature motif; other site
497965005372	Walker B; other site
497965005373	D-loop; other site
497965005374	H-loop/switch region; other site
497965005375	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965005376	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
497965005377	P-loop; other site
497965005378	Magnesium ion binding site [ion binding]; other site
497965005379	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965005380	non-specific DNA binding site [nucleotide binding]; other site
497965005381	salt bridge; other site
497965005382	sequence-specific DNA binding site [nucleotide binding]; other site
497965005383	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
497965005384	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
497965005385	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
497965005386	ligand binding site; other site
497965005387	oligomer interface; other site
497965005388	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
497965005389	dimer interface [polypeptide binding]; other site
497965005390	N-terminal domain interface [polypeptide binding]; other site
497965005391	sulfate 1 binding site; other site
497965005392	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
497965005393	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
497965005394	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965005395	catalytic residue [active]
497965005396	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
497965005397	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
497965005398	metal binding site [ion binding]; metal-binding site
497965005399	dimer interface [polypeptide binding]; other site
497965005400	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965005401	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965005402	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965005403	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
497965005404	putative ADP-binding pocket [chemical binding]; other site
497965005405	H+ Antiporter protein; Region: 2A0121; TIGR00900
497965005406	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
497965005407	nucleotide binding region [chemical binding]; other site
497965005408	ATP-binding site [chemical binding]; other site
497965005409	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
497965005410	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
497965005411	ligand binding site [chemical binding]; other site
497965005412	homodimer interface [polypeptide binding]; other site
497965005413	NAD(P) binding site [chemical binding]; other site
497965005414	trimer interface B [polypeptide binding]; other site
497965005415	trimer interface A [polypeptide binding]; other site
497965005416	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
497965005417	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
497965005418	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
497965005419	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965005420	putative active site [active]
497965005421	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
497965005422	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
497965005423	glutathione reductase; Validated; Region: PRK06116
497965005424	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497965005425	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497965005426	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
497965005427	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005428	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005429	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005430	binding surface
497965005431	TPR motif; other site
497965005432	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005433	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005434	binding surface
497965005435	TPR motif; other site
497965005436	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005437	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005438	binding surface
497965005439	TPR motif; other site
497965005440	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005441	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005442	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005443	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005444	binding surface
497965005445	TPR motif; other site
497965005446	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005447	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005448	binding surface
497965005449	TPR motif; other site
497965005450	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005451	Dot/Icm substrate protein; Region: SidE; pfam12252
497965005452	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497965005453	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497965005454	active site
497965005455	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
497965005456	active site
497965005457	oligomerization interface [polypeptide binding]; other site
497965005458	metal binding site [ion binding]; metal-binding site
497965005459	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
497965005460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965005461	S-adenosylmethionine binding site [chemical binding]; other site
497965005462	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
497965005463	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
497965005464	Ycf46; Provisional; Region: ycf46; CHL00195
497965005465	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965005466	Walker A motif; other site
497965005467	ATP binding site [chemical binding]; other site
497965005468	Walker B motif; other site
497965005469	arginine finger; other site
497965005470	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
497965005471	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
497965005472	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
497965005473	Competence protein; Region: Competence; pfam03772
497965005474	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
497965005475	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
497965005476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965005477	S-adenosylmethionine binding site [chemical binding]; other site
497965005478	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965005479	putative active site [active]
497965005480	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965005481	putative active site [active]
497965005482	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
497965005483	Family description; Region: UvrD_C_2; pfam13538
497965005484	Uncharacterized conserved protein (DUF2290); Region: DUF2290; cl02396
497965005485	glycine dehydrogenase; Provisional; Region: PRK05367
497965005486	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
497965005487	tetramer interface [polypeptide binding]; other site
497965005488	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965005489	catalytic residue [active]
497965005490	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
497965005491	tetramer interface [polypeptide binding]; other site
497965005492	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965005493	catalytic residue [active]
497965005494	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965005495	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
497965005496	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
497965005497	putative tRNA-binding site [nucleotide binding]; other site
497965005498	B3/4 domain; Region: B3_4; pfam03483
497965005499	tRNA synthetase B5 domain; Region: B5; smart00874
497965005500	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
497965005501	dimer interface [polypeptide binding]; other site
497965005502	motif 1; other site
497965005503	motif 3; other site
497965005504	motif 2; other site
497965005505	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
497965005506	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
497965005507	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965005508	putative active site [active]
497965005509	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965005510	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965005511	active site
497965005512	ATP binding site [chemical binding]; other site
497965005513	substrate binding site [chemical binding]; other site
497965005514	activation loop (A-loop); other site
497965005515	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965005516	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965005517	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965005518	Protein kinase domain; Region: Pkinase; pfam00069
497965005519	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965005520	active site
497965005521	ATP binding site [chemical binding]; other site
497965005522	substrate binding site [chemical binding]; other site
497965005523	activation loop (A-loop); other site
497965005524	Circadian oscillating protein COP23; Region: COP23; pfam14218
497965005525	Response regulator receiver domain; Region: Response_reg; pfam00072
497965005526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965005527	active site
497965005528	phosphorylation site [posttranslational modification]
497965005529	intermolecular recognition site; other site
497965005530	dimerization interface [polypeptide binding]; other site
497965005531	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
497965005532	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497965005533	active site
497965005534	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
497965005535	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
497965005536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965005537	putative substrate translocation pore; other site
497965005538	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965005539	CsbD-like; Region: CsbD; pfam05532
497965005540	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
497965005541	KH domain; Region: KH_4; pfam13083
497965005542	ribosomal protein S16; Region: rps16; CHL00005
497965005543	BolA-like protein; Region: BolA; pfam01722
497965005544	Predicted transcriptional regulators [Transcription]; Region: COG1725
497965005545	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497965005546	DNA-binding site [nucleotide binding]; DNA binding site
497965005547	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
497965005548	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
497965005549	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
497965005550	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
497965005551	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
497965005552	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
497965005553	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965005554	HSP70 interaction site [polypeptide binding]; other site
497965005555	NB-ARC domain; Region: NB-ARC; pfam00931
497965005556	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005557	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005558	TPR motif; other site
497965005559	binding surface
497965005560	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005561	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005562	binding surface
497965005563	TPR motif; other site
497965005564	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005565	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005566	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005567	binding surface
497965005568	TPR motif; other site
497965005569	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005570	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005571	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005572	binding surface
497965005573	TPR motif; other site
497965005574	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005575	Predicted permeases [General function prediction only]; Region: COG0701
497965005576	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
497965005577	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
497965005578	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497965005579	catalytic core [active]
497965005580	citrate synthase; Provisional; Region: PRK14036
497965005581	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
497965005582	oxalacetate binding site [chemical binding]; other site
497965005583	citrylCoA binding site [chemical binding]; other site
497965005584	coenzyme A binding site [chemical binding]; other site
497965005585	catalytic triad [active]
497965005586	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965005587	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965005588	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965005589	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965005590	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965005591	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965005592	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
497965005593	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
497965005594	dimer interface [polypeptide binding]; other site
497965005595	putative CheW interface [polypeptide binding]; other site
497965005596	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
497965005597	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
497965005598	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
497965005599	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
497965005600	active site
497965005601	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
497965005602	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
497965005603	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
497965005604	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
497965005605	HAMP domain; Region: HAMP; pfam00672
497965005606	dimerization interface [polypeptide binding]; other site
497965005607	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965005608	dimer interface [polypeptide binding]; other site
497965005609	phosphorylation site [posttranslational modification]
497965005610	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965005611	ATP binding site [chemical binding]; other site
497965005612	Mg2+ binding site [ion binding]; other site
497965005613	G-X-G motif; other site
497965005614	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965005615	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
497965005616	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497965005617	Walker A/P-loop; other site
497965005618	ATP binding site [chemical binding]; other site
497965005619	Q-loop/lid; other site
497965005620	ABC transporter signature motif; other site
497965005621	Walker B; other site
497965005622	D-loop; other site
497965005623	H-loop/switch region; other site
497965005624	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497965005625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965005626	dimer interface [polypeptide binding]; other site
497965005627	conserved gate region; other site
497965005628	putative PBP binding loops; other site
497965005629	ABC-ATPase subunit interface; other site
497965005630	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
497965005631	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
497965005632	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
497965005633	Sulfate transporter family; Region: Sulfate_transp; pfam00916
497965005634	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
497965005635	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965005636	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965005637	ligand binding site [chemical binding]; other site
497965005638	flexible hinge region; other site
497965005639	Cupin domain; Region: Cupin_2; cl17218
497965005640	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
497965005641	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
497965005642	S17 interaction site [polypeptide binding]; other site
497965005643	S8 interaction site; other site
497965005644	16S rRNA interaction site [nucleotide binding]; other site
497965005645	streptomycin interaction site [chemical binding]; other site
497965005646	23S rRNA interaction site [nucleotide binding]; other site
497965005647	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
497965005648	30S ribosomal protein S7; Validated; Region: PRK05302
497965005649	elongation factor G; Reviewed; Region: PRK00007
497965005650	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
497965005651	G1 box; other site
497965005652	putative GEF interaction site [polypeptide binding]; other site
497965005653	GTP/Mg2+ binding site [chemical binding]; other site
497965005654	Switch I region; other site
497965005655	G2 box; other site
497965005656	G3 box; other site
497965005657	Switch II region; other site
497965005658	G4 box; other site
497965005659	G5 box; other site
497965005660	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
497965005661	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
497965005662	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
497965005663	elongation factor Tu; Region: tufA; CHL00071
497965005664	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
497965005665	G1 box; other site
497965005666	GEF interaction site [polypeptide binding]; other site
497965005667	GTP/Mg2+ binding site [chemical binding]; other site
497965005668	Switch I region; other site
497965005669	G2 box; other site
497965005670	G3 box; other site
497965005671	Switch II region; other site
497965005672	G4 box; other site
497965005673	G5 box; other site
497965005674	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
497965005675	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
497965005676	Antibiotic Binding Site [chemical binding]; other site
497965005677	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
497965005678	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
497965005679	prephenate dehydratase; Provisional; Region: PRK11898
497965005680	Prephenate dehydratase; Region: PDT; pfam00800
497965005681	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
497965005682	putative L-Phe binding site [chemical binding]; other site
497965005683	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
497965005684	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
497965005685	RNA/DNA hybrid binding site [nucleotide binding]; other site
497965005686	active site
497965005687	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
497965005688	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
497965005689	homodimer interface [polypeptide binding]; other site
497965005690	oligonucleotide binding site [chemical binding]; other site
497965005691	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
497965005692	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
497965005693	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497965005694	catalytic residue [active]
497965005695	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
497965005696	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
497965005697	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
497965005698	Sporulation related domain; Region: SPOR; pfam05036
497965005699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965005700	active site
497965005701	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965005702	phosphorylation site [posttranslational modification]
497965005703	intermolecular recognition site; other site
497965005704	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965005705	dimer interface [polypeptide binding]; other site
497965005706	phosphorylation site [posttranslational modification]
497965005707	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965005708	ATP binding site [chemical binding]; other site
497965005709	Mg2+ binding site [ion binding]; other site
497965005710	G-X-G motif; other site
497965005711	Response regulator receiver domain; Region: Response_reg; pfam00072
497965005712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965005713	active site
497965005714	phosphorylation site [posttranslational modification]
497965005715	intermolecular recognition site; other site
497965005716	dimerization interface [polypeptide binding]; other site
497965005717	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
497965005718	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965005719	Phytochrome region; Region: PHY; pfam00360
497965005720	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
497965005721	dimer interface [polypeptide binding]; other site
497965005722	phosphorylation site [posttranslational modification]
497965005723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965005724	ATP binding site [chemical binding]; other site
497965005725	Mg2+ binding site [ion binding]; other site
497965005726	G-X-G motif; other site
497965005727	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
497965005728	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965005729	ATP binding site [chemical binding]; other site
497965005730	putative Mg++ binding site [ion binding]; other site
497965005731	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
497965005732	Ras GTPase Activating Domain; Region: RasGAP; cl02569
497965005733	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965005734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965005735	active site
497965005736	phosphorylation site [posttranslational modification]
497965005737	intermolecular recognition site; other site
497965005738	dimerization interface [polypeptide binding]; other site
497965005739	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965005740	DNA binding residues [nucleotide binding]
497965005741	dimerization interface [polypeptide binding]; other site
497965005742	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
497965005743	Low molecular weight phosphatase family; Region: LMWPc; cd00115
497965005744	active site
497965005745	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
497965005746	oxyanion hole [active]
497965005747	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965005748	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965005749	phosphopeptide binding site; other site
497965005750	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965005751	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
497965005752	feedback inhibition sensing region; other site
497965005753	homohexameric interface [polypeptide binding]; other site
497965005754	nucleotide binding site [chemical binding]; other site
497965005755	N-acetyl-L-glutamate binding site [chemical binding]; other site
497965005756	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
497965005757	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
497965005758	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
497965005759	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
497965005760	active site
497965005761	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965005762	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965005763	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965005764	active site
497965005765	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965005766	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
497965005767	Probable Catalytic site; other site
497965005768	metal-binding site
497965005769	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
497965005770	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
497965005771	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
497965005772	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
497965005773	Ligand binding site; other site
497965005774	Putative Catalytic site; other site
497965005775	DXD motif; other site
497965005776	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
497965005777	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
497965005778	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
497965005779	Probable Catalytic site; other site
497965005780	metal-binding site
497965005781	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965005782	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
497965005783	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
497965005784	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965005785	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
497965005786	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965005787	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
497965005788	protein binding site [polypeptide binding]; other site
497965005789	carotene isomerase; Region: carot_isom; TIGR02730
497965005790	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965005791	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965005792	GAF domain; Region: GAF; pfam01590
497965005793	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965005794	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965005795	dimer interface [polypeptide binding]; other site
497965005796	phosphorylation site [posttranslational modification]
497965005797	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965005798	Mg2+ binding site [ion binding]; other site
497965005799	G-X-G motif; other site
497965005800	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
497965005801	ABC1 family; Region: ABC1; cl17513
497965005802	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
497965005803	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
497965005804	cofactor binding site; other site
497965005805	DNA binding site [nucleotide binding]
497965005806	substrate interaction site [chemical binding]; other site
497965005807	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
497965005808	dimer interface [polypeptide binding]; other site
497965005809	catalytic triad [active]
497965005810	TPR repeat; Region: TPR_11; pfam13414
497965005811	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005812	binding surface
497965005813	TPR motif; other site
497965005814	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005815	binding surface
497965005816	TPR motif; other site
497965005817	TPR repeat; Region: TPR_11; pfam13414
497965005818	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
497965005819	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497965005820	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497965005821	Response regulator receiver domain; Region: Response_reg; pfam00072
497965005822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965005823	active site
497965005824	phosphorylation site [posttranslational modification]
497965005825	intermolecular recognition site; other site
497965005826	dimerization interface [polypeptide binding]; other site
497965005827	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965005828	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965005829	metal binding site [ion binding]; metal-binding site
497965005830	active site
497965005831	I-site; other site
497965005832	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005834	binding surface
497965005835	TPR motif; other site
497965005836	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005837	Tetratricopeptide repeat; Region: TPR_10; pfam13374
497965005838	Tetratricopeptide repeat; Region: TPR_10; cl17452
497965005839	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005840	Tetratricopeptide repeat; Region: TPR_10; cl17452
497965005841	Tetratricopeptide repeat; Region: TPR_10; cl17452
497965005842	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
497965005843	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
497965005844	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
497965005845	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965005846	Walker A motif; other site
497965005847	ATP binding site [chemical binding]; other site
497965005848	Walker B motif; other site
497965005849	Drosophila melanogaster CG11883 and related proteins, N-terminal metallophosphatase domain; Region: MPP_CG11883_N; cd07406
497965005850	putative active site [active]
497965005851	putative metal binding site [ion binding]; other site
497965005852	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
497965005853	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
497965005854	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
497965005855	Glutaminase; Region: Glutaminase; cl00907
497965005856	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
497965005857	putative ADP-ribose binding site [chemical binding]; other site
497965005858	putative active site [active]
497965005859	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497965005860	Ligand Binding Site [chemical binding]; other site
497965005861	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497965005862	Ligand Binding Site [chemical binding]; other site
497965005863	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
497965005864	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
497965005865	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497965005866	catalytic loop [active]
497965005867	iron binding site [ion binding]; other site
497965005868	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
497965005869	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
497965005870	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
497965005871	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
497965005872	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
497965005873	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
497965005874	trimer interface [polypeptide binding]; other site
497965005875	active site
497965005876	UDP-GlcNAc binding site [chemical binding]; other site
497965005877	lipid binding site [chemical binding]; lipid-binding site
497965005878	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965005879	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965005880	Probable transposase; Region: OrfB_IS605; pfam01385
497965005881	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965005882	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965005883	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965005884	structural tetrad; other site
497965005885	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965005886	HSP70 interaction site [polypeptide binding]; other site
497965005887	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
497965005888	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
497965005889	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
497965005890	Pyruvate formate lyase 1; Region: PFL1; cd01678
497965005891	coenzyme A binding site [chemical binding]; other site
497965005892	active site
497965005893	catalytic residues [active]
497965005894	glycine loop; other site
497965005895	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
497965005896	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965005897	FeS/SAM binding site; other site
497965005898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965005899	S-adenosylmethionine binding site [chemical binding]; other site
497965005900	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
497965005901	intersubunit interface [polypeptide binding]; other site
497965005902	active site
497965005903	catalytic residue [active]
497965005904	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
497965005905	Recombination protein O N terminal; Region: RecO_N; pfam11967
497965005906	Recombination protein O C terminal; Region: RecO_C; pfam02565
497965005907	H+ Antiporter protein; Region: 2A0121; TIGR00900
497965005908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965005909	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965005910	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965005911	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
497965005912	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
497965005913	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
497965005914	TrkA-N domain; Region: TrkA_N; pfam02254
497965005915	TrkA-C domain; Region: TrkA_C; pfam02080
497965005916	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497965005917	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
497965005918	active site
497965005919	metal binding site [ion binding]; metal-binding site
497965005920	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
497965005921	ligand-binding site [chemical binding]; other site
497965005922	RNA polymerase sigma factor; Validated; Region: PRK05949
497965005923	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
497965005924	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965005925	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
497965005926	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965005927	DNA binding residues [nucleotide binding]
497965005928	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
497965005929	ribosomal protein S14; Region: rps14; CHL00074
497965005930	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
497965005931	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
497965005932	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
497965005933	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965005934	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
497965005935	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965005936	DNA binding residues [nucleotide binding]
497965005937	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
497965005938	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005939	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005940	binding surface
497965005941	TPR motif; other site
497965005942	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005943	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005944	binding surface
497965005945	TPR motif; other site
497965005946	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005947	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005948	binding surface
497965005949	TPR motif; other site
497965005950	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005951	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005952	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005953	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005954	binding surface
497965005955	TPR motif; other site
497965005956	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005957	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965005958	binding surface
497965005959	TPR motif; other site
497965005960	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965005961	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
497965005962	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
497965005963	dimer interface [polypeptide binding]; other site
497965005964	tetramer interface [polypeptide binding]; other site
497965005965	PYR/PP interface [polypeptide binding]; other site
497965005966	TPP binding site [chemical binding]; other site
497965005967	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
497965005968	TPP-binding site; other site
497965005969	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
497965005970	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
497965005971	MutS domain I; Region: MutS_I; pfam01624
497965005972	MutS domain II; Region: MutS_II; pfam05188
497965005973	MutS domain III; Region: MutS_III; pfam05192
497965005974	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
497965005975	Walker A/P-loop; other site
497965005976	ATP binding site [chemical binding]; other site
497965005977	Q-loop/lid; other site
497965005978	ABC transporter signature motif; other site
497965005979	Walker B; other site
497965005980	D-loop; other site
497965005981	H-loop/switch region; other site
497965005982	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
497965005983	active site
497965005984	hypothetical protein; Provisional; Region: PRK06184
497965005985	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
497965005986	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
497965005987	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
497965005988	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
497965005989	active site residue [active]
497965005990	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
497965005991	active site residue [active]
497965005992	putative inner membrane protein; Provisional; Region: PRK11099
497965005993	putative inner membrane protein; Provisional; Region: PRK11099
497965005994	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
497965005995	putative hexamer interface [polypeptide binding]; other site
497965005996	putative hexagonal pore; other site
497965005997	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
497965005998	Hexamer interface [polypeptide binding]; other site
497965005999	Hexagonal pore residue; other site
497965006000	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
497965006001	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
497965006002	ribosomal protein L33; Region: rpl33; CHL00104
497965006003	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
497965006004	PemK-like protein; Region: PemK; cl00995
497965006005	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
497965006006	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
497965006007	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
497965006008	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
497965006009	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
497965006010	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
497965006011	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
497965006012	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
497965006013	putative active site [active]
497965006014	putative metal binding residues [ion binding]; other site
497965006015	signature motif; other site
497965006016	putative dimer interface [polypeptide binding]; other site
497965006017	putative phosphate binding site [ion binding]; other site
497965006018	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965006019	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965006020	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965006021	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965006022	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965006023	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
497965006024	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
497965006025	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
497965006026	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965006027	putative active site [active]
497965006028	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965006029	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965006030	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965006031	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965006032	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
497965006033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965006034	putative substrate translocation pore; other site
497965006035	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965006036	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
497965006037	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
497965006038	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965006039	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497965006040	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497965006041	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
497965006042	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
497965006043	nucleotide binding site [chemical binding]; other site
497965006044	putative NEF/HSP70 interaction site [polypeptide binding]; other site
497965006045	SBD interface [polypeptide binding]; other site
497965006046	Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_3; cd04327
497965006047	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
497965006048	active site
497965006049	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
497965006050	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
497965006051	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
497965006052	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
497965006053	LabA_like proteins; Region: LabA_like; cd06167
497965006054	putative metal binding site [ion binding]; other site
497965006055	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
497965006056	Predicted ATPase [General function prediction only]; Region: COG4637
497965006057	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965006058	Walker A/P-loop; other site
497965006059	ATP binding site [chemical binding]; other site
497965006060	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965006061	ABC transporter signature motif; other site
497965006062	Walker B; other site
497965006063	D-loop; other site
497965006064	H-loop/switch region; other site
497965006065	Domain of unknown function DUF11; Region: DUF11; cl17728
497965006066	Hemerythrin-like domain; Region: Hr-like; cd12108
497965006067	Predicted membrane protein [Function unknown]; Region: COG4244
497965006068	ribosome recycling factor; Reviewed; Region: frr; PRK00083
497965006069	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
497965006070	hinge region; other site
497965006071	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
497965006072	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
497965006073	Walker A/P-loop; other site
497965006074	ATP binding site [chemical binding]; other site
497965006075	Q-loop/lid; other site
497965006076	ABC transporter signature motif; other site
497965006077	Walker B; other site
497965006078	D-loop; other site
497965006079	H-loop/switch region; other site
497965006080	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
497965006081	Walker A/P-loop; other site
497965006082	ATP binding site [chemical binding]; other site
497965006083	Q-loop/lid; other site
497965006084	ABC transporter signature motif; other site
497965006085	Walker B; other site
497965006086	D-loop; other site
497965006087	H-loop/switch region; other site
497965006088	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
497965006089	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
497965006090	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
497965006091	active site
497965006092	TDP-binding site; other site
497965006093	acceptor substrate-binding pocket; other site
497965006094	homodimer interface [polypeptide binding]; other site
497965006095	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
497965006096	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
497965006097	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
497965006098	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
497965006099	C-terminal domain interface [polypeptide binding]; other site
497965006100	active site
497965006101	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
497965006102	active site
497965006103	N-terminal domain interface [polypeptide binding]; other site
497965006104	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
497965006105	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
497965006106	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497965006107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965006108	S-adenosylmethionine binding site [chemical binding]; other site
497965006109	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
497965006110	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
497965006111	NAD binding site [chemical binding]; other site
497965006112	dimerization interface [polypeptide binding]; other site
497965006113	product binding site; other site
497965006114	substrate binding site [chemical binding]; other site
497965006115	zinc binding site [ion binding]; other site
497965006116	catalytic residues [active]
497965006117	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
497965006118	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
497965006119	TPR repeat; Region: TPR_11; pfam13414
497965006120	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965006121	binding surface
497965006122	TPR motif; other site
497965006123	TPR repeat; Region: TPR_11; pfam13414
497965006124	amino acid transporter; Region: 2A0306; TIGR00909
497965006125	Response regulator receiver domain; Region: Response_reg; pfam00072
497965006126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965006127	active site
497965006128	phosphorylation site [posttranslational modification]
497965006129	intermolecular recognition site; other site
497965006130	dimerization interface [polypeptide binding]; other site
497965006131	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965006132	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965006133	metal binding site [ion binding]; metal-binding site
497965006134	active site
497965006135	I-site; other site
497965006136	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
497965006137	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497965006138	substrate binding pocket [chemical binding]; other site
497965006139	membrane-bound complex binding site; other site
497965006140	hinge residues; other site
497965006141	TPR repeat; Region: TPR_11; pfam13414
497965006142	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965006143	binding surface
497965006144	TPR motif; other site
497965006145	TPR repeat; Region: TPR_11; pfam13414
497965006146	Beta-lactamase; Region: Beta-lactamase; pfam00144
497965006147	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
497965006148	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
497965006149	Family description; Region: UvrD_C_2; pfam13538
497965006150	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965006151	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965006152	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965006153	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965006154	putative active site [active]
497965006155	Transposase IS200 like; Region: Y1_Tnp; pfam01797
497965006156	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965006157	active site
497965006158	ATP binding site [chemical binding]; other site
497965006159	substrate binding site [chemical binding]; other site
497965006160	activation loop (A-loop); other site
497965006161	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
497965006162	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
497965006163	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
497965006164	TPP-binding site [chemical binding]; other site
497965006165	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
497965006166	Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600
497965006167	aspartate kinase; Provisional; Region: PRK07431
497965006168	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
497965006169	putative catalytic residues [active]
497965006170	putative nucleotide binding site [chemical binding]; other site
497965006171	putative aspartate binding site [chemical binding]; other site
497965006172	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
497965006173	putative allosteric regulatory site; other site
497965006174	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
497965006175	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
497965006176	putative allosteric regulatory site; other site
497965006177	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
497965006178	putative allosteric regulatory residue; other site
497965006179	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
497965006180	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
497965006181	active site
497965006182	metal binding site [ion binding]; metal-binding site
497965006183	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
497965006184	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
497965006185	active site
497965006186	dimerization interface [polypeptide binding]; other site
497965006187	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
497965006188	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
497965006189	active site
497965006190	catalytic tetrad [active]
497965006191	thiamine monophosphate kinase; Provisional; Region: PRK05731
497965006192	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
497965006193	ATP binding site [chemical binding]; other site
497965006194	dimerization interface [polypeptide binding]; other site
497965006195	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
497965006196	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
497965006197	homodimer interface [polypeptide binding]; other site
497965006198	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
497965006199	active site pocket [active]
497965006200	Uncharacterized conserved protein [Function unknown]; Region: COG2947
497965006201	Sporulation and spore germination; Region: Germane; pfam10646
497965006202	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
497965006203	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
497965006204	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
497965006205	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
497965006206	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
497965006207	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
497965006208	active site
497965006209	NTP binding site [chemical binding]; other site
497965006210	metal binding triad [ion binding]; metal-binding site
497965006211	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
497965006212	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
497965006213	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
497965006214	putative substrate binding pocket [chemical binding]; other site
497965006215	catalytic triad [active]
497965006216	AB domain interface; other site
497965006217	Origin recognition complex, subunit 2 [DNA replication, recombination, and repair]; Region: ORC2; COG5575
497965006218	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
497965006219	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
497965006220	dimer interface [polypeptide binding]; other site
497965006221	motif 1; other site
497965006222	active site
497965006223	motif 2; other site
497965006224	motif 3; other site
497965006225	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
497965006226	anticodon binding site; other site
497965006227	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965006228	dimer interface [polypeptide binding]; other site
497965006229	phosphorylation site [posttranslational modification]
497965006230	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965006231	ATP binding site [chemical binding]; other site
497965006232	Mg2+ binding site [ion binding]; other site
497965006233	G-X-G motif; other site
497965006234	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965006235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965006236	active site
497965006237	phosphorylation site [posttranslational modification]
497965006238	intermolecular recognition site; other site
497965006239	dimerization interface [polypeptide binding]; other site
497965006240	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965006241	DNA binding site [nucleotide binding]
497965006242	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
497965006243	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965006244	hypothetical protein; Provisional; Region: PRK11281
497965006245	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
497965006246	dimer interface [polypeptide binding]; other site
497965006247	substrate binding site [chemical binding]; other site
497965006248	ATP binding site [chemical binding]; other site
497965006249	cell division protein FtsZ; Region: ftsZ; TIGR00065
497965006250	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
497965006251	nucleotide binding site [chemical binding]; other site
497965006252	SulA interaction site; other site
497965006253	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
497965006254	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
497965006255	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
497965006256	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
497965006257	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
497965006258	protein binding site [polypeptide binding]; other site
497965006259	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
497965006260	Catalytic dyad [active]
497965006261	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
497965006262	tetramer interface [polypeptide binding]; other site
497965006263	dimer interface [polypeptide binding]; other site
497965006264	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
497965006265	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
497965006266	Walker A motif; other site
497965006267	ATP binding site [chemical binding]; other site
497965006268	Walker B motif; other site
497965006269	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
497965006270	homodimer interface [polypeptide binding]; other site
497965006271	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
497965006272	active site pocket [active]
497965006273	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
497965006274	OstA-like protein; Region: OstA; cl00844
497965006275	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
497965006276	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965006277	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
497965006278	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
497965006279	iron-sulfur cluster [ion binding]; other site
497965006280	[2Fe-2S] cluster binding site [ion binding]; other site
497965006281	Uncharacterized conserved protein [Function unknown]; Region: COG3349
497965006282	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
497965006283	pyrroline-5-carboxylate reductase; Region: PLN02688
497965006284	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
497965006285	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
497965006286	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
497965006287	catalytic residue [active]
497965006288	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
497965006289	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
497965006290	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497965006291	dimer interface [polypeptide binding]; other site
497965006292	putative metal binding site [ion binding]; other site
497965006293	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
497965006294	Resolvase, N terminal domain; Region: Resolvase; smart00857
497965006295	Recombinase; Region: Recombinase; pfam07508
497965006296	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
497965006297	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930
497965006298	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
497965006299	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
497965006300	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
497965006301	nucleoside/Zn binding site; other site
497965006302	dimer interface [polypeptide binding]; other site
497965006303	catalytic motif [active]
497965006304	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
497965006305	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
497965006306	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965006307	non-specific DNA binding site [nucleotide binding]; other site
497965006308	salt bridge; other site
497965006309	sequence-specific DNA binding site [nucleotide binding]; other site
497965006310	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
497965006311	putative nucleotide binding site [chemical binding]; other site
497965006312	uridine monophosphate binding site [chemical binding]; other site
497965006313	homohexameric interface [polypeptide binding]; other site
497965006314	agmatinase; Region: agmatinase; TIGR01230
497965006315	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
497965006316	putative active site [active]
497965006317	Mn binding site [ion binding]; other site
497965006318	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
497965006319	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
497965006320	cofactor binding site; other site
497965006321	DNA binding site [nucleotide binding]
497965006322	substrate interaction site [chemical binding]; other site
497965006323	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
497965006324	catalytic triad [active]
497965006325	conserved cis-peptide bond; other site
497965006326	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
497965006327	GAF domain; Region: GAF; cl17456
497965006328	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965006329	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965006330	dimer interface [polypeptide binding]; other site
497965006331	phosphorylation site [posttranslational modification]
497965006332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965006333	ATP binding site [chemical binding]; other site
497965006334	Mg2+ binding site [ion binding]; other site
497965006335	G-X-G motif; other site
497965006336	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
497965006337	Predicted membrane protein [Function unknown]; Region: COG2259
497965006338	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
497965006339	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
497965006340	substrate binding site [chemical binding]; other site
497965006341	active site
497965006342	catalytic residues [active]
497965006343	heterodimer interface [polypeptide binding]; other site
497965006344	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
497965006345	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
497965006346	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
497965006347	nudix motif; other site
497965006348	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
497965006349	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
497965006350	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
497965006351	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
497965006352	putative hydrophobic ligand binding site [chemical binding]; other site
497965006353	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
497965006354	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
497965006355	NAD binding site [chemical binding]; other site
497965006356	catalytic Zn binding site [ion binding]; other site
497965006357	structural Zn binding site [ion binding]; other site
497965006358	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
497965006359	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
497965006360	NAD binding site [chemical binding]; other site
497965006361	catalytic Zn binding site [ion binding]; other site
497965006362	structural Zn binding site [ion binding]; other site
497965006363	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
497965006364	Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205
497965006365	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
497965006366	Uncharacterized protein conserved in archaea (DUF2193); Region: DUF2193; cl02034
497965006367	Response regulator receiver domain; Region: Response_reg; pfam00072
497965006368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965006369	active site
497965006370	phosphorylation site [posttranslational modification]
497965006371	intermolecular recognition site; other site
497965006372	dimerization interface [polypeptide binding]; other site
497965006373	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965006374	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
497965006375	dimanganese center [ion binding]; other site
497965006376	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
497965006377	DNA polymerase III subunit beta; Validated; Region: PRK05643
497965006378	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
497965006379	putative DNA binding surface [nucleotide binding]; other site
497965006380	dimer interface [polypeptide binding]; other site
497965006381	beta-clamp/clamp loader binding surface; other site
497965006382	beta-clamp/translesion DNA polymerase binding surface; other site
497965006383	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
497965006384	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
497965006385	putative ligand binding site [chemical binding]; other site
497965006386	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965006387	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965006388	active site
497965006389	ATP binding site [chemical binding]; other site
497965006390	substrate binding site [chemical binding]; other site
497965006391	activation loop (A-loop); other site
497965006392	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
497965006393	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497965006394	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
497965006395	putative dimerization interface [polypeptide binding]; other site
497965006396	Predicted membrane protein [Function unknown]; Region: COG4094
497965006397	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
497965006398	catalytic residues [active]
497965006399	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
497965006400	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
497965006401	putative acyl-acceptor binding pocket; other site
497965006402	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
497965006403	active site
497965006404	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
497965006405	Nitrogen regulatory protein P-II; Region: P-II; smart00938
497965006406	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
497965006407	intracellular protease, PfpI family; Region: PfpI; TIGR01382
497965006408	proposed catalytic triad [active]
497965006409	conserved cys residue [active]
497965006410	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
497965006411	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
497965006412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965006413	S-adenosylmethionine binding site [chemical binding]; other site
497965006414	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
497965006415	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
497965006416	active site
497965006417	motif I; other site
497965006418	motif II; other site
497965006419	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965006420	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965006421	putative active site [active]
497965006422	heme pocket [chemical binding]; other site
497965006423	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965006424	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965006425	dimer interface [polypeptide binding]; other site
497965006426	phosphorylation site [posttranslational modification]
497965006427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965006428	ATP binding site [chemical binding]; other site
497965006429	Mg2+ binding site [ion binding]; other site
497965006430	G-X-G motif; other site
497965006431	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965006432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965006433	active site
497965006434	phosphorylation site [posttranslational modification]
497965006435	intermolecular recognition site; other site
497965006436	dimerization interface [polypeptide binding]; other site
497965006437	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497965006438	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497965006439	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497965006440	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
497965006441	arogenate dehydrogenase; Region: PLN02256
497965006442	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
497965006443	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
497965006444	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
497965006445	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
497965006446	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
497965006447	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
497965006448	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
497965006449	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965006450	catalytic residue [active]
497965006451	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
497965006452	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
497965006453	substrate binding site [chemical binding]; other site
497965006454	active site
497965006455	catalytic residues [active]
497965006456	heterodimer interface [polypeptide binding]; other site
497965006457	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
497965006458	active site
497965006459	ribulose/triose binding site [chemical binding]; other site
497965006460	phosphate binding site [ion binding]; other site
497965006461	substrate (anthranilate) binding pocket [chemical binding]; other site
497965006462	product (indole) binding pocket [chemical binding]; other site
497965006463	anthranilate synthase; Provisional; Region: PRK13566
497965006464	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
497965006465	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
497965006466	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
497965006467	glutamine binding [chemical binding]; other site
497965006468	catalytic triad [active]
497965006469	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
497965006470	trimer interface [polypeptide binding]; other site
497965006471	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
497965006472	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
497965006473	PYR/PP interface [polypeptide binding]; other site
497965006474	dimer interface [polypeptide binding]; other site
497965006475	TPP binding site [chemical binding]; other site
497965006476	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
497965006477	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
497965006478	TPP-binding site [chemical binding]; other site
497965006479	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
497965006480	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
497965006481	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
497965006482	NAD binding site [chemical binding]; other site
497965006483	Phe binding site; other site
497965006484	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
497965006485	Uncharacterized conserved protein [Function unknown]; Region: COG3391
497965006486	NHL repeat; Region: NHL; pfam01436
497965006487	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
497965006488	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
497965006489	active site
497965006490	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
497965006491	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
497965006492	Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198
497965006493	active site
497965006494	metal binding site [ion binding]; metal-binding site
497965006495	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
497965006496	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
497965006497	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
497965006498	four helix bundle protein; Region: TIGR02436
497965006499	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
497965006500	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965006501	Walker A/P-loop; other site
497965006502	ATP binding site [chemical binding]; other site
497965006503	Q-loop/lid; other site
497965006504	ABC transporter signature motif; other site
497965006505	Walker B; other site
497965006506	D-loop; other site
497965006507	H-loop/switch region; other site
497965006508	TOBE domain; Region: TOBE_2; pfam08402
497965006509	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
497965006510	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
497965006511	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
497965006512	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
497965006513	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
497965006514	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
497965006515	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
497965006516	Predicted flavoprotein [General function prediction only]; Region: COG0431
497965006517	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
497965006518	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
497965006519	30S subunit binding site; other site
497965006520	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
497965006521	DNA-binding site [nucleotide binding]; DNA binding site
497965006522	RNA-binding motif; other site
497965006523	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
497965006524	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
497965006525	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
497965006526	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
497965006527	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965006528	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
497965006529	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
497965006530	active site
497965006531	catalytic tetrad [active]
497965006532	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
497965006533	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
497965006534	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
497965006535	putative dimer interface [polypeptide binding]; other site
497965006536	N-terminal domain interface [polypeptide binding]; other site
497965006537	putative substrate binding pocket (H-site) [chemical binding]; other site
497965006538	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
497965006539	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
497965006540	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
497965006541	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
497965006542	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
497965006543	PUCC protein; Region: PUCC; pfam03209
497965006544	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
497965006545	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
497965006546	active site
497965006547	metal binding site [ion binding]; metal-binding site
497965006548	DNA binding site [nucleotide binding]
497965006549	HEAT repeats; Region: HEAT_2; pfam13646
497965006550	HEAT repeats; Region: HEAT_2; pfam13646
497965006551	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965006552	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965006553	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965006554	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965006555	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
497965006556	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
497965006557	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
497965006558	Zn binding site [ion binding]; other site
497965006559	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
497965006560	geranylgeranyl reductase; Region: ChlP; TIGR02028
497965006561	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497965006562	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
497965006563	FtsH Extracellular; Region: FtsH_ext; pfam06480
497965006564	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
497965006565	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965006566	Walker A motif; other site
497965006567	ATP binding site [chemical binding]; other site
497965006568	Walker B motif; other site
497965006569	arginine finger; other site
497965006570	Peptidase family M41; Region: Peptidase_M41; pfam01434
497965006571	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
497965006572	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
497965006573	glycogen binding site [chemical binding]; other site
497965006574	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
497965006575	active site
497965006576	catalytic site [active]
497965006577	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
497965006578	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
497965006579	malate synthase A; Region: malate_syn_A; TIGR01344
497965006580	active site
497965006581	isocitrate lyase; Provisional; Region: PRK15063
497965006582	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
497965006583	tetramer interface [polypeptide binding]; other site
497965006584	active site
497965006585	Mg2+/Mn2+ binding site [ion binding]; other site
497965006586	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
497965006587	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
497965006588	active site
497965006589	dimer interface [polypeptide binding]; other site
497965006590	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965006591	binding surface
497965006592	TPR motif; other site
497965006593	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965006594	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965006595	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965006596	binding surface
497965006597	TPR motif; other site
497965006598	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965006599	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965006600	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965006601	binding surface
497965006602	TPR motif; other site
497965006603	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
497965006604	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965006605	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965006606	structural tetrad; other site
497965006607	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
497965006608	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
497965006609	DNA binding residues [nucleotide binding]
497965006610	dimer interface [polypeptide binding]; other site
497965006611	metal binding site [ion binding]; metal-binding site
497965006612	light-harvesting-like protein 3; Provisional; Region: PLN00014
497965006613	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
497965006614	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
497965006615	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965006616	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
497965006617	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965006618	DNA binding residues [nucleotide binding]
497965006619	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
497965006620	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
497965006621	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
497965006622	putative active site [active]
497965006623	putative NTP binding site [chemical binding]; other site
497965006624	putative nucleic acid binding site [nucleotide binding]; other site
497965006625	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
497965006626	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965006627	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965006628	active site
497965006629	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497965006630	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497965006631	glyoxylate reductase; Reviewed; Region: PRK13243
497965006632	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
497965006633	dimerization interface [polypeptide binding]; other site
497965006634	ligand binding site [chemical binding]; other site
497965006635	NADP binding site [chemical binding]; other site
497965006636	catalytic site [active]
497965006637	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965006638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965006639	active site
497965006640	phosphorylation site [posttranslational modification]
497965006641	intermolecular recognition site; other site
497965006642	dimerization interface [polypeptide binding]; other site
497965006643	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965006644	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965006645	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965006646	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965006647	metal binding site [ion binding]; metal-binding site
497965006648	active site
497965006649	I-site; other site
497965006650	TPR repeat; Region: TPR_11; pfam13414
497965006651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965006652	binding surface
497965006653	TPR motif; other site
497965006654	TPR repeat; Region: TPR_11; pfam13414
497965006655	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
497965006656	G1 box; other site
497965006657	GTP/Mg2+ binding site [chemical binding]; other site
497965006658	G2 box; other site
497965006659	Switch I region; other site
497965006660	G3 box; other site
497965006661	Switch II region; other site
497965006662	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
497965006663	FAD binding domain; Region: FAD_binding_4; pfam01565
497965006664	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
497965006665	CARDB; Region: CARDB; pfam07705
497965006666	CARDB; Region: CARDB; pfam07705
497965006667	CARDB; Region: CARDB; pfam07705
497965006668	CARDB; Region: CARDB; pfam07705
497965006669	CARDB; Region: CARDB; pfam07705
497965006670	CARDB; Region: CARDB; pfam07705
497965006671	CARDB; Region: CARDB; pfam07705
497965006672	CARDB; Region: CARDB; pfam07705
497965006673	CARDB; Region: CARDB; pfam07705
497965006674	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
497965006675	catalytic site [active]
497965006676	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
497965006677	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
497965006678	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
497965006679	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
497965006680	Coenzyme A binding pocket [chemical binding]; other site
497965006681	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
497965006682	phosphoglucomutase; Validated; Region: PRK07564
497965006683	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
497965006684	active site
497965006685	substrate binding site [chemical binding]; other site
497965006686	metal binding site [ion binding]; metal-binding site
497965006687	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
497965006688	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
497965006689	putative homodimer interface [polypeptide binding]; other site
497965006690	putative homotetramer interface [polypeptide binding]; other site
497965006691	putative metal binding site [ion binding]; other site
497965006692	putative homodimer-homodimer interface [polypeptide binding]; other site
497965006693	putative allosteric switch controlling residues; other site
497965006694	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
497965006695	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
497965006696	catalytic site [active]
497965006697	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
497965006698	active site
497965006699	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965006700	Calx-beta domain; Region: Calx-beta; pfam03160
497965006701	Calx-beta domain; Region: Calx-beta; pfam03160
497965006702	Calx-beta domain; Region: Calx-beta; pfam03160
497965006703	TrkA-N domain; Region: TrkA_N; pfam02254
497965006704	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
497965006705	TrkA-N domain; Region: TrkA_N; pfam02254
497965006706	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
497965006707	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
497965006708	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965006709	PAS domain; Region: PAS_9; pfam13426
497965006710	putative active site [active]
497965006711	heme pocket [chemical binding]; other site
497965006712	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965006713	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965006714	metal binding site [ion binding]; metal-binding site
497965006715	active site
497965006716	I-site; other site
497965006717	dephospho-CoA kinase; Region: TIGR00152
497965006718	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
497965006719	CoA-binding site [chemical binding]; other site
497965006720	ATP-binding [chemical binding]; other site
497965006721	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
497965006722	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
497965006723	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
497965006724	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
497965006725	Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187
497965006726	Uncharacterized conserved protein [Function unknown]; Region: COG1262
497965006727	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
497965006728	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
497965006729	Sulfatase; Region: Sulfatase; pfam00884
497965006730	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497965006731	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497965006732	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
497965006733	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
497965006734	transmembrane helices; other site
497965006735	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
497965006736	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
497965006737	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497965006738	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
497965006739	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
497965006740	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
497965006741	Stage II sporulation protein; Region: SpoIID; pfam08486
497965006742	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
497965006743	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
497965006744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965006745	ATP binding site [chemical binding]; other site
497965006746	Mg2+ binding site [ion binding]; other site
497965006747	G-X-G motif; other site
497965006748	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
497965006749	Response regulator receiver domain; Region: Response_reg; pfam00072
497965006750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965006751	active site
497965006752	phosphorylation site [posttranslational modification]
497965006753	intermolecular recognition site; other site
497965006754	dimerization interface [polypeptide binding]; other site
497965006755	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965006756	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965006757	active site
497965006758	phosphorylation site [posttranslational modification]
497965006759	intermolecular recognition site; other site
497965006760	dimerization interface [polypeptide binding]; other site
497965006761	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
497965006762	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
497965006763	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
497965006764	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
497965006765	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
497965006766	Walker A/P-loop; other site
497965006767	ATP binding site [chemical binding]; other site
497965006768	Q-loop/lid; other site
497965006769	ABC transporter signature motif; other site
497965006770	Walker B; other site
497965006771	D-loop; other site
497965006772	H-loop/switch region; other site
497965006773	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965006774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965006775	active site
497965006776	phosphorylation site [posttranslational modification]
497965006777	intermolecular recognition site; other site
497965006778	dimerization interface [polypeptide binding]; other site
497965006779	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965006780	DNA binding site [nucleotide binding]
497965006781	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
497965006782	putative GSH binding site [chemical binding]; other site
497965006783	catalytic residues [active]
497965006784	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
497965006785	LVIVD repeat; Region: LVIVD; pfam08309
497965006786	LVIVD repeat; Region: LVIVD; pfam08309
497965006787	LVIVD repeat; Region: LVIVD; pfam08309
497965006788	LVIVD repeat; Region: LVIVD; pfam08309
497965006789	LVIVD repeat; Region: LVIVD; pfam08309
497965006790	LVIVD repeat; Region: LVIVD; pfam08309
497965006791	LVIVD repeat; Region: LVIVD; pfam08309
497965006792	LVIVD repeat; Region: LVIVD; pfam08309
497965006793	LVIVD repeat; Region: LVIVD; pfam08309
497965006794	LVIVD repeat; Region: LVIVD; pfam08309
497965006795	Calx-beta domain; Region: Calx-beta; cl02522
497965006796	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965006797	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
497965006798	NADH dehydrogenase; Region: NADHdh; cl00469
497965006799	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
497965006800	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
497965006801	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
497965006802	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
497965006803	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
497965006804	NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015
497965006805	Tubulin like; Region: Tubulin_2; pfam13809
497965006806	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
497965006807	Double zinc ribbon; Region: DZR; pfam12773
497965006808	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965006809	PAS fold; Region: PAS_3; pfam08447
497965006810	putative active site [active]
497965006811	heme pocket [chemical binding]; other site
497965006812	PAS domain S-box; Region: sensory_box; TIGR00229
497965006813	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965006814	putative active site [active]
497965006815	heme pocket [chemical binding]; other site
497965006816	PAS domain S-box; Region: sensory_box; TIGR00229
497965006817	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965006818	putative active site [active]
497965006819	heme pocket [chemical binding]; other site
497965006820	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965006821	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965006822	putative active site [active]
497965006823	heme pocket [chemical binding]; other site
497965006824	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965006825	dimer interface [polypeptide binding]; other site
497965006826	phosphorylation site [posttranslational modification]
497965006827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965006828	ATP binding site [chemical binding]; other site
497965006829	Mg2+ binding site [ion binding]; other site
497965006830	G-X-G motif; other site
497965006831	Response regulator receiver domain; Region: Response_reg; pfam00072
497965006832	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965006833	active site
497965006834	phosphorylation site [posttranslational modification]
497965006835	intermolecular recognition site; other site
497965006836	dimerization interface [polypeptide binding]; other site
497965006837	Response regulator receiver domain; Region: Response_reg; pfam00072
497965006838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965006839	active site
497965006840	phosphorylation site [posttranslational modification]
497965006841	intermolecular recognition site; other site
497965006842	dimerization interface [polypeptide binding]; other site
497965006843	PAS fold; Region: PAS_4; pfam08448
497965006844	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965006845	putative active site [active]
497965006846	heme pocket [chemical binding]; other site
497965006847	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965006848	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965006849	metal binding site [ion binding]; metal-binding site
497965006850	active site
497965006851	I-site; other site
497965006852	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965006853	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
497965006854	GAF domain; Region: GAF; pfam01590
497965006855	Phytochrome region; Region: PHY; pfam00360
497965006856	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965006857	dimer interface [polypeptide binding]; other site
497965006858	phosphorylation site [posttranslational modification]
497965006859	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965006860	ATP binding site [chemical binding]; other site
497965006861	Mg2+ binding site [ion binding]; other site
497965006862	G-X-G motif; other site
497965006863	Response regulator receiver domain; Region: Response_reg; pfam00072
497965006864	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965006865	active site
497965006866	phosphorylation site [posttranslational modification]
497965006867	intermolecular recognition site; other site
497965006868	dimerization interface [polypeptide binding]; other site
497965006869	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
497965006870	metal ion-dependent adhesion site (MIDAS); other site
497965006871	TPR repeat; Region: TPR_11; pfam13414
497965006872	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
497965006873	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
497965006874	putative ligand binding site [chemical binding]; other site
497965006875	Iron permease FTR1 family; Region: FTR1; cl00475
497965006876	Ferritin-like domain; Region: Ferritin; pfam00210
497965006877	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
497965006878	dinuclear metal binding motif [ion binding]; other site
497965006879	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
497965006880	CpeS-like protein; Region: CpeS; pfam09367
497965006881	ribonuclease Y; Region: RNase_Y; TIGR03319
497965006882	Caspase domain; Region: Peptidase_C14; pfam00656
497965006883	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965006884	Walker A/P-loop; other site
497965006885	ATP binding site [chemical binding]; other site
497965006886	WD domain, G-beta repeat; Region: WD40; pfam00400
497965006887	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965006888	structural tetrad; other site
497965006889	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965006890	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965006891	structural tetrad; other site
497965006892	flavoprotein, HI0933 family; Region: TIGR00275
497965006893	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497965006894	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
497965006895	Phycobilisome protein; Region: Phycobilisome; cl08227
497965006896	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
497965006897	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497965006898	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497965006899	phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418
497965006900	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
497965006901	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
497965006902	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
497965006903	Uncharacterized conserved protein [Function unknown]; Region: COG3391
497965006904	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
497965006905	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
497965006906	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965006907	dimerization interface [polypeptide binding]; other site
497965006908	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965006909	ATP binding site [chemical binding]; other site
497965006910	Mg2+ binding site [ion binding]; other site
497965006911	G-X-G motif; other site
497965006912	PAS fold; Region: PAS_4; pfam08448
497965006913	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965006914	GAF domain; Region: GAF_3; pfam13492
497965006915	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965006916	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965006917	dimer interface [polypeptide binding]; other site
497965006918	phosphorylation site [posttranslational modification]
497965006919	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965006920	ATP binding site [chemical binding]; other site
497965006921	Mg2+ binding site [ion binding]; other site
497965006922	G-X-G motif; other site
497965006923	Response regulator receiver domain; Region: Response_reg; pfam00072
497965006924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965006925	active site
497965006926	phosphorylation site [posttranslational modification]
497965006927	intermolecular recognition site; other site
497965006928	dimerization interface [polypeptide binding]; other site
497965006929	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965006930	PAS domain; Region: PAS_9; pfam13426
497965006931	putative active site [active]
497965006932	heme pocket [chemical binding]; other site
497965006933	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965006934	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965006935	putative active site [active]
497965006936	heme pocket [chemical binding]; other site
497965006937	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965006938	dimer interface [polypeptide binding]; other site
497965006939	phosphorylation site [posttranslational modification]
497965006940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965006941	ATP binding site [chemical binding]; other site
497965006942	Mg2+ binding site [ion binding]; other site
497965006943	G-X-G motif; other site
497965006944	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
497965006945	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
497965006946	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
497965006947	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
497965006948	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
497965006949	NodB motif; other site
497965006950	active site
497965006951	catalytic site [active]
497965006952	metal binding site [ion binding]; metal-binding site
497965006953	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
497965006954	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965006955	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
497965006956	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965006957	DNA binding residues [nucleotide binding]
497965006958	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
497965006959	putative metal binding site; other site
497965006960	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965006961	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965006962	binding surface
497965006963	TPR motif; other site
497965006964	TPR repeat; Region: TPR_11; pfam13414
497965006965	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965006966	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965006967	binding surface
497965006968	TPR motif; other site
497965006969	UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186
497965006970	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
497965006971	ABC1 family; Region: ABC1; cl17513
497965006972	ABC1 family; Region: ABC1; cl17513
497965006973	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
497965006974	active site
497965006975	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
497965006976	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497965006977	substrate binding pocket [chemical binding]; other site
497965006978	membrane-bound complex binding site; other site
497965006979	hinge residues; other site
497965006980	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
497965006981	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965006982	conserved gate region; other site
497965006983	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965006984	putative PBP binding loops; other site
497965006985	dimer interface [polypeptide binding]; other site
497965006986	ABC-ATPase subunit interface; other site
497965006987	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965006988	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965006989	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
497965006990	Protein of unknown function DUF99; Region: DUF99; cl00704
497965006991	hypothetical protein; Provisional; Region: PRK00766
497965006992	Protein of unknown function DUF99; Region: DUF99; pfam01949
497965006993	methionine sulfoxide reductase B; Provisional; Region: PRK00222
497965006994	SelR domain; Region: SelR; pfam01641
497965006995	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
497965006996	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965006997	glycogen synthase; Provisional; Region: glgA; PRK00654
497965006998	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
497965006999	ADP-binding pocket [chemical binding]; other site
497965007000	homodimer interface [polypeptide binding]; other site
497965007001	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965007002	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965007003	structural tetrad; other site
497965007004	WD40 repeats; Region: WD40; smart00320
497965007005	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965007006	structural tetrad; other site
497965007007	PQQ-like domain; Region: PQQ_2; pfam13360
497965007008	dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361
497965007009	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
497965007010	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965007011	FeS/SAM binding site; other site
497965007012	HemN C-terminal domain; Region: HemN_C; pfam06969
497965007013	Ion channel; Region: Ion_trans_2; pfam07885
497965007014	ribonuclease E; Reviewed; Region: rne; PRK10811
497965007015	Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865
497965007016	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
497965007017	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
497965007018	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497965007019	putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828
497965007020	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965007021	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965007022	Probable transposase; Region: OrfB_IS605; pfam01385
497965007023	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965007024	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
497965007025	Domain of unknown function DUF21; Region: DUF21; pfam01595
497965007026	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
497965007027	Transporter associated domain; Region: CorC_HlyC; smart01091
497965007028	GAF domain; Region: GAF_3; pfam13492
497965007029	Response regulator receiver domain; Region: Response_reg; pfam00072
497965007030	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965007031	active site
497965007032	phosphorylation site [posttranslational modification]
497965007033	intermolecular recognition site; other site
497965007034	dimerization interface [polypeptide binding]; other site
497965007035	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965007036	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965007037	putative active site [active]
497965007038	heme pocket [chemical binding]; other site
497965007039	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965007040	putative active site [active]
497965007041	heme pocket [chemical binding]; other site
497965007042	PAS fold; Region: PAS_4; pfam08448
497965007043	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965007044	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
497965007045	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965007046	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965007047	putative active site [active]
497965007048	heme pocket [chemical binding]; other site
497965007049	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965007050	dimer interface [polypeptide binding]; other site
497965007051	phosphorylation site [posttranslational modification]
497965007052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965007053	ATP binding site [chemical binding]; other site
497965007054	Mg2+ binding site [ion binding]; other site
497965007055	G-X-G motif; other site
497965007056	Response regulator receiver domain; Region: Response_reg; pfam00072
497965007057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965007058	active site
497965007059	phosphorylation site [posttranslational modification]
497965007060	intermolecular recognition site; other site
497965007061	dimerization interface [polypeptide binding]; other site
497965007062	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
497965007063	NMT1-like family; Region: NMT1_2; pfam13379
497965007064	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
497965007065	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965007066	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
497965007067	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
497965007068	MutS domain III; Region: MutS_III; pfam05192
497965007069	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965007070	Walker A/P-loop; other site
497965007071	ATP binding site [chemical binding]; other site
497965007072	Q-loop/lid; other site
497965007073	ABC transporter signature motif; other site
497965007074	Walker B; other site
497965007075	D-loop; other site
497965007076	H-loop/switch region; other site
497965007077	Smr domain; Region: Smr; pfam01713
497965007078	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
497965007079	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
497965007080	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
497965007081	generic binding surface I; other site
497965007082	generic binding surface II; other site
497965007083	Transposase; Region: DEDD_Tnp_IS110; pfam01548
497965007084	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
497965007085	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965007086	non-specific DNA binding site [nucleotide binding]; other site
497965007087	salt bridge; other site
497965007088	sequence-specific DNA binding site [nucleotide binding]; other site
497965007089	enoyl-CoA hydratase; Provisional; Region: PRK06072
497965007090	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965007091	active site
497965007092	catalytic residues [active]
497965007093	DNA binding site [nucleotide binding]
497965007094	Int/Topo IB signature motif; other site
497965007095	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
497965007096	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
497965007097	Integral membrane protein DUF92; Region: DUF92; pfam01940
497965007098	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
497965007099	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965007100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965007101	PAS domain; Region: PAS_9; pfam13426
497965007102	putative active site [active]
497965007103	heme pocket [chemical binding]; other site
497965007104	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965007105	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965007106	metal binding site [ion binding]; metal-binding site
497965007107	active site
497965007108	I-site; other site
497965007109	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965007110	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
497965007111	ATP-binding site [chemical binding]; other site
497965007112	Gluconate-6-phosphate binding site [chemical binding]; other site
497965007113	Shikimate kinase; Region: SKI; pfam01202
497965007114	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
497965007115	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
497965007116	acyl-activating enzyme (AAE) consensus motif; other site
497965007117	putative AMP binding site [chemical binding]; other site
497965007118	putative active site [active]
497965007119	putative CoA binding site [chemical binding]; other site
497965007120	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965007121	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965007122	active site
497965007123	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
497965007124	WD domain, G-beta repeat; Region: WD40; pfam00400
497965007125	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965007126	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965007127	structural tetrad; other site
497965007128	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965007129	structural tetrad; other site
497965007130	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
497965007131	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
497965007132	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
497965007133	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
497965007134	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
497965007135	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
497965007136	Domain of unknown function DUF20; Region: UPF0118; pfam01594
497965007137	Predicted integral membrane protein [Function unknown]; Region: COG0762
497965007138	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
497965007139	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
497965007140	putative active site [active]
497965007141	putative metal binding site [ion binding]; other site
497965007142	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
497965007143	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
497965007144	oligomer interface [polypeptide binding]; other site
497965007145	active site residues [active]
497965007146	Clp protease; Region: CLP_protease; pfam00574
497965007147	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
497965007148	oligomer interface [polypeptide binding]; other site
497965007149	active site residues [active]
497965007150	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965007151	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965007152	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965007153	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965007154	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
497965007155	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
497965007156	active site
497965007157	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
497965007158	proline aminopeptidase P II; Provisional; Region: PRK10879
497965007159	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
497965007160	active site
497965007161	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
497965007162	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
497965007163	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
497965007164	ChaB; Region: ChaB; pfam06150
497965007165	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
497965007166	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
497965007167	dimerization interface [polypeptide binding]; other site
497965007168	DPS ferroxidase diiron center [ion binding]; other site
497965007169	ion pore; other site
497965007170	short chain dehydrogenase; Provisional; Region: PRK07109
497965007171	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
497965007172	putative NAD(P) binding site [chemical binding]; other site
497965007173	active site
497965007174	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965007175	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965007176	active site
497965007177	ATP binding site [chemical binding]; other site
497965007178	substrate binding site [chemical binding]; other site
497965007179	activation loop (A-loop); other site
497965007180	RDD family; Region: RDD; pfam06271
497965007181	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
497965007182	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
497965007183	DXD motif; other site
497965007184	Cellulose synthase-like protein; Region: PLN02893
497965007185	PilZ domain; Region: PilZ; pfam07238
497965007186	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
497965007187	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
497965007188	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965007189	Walker A motif; other site
497965007190	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
497965007191	protein-splicing catalytic site; other site
497965007192	thioester formation/cholesterol transfer; other site
497965007193	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
497965007194	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
497965007195	protein-splicing catalytic site; other site
497965007196	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965007197	ATP binding site [chemical binding]; other site
497965007198	Walker B motif; other site
497965007199	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
497965007200	protein-splicing catalytic site; other site
497965007201	thioester formation/cholesterol transfer; other site
497965007202	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965007203	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965007204	non-specific DNA binding site [nucleotide binding]; other site
497965007205	salt bridge; other site
497965007206	sequence-specific DNA binding site [nucleotide binding]; other site
497965007207	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
497965007208	RNA/DNA hybrid binding site [nucleotide binding]; other site
497965007209	active site
497965007210	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497965007211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965007212	S-adenosylmethionine binding site [chemical binding]; other site
497965007213	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
497965007214	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
497965007215	RNA binding site [nucleotide binding]; other site
497965007216	active site
497965007217	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
497965007218	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965007219	PAS fold; Region: PAS_3; pfam08447
497965007220	putative active site [active]
497965007221	heme pocket [chemical binding]; other site
497965007222	PAS fold; Region: PAS_4; pfam08448
497965007223	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965007224	putative active site [active]
497965007225	heme pocket [chemical binding]; other site
497965007226	PAS fold; Region: PAS_4; pfam08448
497965007227	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965007228	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965007229	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965007230	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965007231	dimer interface [polypeptide binding]; other site
497965007232	phosphorylation site [posttranslational modification]
497965007233	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965007234	ATP binding site [chemical binding]; other site
497965007235	Mg2+ binding site [ion binding]; other site
497965007236	G-X-G motif; other site
497965007237	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
497965007238	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965007239	binding surface
497965007240	TPR motif; other site
497965007241	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965007242	binding surface
497965007243	TPR motif; other site
497965007244	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965007245	binding surface
497965007246	TPR motif; other site
497965007247	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965007248	binding surface
497965007249	TPR motif; other site
497965007250	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
497965007251	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965007252	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
497965007253	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965007254	active site
497965007255	motif I; other site
497965007256	motif II; other site
497965007257	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
497965007258	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
497965007259	putative active site [active]
497965007260	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
497965007261	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
497965007262	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
497965007263	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
497965007264	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
497965007265	homotrimer interaction site [polypeptide binding]; other site
497965007266	putative active site [active]
497965007267	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
497965007268	classical (c) SDRs; Region: SDR_c; cd05233
497965007269	NAD(P) binding site [chemical binding]; other site
497965007270	active site
497965007271	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497965007272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965007273	S-adenosylmethionine binding site [chemical binding]; other site
497965007274	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965007275	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965007276	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
497965007277	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
497965007278	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497965007279	Peptidase family M23; Region: Peptidase_M23; pfam01551
497965007280	precorrin-8X methylmutase; Provisional; Region: PRK05954
497965007281	Precorrin-8X methylmutase; Region: CbiC; pfam02570
497965007282	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
497965007283	active site
497965007284	putative homodimer interface [polypeptide binding]; other site
497965007285	SAM binding site [chemical binding]; other site
497965007286	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
497965007287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965007288	S-adenosylmethionine binding site [chemical binding]; other site
497965007289	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
497965007290	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
497965007291	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965007292	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497965007293	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965007294	Photosystem II protein Y (PsbY); Region: PsbY; pfam06298
497965007295	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
497965007296	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
497965007297	trimer interface [polypeptide binding]; other site
497965007298	putative metal binding site [ion binding]; other site
497965007299	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
497965007300	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497965007301	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
497965007302	active site
497965007303	metal binding site [ion binding]; metal-binding site
497965007304	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
497965007305	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
497965007306	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
497965007307	alpha-gamma subunit interface [polypeptide binding]; other site
497965007308	beta-gamma subunit interface [polypeptide binding]; other site
497965007309	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
497965007310	gamma-beta subunit interface [polypeptide binding]; other site
497965007311	alpha-beta subunit interface [polypeptide binding]; other site
497965007312	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497965007313	UreD urease accessory protein; Region: UreD; pfam01774
497965007314	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727
497965007315	dimer interface [polypeptide binding]; other site
497965007316	catalytic residues [active]
497965007317	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
497965007318	UreF; Region: UreF; pfam01730
497965007319	urease subunit alpha; Reviewed; Region: ureC; PRK13207
497965007320	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
497965007321	subunit interactions [polypeptide binding]; other site
497965007322	active site
497965007323	flap region; other site
497965007324	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
497965007325	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
497965007326	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
497965007327	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965007328	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965007329	ligand binding site [chemical binding]; other site
497965007330	flexible hinge region; other site
497965007331	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
497965007332	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
497965007333	putative active site [active]
497965007334	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497965007335	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965007336	Walker A/P-loop; other site
497965007337	ATP binding site [chemical binding]; other site
497965007338	Q-loop/lid; other site
497965007339	ABC transporter signature motif; other site
497965007340	Walker B; other site
497965007341	D-loop; other site
497965007342	H-loop/switch region; other site
497965007343	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
497965007344	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
497965007345	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
497965007346	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965007347	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
497965007348	protein binding site [polypeptide binding]; other site
497965007349	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
497965007350	CAAX protease self-immunity; Region: Abi; pfam02517
497965007351	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
497965007352	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
497965007353	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
497965007354	ATP-grasp domain; Region: ATP-grasp_4; cl17255
497965007355	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965007356	Divergent PAP2 family; Region: DUF212; pfam02681
497965007357	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
497965007358	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
497965007359	substrate binding pocket [chemical binding]; other site
497965007360	chain length determination region; other site
497965007361	substrate-Mg2+ binding site; other site
497965007362	catalytic residues [active]
497965007363	aspartate-rich region 1; other site
497965007364	active site lid residues [active]
497965007365	aspartate-rich region 2; other site
497965007366	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
497965007367	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
497965007368	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
497965007369	peripheral dimer interface [polypeptide binding]; other site
497965007370	core dimer interface [polypeptide binding]; other site
497965007371	L10 interface [polypeptide binding]; other site
497965007372	L11 interface [polypeptide binding]; other site
497965007373	putative EF-Tu interaction site [polypeptide binding]; other site
497965007374	putative EF-G interaction site [polypeptide binding]; other site
497965007375	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
497965007376	23S rRNA interface [nucleotide binding]; other site
497965007377	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
497965007378	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
497965007379	mRNA/rRNA interface [nucleotide binding]; other site
497965007380	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
497965007381	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
497965007382	23S rRNA interface [nucleotide binding]; other site
497965007383	L7/L12 interface [polypeptide binding]; other site
497965007384	putative thiostrepton binding site; other site
497965007385	L25 interface [polypeptide binding]; other site
497965007386	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
497965007387	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
497965007388	putative homodimer interface [polypeptide binding]; other site
497965007389	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
497965007390	heterodimer interface [polypeptide binding]; other site
497965007391	homodimer interface [polypeptide binding]; other site
497965007392	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
497965007393	ribosomal protein L19; Region: rpl19; CHL00084
497965007394	Integral membrane protein TerC family; Region: TerC; cl10468
497965007395	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965007396	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965007397	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965007398	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965007399	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965007400	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965007401	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965007402	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965007403	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
497965007404	Protein export membrane protein; Region: SecD_SecF; pfam02355
497965007405	protein-export membrane protein SecD; Region: secD; TIGR01129
497965007406	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
497965007407	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
497965007408	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
497965007409	alpha subunit interface [polypeptide binding]; other site
497965007410	TPP binding site [chemical binding]; other site
497965007411	heterodimer interface [polypeptide binding]; other site
497965007412	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
497965007413	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
497965007414	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
497965007415	MOSC domain; Region: MOSC; pfam03473
497965007416	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
497965007417	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965007418	ATP binding site [chemical binding]; other site
497965007419	putative Mg++ binding site [ion binding]; other site
497965007420	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965007421	nucleotide binding region [chemical binding]; other site
497965007422	ATP-binding site [chemical binding]; other site
497965007423	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
497965007424	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965007425	Circadian oscillating protein COP23; Region: COP23; pfam14218
497965007426	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
497965007427	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
497965007428	putative phosphate acyltransferase; Provisional; Region: PRK05331
497965007429	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
497965007430	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
497965007431	dimer interface [polypeptide binding]; other site
497965007432	active site
497965007433	CoA binding pocket [chemical binding]; other site
497965007434	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
497965007435	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
497965007436	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
497965007437	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
497965007438	putative NAD(P) binding site [chemical binding]; other site
497965007439	active site
497965007440	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
497965007441	Part of AAA domain; Region: AAA_19; pfam13245
497965007442	Family description; Region: UvrD_C_2; pfam13538
497965007443	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965007444	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
497965007445	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
497965007446	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
497965007447	homodimer interface [polypeptide binding]; other site
497965007448	Walker A motif; other site
497965007449	ATP binding site [chemical binding]; other site
497965007450	hydroxycobalamin binding site [chemical binding]; other site
497965007451	Walker B motif; other site
497965007452	short chain dehydrogenase; Provisional; Region: PRK06701
497965007453	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
497965007454	NAD binding site [chemical binding]; other site
497965007455	metal binding site [ion binding]; metal-binding site
497965007456	active site
497965007457	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
497965007458	Fasciclin domain; Region: Fasciclin; pfam02469
497965007459	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
497965007460	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
497965007461	catalytic triad [active]
497965007462	DNA primase; Validated; Region: dnaG; PRK05667
497965007463	FeoA domain; Region: FeoA; pfam04023
497965007464	S-layer homology domain; Region: SLH; pfam00395
497965007465	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
497965007466	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
497965007467	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
497965007468	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
497965007469	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
497965007470	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965007471	Probable transposase; Region: OrfB_IS605; pfam01385
497965007472	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965007473	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965007474	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965007475	Probable transposase; Region: OrfB_IS605; pfam01385
497965007476	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965007477	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
497965007478	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
497965007479	active site
497965007480	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
497965007481	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
497965007482	anti sigma factor interaction site; other site
497965007483	regulatory phosphorylation site [posttranslational modification]; other site
497965007484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
497965007485	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
497965007486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965007487	active site
497965007488	phosphorylation site [posttranslational modification]
497965007489	intermolecular recognition site; other site
497965007490	CheB methylesterase; Region: CheB_methylest; pfam01339
497965007491	Response regulator receiver domain; Region: Response_reg; pfam00072
497965007492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965007493	active site
497965007494	phosphorylation site [posttranslational modification]
497965007495	intermolecular recognition site; other site
497965007496	dimerization interface [polypeptide binding]; other site
497965007497	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
497965007498	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
497965007499	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
497965007500	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
497965007501	cofactor binding site; other site
497965007502	DNA binding site [nucleotide binding]
497965007503	substrate interaction site [chemical binding]; other site
497965007504	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
497965007505	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497965007506	putative binding surface; other site
497965007507	active site
497965007508	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
497965007509	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965007510	ATP binding site [chemical binding]; other site
497965007511	Mg2+ binding site [ion binding]; other site
497965007512	G-X-G motif; other site
497965007513	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
497965007514	Response regulator receiver domain; Region: Response_reg; pfam00072
497965007515	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965007516	active site
497965007517	phosphorylation site [posttranslational modification]
497965007518	intermolecular recognition site; other site
497965007519	dimerization interface [polypeptide binding]; other site
497965007520	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
497965007521	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
497965007522	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
497965007523	[2Fe-2S] cluster binding site [ion binding]; other site
497965007524	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
497965007525	alpha subunit interface [polypeptide binding]; other site
497965007526	active site
497965007527	substrate binding site [chemical binding]; other site
497965007528	Fe binding site [ion binding]; other site
497965007529	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
497965007530	Part of AAA domain; Region: AAA_19; pfam13245
497965007531	Family description; Region: UvrD_C_2; pfam13538
497965007532	Predicted membrane protein [Function unknown]; Region: COG3463
497965007533	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
497965007534	Uncharacterized small conserved protein [Function unknown]; Region: COG5626
497965007535	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
497965007536	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
497965007537	oligomer interface [polypeptide binding]; other site
497965007538	metal binding site [ion binding]; metal-binding site
497965007539	metal binding site [ion binding]; metal-binding site
497965007540	Cl binding site [ion binding]; other site
497965007541	aspartate ring; other site
497965007542	basic sphincter; other site
497965007543	putative hydrophobic gate; other site
497965007544	periplasmic entrance; other site
497965007545	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
497965007546	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965007547	dimer interface [polypeptide binding]; other site
497965007548	conserved gate region; other site
497965007549	putative PBP binding loops; other site
497965007550	ABC-ATPase subunit interface; other site
497965007551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965007552	ABC-ATPase subunit interface; other site
497965007553	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
497965007554	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497965007555	Walker A/P-loop; other site
497965007556	ATP binding site [chemical binding]; other site
497965007557	Q-loop/lid; other site
497965007558	ABC transporter signature motif; other site
497965007559	Walker B; other site
497965007560	D-loop; other site
497965007561	H-loop/switch region; other site
497965007562	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
497965007563	ornithine carbamoyltransferase; Provisional; Region: PRK00779
497965007564	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
497965007565	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
497965007566	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
497965007567	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
497965007568	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
497965007569	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
497965007570	putative dimer interface [polypeptide binding]; other site
497965007571	putative anticodon binding site; other site
497965007572	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
497965007573	homodimer interface [polypeptide binding]; other site
497965007574	motif 1; other site
497965007575	motif 2; other site
497965007576	active site
497965007577	motif 3; other site
497965007578	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
497965007579	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
497965007580	putative active site [active]
497965007581	substrate binding site [chemical binding]; other site
497965007582	putative cosubstrate binding site; other site
497965007583	catalytic site [active]
497965007584	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
497965007585	Cobalt transport protein; Region: CbiQ; pfam02361
497965007586	GTP-binding protein Der; Reviewed; Region: PRK00093
497965007587	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
497965007588	G1 box; other site
497965007589	GTP/Mg2+ binding site [chemical binding]; other site
497965007590	Switch I region; other site
497965007591	G2 box; other site
497965007592	Switch II region; other site
497965007593	G3 box; other site
497965007594	G4 box; other site
497965007595	G5 box; other site
497965007596	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
497965007597	G1 box; other site
497965007598	GTP/Mg2+ binding site [chemical binding]; other site
497965007599	Switch I region; other site
497965007600	G2 box; other site
497965007601	G3 box; other site
497965007602	Switch II region; other site
497965007603	G4 box; other site
497965007604	G5 box; other site
497965007605	YCII-related domain; Region: YCII; cl00999
497965007606	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
497965007607	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
497965007608	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
497965007609	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
497965007610	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
497965007611	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
497965007612	active site residue [active]
497965007613	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
497965007614	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
497965007615	G-X-X-G motif; other site
497965007616	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
497965007617	RxxxH motif; other site
497965007618	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
497965007619	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
497965007620	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
497965007621	Bacterial PH domain; Region: DUF304; pfam03703
497965007622	ribonuclease P; Reviewed; Region: rnpA; PRK03031
497965007623	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
497965007624	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
497965007625	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
497965007626	motif 1; other site
497965007627	active site
497965007628	motif 2; other site
497965007629	motif 3; other site
497965007630	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
497965007631	DHHA1 domain; Region: DHHA1; pfam02272
497965007632	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
497965007633	RloB-like protein; Region: RloB; pfam13707
497965007634	AAA domain; Region: AAA_21; pfam13304
497965007635	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965007636	Walker B; other site
497965007637	D-loop; other site
497965007638	H-loop/switch region; other site
497965007639	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
497965007640	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
497965007641	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
497965007642	putative active site [active]
497965007643	putative NTP binding site [chemical binding]; other site
497965007644	putative nucleic acid binding site [nucleotide binding]; other site
497965007645	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
497965007646	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965007647	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965007648	active site
497965007649	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
497965007650	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
497965007651	MAPEG family; Region: MAPEG; pfam01124
497965007652	Cytochrome c; Region: Cytochrom_C; cl11414
497965007653	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
497965007654	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
497965007655	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
497965007656	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
497965007657	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
497965007658	Walker A/P-loop; other site
497965007659	ATP binding site [chemical binding]; other site
497965007660	Q-loop/lid; other site
497965007661	ABC transporter signature motif; other site
497965007662	Walker B; other site
497965007663	D-loop; other site
497965007664	H-loop/switch region; other site
497965007665	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965007666	TPR motif; other site
497965007667	binding surface
497965007668	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
497965007669	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
497965007670	proposed catalytic triad [active]
497965007671	active site nucleophile [active]
497965007672	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
497965007673	ATP-grasp domain; Region: ATP-grasp_4; cl17255
497965007674	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
497965007675	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
497965007676	PemK-like protein; Region: PemK; pfam02452
497965007677	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
497965007678	DEAD/DEAH box helicase; Region: DEAD; pfam00270
497965007679	putative Mg++ binding site [ion binding]; other site
497965007680	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
497965007681	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
497965007682	inhibitor-cofactor binding pocket; inhibition site
497965007683	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965007684	catalytic residue [active]
497965007685	fumarate hydratase; Reviewed; Region: fumC; PRK00485
497965007686	Class II fumarases; Region: Fumarase_classII; cd01362
497965007687	active site
497965007688	tetramer interface [polypeptide binding]; other site
497965007689	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
497965007690	dimer interface [polypeptide binding]; other site
497965007691	FMN binding site [chemical binding]; other site
497965007692	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965007693	putative active site [active]
497965007694	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
497965007695	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
497965007696	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
497965007697	metal binding site [ion binding]; metal-binding site
497965007698	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
497965007699	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
497965007700	TrkA-N domain; Region: TrkA_N; pfam02254
497965007701	TrkA-C domain; Region: TrkA_C; pfam02080
497965007702	TrkA-C domain; Region: TrkA_C; pfam02080
497965007703	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
497965007704	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
497965007705	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
497965007706	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
497965007707	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965007708	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
497965007709	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
497965007710	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
497965007711	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
497965007712	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965007713	GAF domain; Region: GAF; pfam01590
497965007714	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965007715	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965007716	dimer interface [polypeptide binding]; other site
497965007717	phosphorylation site [posttranslational modification]
497965007718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965007719	ATP binding site [chemical binding]; other site
497965007720	Mg2+ binding site [ion binding]; other site
497965007721	G-X-G motif; other site
497965007722	Response regulator receiver domain; Region: Response_reg; pfam00072
497965007723	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965007724	active site
497965007725	phosphorylation site [posttranslational modification]
497965007726	intermolecular recognition site; other site
497965007727	dimerization interface [polypeptide binding]; other site
497965007728	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
497965007729	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
497965007730	putative valine binding site [chemical binding]; other site
497965007731	dimer interface [polypeptide binding]; other site
497965007732	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
497965007733	Tic22-like family; Region: Tic22; pfam04278
497965007734	Tic22-like family; Region: Tic22; cl04468
497965007735	Tic22-like family; Region: Tic22; cl04468
497965007736	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
497965007737	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965007738	Coenzyme A binding pocket [chemical binding]; other site
497965007739	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965007740	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
497965007741	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
497965007742	NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180
497965007743	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
497965007744	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
497965007745	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
497965007746	TrkA-N domain; Region: TrkA_N; pfam02254
497965007747	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
497965007748	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
497965007749	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
497965007750	Rrf2 family protein; Region: rrf2_super; TIGR00738
497965007751	Transcriptional regulator; Region: Rrf2; pfam02082
497965007752	Uncharacterized conserved protein [Function unknown]; Region: COG3791
497965007753	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
497965007754	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
497965007755	metal ion-dependent adhesion site (MIDAS); other site
497965007756	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08332
497965007757	magnesium chelatase subunit H; Provisional; Region: PRK12493
497965007758	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
497965007759	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
497965007760	FO synthase subunit 2; Reviewed; Region: PRK07360
497965007761	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965007762	FeS/SAM binding site; other site
497965007763	PRC-barrel domain; Region: PRC; pfam05239
497965007764	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
497965007765	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
497965007766	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
497965007767	homooctamer interface [polypeptide binding]; other site
497965007768	active site
497965007769	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965007770	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
497965007771	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965007772	ATP binding site [chemical binding]; other site
497965007773	putative Mg++ binding site [ion binding]; other site
497965007774	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965007775	nucleotide binding region [chemical binding]; other site
497965007776	ATP-binding site [chemical binding]; other site
497965007777	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
497965007778	HRDC domain; Region: HRDC; pfam00570
497965007779	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
497965007780	DNA binding residues [nucleotide binding]
497965007781	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
497965007782	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
497965007783	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
497965007784	RNA binding surface [nucleotide binding]; other site
497965007785	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
497965007786	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
497965007787	ligand binding site [chemical binding]; other site
497965007788	NAD binding site [chemical binding]; other site
497965007789	dimerization interface [polypeptide binding]; other site
497965007790	catalytic site [active]
497965007791	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
497965007792	putative L-serine binding site [chemical binding]; other site
497965007793	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
497965007794	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965007795	S-adenosylmethionine binding site [chemical binding]; other site
497965007796	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
497965007797	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
497965007798	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
497965007799	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
497965007800	active site
497965007801	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
497965007802	16S/18S rRNA binding site [nucleotide binding]; other site
497965007803	S13e-L30e interaction site [polypeptide binding]; other site
497965007804	25S rRNA binding site [nucleotide binding]; other site
497965007805	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
497965007806	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
497965007807	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
497965007808	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
497965007809	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
497965007810	active site
497965007811	nucleophile elbow; other site
497965007812	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965007813	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497965007814	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
497965007815	hypothetical protein; Validated; Region: PRK00029
497965007816	Uncharacterized conserved protein [Function unknown]; Region: COG0397
497965007817	GAF domain; Region: GAF_2; pfam13185
497965007818	GAF domain; Region: GAF; pfam01590
497965007819	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965007820	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965007821	metal binding site [ion binding]; metal-binding site
497965007822	active site
497965007823	I-site; other site
497965007824	Response regulator receiver domain; Region: Response_reg; pfam00072
497965007825	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965007826	active site
497965007827	phosphorylation site [posttranslational modification]
497965007828	intermolecular recognition site; other site
497965007829	dimerization interface [polypeptide binding]; other site
497965007830	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965007831	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965007832	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965007833	GAF domain; Region: GAF; pfam01590
497965007834	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965007835	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965007836	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965007837	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965007838	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965007839	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965007840	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965007841	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965007842	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965007843	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965007844	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965007845	PAS domain; Region: PAS; smart00091
497965007846	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965007847	dimer interface [polypeptide binding]; other site
497965007848	phosphorylation site [posttranslational modification]
497965007849	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965007850	ATP binding site [chemical binding]; other site
497965007851	Mg2+ binding site [ion binding]; other site
497965007852	G-X-G motif; other site
497965007853	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
497965007854	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
497965007855	active site
497965007856	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
497965007857	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
497965007858	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
497965007859	M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343
497965007860	glycogen branching enzyme; Provisional; Region: PRK05402
497965007861	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
497965007862	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
497965007863	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
497965007864	active site
497965007865	catalytic site [active]
497965007866	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
497965007867	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
497965007868	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
497965007869	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497965007870	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
497965007871	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497965007872	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
497965007873	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
497965007874	Hexamer interface [polypeptide binding]; other site
497965007875	Hexagonal pore residue; other site
497965007876	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
497965007877	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
497965007878	Hexamer interface [polypeptide binding]; other site
497965007879	Hexagonal pore residue; other site
497965007880	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
497965007881	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
497965007882	Hexamer interface [polypeptide binding]; other site
497965007883	Hexagonal pore residue; other site
497965007884	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
497965007885	Hexamer/Pentamer interface [polypeptide binding]; other site
497965007886	central pore; other site
497965007887	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
497965007888	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
497965007889	trimer interface [polypeptide binding]; other site
497965007890	active site
497965007891	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
497965007892	putative multimerization interface [polypeptide binding]; other site
497965007893	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
497965007894	putative multimerization interface [polypeptide binding]; other site
497965007895	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
497965007896	putative multimerization interface [polypeptide binding]; other site
497965007897	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
497965007898	putative multimerization interface [polypeptide binding]; other site
497965007899	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
497965007900	putative trimer interface [polypeptide binding]; other site
497965007901	putative CoA binding site [chemical binding]; other site
497965007902	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
497965007903	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
497965007904	homodimer interface [polypeptide binding]; other site
497965007905	active site
497965007906	heterodimer interface [polypeptide binding]; other site
497965007907	catalytic residue [active]
497965007908	metal binding site [ion binding]; metal-binding site
497965007909	RbcX protein; Region: RcbX; pfam02341
497965007910	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
497965007911	multimerization interface [polypeptide binding]; other site
497965007912	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965007913	putative active site [active]
497965007914	Uncharacterized conserved protein [Function unknown]; Region: COG2442
497965007915	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965007916	Protein of unknown function (DUF433); Region: DUF433; pfam04255
497965007917	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965007918	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965007919	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
497965007920	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965007921	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
497965007922	TAP-like protein; Region: Abhydrolase_4; pfam08386
497965007923	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
497965007924	MltA specific insert domain; Region: MltA; pfam03562
497965007925	3D domain; Region: 3D; pfam06725
497965007926	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
497965007927	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
497965007928	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
497965007929	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
497965007930	tRNA; other site
497965007931	putative tRNA binding site [nucleotide binding]; other site
497965007932	putative NADP binding site [chemical binding]; other site
497965007933	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
497965007934	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
497965007935	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
497965007936	putative active site [active]
497965007937	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
497965007938	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
497965007939	putative active site [active]
497965007940	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965007941	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965007942	dimer interface [polypeptide binding]; other site
497965007943	phosphorylation site [posttranslational modification]
497965007944	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965007945	ATP binding site [chemical binding]; other site
497965007946	Mg2+ binding site [ion binding]; other site
497965007947	G-X-G motif; other site
497965007948	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
497965007949	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
497965007950	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
497965007951	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
497965007952	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
497965007953	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
497965007954	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
497965007955	O-Antigen ligase; Region: Wzy_C; pfam04932
497965007956	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965007957	TPR motif; other site
497965007958	binding surface
497965007959	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
497965007960	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
497965007961	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
497965007962	putative substrate binding site [chemical binding]; other site
497965007963	putative ATP binding site [chemical binding]; other site
497965007964	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965007965	putative active site [active]
497965007966	ADP-glucose phosphorylase; Region: PLN02643
497965007967	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
497965007968	nucleotide binding site/active site [active]
497965007969	HIT family signature motif; other site
497965007970	catalytic residue [active]
497965007971	Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279
497965007972	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
497965007973	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965007974	Probable transposase; Region: OrfB_IS605; pfam01385
497965007975	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965007976	Transposase IS200 like; Region: Y1_Tnp; pfam01797
497965007977	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
497965007978	generic binding surface II; other site
497965007979	generic binding surface I; other site
497965007980	Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601
497965007981	Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722
497965007982	SnoaL-like domain; Region: SnoaL_2; pfam12680
497965007983	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965007984	S-adenosylmethionine binding site [chemical binding]; other site
497965007985	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
497965007986	putative active site [active]
497965007987	putative metal binding site [ion binding]; other site
497965007988	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
497965007989	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965007990	active site
497965007991	catalytic residues [active]
497965007992	DNA binding site [nucleotide binding]
497965007993	Int/Topo IB signature motif; other site
497965007994	Vta1 like; Region: DUF605; pfam04652
497965007995	Transposase; Region: DEDD_Tnp_IS110; pfam01548
497965007996	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
497965007997	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
497965007998	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
497965007999	protein I interface; other site
497965008000	D2 interface; other site
497965008001	protein T interface; other site
497965008002	chlorophyll binding site; other site
497965008003	beta carotene binding site; other site
497965008004	pheophytin binding site; other site
497965008005	manganese-stabilizing polypeptide interface; other site
497965008006	CP43 interface; other site
497965008007	protein L interface; other site
497965008008	oxygen evolving complex binding site; other site
497965008009	bromide binding site; other site
497965008010	quinone binding site; other site
497965008011	Fe binding site [ion binding]; other site
497965008012	core light harvesting interface; other site
497965008013	cytochrome b559 alpha subunit interface; other site
497965008014	cytochrome c-550 interface; other site
497965008015	protein J interface; other site
497965008016	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
497965008017	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
497965008018	Hemerythrin-like domain; Region: Hr-like; cd12108
497965008019	Fe binding site [ion binding]; other site
497965008020	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
497965008021	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
497965008022	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965008023	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
497965008024	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
497965008025	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
497965008026	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
497965008027	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
497965008028	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
497965008029	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
497965008030	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
497965008031	Active Sites [active]
497965008032	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
497965008033	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
497965008034	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
497965008035	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
497965008036	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497965008037	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497965008038	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965008039	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008040	active site
497965008041	phosphorylation site [posttranslational modification]
497965008042	intermolecular recognition site; other site
497965008043	dimerization interface [polypeptide binding]; other site
497965008044	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965008045	DNA binding site [nucleotide binding]
497965008046	Hpt domain; Region: Hpt; pfam01627
497965008047	putative binding surface; other site
497965008048	active site
497965008049	Response regulator receiver domain; Region: Response_reg; pfam00072
497965008050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008051	active site
497965008052	phosphorylation site [posttranslational modification]
497965008053	intermolecular recognition site; other site
497965008054	dimerization interface [polypeptide binding]; other site
497965008055	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965008056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008057	active site
497965008058	phosphorylation site [posttranslational modification]
497965008059	intermolecular recognition site; other site
497965008060	dimerization interface [polypeptide binding]; other site
497965008061	CHASE3 domain; Region: CHASE3; pfam05227
497965008062	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965008063	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965008064	putative active site [active]
497965008065	heme pocket [chemical binding]; other site
497965008066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965008067	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965008068	putative active site [active]
497965008069	heme pocket [chemical binding]; other site
497965008070	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965008071	putative active site [active]
497965008072	heme pocket [chemical binding]; other site
497965008073	PAS domain S-box; Region: sensory_box; TIGR00229
497965008074	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965008075	putative active site [active]
497965008076	heme pocket [chemical binding]; other site
497965008077	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965008078	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965008079	putative active site [active]
497965008080	heme pocket [chemical binding]; other site
497965008081	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965008082	dimer interface [polypeptide binding]; other site
497965008083	phosphorylation site [posttranslational modification]
497965008084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965008085	ATP binding site [chemical binding]; other site
497965008086	Mg2+ binding site [ion binding]; other site
497965008087	G-X-G motif; other site
497965008088	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965008089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008090	active site
497965008091	phosphorylation site [posttranslational modification]
497965008092	intermolecular recognition site; other site
497965008093	dimerization interface [polypeptide binding]; other site
497965008094	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
497965008095	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
497965008096	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
497965008097	PsaD; Region: PsaD; pfam02531
497965008098	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
497965008099	glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317
497965008100	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965008101	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965008102	putative active site [active]
497965008103	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
497965008104	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
497965008105	active site
497965008106	dimer interface [polypeptide binding]; other site
497965008107	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
497965008108	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
497965008109	active site
497965008110	FMN binding site [chemical binding]; other site
497965008111	substrate binding site [chemical binding]; other site
497965008112	3Fe-4S cluster binding site [ion binding]; other site
497965008113	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
497965008114	domain interface; other site
497965008115	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
497965008116	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965008117	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965008118	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
497965008119	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
497965008120	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
497965008121	homodimer interface [polypeptide binding]; other site
497965008122	metal binding site [ion binding]; metal-binding site
497965008123	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
497965008124	homodimer interface [polypeptide binding]; other site
497965008125	active site
497965008126	putative chemical substrate binding site [chemical binding]; other site
497965008127	metal binding site [ion binding]; metal-binding site
497965008128	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
497965008129	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
497965008130	Catalytic site [active]
497965008131	Uncharacterized conserved protein [Function unknown]; Region: COG0432
497965008132	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965008133	putative active site [active]
497965008134	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
497965008135	malate dehydrogenase; Reviewed; Region: PRK06223
497965008136	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
497965008137	NAD(P) binding site [chemical binding]; other site
497965008138	dimer interface [polypeptide binding]; other site
497965008139	tetramer (dimer of dimers) interface [polypeptide binding]; other site
497965008140	substrate binding site [chemical binding]; other site
497965008141	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
497965008142	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
497965008143	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
497965008144	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
497965008145	TM2 domain; Region: TM2; pfam05154
497965008146	Short C-terminal domain; Region: SHOCT; pfam09851
497965008147	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
497965008148	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
497965008149	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965008150	dimerization interface [polypeptide binding]; other site
497965008151	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965008152	dimerization interface [polypeptide binding]; other site
497965008153	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
497965008154	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965008155	dimerization interface [polypeptide binding]; other site
497965008156	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965008157	dimerization interface [polypeptide binding]; other site
497965008158	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
497965008159	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965008160	dimerization interface [polypeptide binding]; other site
497965008161	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965008162	dimerization interface [polypeptide binding]; other site
497965008163	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965008164	dimerization interface [polypeptide binding]; other site
497965008165	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965008166	dimerization interface [polypeptide binding]; other site
497965008167	GAF domain; Region: GAF_2; pfam13185
497965008168	GAF domain; Region: GAF; pfam01590
497965008169	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965008170	dimer interface [polypeptide binding]; other site
497965008171	phosphorylation site [posttranslational modification]
497965008172	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965008173	ATP binding site [chemical binding]; other site
497965008174	Mg2+ binding site [ion binding]; other site
497965008175	G-X-G motif; other site
497965008176	Response regulator receiver domain; Region: Response_reg; pfam00072
497965008177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008178	active site
497965008179	phosphorylation site [posttranslational modification]
497965008180	intermolecular recognition site; other site
497965008181	dimerization interface [polypeptide binding]; other site
497965008182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
497965008183	active site
497965008184	phosphorylation site [posttranslational modification]
497965008185	intermolecular recognition site; other site
497965008186	Response regulator receiver domain; Region: Response_reg; pfam00072
497965008187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008188	active site
497965008189	phosphorylation site [posttranslational modification]
497965008190	intermolecular recognition site; other site
497965008191	dimerization interface [polypeptide binding]; other site
497965008192	Response regulator receiver domain; Region: Response_reg; pfam00072
497965008193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008194	active site
497965008195	phosphorylation site [posttranslational modification]
497965008196	intermolecular recognition site; other site
497965008197	dimerization interface [polypeptide binding]; other site
497965008198	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965008199	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965008200	dimerization interface [polypeptide binding]; other site
497965008201	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965008202	dimer interface [polypeptide binding]; other site
497965008203	phosphorylation site [posttranslational modification]
497965008204	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965008205	ATP binding site [chemical binding]; other site
497965008206	Mg2+ binding site [ion binding]; other site
497965008207	G-X-G motif; other site
497965008208	Response regulator receiver domain; Region: Response_reg; pfam00072
497965008209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008210	active site
497965008211	phosphorylation site [posttranslational modification]
497965008212	intermolecular recognition site; other site
497965008213	dimerization interface [polypeptide binding]; other site
497965008214	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965008215	PAS fold; Region: PAS_3; pfam08447
497965008216	putative active site [active]
497965008217	heme pocket [chemical binding]; other site
497965008218	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
497965008219	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965008220	dimer interface [polypeptide binding]; other site
497965008221	phosphorylation site [posttranslational modification]
497965008222	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965008223	ATP binding site [chemical binding]; other site
497965008224	Mg2+ binding site [ion binding]; other site
497965008225	G-X-G motif; other site
497965008226	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965008227	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965008228	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
497965008229	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
497965008230	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
497965008231	glutathione synthetase; Provisional; Region: PRK05246
497965008232	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
497965008233	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
497965008234	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
497965008235	GSH binding site [chemical binding]; other site
497965008236	catalytic residues [active]
497965008237	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
497965008238	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965008239	TPR repeat; Region: TPR_11; pfam13414
497965008240	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965008241	binding surface
497965008242	TPR motif; other site
497965008243	TPR repeat; Region: TPR_11; pfam13414
497965008244	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965008245	binding surface
497965008246	TPR motif; other site
497965008247	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965008248	binding surface
497965008249	TPR repeat; Region: TPR_11; pfam13414
497965008250	TPR motif; other site
497965008251	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
497965008252	Tetratricopeptide repeat; Region: TPR_1; pfam00515
497965008253	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965008254	TPR motif; other site
497965008255	binding surface
497965008256	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
497965008257	binding surface
497965008258	TPR motif; other site
497965008259	Response regulator receiver domain; Region: Response_reg; pfam00072
497965008260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008261	active site
497965008262	phosphorylation site [posttranslational modification]
497965008263	intermolecular recognition site; other site
497965008264	dimerization interface [polypeptide binding]; other site
497965008265	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
497965008266	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
497965008267	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965008268	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
497965008269	non-specific DNA interactions [nucleotide binding]; other site
497965008270	DNA binding site [nucleotide binding]
497965008271	sequence specific DNA binding site [nucleotide binding]; other site
497965008272	putative cAMP binding site [chemical binding]; other site
497965008273	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
497965008274	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
497965008275	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
497965008276	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
497965008277	substrate binding site [chemical binding]; other site
497965008278	catalytic Zn binding site [ion binding]; other site
497965008279	NAD binding site [chemical binding]; other site
497965008280	structural Zn binding site [ion binding]; other site
497965008281	dimer interface [polypeptide binding]; other site
497965008282	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965008283	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
497965008284	Coenzyme A binding pocket [chemical binding]; other site
497965008285	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965008286	Putative addiction module component; Region: Unstab_antitox; pfam09720
497965008287	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
497965008288	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
497965008289	6-phosphofructokinase; Provisional; Region: PRK03202
497965008290	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
497965008291	active site
497965008292	ADP/pyrophosphate binding site [chemical binding]; other site
497965008293	dimerization interface [polypeptide binding]; other site
497965008294	allosteric effector site; other site
497965008295	fructose-1,6-bisphosphate binding site; other site
497965008296	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
497965008297	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
497965008298	putative active site [active]
497965008299	putative FMN binding site [chemical binding]; other site
497965008300	putative substrate binding site [chemical binding]; other site
497965008301	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
497965008302	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
497965008303	dimer interface [polypeptide binding]; other site
497965008304	PYR/PP interface [polypeptide binding]; other site
497965008305	TPP binding site [chemical binding]; other site
497965008306	substrate binding site [chemical binding]; other site
497965008307	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
497965008308	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
497965008309	Domain of unknown function; Region: EKR; pfam10371
497965008310	4Fe-4S binding domain; Region: Fer4_6; pfam12837
497965008311	4Fe-4S binding domain; Region: Fer4; pfam00037
497965008312	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
497965008313	TPP-binding site [chemical binding]; other site
497965008314	dimer interface [polypeptide binding]; other site
497965008315	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
497965008316	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
497965008317	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497965008318	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
497965008319	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965008320	motif II; other site
497965008321	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
497965008322	GUN4-like; Region: GUN4; pfam05419
497965008323	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965008324	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965008325	active site
497965008326	ATP binding site [chemical binding]; other site
497965008327	substrate binding site [chemical binding]; other site
497965008328	activation loop (A-loop); other site
497965008329	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965008330	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965008331	active site
497965008332	ATP binding site [chemical binding]; other site
497965008333	substrate binding site [chemical binding]; other site
497965008334	activation loop (A-loop); other site
497965008335	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
497965008336	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965008337	binding surface
497965008338	TPR motif; other site
497965008339	TPR repeat; Region: TPR_11; pfam13414
497965008340	TPR repeat; Region: TPR_11; pfam13414
497965008341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965008342	binding surface
497965008343	TPR motif; other site
497965008344	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
497965008345	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
497965008346	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
497965008347	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
497965008348	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
497965008349	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
497965008350	Probable Catalytic site; other site
497965008351	metal-binding site
497965008352	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
497965008353	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
497965008354	Probable Catalytic site; other site
497965008355	metal-binding site
497965008356	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965008357	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
497965008358	active site
497965008359	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965008360	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
497965008361	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
497965008362	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965008363	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
497965008364	putative ADP-binding pocket [chemical binding]; other site
497965008365	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965008366	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965008367	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965008368	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965008369	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965008370	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
497965008371	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
497965008372	Walker A/P-loop; other site
497965008373	ATP binding site [chemical binding]; other site
497965008374	Q-loop/lid; other site
497965008375	ABC transporter signature motif; other site
497965008376	Walker B; other site
497965008377	D-loop; other site
497965008378	H-loop/switch region; other site
497965008379	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
497965008380	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
497965008381	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
497965008382	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
497965008383	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
497965008384	P loop; other site
497965008385	Nucleotide binding site [chemical binding]; other site
497965008386	Switch I; other site
497965008387	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
497965008388	UbiA prenyltransferase family; Region: UbiA; pfam01040
497965008389	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
497965008390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
497965008391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
497965008392	FIST N domain; Region: FIST; pfam08495
497965008393	FIST C domain; Region: FIST_C; pfam10442
497965008394	CP12 domain; Region: CP12; pfam02672
497965008395	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
497965008396	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
497965008397	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
497965008398	active site
497965008399	substrate binding site [chemical binding]; other site
497965008400	metal binding site [ion binding]; metal-binding site
497965008401	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
497965008402	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965008403	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965008404	active site
497965008405	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965008406	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
497965008407	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965008408	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
497965008409	putative ADP-binding pocket [chemical binding]; other site
497965008410	FOG: CBS domain [General function prediction only]; Region: COG0517
497965008411	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
497965008412	FOG: CBS domain [General function prediction only]; Region: COG0517
497965008413	FOG: CBS domain [General function prediction only]; Region: COG0517
497965008414	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
497965008415	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965008416	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965008417	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965008418	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965008419	putative active site [active]
497965008420	heme pocket [chemical binding]; other site
497965008421	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965008422	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965008423	putative active site [active]
497965008424	heme pocket [chemical binding]; other site
497965008425	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965008426	putative active site [active]
497965008427	heme pocket [chemical binding]; other site
497965008428	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965008429	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965008430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965008431	dimer interface [polypeptide binding]; other site
497965008432	phosphorylation site [posttranslational modification]
497965008433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965008434	ATP binding site [chemical binding]; other site
497965008435	Mg2+ binding site [ion binding]; other site
497965008436	G-X-G motif; other site
497965008437	Response regulator receiver domain; Region: Response_reg; pfam00072
497965008438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008439	active site
497965008440	phosphorylation site [posttranslational modification]
497965008441	intermolecular recognition site; other site
497965008442	dimerization interface [polypeptide binding]; other site
497965008443	Response regulator receiver domain; Region: Response_reg; pfam00072
497965008444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008445	active site
497965008446	phosphorylation site [posttranslational modification]
497965008447	intermolecular recognition site; other site
497965008448	dimerization interface [polypeptide binding]; other site
497965008449	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965008450	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965008451	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965008452	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965008453	metal binding site [ion binding]; metal-binding site
497965008454	active site
497965008455	I-site; other site
497965008456	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965008457	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
497965008458	L-aspartate oxidase; Provisional; Region: PRK06175
497965008459	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
497965008460	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965008461	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
497965008462	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807
497965008463	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
497965008464	MASE1; Region: MASE1; pfam05231
497965008465	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965008466	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965008467	metal binding site [ion binding]; metal-binding site
497965008468	active site
497965008469	I-site; other site
497965008470	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
497965008471	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
497965008472	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965008473	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
497965008474	Immunoglobulin domain; Region: Ig; cl11960
497965008475	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
497965008476	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
497965008477	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
497965008478	Walker A/P-loop; other site
497965008479	ATP binding site [chemical binding]; other site
497965008480	Q-loop/lid; other site
497965008481	ABC transporter signature motif; other site
497965008482	Walker B; other site
497965008483	D-loop; other site
497965008484	H-loop/switch region; other site
497965008485	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
497965008486	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
497965008487	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
497965008488	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
497965008489	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
497965008490	Dimer interface [polypeptide binding]; other site
497965008491	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
497965008492	putative hydrophobic ligand binding site [chemical binding]; other site
497965008493	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
497965008494	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
497965008495	Short C-terminal domain; Region: SHOCT; pfam09851
497965008496	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
497965008497	Transglycosylase; Region: Transgly; pfam00912
497965008498	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
497965008499	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
497965008500	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
497965008501	Predicted membrane protein [Function unknown]; Region: COG2119
497965008502	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
497965008503	Predicted membrane protein [Function unknown]; Region: COG2119
497965008504	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
497965008505	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
497965008506	Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139
497965008507	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
497965008508	dimer interface [polypeptide binding]; other site
497965008509	[2Fe-2S] cluster binding site [ion binding]; other site
497965008510	response regulator FixJ; Provisional; Region: fixJ; PRK09390
497965008511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008512	active site
497965008513	phosphorylation site [posttranslational modification]
497965008514	intermolecular recognition site; other site
497965008515	dimerization interface [polypeptide binding]; other site
497965008516	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965008517	DNA binding residues [nucleotide binding]
497965008518	dimerization interface [polypeptide binding]; other site
497965008519	GMP synthase; Reviewed; Region: guaA; PRK00074
497965008520	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
497965008521	AMP/PPi binding site [chemical binding]; other site
497965008522	candidate oxyanion hole; other site
497965008523	catalytic triad [active]
497965008524	potential glutamine specificity residues [chemical binding]; other site
497965008525	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
497965008526	ATP Binding subdomain [chemical binding]; other site
497965008527	Ligand Binding sites [chemical binding]; other site
497965008528	Dimerization subdomain; other site
497965008529	DNA-sulfur modification-associated; Region: DndB; cl17621
497965008530	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
497965008531	active site
497965008532	GIY-YIG motif/motif A; other site
497965008533	catalytic site [active]
497965008534	metal binding site [ion binding]; metal-binding site
497965008535	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
497965008536	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
497965008537	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965008538	FeS/SAM binding site; other site
497965008539	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
497965008540	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497965008541	substrate binding pocket [chemical binding]; other site
497965008542	membrane-bound complex binding site; other site
497965008543	hinge residues; other site
497965008544	Transcriptional regulator [Transcription]; Region: LytR; COG1316
497965008545	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
497965008546	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
497965008547	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
497965008548	Ligand binding site; other site
497965008549	Putative Catalytic site; other site
497965008550	DXD motif; other site
497965008551	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
497965008552	DHH family; Region: DHH; pfam01368
497965008553	DHHA1 domain; Region: DHHA1; pfam02272
497965008554	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
497965008555	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
497965008556	nucleotide binding pocket [chemical binding]; other site
497965008557	K-X-D-G motif; other site
497965008558	catalytic site [active]
497965008559	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
497965008560	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
497965008561	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
497965008562	Dimer interface [polypeptide binding]; other site
497965008563	BRCT sequence motif; other site
497965008564	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965008565	putative active site [active]
497965008566	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
497965008567	nudix motif; other site
497965008568	argininosuccinate lyase; Provisional; Region: PRK00855
497965008569	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
497965008570	active sites [active]
497965008571	tetramer interface [polypeptide binding]; other site
497965008572	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965008573	GAF domain; Region: GAF_3; pfam13492
497965008574	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
497965008575	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
497965008576	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
497965008577	AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271
497965008578	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
497965008579	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965008580	active site
497965008581	legume lectins; Region: lectin_L-type; cd01951
497965008582	homotetramer interaction site [polypeptide binding]; other site
497965008583	carbohydrate binding site [chemical binding]; other site
497965008584	metal binding site [ion binding]; metal-binding site
497965008585	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
497965008586	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
497965008587	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965008588	binding surface
497965008589	TPR motif; other site
497965008590	Tetratricopeptide repeat; Region: TPR_9; pfam13371
497965008591	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
497965008592	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
497965008593	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
497965008594	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
497965008595	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965008596	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965008597	binding surface
497965008598	TPR motif; other site
497965008599	TPR repeat; Region: TPR_11; pfam13414
497965008600	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965008601	binding surface
497965008602	TPR motif; other site
497965008603	TPR repeat; Region: TPR_11; pfam13414
497965008604	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965008605	binding surface
497965008606	TPR motif; other site
497965008607	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
497965008608	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
497965008609	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
497965008610	active site
497965008611	dimer interface [polypeptide binding]; other site
497965008612	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
497965008613	PHP domain; Region: PHP; pfam02811
497965008614	active site
497965008615	Transglycosylase; Region: Transgly; pfam00912
497965008616	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
497965008617	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
497965008618	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
497965008619	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
497965008620	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
497965008621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
497965008622	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965008623	putative active site [active]
497965008624	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
497965008625	metal-binding site [ion binding]
497965008626	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
497965008627	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497965008628	putative DNA binding site [nucleotide binding]; other site
497965008629	putative Zn2+ binding site [ion binding]; other site
497965008630	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
497965008631	putative ABC transporter; Region: ycf24; CHL00085
497965008632	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
497965008633	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
497965008634	Walker A/P-loop; other site
497965008635	ATP binding site [chemical binding]; other site
497965008636	Q-loop/lid; other site
497965008637	ABC transporter signature motif; other site
497965008638	Walker B; other site
497965008639	D-loop; other site
497965008640	H-loop/switch region; other site
497965008641	FeS assembly protein SufD; Region: sufD; TIGR01981
497965008642	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
497965008643	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
497965008644	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
497965008645	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497965008646	catalytic residue [active]
497965008647	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
497965008648	Protein of unknown function (DUF433); Region: DUF433; cl01030
497965008649	Putative transposase; Region: Y2_Tnp; pfam04986
497965008650	EamA-like transporter family; Region: EamA; pfam00892
497965008651	EamA-like transporter family; Region: EamA; pfam00892
497965008652	Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320
497965008653	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
497965008654	UGMP family protein; Validated; Region: PRK09604
497965008655	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
497965008656	ribonuclease Z; Region: RNase_Z; TIGR02651
497965008657	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
497965008658	homotrimer interface [polypeptide binding]; other site
497965008659	Walker A motif; other site
497965008660	GTP binding site [chemical binding]; other site
497965008661	Walker B motif; other site
497965008662	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
497965008663	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
497965008664	putative metal binding site; other site
497965008665	putative acyl transferase; Provisional; Region: PRK10502
497965008666	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
497965008667	putative trimer interface [polypeptide binding]; other site
497965008668	putative active site [active]
497965008669	putative substrate binding site [chemical binding]; other site
497965008670	putative CoA binding site [chemical binding]; other site
497965008671	RNA methyltransferase, RsmE family; Region: TIGR00046
497965008672	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
497965008673	Radical SAM superfamily; Region: Radical_SAM; pfam04055
497965008674	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965008675	FeS/SAM binding site; other site
497965008676	Response regulator receiver domain; Region: Response_reg; pfam00072
497965008677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008678	active site
497965008679	phosphorylation site [posttranslational modification]
497965008680	intermolecular recognition site; other site
497965008681	dimerization interface [polypeptide binding]; other site
497965008682	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
497965008683	DHH family; Region: DHH; pfam01368
497965008684	DHHA1 domain; Region: DHHA1; pfam02272
497965008685	haemagglutination activity domain; Region: Haemagg_act; pfam05860
497965008686	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
497965008687	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
497965008688	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
497965008689	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965008690	dimerization interface [polypeptide binding]; other site
497965008691	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
497965008692	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965008693	putative active site [active]
497965008694	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
497965008695	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
497965008696	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
497965008697	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
497965008698	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
497965008699	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
497965008700	putative active site [active]
497965008701	putative NTP binding site [chemical binding]; other site
497965008702	putative nucleic acid binding site [nucleotide binding]; other site
497965008703	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
497965008704	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965008705	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965008706	active site
497965008707	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965008708	Probable transposase; Region: OrfB_IS605; pfam01385
497965008709	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965008710	Transposase IS200 like; Region: Y1_Tnp; pfam01797
497965008711	CpeS-like protein; Region: CpeS; pfam09367
497965008712	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
497965008713	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
497965008714	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
497965008715	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
497965008716	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
497965008717	ATP-grasp domain; Region: ATP-grasp_4; cl17255
497965008718	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
497965008719	IMP binding site; other site
497965008720	dimer interface [polypeptide binding]; other site
497965008721	interdomain contacts; other site
497965008722	partial ornithine binding site; other site
497965008723	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
497965008724	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
497965008725	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
497965008726	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
497965008727	D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173
497965008728	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905
497965008729	putative active site [active]
497965008730	Zn binding site [ion binding]; other site
497965008731	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
497965008732	excinuclease ABC subunit B; Provisional; Region: PRK05298
497965008733	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965008734	ATP binding site [chemical binding]; other site
497965008735	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965008736	nucleotide binding region [chemical binding]; other site
497965008737	ATP-binding site [chemical binding]; other site
497965008738	Ultra-violet resistance protein B; Region: UvrB; pfam12344
497965008739	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
497965008740	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
497965008741	NADP binding site [chemical binding]; other site
497965008742	substrate binding site [chemical binding]; other site
497965008743	active site
497965008744	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965008745	NACHT domain; Region: NACHT; pfam05729
497965008746	Walker A motif; other site
497965008747	ATP binding site [chemical binding]; other site
497965008748	Walker B motif; other site
497965008749	HEAT repeats; Region: HEAT_2; pfam13646
497965008750	HEAT repeats; Region: HEAT_2; pfam13646
497965008751	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
497965008752	protein binding surface [polypeptide binding]; other site
497965008753	HEAT repeats; Region: HEAT_2; pfam13646
497965008754	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
497965008755	protein binding surface [polypeptide binding]; other site
497965008756	HEAT repeats; Region: HEAT_2; pfam13646
497965008757	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
497965008758	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
497965008759	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
497965008760	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
497965008761	catalytic motif [active]
497965008762	Catalytic residue [active]
497965008763	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
497965008764	catalytic motif [active]
497965008765	Catalytic residue [active]
497965008766	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
497965008767	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
497965008768	putative active site [active]
497965008769	putative dimer interface [polypeptide binding]; other site
497965008770	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
497965008771	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
497965008772	active site
497965008773	polyphosphate kinase; Provisional; Region: PRK05443
497965008774	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
497965008775	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
497965008776	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
497965008777	putative domain interface [polypeptide binding]; other site
497965008778	putative active site [active]
497965008779	catalytic site [active]
497965008780	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
497965008781	putative domain interface [polypeptide binding]; other site
497965008782	putative active site [active]
497965008783	catalytic site [active]
497965008784	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
497965008785	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
497965008786	metal ion-dependent adhesion site (MIDAS); other site
497965008787	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
497965008788	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
497965008789	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
497965008790	Right handed beta helix region; Region: Beta_helix; pfam13229
497965008791	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965008792	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
497965008793	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965008794	TAP-like protein; Region: Abhydrolase_4; pfam08386
497965008795	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
497965008796	active site
497965008797	nucleophile elbow; other site
497965008798	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
497965008799	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
497965008800	Cl- selectivity filter; other site
497965008801	Cl- binding residues [ion binding]; other site
497965008802	pore gating glutamate residue; other site
497965008803	dimer interface [polypeptide binding]; other site
497965008804	H+/Cl- coupling transport residue; other site
497965008805	FOG: CBS domain [General function prediction only]; Region: COG0517
497965008806	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
497965008807	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
497965008808	Ligand Binding Site [chemical binding]; other site
497965008809	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497965008810	Ligand Binding Site [chemical binding]; other site
497965008811	Acyltransferase family; Region: Acyl_transf_3; pfam01757
497965008812	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965008813	putative active site [active]
497965008814	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965008815	putative active site [active]
497965008816	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
497965008817	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
497965008818	HIGH motif; other site
497965008819	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
497965008820	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
497965008821	active site
497965008822	KMSKS motif; other site
497965008823	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
497965008824	tRNA binding surface [nucleotide binding]; other site
497965008825	anticodon binding site; other site
497965008826	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
497965008827	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
497965008828	putative active site [active]
497965008829	homotetrameric interface [polypeptide binding]; other site
497965008830	metal binding site [ion binding]; metal-binding site
497965008831	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
497965008832	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
497965008833	catalytic triad [active]
497965008834	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
497965008835	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
497965008836	active site
497965008837	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
497965008838	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
497965008839	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
497965008840	FtsX-like permease family; Region: FtsX; pfam02687
497965008841	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
497965008842	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
497965008843	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
497965008844	Surface antigen; Region: Bac_surface_Ag; pfam01103
497965008845	uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792
497965008846	Double zinc ribbon; Region: DZR; pfam12773
497965008847	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
497965008848	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965008849	NAD(P) binding site [chemical binding]; other site
497965008850	active site
497965008851	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
497965008852	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
497965008853	NAD binding site [chemical binding]; other site
497965008854	homotetramer interface [polypeptide binding]; other site
497965008855	homodimer interface [polypeptide binding]; other site
497965008856	active site
497965008857	substrate binding site [chemical binding]; other site
497965008858	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
497965008859	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965008860	dimerization interface [polypeptide binding]; other site
497965008861	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965008862	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965008863	putative active site [active]
497965008864	heme pocket [chemical binding]; other site
497965008865	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965008866	dimer interface [polypeptide binding]; other site
497965008867	phosphorylation site [posttranslational modification]
497965008868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965008869	ATP binding site [chemical binding]; other site
497965008870	Mg2+ binding site [ion binding]; other site
497965008871	G-X-G motif; other site
497965008872	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
497965008873	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
497965008874	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
497965008875	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
497965008876	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965008877	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
497965008878	NAD(P) binding site [chemical binding]; other site
497965008879	active site
497965008880	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
497965008881	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
497965008882	GTP binding site; other site
497965008883	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
497965008884	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
497965008885	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
497965008886	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965008887	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965008888	phosphopeptide binding site; other site
497965008889	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
497965008890	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965008891	FeS/SAM binding site; other site
497965008892	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
497965008893	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965008894	putative active site [active]
497965008895	HAS barrel domain; Region: HAS-barrel; pfam09378
497965008896	HerA helicase [Replication, recombination, and repair]; Region: COG0433
497965008897	Domain of unknown function DUF87; Region: DUF87; pfam01935
497965008898	Transposase; Region: DDE_Tnp_ISL3; pfam01610
497965008899	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
497965008900	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
497965008901	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
497965008902	active site
497965008903	catalytic site [active]
497965008904	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
497965008905	tartrate dehydrogenase; Region: TTC; TIGR02089
497965008906	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
497965008907	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
497965008908	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
497965008909	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
497965008910	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
497965008911	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
497965008912	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
497965008913	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
497965008914	dimerization interface [polypeptide binding]; other site
497965008915	domain crossover interface; other site
497965008916	redox-dependent activation switch; other site
497965008917	sulfotransferase; Region: PLN02164
497965008918	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497965008919	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965008920	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965008921	active site
497965008922	catalytic residues [active]
497965008923	DNA binding site [nucleotide binding]
497965008924	Int/Topo IB signature motif; other site
497965008925	enoyl-CoA hydratase; Provisional; Region: PRK06072
497965008926	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965008927	non-specific DNA binding site [nucleotide binding]; other site
497965008928	salt bridge; other site
497965008929	sequence-specific DNA binding site [nucleotide binding]; other site
497965008930	Transposase; Region: DEDD_Tnp_IS110; pfam01548
497965008931	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
497965008932	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
497965008933	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
497965008934	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
497965008935	Repair protein; Region: Repair_PSII; pfam04536
497965008936	precorrin-8X methylmutase; Validated; Region: PRK05953
497965008937	Precorrin-8X methylmutase; Region: CbiC; pfam02570
497965008938	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
497965008939	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
497965008940	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
497965008941	Ligand Binding Site [chemical binding]; other site
497965008942	potassium-transporting ATPase subunit C; Provisional; Region: PRK14003
497965008943	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
497965008944	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497965008945	Soluble P-type ATPase [General function prediction only]; Region: COG4087
497965008946	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
497965008947	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965008948	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965008949	dimer interface [polypeptide binding]; other site
497965008950	phosphorylation site [posttranslational modification]
497965008951	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965008952	ATP binding site [chemical binding]; other site
497965008953	Mg2+ binding site [ion binding]; other site
497965008954	G-X-G motif; other site
497965008955	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965008956	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965008957	active site
497965008958	phosphorylation site [posttranslational modification]
497965008959	intermolecular recognition site; other site
497965008960	dimerization interface [polypeptide binding]; other site
497965008961	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965008962	DNA binding residues [nucleotide binding]
497965008963	dimerization interface [polypeptide binding]; other site
497965008964	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965008965	Coenzyme A binding pocket [chemical binding]; other site
497965008966	Uncharacterized conserved protein [Function unknown]; Region: COG5464
497965008967	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
497965008968	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
497965008969	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
497965008970	G1 box; other site
497965008971	GTP/Mg2+ binding site [chemical binding]; other site
497965008972	Switch I region; other site
497965008973	G2 box; other site
497965008974	G3 box; other site
497965008975	Switch II region; other site
497965008976	G4 box; other site
497965008977	G5 box; other site
497965008978	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
497965008979	Nucleoside recognition; Region: Gate; pfam07670
497965008980	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
497965008981	Nucleoside recognition; Region: Gate; pfam07670
497965008982	FeoA domain; Region: FeoA; pfam04023
497965008983	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
497965008984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965008985	putative substrate translocation pore; other site
497965008986	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
497965008987	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
497965008988	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
497965008989	homotetramer interface [polypeptide binding]; other site
497965008990	ligand binding site [chemical binding]; other site
497965008991	catalytic site [active]
497965008992	NAD binding site [chemical binding]; other site
497965008993	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
497965008994	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
497965008995	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
497965008996	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
497965008997	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965008998	non-specific DNA binding site [nucleotide binding]; other site
497965008999	salt bridge; other site
497965009000	sequence-specific DNA binding site [nucleotide binding]; other site
497965009001	PBP superfamily domain; Region: PBP_like; pfam12727
497965009002	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
497965009003	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965009004	putative active site [active]
497965009005	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
497965009006	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
497965009007	dimer interface [polypeptide binding]; other site
497965009008	putative anticodon binding site; other site
497965009009	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
497965009010	motif 1; other site
497965009011	active site
497965009012	motif 2; other site
497965009013	motif 3; other site
497965009014	KTSC domain; Region: KTSC; pfam13619
497965009015	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
497965009016	Cytochrome P450; Region: p450; pfam00067
497965009017	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
497965009018	DNA photolyase; Region: DNA_photolyase; pfam00875
497965009019	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
497965009020	metal binding site 2 [ion binding]; metal-binding site
497965009021	putative DNA binding helix; other site
497965009022	metal binding site 1 [ion binding]; metal-binding site
497965009023	dimer interface [polypeptide binding]; other site
497965009024	structural Zn2+ binding site [ion binding]; other site
497965009025	Response regulator receiver domain; Region: Response_reg; pfam00072
497965009026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009027	active site
497965009028	phosphorylation site [posttranslational modification]
497965009029	dimerization interface [polypeptide binding]; other site
497965009030	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
497965009031	FtsH Extracellular; Region: FtsH_ext; pfam06480
497965009032	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
497965009033	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965009034	Walker A motif; other site
497965009035	ATP binding site [chemical binding]; other site
497965009036	Walker B motif; other site
497965009037	arginine finger; other site
497965009038	Peptidase family M41; Region: Peptidase_M41; pfam01434
497965009039	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
497965009040	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
497965009041	Mg++ binding site [ion binding]; other site
497965009042	putative catalytic motif [active]
497965009043	putative substrate binding site [chemical binding]; other site
497965009044	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
497965009045	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
497965009046	putative active site [active]
497965009047	substrate binding site [chemical binding]; other site
497965009048	redox center [active]
497965009049	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
497965009050	Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434
497965009051	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
497965009052	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
497965009053	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965009054	FeS/SAM binding site; other site
497965009055	TRAM domain; Region: TRAM; cl01282
497965009056	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
497965009057	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
497965009058	ATP binding site [chemical binding]; other site
497965009059	Mg++ binding site [ion binding]; other site
497965009060	motif III; other site
497965009061	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965009062	nucleotide binding region [chemical binding]; other site
497965009063	ATP-binding site [chemical binding]; other site
497965009064	threonine synthase; Validated; Region: PRK06260
497965009065	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
497965009066	homodimer interface [polypeptide binding]; other site
497965009067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965009068	catalytic residue [active]
497965009069	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
497965009070	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965009071	AAA domain; Region: AAA_21; pfam13304
497965009072	Walker A/P-loop; other site
497965009073	ATP binding site [chemical binding]; other site
497965009074	AAA domain; Region: AAA_21; pfam13304
497965009075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
497965009076	Q-loop/lid; other site
497965009077	ABC transporter signature motif; other site
497965009078	Walker B; other site
497965009079	D-loop; other site
497965009080	H-loop/switch region; other site
497965009081	GTP-binding protein LepA; Provisional; Region: PRK05433
497965009082	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
497965009083	G1 box; other site
497965009084	putative GEF interaction site [polypeptide binding]; other site
497965009085	GTP/Mg2+ binding site [chemical binding]; other site
497965009086	Switch I region; other site
497965009087	G2 box; other site
497965009088	G3 box; other site
497965009089	Switch II region; other site
497965009090	G4 box; other site
497965009091	G5 box; other site
497965009092	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
497965009093	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
497965009094	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
497965009095	PAS domain S-box; Region: sensory_box; TIGR00229
497965009096	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965009097	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965009098	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965009099	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965009100	dimer interface [polypeptide binding]; other site
497965009101	phosphorylation site [posttranslational modification]
497965009102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965009103	ATP binding site [chemical binding]; other site
497965009104	Mg2+ binding site [ion binding]; other site
497965009105	G-X-G motif; other site
497965009106	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
497965009107	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
497965009108	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
497965009109	nucleoside/Zn binding site; other site
497965009110	dimer interface [polypeptide binding]; other site
497965009111	catalytic motif [active]
497965009112	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
497965009113	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965009114	putative substrate translocation pore; other site
497965009115	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965009116	mercuric reductase; Validated; Region: PRK06370
497965009117	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497965009118	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
497965009119	H+ Antiporter protein; Region: 2A0121; TIGR00900
497965009120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965009121	putative substrate translocation pore; other site
497965009122	multidrug resistance protein MdtN; Provisional; Region: PRK10476
497965009123	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497965009124	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965009125	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
497965009126	MarR family; Region: MarR; pfam01047
497965009127	NifU-like domain; Region: NifU; pfam01106
497965009128	Response regulator receiver domain; Region: Response_reg; pfam00072
497965009129	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009130	active site
497965009131	phosphorylation site [posttranslational modification]
497965009132	intermolecular recognition site; other site
497965009133	dimerization interface [polypeptide binding]; other site
497965009134	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965009135	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965009136	metal binding site [ion binding]; metal-binding site
497965009137	active site
497965009138	I-site; other site
497965009139	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965009140	PAS domain S-box; Region: sensory_box; TIGR00229
497965009141	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009142	putative active site [active]
497965009143	heme pocket [chemical binding]; other site
497965009144	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009145	PAS fold; Region: PAS_3; pfam08447
497965009146	putative active site [active]
497965009147	heme pocket [chemical binding]; other site
497965009148	PAS domain S-box; Region: sensory_box; TIGR00229
497965009149	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009150	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965009151	putative active site [active]
497965009152	heme pocket [chemical binding]; other site
497965009153	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009154	putative active site [active]
497965009155	heme pocket [chemical binding]; other site
497965009156	PAS domain S-box; Region: sensory_box; TIGR00229
497965009157	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009158	putative active site [active]
497965009159	heme pocket [chemical binding]; other site
497965009160	PAS domain S-box; Region: sensory_box; TIGR00229
497965009161	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009162	putative active site [active]
497965009163	heme pocket [chemical binding]; other site
497965009164	PAS fold; Region: PAS_4; pfam08448
497965009165	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009166	putative active site [active]
497965009167	heme pocket [chemical binding]; other site
497965009168	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965009169	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965009170	dimer interface [polypeptide binding]; other site
497965009171	phosphorylation site [posttranslational modification]
497965009172	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965009173	ATP binding site [chemical binding]; other site
497965009174	Mg2+ binding site [ion binding]; other site
497965009175	G-X-G motif; other site
497965009176	Response regulator receiver domain; Region: Response_reg; pfam00072
497965009177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009178	active site
497965009179	phosphorylation site [posttranslational modification]
497965009180	intermolecular recognition site; other site
497965009181	Ion transport protein; Region: Ion_trans; pfam00520
497965009182	Ion channel; Region: Ion_trans_2; pfam07885
497965009183	arogenate dehydrogenase; Reviewed; Region: PRK07417
497965009184	prephenate dehydrogenase; Validated; Region: PRK08507
497965009185	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497965009186	putative binding surface; other site
497965009187	active site
497965009188	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
497965009189	NmrA-like family; Region: NmrA; pfam05368
497965009190	NAD(P) binding site [chemical binding]; other site
497965009191	putative active site [active]
497965009192	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
497965009193	ATP-NAD kinase; Region: NAD_kinase; pfam01513
497965009194	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965009195	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
497965009196	Walker A/P-loop; other site
497965009197	ATP binding site [chemical binding]; other site
497965009198	Q-loop/lid; other site
497965009199	ABC transporter signature motif; other site
497965009200	Walker B; other site
497965009201	D-loop; other site
497965009202	H-loop/switch region; other site
497965009203	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
497965009204	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
497965009205	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
497965009206	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
497965009207	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
497965009208	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
497965009209	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
497965009210	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
497965009211	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
497965009212	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
497965009213	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
497965009214	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
497965009215	SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049
497965009216	reactive center loop; other site
497965009217	excinuclease ABC subunit A; Provisional; Region: PRK00635
497965009218	Inward rectifier potassium channel; Region: IRK; pfam01007
497965009219	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
497965009220	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
497965009221	Protein export membrane protein; Region: SecD_SecF; cl14618
497965009222	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
497965009223	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
497965009224	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
497965009225	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965009226	Predicted transcriptional regulators [Transcription]; Region: COG1695
497965009227	Transcriptional regulator PadR-like family; Region: PadR; cl17335
497965009228	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965009229	putative active site [active]
497965009230	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
497965009231	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
497965009232	active site residue [active]
497965009233	septum formation inhibitor; Provisional; Region: minC; PRK00030
497965009234	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
497965009235	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
497965009236	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
497965009237	active site
497965009238	Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425
497965009239	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
497965009240	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
497965009241	active site
497965009242	(T/H)XGH motif; other site
497965009243	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
497965009244	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
497965009245	putative substrate binding site [chemical binding]; other site
497965009246	nucleotide binding site [chemical binding]; other site
497965009247	nucleotide binding site [chemical binding]; other site
497965009248	homodimer interface [polypeptide binding]; other site
497965009249	Predicted GTPase [General function prediction only]; Region: COG2403
497965009250	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497965009251	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
497965009252	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
497965009253	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
497965009254	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
497965009255	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
497965009256	active site
497965009257	Preprotein translocase SecG subunit; Region: SecG; cl09123
497965009258	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
497965009259	phosphoglyceromutase; Provisional; Region: PRK05434
497965009260	Protein of unknown function (DUF433); Region: DUF433; cl01030
497965009261	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
497965009262	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497965009263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965009264	S-adenosylmethionine binding site [chemical binding]; other site
497965009265	glutamine synthetase, type I; Region: GlnA; TIGR00653
497965009266	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
497965009267	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
497965009268	allophycocyanin, beta subunit; Region: apcB; TIGR01337
497965009269	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
497965009270	pseudouridine synthase; Region: TIGR00093
497965009271	active site
497965009272	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965009273	Radical SAM superfamily; Region: Radical_SAM; pfam04055
497965009274	FeS/SAM binding site; other site
497965009275	Putative restriction endonuclease; Region: Uma2; pfam05685
497965009276	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965009277	putative active site [active]
497965009278	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
497965009279	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
497965009280	Pheophorbide a oxygenase; Region: PaO; pfam08417
497965009281	Response regulator receiver domain; Region: Response_reg; pfam00072
497965009282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009283	active site
497965009284	phosphorylation site [posttranslational modification]
497965009285	intermolecular recognition site; other site
497965009286	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965009287	dimerization interface [polypeptide binding]; other site
497965009288	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
497965009289	dimer interface [polypeptide binding]; other site
497965009290	phosphorylation site [posttranslational modification]
497965009291	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965009292	ATP binding site [chemical binding]; other site
497965009293	Mg2+ binding site [ion binding]; other site
497965009294	G-X-G motif; other site
497965009295	Predicted membrane protein [Function unknown]; Region: COG2119
497965009296	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
497965009297	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
497965009298	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
497965009299	PDGLE domain; Region: PDGLE; pfam13190
497965009300	cobalt transport protein CbiM; Validated; Region: PRK06265
497965009301	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
497965009302	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
497965009303	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
497965009304	Walker A/P-loop; other site
497965009305	ATP binding site [chemical binding]; other site
497965009306	Q-loop/lid; other site
497965009307	ABC transporter signature motif; other site
497965009308	Walker B; other site
497965009309	D-loop; other site
497965009310	H-loop/switch region; other site
497965009311	High-affinity nickel-transport protein; Region: NicO; cl00964
497965009312	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
497965009313	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
497965009314	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965009315	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
497965009316	active site
497965009317	ATP binding site [chemical binding]; other site
497965009318	substrate binding site [chemical binding]; other site
497965009319	activation loop (A-loop); other site
497965009320	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
497965009321	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
497965009322	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
497965009323	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965009324	circadian clock protein KaiC; Reviewed; Region: PRK09302
497965009325	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
497965009326	Walker A motif; other site
497965009327	Walker A motif; other site
497965009328	ATP binding site [chemical binding]; other site
497965009329	ATP binding site [chemical binding]; other site
497965009330	Walker B motif; other site
497965009331	recA bacterial DNA recombination protein; Region: RecA; cl17211
497965009332	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965009333	Walker A motif; other site
497965009334	ATP binding site [chemical binding]; other site
497965009335	Walker B motif; other site
497965009336	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
497965009337	tetramer interface [polypeptide binding]; other site
497965009338	dimer interface [polypeptide binding]; other site
497965009339	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965009340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009341	active site
497965009342	phosphorylation site [posttranslational modification]
497965009343	intermolecular recognition site; other site
497965009344	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
497965009345	Permease; Region: Permease; cl00510
497965009346	TPR repeat; Region: TPR_11; pfam13414
497965009347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009348	binding surface
497965009349	TPR motif; other site
497965009350	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
497965009351	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965009352	dimerization interface [polypeptide binding]; other site
497965009353	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
497965009354	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
497965009355	dimer interface [polypeptide binding]; other site
497965009356	putative CheW interface [polypeptide binding]; other site
497965009357	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
497965009358	Response regulator receiver domain; Region: Response_reg; pfam00072
497965009359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009360	active site
497965009361	phosphorylation site [posttranslational modification]
497965009362	intermolecular recognition site; other site
497965009363	dimerization interface [polypeptide binding]; other site
497965009364	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
497965009365	Response regulator receiver domain; Region: Response_reg; pfam00072
497965009366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009367	active site
497965009368	phosphorylation site [posttranslational modification]
497965009369	intermolecular recognition site; other site
497965009370	dimerization interface [polypeptide binding]; other site
497965009371	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
497965009372	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
497965009373	Ligand Binding Site [chemical binding]; other site
497965009374	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965009375	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965009376	Probable transposase; Region: OrfB_IS605; pfam01385
497965009377	cytochrome c biogenesis protein; Region: ccsA; CHL00045
497965009378	Family of unknown function (DUF490); Region: DUF490; pfam04357
497965009379	Uncharacterized conserved protein [Function unknown]; Region: COG3339
497965009380	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965009381	putative active site [active]
497965009382	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
497965009383	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
497965009384	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
497965009385	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497965009386	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965009387	CHAT domain; Region: CHAT; cl17868
497965009388	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965009389	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965009390	phosphopeptide binding site; other site
497965009391	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009392	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009393	binding surface
497965009394	TPR motif; other site
497965009395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009396	binding surface
497965009397	TPR motif; other site
497965009398	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009399	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009400	binding surface
497965009401	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009402	TPR motif; other site
497965009403	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009405	binding surface
497965009406	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009407	TPR motif; other site
497965009408	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009409	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009410	binding surface
497965009411	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009412	TPR motif; other site
497965009413	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009414	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009415	binding surface
497965009416	TPR motif; other site
497965009417	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009418	CHAT domain; Region: CHAT; pfam12770
497965009419	molecular chaperone DnaK; Provisional; Region: PRK13410
497965009420	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
497965009421	nucleotide binding site [chemical binding]; other site
497965009422	NEF interaction site [polypeptide binding]; other site
497965009423	SBD interface [polypeptide binding]; other site
497965009424	chaperone protein DnaJ; Provisional; Region: PRK14299
497965009425	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965009426	HSP70 interaction site [polypeptide binding]; other site
497965009427	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
497965009428	dimer interface [polypeptide binding]; other site
497965009429	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
497965009430	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
497965009431	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
497965009432	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965009433	FeS/SAM binding site; other site
497965009434	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497965009435	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
497965009436	substrate binding site [chemical binding]; other site
497965009437	oxyanion hole (OAH) forming residues; other site
497965009438	trimer interface [polypeptide binding]; other site
497965009439	Protein of unknown function (DUF721); Region: DUF721; cl02324
497965009440	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
497965009441	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
497965009442	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
497965009443	catalytic residues [active]
497965009444	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
497965009445	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497965009446	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965009447	homodimer interface [polypeptide binding]; other site
497965009448	catalytic residue [active]
497965009449	Rubrerythrin [Energy production and conversion]; Region: COG1592
497965009450	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
497965009451	binuclear metal center [ion binding]; other site
497965009452	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
497965009453	iron binding site [ion binding]; other site
497965009454	Uncharacterized conserved protein [Function unknown]; Region: COG2898
497965009455	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
497965009456	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
497965009457	Putative esterase; Region: Esterase; pfam00756
497965009458	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497965009459	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965009460	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
497965009461	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
497965009462	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
497965009463	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
497965009464	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
497965009465	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
497965009466	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497965009467	catalytic loop [active]
497965009468	iron binding site [ion binding]; other site
497965009469	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
497965009470	4Fe-4S binding domain; Region: Fer4; pfam00037
497965009471	hybrid cluster protein; Provisional; Region: PRK05290
497965009472	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
497965009473	ACS interaction site; other site
497965009474	CODH interaction site; other site
497965009475	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
497965009476	ACS interaction site; other site
497965009477	CODH interaction site; other site
497965009478	metal cluster binding site [ion binding]; other site
497965009479	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
497965009480	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
497965009481	NAD binding site [chemical binding]; other site
497965009482	substrate binding site [chemical binding]; other site
497965009483	catalytic Zn binding site [ion binding]; other site
497965009484	tetramer interface [polypeptide binding]; other site
497965009485	structural Zn binding site [ion binding]; other site
497965009486	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
497965009487	dimer interface [polypeptide binding]; other site
497965009488	[2Fe-2S] cluster binding site [ion binding]; other site
497965009489	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
497965009490	SLBB domain; Region: SLBB; pfam10531
497965009491	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
497965009492	bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571
497965009493	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
497965009494	putative dimer interface [polypeptide binding]; other site
497965009495	[2Fe-2S] cluster binding site [ion binding]; other site
497965009496	pantothenate kinase; Reviewed; Region: PRK13331
497965009497	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
497965009498	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965009499	motif II; other site
497965009500	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
497965009501	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
497965009502	putative NAD(P) binding site [chemical binding]; other site
497965009503	putative substrate binding site [chemical binding]; other site
497965009504	catalytic Zn binding site [ion binding]; other site
497965009505	structural Zn binding site [ion binding]; other site
497965009506	dimer interface [polypeptide binding]; other site
497965009507	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
497965009508	Protein of unknown function, DUF479; Region: DUF479; cl01203
497965009509	hydrolase, alpha/beta fold family protein; Region: PLN02824
497965009510	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
497965009511	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
497965009512	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
497965009513	Bacterial Ig-like domain; Region: Big_5; pfam13205
497965009514	Anti-sigma-K factor rskA; Region: RskA; pfam10099
497965009515	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965009516	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
497965009517	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
497965009518	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
497965009519	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
497965009520	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965009521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009522	active site
497965009523	phosphorylation site [posttranslational modification]
497965009524	intermolecular recognition site; other site
497965009525	dimerization interface [polypeptide binding]; other site
497965009526	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965009527	DNA binding site [nucleotide binding]
497965009528	Hpt domain; Region: Hpt; pfam01627
497965009529	putative binding surface; other site
497965009530	active site
497965009531	Response regulator receiver domain; Region: Response_reg; pfam00072
497965009532	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009533	active site
497965009534	phosphorylation site [posttranslational modification]
497965009535	intermolecular recognition site; other site
497965009536	dimerization interface [polypeptide binding]; other site
497965009537	Response regulator receiver domain; Region: Response_reg; pfam00072
497965009538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009539	active site
497965009540	phosphorylation site [posttranslational modification]
497965009541	intermolecular recognition site; other site
497965009542	dimerization interface [polypeptide binding]; other site
497965009543	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965009544	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965009545	metal binding site [ion binding]; metal-binding site
497965009546	active site
497965009547	I-site; other site
497965009548	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
497965009549	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
497965009550	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
497965009551	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
497965009552	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965009553	dimer interface [polypeptide binding]; other site
497965009554	conserved gate region; other site
497965009555	putative PBP binding loops; other site
497965009556	ABC-ATPase subunit interface; other site
497965009557	Inclusion body protein; Region: PixA; pfam12306
497965009558	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965009559	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
497965009560	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
497965009561	homotetramer interface [polypeptide binding]; other site
497965009562	FMN binding site [chemical binding]; other site
497965009563	homodimer contacts [polypeptide binding]; other site
497965009564	putative active site [active]
497965009565	putative substrate binding site [chemical binding]; other site
497965009566	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
497965009567	Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664
497965009568	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
497965009569	ATP-grasp domain; Region: ATP-grasp_4; cl17255
497965009570	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
497965009571	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
497965009572	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
497965009573	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
497965009574	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
497965009575	Predicted membrane protein [Function unknown]; Region: COG3431
497965009576	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
497965009577	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
497965009578	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
497965009579	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
497965009580	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
497965009581	active site
497965009582	substrate binding site [chemical binding]; other site
497965009583	cosubstrate binding site; other site
497965009584	catalytic site [active]
497965009585	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965009586	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
497965009587	CARDB; Region: CARDB; pfam07705
497965009588	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
497965009589	active site
497965009590	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
497965009591	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
497965009592	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
497965009593	active site
497965009594	Zn binding site [ion binding]; other site
497965009595	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965009596	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
497965009597	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009598	binding surface
497965009599	TPR motif; other site
497965009600	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009601	binding surface
497965009602	TPR motif; other site
497965009603	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009604	binding surface
497965009605	Tetratricopeptide repeat; Region: TPR_16; pfam13432
497965009606	TPR motif; other site
497965009607	TPR repeat; Region: TPR_11; pfam13414
497965009608	HEAT repeats; Region: HEAT_2; pfam13646
497965009609	RRXRR protein; Region: RRXRR; pfam14239
497965009610	FOG: CBS domain [General function prediction only]; Region: COG0517
497965009611	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
497965009612	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
497965009613	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965009614	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
497965009615	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965009616	DNA binding residues [nucleotide binding]
497965009617	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716
497965009618	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
497965009619	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
497965009620	active site
497965009621	substrate binding site [chemical binding]; other site
497965009622	metal binding site [ion binding]; metal-binding site
497965009623	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
497965009624	dimer interface [polypeptide binding]; other site
497965009625	[2Fe-2S] cluster binding site [ion binding]; other site
497965009626	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
497965009627	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
497965009628	dimerization interface [polypeptide binding]; other site
497965009629	DPS ferroxidase diiron center [ion binding]; other site
497965009630	ion pore; other site
497965009631	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
497965009632	PBP superfamily domain; Region: PBP_like_2; cl17296
497965009633	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
497965009634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965009635	dimer interface [polypeptide binding]; other site
497965009636	conserved gate region; other site
497965009637	putative PBP binding loops; other site
497965009638	ABC-ATPase subunit interface; other site
497965009639	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
497965009640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965009641	dimer interface [polypeptide binding]; other site
497965009642	conserved gate region; other site
497965009643	putative PBP binding loops; other site
497965009644	ABC-ATPase subunit interface; other site
497965009645	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
497965009646	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
497965009647	Walker A/P-loop; other site
497965009648	ATP binding site [chemical binding]; other site
497965009649	Q-loop/lid; other site
497965009650	ABC transporter signature motif; other site
497965009651	Walker B; other site
497965009652	D-loop; other site
497965009653	H-loop/switch region; other site
497965009654	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
497965009655	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
497965009656	Walker A/P-loop; other site
497965009657	ATP binding site [chemical binding]; other site
497965009658	Q-loop/lid; other site
497965009659	ABC transporter signature motif; other site
497965009660	Walker B; other site
497965009661	D-loop; other site
497965009662	H-loop/switch region; other site
497965009663	PBP superfamily domain; Region: PBP_like_2; cl17296
497965009664	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
497965009665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965009666	dimer interface [polypeptide binding]; other site
497965009667	conserved gate region; other site
497965009668	putative PBP binding loops; other site
497965009669	ABC-ATPase subunit interface; other site
497965009670	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
497965009671	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965009672	dimer interface [polypeptide binding]; other site
497965009673	conserved gate region; other site
497965009674	putative PBP binding loops; other site
497965009675	ABC-ATPase subunit interface; other site
497965009676	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
497965009677	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
497965009678	Walker A/P-loop; other site
497965009679	ATP binding site [chemical binding]; other site
497965009680	Q-loop/lid; other site
497965009681	ABC transporter signature motif; other site
497965009682	Walker B; other site
497965009683	D-loop; other site
497965009684	H-loop/switch region; other site
497965009685	Uncharacterized conserved protein [Function unknown]; Region: COG1432
497965009686	LabA_like proteins; Region: LabA; cd10911
497965009687	putative metal binding site [ion binding]; other site
497965009688	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
497965009689	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
497965009690	active site residue [active]
497965009691	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
497965009692	active site residue [active]
497965009693	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
497965009694	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965009695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009696	active site
497965009697	phosphorylation site [posttranslational modification]
497965009698	intermolecular recognition site; other site
497965009699	dimerization interface [polypeptide binding]; other site
497965009700	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
497965009701	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
497965009702	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
497965009703	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
497965009704	anti sigma factor interaction site; other site
497965009705	regulatory phosphorylation site [posttranslational modification]; other site
497965009706	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
497965009707	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965009708	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
497965009709	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965009710	NAD(P) binding site [chemical binding]; other site
497965009711	GUN4-like; Region: GUN4; pfam05419
497965009712	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965009713	putative active site [active]
497965009714	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
497965009715	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
497965009716	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
497965009717	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
497965009718	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
497965009719	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965009720	Coenzyme A binding pocket [chemical binding]; other site
497965009721	hypothetical protein; Provisional; Region: PRK11281
497965009722	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
497965009723	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965009724	Magnesium ion binding site [ion binding]; other site
497965009725	Predicted membrane protein [Function unknown]; Region: COG1950
497965009726	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
497965009727	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
497965009728	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
497965009729	Chromate transporter; Region: Chromate_transp; pfam02417
497965009730	Mg chelatase-related protein; Region: TIGR00368
497965009731	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
497965009732	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965009733	Walker A motif; other site
497965009734	ATP binding site [chemical binding]; other site
497965009735	Walker B motif; other site
497965009736	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
497965009737	Uncharacterized conserved protein [Function unknown]; Region: COG2433
497965009738	TPR repeat; Region: TPR_11; pfam13414
497965009739	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009740	binding surface
497965009741	TPR motif; other site
497965009742	TPR repeat; Region: TPR_11; pfam13414
497965009743	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009744	binding surface
497965009745	TPR motif; other site
497965009746	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
497965009747	binding surface
497965009748	TPR motif; other site
497965009749	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009750	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009751	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009752	binding surface
497965009753	TPR motif; other site
497965009754	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009755	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009756	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009757	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009758	binding surface
497965009759	TPR motif; other site
497965009760	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009761	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009762	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009763	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009764	binding surface
497965009765	TPR motif; other site
497965009766	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009767	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009768	CHAT domain; Region: CHAT; pfam12770
497965009769	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
497965009770	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
497965009771	active site
497965009772	catalytic site [active]
497965009773	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
497965009774	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
497965009775	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
497965009776	twin arginine translocase protein A; Provisional; Region: tatA; PRK14857
497965009777	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965009778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009779	active site
497965009780	phosphorylation site [posttranslational modification]
497965009781	intermolecular recognition site; other site
497965009782	dimerization interface [polypeptide binding]; other site
497965009783	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965009784	DNA binding site [nucleotide binding]
497965009785	hypothetical protein; Provisional; Region: PRK07394
497965009786	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
497965009787	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
497965009788	HEAT repeats; Region: HEAT_2; pfam13646
497965009789	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
497965009790	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
497965009791	active site
497965009792	SAM binding site [chemical binding]; other site
497965009793	homodimer interface [polypeptide binding]; other site
497965009794	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
497965009795	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
497965009796	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
497965009797	Response regulator receiver domain; Region: Response_reg; pfam00072
497965009798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965009799	active site
497965009800	phosphorylation site [posttranslational modification]
497965009801	intermolecular recognition site; other site
497965009802	dimerization interface [polypeptide binding]; other site
497965009803	PAS domain S-box; Region: sensory_box; TIGR00229
497965009804	PAS domain; Region: PAS; smart00091
497965009805	putative active site [active]
497965009806	heme pocket [chemical binding]; other site
497965009807	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965009808	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009809	putative active site [active]
497965009810	heme pocket [chemical binding]; other site
497965009811	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965009812	dimer interface [polypeptide binding]; other site
497965009813	phosphorylation site [posttranslational modification]
497965009814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965009815	ATP binding site [chemical binding]; other site
497965009816	Mg2+ binding site [ion binding]; other site
497965009817	G-X-G motif; other site
497965009818	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
497965009819	tetramer interface [polypeptide binding]; other site
497965009820	dimer interface [polypeptide binding]; other site
497965009821	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
497965009822	tetramer interface [polypeptide binding]; other site
497965009823	dimer interface [polypeptide binding]; other site
497965009824	circadian clock protein KaiC; Reviewed; Region: PRK09302
497965009825	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965009826	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965009827	Walker A motif; other site
497965009828	Walker A motif; other site
497965009829	ATP binding site [chemical binding]; other site
497965009830	Walker B motif; other site
497965009831	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965009832	Walker A motif; other site
497965009833	ATP binding site [chemical binding]; other site
497965009834	Walker B motif; other site
497965009835	GLTT repeat (6 copies); Region: GLTT; pfam01744
497965009836	GLTT repeat (6 copies); Region: GLTT; pfam01744
497965009837	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
497965009838	FAD binding site [chemical binding]; other site
497965009839	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
497965009840	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
497965009841	active site
497965009842	HIGH motif; other site
497965009843	dimer interface [polypeptide binding]; other site
497965009844	KMSKS motif; other site
497965009845	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
497965009846	oligomeric interface; other site
497965009847	putative active site [active]
497965009848	homodimer interface [polypeptide binding]; other site
497965009849	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
497965009850	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
497965009851	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
497965009852	Protein of unknown function (DUF565); Region: DUF565; pfam04483
497965009853	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
497965009854	PRC-barrel domain; Region: PRC; pfam05239
497965009855	PRC-barrel domain; Region: PRC; pfam05239
497965009856	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
497965009857	active site
497965009858	dimerization interface [polypeptide binding]; other site
497965009859	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
497965009860	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
497965009861	haemagglutination activity domain; Region: Haemagg_act; pfam05860
497965009862	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
497965009863	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
497965009864	CHASE2 domain; Region: CHASE2; pfam05226
497965009865	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965009866	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965009867	metal binding site [ion binding]; metal-binding site
497965009868	active site
497965009869	I-site; other site
497965009870	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
497965009871	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009872	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009873	binding surface
497965009874	TPR motif; other site
497965009875	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009876	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965009877	binding surface
497965009878	TPR motif; other site
497965009879	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009880	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965009881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
497965009882	haemagglutination activity domain; Region: Haemagg_act; pfam05860
497965009883	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
497965009884	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
497965009885	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
497965009886	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965009887	motif II; other site
497965009888	Putative phosphatase (DUF442); Region: DUF442; cl17385
497965009889	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965009890	Walker A motif; other site
497965009891	ATP binding site [chemical binding]; other site
497965009892	Walker B motif; other site
497965009893	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
497965009894	protein-splicing catalytic site; other site
497965009895	thioester formation/cholesterol transfer; other site
497965009896	Pretoxin HINT domain; Region: PT-HINT; pfam07591
497965009897	DNA polymerase III subunit delta'; Validated; Region: PRK08485
497965009898	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
497965009899	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
497965009900	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
497965009901	Walker A/P-loop; other site
497965009902	ATP binding site [chemical binding]; other site
497965009903	Q-loop/lid; other site
497965009904	ABC transporter signature motif; other site
497965009905	Walker B; other site
497965009906	D-loop; other site
497965009907	H-loop/switch region; other site
497965009908	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
497965009909	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
497965009910	Walker A/P-loop; other site
497965009911	ATP binding site [chemical binding]; other site
497965009912	Q-loop/lid; other site
497965009913	ABC transporter signature motif; other site
497965009914	Walker B; other site
497965009915	D-loop; other site
497965009916	H-loop/switch region; other site
497965009917	Class I aldolases; Region: Aldolase_Class_I; cl17187
497965009918	catalytic residue [active]
497965009919	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
497965009920	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
497965009921	Rubredoxin; Region: Rubredoxin; pfam00301
497965009922	iron binding site [ion binding]; other site
497965009923	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
497965009924	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
497965009925	putative NAD(P) binding site [chemical binding]; other site
497965009926	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
497965009927	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009928	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965009929	putative active site [active]
497965009930	heme pocket [chemical binding]; other site
497965009931	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009932	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965009933	putative active site [active]
497965009934	heme pocket [chemical binding]; other site
497965009935	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009936	putative active site [active]
497965009937	heme pocket [chemical binding]; other site
497965009938	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009939	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965009940	putative active site [active]
497965009941	heme pocket [chemical binding]; other site
497965009942	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009943	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965009944	putative active site [active]
497965009945	heme pocket [chemical binding]; other site
497965009946	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009947	putative active site [active]
497965009948	heme pocket [chemical binding]; other site
497965009949	PAS domain S-box; Region: sensory_box; TIGR00229
497965009950	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965009951	putative active site [active]
497965009952	heme pocket [chemical binding]; other site
497965009953	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965009954	dimer interface [polypeptide binding]; other site
497965009955	phosphorylation site [posttranslational modification]
497965009956	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965009957	ATP binding site [chemical binding]; other site
497965009958	Mg2+ binding site [ion binding]; other site
497965009959	G-X-G motif; other site
497965009960	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965009961	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
497965009962	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
497965009963	inhibitor binding site; inhibition site
497965009964	catalytic motif [active]
497965009965	Catalytic residue [active]
497965009966	Active site flap [active]
497965009967	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965009968	Walker A/P-loop; other site
497965009969	ATP binding site [chemical binding]; other site
497965009970	Protein of unknown function (DUF2691); Region: DUF2691; pfam10903
497965009971	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
497965009972	MarR family; Region: MarR; pfam01047
497965009973	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
497965009974	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
497965009975	E3 interaction surface; other site
497965009976	lipoyl attachment site [posttranslational modification]; other site
497965009977	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965009978	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
497965009979	Protein export membrane protein; Region: SecD_SecF; cl14618
497965009980	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
497965009981	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
497965009982	Ligand binding site; other site
497965009983	Putative Catalytic site; other site
497965009984	DXD motif; other site
497965009985	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
497965009986	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
497965009987	putative active site [active]
497965009988	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
497965009989	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
497965009990	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965009991	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
497965009992	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965009993	DNA binding residues [nucleotide binding]
497965009994	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
497965009995	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965009996	ATP binding site [chemical binding]; other site
497965009997	putative Mg++ binding site [ion binding]; other site
497965009998	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
497965009999	chaperone protein DnaJ; Provisional; Region: PRK14299
497965010000	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965010001	HSP70 interaction site [polypeptide binding]; other site
497965010002	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
497965010003	substrate binding site [polypeptide binding]; other site
497965010004	dimer interface [polypeptide binding]; other site
497965010005	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
497965010006	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
497965010007	Walker A/P-loop; other site
497965010008	ATP binding site [chemical binding]; other site
497965010009	Q-loop/lid; other site
497965010010	Plant protein of unknown function (DUF641); Region: DUF641; pfam04859
497965010011	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
497965010012	ABC transporter signature motif; other site
497965010013	Walker B; other site
497965010014	D-loop; other site
497965010015	H-loop/switch region; other site
497965010016	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
497965010017	Response regulator receiver domain; Region: Response_reg; pfam00072
497965010018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965010019	active site
497965010020	phosphorylation site [posttranslational modification]
497965010021	intermolecular recognition site; other site
497965010022	dimerization interface [polypeptide binding]; other site
497965010023	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
497965010024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965010025	putative active site [active]
497965010026	heme pocket [chemical binding]; other site
497965010027	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965010028	dimer interface [polypeptide binding]; other site
497965010029	phosphorylation site [posttranslational modification]
497965010030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965010031	ATP binding site [chemical binding]; other site
497965010032	Mg2+ binding site [ion binding]; other site
497965010033	G-X-G motif; other site
497965010034	Response regulator receiver domain; Region: Response_reg; pfam00072
497965010035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965010036	active site
497965010037	phosphorylation site [posttranslational modification]
497965010038	intermolecular recognition site; other site
497965010039	dimerization interface [polypeptide binding]; other site
497965010040	Protein kinase domain; Region: Pkinase; pfam00069
497965010041	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965010042	active site
497965010043	ATP binding site [chemical binding]; other site
497965010044	substrate binding site [chemical binding]; other site
497965010045	activation loop (A-loop); other site
497965010046	Predicted ATPase [General function prediction only]; Region: COG3899
497965010047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965010048	Walker A motif; other site
497965010049	ATP binding site [chemical binding]; other site
497965010050	Walker B motif; other site
497965010051	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965010052	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965010053	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965010054	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965010055	dimer interface [polypeptide binding]; other site
497965010056	phosphorylation site [posttranslational modification]
497965010057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965010058	ATP binding site [chemical binding]; other site
497965010059	Mg2+ binding site [ion binding]; other site
497965010060	G-X-G motif; other site
497965010061	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965010062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965010063	active site
497965010064	phosphorylation site [posttranslational modification]
497965010065	intermolecular recognition site; other site
497965010066	dimerization interface [polypeptide binding]; other site
497965010067	Phytochelatin synthase; Region: Phytochelatin; pfam05023
497965010068	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
497965010069	GTPase Era; Reviewed; Region: era; PRK00089
497965010070	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
497965010071	G1 box; other site
497965010072	GTP/Mg2+ binding site [chemical binding]; other site
497965010073	Switch I region; other site
497965010074	G2 box; other site
497965010075	Switch II region; other site
497965010076	G3 box; other site
497965010077	G4 box; other site
497965010078	G5 box; other site
497965010079	KH domain; Region: KH_2; pfam07650
497965010080	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
497965010081	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497965010082	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965010083	Walker A/P-loop; other site
497965010084	ATP binding site [chemical binding]; other site
497965010085	Q-loop/lid; other site
497965010086	ABC transporter signature motif; other site
497965010087	Walker B; other site
497965010088	D-loop; other site
497965010089	H-loop/switch region; other site
497965010090	photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877
497965010091	photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704
497965010092	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
497965010093	RuvA N terminal domain; Region: RuvA_N; pfam01330
497965010094	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
497965010095	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
497965010096	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497965010097	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
497965010098	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
497965010099	putative active site [active]
497965010100	putative dimer interface [polypeptide binding]; other site
497965010101	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
497965010102	Cytochrome P450; Region: p450; cl12078
497965010103	Domain of unknown function (DUF1817); Region: DUF1817; pfam08847
497965010104	gamma-glutamyl kinase; Provisional; Region: PRK05429
497965010105	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
497965010106	nucleotide binding site [chemical binding]; other site
497965010107	homotetrameric interface [polypeptide binding]; other site
497965010108	putative phosphate binding site [ion binding]; other site
497965010109	putative allosteric binding site; other site
497965010110	PUA domain; Region: PUA; pfam01472
497965010111	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
497965010112	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965010113	active site
497965010114	motif I; other site
497965010115	motif II; other site
497965010116	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965010117	Probable transposase; Region: OrfB_IS605; pfam01385
497965010118	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965010119	ferrochelatase; Reviewed; Region: hemH; PRK00035
497965010120	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
497965010121	active site
497965010122	C-terminal domain interface [polypeptide binding]; other site
497965010123	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
497965010124	active site
497965010125	N-terminal domain interface [polypeptide binding]; other site
497965010126	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504
497965010127	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
497965010128	active site pocket [active]
497965010129	putative dimer interface [polypeptide binding]; other site
497965010130	putative cataytic base [active]
497965010131	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
497965010132	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965010133	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965010134	ligand binding site [chemical binding]; other site
497965010135	flexible hinge region; other site
497965010136	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
497965010137	putative switch regulator; other site
497965010138	non-specific DNA interactions [nucleotide binding]; other site
497965010139	DNA binding site [nucleotide binding]
497965010140	sequence specific DNA binding site [nucleotide binding]; other site
497965010141	putative cAMP binding site [chemical binding]; other site
497965010142	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
497965010143	nucleotide binding site [chemical binding]; other site
497965010144	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
497965010145	Bacterial sugar transferase; Region: Bac_transf; pfam02397
497965010146	maltose O-acetyltransferase; Provisional; Region: PRK10092
497965010147	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
497965010148	active site
497965010149	substrate binding site [chemical binding]; other site
497965010150	trimer interface [polypeptide binding]; other site
497965010151	CoA binding site [chemical binding]; other site
497965010152	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
497965010153	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
497965010154	putative active site [active]
497965010155	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
497965010156	FOG: CBS domain [General function prediction only]; Region: COG0517
497965010157	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
497965010158	NifT/FixU protein; Region: NifT; pfam06988
497965010159	NifZ domain; Region: NifZ; pfam04319
497965010160	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
497965010161	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
497965010162	active site
497965010163	catalytic residues [active]
497965010164	metal binding site [ion binding]; metal-binding site
497965010165	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
497965010166	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
497965010167	serine O-acetyltransferase; Region: cysE; TIGR01172
497965010168	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
497965010169	trimer interface [polypeptide binding]; other site
497965010170	active site
497965010171	substrate binding site [chemical binding]; other site
497965010172	CoA binding site [chemical binding]; other site
497965010173	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
497965010174	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965010175	FeS/SAM binding site; other site
497965010176	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
497965010177	4Fe-4S binding domain; Region: Fer4; cl02805
497965010178	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
497965010179	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
497965010180	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
497965010181	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497965010182	catalytic residue [active]
497965010183	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
497965010184	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
497965010185	trimerization site [polypeptide binding]; other site
497965010186	active site
497965010187	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
497965010188	NifU-like domain; Region: NifU; pfam01106
497965010189	nitrogenase reductase; Reviewed; Region: PRK13236
497965010190	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
497965010191	Nucleotide-binding sites [chemical binding]; other site
497965010192	Walker A motif; other site
497965010193	Switch I region of nucleotide binding site; other site
497965010194	Fe4S4 binding sites [ion binding]; other site
497965010195	Switch II region of nucleotide binding site; other site
497965010196	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
497965010197	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
497965010198	MoFe protein alpha/beta subunit interactions; other site
497965010199	Alpha subunit P cluster binding residues; other site
497965010200	FeMoco binding residues [chemical binding]; other site
497965010201	MoFe protein alpha subunit/Fe protein contacts; other site
497965010202	MoFe protein dimer/ dimer interactions; other site
497965010203	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
497965010204	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
497965010205	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
497965010206	MoFe protein beta/alpha subunit interactions; other site
497965010207	Beta subunit P cluster binding residues; other site
497965010208	MoFe protein beta subunit/Fe protein contacts; other site
497965010209	MoFe protein dimer/ dimer interactions; other site
497965010210	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
497965010211	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
497965010212	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
497965010213	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
497965010214	Protein of unknown function, DUF269; Region: DUF269; cl03973
497965010215	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
497965010216	Protein of unknown function, DUF269; Region: DUF269; pfam03270
497965010217	Rop-like; Region: Rop-like; pfam05082
497965010218	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102
497965010219	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
497965010220	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
497965010221	ATP binding site [chemical binding]; other site
497965010222	substrate interface [chemical binding]; other site
497965010223	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
497965010224	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497965010225	catalytic loop [active]
497965010226	iron binding site [ion binding]; other site
497965010227	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
497965010228	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
497965010229	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
497965010230	4Fe-4S binding domain; Region: Fer4; pfam00037
497965010231	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
497965010232	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965010233	non-specific DNA binding site [nucleotide binding]; other site
497965010234	salt bridge; other site
497965010235	sequence-specific DNA binding site [nucleotide binding]; other site
497965010236	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
497965010237	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
497965010238	FAD binding domain; Region: FAD_binding_4; pfam01565
497965010239	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
497965010240	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497965010241	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965010242	DevC protein; Region: devC; TIGR01185
497965010243	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
497965010244	FtsX-like permease family; Region: FtsX; pfam02687
497965010245	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
497965010246	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
497965010247	Walker A/P-loop; other site
497965010248	ATP binding site [chemical binding]; other site
497965010249	Q-loop/lid; other site
497965010250	ABC transporter signature motif; other site
497965010251	Walker B; other site
497965010252	D-loop; other site
497965010253	H-loop/switch region; other site
497965010254	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497965010255	catalytic core [active]
497965010256	Peptidase family M48; Region: Peptidase_M48; pfam01435
497965010257	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
497965010258	conserved hypothetical protein; Region: TIGR03492
497965010259	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
497965010260	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
497965010261	Flavoprotein; Region: Flavoprotein; pfam02441
497965010262	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
497965010263	RRXRR protein; Region: RRXRR; pfam14239
497965010264	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965010265	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965010266	active site
497965010267	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
497965010268	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
497965010269	putative dimer interface [polypeptide binding]; other site
497965010270	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
497965010271	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965010272	catalytic site [active]
497965010273	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
497965010274	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
497965010275	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
497965010276	FtsH Extracellular; Region: FtsH_ext; pfam06480
497965010277	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
497965010278	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965010279	Walker A motif; other site
497965010280	ATP binding site [chemical binding]; other site
497965010281	Walker B motif; other site
497965010282	arginine finger; other site
497965010283	Peptidase family M41; Region: Peptidase_M41; pfam01434
497965010284	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
497965010285	putative rRNA binding site [nucleotide binding]; other site
497965010286	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965010287	putative active site [active]
497965010288	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
497965010289	hydrolase, alpha/beta fold family protein; Region: PLN02824
497965010290	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497965010291	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
497965010292	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965010293	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965010294	phosphopeptide binding site; other site
497965010295	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965010296	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965010297	metal binding site [ion binding]; metal-binding site
497965010298	active site
497965010299	I-site; other site
497965010300	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965010301	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
497965010302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965010303	Walker A/P-loop; other site
497965010304	ATP binding site [chemical binding]; other site
497965010305	Q-loop/lid; other site
497965010306	ABC transporter signature motif; other site
497965010307	Walker B; other site
497965010308	D-loop; other site
497965010309	H-loop/switch region; other site
497965010310	ABC-2 type transporter; Region: ABC2_membrane; cl17235
497965010311	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
497965010312	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965010313	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965010314	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
497965010315	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
497965010316	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
497965010317	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
497965010318	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
497965010319	TM-ABC transporter signature motif; other site
497965010320	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
497965010321	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
497965010322	Walker A/P-loop; other site
497965010323	ATP binding site [chemical binding]; other site
497965010324	Q-loop/lid; other site
497965010325	ABC transporter signature motif; other site
497965010326	Walker B; other site
497965010327	D-loop; other site
497965010328	H-loop/switch region; other site
497965010329	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
497965010330	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
497965010331	Ligand binding site; other site
497965010332	Putative Catalytic site; other site
497965010333	DXD motif; other site
497965010334	Predicted membrane protein [Function unknown]; Region: COG2246
497965010335	GtrA-like protein; Region: GtrA; pfam04138
497965010336	Uncharacterized conserved protein [Function unknown]; Region: COG1262
497965010337	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
497965010338	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
497965010339	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
497965010340	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
497965010341	Predicted membrane protein [Function unknown]; Region: COG3463
497965010342	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
497965010343	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
497965010344	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
497965010345	NurA domain; Region: NurA; pfam09376
497965010346	GTPase RsgA; Reviewed; Region: PRK12289
497965010347	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
497965010348	RNA binding site [nucleotide binding]; other site
497965010349	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
497965010350	GTPase/Zn-binding domain interface [polypeptide binding]; other site
497965010351	GTP/Mg2+ binding site [chemical binding]; other site
497965010352	G4 box; other site
497965010353	G5 box; other site
497965010354	G1 box; other site
497965010355	Switch I region; other site
497965010356	G2 box; other site
497965010357	G3 box; other site
497965010358	Switch II region; other site
497965010359	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
497965010360	CPxP  motif; other site
497965010361	chaperone protein DnaJ; Provisional; Region: PRK14293
497965010362	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965010363	HSP70 interaction site [polypeptide binding]; other site
497965010364	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
497965010365	substrate binding site [polypeptide binding]; other site
497965010366	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
497965010367	Zn binding sites [ion binding]; other site
497965010368	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
497965010369	dimer interface [polypeptide binding]; other site
497965010370	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
497965010371	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965010372	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
497965010373	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965010374	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
497965010375	protein binding site [polypeptide binding]; other site
497965010376	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
497965010377	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
497965010378	NADP binding site [chemical binding]; other site
497965010379	active site
497965010380	putative substrate binding site [chemical binding]; other site
497965010381	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
497965010382	pheophytin binding site; other site
497965010383	chlorophyll binding site; other site
497965010384	quinone binding site; other site
497965010385	Fe binding site [ion binding]; other site
497965010386	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
497965010387	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
497965010388	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
497965010389	CHASE2 domain; Region: CHASE2; pfam05226
497965010390	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
497965010391	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965010392	metal binding site [ion binding]; metal-binding site
497965010393	active site
497965010394	I-site; other site
497965010395	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965010396	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
497965010397	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
497965010398	metal binding site [ion binding]; metal-binding site
497965010399	dimer interface [polypeptide binding]; other site
497965010400	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497965010401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965010402	S-adenosylmethionine binding site [chemical binding]; other site
497965010403	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
497965010404	dihydrodipicolinate reductase; Provisional; Region: PRK00048
497965010405	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
497965010406	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
497965010407	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965010408	DNA binding site [nucleotide binding]
497965010409	Int/Topo IB signature motif; other site
497965010410	active site
497965010411	catalytic residues [active]
497965010412	Bifunctional nuclease; Region: DNase-RNase; pfam02577
497965010413	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
497965010414	intersubunit interface [polypeptide binding]; other site
497965010415	active site
497965010416	Zn2+ binding site [ion binding]; other site
497965010417	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
497965010418	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965010419	motif II; other site
497965010420	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
497965010421	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
497965010422	nucleotide binding site [chemical binding]; other site
497965010423	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
497965010424	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
497965010425	Uncharacterized conserved protein [Function unknown]; Region: COG5361
497965010426	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
497965010427	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
497965010428	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
497965010429	ALIX V-shaped domain binding to HIV; Region: ALIX_LYPXL_bnd; pfam13949
497965010430	linker region; other site
497965010431	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
497965010432	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
497965010433	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497965010434	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965010435	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
497965010436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965010437	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497965010438	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965010439	S-adenosylmethionine binding site [chemical binding]; other site
497965010440	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
497965010441	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
497965010442	Ligand binding site; other site
497965010443	Putative Catalytic site; other site
497965010444	DXD motif; other site
497965010445	short chain dehydrogenase; Validated; Region: PRK06182
497965010446	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
497965010447	NADP binding site [chemical binding]; other site
497965010448	active site
497965010449	steroid binding site; other site
497965010450	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
497965010451	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
497965010452	CoA binding domain; Region: CoA_binding; cl17356
497965010453	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
497965010454	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
497965010455	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
497965010456	active site
497965010457	catalytic tetrad [active]
497965010458	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
497965010459	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
497965010460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965010461	dimer interface [polypeptide binding]; other site
497965010462	ABC-ATPase subunit interface; other site
497965010463	putative PBP binding loops; other site
497965010464	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
497965010465	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
497965010466	inhibitor-cofactor binding pocket; inhibition site
497965010467	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965010468	catalytic residue [active]
497965010469	cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156
497965010470	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
497965010471	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
497965010472	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
497965010473	SLBB domain; Region: SLBB; pfam10531
497965010474	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
497965010475	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
497965010476	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
497965010477	Nucleotide binding site [chemical binding]; other site
497965010478	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
497965010479	cytochrome c-550; Provisional; Region: psbV; PRK13619
497965010480	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
497965010481	diphthine synthase; Region: dph5; TIGR00522
497965010482	active site
497965010483	SAM binding site [chemical binding]; other site
497965010484	homodimer interface [polypeptide binding]; other site
497965010485	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
497965010486	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
497965010487	putative active site [active]
497965010488	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
497965010489	putative active site [active]
497965010490	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
497965010491	CHASE2 domain; Region: CHASE2; pfam05226
497965010492	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
497965010493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965010494	dimer interface [polypeptide binding]; other site
497965010495	conserved gate region; other site
497965010496	putative PBP binding loops; other site
497965010497	ABC-ATPase subunit interface; other site
497965010498	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965010499	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965010500	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965010501	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965010502	phosphopeptide binding site; other site
497965010503	PAS domain S-box; Region: sensory_box; TIGR00229
497965010504	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965010505	putative active site [active]
497965010506	heme pocket [chemical binding]; other site
497965010507	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965010508	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965010509	metal binding site [ion binding]; metal-binding site
497965010510	active site
497965010511	I-site; other site
497965010512	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965010513	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965010514	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965010515	phosphopeptide binding site; other site
497965010516	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965010517	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965010518	metal binding site [ion binding]; metal-binding site
497965010519	active site
497965010520	I-site; other site
497965010521	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965010522	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965010523	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965010524	phosphopeptide binding site; other site
497965010525	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965010526	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965010527	metal binding site [ion binding]; metal-binding site
497965010528	active site
497965010529	I-site; other site
497965010530	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965010531	Predicted integral membrane protein [Function unknown]; Region: COG0392
497965010532	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
497965010533	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497965010534	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497965010535	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
497965010536	EamA-like transporter family; Region: EamA; cl17759
497965010537	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
497965010538	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
497965010539	active pocket/dimerization site; other site
497965010540	active site
497965010541	phosphorylation site [posttranslational modification]
497965010542	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
497965010543	dimerization domain swap beta strand [polypeptide binding]; other site
497965010544	regulatory protein interface [polypeptide binding]; other site
497965010545	active site
497965010546	regulatory phosphorylation site [posttranslational modification]; other site
497965010547	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
497965010548	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
497965010549	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
497965010550	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
497965010551	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
497965010552	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
497965010553	G1 box; other site
497965010554	GTP/Mg2+ binding site [chemical binding]; other site
497965010555	G2 box; other site
497965010556	Switch I region; other site
497965010557	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
497965010558	G3 box; other site
497965010559	Switch II region; other site
497965010560	GTP/Mg2+ binding site [chemical binding]; other site
497965010561	G4 box; other site
497965010562	G5 box; other site
497965010563	KGK domain; Region: KGK; pfam08872
497965010564	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965010565	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965010566	active site
497965010567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965010568	Walker A motif; other site
497965010569	ATP binding site [chemical binding]; other site
497965010570	Walker B motif; other site
497965010571	arginine finger; other site
497965010572	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965010573	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
497965010574	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
497965010575	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
497965010576	NAD binding site [chemical binding]; other site
497965010577	substrate binding site [chemical binding]; other site
497965010578	active site
497965010579	Protein of unknown function (DUF423); Region: DUF423; pfam04241
497965010580	Predicted ATPase [General function prediction only]; Region: COG4637
497965010581	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965010582	Walker A/P-loop; other site
497965010583	ATP binding site [chemical binding]; other site
497965010584	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965010585	Q-loop/lid; other site
497965010586	ABC transporter signature motif; other site
497965010587	Walker B; other site
497965010588	D-loop; other site
497965010589	H-loop/switch region; other site
497965010590	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
497965010591	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965010592	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
497965010593	Active_site [active]
497965010594	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
497965010595	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
497965010596	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
497965010597	Leucine rich repeat; Region: LRR_8; pfam13855
497965010598	Leucine-rich repeats; other site
497965010599	Substrate binding site [chemical binding]; other site
497965010600	Leucine rich repeat; Region: LRR_8; pfam13855
497965010601	Leucine rich repeat; Region: LRR_8; pfam13855
497965010602	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
497965010603	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
497965010604	G1 box; other site
497965010605	GTP/Mg2+ binding site [chemical binding]; other site
497965010606	G2 box; other site
497965010607	Switch I region; other site
497965010608	G3 box; other site
497965010609	Switch II region; other site
497965010610	G4 box; other site
497965010611	G5 box; other site
497965010612	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
497965010613	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
497965010614	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
497965010615	metal ion-dependent adhesion site (MIDAS); other site
497965010616	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
497965010617	metal ion-dependent adhesion site (MIDAS); other site
497965010618	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
497965010619	Family description; Region: UvrD_C_2; pfam13538
497965010620	Prophage antirepressor [Transcription]; Region: COG3617
497965010621	BRO family, N-terminal domain; Region: Bro-N; smart01040
497965010622	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
497965010623	Src Homology 3 domain superfamily; Region: SH3; cl17036
497965010624	peptide ligand binding site [polypeptide binding]; other site
497965010625	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
497965010626	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
497965010627	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
497965010628	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497965010629	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
497965010630	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965010631	active site
497965010632	catalytic residues [active]
497965010633	DNA binding site [nucleotide binding]
497965010634	Int/Topo IB signature motif; other site
497965010635	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
497965010636	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497965010637	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
497965010638	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
497965010639	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
497965010640	Bacterial sugar transferase; Region: Bac_transf; pfam02397
497965010641	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
497965010642	hydroxyglutarate oxidase; Provisional; Region: PRK11728
497965010643	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
497965010644	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
497965010645	Domain of unknown function (DUF305); Region: DUF305; pfam03713
497965010646	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965010647	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965010648	active site
497965010649	phosphorylation site [posttranslational modification]
497965010650	intermolecular recognition site; other site
497965010651	dimerization interface [polypeptide binding]; other site
497965010652	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965010653	DNA binding site [nucleotide binding]
497965010654	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965010655	dimer interface [polypeptide binding]; other site
497965010656	phosphorylation site [posttranslational modification]
497965010657	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965010658	ATP binding site [chemical binding]; other site
497965010659	Mg2+ binding site [ion binding]; other site
497965010660	G-X-G motif; other site
497965010661	Maf-like protein; Region: Maf; pfam02545
497965010662	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
497965010663	active site
497965010664	dimer interface [polypeptide binding]; other site
497965010665	PsbP; Region: PsbP; pfam01789
497965010666	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965010667	TPR repeat; Region: TPR_11; pfam13414
497965010668	binding surface
497965010669	TPR motif; other site
497965010670	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965010671	binding surface
497965010672	TPR motif; other site
497965010673	TPR repeat; Region: TPR_11; pfam13414
497965010674	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965010675	binding surface
497965010676	TPR motif; other site
497965010677	TPR repeat; Region: TPR_11; pfam13414
497965010678	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
497965010679	active site
497965010680	catalytic site [active]
497965010681	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
497965010682	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
497965010683	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
497965010684	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
497965010685	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
497965010686	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
497965010687	phage tail protein domain; Region: tail_TIGR02242
497965010688	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
497965010689	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
497965010690	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497965010691	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965010692	Magnesium ion binding site [ion binding]; other site
497965010693	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
497965010694	glutaminase A; Region: Gln_ase; TIGR03814
497965010695	PAS fold; Region: PAS_4; pfam08448
497965010696	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
497965010697	PAS domain S-box; Region: sensory_box; TIGR00229
497965010698	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965010699	putative active site [active]
497965010700	heme pocket [chemical binding]; other site
497965010701	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
497965010702	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
497965010703	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965010704	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965010705	ligand binding site [chemical binding]; other site
497965010706	flexible hinge region; other site
497965010707	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
497965010708	putative switch regulator; other site
497965010709	non-specific DNA interactions [nucleotide binding]; other site
497965010710	DNA binding site [nucleotide binding]
497965010711	sequence specific DNA binding site [nucleotide binding]; other site
497965010712	putative cAMP binding site [chemical binding]; other site
497965010713	hybrid cluster protein; Provisional; Region: PRK05290
497965010714	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
497965010715	ACS interaction site; other site
497965010716	CODH interaction site; other site
497965010717	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
497965010718	hybrid metal cluster; other site
497965010719	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
497965010720	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
497965010721	heme-binding site [chemical binding]; other site
497965010722	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
497965010723	active site
497965010724	catalytic residues [active]
497965010725	metal binding site [ion binding]; metal-binding site
497965010726	SOUL heme-binding protein; Region: SOUL; pfam04832
497965010727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
497965010728	Protein of unknown function, DUF482; Region: DUF482; pfam04339
497965010729	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
497965010730	RibD C-terminal domain; Region: RibD_C; cl17279
497965010731	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
497965010732	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
497965010733	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
497965010734	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
497965010735	active site
497965010736	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
497965010737	Nitrogen regulatory protein P-II; Region: P-II; smart00938
497965010738	Phycobilisome protein; Region: Phycobilisome; cl08227
497965010739	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
497965010740	multifunctional aminopeptidase A; Provisional; Region: PRK00913
497965010741	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
497965010742	interface (dimer of trimers) [polypeptide binding]; other site
497965010743	Substrate-binding/catalytic site; other site
497965010744	Zn-binding sites [ion binding]; other site
497965010745	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965010746	putative active site [active]
497965010747	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965010748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965010749	active site
497965010750	phosphorylation site [posttranslational modification]
497965010751	intermolecular recognition site; other site
497965010752	dimerization interface [polypeptide binding]; other site
497965010753	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965010754	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965010755	dimer interface [polypeptide binding]; other site
497965010756	phosphorylation site [posttranslational modification]
497965010757	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965010758	ATP binding site [chemical binding]; other site
497965010759	G-X-G motif; other site
497965010760	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
497965010761	FOG: CBS domain [General function prediction only]; Region: COG0517
497965010762	PAS domain S-box; Region: sensory_box; TIGR00229
497965010763	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965010764	putative active site [active]
497965010765	heme pocket [chemical binding]; other site
497965010766	PAS fold; Region: PAS_4; pfam08448
497965010767	PAS domain S-box; Region: sensory_box; TIGR00229
497965010768	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965010769	putative active site [active]
497965010770	heme pocket [chemical binding]; other site
497965010771	PAS domain S-box; Region: sensory_box; TIGR00229
497965010772	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965010773	putative active site [active]
497965010774	heme pocket [chemical binding]; other site
497965010775	PAS domain S-box; Region: sensory_box; TIGR00229
497965010776	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965010777	putative active site [active]
497965010778	heme pocket [chemical binding]; other site
497965010779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
497965010780	Histidine kinase; Region: HisKA_2; pfam07568
497965010781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965010782	ATP binding site [chemical binding]; other site
497965010783	Mg2+ binding site [ion binding]; other site
497965010784	G-X-G motif; other site
497965010785	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
497965010786	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
497965010787	active site
497965010788	metal binding site [ion binding]; metal-binding site
497965010789	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
497965010790	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
497965010791	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
497965010792	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
497965010793	active site
497965010794	catalytic triad [active]
497965010795	oxyanion hole [active]
497965010796	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497965010797	Ion channel; Region: Ion_trans_2; pfam07885
497965010798	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
497965010799	Eukaryotic homologues of bacterial periplasmic substrate binding proteins; Region: PBPe; smart00079
497965010800	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
497965010801	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
497965010802	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965010803	Coenzyme A binding pocket [chemical binding]; other site
497965010804	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
497965010805	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
497965010806	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965010807	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
497965010808	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965010809	Coenzyme A binding pocket [chemical binding]; other site
497965010810	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
497965010811	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
497965010812	active site
497965010813	Zn binding site [ion binding]; other site
497965010814	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
497965010815	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497965010816	putative di-iron ligands [ion binding]; other site
497965010817	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
497965010818	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
497965010819	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
497965010820	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965010821	S-adenosylmethionine binding site [chemical binding]; other site
497965010822	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497965010823	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
497965010824	C-terminal domain interface [polypeptide binding]; other site
497965010825	GSH binding site (G-site) [chemical binding]; other site
497965010826	dimer interface [polypeptide binding]; other site
497965010827	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
497965010828	N-terminal domain interface [polypeptide binding]; other site
497965010829	dimer interface [polypeptide binding]; other site
497965010830	substrate binding pocket (H-site) [chemical binding]; other site
497965010831	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965010832	Coenzyme A binding pocket [chemical binding]; other site
497965010833	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
497965010834	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
497965010835	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
497965010836	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
497965010837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965010838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965010839	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
497965010840	NMT1-like family; Region: NMT1_2; pfam13379
497965010841	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497965010842	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965010843	dimer interface [polypeptide binding]; other site
497965010844	conserved gate region; other site
497965010845	putative PBP binding loops; other site
497965010846	ABC-ATPase subunit interface; other site
497965010847	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497965010848	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
497965010849	Walker A/P-loop; other site
497965010850	ATP binding site [chemical binding]; other site
497965010851	Q-loop/lid; other site
497965010852	ABC transporter signature motif; other site
497965010853	Walker B; other site
497965010854	D-loop; other site
497965010855	H-loop/switch region; other site
497965010856	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
497965010857	NMT1-like family; Region: NMT1_2; pfam13379
497965010858	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497965010859	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
497965010860	Walker A/P-loop; other site
497965010861	ATP binding site [chemical binding]; other site
497965010862	Q-loop/lid; other site
497965010863	ABC transporter signature motif; other site
497965010864	Walker B; other site
497965010865	D-loop; other site
497965010866	H-loop/switch region; other site
497965010867	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965010868	putative active site [active]
497965010869	PAS fold; Region: PAS_4; pfam08448
497965010870	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965010871	putative active site [active]
497965010872	heme pocket [chemical binding]; other site
497965010873	PAS domain S-box; Region: sensory_box; TIGR00229
497965010874	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965010875	putative active site [active]
497965010876	heme pocket [chemical binding]; other site
497965010877	PAS domain S-box; Region: sensory_box; TIGR00229
497965010878	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965010879	putative active site [active]
497965010880	heme pocket [chemical binding]; other site
497965010881	PAS domain S-box; Region: sensory_box; TIGR00229
497965010882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965010883	putative active site [active]
497965010884	heme pocket [chemical binding]; other site
497965010885	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965010886	GAF domain; Region: GAF_3; pfam13492
497965010887	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965010888	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965010889	metal binding site [ion binding]; metal-binding site
497965010890	active site
497965010891	I-site; other site
497965010892	Rhomboid family; Region: Rhomboid; pfam01694
497965010893	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497965010894	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497965010895	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
497965010896	dimerization interface [polypeptide binding]; other site
497965010897	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
497965010898	hypothetical protein; Reviewed; Region: PRK09588
497965010899	GUN4-like; Region: GUN4; pfam05419
497965010900	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
497965010901	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
497965010902	dimer interface [polypeptide binding]; other site
497965010903	decamer (pentamer of dimers) interface [polypeptide binding]; other site
497965010904	catalytic triad [active]
497965010905	peroxidatic and resolving cysteines [active]
497965010906	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
497965010907	active site
497965010908	catalytic site [active]
497965010909	substrate binding site [chemical binding]; other site
497965010910	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
497965010911	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965010912	AAA domain; Region: AAA_22; pfam13401
497965010913	Walker A motif; other site
497965010914	ATP binding site [chemical binding]; other site
497965010915	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
497965010916	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
497965010917	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
497965010918	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
497965010919	catalytic motif [active]
497965010920	Zn binding site [ion binding]; other site
497965010921	RibD C-terminal domain; Region: RibD_C; cl17279
497965010922	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
497965010923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965010924	active site
497965010925	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965010926	phosphorylation site [posttranslational modification]
497965010927	intermolecular recognition site; other site
497965010928	dimerization interface [polypeptide binding]; other site
497965010929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965010930	ATP binding site [chemical binding]; other site
497965010931	Mg2+ binding site [ion binding]; other site
497965010932	G-X-G motif; other site
497965010933	Stage II sporulation protein; Region: SpoIID; pfam08486
497965010934	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965010935	Probable transposase; Region: OrfB_IS605; pfam01385
497965010936	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965010937	Ribbon-helix-helix domain; Region: RHH_4; cl01775
497965010938	Fic/DOC family; Region: Fic; cl00960
497965010939	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965010940	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965010941	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
497965010942	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
497965010943	nucleotide binding site [chemical binding]; other site
497965010944	NEF interaction site [polypeptide binding]; other site
497965010945	SBD interface [polypeptide binding]; other site
497965010946	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
497965010947	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
497965010948	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965010949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965010950	active site
497965010951	phosphorylation site [posttranslational modification]
497965010952	intermolecular recognition site; other site
497965010953	dimerization interface [polypeptide binding]; other site
497965010954	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965010955	DNA binding residues [nucleotide binding]
497965010956	dimerization interface [polypeptide binding]; other site
497965010957	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965010958	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965010959	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965010960	Transcriptional regulator [Transcription]; Region: LytR; COG1316
497965010961	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
497965010962	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
497965010963	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
497965010964	Substrate binding site; other site
497965010965	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
497965010966	ABC1 family; Region: ABC1; cl17513
497965010967	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
497965010968	putative active site [active]
497965010969	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
497965010970	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
497965010971	endonuclease III; Region: ENDO3c; smart00478
497965010972	minor groove reading motif; other site
497965010973	helix-hairpin-helix signature motif; other site
497965010974	substrate binding pocket [chemical binding]; other site
497965010975	active site
497965010976	putative molybdenum utilization protein ModD; Region: modD; TIGR01334
497965010977	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
497965010978	dimerization interface [polypeptide binding]; other site
497965010979	active site
497965010980	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
497965010981	putative catalytic site [active]
497965010982	putative phosphate binding site [ion binding]; other site
497965010983	active site
497965010984	metal binding site A [ion binding]; metal-binding site
497965010985	DNA binding site [nucleotide binding]
497965010986	putative AP binding site [nucleotide binding]; other site
497965010987	putative metal binding site B [ion binding]; other site
497965010988	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
497965010989	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
497965010990	cofactor binding site; other site
497965010991	DNA binding site [nucleotide binding]
497965010992	substrate interaction site [chemical binding]; other site
497965010993	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
497965010994	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
497965010995	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
497965010996	catalytic residues [active]
497965010997	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497965010998	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
497965010999	active site
497965011000	metal binding site [ion binding]; metal-binding site
497965011001	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
497965011002	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
497965011003	[2Fe-2S] cluster binding site [ion binding]; other site
497965011004	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
497965011005	PhoH-like protein; Region: PhoH; pfam02562
497965011006	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
497965011007	23S rRNA binding site [nucleotide binding]; other site
497965011008	L21 binding site [polypeptide binding]; other site
497965011009	L13 binding site [polypeptide binding]; other site
497965011010	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
497965011011	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
497965011012	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
497965011013	NAD binding site [chemical binding]; other site
497965011014	homodimer interface [polypeptide binding]; other site
497965011015	active site
497965011016	substrate binding site [chemical binding]; other site
497965011017	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
497965011018	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
497965011019	Substrate binding site; other site
497965011020	Mg++ binding site; other site
497965011021	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
497965011022	active site
497965011023	substrate binding site [chemical binding]; other site
497965011024	CoA binding site [chemical binding]; other site
497965011025	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
497965011026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965011027	active site
497965011028	phosphorylation site [posttranslational modification]
497965011029	intermolecular recognition site; other site
497965011030	dimerization interface [polypeptide binding]; other site
497965011031	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
497965011032	Zn2+ binding site [ion binding]; other site
497965011033	Mg2+ binding site [ion binding]; other site
497965011034	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; pfam05430
497965011035	cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153
497965011036	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
497965011037	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
497965011038	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
497965011039	putative ADP-binding pocket [chemical binding]; other site
497965011040	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965011041	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965011042	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
497965011043	DXD motif; other site
497965011044	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965011045	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
497965011046	active site
497965011047	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
497965011048	Bacterial sugar transferase; Region: Bac_transf; pfam02397
497965011049	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
497965011050	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
497965011051	Probable Catalytic site; other site
497965011052	metal-binding site
497965011053	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
497965011054	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
497965011055	trimer interface [polypeptide binding]; other site
497965011056	active site
497965011057	substrate binding site [chemical binding]; other site
497965011058	CoA binding site [chemical binding]; other site
497965011059	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
497965011060	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
497965011061	FAD binding domain; Region: FAD_binding_4; pfam01565
497965011062	Uncharacterized conserved protein [Function unknown]; Region: COG0398
497965011063	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
497965011064	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
497965011065	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
497965011066	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965011067	FeS/SAM binding site; other site
497965011068	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965011069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965011070	active site
497965011071	phosphorylation site [posttranslational modification]
497965011072	intermolecular recognition site; other site
497965011073	dimerization interface [polypeptide binding]; other site
497965011074	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965011075	DNA binding residues [nucleotide binding]
497965011076	dimerization interface [polypeptide binding]; other site
497965011077	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
497965011078	Src Homology 3 domain superfamily; Region: SH3; cl17036
497965011079	RES domain; Region: RES; pfam08808
497965011080	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
497965011081	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497965011082	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965011083	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
497965011084	Walker A/P-loop; other site
497965011085	ATP binding site [chemical binding]; other site
497965011086	Q-loop/lid; other site
497965011087	ABC transporter signature motif; other site
497965011088	Walker B; other site
497965011089	D-loop; other site
497965011090	H-loop/switch region; other site
497965011091	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965011092	putative substrate translocation pore; other site
497965011093	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497965011094	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965011095	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965011096	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965011097	ligand binding site [chemical binding]; other site
497965011098	flexible hinge region; other site
497965011099	DNA polymerase III subunit delta'; Validated; Region: PRK07399
497965011100	DNA polymerase III subunit delta'; Validated; Region: PRK08485
497965011101	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965011102	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965011103	phosphopeptide binding site; other site
497965011104	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
497965011105	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
497965011106	metal-binding site [ion binding]
497965011107	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497965011108	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965011109	motif II; other site
497965011110	B12 binding domain; Region: B12-binding; pfam02310
497965011111	B12 binding site [chemical binding]; other site
497965011112	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
497965011113	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965011114	FeS/SAM binding site; other site
497965011115	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
497965011116	Cupin domain; Region: Cupin_2; cl17218
497965011117	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
497965011118	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
497965011119	membrane protein; Provisional; Region: PRK14419
497965011120	acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531
497965011121	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
497965011122	carboxyltransferase (CT) interaction site; other site
497965011123	biotinylation site [posttranslational modification]; other site
497965011124	elongation factor P; Validated; Region: PRK00529
497965011125	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
497965011126	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
497965011127	RNA binding site [nucleotide binding]; other site
497965011128	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
497965011129	RNA binding site [nucleotide binding]; other site
497965011130	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
497965011131	active site
497965011132	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
497965011133	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
497965011134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965011135	active site
497965011136	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
497965011137	phosphorylation site [posttranslational modification]
497965011138	intermolecular recognition site; other site
497965011139	dimerization interface [polypeptide binding]; other site
497965011140	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965011141	metal binding site [ion binding]; metal-binding site
497965011142	active site
497965011143	I-site; other site
497965011144	Cache domain; Region: Cache_1; pfam02743
497965011145	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
497965011146	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965011147	dimerization interface [polypeptide binding]; other site
497965011148	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965011149	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965011150	putative active site [active]
497965011151	heme pocket [chemical binding]; other site
497965011152	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965011153	dimer interface [polypeptide binding]; other site
497965011154	phosphorylation site [posttranslational modification]
497965011155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965011156	ATP binding site [chemical binding]; other site
497965011157	Mg2+ binding site [ion binding]; other site
497965011158	G-X-G motif; other site
497965011159	Response regulator receiver domain; Region: Response_reg; pfam00072
497965011160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965011161	active site
497965011162	phosphorylation site [posttranslational modification]
497965011163	intermolecular recognition site; other site
497965011164	dimerization interface [polypeptide binding]; other site
497965011165	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
497965011166	hypothetical protein; Provisional; Region: PRK02724
497965011167	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
497965011168	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
497965011169	gamma subunit interface [polypeptide binding]; other site
497965011170	epsilon subunit interface [polypeptide binding]; other site
497965011171	LBP interface [polypeptide binding]; other site
497965011172	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
497965011173	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
497965011174	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
497965011175	alpha subunit interaction interface [polypeptide binding]; other site
497965011176	Walker A motif; other site
497965011177	ATP binding site [chemical binding]; other site
497965011178	Walker B motif; other site
497965011179	inhibitor binding site; inhibition site
497965011180	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
497965011181	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
497965011182	proposed catalytic triad [active]
497965011183	active site nucleophile [active]
497965011184	HEAT repeats; Region: HEAT_2; pfam13646
497965011185	HEAT repeats; Region: HEAT_2; pfam13646
497965011186	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
497965011187	protein binding surface [polypeptide binding]; other site
497965011188	HEAT repeats; Region: HEAT_2; pfam13646
497965011189	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
497965011190	CpeS-like protein; Region: CpeS; pfam09367
497965011191	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
497965011192	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
497965011193	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
497965011194	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
497965011195	Phycobilisome protein; Region: Phycobilisome; cl08227
497965011196	HEAT repeats; Region: HEAT_2; pfam13646
497965011197	HEAT repeats; Region: HEAT_2; pfam13646
497965011198	HEAT repeats; Region: HEAT_2; pfam13646
497965011199	dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247
497965011200	phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13250
497965011201	CpeS-like protein; Region: CpeS; pfam09367
497965011202	HicB family; Region: HicB; pfam05534
497965011203	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965011204	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011205	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011206	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011207	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011208	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965011209	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011210	Phycobilisome protein; Region: Phycobilisome; cl08227
497965011211	Phycobilisome protein; Region: Phycobilisome; cl08227
497965011212	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
497965011213	HEAT repeats; Region: HEAT_2; pfam13646
497965011214	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
497965011215	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
497965011216	HEAT repeats; Region: HEAT_2; pfam13646
497965011217	protein binding surface [polypeptide binding]; other site
497965011218	HEAT repeats; Region: HEAT_2; pfam13646
497965011219	lipoyl synthase; Provisional; Region: PRK05481
497965011220	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
497965011221	FeS/SAM binding site; other site
497965011222	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
497965011223	Response regulator receiver domain; Region: Response_reg; pfam00072
497965011224	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965011225	active site
497965011226	phosphorylation site [posttranslational modification]
497965011227	intermolecular recognition site; other site
497965011228	dimerization interface [polypeptide binding]; other site
497965011229	PAS domain S-box; Region: sensory_box; TIGR00229
497965011230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965011231	putative active site [active]
497965011232	heme pocket [chemical binding]; other site
497965011233	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965011234	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965011235	putative active site [active]
497965011236	heme pocket [chemical binding]; other site
497965011237	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965011238	putative active site [active]
497965011239	heme pocket [chemical binding]; other site
497965011240	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965011241	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965011242	putative active site [active]
497965011243	heme pocket [chemical binding]; other site
497965011244	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965011245	dimer interface [polypeptide binding]; other site
497965011246	phosphorylation site [posttranslational modification]
497965011247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965011248	ATP binding site [chemical binding]; other site
497965011249	Mg2+ binding site [ion binding]; other site
497965011250	G-X-G motif; other site
497965011251	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965011252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965011253	active site
497965011254	phosphorylation site [posttranslational modification]
497965011255	intermolecular recognition site; other site
497965011256	dimerization interface [polypeptide binding]; other site
497965011257	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965011258	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965011259	metal binding site [ion binding]; metal-binding site
497965011260	active site
497965011261	I-site; other site
497965011262	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965011263	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
497965011264	FOG: CBS domain [General function prediction only]; Region: COG0517
497965011265	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
497965011266	PAS domain S-box; Region: sensory_box; TIGR00229
497965011267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965011268	putative active site [active]
497965011269	heme pocket [chemical binding]; other site
497965011270	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965011271	PAS fold; Region: PAS_3; pfam08447
497965011272	putative active site [active]
497965011273	heme pocket [chemical binding]; other site
497965011274	GAF domain; Region: GAF_3; pfam13492
497965011275	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965011276	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965011277	PAS fold; Region: PAS_3; pfam08447
497965011278	putative active site [active]
497965011279	heme pocket [chemical binding]; other site
497965011280	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965011281	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965011282	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965011283	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965011284	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965011285	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965011286	dimer interface [polypeptide binding]; other site
497965011287	phosphorylation site [posttranslational modification]
497965011288	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965011289	ATP binding site [chemical binding]; other site
497965011290	Mg2+ binding site [ion binding]; other site
497965011291	G-X-G motif; other site
497965011292	Response regulator receiver domain; Region: Response_reg; pfam00072
497965011293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965011294	active site
497965011295	phosphorylation site [posttranslational modification]
497965011296	intermolecular recognition site; other site
497965011297	dimerization interface [polypeptide binding]; other site
497965011298	Response regulator receiver domain; Region: Response_reg; pfam00072
497965011299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965011300	active site
497965011301	phosphorylation site [posttranslational modification]
497965011302	intermolecular recognition site; other site
497965011303	dimerization interface [polypeptide binding]; other site
497965011304	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
497965011305	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
497965011306	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965011307	TPR repeat; Region: TPR_11; pfam13414
497965011308	binding surface
497965011309	TPR motif; other site
497965011310	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965011311	binding surface
497965011312	TPR motif; other site
497965011313	TPR repeat; Region: TPR_11; pfam13414
497965011314	TPR repeat; Region: TPR_11; pfam13414
497965011315	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965011316	binding surface
497965011317	TPR motif; other site
497965011318	TPR repeat; Region: TPR_11; pfam13414
497965011319	GUN4-like; Region: GUN4; pfam05419
497965011320	PAS domain S-box; Region: sensory_box; TIGR00229
497965011321	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965011322	putative active site [active]
497965011323	heme pocket [chemical binding]; other site
497965011324	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
497965011325	aromatic arch; other site
497965011326	DCoH dimer interaction site [polypeptide binding]; other site
497965011327	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
497965011328	DCoH tetramer interaction site [polypeptide binding]; other site
497965011329	substrate binding site [chemical binding]; other site
497965011330	Repair protein; Region: Repair_PSII; pfam04536
497965011331	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
497965011332	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
497965011333	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
497965011334	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
497965011335	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965011336	Probable transposase; Region: OrfB_IS605; pfam01385
497965011337	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965011338	Transposase IS200 like; Region: Y1_Tnp; pfam01797
497965011339	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
497965011340	DoxX; Region: DoxX; pfam07681
497965011341	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
497965011342	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
497965011343	DHH family; Region: DHH; pfam01368
497965011344	FOG: CBS domain [General function prediction only]; Region: COG0517
497965011345	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
497965011346	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
497965011347	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
497965011348	active site
497965011349	NTP binding site [chemical binding]; other site
497965011350	metal binding triad [ion binding]; metal-binding site
497965011351	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
497965011352	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
497965011353	phosphoribulokinase; Provisional; Region: PRK07429
497965011354	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
497965011355	active site
497965011356	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
497965011357	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
497965011358	Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304
497965011359	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965011360	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965011361	active site
497965011362	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
497965011363	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
497965011364	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
497965011365	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
497965011366	N-acetyl-D-glucosamine binding site [chemical binding]; other site
497965011367	catalytic residue [active]
497965011368	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
497965011369	active site
497965011370	metal binding site [ion binding]; metal-binding site
497965011371	interdomain interaction site; other site
497965011372	Virulence-associated protein E; Region: VirE; pfam05272
497965011373	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497965011374	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497965011375	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
497965011376	non-specific DNA binding site [nucleotide binding]; other site
497965011377	salt bridge; other site
497965011378	sequence-specific DNA binding site [nucleotide binding]; other site
497965011379	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497965011380	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965011381	active site
497965011382	catalytic residues [active]
497965011383	DNA binding site [nucleotide binding]
497965011384	Int/Topo IB signature motif; other site
497965011385	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965011386	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
497965011387	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
497965011388	dimer interface [polypeptide binding]; other site
497965011389	putative functional site; other site
497965011390	putative MPT binding site; other site
497965011391	Cytochrome c; Region: Cytochrom_C; cl11414
497965011392	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
497965011393	TPR repeat; Region: TPR_11; pfam13414
497965011394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965011395	binding surface
497965011396	TPR motif; other site
497965011397	TPR repeat; Region: TPR_11; pfam13414
497965011398	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965011399	binding surface
497965011400	TPR motif; other site
497965011401	TPR repeat; Region: TPR_11; pfam13414
497965011402	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
497965011403	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965011404	WD40 repeats; Region: WD40; smart00320
497965011405	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965011406	structural tetrad; other site
497965011407	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965011408	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965011409	structural tetrad; other site
497965011410	WD domain, G-beta repeat; Region: WD40; pfam00400
497965011411	dihydroorotase; Provisional; Region: PRK07575
497965011412	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
497965011413	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
497965011414	active site
497965011415	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
497965011416	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
497965011417	Catalytic site [active]
497965011418	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
497965011419	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
497965011420	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497965011421	active site
497965011422	AAA domain; Region: AAA_26; pfam13500
497965011423	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
497965011424	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
497965011425	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965011426	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
497965011427	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
497965011428	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965011429	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965011430	active site
497965011431	ATP binding site [chemical binding]; other site
497965011432	substrate binding site [chemical binding]; other site
497965011433	activation loop (A-loop); other site
497965011434	TPR repeat; Region: TPR_11; pfam13414
497965011435	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
497965011436	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
497965011437	putative ligand binding site [chemical binding]; other site
497965011438	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
497965011439	active site
497965011440	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011441	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965011442	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011443	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011444	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
497965011445	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
497965011446	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
497965011447	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
497965011448	active site
497965011449	dimer interface [polypeptide binding]; other site
497965011450	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
497965011451	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
497965011452	active site
497965011453	FMN binding site [chemical binding]; other site
497965011454	substrate binding site [chemical binding]; other site
497965011455	3Fe-4S cluster binding site [ion binding]; other site
497965011456	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
497965011457	domain interface; other site
497965011458	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
497965011459	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
497965011460	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
497965011461	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
497965011462	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
497965011463	hypothetical protein; Provisional; Region: PRK04194
497965011464	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
497965011465	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965011466	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011467	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965011468	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497965011469	LysR family transcriptional regulator; Provisional; Region: PRK14997
497965011470	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
497965011471	putative effector binding pocket; other site
497965011472	dimerization interface [polypeptide binding]; other site
497965011473	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
497965011474	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
497965011475	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
497965011476	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
497965011477	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
497965011478	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
497965011479	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
497965011480	NADP binding site [chemical binding]; other site
497965011481	active site
497965011482	putative substrate binding site [chemical binding]; other site
497965011483	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
497965011484	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
497965011485	substrate binding site; other site
497965011486	metal-binding site
497965011487	Oligomer interface; other site
497965011488	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
497965011489	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
497965011490	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
497965011491	NAD binding site [chemical binding]; other site
497965011492	substrate binding site [chemical binding]; other site
497965011493	homodimer interface [polypeptide binding]; other site
497965011494	active site
497965011495	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
497965011496	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
497965011497	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
497965011498	AMP binding site [chemical binding]; other site
497965011499	metal binding site [ion binding]; metal-binding site
497965011500	active site
497965011501	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
497965011502	putative active site [active]
497965011503	transaldolase; Provisional; Region: PRK03903
497965011504	catalytic residue [active]
497965011505	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
497965011506	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
497965011507	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
497965011508	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
497965011509	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
497965011510	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
497965011511	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
497965011512	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
497965011513	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
497965011514	catalytic triad [active]
497965011515	S-layer homology domain; Region: SLH; pfam00395
497965011516	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
497965011517	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
497965011518	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
497965011519	dimer interface [polypeptide binding]; other site
497965011520	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965011521	catalytic residue [active]
497965011522	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
497965011523	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965011524	HSP70 interaction site [polypeptide binding]; other site
497965011525	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
497965011526	active site
497965011527	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
497965011528	active site
497965011529	PAS fold; Region: PAS_4; pfam08448
497965011530	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965011531	putative active site [active]
497965011532	heme pocket [chemical binding]; other site
497965011533	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965011534	GAF domain; Region: GAF_2; pfam13185
497965011535	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965011536	dimer interface [polypeptide binding]; other site
497965011537	phosphorylation site [posttranslational modification]
497965011538	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965011539	ATP binding site [chemical binding]; other site
497965011540	Mg2+ binding site [ion binding]; other site
497965011541	G-X-G motif; other site
497965011542	Response regulator receiver domain; Region: Response_reg; pfam00072
497965011543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965011544	active site
497965011545	phosphorylation site [posttranslational modification]
497965011546	intermolecular recognition site; other site
497965011547	dimerization interface [polypeptide binding]; other site
497965011548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965011549	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965011550	active site
497965011551	phosphorylation site [posttranslational modification]
497965011552	intermolecular recognition site; other site
497965011553	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965011554	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965011555	PAS domain S-box; Region: sensory_box; TIGR00229
497965011556	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965011557	putative active site [active]
497965011558	heme pocket [chemical binding]; other site
497965011559	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965011560	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965011561	metal binding site [ion binding]; metal-binding site
497965011562	active site
497965011563	I-site; other site
497965011564	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965011565	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
497965011566	active site
497965011567	metal binding site [ion binding]; metal-binding site
497965011568	Cna protein B-type domain; Region: Cna_B; pfam05738
497965011569	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
497965011570	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
497965011571	active site
497965011572	zinc binding site [ion binding]; other site
497965011573	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
497965011574	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
497965011575	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
497965011576	Sm and related proteins; Region: Sm_like; cl00259
497965011577	heptamer interface [polypeptide binding]; other site
497965011578	Sm1 motif; other site
497965011579	hexamer interface [polypeptide binding]; other site
497965011580	RNA binding site [nucleotide binding]; other site
497965011581	Sm2 motif; other site
497965011582	Late competence development protein ComFB; Region: ComFB; pfam10719
497965011583	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
497965011584	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965011585	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965011586	DNA binding residues [nucleotide binding]
497965011587	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
497965011588	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
497965011589	putative active site pocket [active]
497965011590	dimerization interface [polypeptide binding]; other site
497965011591	putative catalytic residue [active]
497965011592	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
497965011593	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
497965011594	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
497965011595	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
497965011596	D-xylulose kinase; Region: XylB; TIGR01312
497965011597	nucleotide binding site [chemical binding]; other site
497965011598	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
497965011599	nudix motif; other site
497965011600	PIN domain; Region: PIN_3; cl17397
497965011601	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965011602	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
497965011603	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
497965011604	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
497965011605	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
497965011606	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
497965011607	Malic enzyme, N-terminal domain; Region: malic; pfam00390
497965011608	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
497965011609	putative NAD(P) binding site [chemical binding]; other site
497965011610	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
497965011611	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
497965011612	Uncharacterized conserved protein [Function unknown]; Region: COG4279
497965011613	SWIM zinc finger; Region: SWIM; pfam04434
497965011614	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
497965011615	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
497965011616	metal ion-dependent adhesion site (MIDAS); other site
497965011617	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
497965011618	Clp amino terminal domain; Region: Clp_N; pfam02861
497965011619	Clp amino terminal domain; Region: Clp_N; pfam02861
497965011620	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965011621	Walker A motif; other site
497965011622	ATP binding site [chemical binding]; other site
497965011623	Walker B motif; other site
497965011624	arginine finger; other site
497965011625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965011626	Walker A motif; other site
497965011627	ATP binding site [chemical binding]; other site
497965011628	Walker B motif; other site
497965011629	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
497965011630	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965011631	putative active site [active]
497965011632	stage V sporulation protein K; Region: spore_V_K; TIGR02881
497965011633	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965011634	Walker A motif; other site
497965011635	ATP binding site [chemical binding]; other site
497965011636	Walker B motif; other site
497965011637	arginine finger; other site
497965011638	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965011639	putative active site [active]
497965011640	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
497965011641	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
497965011642	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
497965011643	RNA binding site [nucleotide binding]; other site
497965011644	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
497965011645	RNA binding site [nucleotide binding]; other site
497965011646	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
497965011647	RNA binding site [nucleotide binding]; other site
497965011648	Dienelactone hydrolase family; Region: DLH; pfam01738
497965011649	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
497965011650	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
497965011651	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
497965011652	dimerization interface [polypeptide binding]; other site
497965011653	active site
497965011654	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
497965011655	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
497965011656	RNA binding surface [nucleotide binding]; other site
497965011657	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
497965011658	active site
497965011659	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
497965011660	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965011661	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965011662	Probable transposase; Region: OrfB_IS605; pfam01385
497965011663	YciI-like protein; Reviewed; Region: PRK12864
497965011664	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011665	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965011666	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011667	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011668	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
497965011669	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
497965011670	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
497965011671	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
497965011672	Coenzyme A binding pocket [chemical binding]; other site
497965011673	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
497965011674	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
497965011675	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
497965011676	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
497965011677	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
497965011678	AAA domain; Region: AAA_33; pfam13671
497965011679	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
497965011680	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
497965011681	active site
497965011682	SAM binding site [chemical binding]; other site
497965011683	homodimer interface [polypeptide binding]; other site
497965011684	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
497965011685	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
497965011686	active site
497965011687	Predicted ATPase [General function prediction only]; Region: COG4637
497965011688	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965011689	Walker A/P-loop; other site
497965011690	ATP binding site [chemical binding]; other site
497965011691	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
497965011692	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
497965011693	Ligand binding site; other site
497965011694	Putative Catalytic site; other site
497965011695	DXD motif; other site
497965011696	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
497965011697	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
497965011698	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
497965011699	RNA binding surface [nucleotide binding]; other site
497965011700	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
497965011701	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965011702	FeS/SAM binding site; other site
497965011703	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
497965011704	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
497965011705	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
497965011706	molybdopterin cofactor binding site; other site
497965011707	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
497965011708	molybdopterin cofactor binding site; other site
497965011709	PRC-barrel domain; Region: PRC; pfam05239
497965011710	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
497965011711	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965011712	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965011713	structural tetrad; other site
497965011714	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
497965011715	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497965011716	Soluble P-type ATPase [General function prediction only]; Region: COG4087
497965011717	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
497965011718	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
497965011719	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
497965011720	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
497965011721	Haemagglutinin; Region: Hemagglutinin; pfam00509
497965011722	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
497965011723	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
497965011724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
497965011725	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965011726	ABC-ATPase subunit interface; other site
497965011727	putative PBP binding loops; other site
497965011728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965011729	dimer interface [polypeptide binding]; other site
497965011730	conserved gate region; other site
497965011731	putative PBP binding loops; other site
497965011732	ABC-ATPase subunit interface; other site
497965011733	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965011734	non-specific DNA binding site [nucleotide binding]; other site
497965011735	salt bridge; other site
497965011736	sequence-specific DNA binding site [nucleotide binding]; other site
497965011737	CHAT domain; Region: CHAT; cl17868
497965011738	PBP superfamily domain; Region: PBP_like_2; pfam12849
497965011739	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
497965011740	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965011741	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011742	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011743	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011744	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011745	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965011746	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
497965011747	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
497965011748	substrate binding site [chemical binding]; other site
497965011749	cell division protein ZipA; Provisional; Region: PRK03427
497965011750	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
497965011751	HemN C-terminal domain; Region: HemN_C; pfam06969
497965011752	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
497965011753	heme binding pocket [chemical binding]; other site
497965011754	heme ligand [chemical binding]; other site
497965011755	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
497965011756	diiron binding motif [ion binding]; other site
497965011757	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
497965011758	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
497965011759	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
497965011760	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
497965011761	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
497965011762	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
497965011763	Surface antigen; Region: Bac_surface_Ag; pfam01103
497965011764	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
497965011765	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
497965011766	ATP binding site [chemical binding]; other site
497965011767	active site
497965011768	substrate binding site [chemical binding]; other site
497965011769	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
497965011770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965011771	dimer interface [polypeptide binding]; other site
497965011772	conserved gate region; other site
497965011773	putative PBP binding loops; other site
497965011774	ABC-ATPase subunit interface; other site
497965011775	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497965011776	active site
497965011777	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
497965011778	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
497965011779	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965011780	S-adenosylmethionine binding site [chemical binding]; other site
497965011781	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
497965011782	catalytic center binding site [active]
497965011783	ATP binding site [chemical binding]; other site
497965011784	anthranilate synthase component I-like protein; Validated; Region: PRK05940
497965011785	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
497965011786	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
497965011787	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
497965011788	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
497965011789	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
497965011790	NAD(P) binding site [chemical binding]; other site
497965011791	HEAT repeats; Region: HEAT_2; pfam13646
497965011792	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
497965011793	protein binding surface [polypeptide binding]; other site
497965011794	HEAT repeats; Region: HEAT_2; pfam13646
497965011795	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
497965011796	protein binding surface [polypeptide binding]; other site
497965011797	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
497965011798	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
497965011799	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
497965011800	protein binding surface [polypeptide binding]; other site
497965011801	PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130
497965011802	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
497965011803	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
497965011804	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
497965011805	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
497965011806	protein binding surface [polypeptide binding]; other site
497965011807	HEAT repeats; Region: HEAT_2; pfam13646
497965011808	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
497965011809	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
497965011810	HEAT repeats; Region: HEAT_2; pfam13646
497965011811	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
497965011812	protein binding surface [polypeptide binding]; other site
497965011813	HEAT repeats; Region: HEAT_2; pfam13646
497965011814	HEAT repeat; Region: HEAT; pfam02985
497965011815	HEAT repeats; Region: HEAT_2; pfam13646
497965011816	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
497965011817	Protein required for attachment to host cells; Region: Host_attach; pfam10116
497965011818	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
497965011819	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
497965011820	metal ion-dependent adhesion site (MIDAS); other site
497965011821	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
497965011822	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
497965011823	active site
497965011824	catalytic site [active]
497965011825	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
497965011826	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467
497965011827	starch-binding site 2 [chemical binding]; other site
497965011828	starch-binding site 1 [chemical binding]; other site
497965011829	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
497965011830	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
497965011831	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
497965011832	catalytic site [active]
497965011833	active site
497965011834	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
497965011835	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
497965011836	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
497965011837	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
497965011838	active site
497965011839	catalytic site [active]
497965011840	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
497965011841	Ferritin-like domain; Region: Ferritin; pfam00210
497965011842	dimanganese center [ion binding]; other site
497965011843	putative lipid kinase; Reviewed; Region: PRK00861
497965011844	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
497965011845	TPR repeat; Region: TPR_11; pfam13414
497965011846	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965011847	binding surface
497965011848	TPR motif; other site
497965011849	TPR repeat; Region: TPR_11; pfam13414
497965011850	Dynamin family; Region: Dynamin_N; pfam00350
497965011851	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
497965011852	G1 box; other site
497965011853	GTP/Mg2+ binding site [chemical binding]; other site
497965011854	Switch I region; other site
497965011855	G2 box; other site
497965011856	Switch II region; other site
497965011857	G3 box; other site
497965011858	G4 box; other site
497965011859	G5 box; other site
497965011860	Domain of unknown function (DUF697); Region: DUF697; pfam05128
497965011861	DevC protein; Region: devC; TIGR01185
497965011862	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
497965011863	FtsX-like permease family; Region: FtsX; pfam02687
497965011864	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
497965011865	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
497965011866	Walker A/P-loop; other site
497965011867	ATP binding site [chemical binding]; other site
497965011868	Q-loop/lid; other site
497965011869	ABC transporter signature motif; other site
497965011870	Walker B; other site
497965011871	D-loop; other site
497965011872	H-loop/switch region; other site
497965011873	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3398
497965011874	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
497965011875	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
497965011876	active site
497965011877	intersubunit interface [polypeptide binding]; other site
497965011878	catalytic residue [active]
497965011879	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
497965011880	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
497965011881	active site
497965011882	metal binding site [ion binding]; metal-binding site
497965011883	Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585
497965011884	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
497965011885	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
497965011886	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
497965011887	transmembrane helices; other site
497965011888	TrkA-C domain; Region: TrkA_C; pfam02080
497965011889	TrkA-C domain; Region: TrkA_C; pfam02080
497965011890	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
497965011891	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
497965011892	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
497965011893	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497965011894	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
497965011895	Soluble P-type ATPase [General function prediction only]; Region: COG4087
497965011896	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
497965011897	rod shape-determining protein MreD; Region: MreD; cl01087
497965011898	rod shape-determining protein MreC; Provisional; Region: PRK13922
497965011899	rod shape-determining protein MreC; Region: MreC; pfam04085
497965011900	rod shape-determining protein MreB; Provisional; Region: PRK13927
497965011901	MreB and similar proteins; Region: MreB_like; cd10225
497965011902	nucleotide binding site [chemical binding]; other site
497965011903	Mg binding site [ion binding]; other site
497965011904	putative protofilament interaction site [polypeptide binding]; other site
497965011905	RodZ interaction site [polypeptide binding]; other site
497965011906	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
497965011907	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
497965011908	dimer interface [polypeptide binding]; other site
497965011909	ssDNA binding site [nucleotide binding]; other site
497965011910	tetramer (dimer of dimers) interface [polypeptide binding]; other site
497965011911	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965011912	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
497965011913	putative ADP-binding pocket [chemical binding]; other site
497965011914	Bacterial sugar transferase; Region: Bac_transf; pfam02397
497965011915	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
497965011916	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
497965011917	NADP-binding site; other site
497965011918	homotetramer interface [polypeptide binding]; other site
497965011919	substrate binding site [chemical binding]; other site
497965011920	homodimer interface [polypeptide binding]; other site
497965011921	active site
497965011922	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
497965011923	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
497965011924	NADP binding site [chemical binding]; other site
497965011925	active site
497965011926	putative substrate binding site [chemical binding]; other site
497965011927	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
497965011928	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
497965011929	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
497965011930	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
497965011931	active site
497965011932	catalytic triad [active]
497965011933	dimer interface [polypeptide binding]; other site
497965011934	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
497965011935	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
497965011936	NAD(P) binding site [chemical binding]; other site
497965011937	catalytic residues [active]
497965011938	Mgc45594 gene product and other MDR family members; Region: Mgc45594_like; cd08250
497965011939	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
497965011940	NADP binding site [chemical binding]; other site
497965011941	dimer interface [polypeptide binding]; other site
497965011942	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
497965011943	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
497965011944	homotrimer interaction site [polypeptide binding]; other site
497965011945	putative active site [active]
497965011946	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965011947	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
497965011948	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965011949	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
497965011950	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
497965011951	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
497965011952	active site
497965011953	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
497965011954	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965011955	putative active site [active]
497965011956	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
497965011957	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
497965011958	active site
497965011959	PHP Thumb interface [polypeptide binding]; other site
497965011960	metal binding site [ion binding]; metal-binding site
497965011961	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
497965011962	protein-splicing catalytic site; other site
497965011963	thioester formation/cholesterol transfer; other site
497965011964	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
497965011965	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497965011966	substrate binding pocket [chemical binding]; other site
497965011967	membrane-bound complex binding site; other site
497965011968	hinge residues; other site
497965011969	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965011970	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
497965011971	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
497965011972	Cytochrome P450; Region: p450; cl12078
497965011973	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
497965011974	Cytochrome P450; Region: p450; cl12078
497965011975	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
497965011976	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
497965011977	active site
497965011978	catalytic tetrad [active]
497965011979	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
497965011980	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497965011981	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
497965011982	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
497965011983	active site
497965011984	Substrate binding site; other site
497965011985	Mg++ binding site; other site
497965011986	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
497965011987	putative trimer interface [polypeptide binding]; other site
497965011988	putative CoA binding site [chemical binding]; other site
497965011989	ScpA/B protein; Region: ScpA_ScpB; pfam02616
497965011990	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
497965011991	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
497965011992	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
497965011993	Creatinine amidohydrolase; Region: Creatininase; pfam02633
497965011994	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
497965011995	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
497965011996	active site
497965011997	catalytic triad [active]
497965011998	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
497965011999	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
497965012000	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
497965012001	dimer interface [polypeptide binding]; other site
497965012002	putative CheW interface [polypeptide binding]; other site
497965012003	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
497965012004	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497965012005	putative binding surface; other site
497965012006	active site
497965012007	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
497965012008	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965012009	ATP binding site [chemical binding]; other site
497965012010	Mg2+ binding site [ion binding]; other site
497965012011	G-X-G motif; other site
497965012012	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
497965012013	Response regulator receiver domain; Region: Response_reg; pfam00072
497965012014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965012015	active site
497965012016	phosphorylation site [posttranslational modification]
497965012017	intermolecular recognition site; other site
497965012018	dimerization interface [polypeptide binding]; other site
497965012019	CHASE3 domain; Region: CHASE3; cl05000
497965012020	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
497965012021	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
497965012022	dimer interface [polypeptide binding]; other site
497965012023	putative CheW interface [polypeptide binding]; other site
497965012024	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
497965012025	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
497965012026	dimer interface [polypeptide binding]; other site
497965012027	putative CheW interface [polypeptide binding]; other site
497965012028	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
497965012029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965012030	active site
497965012031	phosphorylation site [posttranslational modification]
497965012032	intermolecular recognition site; other site
497965012033	dimerization interface [polypeptide binding]; other site
497965012034	CheB methylesterase; Region: CheB_methylest; pfam01339
497965012035	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
497965012036	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
497965012037	TPR repeat; Region: TPR_11; pfam13414
497965012038	TPR repeat; Region: TPR_11; pfam13414
497965012039	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965012040	binding surface
497965012041	TPR motif; other site
497965012042	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965012043	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
497965012044	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
497965012045	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
497965012046	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
497965012047	putative acyl-acceptor binding pocket; other site
497965012048	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
497965012049	Protein of unknown function DUF58; Region: DUF58; pfam01882
497965012050	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
497965012051	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
497965012052	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
497965012053	active site
497965012054	catalytic residues [active]
497965012055	metal binding site [ion binding]; metal-binding site
497965012056	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
497965012057	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
497965012058	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497965012059	catalytic loop [active]
497965012060	iron binding site [ion binding]; other site
497965012061	Predicted methyltransferases [General function prediction only]; Region: COG0313
497965012062	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
497965012063	putative SAM binding site [chemical binding]; other site
497965012064	putative homodimer interface [polypeptide binding]; other site
497965012065	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
497965012066	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
497965012067	substrate binding site [chemical binding]; other site
497965012068	ATP binding site [chemical binding]; other site
497965012069	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
497965012070	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
497965012071	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
497965012072	putative active site [active]
497965012073	putative NTP binding site [chemical binding]; other site
497965012074	putative nucleic acid binding site [nucleotide binding]; other site
497965012075	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
497965012076	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965012077	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965012078	active site
497965012079	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
497965012080	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
497965012081	active site
497965012082	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
497965012083	N-acetyl-D-glucosamine binding site [chemical binding]; other site
497965012084	catalytic residue [active]
497965012085	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
497965012086	NADH(P)-binding; Region: NAD_binding_10; pfam13460
497965012087	NAD(P) binding site [chemical binding]; other site
497965012088	putative active site [active]
497965012089	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
497965012090	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
497965012091	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
497965012092	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497965012093	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
497965012094	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
497965012095	Soluble P-type ATPase [General function prediction only]; Region: COG4087
497965012096	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
497965012097	TIGR02588 family protein; Region: TIGR02588
497965012098	Protein of unknown function (DUF2393); Region: DUF2393; pfam09624
497965012099	Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622
497965012100	Uncharacterized conserved protein [Function unknown]; Region: COG3937
497965012101	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
497965012102	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
497965012103	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
497965012104	Predicted membrane protein [Function unknown]; Region: COG4244
497965012105	Predicted membrane protein [Function unknown]; Region: COG4244
497965012106	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
497965012107	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
497965012108	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
497965012109	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
497965012110	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
497965012111	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
497965012112	Subunit I/III interface [polypeptide binding]; other site
497965012113	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
497965012114	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
497965012115	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
497965012116	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
497965012117	putative NAD(P) binding site [chemical binding]; other site
497965012118	catalytic Zn binding site [ion binding]; other site
497965012119	structural Zn binding site [ion binding]; other site
497965012120	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
497965012121	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
497965012122	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
497965012123	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965012124	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
497965012125	ligand binding site [chemical binding]; other site
497965012126	flexible hinge region; other site
497965012127	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
497965012128	putative switch regulator; other site
497965012129	non-specific DNA interactions [nucleotide binding]; other site
497965012130	DNA binding site [nucleotide binding]
497965012131	sequence specific DNA binding site [nucleotide binding]; other site
497965012132	putative cAMP binding site [chemical binding]; other site
497965012133	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
497965012134	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
497965012135	NAD binding site [chemical binding]; other site
497965012136	homotetramer interface [polypeptide binding]; other site
497965012137	homodimer interface [polypeptide binding]; other site
497965012138	substrate binding site [chemical binding]; other site
497965012139	active site
497965012140	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965012141	putative active site [active]
497965012142	Predicted membrane protein [Function unknown]; Region: COG1950
497965012143	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
497965012144	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
497965012145	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
497965012146	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
497965012147	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
497965012148	active site
497965012149	SAM binding site [chemical binding]; other site
497965012150	homodimer interface [polypeptide binding]; other site
497965012151	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
497965012152	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
497965012153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965012154	S-adenosylmethionine binding site [chemical binding]; other site
497965012155	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
497965012156	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
497965012157	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
497965012158	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
497965012159	B12 binding site [chemical binding]; other site
497965012160	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965012161	FeS/SAM binding site; other site
497965012162	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
497965012163	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
497965012164	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
497965012165	anti sigma factor interaction site; other site
497965012166	regulatory phosphorylation site [posttranslational modification]; other site
497965012167	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
497965012168	nucleotide binding site/active site [active]
497965012169	HIT family signature motif; other site
497965012170	catalytic residue [active]
497965012171	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
497965012172	catalytic motif [active]
497965012173	Catalytic residue [active]
497965012174	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965012175	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
497965012176	putative ADP-binding pocket [chemical binding]; other site
497965012177	TPR repeat; Region: TPR_11; pfam13414
497965012178	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
497965012179	HEAT repeats; Region: HEAT_2; pfam13646
497965012180	protein binding surface [polypeptide binding]; other site
497965012181	L-aspartate oxidase; Provisional; Region: PRK07395
497965012182	L-aspartate oxidase; Provisional; Region: PRK06175
497965012183	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
497965012184	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
497965012185	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
497965012186	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
497965012187	dimer interface [polypeptide binding]; other site
497965012188	decamer (pentamer of dimers) interface [polypeptide binding]; other site
497965012189	catalytic triad [active]
497965012190	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
497965012191	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
497965012192	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
497965012193	putative active site [active]
497965012194	catalytic site [active]
497965012195	Domon-like ligand-binding domains; Region: DOMON_like; cd00241
497965012196	putative ligand binding site [chemical binding]; other site
497965012197	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965012198	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965012199	phosphopeptide binding site; other site
497965012200	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965012201	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965012202	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965012203	dimer interface [polypeptide binding]; other site
497965012204	phosphorylation site [posttranslational modification]
497965012205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965012206	ATP binding site [chemical binding]; other site
497965012207	Mg2+ binding site [ion binding]; other site
497965012208	G-X-G motif; other site
497965012209	Response regulator receiver domain; Region: Response_reg; pfam00072
497965012210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965012211	active site
497965012212	phosphorylation site [posttranslational modification]
497965012213	intermolecular recognition site; other site
497965012214	dimerization interface [polypeptide binding]; other site
497965012215	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
497965012216	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
497965012217	active site
497965012218	dimer interface [polypeptide binding]; other site
497965012219	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
497965012220	dimer interface [polypeptide binding]; other site
497965012221	active site
497965012222	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
497965012223	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
497965012224	NAD binding site [chemical binding]; other site
497965012225	dimer interface [polypeptide binding]; other site
497965012226	substrate binding site [chemical binding]; other site
497965012227	tetramer (dimer of dimers) interface [polypeptide binding]; other site
497965012228	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
497965012229	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
497965012230	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
497965012231	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
497965012232	G1 box; other site
497965012233	GTP/Mg2+ binding site [chemical binding]; other site
497965012234	G2 box; other site
497965012235	Switch I region; other site
497965012236	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
497965012237	Dynamin family; Region: Dynamin_N; pfam00350
497965012238	G1 box; other site
497965012239	GTP/Mg2+ binding site [chemical binding]; other site
497965012240	G2 box; other site
497965012241	Switch I region; other site
497965012242	G3 box; other site
497965012243	Switch II region; other site
497965012244	G4 box; other site
497965012245	G5 box; other site
497965012246	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
497965012247	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
497965012248	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
497965012249	nucleotide binding site [chemical binding]; other site
497965012250	putative NEF/HSP70 interaction site [polypeptide binding]; other site
497965012251	SBD interface [polypeptide binding]; other site
497965012252	Right handed beta helix region; Region: Beta_helix; pfam13229
497965012253	Right handed beta helix region; Region: Beta_helix; pfam13229
497965012254	Right handed beta helix region; Region: Beta_helix; pfam13229
497965012255	Right handed beta helix region; Region: Beta_helix; pfam13229
497965012256	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
497965012257	putative phosphoketolase; Provisional; Region: PRK05261
497965012258	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
497965012259	TPP-binding site; other site
497965012260	XFP C-terminal domain; Region: XFP_C; pfam09363
497965012261	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
497965012262	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
497965012263	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
497965012264	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965012265	TPR motif; other site
497965012266	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965012267	binding surface
497965012268	Tetratricopeptide repeat; Region: TPR_16; pfam13432
497965012269	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
497965012270	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
497965012271	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
497965012272	putative active site [active]
497965012273	putative substrate binding site [chemical binding]; other site
497965012274	putative cosubstrate binding site; other site
497965012275	catalytic site [active]
497965012276	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
497965012277	Protein of unknown function (DUF790); Region: DUF790; pfam05626
497965012278	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965012279	TPR repeat; Region: TPR_11; pfam13414
497965012280	binding surface
497965012281	TPR motif; other site
497965012282	TPR repeat; Region: TPR_11; pfam13414
497965012283	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965012284	binding surface
497965012285	TPR repeat; Region: TPR_11; pfam13414
497965012286	TPR motif; other site
497965012287	Tetratricopeptide repeat; Region: TPR_16; pfam13432
497965012288	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965012289	binding surface
497965012290	TPR motif; other site
497965012291	Tetratricopeptide repeat; Region: TPR_16; pfam13432
497965012292	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
497965012293	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965012294	P-loop; other site
497965012295	Magnesium ion binding site [ion binding]; other site
497965012296	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
497965012297	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
497965012298	Rubredoxin [Energy production and conversion]; Region: COG1773
497965012299	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
497965012300	iron binding site [ion binding]; other site
497965012301	Ycf48-like protein; Provisional; Region: PRK13684
497965012302	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
497965012303	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
497965012304	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
497965012305	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
497965012306	photosystem II reaction center L; Provisional; Region: psbL; PRK00753
497965012307	Predicted membrane protein [Function unknown]; Region: COG2246
497965012308	GtrA-like protein; Region: GtrA; pfam04138
497965012309	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
497965012310	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
497965012311	Ligand binding site; other site
497965012312	Putative Catalytic site; other site
497965012313	DXD motif; other site
497965012314	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
497965012315	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
497965012316	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
497965012317	catalytic residues [active]
497965012318	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965012319	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965012320	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965012321	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965012322	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965012323	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965012324	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965012325	active site
497965012326	ATP binding site [chemical binding]; other site
497965012327	substrate binding site [chemical binding]; other site
497965012328	activation loop (A-loop); other site
497965012329	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
497965012330	SdiA-regulated; Region: SdiA-regulated; cd09971
497965012331	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965012332	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965012333	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965012334	active site
497965012335	phosphorylation site [posttranslational modification]
497965012336	intermolecular recognition site; other site
497965012337	dimerization interface [polypeptide binding]; other site
497965012338	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965012339	DNA binding residues [nucleotide binding]
497965012340	dimerization interface [polypeptide binding]; other site
497965012341	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965012342	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
497965012343	dimer interface [polypeptide binding]; other site
497965012344	phosphorylation site [posttranslational modification]
497965012345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965012346	ATP binding site [chemical binding]; other site
497965012347	Mg2+ binding site [ion binding]; other site
497965012348	G-X-G motif; other site
497965012349	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
497965012350	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
497965012351	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
497965012352	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
497965012353	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
497965012354	PAAR motif; Region: PAAR_motif; pfam05488
497965012355	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
497965012356	active site flap/lid [active]
497965012357	nucleophilic elbow; other site
497965012358	catalytic triad [active]
497965012359	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
497965012360	heterotetramer interface [polypeptide binding]; other site
497965012361	active site pocket [active]
497965012362	cleavage site
497965012363	Protein of unknown function (DUF433); Region: DUF433; pfam04255
497965012364	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965012365	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965012366	active site
497965012367	ATP binding site [chemical binding]; other site
497965012368	substrate binding site [chemical binding]; other site
497965012369	activation loop (A-loop); other site
497965012370	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965012371	structural tetrad; other site
497965012372	PQQ-like domain; Region: PQQ_2; pfam13360
497965012373	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
497965012374	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497965012375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965012376	S-adenosylmethionine binding site [chemical binding]; other site
497965012377	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
497965012378	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
497965012379	GatB domain; Region: GatB_Yqey; smart00845
497965012380	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
497965012381	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
497965012382	ligand binding site; other site
497965012383	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
497965012384	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
497965012385	B12 binding site [chemical binding]; other site
497965012386	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965012387	FeS/SAM binding site; other site
497965012388	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
497965012389	hypothetical protein; Provisional; Region: PRK07338
497965012390	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
497965012391	metal binding site [ion binding]; metal-binding site
497965012392	dimer interface [polypeptide binding]; other site
497965012393	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
497965012394	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
497965012395	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
497965012396	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
497965012397	EamA-like transporter family; Region: EamA; cl17759
497965012398	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
497965012399	dinuclear metal binding motif [ion binding]; other site
497965012400	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
497965012401	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
497965012402	putative NAD(P) binding site [chemical binding]; other site
497965012403	Uncharacterized conserved protein [Function unknown]; Region: COG1262
497965012404	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
497965012405	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
497965012406	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
497965012407	ABC-ATPase subunit  interface; other site
497965012408	dimer interface [polypeptide binding]; other site
497965012409	putative PBP binding regions; other site
497965012410	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
497965012411	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
497965012412	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
497965012413	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
497965012414	intersubunit interface [polypeptide binding]; other site
497965012415	muropeptide transporter; Validated; Region: ampG; cl17669
497965012416	muropeptide transporter; Reviewed; Region: ampG; PRK11902
497965012417	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497965012418	catalytic core [active]
497965012419	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
497965012420	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
497965012421	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
497965012422	putative catalytic residue [active]
497965012423	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965012424	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965012425	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
497965012426	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965012427	motif II; other site
497965012428	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
497965012429	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
497965012430	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
497965012431	SnoaL-like domain; Region: SnoaL_2; pfam12680
497965012432	Transposase; Region: DEDD_Tnp_IS110; pfam01548
497965012433	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
497965012434	endonuclease III; Region: ENDO3c; smart00478
497965012435	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965012436	non-specific DNA binding site [nucleotide binding]; other site
497965012437	salt bridge; other site
497965012438	sequence-specific DNA binding site [nucleotide binding]; other site
497965012439	enoyl-CoA hydratase; Provisional; Region: PRK06072
497965012440	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965012441	active site
497965012442	catalytic residues [active]
497965012443	DNA binding site [nucleotide binding]
497965012444	Int/Topo IB signature motif; other site
497965012445	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
497965012446	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
497965012447	active site
497965012448	HIGH motif; other site
497965012449	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
497965012450	KMSKS motif; other site
497965012451	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
497965012452	tRNA binding surface [nucleotide binding]; other site
497965012453	anticodon binding site; other site
497965012454	Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628
497965012455	5' RNA guide strand anchoring site; other site
497965012456	active site
497965012457	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965012458	Lipase (class 2); Region: Lipase_2; pfam01674
497965012459	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965012460	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
497965012461	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
497965012462	NAD(P) binding site [chemical binding]; other site
497965012463	catalytic residues [active]
497965012464	prolyl-tRNA synthetase; Provisional; Region: PRK09194
497965012465	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
497965012466	dimer interface [polypeptide binding]; other site
497965012467	motif 1; other site
497965012468	active site
497965012469	motif 2; other site
497965012470	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
497965012471	putative deacylase active site [active]
497965012472	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
497965012473	active site
497965012474	motif 3; other site
497965012475	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
497965012476	anticodon binding site; other site
497965012477	Late competence development protein ComFB; Region: ComFB; pfam10719
497965012478	Late competence development protein ComFB; Region: ComFB; pfam10719
497965012479	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
497965012480	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
497965012481	putative active site [active]
497965012482	Zn binding site [ion binding]; other site
497965012483	hypothetical protein; Reviewed; Region: PRK00024
497965012484	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
497965012485	MPN+ (JAMM) motif; other site
497965012486	Zinc-binding site [ion binding]; other site
497965012487	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
497965012488	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965012489	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
497965012490	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965012491	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
497965012492	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
497965012493	G1 box; other site
497965012494	putative GEF interaction site [polypeptide binding]; other site
497965012495	GTP/Mg2+ binding site [chemical binding]; other site
497965012496	Switch I region; other site
497965012497	G2 box; other site
497965012498	G3 box; other site
497965012499	Switch II region; other site
497965012500	G4 box; other site
497965012501	G5 box; other site
497965012502	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
497965012503	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965012504	non-specific DNA binding site [nucleotide binding]; other site
497965012505	salt bridge; other site
497965012506	sequence-specific DNA binding site [nucleotide binding]; other site
497965012507	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
497965012508	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
497965012509	ParB-like nuclease domain; Region: ParBc; cl02129
497965012510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965012511	Response regulator receiver domain; Region: Response_reg; pfam00072
497965012512	active site
497965012513	phosphorylation site [posttranslational modification]
497965012514	intermolecular recognition site; other site
497965012515	dimerization interface [polypeptide binding]; other site
497965012516	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
497965012517	Response regulator receiver domain; Region: Response_reg; pfam00072
497965012518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965012519	active site
497965012520	phosphorylation site [posttranslational modification]
497965012521	intermolecular recognition site; other site
497965012522	dimerization interface [polypeptide binding]; other site
497965012523	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
497965012524	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
497965012525	Walker A/P-loop; other site
497965012526	ATP binding site [chemical binding]; other site
497965012527	Q-loop/lid; other site
497965012528	ABC transporter signature motif; other site
497965012529	Walker B; other site
497965012530	D-loop; other site
497965012531	H-loop/switch region; other site
497965012532	EcsC protein family; Region: EcsC; pfam12787
497965012533	Response regulator receiver domain; Region: Response_reg; pfam00072
497965012534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965012535	active site
497965012536	phosphorylation site [posttranslational modification]
497965012537	intermolecular recognition site; other site
497965012538	dimerization interface [polypeptide binding]; other site
497965012539	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965012540	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965012541	metal binding site [ion binding]; metal-binding site
497965012542	active site
497965012543	I-site; other site
497965012544	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
497965012545	nudix motif; other site
497965012546	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
497965012547	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
497965012548	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
497965012549	trimer interface [polypeptide binding]; other site
497965012550	dimer interface [polypeptide binding]; other site
497965012551	putative active site [active]
497965012552	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
497965012553	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
497965012554	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
497965012555	N-acetyl-D-glucosamine binding site [chemical binding]; other site
497965012556	catalytic residue [active]
497965012557	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
497965012558	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
497965012559	PhoH-like protein; Region: PhoH; cl17668
497965012560	Family description; Region: UvrD_C_2; pfam13538
497965012561	Prophage antirepressor [Transcription]; Region: COG3617
497965012562	BRO family, N-terminal domain; Region: Bro-N; smart01040
497965012563	Prophage antirepressor [Transcription]; Region: COG3617
497965012564	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
497965012565	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965012566	active site
497965012567	catalytic residues [active]
497965012568	DNA binding site [nucleotide binding]
497965012569	Int/Topo IB signature motif; other site
497965012570	Right handed beta helix region; Region: Beta_helix; pfam13229
497965012571	Disaggregatase related; Region: Disaggr_assoc; pfam08480
497965012572	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
497965012573	ResB-like family; Region: ResB; pfam05140
497965012574	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
497965012575	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
497965012576	methionine sulfoxide reductase A; Provisional; Region: PRK00058
497965012577	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
497965012578	GAF domain; Region: GAF; pfam01590
497965012579	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965012580	GAF domain; Region: GAF_3; pfam13492
497965012581	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965012582	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965012583	dimer interface [polypeptide binding]; other site
497965012584	phosphorylation site [posttranslational modification]
497965012585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965012586	ATP binding site [chemical binding]; other site
497965012587	Mg2+ binding site [ion binding]; other site
497965012588	G-X-G motif; other site
497965012589	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
497965012590	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
497965012591	acyl-activating enzyme (AAE) consensus motif; other site
497965012592	putative AMP binding site [chemical binding]; other site
497965012593	putative active site [active]
497965012594	putative CoA binding site [chemical binding]; other site
497965012595	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965012596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965012597	active site
497965012598	phosphorylation site [posttranslational modification]
497965012599	intermolecular recognition site; other site
497965012600	dimerization interface [polypeptide binding]; other site
497965012601	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965012602	DNA binding site [nucleotide binding]
497965012603	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
497965012604	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
497965012605	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
497965012606	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
497965012607	FtsX-like permease family; Region: FtsX; pfam02687
497965012608	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
497965012609	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497965012610	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965012611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965012612	binding surface
497965012613	TPR motif; other site
497965012614	TPR repeat; Region: TPR_11; pfam13414
497965012615	TPR repeat; Region: TPR_11; pfam13414
497965012616	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965012617	binding surface
497965012618	TPR motif; other site
497965012619	TPR repeat; Region: TPR_11; pfam13414
497965012620	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965012621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965012622	active site
497965012623	phosphorylation site [posttranslational modification]
497965012624	intermolecular recognition site; other site
497965012625	dimerization interface [polypeptide binding]; other site
497965012626	DNA gyrase, A subunit; Region: gyrA; TIGR01063
497965012627	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
497965012628	CAP-like domain; other site
497965012629	active site
497965012630	primary dimer interface [polypeptide binding]; other site
497965012631	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497965012632	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497965012633	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497965012634	Uncharacterized conserved protein [Function unknown]; Region: COG1434
497965012635	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
497965012636	putative active site [active]
497965012637	Pirin-related protein [General function prediction only]; Region: COG1741
497965012638	Pirin; Region: Pirin; pfam02678
497965012639	Predicted transcriptional regulators [Transcription]; Region: COG1733
497965012640	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497965012641	dimerization interface [polypeptide binding]; other site
497965012642	putative DNA binding site [nucleotide binding]; other site
497965012643	putative Zn2+ binding site [ion binding]; other site
497965012644	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
497965012645	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
497965012646	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
497965012647	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965012648	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497965012649	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
497965012650	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
497965012651	catalytic residues [active]
497965012652	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
497965012653	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
497965012654	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
497965012655	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497965012656	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
497965012657	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
497965012658	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
497965012659	putative acyl-acceptor binding pocket; other site
497965012660	Cache domain; Region: Cache_1; pfam02743
497965012661	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965012662	dimerization interface [polypeptide binding]; other site
497965012663	PAS fold; Region: PAS_4; pfam08448
497965012664	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965012665	putative active site [active]
497965012666	heme pocket [chemical binding]; other site
497965012667	PAS domain S-box; Region: sensory_box; TIGR00229
497965012668	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965012669	putative active site [active]
497965012670	heme pocket [chemical binding]; other site
497965012671	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965012672	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965012673	metal binding site [ion binding]; metal-binding site
497965012674	active site
497965012675	I-site; other site
497965012676	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
497965012677	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
497965012678	putative catalytic residues [active]
497965012679	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
497965012680	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
497965012681	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
497965012682	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
497965012683	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
497965012684	ligand binding site [chemical binding]; other site
497965012685	homodimer interface [polypeptide binding]; other site
497965012686	NAD(P) binding site [chemical binding]; other site
497965012687	trimer interface B [polypeptide binding]; other site
497965012688	trimer interface A [polypeptide binding]; other site
497965012689	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
497965012690	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
497965012691	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965012692	putative active site [active]
497965012693	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
497965012694	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
497965012695	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
497965012696	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
497965012697	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
497965012698	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
497965012699	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497965012700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965012701	S-adenosylmethionine binding site [chemical binding]; other site
497965012702	hypothetical protein; Validated; Region: PRK00153
497965012703	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
497965012704	FAD binding domain; Region: FAD_binding_4; pfam01565
497965012705	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
497965012706	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
497965012707	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
497965012708	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
497965012709	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
497965012710	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
497965012711	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
497965012712	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
497965012713	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
497965012714	active site
497965012715	metal binding site [ion binding]; metal-binding site
497965012716	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965012717	AAA domain; Region: AAA_21; pfam13304
497965012718	Walker A/P-loop; other site
497965012719	ATP binding site [chemical binding]; other site
497965012720	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965012721	Walker B; other site
497965012722	D-loop; other site
497965012723	H-loop/switch region; other site
497965012724	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
497965012725	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
497965012726	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
497965012727	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
497965012728	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
497965012729	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
497965012730	iron-sulfur cluster [ion binding]; other site
497965012731	[2Fe-2S] cluster binding site [ion binding]; other site
497965012732	Rubrerythrin [Energy production and conversion]; Region: COG1592
497965012733	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
497965012734	binuclear metal center [ion binding]; other site
497965012735	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965012736	dimer interface [polypeptide binding]; other site
497965012737	phosphorylation site [posttranslational modification]
497965012738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965012739	ATP binding site [chemical binding]; other site
497965012740	Mg2+ binding site [ion binding]; other site
497965012741	G-X-G motif; other site
497965012742	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965012743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965012744	active site
497965012745	phosphorylation site [posttranslational modification]
497965012746	intermolecular recognition site; other site
497965012747	dimerization interface [polypeptide binding]; other site
497965012748	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965012749	DNA binding site [nucleotide binding]
497965012750	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
497965012751	S-layer homology domain; Region: SLH; pfam00395
497965012752	S-layer homology domain; Region: SLH; pfam00395
497965012753	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
497965012754	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965012755	Coenzyme A binding pocket [chemical binding]; other site
497965012756	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
497965012757	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497965012758	DRTGG domain; Region: DRTGG; pfam07085
497965012759	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
497965012760	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
497965012761	FMN binding site [chemical binding]; other site
497965012762	active site
497965012763	catalytic residues [active]
497965012764	substrate binding site [chemical binding]; other site
497965012765	TPR repeat; Region: TPR_11; pfam13414
497965012766	TPR repeat; Region: TPR_11; pfam13414
497965012767	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965012768	binding surface
497965012769	TPR motif; other site
497965012770	TPR repeat; Region: TPR_11; pfam13414
497965012771	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965012772	binding surface
497965012773	TPR motif; other site
497965012774	TPR repeat; Region: TPR_11; pfam13414
497965012775	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965012776	binding surface
497965012777	TPR motif; other site
497965012778	TPR repeat; Region: TPR_11; pfam13414
497965012779	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965012780	TPR motif; other site
497965012781	TPR repeat; Region: TPR_11; pfam13414
497965012782	binding surface
497965012783	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
497965012784	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965012785	Walker A/P-loop; other site
497965012786	ATP binding site [chemical binding]; other site
497965012787	Q-loop/lid; other site
497965012788	ABC transporter signature motif; other site
497965012789	Walker B; other site
497965012790	D-loop; other site
497965012791	H-loop/switch region; other site
497965012792	TOBE domain; Region: TOBE_2; pfam08402
497965012793	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
497965012794	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
497965012795	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
497965012796	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
497965012797	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
497965012798	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
497965012799	N-acetyl-D-glucosamine binding site [chemical binding]; other site
497965012800	catalytic residue [active]
497965012801	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
497965012802	heat shock protein 90; Provisional; Region: PRK05218
497965012803	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965012804	ATP binding site [chemical binding]; other site
497965012805	Mg2+ binding site [ion binding]; other site
497965012806	G-X-G motif; other site
497965012807	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
497965012808	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
497965012809	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
497965012810	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
497965012811	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
497965012812	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
497965012813	ring oligomerisation interface [polypeptide binding]; other site
497965012814	ATP/Mg binding site [chemical binding]; other site
497965012815	stacking interactions; other site
497965012816	hinge regions; other site
497965012817	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
497965012818	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
497965012819	NAD(P) binding site [chemical binding]; other site
497965012820	homotetramer interface [polypeptide binding]; other site
497965012821	homodimer interface [polypeptide binding]; other site
497965012822	active site
497965012823	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965012824	Probable transposase; Region: OrfB_IS605; pfam01385
497965012825	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965012826	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965012827	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965012828	dimerization interface [polypeptide binding]; other site
497965012829	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965012830	dimer interface [polypeptide binding]; other site
497965012831	phosphorylation site [posttranslational modification]
497965012832	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965012833	ATP binding site [chemical binding]; other site
497965012834	Mg2+ binding site [ion binding]; other site
497965012835	G-X-G motif; other site
497965012836	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965012837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965012838	active site
497965012839	phosphorylation site [posttranslational modification]
497965012840	intermolecular recognition site; other site
497965012841	dimerization interface [polypeptide binding]; other site
497965012842	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965012843	DNA binding site [nucleotide binding]
497965012844	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
497965012845	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965012846	non-specific DNA binding site [nucleotide binding]; other site
497965012847	salt bridge; other site
497965012848	sequence-specific DNA binding site [nucleotide binding]; other site
497965012849	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
497965012850	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965012851	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
497965012852	DDE superfamily endonuclease; Region: DDE_5; cl17874
497965012853	TIR domain; Region: TIR_2; cl17458
497965012854	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
497965012855	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
497965012856	AAA domain; Region: AAA_25; pfam13481
497965012857	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497965012858	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965012859	non-specific DNA binding site [nucleotide binding]; other site
497965012860	salt bridge; other site
497965012861	sequence-specific DNA binding site [nucleotide binding]; other site
497965012862	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
497965012863	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
497965012864	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
497965012865	active site
497965012866	catalytic site [active]
497965012867	substrate binding site [chemical binding]; other site
497965012868	rod shape-determining protein MreC; Provisional; Region: PRK13922
497965012869	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
497965012870	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965012871	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
497965012872	Response regulator receiver domain; Region: Response_reg; pfam00072
497965012873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965012874	active site
497965012875	phosphorylation site [posttranslational modification]
497965012876	intermolecular recognition site; other site
497965012877	dimerization interface [polypeptide binding]; other site
497965012878	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965012879	GAF domain; Region: GAF; pfam01590
497965012880	Haemolytic domain; Region: Haemolytic; pfam01809
497965012881	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
497965012882	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
497965012883	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
497965012884	Subunit I/III interface [polypeptide binding]; other site
497965012885	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
497965012886	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
497965012887	D-pathway; other site
497965012888	Putative ubiquinol binding site [chemical binding]; other site
497965012889	Low-spin heme (heme b) binding site [chemical binding]; other site
497965012890	Putative water exit pathway; other site
497965012891	Binuclear center (heme o3/CuB) [ion binding]; other site
497965012892	K-pathway; other site
497965012893	Putative proton exit pathway; other site
497965012894	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
497965012895	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
497965012896	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
497965012897	proton extrusion protein PcxA; Provisional; Region: PRK02507
497965012898	Protein of unknown function (DUF760); Region: DUF760; pfam05542
497965012899	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
497965012900	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
497965012901	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497965012902	dimerization interface [polypeptide binding]; other site
497965012903	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
497965012904	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497965012905	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497965012906	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
497965012907	ADP-ribose binding site [chemical binding]; other site
497965012908	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
497965012909	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
497965012910	HflX GTPase family; Region: HflX; cd01878
497965012911	G1 box; other site
497965012912	GTP/Mg2+ binding site [chemical binding]; other site
497965012913	Switch I region; other site
497965012914	G2 box; other site
497965012915	G3 box; other site
497965012916	Switch II region; other site
497965012917	G4 box; other site
497965012918	G5 box; other site
497965012919	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
497965012920	MoxR-like ATPases [General function prediction only]; Region: COG0714
497965012921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
497965012922	ATP binding site [chemical binding]; other site
497965012923	Walker B motif; other site
497965012924	arginine finger; other site
497965012925	glycogen synthase; Provisional; Region: glgA; PRK00654
497965012926	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
497965012927	ADP-binding pocket [chemical binding]; other site
497965012928	homodimer interface [polypeptide binding]; other site
497965012929	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
497965012930	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
497965012931	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
497965012932	catalytic motif [active]
497965012933	Catalytic residue [active]
497965012934	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
497965012935	dimer interface [polypeptide binding]; other site
497965012936	motif 1; other site
497965012937	active site
497965012938	motif 2; other site
497965012939	motif 3; other site
497965012940	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
497965012941	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
497965012942	putative active site [active]
497965012943	Zn binding site [ion binding]; other site
497965012944	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
497965012945	RimK-like ATP-grasp domain; Region: RimK; pfam08443
497965012946	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
497965012947	Cytochrome c; Region: Cytochrom_C; pfam00034
497965012948	cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665
497965012949	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
497965012950	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
497965012951	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
497965012952	phosphate binding site [ion binding]; other site
497965012953	putative substrate binding pocket [chemical binding]; other site
497965012954	dimer interface [polypeptide binding]; other site
497965012955	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
497965012956	EamA-like transporter family; Region: EamA; pfam00892
497965012957	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
497965012958	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
497965012959	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
497965012960	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497965012961	catalytic residue [active]
497965012962	DGQHR domain; Region: DGQHR; TIGR03187
497965012963	DNA-sulfur modification-associated; Region: DndB; cl17621
497965012964	DNA-sulfur modification-associated; Region: DndB; pfam14072
497965012965	DGQHR domain; Region: DGQHR; TIGR03187
497965012966	Uncharacterized conserved protein [Function unknown]; Region: COG5464
497965012967	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
497965012968	DNA-sulfur modification-associated; Region: DndB; pfam14072
497965012969	hypothetical protein; Provisional; Region: PRK06850
497965012970	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
497965012971	Active Sites [active]
497965012972	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
497965012973	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
497965012974	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
497965012975	short chain dehydrogenase; Provisional; Region: PRK06181
497965012976	NADP binding site [chemical binding]; other site
497965012977	homodimer interface [polypeptide binding]; other site
497965012978	substrate binding site [chemical binding]; other site
497965012979	active site
497965012980	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
497965012981	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965012982	Walker A/P-loop; other site
497965012983	ATP binding site [chemical binding]; other site
497965012984	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965012985	ABC transporter signature motif; other site
497965012986	Walker B; other site
497965012987	D-loop; other site
497965012988	H-loop/switch region; other site
497965012989	GUN4-like; Region: GUN4; pfam05419
497965012990	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
497965012991	PRC-barrel domain; Region: PRC; pfam05239
497965012992	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
497965012993	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
497965012994	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
497965012995	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
497965012996	Amidase; Region: Amidase; pfam01425
497965012997	Protein of unknown function (DUF552); Region: DUF552; pfam04472
497965012998	Predicted membrane protein [Function unknown]; Region: COG1950
497965012999	CoA binding domain; Region: CoA_binding; cl17356
497965013000	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013001	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013002	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
497965013003	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
497965013004	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
497965013005	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
497965013006	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
497965013007	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
497965013008	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
497965013009	ABC-ATPase subunit  interface; other site
497965013010	dimer interface [polypeptide binding]; other site
497965013011	putative PBP binding regions; other site
497965013012	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
497965013013	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
497965013014	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
497965013015	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
497965013016	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
497965013017	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
497965013018	metal binding site [ion binding]; metal-binding site
497965013019	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965013020	putative active site [active]
497965013021	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
497965013022	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
497965013023	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
497965013024	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
497965013025	DNA binding residues [nucleotide binding]
497965013026	putative dimer interface [polypeptide binding]; other site
497965013027	Domain of unknown function (DUF4297); Region: DUF4297; pfam14130
497965013028	Bacterial TniB protein; Region: TniB; pfam05621
497965013029	AAA domain; Region: AAA_22; pfam13401
497965013030	Helix-turn-helix domain; Region: HTH_28; pfam13518
497965013031	Winged helix-turn helix; Region: HTH_29; pfam13551
497965013032	Homeodomain-like domain; Region: HTH_32; pfam13565
497965013033	Integrase core domain; Region: rve; pfam00665
497965013034	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
497965013035	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013036	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013037	binding surface
497965013038	TPR motif; other site
497965013039	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013040	CHAT domain; Region: CHAT; pfam12770
497965013041	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
497965013042	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013043	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
497965013045	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
497965013046	haemagglutination activity domain; Region: Haemagg_act; pfam05860
497965013047	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
497965013048	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
497965013049	active site
497965013050	catalytic residues [active]
497965013051	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
497965013052	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
497965013053	Surface antigen; Region: Bac_surface_Ag; pfam01103
497965013054	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
497965013055	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
497965013056	CHASE2 domain; Region: CHASE2; pfam05226
497965013057	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
497965013058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
497965013059	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
497965013060	Methyltransferase domain; Region: Methyltransf_26; pfam13659
497965013061	S-adenosylmethionine binding site [chemical binding]; other site
497965013062	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
497965013063	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
497965013064	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013065	binding surface
497965013066	TPR motif; other site
497965013067	RDD family; Region: RDD; pfam06271
497965013068	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965013069	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965013070	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965013071	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965013072	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965013073	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965013074	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965013075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965013076	active site
497965013077	phosphorylation site [posttranslational modification]
497965013078	intermolecular recognition site; other site
497965013079	dimerization interface [polypeptide binding]; other site
497965013080	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
497965013081	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
497965013082	Coenzyme A binding pocket [chemical binding]; other site
497965013083	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497965013084	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
497965013085	putative di-iron ligands [ion binding]; other site
497965013086	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
497965013087	active site
497965013088	dinuclear metal binding site [ion binding]; other site
497965013089	dimerization interface [polypeptide binding]; other site
497965013090	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
497965013091	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
497965013092	active site
497965013093	metal binding site [ion binding]; metal-binding site
497965013094	Uncharacterized conserved protein [Function unknown]; Region: COG2135
497965013095	Uncharacterized conserved protein [Function unknown]; Region: COG5464
497965013096	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
497965013097	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
497965013098	putative active site [active]
497965013099	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
497965013100	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965013101	putative active site [active]
497965013102	CHAT domain; Region: CHAT; cl17868
497965013103	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965013104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965013105	active site
497965013106	phosphorylation site [posttranslational modification]
497965013107	intermolecular recognition site; other site
497965013108	dimerization interface [polypeptide binding]; other site
497965013109	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965013110	DNA binding residues [nucleotide binding]
497965013111	dimerization interface [polypeptide binding]; other site
497965013112	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
497965013113	spermine synthase; Region: PLN02823
497965013114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965013115	S-adenosylmethionine binding site [chemical binding]; other site
497965013116	GUN4-like; Region: GUN4; pfam05419
497965013117	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965013118	GAF domain; Region: GAF; pfam01590
497965013119	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965013120	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
497965013121	dimer interface [polypeptide binding]; other site
497965013122	phosphorylation site [posttranslational modification]
497965013123	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
497965013124	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
497965013125	PAS domain S-box; Region: sensory_box; TIGR00229
497965013126	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965013127	putative active site [active]
497965013128	heme pocket [chemical binding]; other site
497965013129	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965013130	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965013131	putative active site [active]
497965013132	heme pocket [chemical binding]; other site
497965013133	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965013134	dimer interface [polypeptide binding]; other site
497965013135	phosphorylation site [posttranslational modification]
497965013136	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965013137	ATP binding site [chemical binding]; other site
497965013138	Mg2+ binding site [ion binding]; other site
497965013139	G-X-G motif; other site
497965013140	Response regulator receiver domain; Region: Response_reg; pfam00072
497965013141	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965013142	active site
497965013143	phosphorylation site [posttranslational modification]
497965013144	intermolecular recognition site; other site
497965013145	dimerization interface [polypeptide binding]; other site
497965013146	aspartate aminotransferase; Provisional; Region: PRK05957
497965013147	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497965013148	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965013149	homodimer interface [polypeptide binding]; other site
497965013150	catalytic residue [active]
497965013151	PAS fold; Region: PAS; pfam00989
497965013152	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965013153	putative active site [active]
497965013154	heme pocket [chemical binding]; other site
497965013155	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965013156	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965013157	ligand binding site [chemical binding]; other site
497965013158	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
497965013159	putative switch regulator; other site
497965013160	non-specific DNA interactions [nucleotide binding]; other site
497965013161	DNA binding site [nucleotide binding]
497965013162	sequence specific DNA binding site [nucleotide binding]; other site
497965013163	putative cAMP binding site [chemical binding]; other site
497965013164	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
497965013165	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
497965013166	acyl-activating enzyme (AAE) consensus motif; other site
497965013167	putative AMP binding site [chemical binding]; other site
497965013168	putative active site [active]
497965013169	putative CoA binding site [chemical binding]; other site
497965013170	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
497965013171	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
497965013172	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965013173	S-adenosylmethionine binding site [chemical binding]; other site
497965013174	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
497965013175	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965013176	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
497965013177	Coenzyme A binding pocket [chemical binding]; other site
497965013178	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
497965013179	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
497965013180	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
497965013181	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
497965013182	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
497965013183	nucleophile elbow; other site
497965013184	Cupin superfamily protein; Region: Cupin_4; pfam08007
497965013185	Cupin-like domain; Region: Cupin_8; pfam13621
497965013186	ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184
497965013187	ATP-grasp domain; Region: ATP-grasp_4; cl17255
497965013188	ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185
497965013189	ATP-grasp domain; Region: ATP-grasp_4; cl17255
497965013190	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
497965013191	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
497965013192	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
497965013193	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
497965013194	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
497965013195	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
497965013196	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
497965013197	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
497965013198	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
497965013199	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
497965013200	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
497965013201	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965013202	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
497965013203	NAD(P) binding site [chemical binding]; other site
497965013204	active site
497965013205	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
497965013206	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
497965013207	E3 interaction surface; other site
497965013208	lipoyl attachment site [posttranslational modification]; other site
497965013209	e3 binding domain; Region: E3_binding; pfam02817
497965013210	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
497965013211	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965013212	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
497965013213	elongation factor G; Reviewed; Region: PRK12740
497965013214	G1 box; other site
497965013215	putative GEF interaction site [polypeptide binding]; other site
497965013216	GTP/Mg2+ binding site [chemical binding]; other site
497965013217	Switch I region; other site
497965013218	G2 box; other site
497965013219	G3 box; other site
497965013220	Switch II region; other site
497965013221	G4 box; other site
497965013222	G5 box; other site
497965013223	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
497965013224	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
497965013225	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
497965013226	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
497965013227	catalytic residues [active]
497965013228	circadian clock protein KaiC; Reviewed; Region: PRK09302
497965013229	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965013230	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965013231	Walker A motif; other site
497965013232	Walker A motif; other site
497965013233	ATP binding site [chemical binding]; other site
497965013234	Walker B motif; other site
497965013235	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965013236	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965013237	Walker A motif; other site
497965013238	Walker A motif; other site
497965013239	ATP binding site [chemical binding]; other site
497965013240	Walker B motif; other site
497965013241	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
497965013242	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965013243	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965013244	metal binding site [ion binding]; metal-binding site
497965013245	active site
497965013246	I-site; other site
497965013247	DNA primase; Validated; Region: dnaG; PRK05667
497965013248	CHC2 zinc finger; Region: zf-CHC2; pfam01807
497965013249	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
497965013250	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
497965013251	active site
497965013252	metal binding site [ion binding]; metal-binding site
497965013253	interdomain interaction site; other site
497965013254	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
497965013255	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
497965013256	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
497965013257	putative metal binding site; other site
497965013258	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
497965013259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013260	TPR motif; other site
497965013261	binding surface
497965013262	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
497965013263	NACHT domain; Region: NACHT; pfam05729
497965013264	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965013265	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965013266	structural tetrad; other site
497965013267	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965013268	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965013269	structural tetrad; other site
497965013270	WD40 repeats; Region: WD40; smart00320
497965013271	WD40 repeats; Region: WD40; smart00320
497965013272	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
497965013273	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
497965013274	Clp protease ATP binding subunit; Region: clpC; CHL00095
497965013275	Clp amino terminal domain; Region: Clp_N; pfam02861
497965013276	Clp amino terminal domain; Region: Clp_N; pfam02861
497965013277	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965013278	Walker A motif; other site
497965013279	ATP binding site [chemical binding]; other site
497965013280	Walker B motif; other site
497965013281	arginine finger; other site
497965013282	UvrB/uvrC motif; Region: UVR; pfam02151
497965013283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965013284	Walker A motif; other site
497965013285	ATP binding site [chemical binding]; other site
497965013286	Walker B motif; other site
497965013287	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
497965013288	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965013289	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965013290	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
497965013291	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497965013292	Homeodomain-like domain; Region: HTH_23; pfam13384
497965013293	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
497965013294	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965013295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
497965013296	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
497965013297	nitrilase; Region: PLN02798
497965013298	putative active site [active]
497965013299	catalytic triad [active]
497965013300	dimer interface [polypeptide binding]; other site
497965013301	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013302	TPR repeat; Region: TPR_11; pfam13414
497965013303	TPR motif; other site
497965013304	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
497965013305	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
497965013306	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
497965013307	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
497965013308	beta-phosphoglucomutase; Region: bPGM; TIGR01990
497965013309	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965013310	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965013311	non-specific DNA binding site [nucleotide binding]; other site
497965013312	salt bridge; other site
497965013313	sequence-specific DNA binding site [nucleotide binding]; other site
497965013314	GUN4-like; Region: GUN4; pfam05419
497965013315	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
497965013316	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
497965013317	active site
497965013318	homodimer interface [polypeptide binding]; other site
497965013319	catalytic site [active]
497965013320	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
497965013321	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
497965013322	active site
497965013323	catalytic site [active]
497965013324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
497965013325	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
497965013326	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
497965013327	active site
497965013328	catalytic triad [active]
497965013329	oxyanion hole [active]
497965013330	hypothetical protein; Provisional; Region: PRK02509
497965013331	Uncharacterized conserved protein [Function unknown]; Region: COG1615
497965013332	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
497965013333	active site
497965013334	catalytic triad [active]
497965013335	oxyanion hole [active]
497965013336	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965013337	putative active site [active]
497965013338	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
497965013339	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
497965013340	catalytic motif [active]
497965013341	Zn binding site [ion binding]; other site
497965013342	Rhomboid family; Region: Rhomboid; pfam01694
497965013343	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
497965013344	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
497965013345	metal binding site [ion binding]; metal-binding site
497965013346	dimer interface [polypeptide binding]; other site
497965013347	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
497965013348	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497965013349	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
497965013350	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497965013351	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497965013352	Peptidase family M23; Region: Peptidase_M23; pfam01551
497965013353	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
497965013354	Predicted integral membrane protein [Function unknown]; Region: COG5637
497965013355	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
497965013356	putative hydrophobic ligand binding site [chemical binding]; other site
497965013357	Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002
497965013358	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
497965013359	FAD binding domain; Region: FAD_binding_4; pfam01565
497965013360	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
497965013361	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965013362	PAS fold; Region: PAS_3; pfam08447
497965013363	putative active site [active]
497965013364	heme pocket [chemical binding]; other site
497965013365	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965013366	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965013367	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965013368	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965013369	metal binding site [ion binding]; metal-binding site
497965013370	active site
497965013371	I-site; other site
497965013372	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
497965013373	active site
497965013374	phosphorylation site [posttranslational modification]
497965013375	intermolecular recognition site; other site
497965013376	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
497965013377	Predicted membrane protein [Function unknown]; Region: COG4270
497965013378	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
497965013379	AAA domain; Region: AAA_21; pfam13304
497965013380	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
497965013381	Clp amino terminal domain; Region: Clp_N; pfam02861
497965013382	Clp amino terminal domain; Region: Clp_N; pfam02861
497965013383	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965013384	Walker A motif; other site
497965013385	ATP binding site [chemical binding]; other site
497965013386	Walker B motif; other site
497965013387	arginine finger; other site
497965013388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965013389	Walker A motif; other site
497965013390	ATP binding site [chemical binding]; other site
497965013391	Walker B motif; other site
497965013392	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
497965013393	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497965013394	active site
497965013395	S-layer homology domain; Region: SLH; pfam00395
497965013396	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
497965013397	nucleoside/Zn binding site; other site
497965013398	dimer interface [polypeptide binding]; other site
497965013399	catalytic motif [active]
497965013400	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
497965013401	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
497965013402	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
497965013403	Ligand Binding Site [chemical binding]; other site
497965013404	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497965013405	Ligand Binding Site [chemical binding]; other site
497965013406	Phosphate-starvation-inducible E; Region: PsiE; cl01264
497965013407	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965013408	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965013409	active site
497965013410	ATP binding site [chemical binding]; other site
497965013411	substrate binding site [chemical binding]; other site
497965013412	activation loop (A-loop); other site
497965013413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013414	TPR repeat; Region: TPR_11; pfam13414
497965013415	binding surface
497965013416	TPR motif; other site
497965013417	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013418	binding surface
497965013419	TPR motif; other site
497965013420	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
497965013421	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013422	binding surface
497965013423	TPR motif; other site
497965013424	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013425	binding surface
497965013426	TPR motif; other site
497965013427	Tetratricopeptide repeat; Region: TPR_16; pfam13432
497965013428	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
497965013429	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
497965013430	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
497965013431	Zn2+ binding site [ion binding]; other site
497965013432	Mg2+ binding site [ion binding]; other site
497965013433	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
497965013434	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
497965013435	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965013436	Mg2+ binding site [ion binding]; other site
497965013437	G-X-G motif; other site
497965013438	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
497965013439	anchoring element; other site
497965013440	dimer interface [polypeptide binding]; other site
497965013441	ATP binding site [chemical binding]; other site
497965013442	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
497965013443	active site
497965013444	putative metal-binding site [ion binding]; other site
497965013445	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
497965013446	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
497965013447	Phosphate acyltransferases; Region: PlsC; smart00563
497965013448	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
497965013449	putative acyl-acceptor binding pocket; other site
497965013450	proton extrusion protein PcxA; Provisional; Region: PRK02507
497965013451	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
497965013452	active site clefts [active]
497965013453	zinc binding site [ion binding]; other site
497965013454	dimer interface [polypeptide binding]; other site
497965013455	Nitrogen regulatory protein P-II; Region: P-II; cl00412
497965013456	Domain of unknown function (DUF897); Region: DUF897; pfam05982
497965013457	Predicted metalloprotease [General function prediction only]; Region: COG2321
497965013458	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
497965013459	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965013460	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965013461	Probable transposase; Region: OrfB_IS605; pfam01385
497965013462	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965013463	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965013464	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
497965013465	dimerization interface [polypeptide binding]; other site
497965013466	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965013467	dimer interface [polypeptide binding]; other site
497965013468	phosphorylation site [posttranslational modification]
497965013469	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965013470	ATP binding site [chemical binding]; other site
497965013471	Mg2+ binding site [ion binding]; other site
497965013472	G-X-G motif; other site
497965013473	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965013474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965013475	active site
497965013476	phosphorylation site [posttranslational modification]
497965013477	intermolecular recognition site; other site
497965013478	dimerization interface [polypeptide binding]; other site
497965013479	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965013480	DNA binding site [nucleotide binding]
497965013481	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
497965013482	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
497965013483	active site
497965013484	zinc binding site [ion binding]; other site
497965013485	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
497965013486	active site
497965013487	zinc binding site [ion binding]; other site
497965013488	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
497965013489	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965013490	Walker A/P-loop; other site
497965013491	ATP binding site [chemical binding]; other site
497965013492	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965013493	putative active site [active]
497965013494	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
497965013495	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
497965013496	domain interfaces; other site
497965013497	active site
497965013498	2-isopropylmalate synthase; Validated; Region: PRK00915
497965013499	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
497965013500	active site
497965013501	catalytic residues [active]
497965013502	metal binding site [ion binding]; metal-binding site
497965013503	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
497965013504	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
497965013505	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
497965013506	substrate binding site [chemical binding]; other site
497965013507	dimer interface [polypeptide binding]; other site
497965013508	ATP binding site [chemical binding]; other site
497965013509	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
497965013510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
497965013511	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
497965013512	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
497965013513	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
497965013514	NADH(P)-binding; Region: NAD_binding_10; pfam13460
497965013515	NAD(P) binding site [chemical binding]; other site
497965013516	putative active site [active]
497965013517	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
497965013518	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
497965013519	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
497965013520	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
497965013521	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
497965013522	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
497965013523	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
497965013524	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
497965013525	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
497965013526	Phosphotransferase enzyme family; Region: APH; pfam01636
497965013527	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
497965013528	active site
497965013529	ATP binding site [chemical binding]; other site
497965013530	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
497965013531	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
497965013532	purine monophosphate binding site [chemical binding]; other site
497965013533	dimer interface [polypeptide binding]; other site
497965013534	putative catalytic residues [active]
497965013535	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
497965013536	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
497965013537	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
497965013538	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965013539	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
497965013540	HSP70 interaction site [polypeptide binding]; other site
497965013541	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
497965013542	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
497965013543	homodimer interface [polypeptide binding]; other site
497965013544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965013545	catalytic residue [active]
497965013546	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497965013547	Ligand Binding Site [chemical binding]; other site
497965013548	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965013549	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
497965013550	O-Antigen ligase; Region: Wzy_C; pfam04932
497965013551	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013552	TPR motif; other site
497965013553	binding surface
497965013554	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
497965013555	XisI protein; Region: XisI; pfam08869
497965013556	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
497965013557	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
497965013558	DNA binding site [nucleotide binding]
497965013559	catalytic residue [active]
497965013560	H2TH interface [polypeptide binding]; other site
497965013561	putative catalytic residues [active]
497965013562	turnover-facilitating residue; other site
497965013563	intercalation triad [nucleotide binding]; other site
497965013564	8OG recognition residue [nucleotide binding]; other site
497965013565	putative reading head residues; other site
497965013566	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
497965013567	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
497965013568	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
497965013569	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
497965013570	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
497965013571	photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200
497965013572	Homeodomain-like domain; Region: HTH_23; pfam13384
497965013573	Winged helix-turn helix; Region: HTH_29; pfam13551
497965013574	Homeodomain-like domain; Region: HTH_32; pfam13565
497965013575	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
497965013576	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
497965013577	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
497965013578	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
497965013579	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
497965013580	DinB superfamily; Region: DinB_2; pfam12867
497965013581	Cupin domain; Region: Cupin_2; pfam07883
497965013582	Tic20-like protein; Region: Tic20; pfam09685
497965013583	CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cl09837
497965013584	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
497965013585	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
497965013586	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732
497965013587	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439
497965013588	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
497965013589	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
497965013590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965013591	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497965013592	putative substrate translocation pore; other site
497965013593	Family of unknown function (DUF490); Region: DUF490; pfam04357
497965013594	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
497965013595	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
497965013596	NAD(P) binding site [chemical binding]; other site
497965013597	catalytic residues [active]
497965013598	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
497965013599	active site
497965013600	catalytic triad [active]
497965013601	oxyanion hole [active]
497965013602	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
497965013603	calcium/proton exchanger (cax); Region: cax; TIGR00378
497965013604	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
497965013605	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
497965013606	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
497965013607	substrate binding pocket [chemical binding]; other site
497965013608	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497965013609	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
497965013610	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
497965013611	homodimer interface [polypeptide binding]; other site
497965013612	substrate-cofactor binding pocket; other site
497965013613	Aminotransferase class IV; Region: Aminotran_4; pfam01063
497965013614	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965013615	catalytic residue [active]
497965013616	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965013617	putative active site [active]
497965013618	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
497965013619	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
497965013620	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
497965013621	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
497965013622	Predicted permeases [General function prediction only]; Region: COG0795
497965013623	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
497965013624	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
497965013625	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
497965013626	Walker A/P-loop; other site
497965013627	ATP binding site [chemical binding]; other site
497965013628	Q-loop/lid; other site
497965013629	ABC transporter signature motif; other site
497965013630	Walker B; other site
497965013631	D-loop; other site
497965013632	H-loop/switch region; other site
497965013633	OstA-like protein; Region: OstA; pfam03968
497965013634	Domain of unknown function (DUF309); Region: DUF309; pfam03745
497965013635	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
497965013636	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
497965013637	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
497965013638	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497965013639	active site
497965013640	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
497965013641	calcium mediated ligand binding site; other site
497965013642	intermolecular salt bridges; other site
497965013643	adenylosuccinate lyase; Provisional; Region: PRK07380
497965013644	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
497965013645	tetramer interface [polypeptide binding]; other site
497965013646	active site
497965013647	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
497965013648	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
497965013649	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965013650	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
497965013651	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
497965013652	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965013653	ATP binding site [chemical binding]; other site
497965013654	putative Mg++ binding site [ion binding]; other site
497965013655	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965013656	nucleotide binding region [chemical binding]; other site
497965013657	ATP-binding site [chemical binding]; other site
497965013658	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
497965013659	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
497965013660	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
497965013661	Electron transfer DM13; Region: DM13; pfam10517
497965013662	peptide chain release factor 1; Validated; Region: prfA; PRK00591
497965013663	This domain is found in peptide chain release factors; Region: PCRF; smart00937
497965013664	RF-1 domain; Region: RF-1; pfam00472
497965013665	ribosomal protein L31; Validated; Region: rpl31; CHL00136
497965013666	ribosomal protein S9; Region: rps9; CHL00079
497965013667	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
497965013668	23S rRNA interface [nucleotide binding]; other site
497965013669	L3 interface [polypeptide binding]; other site
497965013670	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
497965013671	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
497965013672	dimerization interface 3.5A [polypeptide binding]; other site
497965013673	active site
497965013674	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
497965013675	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
497965013676	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
497965013677	alphaNTD - beta interaction site [polypeptide binding]; other site
497965013678	alphaNTD homodimer interface [polypeptide binding]; other site
497965013679	alphaNTD - beta' interaction site [polypeptide binding]; other site
497965013680	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
497965013681	30S ribosomal protein S11; Validated; Region: PRK05309
497965013682	ribosomal protein S13; Validated; Region: rps13; CHL00137
497965013683	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
497965013684	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
497965013685	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
497965013686	rRNA binding site [nucleotide binding]; other site
497965013687	predicted 30S ribosome binding site; other site
497965013688	adenylate kinase; Provisional; Region: adk; PRK02496
497965013689	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
497965013690	AMP-binding site [chemical binding]; other site
497965013691	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
497965013692	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
497965013693	SecY translocase; Region: SecY; pfam00344
497965013694	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
497965013695	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
497965013696	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
497965013697	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
497965013698	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
497965013699	5S rRNA interface [nucleotide binding]; other site
497965013700	23S rRNA interface [nucleotide binding]; other site
497965013701	L5 interface [polypeptide binding]; other site
497965013702	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
497965013703	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
497965013704	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
497965013705	ribosomal protein S8; Region: rps8; CHL00042
497965013706	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
497965013707	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
497965013708	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
497965013709	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
497965013710	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
497965013711	RNA binding site [nucleotide binding]; other site
497965013712	ribosomal protein L14; Region: rpl14; CHL00057
497965013713	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
497965013714	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
497965013715	23S rRNA interface [nucleotide binding]; other site
497965013716	putative translocon interaction site; other site
497965013717	signal recognition particle (SRP54) interaction site; other site
497965013718	L23 interface [polypeptide binding]; other site
497965013719	trigger factor interaction site; other site
497965013720	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
497965013721	23S rRNA interface [nucleotide binding]; other site
497965013722	5S rRNA interface [nucleotide binding]; other site
497965013723	putative antibiotic binding site [chemical binding]; other site
497965013724	L25 interface [polypeptide binding]; other site
497965013725	L27 interface [polypeptide binding]; other site
497965013726	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
497965013727	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
497965013728	G-X-X-G motif; other site
497965013729	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
497965013730	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
497965013731	putative translocon binding site; other site
497965013732	protein-rRNA interface [nucleotide binding]; other site
497965013733	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
497965013734	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
497965013735	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
497965013736	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
497965013737	ribosomal protein L23; Region: rpl23; CHL00030
497965013738	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
497965013739	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
497965013740	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
497965013741	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
497965013742	trimer interface [polypeptide binding]; other site
497965013743	active site
497965013744	substrate binding site [chemical binding]; other site
497965013745	CoA binding site [chemical binding]; other site
497965013746	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
497965013747	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965013748	putative substrate translocation pore; other site
497965013749	Protein phosphatase 2C; Region: PP2C_2; pfam13672
497965013750	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
497965013751	metal ion-dependent adhesion site (MIDAS); other site
497965013752	Protein phosphatase 2C; Region: PP2C_2; pfam13672
497965013753	active site
497965013754	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
497965013755	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965013756	active site
497965013757	ATP binding site [chemical binding]; other site
497965013758	substrate binding site [chemical binding]; other site
497965013759	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
497965013760	substrate binding site [chemical binding]; other site
497965013761	activation loop (A-loop); other site
497965013762	activation loop (A-loop); other site
497965013763	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
497965013764	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
497965013765	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965013766	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
497965013767	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
497965013768	Coenzyme A binding pocket [chemical binding]; other site
497965013769	Phosphate acyltransferases; Region: PlsC; smart00563
497965013770	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
497965013771	putative acyl-acceptor binding pocket; other site
497965013772	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
497965013773	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
497965013774	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
497965013775	active site
497965013776	catalytic site [active]
497965013777	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
497965013778	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
497965013779	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497965013780	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
497965013781	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
497965013782	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
497965013783	UbiA prenyltransferase family; Region: UbiA; pfam01040
497965013784	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
497965013785	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
497965013786	C-terminal domain interface [polypeptide binding]; other site
497965013787	GSH binding site (G-site) [chemical binding]; other site
497965013788	dimer interface [polypeptide binding]; other site
497965013789	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
497965013790	N-terminal domain interface [polypeptide binding]; other site
497965013791	putative dimer interface [polypeptide binding]; other site
497965013792	active site
497965013793	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
497965013794	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497965013795	putative C-terminal domain interface [polypeptide binding]; other site
497965013796	putative GSH binding site (G-site) [chemical binding]; other site
497965013797	putative dimer interface [polypeptide binding]; other site
497965013798	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
497965013799	putative N-terminal domain interface [polypeptide binding]; other site
497965013800	putative dimer interface [polypeptide binding]; other site
497965013801	putative substrate binding pocket (H-site) [chemical binding]; other site
497965013802	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
497965013803	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
497965013804	FMN binding site [chemical binding]; other site
497965013805	active site
497965013806	substrate binding site [chemical binding]; other site
497965013807	catalytic residue [active]
497965013808	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
497965013809	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
497965013810	catalytic residues [active]
497965013811	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497965013812	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497965013813	Haemolytic domain; Region: Haemolytic; cl00506
497965013814	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
497965013815	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
497965013816	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
497965013817	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
497965013818	thiS-thiF/thiG interaction site; other site
497965013819	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
497965013820	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
497965013821	thiamine phosphate binding site [chemical binding]; other site
497965013822	active site
497965013823	pyrophosphate binding site [ion binding]; other site
497965013824	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
497965013825	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
497965013826	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
497965013827	active site
497965013828	Zn binding site [ion binding]; other site
497965013829	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
497965013830	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
497965013831	Multicopper oxidase; Region: Cu-oxidase; pfam00394
497965013832	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
497965013833	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
497965013834	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
497965013835	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
497965013836	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965013837	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
497965013838	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497965013839	putative di-iron ligands [ion binding]; other site
497965013840	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
497965013841	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
497965013842	active site
497965013843	TDP-binding site; other site
497965013844	acceptor substrate-binding pocket; other site
497965013845	homodimer interface [polypeptide binding]; other site
497965013846	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965013847	Coenzyme A binding pocket [chemical binding]; other site
497965013848	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
497965013849	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965013850	NAD(P) binding site [chemical binding]; other site
497965013851	active site
497965013852	calcium/proton exchanger (cax); Region: cax; TIGR00378
497965013853	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
497965013854	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
497965013855	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
497965013856	active site
497965013857	hydrophilic channel; other site
497965013858	dimerization interface [polypeptide binding]; other site
497965013859	catalytic residues [active]
497965013860	active site lid [active]
497965013861	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
497965013862	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
497965013863	Tetramer interface [polypeptide binding]; other site
497965013864	active site
497965013865	FMN-binding site [chemical binding]; other site
497965013866	XisH protein; Region: XisH; pfam08814
497965013867	XisI protein; Region: XisI; pfam08869
497965013868	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965013869	putative active site [active]
497965013870	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965013871	Ca2+ binding site [ion binding]; other site
497965013872	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965013873	Ca2+ binding site [ion binding]; other site
497965013874	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965013875	Ca2+ binding site [ion binding]; other site
497965013876	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965013877	Ca2+ binding site [ion binding]; other site
497965013878	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965013879	S-adenosylmethionine binding site [chemical binding]; other site
497965013880	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
497965013881	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
497965013882	domain interfaces; other site
497965013883	active site
497965013884	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965013885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965013886	active site
497965013887	phosphorylation site [posttranslational modification]
497965013888	intermolecular recognition site; other site
497965013889	dimerization interface [polypeptide binding]; other site
497965013890	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965013891	DNA binding site [nucleotide binding]
497965013892	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497965013893	putative binding surface; other site
497965013894	active site
497965013895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965013896	active site
497965013897	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
497965013898	phosphorylation site [posttranslational modification]
497965013899	intermolecular recognition site; other site
497965013900	dimerization interface [polypeptide binding]; other site
497965013901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965013902	active site
497965013903	phosphorylation site [posttranslational modification]
497965013904	intermolecular recognition site; other site
497965013905	dimerization interface [polypeptide binding]; other site
497965013906	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965013907	metal binding site [ion binding]; metal-binding site
497965013908	active site
497965013909	I-site; other site
497965013910	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
497965013911	GAF domain; Region: GAF; pfam01590
497965013912	Phytochrome region; Region: PHY; pfam00360
497965013913	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965013914	dimer interface [polypeptide binding]; other site
497965013915	phosphorylation site [posttranslational modification]
497965013916	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965013917	ATP binding site [chemical binding]; other site
497965013918	Mg2+ binding site [ion binding]; other site
497965013919	G-X-G motif; other site
497965013920	Response regulator receiver domain; Region: Response_reg; pfam00072
497965013921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965013922	active site
497965013923	phosphorylation site [posttranslational modification]
497965013924	intermolecular recognition site; other site
497965013925	dimerization interface [polypeptide binding]; other site
497965013926	GTP-binding protein YchF; Reviewed; Region: PRK09601
497965013927	YchF GTPase; Region: YchF; cd01900
497965013928	G1 box; other site
497965013929	GTP/Mg2+ binding site [chemical binding]; other site
497965013930	Switch I region; other site
497965013931	G2 box; other site
497965013932	Switch II region; other site
497965013933	G3 box; other site
497965013934	G4 box; other site
497965013935	G5 box; other site
497965013936	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
497965013937	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
497965013938	NAD(P) binding pocket [chemical binding]; other site
497965013939	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
497965013940	Ycf35; Provisional; Region: ycf35; CHL00193
497965013941	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
497965013942	yiaA/B two helix domain; Region: YiaAB; cl01759
497965013943	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
497965013944	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
497965013945	acyl-activating enzyme (AAE) consensus motif; other site
497965013946	active site
497965013947	CoA binding site [chemical binding]; other site
497965013948	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
497965013949	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
497965013950	active site
497965013951	catalytic residues [active]
497965013952	CTP synthetase; Validated; Region: pyrG; PRK05380
497965013953	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
497965013954	Catalytic site [active]
497965013955	active site
497965013956	UTP binding site [chemical binding]; other site
497965013957	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
497965013958	active site
497965013959	putative oxyanion hole; other site
497965013960	catalytic triad [active]
497965013961	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
497965013962	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
497965013963	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
497965013964	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
497965013965	catalytic triad [active]
497965013966	AAA ATPase domain; Region: AAA_16; pfam13191
497965013967	AAA domain; Region: AAA_22; pfam13401
497965013968	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013969	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013970	binding surface
497965013971	TPR motif; other site
497965013972	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013973	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013974	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013975	Tetratricopeptide repeat; Region: TPR_10; pfam13374
497965013976	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013977	binding surface
497965013978	TPR motif; other site
497965013979	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013980	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013981	binding surface
497965013982	TPR motif; other site
497965013983	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013984	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013985	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965013986	binding surface
497965013987	TPR motif; other site
497965013988	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965013989	PIN domain; Region: PIN; pfam01850
497965013990	4-alpha-glucanotransferase; Provisional; Region: PRK14508
497965013991	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
497965013992	trehalose synthase; Region: treS_nterm; TIGR02456
497965013993	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
497965013994	active site
497965013995	catalytic site [active]
497965013996	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
497965013997	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
497965013998	Heat induced stress protein YflT; Region: YflT; pfam11181
497965013999	CVNH domain; Region: CVNH; pfam08881
497965014000	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
497965014001	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965014002	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965014003	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774
497965014004	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965014005	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
497965014006	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cd09852
497965014007	putative active site [active]
497965014008	NB-ARC domain; Region: NB-ARC; pfam00931
497965014009	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
497965014010	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
497965014011	active site
497965014012	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
497965014013	high affinity sulphate transporter 1; Region: sulP; TIGR00815
497965014014	Sulfate transporter family; Region: Sulfate_transp; pfam00916
497965014015	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
497965014016	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
497965014017	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
497965014018	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965014019	FeS/SAM binding site; other site
497965014020	TRAM domain; Region: TRAM; pfam01938
497965014021	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497965014022	active site
497965014023	DNA binding site [nucleotide binding]
497965014024	Int/Topo IB signature motif; other site
497965014025	Photosystem I protein M (PsaM); Region: PsaM; pfam07465
497965014026	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965014027	Probable transposase; Region: OrfB_IS605; pfam01385
497965014028	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965014029	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965014030	Bacitracin resistance protein BacA; Region: BacA; cl00858
497965014031	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
497965014032	putative switch regulator; other site
497965014033	non-specific DNA interactions [nucleotide binding]; other site
497965014034	DNA binding site [nucleotide binding]
497965014035	sequence specific DNA binding site [nucleotide binding]; other site
497965014036	putative cAMP binding site [chemical binding]; other site
497965014037	DALR anticodon binding domain; Region: DALR_1; smart00836
497965014038	anticodon binding site; other site
497965014039	tRNA binding surface [nucleotide binding]; other site
497965014040	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
497965014041	active site
497965014042	catalytic site [active]
497965014043	substrate binding site [chemical binding]; other site
497965014044	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
497965014045	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
497965014046	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
497965014047	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
497965014048	Walker A/P-loop; other site
497965014049	ATP binding site [chemical binding]; other site
497965014050	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
497965014051	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
497965014052	ABC transporter signature motif; other site
497965014053	Walker B; other site
497965014054	D-loop; other site
497965014055	H-loop/switch region; other site
497965014056	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965014057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965014058	active site
497965014059	phosphorylation site [posttranslational modification]
497965014060	intermolecular recognition site; other site
497965014061	dimerization interface [polypeptide binding]; other site
497965014062	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965014063	dimer interface [polypeptide binding]; other site
497965014064	phosphorylation site [posttranslational modification]
497965014065	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
497965014066	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965014067	ATP binding site [chemical binding]; other site
497965014068	Mg2+ binding site [ion binding]; other site
497965014069	G-X-G motif; other site
497965014070	FOG: CBS domain [General function prediction only]; Region: COG0517
497965014071	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
497965014072	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
497965014073	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
497965014074	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965014075	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965014076	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
497965014077	Histidine kinase; Region: HisKA_2; pfam07568
497965014078	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965014079	ATP binding site [chemical binding]; other site
497965014080	Mg2+ binding site [ion binding]; other site
497965014081	G-X-G motif; other site
497965014082	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
497965014083	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
497965014084	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
497965014085	TM-ABC transporter signature motif; other site
497965014086	TPR repeat; Region: TPR_11; pfam13414
497965014087	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
497965014088	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
497965014089	putative ligand binding site [chemical binding]; other site
497965014090	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965014091	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965014092	active site
497965014093	ATP binding site [chemical binding]; other site
497965014094	substrate binding site [chemical binding]; other site
497965014095	activation loop (A-loop); other site
497965014096	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
497965014097	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
497965014098	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497965014099	lipoyl synthase; Provisional; Region: PRK12928
497965014100	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497965014101	FeS/SAM binding site; other site
497965014102	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
497965014103	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
497965014104	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
497965014105	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
497965014106	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
497965014107	metal binding site 2 [ion binding]; metal-binding site
497965014108	putative DNA binding helix; other site
497965014109	metal binding site 1 [ion binding]; metal-binding site
497965014110	dimer interface [polypeptide binding]; other site
497965014111	structural Zn2+ binding site [ion binding]; other site
497965014112	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
497965014113	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
497965014114	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
497965014115	putative active site [active]
497965014116	catalytic triad [active]
497965014117	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
497965014118	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
497965014119	Qi binding site; other site
497965014120	intrachain domain interface; other site
497965014121	interchain domain interface [polypeptide binding]; other site
497965014122	heme bH binding site [chemical binding]; other site
497965014123	heme bL binding site [chemical binding]; other site
497965014124	Qo binding site; other site
497965014125	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
497965014126	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
497965014127	interchain domain interface [polypeptide binding]; other site
497965014128	intrachain domain interface; other site
497965014129	Qi binding site; other site
497965014130	Qo binding site; other site
497965014131	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965014132	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965014133	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965014134	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965014135	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
497965014136	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
497965014137	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497965014138	catalytic residue [active]
497965014139	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
497965014140	Uncharacterized conserved protein [Function unknown]; Region: COG1656
497965014141	Protein of unknown function DUF82; Region: DUF82; pfam01927
497965014142	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965014143	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
497965014144	Coenzyme A binding pocket [chemical binding]; other site
497965014145	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
497965014146	MoaE interaction surface [polypeptide binding]; other site
497965014147	MoeB interaction surface [polypeptide binding]; other site
497965014148	thiocarboxylated glycine; other site
497965014149	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965014150	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965014151	active site
497965014152	ATP binding site [chemical binding]; other site
497965014153	substrate binding site [chemical binding]; other site
497965014154	activation loop (A-loop); other site
497965014155	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965014156	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965014157	structural tetrad; other site
497965014158	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965014159	AAA domain; Region: AAA_21; pfam13304
497965014160	Walker A/P-loop; other site
497965014161	ATP binding site [chemical binding]; other site
497965014162	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
497965014163	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
497965014164	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
497965014165	ThiS interaction site; other site
497965014166	putative active site [active]
497965014167	tetramer interface [polypeptide binding]; other site
497965014168	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
497965014169	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
497965014170	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
497965014171	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
497965014172	active site
497965014173	substrate binding site [chemical binding]; other site
497965014174	FMN binding site [chemical binding]; other site
497965014175	putative catalytic residues [active]
497965014176	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
497965014177	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
497965014178	active site
497965014179	ATP binding site [chemical binding]; other site
497965014180	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
497965014181	active site
497965014182	substrate binding site [chemical binding]; other site
497965014183	CoA binding site [chemical binding]; other site
497965014184	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
497965014185	Glucose inhibited division protein A; Region: GIDA; pfam01134
497965014186	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
497965014187	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
497965014188	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
497965014189	Yqey-like protein; Region: YqeY; pfam09424
497965014190	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
497965014191	dimer interface [polypeptide binding]; other site
497965014192	[2Fe-2S] cluster binding site [ion binding]; other site
497965014193	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
497965014194	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965014195	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965014196	active site
497965014197	ATP binding site [chemical binding]; other site
497965014198	substrate binding site [chemical binding]; other site
497965014199	activation loop (A-loop); other site
497965014200	GUN4-like; Region: GUN4; pfam05419
497965014201	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
497965014202	ATP-sulfurylase; Region: ATPS; cd00517
497965014203	active site
497965014204	HXXH motif; other site
497965014205	flexible loop; other site
497965014206	Caspase domain; Region: Peptidase_C14; pfam00656
497965014207	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
497965014208	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
497965014209	hydrophobic ligand binding site; other site
497965014210	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
497965014211	Thf1-like protein; Reviewed; Region: PRK13266
497965014212	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
497965014213	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
497965014214	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
497965014215	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
497965014216	active site
497965014217	homodimer interface [polypeptide binding]; other site
497965014218	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965014219	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
497965014220	propionate/acetate kinase; Provisional; Region: PRK12379
497965014221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
497965014222	conserved hypothetical protein; Region: TIGR03492
497965014223	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
497965014224	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497965014225	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
497965014226	Walker A/P-loop; other site
497965014227	ATP binding site [chemical binding]; other site
497965014228	Q-loop/lid; other site
497965014229	ABC transporter signature motif; other site
497965014230	Walker B; other site
497965014231	D-loop; other site
497965014232	H-loop/switch region; other site
497965014233	hypothetical protein; Provisional; Region: PRK06208
497965014234	intersubunit interface [polypeptide binding]; other site
497965014235	active site
497965014236	Zn2+ binding site [ion binding]; other site
497965014237	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
497965014238	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
497965014239	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
497965014240	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497965014241	Walker A/P-loop; other site
497965014242	ATP binding site [chemical binding]; other site
497965014243	Q-loop/lid; other site
497965014244	ABC transporter signature motif; other site
497965014245	Walker B; other site
497965014246	D-loop; other site
497965014247	H-loop/switch region; other site
497965014248	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497965014249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965014250	dimer interface [polypeptide binding]; other site
497965014251	conserved gate region; other site
497965014252	putative PBP binding loops; other site
497965014253	ABC-ATPase subunit interface; other site
497965014254	Isochorismatase family; Region: Isochorismatase; pfam00857
497965014255	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
497965014256	catalytic triad [active]
497965014257	conserved cis-peptide bond; other site
497965014258	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965014259	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014260	putative active site [active]
497965014261	heme pocket [chemical binding]; other site
497965014262	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014263	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965014264	putative active site [active]
497965014265	heme pocket [chemical binding]; other site
497965014266	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014267	putative active site [active]
497965014268	heme pocket [chemical binding]; other site
497965014269	PAS domain S-box; Region: sensory_box; TIGR00229
497965014270	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014271	putative active site [active]
497965014272	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014273	PAS domain; Region: PAS_9; pfam13426
497965014274	putative active site [active]
497965014275	heme pocket [chemical binding]; other site
497965014276	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965014277	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965014278	metal binding site [ion binding]; metal-binding site
497965014279	active site
497965014280	I-site; other site
497965014281	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965014282	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
497965014283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965014284	S-adenosylmethionine binding site [chemical binding]; other site
497965014285	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965014286	NAD(P) binding site [chemical binding]; other site
497965014287	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
497965014288	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
497965014289	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965014290	active site
497965014291	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
497965014292	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
497965014293	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
497965014294	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
497965014295	active site
497965014296	dimer interface [polypeptide binding]; other site
497965014297	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497965014298	active site
497965014299	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
497965014300	ATP adenylyltransferase; Region: ATP_transf; pfam09830
497965014301	Cupin domain; Region: Cupin_2; pfam07883
497965014302	Protein of unknown function (DUF342); Region: DUF342; pfam03961
497965014303	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
497965014304	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
497965014305	Mg2+ binding site [ion binding]; other site
497965014306	G-X-G motif; other site
497965014307	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
497965014308	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
497965014309	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965014310	S-adenosylmethionine binding site [chemical binding]; other site
497965014311	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014312	putative active site [active]
497965014313	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965014314	heme pocket [chemical binding]; other site
497965014315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014316	putative active site [active]
497965014317	heme pocket [chemical binding]; other site
497965014318	PAS domain S-box; Region: sensory_box; TIGR00229
497965014319	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014320	putative active site [active]
497965014321	heme pocket [chemical binding]; other site
497965014322	PAS domain S-box; Region: sensory_box; TIGR00229
497965014323	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014324	putative active site [active]
497965014325	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014326	PAS fold; Region: PAS_3; pfam08447
497965014327	putative active site [active]
497965014328	heme pocket [chemical binding]; other site
497965014329	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965014330	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965014331	metal binding site [ion binding]; metal-binding site
497965014332	active site
497965014333	I-site; other site
497965014334	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965014335	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
497965014336	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965014337	Walker A/P-loop; other site
497965014338	ATP binding site [chemical binding]; other site
497965014339	Q-loop/lid; other site
497965014340	ABC transporter signature motif; other site
497965014341	Walker B; other site
497965014342	D-loop; other site
497965014343	H-loop/switch region; other site
497965014344	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
497965014345	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
497965014346	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
497965014347	metal ion-dependent adhesion site (MIDAS); other site
497965014348	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
497965014349	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
497965014350	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
497965014351	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
497965014352	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965014353	Walker A motif; other site
497965014354	ATP binding site [chemical binding]; other site
497965014355	Walker B motif; other site
497965014356	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
497965014357	RxxxH motif; other site
497965014358	Protein of unknown function (DUF433); Region: DUF433; cl01030
497965014359	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965014360	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
497965014361	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
497965014362	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965014363	ATP binding site [chemical binding]; other site
497965014364	putative Mg++ binding site [ion binding]; other site
497965014365	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965014366	HsdM N-terminal domain; Region: HsdM_N; pfam12161
497965014367	Methyltransferase domain; Region: Methyltransf_26; pfam13659
497965014368	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
497965014369	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
497965014370	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
497965014371	ligand binding site [chemical binding]; other site
497965014372	active site
497965014373	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
497965014374	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
497965014375	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
497965014376	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497965014377	catalytic core [active]
497965014378	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497965014379	catalytic core [active]
497965014380	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965014381	AAA domain; Region: AAA_21; pfam13304
497965014382	Walker A/P-loop; other site
497965014383	ATP binding site [chemical binding]; other site
497965014384	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965014385	ABC transporter signature motif; other site
497965014386	Walker B; other site
497965014387	D-loop; other site
497965014388	H-loop/switch region; other site
497965014389	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965014390	putative active site [active]
497965014391	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
497965014392	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
497965014393	HIGH motif; other site
497965014394	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
497965014395	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
497965014396	active site
497965014397	KMSKS motif; other site
497965014398	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
497965014399	tRNA binding surface [nucleotide binding]; other site
497965014400	Protein of unknown function (DUF497); Region: DUF497; pfam04365
497965014401	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
497965014402	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
497965014403	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
497965014404	vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461
497965014405	metal ion-dependent adhesion site (MIDAS); other site
497965014406	Hemerythrin-like domain; Region: Hr-like; cd12108
497965014407	Fe binding site [ion binding]; other site
497965014408	AAA ATPase domain; Region: AAA_16; pfam13191
497965014409	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
497965014410	Walker A motif; other site
497965014411	ATP binding site [chemical binding]; other site
497965014412	Walker B motif; other site
497965014413	arginine finger; other site
497965014414	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965014415	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965014416	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965014417	GAF domain; Region: GAF; pfam01590
497965014418	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965014419	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965014420	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965014421	GAF domain; Region: GAF; pfam01590
497965014422	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965014423	dimer interface [polypeptide binding]; other site
497965014424	phosphorylation site [posttranslational modification]
497965014425	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965014426	ATP binding site [chemical binding]; other site
497965014427	Mg2+ binding site [ion binding]; other site
497965014428	G-X-G motif; other site
497965014429	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965014430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965014431	active site
497965014432	phosphorylation site [posttranslational modification]
497965014433	intermolecular recognition site; other site
497965014434	dimerization interface [polypeptide binding]; other site
497965014435	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
497965014436	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
497965014437	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
497965014438	Domain of unknown function (DUF389); Region: DUF389; pfam04087
497965014439	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
497965014440	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
497965014441	NAD binding site [chemical binding]; other site
497965014442	putative substrate binding site 2 [chemical binding]; other site
497965014443	putative substrate binding site 1 [chemical binding]; other site
497965014444	active site
497965014445	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
497965014446	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
497965014447	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
497965014448	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
497965014449	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
497965014450	Walker A/P-loop; other site
497965014451	ATP binding site [chemical binding]; other site
497965014452	Q-loop/lid; other site
497965014453	ABC transporter signature motif; other site
497965014454	Walker B; other site
497965014455	D-loop; other site
497965014456	H-loop/switch region; other site
497965014457	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
497965014458	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497965014459	substrate binding pocket [chemical binding]; other site
497965014460	membrane-bound complex binding site; other site
497965014461	hinge residues; other site
497965014462	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
497965014463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965014464	dimer interface [polypeptide binding]; other site
497965014465	conserved gate region; other site
497965014466	putative PBP binding loops; other site
497965014467	ABC-ATPase subunit interface; other site
497965014468	acetolactate synthase; Reviewed; Region: PRK08322
497965014469	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
497965014470	PYR/PP interface [polypeptide binding]; other site
497965014471	dimer interface [polypeptide binding]; other site
497965014472	TPP binding site [chemical binding]; other site
497965014473	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
497965014474	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
497965014475	TPP-binding site [chemical binding]; other site
497965014476	dimer interface [polypeptide binding]; other site
497965014477	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
497965014478	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014479	PAS fold; Region: PAS_3; pfam08447
497965014480	putative active site [active]
497965014481	heme pocket [chemical binding]; other site
497965014482	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965014483	dimer interface [polypeptide binding]; other site
497965014484	phosphorylation site [posttranslational modification]
497965014485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965014486	ATP binding site [chemical binding]; other site
497965014487	Mg2+ binding site [ion binding]; other site
497965014488	G-X-G motif; other site
497965014489	Response regulator receiver domain; Region: Response_reg; pfam00072
497965014490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965014491	active site
497965014492	phosphorylation site [posttranslational modification]
497965014493	intermolecular recognition site; other site
497965014494	dimerization interface [polypeptide binding]; other site
497965014495	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
497965014496	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
497965014497	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
497965014498	shikimate binding site; other site
497965014499	NAD(P) binding site [chemical binding]; other site
497965014500	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
497965014501	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
497965014502	putative active site [active]
497965014503	catalytic site [active]
497965014504	putative metal binding site [ion binding]; other site
497965014505	YGGT family; Region: YGGT; pfam02325
497965014506	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
497965014507	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965014508	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
497965014509	Low molecular weight phosphatase family; Region: LMWPc; cd00115
497965014510	active site
497965014511	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
497965014512	arsenical-resistance protein; Region: acr3; TIGR00832
497965014513	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497965014514	dimerization interface [polypeptide binding]; other site
497965014515	putative DNA binding site [nucleotide binding]; other site
497965014516	putative Zn2+ binding site [ion binding]; other site
497965014517	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
497965014518	Cadmium resistance transporter; Region: Cad; pfam03596
497965014519	cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779
497965014520	Domain of unknown function (DUF202); Region: DUF202; pfam02656
497965014521	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
497965014522	UbiA prenyltransferase family; Region: UbiA; pfam01040
497965014523	Circadian oscillating protein COP23; Region: COP23; pfam14218
497965014524	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965014525	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
497965014526	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
497965014527	Acyl-CoA oxidase; Region: ACOX; pfam01756
497965014528	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
497965014529	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965014530	S-adenosylmethionine binding site [chemical binding]; other site
497965014531	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
497965014532	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497965014533	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
497965014534	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
497965014535	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
497965014536	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
497965014537	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
497965014538	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
497965014539	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
497965014540	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
497965014541	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
497965014542	DNA binding site [nucleotide binding]
497965014543	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
497965014544	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
497965014545	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
497965014546	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
497965014547	RPB1 interaction site [polypeptide binding]; other site
497965014548	RPB10 interaction site [polypeptide binding]; other site
497965014549	RPB11 interaction site [polypeptide binding]; other site
497965014550	RPB3 interaction site [polypeptide binding]; other site
497965014551	RPB12 interaction site [polypeptide binding]; other site
497965014552	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
497965014553	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
497965014554	active site
497965014555	ribosomal protein S20; Region: rps20; CHL00102
497965014556	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
497965014557	histidinol dehydrogenase; Region: hisD; TIGR00069
497965014558	NAD binding site [chemical binding]; other site
497965014559	dimerization interface [polypeptide binding]; other site
497965014560	product binding site; other site
497965014561	substrate binding site [chemical binding]; other site
497965014562	zinc binding site [ion binding]; other site
497965014563	catalytic residues [active]
497965014564	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
497965014565	metal ion-dependent adhesion site (MIDAS); other site
497965014566	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
497965014567	active site
497965014568	TPR repeat; Region: TPR_11; pfam13414
497965014569	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965014570	binding surface
497965014571	TPR motif; other site
497965014572	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965014573	binding surface
497965014574	TPR motif; other site
497965014575	Tetratricopeptide repeat; Region: TPR_16; pfam13432
497965014576	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965014577	active site
497965014578	ATP binding site [chemical binding]; other site
497965014579	substrate binding site [chemical binding]; other site
497965014580	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
497965014581	substrate binding site [chemical binding]; other site
497965014582	activation loop (A-loop); other site
497965014583	activation loop (A-loop); other site
497965014584	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
497965014585	Ycf46; Provisional; Region: ycf46; CHL00195
497965014586	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965014587	Walker A motif; other site
497965014588	ATP binding site [chemical binding]; other site
497965014589	Walker B motif; other site
497965014590	arginine finger; other site
497965014591	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
497965014592	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
497965014593	dimer interface [polypeptide binding]; other site
497965014594	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965014595	catalytic residue [active]
497965014596	Predicted permeases [General function prediction only]; Region: COG0795
497965014597	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
497965014598	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
497965014599	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
497965014600	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
497965014601	putative ligand binding site [chemical binding]; other site
497965014602	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
497965014603	NlpC/P60 family; Region: NLPC_P60; pfam00877
497965014604	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
497965014605	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965014606	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497965014607	putative substrate translocation pore; other site
497965014608	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
497965014609	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965014610	motif II; other site
497965014611	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
497965014612	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
497965014613	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
497965014614	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
497965014615	MarC family integral membrane protein; Region: MarC; cl00919
497965014616	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
497965014617	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
497965014618	Walker A/P-loop; other site
497965014619	ATP binding site [chemical binding]; other site
497965014620	Q-loop/lid; other site
497965014621	ABC transporter signature motif; other site
497965014622	Walker B; other site
497965014623	D-loop; other site
497965014624	H-loop/switch region; other site
497965014625	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
497965014626	putative carbohydrate binding site [chemical binding]; other site
497965014627	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
497965014628	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497965014629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965014630	S-adenosylmethionine binding site [chemical binding]; other site
497965014631	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
497965014632	Methyltransferase domain; Region: Methyltransf_11; pfam08241
497965014633	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965014634	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
497965014635	NAD(P) binding site [chemical binding]; other site
497965014636	active site
497965014637	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
497965014638	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
497965014639	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
497965014640	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965014641	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965014642	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
497965014643	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
497965014644	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965014645	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965014646	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965014647	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965014648	putative active site [active]
497965014649	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965014650	putative active site [active]
497965014651	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
497965014652	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
497965014653	Probable Catalytic site; other site
497965014654	metal-binding site
497965014655	DGQHR domain; Region: DGQHR; TIGR03187
497965014656	DNA-sulfur modification-associated; Region: DndB; cl17621
497965014657	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
497965014658	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
497965014659	Zn2+ binding site [ion binding]; other site
497965014660	Mg2+ binding site [ion binding]; other site
497965014661	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
497965014662	synthetase active site [active]
497965014663	NTP binding site [chemical binding]; other site
497965014664	metal binding site [ion binding]; metal-binding site
497965014665	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
497965014666	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
497965014667	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
497965014668	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
497965014669	P-loop; other site
497965014670	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
497965014671	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
497965014672	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
497965014673	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497965014674	putative di-iron ligands [ion binding]; other site
497965014675	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
497965014676	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
497965014677	quinone interaction residues [chemical binding]; other site
497965014678	active site
497965014679	catalytic residues [active]
497965014680	FMN binding site [chemical binding]; other site
497965014681	substrate binding site [chemical binding]; other site
497965014682	ribosome maturation protein RimP; Reviewed; Region: PRK00092
497965014683	Sm and related proteins; Region: Sm_like; cl00259
497965014684	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
497965014685	putative oligomer interface [polypeptide binding]; other site
497965014686	putative RNA binding site [nucleotide binding]; other site
497965014687	NusA N-terminal domain; Region: NusA_N; pfam08529
497965014688	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
497965014689	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
497965014690	RNA binding site [nucleotide binding]; other site
497965014691	homodimer interface [polypeptide binding]; other site
497965014692	NusA-like KH domain; Region: KH_5; pfam13184
497965014693	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
497965014694	G-X-X-G motif; other site
497965014695	Protein of unknown function (DUF448); Region: DUF448; pfam04296
497965014696	putative RNA binding cleft [nucleotide binding]; other site
497965014697	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
497965014698	translation initiation factor IF-2; Region: IF-2; TIGR00487
497965014699	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
497965014700	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
497965014701	G1 box; other site
497965014702	putative GEF interaction site [polypeptide binding]; other site
497965014703	GTP/Mg2+ binding site [chemical binding]; other site
497965014704	Switch I region; other site
497965014705	G2 box; other site
497965014706	G3 box; other site
497965014707	Switch II region; other site
497965014708	G4 box; other site
497965014709	G5 box; other site
497965014710	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
497965014711	Translation-initiation factor 2; Region: IF-2; pfam11987
497965014712	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
497965014713	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
497965014714	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
497965014715	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
497965014716	active site
497965014717	catalytic triad [active]
497965014718	oxyanion hole [active]
497965014719	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
497965014720	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
497965014721	G1 box; other site
497965014722	putative GEF interaction site [polypeptide binding]; other site
497965014723	GTP/Mg2+ binding site [chemical binding]; other site
497965014724	Switch I region; other site
497965014725	G2 box; other site
497965014726	G3 box; other site
497965014727	Switch II region; other site
497965014728	G4 box; other site
497965014729	G5 box; other site
497965014730	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
497965014731	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
497965014732	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965014733	Ferredoxin [Energy production and conversion]; Region: COG1146
497965014734	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
497965014735	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
497965014736	Walker A/P-loop; other site
497965014737	ATP binding site [chemical binding]; other site
497965014738	Q-loop/lid; other site
497965014739	ABC transporter signature motif; other site
497965014740	Walker B; other site
497965014741	D-loop; other site
497965014742	H-loop/switch region; other site
497965014743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
497965014744	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
497965014745	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497965014746	Methyltransferase domain; Region: Methyltransf_12; pfam08242
497965014747	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
497965014748	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
497965014749	diiron binding motif [ion binding]; other site
497965014750	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
497965014751	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
497965014752	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
497965014753	active site
497965014754	Riboflavin kinase; Region: Flavokinase; pfam01687
497965014755	MoxR-like ATPases [General function prediction only]; Region: COG0714
497965014756	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965014757	Walker A motif; other site
497965014758	ATP binding site [chemical binding]; other site
497965014759	Walker B motif; other site
497965014760	arginine finger; other site
497965014761	Dihaem cytochrome c; Region: DHC; pfam09626
497965014762	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
497965014763	Proline dehydrogenase; Region: Pro_dh; pfam01619
497965014764	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
497965014765	delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
497965014766	Glutamate binding site [chemical binding]; other site
497965014767	homodimer interface [polypeptide binding]; other site
497965014768	NAD binding site [chemical binding]; other site
497965014769	catalytic residues [active]
497965014770	Calx-beta domain; Region: Calx-beta; pfam03160
497965014771	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
497965014772	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
497965014773	GIY-YIG motif/motif A; other site
497965014774	active site
497965014775	catalytic site [active]
497965014776	putative DNA binding site [nucleotide binding]; other site
497965014777	metal binding site [ion binding]; metal-binding site
497965014778	UvrB/uvrC motif; Region: UVR; pfam02151
497965014779	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
497965014780	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965014781	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
497965014782	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965014783	Walker A motif; other site
497965014784	ATP binding site [chemical binding]; other site
497965014785	Walker B motif; other site
497965014786	arginine finger; other site
497965014787	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
497965014788	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
497965014789	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
497965014790	substrate binding site [chemical binding]; other site
497965014791	glutamase interaction surface [polypeptide binding]; other site
497965014792	Cupin domain; Region: Cupin_2; pfam07883
497965014793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
497965014794	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
497965014795	Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899
497965014796	hypothetical protein; Validated; Region: PRK00110
497965014797	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
497965014798	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
497965014799	active site
497965014800	substrate-binding site [chemical binding]; other site
497965014801	metal-binding site [ion binding]
497965014802	ATP binding site [chemical binding]; other site
497965014803	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
497965014804	phosphoenolpyruvate synthase; Validated; Region: PRK06241
497965014805	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
497965014806	SPX domain-containing protein [Signal transduction mechanisms]; Region: COG5408
497965014807	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
497965014808	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965014809	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
497965014810	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965014811	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
497965014812	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
497965014813	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
497965014814	active site
497965014815	dimer interface [polypeptide binding]; other site
497965014816	catalytic residue [active]
497965014817	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
497965014818	Ca2+ binding site [ion binding]; other site
497965014819	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965014820	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
497965014821	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
497965014822	active site
497965014823	metal binding site [ion binding]; metal-binding site
497965014824	Response regulator receiver domain; Region: Response_reg; pfam00072
497965014825	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965014826	active site
497965014827	phosphorylation site [posttranslational modification]
497965014828	intermolecular recognition site; other site
497965014829	dimerization interface [polypeptide binding]; other site
497965014830	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965014831	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965014832	dimer interface [polypeptide binding]; other site
497965014833	phosphorylation site [posttranslational modification]
497965014834	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
497965014835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965014836	ATP binding site [chemical binding]; other site
497965014837	Mg2+ binding site [ion binding]; other site
497965014838	G-X-G motif; other site
497965014839	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965014840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965014841	active site
497965014842	phosphorylation site [posttranslational modification]
497965014843	intermolecular recognition site; other site
497965014844	dimerization interface [polypeptide binding]; other site
497965014845	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965014846	dimer interface [polypeptide binding]; other site
497965014847	phosphorylation site [posttranslational modification]
497965014848	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965014849	ATP binding site [chemical binding]; other site
497965014850	Mg2+ binding site [ion binding]; other site
497965014851	G-X-G motif; other site
497965014852	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965014853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965014854	active site
497965014855	phosphorylation site [posttranslational modification]
497965014856	intermolecular recognition site; other site
497965014857	dimerization interface [polypeptide binding]; other site
497965014858	PAS fold; Region: PAS_3; pfam08447
497965014859	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014860	putative active site [active]
497965014861	heme pocket [chemical binding]; other site
497965014862	PAS fold; Region: PAS_4; pfam08448
497965014863	PAS domain S-box; Region: sensory_box; TIGR00229
497965014864	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014865	putative active site [active]
497965014866	heme pocket [chemical binding]; other site
497965014867	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965014868	dimer interface [polypeptide binding]; other site
497965014869	phosphorylation site [posttranslational modification]
497965014870	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965014871	ATP binding site [chemical binding]; other site
497965014872	Mg2+ binding site [ion binding]; other site
497965014873	G-X-G motif; other site
497965014874	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965014875	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965014876	active site
497965014877	phosphorylation site [posttranslational modification]
497965014878	intermolecular recognition site; other site
497965014879	dimerization interface [polypeptide binding]; other site
497965014880	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965014881	DNA binding residues [nucleotide binding]
497965014882	dimerization interface [polypeptide binding]; other site
497965014883	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497965014884	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965014885	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
497965014886	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
497965014887	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965014888	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
497965014889	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965014890	DNA binding residues [nucleotide binding]
497965014891	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
497965014892	calcium/proton exchanger (cax); Region: cax; TIGR00378
497965014893	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
497965014894	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
497965014895	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
497965014896	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
497965014897	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
497965014898	RNase E interface [polypeptide binding]; other site
497965014899	trimer interface [polypeptide binding]; other site
497965014900	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
497965014901	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
497965014902	RNase E interface [polypeptide binding]; other site
497965014903	trimer interface [polypeptide binding]; other site
497965014904	active site
497965014905	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
497965014906	putative nucleic acid binding region [nucleotide binding]; other site
497965014907	G-X-X-G motif; other site
497965014908	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
497965014909	RNA binding site [nucleotide binding]; other site
497965014910	domain interface; other site
497965014911	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
497965014912	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
497965014913	shikimate kinase; Reviewed; Region: aroK; PRK00131
497965014914	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
497965014915	ADP binding site [chemical binding]; other site
497965014916	magnesium binding site [ion binding]; other site
497965014917	putative shikimate binding site; other site
497965014918	DNA polymerase processivity factor (UL42); Region: Herpes_UL42; pfam02282
497965014919	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
497965014920	aromatic acid decarboxylase; Validated; Region: PRK05920
497965014921	Flavoprotein; Region: Flavoprotein; pfam02441
497965014922	HEAT repeats; Region: HEAT_2; pfam13646
497965014923	HEAT repeats; Region: HEAT_2; pfam13646
497965014924	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
497965014925	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965014926	Coenzyme A binding pocket [chemical binding]; other site
497965014927	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965014928	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497965014929	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
497965014930	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
497965014931	hydroxyglutarate oxidase; Provisional; Region: PRK11728
497965014932	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
497965014933	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
497965014934	Multicopper oxidase; Region: Cu-oxidase; pfam00394
497965014935	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
497965014936	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965014937	Probable transposase; Region: OrfB_IS605; pfam01385
497965014938	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
497965014939	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
497965014940	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
497965014941	protein binding site [polypeptide binding]; other site
497965014942	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
497965014943	Domain interface; other site
497965014944	Peptide binding site; other site
497965014945	Active site tetrad [active]
497965014946	RRXRR protein; Region: RRXRR; pfam14239
497965014947	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
497965014948	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
497965014949	active site
497965014950	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
497965014951	tetramer interface [polypeptide binding]; other site
497965014952	dimer interface [polypeptide binding]; other site
497965014953	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
497965014954	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
497965014955	nucleotide binding site [chemical binding]; other site
497965014956	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965014957	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965014958	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965014959	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014960	putative active site [active]
497965014961	heme pocket [chemical binding]; other site
497965014962	PAS domain S-box; Region: sensory_box; TIGR00229
497965014963	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965014964	putative active site [active]
497965014965	heme pocket [chemical binding]; other site
497965014966	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965014967	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965014968	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965014969	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965014970	metal binding site [ion binding]; metal-binding site
497965014971	active site
497965014972	I-site; other site
497965014973	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
497965014974	active site
497965014975	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
497965014976	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
497965014977	putative catalytic cysteine [active]
497965014978	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
497965014979	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965014980	ATP binding site [chemical binding]; other site
497965014981	putative Mg++ binding site [ion binding]; other site
497965014982	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965014983	nucleotide binding region [chemical binding]; other site
497965014984	ATP-binding site [chemical binding]; other site
497965014985	SnoaL-like domain; Region: SnoaL_2; pfam12680
497965014986	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
497965014987	Glycoprotease family; Region: Peptidase_M22; pfam00814
497965014988	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965014989	S-adenosylmethionine binding site [chemical binding]; other site
497965014990	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965014991	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965014992	structural tetrad; other site
497965014993	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
497965014994	MgtE intracellular N domain; Region: MgtE_N; smart00924
497965014995	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
497965014996	Divalent cation transporter; Region: MgtE; pfam01769
497965014997	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965014998	putative active site [active]
497965014999	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
497965015000	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
497965015001	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
497965015002	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965015003	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965015004	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965015005	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965015006	dimer interface [polypeptide binding]; other site
497965015007	phosphorylation site [posttranslational modification]
497965015008	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965015009	ATP binding site [chemical binding]; other site
497965015010	Mg2+ binding site [ion binding]; other site
497965015011	G-X-G motif; other site
497965015012	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
497965015013	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
497965015014	putative active site cavity [active]
497965015015	CheB methylesterase; Region: CheB_methylest; pfam01339
497965015016	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
497965015017	dimer interface [polypeptide binding]; other site
497965015018	substrate binding site [chemical binding]; other site
497965015019	metal binding sites [ion binding]; metal-binding site
497965015020	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
497965015021	ABC1 family; Region: ABC1; cl17513
497965015022	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
497965015023	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
497965015024	Walker A/P-loop; other site
497965015025	ATP binding site [chemical binding]; other site
497965015026	Q-loop/lid; other site
497965015027	ABC transporter signature motif; other site
497965015028	Walker B; other site
497965015029	D-loop; other site
497965015030	H-loop/switch region; other site
497965015031	Bacterial SH3 domain; Region: SH3_3; pfam08239
497965015032	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
497965015033	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
497965015034	active site
497965015035	metal binding site [ion binding]; metal-binding site
497965015036	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965015037	Probable transposase; Region: OrfB_IS605; pfam01385
497965015038	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965015039	Cupin domain; Region: Cupin_2; pfam07883
497965015040	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
497965015041	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
497965015042	putative catalytic cysteine [active]
497965015043	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
497965015044	homopentamer interface [polypeptide binding]; other site
497965015045	active site
497965015046	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
497965015047	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965015048	structural tetrad; other site
497965015049	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965015050	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965015051	structural tetrad; other site
497965015052	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965015053	structural tetrad; other site
497965015054	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965015055	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
497965015056	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
497965015057	FMN binding site [chemical binding]; other site
497965015058	active site
497965015059	substrate binding site [chemical binding]; other site
497965015060	catalytic residue [active]
497965015061	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
497965015062	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
497965015063	core domain interface [polypeptide binding]; other site
497965015064	delta subunit interface [polypeptide binding]; other site
497965015065	epsilon subunit interface [polypeptide binding]; other site
497965015066	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
497965015067	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
497965015068	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
497965015069	beta subunit interaction interface [polypeptide binding]; other site
497965015070	Walker A motif; other site
497965015071	ATP binding site [chemical binding]; other site
497965015072	Walker B motif; other site
497965015073	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
497965015074	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
497965015075	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
497965015076	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
497965015077	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
497965015078	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
497965015079	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
497965015080	F0F1 ATP synthase subunit C; Validated; Region: PRK07354
497965015081	ATP synthase CF0 A subunit; Region: atpI; CHL00046
497965015082	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
497965015083	ATP synthase I chain; Region: ATP_synt_I; pfam03899
497965015084	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965015085	TPR motif; other site
497965015086	TPR repeat; Region: TPR_11; pfam13414
497965015087	binding surface
497965015088	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965015089	putative active site [active]
497965015090	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
497965015091	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
497965015092	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
497965015093	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
497965015094	Walker A/P-loop; other site
497965015095	ATP binding site [chemical binding]; other site
497965015096	Q-loop/lid; other site
497965015097	ABC transporter signature motif; other site
497965015098	Walker B; other site
497965015099	D-loop; other site
497965015100	H-loop/switch region; other site
497965015101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965015102	dimer interface [polypeptide binding]; other site
497965015103	ABC-ATPase subunit interface; other site
497965015104	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
497965015105	XisI protein; Region: XisI; pfam08869
497965015106	XisH protein; Region: XisH; pfam08814
497965015107	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497965015108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965015109	S-adenosylmethionine binding site [chemical binding]; other site
497965015110	phycobillisome linker protein; Region: apcE; CHL00091
497965015111	Phycobilisome protein; Region: Phycobilisome; cl08227
497965015112	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
497965015113	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
497965015114	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
497965015115	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965015116	putative active site [active]
497965015117	Phycobilisome protein; Region: Phycobilisome; cl08227
497965015118	allophycocyanin beta subunit; Region: apcB; CHL00088
497965015119	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
497965015120	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497965015121	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965015122	non-specific DNA binding site [nucleotide binding]; other site
497965015123	salt bridge; other site
497965015124	sequence-specific DNA binding site [nucleotide binding]; other site
497965015125	ICEA Protein; Region: ICEA; pfam05315
497965015126	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
497965015127	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
497965015128	cofactor binding site; other site
497965015129	DNA binding site [nucleotide binding]
497965015130	substrate interaction site [chemical binding]; other site
497965015131	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
497965015132	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
497965015133	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
497965015134	Walker A/P-loop; other site
497965015135	ATP binding site [chemical binding]; other site
497965015136	Q-loop/lid; other site
497965015137	ABC transporter signature motif; other site
497965015138	Walker B; other site
497965015139	D-loop; other site
497965015140	H-loop/switch region; other site
497965015141	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
497965015142	Fasciclin domain; Region: Fasciclin; pfam02469
497965015143	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965015144	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965015145	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965015146	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
497965015147	EamA-like transporter family; Region: EamA; pfam00892
497965015148	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
497965015149	Photosystem II, DII subunit (also called Q(A)); Region: psbD; TIGR01152
497965015150	pheophytin binding site; other site
497965015151	chlorophyll binding site; other site
497965015152	quinone binding site; other site
497965015153	Fe binding site [ion binding]; other site
497965015154	hypothetical protein; Provisional; Region: PRK13683
497965015155	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
497965015156	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
497965015157	Walker A/P-loop; other site
497965015158	ATP binding site [chemical binding]; other site
497965015159	Q-loop/lid; other site
497965015160	ABC transporter signature motif; other site
497965015161	Walker B; other site
497965015162	D-loop; other site
497965015163	H-loop/switch region; other site
497965015164	YacP-like NYN domain; Region: NYN_YacP; pfam05991
497965015165	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
497965015166	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
497965015167	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
497965015168	[2Fe-2S] cluster binding site [ion binding]; other site
497965015169	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
497965015170	hydrophobic ligand binding site; other site
497965015171	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
497965015172	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
497965015173	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497965015174	catalytic residue [active]
497965015175	GH3 auxin-responsive promoter; Region: GH3; pfam03321
497965015176	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
497965015177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965015178	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497965015179	putative substrate translocation pore; other site
497965015180	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
497965015181	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
497965015182	putative NADP binding site [chemical binding]; other site
497965015183	putative substrate binding site [chemical binding]; other site
497965015184	active site
497965015185	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
497965015186	Fasciclin domain; Region: Fasciclin; pfam02469
497965015187	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497965015188	catalytic core [active]
497965015189	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965015190	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965015191	ligand binding site [chemical binding]; other site
497965015192	flexible hinge region; other site
497965015193	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
497965015194	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
497965015195	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
497965015196	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
497965015197	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
497965015198	putative active site [active]
497965015199	dimerization interface [polypeptide binding]; other site
497965015200	putative tRNAtyr binding site [nucleotide binding]; other site
497965015201	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
497965015202	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
497965015203	Resolvase, N terminal domain; Region: Resolvase; smart00857
497965015204	catalytic residues [active]
497965015205	catalytic nucleophile [active]
497965015206	methionine sulfoxide reductase A; Provisional; Region: PRK13014
497965015207	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
497965015208	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
497965015209	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
497965015210	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
497965015211	glutamine binding [chemical binding]; other site
497965015212	catalytic triad [active]
497965015213	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
497965015214	metal-binding heat shock protein; Provisional; Region: PRK00016
497965015215	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
497965015216	peptide chain release factor 2; Validated; Region: prfB; PRK00578
497965015217	This domain is found in peptide chain release factors; Region: PCRF; smart00937
497965015218	RF-1 domain; Region: RF-1; pfam00472
497965015219	TMAO/DMSO reductase; Reviewed; Region: PRK05363
497965015220	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
497965015221	Moco binding site; other site
497965015222	metal coordination site [ion binding]; other site
497965015223	Uncharacterized conserved protein [Function unknown]; Region: COG5607
497965015224	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965015225	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
497965015226	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
497965015227	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
497965015228	dimerization interface [polypeptide binding]; other site
497965015229	active site
497965015230	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
497965015231	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
497965015232	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
497965015233	SmpB-tmRNA interface; other site
497965015234	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
497965015235	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
497965015236	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
497965015237	PAS domain; Region: PAS_9; pfam13426
497965015238	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965015239	PAS domain; Region: PAS_9; pfam13426
497965015240	putative active site [active]
497965015241	heme pocket [chemical binding]; other site
497965015242	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
497965015243	CheB methylesterase; Region: CheB_methylest; pfam01339
497965015244	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
497965015245	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
497965015246	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
497965015247	active site
497965015248	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
497965015249	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
497965015250	putative active site pocket [active]
497965015251	4-fold oligomerization interface [polypeptide binding]; other site
497965015252	metal binding residues [ion binding]; metal-binding site
497965015253	3-fold/trimer interface [polypeptide binding]; other site
497965015254	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965015255	putative active site [active]
497965015256	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
497965015257	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497965015258	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965015259	homodimer interface [polypeptide binding]; other site
497965015260	catalytic residue [active]
497965015261	DDE superfamily endonuclease; Region: DDE_5; cl17874
497965015262	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
497965015263	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
497965015264	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
497965015265	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
497965015266	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
497965015267	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
497965015268	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
497965015269	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497965015270	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
497965015271	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965015272	putative active site [active]
497965015273	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
497965015274	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
497965015275	Aluminium resistance protein; Region: Alum_res; pfam06838
497965015276	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
497965015277	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497965015278	Di-iron ligands [ion binding]; other site
497965015279	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
497965015280	homodecamer interface [polypeptide binding]; other site
497965015281	GTP cyclohydrolase I; Provisional; Region: PLN03044
497965015282	active site
497965015283	putative catalytic site residues [active]
497965015284	zinc binding site [ion binding]; other site
497965015285	GTP-CH-I/GFRP interaction surface; other site
497965015286	short chain dehydrogenase; Provisional; Region: PRK07454
497965015287	classical (c) SDRs; Region: SDR_c; cd05233
497965015288	NAD(P) binding site [chemical binding]; other site
497965015289	active site
497965015290	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
497965015291	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
497965015292	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965015293	Probable transposase; Region: OrfB_IS605; pfam01385
497965015294	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
497965015295	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
497965015296	putative acyl-acceptor binding pocket; other site
497965015297	EamA-like transporter family; Region: EamA; pfam00892
497965015298	EamA-like transporter family; Region: EamA; pfam00892
497965015299	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
497965015300	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
497965015301	tandem repeat interface [polypeptide binding]; other site
497965015302	oligomer interface [polypeptide binding]; other site
497965015303	active site residues [active]
497965015304	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
497965015305	homotrimer interaction site [polypeptide binding]; other site
497965015306	active site
497965015307	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
497965015308	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
497965015309	Pantoate-beta-alanine ligase; Region: PanC; cd00560
497965015310	active site
497965015311	ATP-binding site [chemical binding]; other site
497965015312	pantoate-binding site; other site
497965015313	HXXH motif; other site
497965015314	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
497965015315	CMP-binding site; other site
497965015316	The sites determining sugar specificity; other site
497965015317	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
497965015318	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
497965015319	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
497965015320	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
497965015321	dimerization interface [polypeptide binding]; other site
497965015322	putative ATP binding site [chemical binding]; other site
497965015323	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
497965015324	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965015325	AAA domain; Region: AAA_21; pfam13304
497965015326	Walker A/P-loop; other site
497965015327	ATP binding site [chemical binding]; other site
497965015328	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
497965015329	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
497965015330	nucleotide binding site [chemical binding]; other site
497965015331	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
497965015332	active site
497965015333	catalytic residues [active]
497965015334	metal binding site [ion binding]; metal-binding site
497965015335	Riboflavin synthase alpha chain [Coenzyme metabolism]; Region: RibC; COG0307
497965015336	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
497965015337	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
497965015338	Surface antigen; Region: Bac_surface_Ag; pfam01103
497965015339	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
497965015340	haemagglutination activity domain; Region: Haemagg_act; pfam05860
497965015341	CHAT domain; Region: CHAT; cl17868
497965015342	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
497965015343	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
497965015344	Domain of unknown function (DUF370); Region: DUF370; cl00898
497965015345	Calx-beta domain; Region: Calx-beta; pfam03160
497965015346	Calx-beta domain; Region: Calx-beta; pfam03160
497965015347	legume lectins, lectin-like receptor kinases, arcelin, concanavalinA, and alpha-amylase inhibitor; Region: lectin_legume_LecRK_Arcelin_ConA; cd06899
497965015348	homodimer interaction site [polypeptide binding]; other site
497965015349	homotetramer interaction site [polypeptide binding]; other site
497965015350	N-linked glycosylation site; other site
497965015351	metal binding site [ion binding]; metal-binding site
497965015352	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
497965015353	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965015354	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
497965015355	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
497965015356	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
497965015357	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
497965015358	rod shape-determining protein MreC; Provisional; Region: PRK13922
497965015359	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
497965015360	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
497965015361	active site
497965015362	catalytic site [active]
497965015363	substrate binding site [chemical binding]; other site
497965015364	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965015365	non-specific DNA binding site [nucleotide binding]; other site
497965015366	salt bridge; other site
497965015367	sequence-specific DNA binding site [nucleotide binding]; other site
497965015368	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
497965015369	AAA domain; Region: AAA_25; pfam13481
497965015370	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497965015371	active site
497965015372	DNA binding site [nucleotide binding]
497965015373	Int/Topo IB signature motif; other site
497965015374	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
497965015375	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497965015376	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
497965015377	Walker A/P-loop; other site
497965015378	ATP binding site [chemical binding]; other site
497965015379	Q-loop/lid; other site
497965015380	ABC transporter signature motif; other site
497965015381	Walker B; other site
497965015382	D-loop; other site
497965015383	H-loop/switch region; other site
497965015384	Family description; Region: VCBS; pfam13517
497965015385	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965015386	TIGR03032 family protein; Region: TIGR03032
497965015387	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965015388	Coenzyme A binding pocket [chemical binding]; other site
497965015389	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
497965015390	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
497965015391	NAD binding site [chemical binding]; other site
497965015392	homodimer interface [polypeptide binding]; other site
497965015393	active site
497965015394	substrate binding site [chemical binding]; other site
497965015395	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
497965015396	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
497965015397	active site
497965015398	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965015399	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
497965015400	active site
497965015401	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
497965015402	LicD family; Region: LicD; pfam04991
497965015403	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
497965015404	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965015405	S-adenosylmethionine binding site [chemical binding]; other site
497965015406	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
497965015407	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
497965015408	active site
497965015409	metal-binding site
497965015410	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
497965015411	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497965015412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965015413	homodimer interface [polypeptide binding]; other site
497965015414	catalytic residue [active]
497965015415	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965015416	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
497965015417	active site
497965015418	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965015419	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965015420	active site
497965015421	hypothetical protein; Provisional; Region: PRK07208
497965015422	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965015423	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
497965015424	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
497965015425	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
497965015426	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
497965015427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965015428	S-adenosylmethionine binding site [chemical binding]; other site
497965015429	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
497965015430	polymerase nucleotide-binding site; other site
497965015431	DNA-binding residues [nucleotide binding]; DNA binding site
497965015432	nucleotide binding site [chemical binding]; other site
497965015433	primase nucleotide-binding site [nucleotide binding]; other site
497965015434	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
497965015435	AAA domain; Region: AAA_31; pfam13614
497965015436	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965015437	P-loop; other site
497965015438	Magnesium ion binding site [ion binding]; other site
497965015439	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965015440	Magnesium ion binding site [ion binding]; other site
497965015441	Condensation domain; Region: Condensation; pfam00668
497965015442	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
497965015443	Calx-beta domain; Region: Calx-beta; pfam03160
497965015444	CARDB; Region: CARDB; pfam07705
497965015445	CARDB; Region: CARDB; pfam07705
497965015446	CARDB; Region: CARDB; pfam07705
497965015447	CARDB; Region: CARDB; pfam07705
497965015448	CARDB; Region: CARDB; pfam07705
497965015449	CARDB; Region: CARDB; pfam07705
497965015450	CARDB; Region: CARDB; pfam07705
497965015451	Uncharacterized conserved protein [Function unknown]; Region: COG1572
497965015452	CARDB; Region: CARDB; pfam07705
497965015453	CARDB; Region: CARDB; pfam07705
497965015454	CARDB; Region: CARDB; pfam07705
497965015455	CARDB; Region: CARDB; pfam07705
497965015456	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
497965015457	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
497965015458	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
497965015459	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965015460	Cadherin repeat-like domain; Region: CA_like; cl15786
497965015461	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
497965015462	Transposase; Region: DDE_Tnp_ISL3; pfam01610
497965015463	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
497965015464	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965015465	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
497965015466	Walker A motif; other site
497965015467	ATP binding site [chemical binding]; other site
497965015468	Walker B motif; other site
497965015469	arginine finger; other site
497965015470	Domain of unknown function DUF87; Region: DUF87; pfam01935
497965015471	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
497965015472	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
497965015473	Transposase domain (DUF772); Region: DUF772; pfam05598
497965015474	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
497965015475	AAA-like domain; Region: AAA_10; pfam12846
497965015476	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965015477	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965015478	DNA binding residues [nucleotide binding]
497965015479	dimerization interface [polypeptide binding]; other site
497965015480	Transcriptional activator [Transcription]; Region: ChrR; COG3806
497965015481	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
497965015482	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
497965015483	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
497965015484	putative active site [active]
497965015485	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
497965015486	active site
497965015487	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
497965015488	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
497965015489	cofactor binding site; other site
497965015490	DNA binding site [nucleotide binding]
497965015491	substrate interaction site [chemical binding]; other site
497965015492	DdrB-like protein; Region: DdrB; pfam12747
497965015493	DEAD-like helicases superfamily; Region: DEXDc; smart00487
497965015494	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
497965015495	Family description; Region: UvrD_C_2; pfam13538
497965015496	ParB-like nuclease domain; Region: ParB; smart00470
497965015497	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
497965015498	active site
497965015499	putative DNA-binding cleft [nucleotide binding]; other site
497965015500	dimer interface [polypeptide binding]; other site
497965015501	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497965015502	active site
497965015503	DNA binding site [nucleotide binding]
497965015504	Int/Topo IB signature motif; other site
497965015505	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965015506	active site
497965015507	phosphorylation site [posttranslational modification]
497965015508	intermolecular recognition site; other site
497965015509	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
497965015510	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
497965015511	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
497965015512	Mg binding site [ion binding]; other site
497965015513	nucleotide binding site [chemical binding]; other site
497965015514	putative protofilament interface [polypeptide binding]; other site
497965015515	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
497965015516	RNA/DNA hybrid binding site [nucleotide binding]; other site
497965015517	active site
497965015518	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
497965015519	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
497965015520	dimer interface [polypeptide binding]; other site
497965015521	ssDNA binding site [nucleotide binding]; other site
497965015522	tetramer (dimer of dimers) interface [polypeptide binding]; other site
497965015523	YcfA-like protein; Region: YcfA; cl00752
497965015524	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
497965015525	Uncharacterized conserved protein [Function unknown]; Region: COG5464
497965015526	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
497965015527	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
497965015528	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
497965015529	DEAD-like helicases superfamily; Region: DEXDc; smart00487
497965015530	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965015531	ATP binding site [chemical binding]; other site
497965015532	putative Mg++ binding site [ion binding]; other site
497965015533	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965015534	nucleotide binding region [chemical binding]; other site
497965015535	ATP-binding site [chemical binding]; other site
497965015536	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
497965015537	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
497965015538	active site
497965015539	catalytic site [active]
497965015540	substrate binding site [chemical binding]; other site
497965015541	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
497965015542	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497965015543	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965015544	non-specific DNA binding site [nucleotide binding]; other site
497965015545	salt bridge; other site
497965015546	sequence-specific DNA binding site [nucleotide binding]; other site
497965015547	AntA/AntB antirepressor; Region: AntA; cl01430
497965015548	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
497965015549	AAA domain; Region: AAA_25; pfam13481
497965015550	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965015551	ATP binding site [chemical binding]; other site
497965015552	Walker B motif; other site
497965015553	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
497965015554	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
497965015555	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965015556	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
497965015557	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
497965015558	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965015559	motif II; other site
497965015560	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965015561	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
497965015562	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
497965015563	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
497965015564	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
497965015565	active site
497965015566	GIY-YIG motif/motif A; other site
497965015567	catalytic site [active]
497965015568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965015569	S-adenosylmethionine binding site [chemical binding]; other site
497965015570	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
497965015571	polymerase nucleotide-binding site; other site
497965015572	DNA-binding residues [nucleotide binding]; DNA binding site
497965015573	nucleotide binding site [chemical binding]; other site
497965015574	primase nucleotide-binding site [nucleotide binding]; other site
497965015575	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
497965015576	AAA domain; Region: AAA_31; pfam13614
497965015577	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965015578	P-loop; other site
497965015579	Magnesium ion binding site [ion binding]; other site
497965015580	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965015581	Magnesium ion binding site [ion binding]; other site
497965015582	RNB domain; Region: RNB; pfam00773
497965015583	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
497965015584	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
497965015585	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965015586	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
497965015587	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
497965015588	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
497965015589	dimer interface [polypeptide binding]; other site
497965015590	ssDNA binding site [nucleotide binding]; other site
497965015591	tetramer (dimer of dimers) interface [polypeptide binding]; other site
497965015592	Mucin-like glycoprotein; Region: Mucin; pfam01456
497965015593	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
497965015594	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
497965015595	putative active site [active]
497965015596	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
497965015597	Mg binding site [ion binding]; other site
497965015598	nucleotide binding site [chemical binding]; other site
497965015599	putative protofilament interface [polypeptide binding]; other site
497965015600	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
497965015601	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
497965015602	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965015603	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965015604	DNA binding residues [nucleotide binding]
497965015605	dimerization interface [polypeptide binding]; other site
497965015606	AAA-like domain; Region: AAA_10; pfam12846
497965015607	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
497965015608	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
497965015609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965015610	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
497965015611	Walker A motif; other site
497965015612	ATP binding site [chemical binding]; other site
497965015613	Walker B motif; other site
497965015614	arginine finger; other site
497965015615	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
497965015616	putative active site [active]
497965015617	DDE superfamily endonuclease; Region: DDE_5; cl17874
497965015618	DdrB-like protein; Region: DdrB; pfam12747
497965015619	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
497965015620	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965015621	ATP binding site [chemical binding]; other site
497965015622	putative Mg++ binding site [ion binding]; other site
497965015623	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965015624	nucleotide binding region [chemical binding]; other site
497965015625	ATP-binding site [chemical binding]; other site
497965015626	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
497965015627	DnaJ domain; Region: DnaJ; pfam00226
497965015628	ParB-like nuclease domain; Region: ParBc; cl02129
497965015629	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
497965015630	active site
497965015631	putative DNA-binding cleft [nucleotide binding]; other site
497965015632	dimer interface [polypeptide binding]; other site
497965015633	integrase/recombinase; Provisional; Region: PRK15417
497965015634	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497965015635	active site
497965015636	DNA binding site [nucleotide binding]
497965015637	Int/Topo IB signature motif; other site
497965015638	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
497965015639	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
497965015640	putative ligand binding site [chemical binding]; other site
497965015641	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965015642	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965015643	structural tetrad; other site
497965015644	TIR domain; Region: TIR_2; pfam13676
497965015645	TIR domain; Region: TIR_2; pfam13676
497965015646	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
497965015647	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497965015648	active site
497965015649	DNA binding site [nucleotide binding]
497965015650	Int/Topo IB signature motif; other site
497965015651	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965015652	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965015653	Probable transposase; Region: OrfB_IS605; pfam01385
497965015654	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965015655	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
497965015656	Part of AAA domain; Region: AAA_19; pfam13245
497965015657	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
497965015658	AAA domain; Region: AAA_12; pfam13087
497965015659	Uncharacterized conserved protein [Function unknown]; Region: COG2361
497965015660	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
497965015661	active site
497965015662	NTP binding site [chemical binding]; other site
497965015663	metal binding triad [ion binding]; metal-binding site
497965015664	antibiotic binding site [chemical binding]; other site
497965015665	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
497965015666	ParB-like nuclease domain; Region: ParBc; pfam02195
497965015667	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
497965015668	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965015669	P-loop; other site
497965015670	Magnesium ion binding site [ion binding]; other site
497965015671	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965015672	Magnesium ion binding site [ion binding]; other site
497965015673	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965015674	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965015675	active site
497965015676	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
497965015677	polymerase nucleotide-binding site; other site
497965015678	DNA-binding residues [nucleotide binding]; DNA binding site
497965015679	nucleotide binding site [chemical binding]; other site
497965015680	primase nucleotide-binding site [nucleotide binding]; other site
497965015681	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
497965015682	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
497965015683	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965015684	non-specific DNA binding site [nucleotide binding]; other site
497965015685	salt bridge; other site
497965015686	sequence-specific DNA binding site [nucleotide binding]; other site
497965015687	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965015688	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965015689	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965015690	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965015691	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965015692	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965015693	Tubulin like; Region: Tubulin_2; pfam13809
497965015694	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
497965015695	V-ATPase subunit C; Region: V-ATPase_C; cl15414
497965015696	YfhG lipoprotein; Region: Lipoprotein_20; cl08141
497965015697	multiple promoter invertase; Provisional; Region: mpi; PRK13413
497965015698	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
497965015699	catalytic residues [active]
497965015700	catalytic nucleophile [active]
497965015701	Presynaptic Site I dimer interface [polypeptide binding]; other site
497965015702	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
497965015703	Synaptic Flat tetramer interface [polypeptide binding]; other site
497965015704	Synaptic Site I dimer interface [polypeptide binding]; other site
497965015705	DNA binding site [nucleotide binding]
497965015706	Helix-turn-helix domain; Region: HTH_28; pfam13518
497965015707	Integrase core domain; Region: rve; pfam00665
497965015708	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
497965015709	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965015710	Walker A/P-loop; other site
497965015711	ATP binding site [chemical binding]; other site
497965015712	Q-loop/lid; other site
497965015713	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965015714	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965015715	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
497965015716	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
497965015717	SNF2 Helicase protein; Region: DUF3670; pfam12419
497965015718	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965015719	ATP binding site [chemical binding]; other site
497965015720	putative Mg++ binding site [ion binding]; other site
497965015721	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965015722	nucleotide binding region [chemical binding]; other site
497965015723	ATP-binding site [chemical binding]; other site
497965015724	BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463
497965015725	AAA domain; Region: AAA_11; pfam13086
497965015726	Part of AAA domain; Region: AAA_19; pfam13245
497965015727	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
497965015728	AAA domain; Region: AAA_12; pfam13087
497965015729	ParB-like nuclease domain; Region: ParB; smart00470
497965015730	KorB domain; Region: KorB; pfam08535
497965015731	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
497965015732	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497965015733	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965015734	Magnesium ion binding site [ion binding]; other site
497965015735	transcriptional regulator MalT; Provisional; Region: PRK04841
497965015736	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
497965015737	CHAT domain; Region: CHAT; cl17868
497965015738	AAA ATPase domain; Region: AAA_16; pfam13191
497965015739	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965015740	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965015741	structural tetrad; other site
497965015742	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965015743	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965015744	structural tetrad; other site
497965015745	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965015746	binding surface
497965015747	TPR motif; other site
497965015748	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965015749	active site
497965015750	catalytic residues [active]
497965015751	DNA binding site [nucleotide binding]
497965015752	Int/Topo IB signature motif; other site
497965015753	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
497965015754	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
497965015755	Coenzyme A binding pocket [chemical binding]; other site
497965015756	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
497965015757	Helix-turn-helix domain; Region: HTH_17; cl17695
497965015758	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
497965015759	nucleotide binding site [chemical binding]; other site
497965015760	polymerase nucleotide-binding site; other site
497965015761	primase nucleotide-binding site [nucleotide binding]; other site
497965015762	DNA-binding residues [nucleotide binding]; DNA binding site
497965015763	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965015764	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965015765	Probable transposase; Region: OrfB_IS605; pfam01385
497965015766	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965015767	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965015768	putative active site [active]
497965015769	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
497965015770	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965015771	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965015772	Probable transposase; Region: OrfB_IS605; pfam01385
497965015773	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965015774	PIN domain; Region: PIN_3; pfam13470
497965015775	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
497965015776	TrwC relaxase; Region: TrwC; pfam08751
497965015777	AAA domain; Region: AAA_30; pfam13604
497965015778	Family description; Region: UvrD_C_2; pfam13538
497965015779	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
497965015780	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
497965015781	PAS fold; Region: PAS; pfam00989
497965015782	GAF domain; Region: GAF_2; pfam13185
497965015783	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965015784	PAS fold; Region: PAS_4; pfam08448
497965015785	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965015786	putative active site [active]
497965015787	heme pocket [chemical binding]; other site
497965015788	PAS domain S-box; Region: sensory_box; TIGR00229
497965015789	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965015790	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965015791	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965015792	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965015793	putative active site [active]
497965015794	heme pocket [chemical binding]; other site
497965015795	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965015796	GAF domain; Region: GAF; pfam01590
497965015797	PAS domain S-box; Region: sensory_box; TIGR00229
497965015798	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965015799	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
497965015800	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965015801	ATP binding site [chemical binding]; other site
497965015802	Mg2+ binding site [ion binding]; other site
497965015803	G-X-G motif; other site
497965015804	Response regulator receiver domain; Region: Response_reg; pfam00072
497965015805	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965015806	active site
497965015807	phosphorylation site [posttranslational modification]
497965015808	intermolecular recognition site; other site
497965015809	dimerization interface [polypeptide binding]; other site
497965015810	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965015811	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965015812	dimer interface [polypeptide binding]; other site
497965015813	phosphorylation site [posttranslational modification]
497965015814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965015815	ATP binding site [chemical binding]; other site
497965015816	Mg2+ binding site [ion binding]; other site
497965015817	G-X-G motif; other site
497965015818	GAF domain; Region: GAF_3; pfam13492
497965015819	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965015820	dimer interface [polypeptide binding]; other site
497965015821	phosphorylation site [posttranslational modification]
497965015822	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965015823	ATP binding site [chemical binding]; other site
497965015824	Mg2+ binding site [ion binding]; other site
497965015825	G-X-G motif; other site
497965015826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965015827	active site
497965015828	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965015829	phosphorylation site [posttranslational modification]
497965015830	intermolecular recognition site; other site
497965015831	dimerization interface [polypeptide binding]; other site
497965015832	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965015833	dimer interface [polypeptide binding]; other site
497965015834	phosphorylation site [posttranslational modification]
497965015835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965015836	ATP binding site [chemical binding]; other site
497965015837	Mg2+ binding site [ion binding]; other site
497965015838	G-X-G motif; other site
497965015839	PAS fold; Region: PAS; pfam00989
497965015840	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965015841	putative active site [active]
497965015842	heme pocket [chemical binding]; other site
497965015843	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965015844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965015845	active site
497965015846	phosphorylation site [posttranslational modification]
497965015847	intermolecular recognition site; other site
497965015848	dimerization interface [polypeptide binding]; other site
497965015849	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784
497965015850	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
497965015851	protein-splicing catalytic site; other site
497965015852	thioester formation/cholesterol transfer; other site
497965015853	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
497965015854	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
497965015855	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
497965015856	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
497965015857	LVIVD repeat; Region: LVIVD; pfam08309
497965015858	LVIVD repeat; Region: LVIVD; pfam08309
497965015859	LVIVD repeat; Region: LVIVD; pfam08309
497965015860	LVIVD repeat; Region: LVIVD; pfam08309
497965015861	LVIVD repeat; Region: LVIVD; pfam08309
497965015862	LVIVD repeat; Region: LVIVD; pfam08309
497965015863	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965015864	Ca2+ binding site [ion binding]; other site
497965015865	LVIVD repeat; Region: LVIVD; pfam08309
497965015866	LVIVD repeat; Region: LVIVD; pfam08309
497965015867	LVIVD repeat; Region: LVIVD; pfam08309
497965015868	LVIVD repeat; Region: LVIVD; pfam08309
497965015869	LVIVD repeat; Region: LVIVD; pfam08309
497965015870	LVIVD repeat; Region: LVIVD; pfam08309
497965015871	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965015872	Ca2+ binding site [ion binding]; other site
497965015873	LVIVD repeat; Region: LVIVD; pfam08309
497965015874	LVIVD repeat; Region: LVIVD; pfam08309
497965015875	Uncharacterized conserved protein [Function unknown]; Region: COG5276
497965015876	LVIVD repeat; Region: LVIVD; pfam08309
497965015877	LVIVD repeat; Region: LVIVD; pfam08309
497965015878	LVIVD repeat; Region: LVIVD; pfam08309
497965015879	LVIVD repeat; Region: LVIVD; pfam08309
497965015880	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965015881	Ca2+ binding site [ion binding]; other site
497965015882	LVIVD repeat; Region: LVIVD; pfam08309
497965015883	LVIVD repeat; Region: LVIVD; pfam08309
497965015884	LVIVD repeat; Region: LVIVD; pfam08309
497965015885	LVIVD repeat; Region: LVIVD; pfam08309
497965015886	LVIVD repeat; Region: LVIVD; pfam08309
497965015887	LVIVD repeat; Region: LVIVD; pfam08309
497965015888	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
497965015889	active site
497965015890	Calx-beta domain; Region: Calx-beta; cl02522
497965015891	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497965015892	Peptidase family M23; Region: Peptidase_M23; pfam01551
497965015893	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497965015894	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965015895	S-adenosylmethionine binding site [chemical binding]; other site
497965015896	HPP family; Region: HPP; pfam04982
497965015897	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
497965015898	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
497965015899	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
497965015900	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
497965015901	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
497965015902	CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159
497965015903	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869
497965015904	CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712
497965015905	CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174
497965015906	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
497965015907	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
497965015908	WYL domain; Region: WYL; pfam13280
497965015909	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
497965015910	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
497965015911	active site
497965015912	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
497965015913	Domain interface; other site
497965015914	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
497965015915	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
497965015916	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965015917	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965015918	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965015919	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965015920	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
497965015921	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965015922	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965015923	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
497965015924	Ferritin-like; Region: Ferritin-like; pfam12902
497965015925	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
497965015926	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965015927	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
497965015928	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
497965015929	Uncharacterized conserved protein [Function unknown]; Region: COG1359
497965015930	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669
497965015931	active site
497965015932	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
497965015933	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
497965015934	conserved cys residue [active]
497965015935	Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250
497965015936	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
497965015937	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
497965015938	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
497965015939	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
497965015940	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
497965015941	Metal-binding active site; metal-binding site
497965015942	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
497965015943	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
497965015944	MOSC domain; Region: MOSC; pfam03473
497965015945	hypothetical protein; Provisional; Region: PRK07206
497965015946	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
497965015947	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
497965015948	[2Fe-2S] cluster binding site [ion binding]; other site
497965015949	iron-sulfur cluster [ion binding]; other site
497965015950	Cupin domain; Region: Cupin_2; pfam07883
497965015951	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
497965015952	putative lipid kinase; Reviewed; Region: PRK00861
497965015953	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
497965015954	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
497965015955	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965015956	NAD(P) binding site [chemical binding]; other site
497965015957	active site
497965015958	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
497965015959	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
497965015960	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
497965015961	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497965015962	Soluble P-type ATPase [General function prediction only]; Region: COG4087
497965015963	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
497965015964	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
497965015965	active site
497965015966	substrate binding site [chemical binding]; other site
497965015967	metal binding site [ion binding]; metal-binding site
497965015968	potential frameshift: common BLAST hit: gi|188581620|ref|YP_001925065.1| GLUG domain protein
497965015969	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
497965015970	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
497965015971	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
497965015972	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965015973	MgtC family; Region: MgtC; pfam02308
497965015974	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
497965015975	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497965015976	TPR repeat; Region: TPR_11; pfam13414
497965015977	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965015978	binding surface
497965015979	TPR motif; other site
497965015980	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965015981	binding surface
497965015982	TPR repeat; Region: TPR_11; pfam13414
497965015983	TPR motif; other site
497965015984	TPR repeat; Region: TPR_11; pfam13414
497965015985	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965015986	binding surface
497965015987	TPR motif; other site
497965015988	TPR repeat; Region: TPR_11; pfam13414
497965015989	TPR repeat; Region: TPR_11; pfam13414
497965015990	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965015991	binding surface
497965015992	TPR motif; other site
497965015993	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
497965015994	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
497965015995	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
497965015996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965015997	dimer interface [polypeptide binding]; other site
497965015998	conserved gate region; other site
497965015999	putative PBP binding loops; other site
497965016000	ABC-ATPase subunit interface; other site
497965016001	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965016002	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
497965016003	Walker A/P-loop; other site
497965016004	ATP binding site [chemical binding]; other site
497965016005	Q-loop/lid; other site
497965016006	ABC transporter signature motif; other site
497965016007	Walker B; other site
497965016008	D-loop; other site
497965016009	H-loop/switch region; other site
497965016010	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
497965016011	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
497965016012	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
497965016013	classical (c) SDRs; Region: SDR_c; cd05233
497965016014	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
497965016015	NAD(P) binding site [chemical binding]; other site
497965016016	active site
497965016017	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965016018	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
497965016019	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
497965016020	Fasciclin domain; Region: Fasciclin; pfam02469
497965016021	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
497965016022	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
497965016023	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
497965016024	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
497965016025	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
497965016026	glucose-1-dehydrogenase; Provisional; Region: PRK08936
497965016027	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
497965016028	NAD binding site [chemical binding]; other site
497965016029	homodimer interface [polypeptide binding]; other site
497965016030	active site
497965016031	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497965016032	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
497965016033	active site
497965016034	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497965016035	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
497965016036	active site
497965016037	metal binding site [ion binding]; metal-binding site
497965016038	Predicted membrane protein [Function unknown]; Region: COG4244
497965016039	Predicted membrane protein [Function unknown]; Region: COG4244
497965016040	Cupin domain; Region: Cupin_2; cl17218
497965016041	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
497965016042	dimerization interface [polypeptide binding]; other site
497965016043	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965016044	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965016045	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965016046	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
497965016047	NADH(P)-binding; Region: NAD_binding_10; pfam13460
497965016048	NAD(P) binding site [chemical binding]; other site
497965016049	putative active site [active]
497965016050	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
497965016051	iron-sulfur cluster [ion binding]; other site
497965016052	[2Fe-2S] cluster binding site [ion binding]; other site
497965016053	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
497965016054	VIT family; Region: VIT1; pfam01988
497965016055	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
497965016056	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
497965016057	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
497965016058	AAA-like domain; Region: AAA_10; pfam12846
497965016059	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
497965016060	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
497965016061	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
497965016062	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
497965016063	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016064	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
497965016065	Chain length determinant protein; Region: Wzz; pfam02706
497965016066	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
497965016067	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
497965016068	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497965016069	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
497965016070	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
497965016071	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
497965016072	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
497965016073	Walker A/P-loop; other site
497965016074	ATP binding site [chemical binding]; other site
497965016075	Q-loop/lid; other site
497965016076	ABC transporter signature motif; other site
497965016077	Walker B; other site
497965016078	D-loop; other site
497965016079	H-loop/switch region; other site
497965016080	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
497965016081	putative carbohydrate binding site [chemical binding]; other site
497965016082	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
497965016083	putative trimer interface [polypeptide binding]; other site
497965016084	putative active site [active]
497965016085	putative substrate binding site [chemical binding]; other site
497965016086	putative CoA binding site [chemical binding]; other site
497965016087	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
497965016088	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
497965016089	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
497965016090	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
497965016091	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
497965016092	inhibitor-cofactor binding pocket; inhibition site
497965016093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965016094	catalytic residue [active]
497965016095	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
497965016096	trimer interface [polypeptide binding]; other site
497965016097	active site
497965016098	substrate binding site [chemical binding]; other site
497965016099	CoA binding site [chemical binding]; other site
497965016100	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
497965016101	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965016102	NAD(P) binding site [chemical binding]; other site
497965016103	active site
497965016104	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
497965016105	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
497965016106	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
497965016107	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
497965016108	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
497965016109	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
497965016110	inhibitor-cofactor binding pocket; inhibition site
497965016111	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497965016112	catalytic residue [active]
497965016113	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016114	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
497965016115	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
497965016116	active site
497965016117	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016118	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
497965016119	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965016120	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016121	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016122	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965016123	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016124	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
497965016125	putative ADP-binding pocket [chemical binding]; other site
497965016126	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965016127	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016128	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965016129	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016130	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016131	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965016132	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016133	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
497965016134	putative ADP-binding pocket [chemical binding]; other site
497965016135	Uncharacterized conserved protein [Function unknown]; Region: COG1434
497965016136	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
497965016137	putative active site [active]
497965016138	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
497965016139	The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843
497965016140	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
497965016141	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
497965016142	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
497965016143	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
497965016144	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
497965016145	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
497965016146	putative sugar binding sites [chemical binding]; other site
497965016147	Q-X-W motif; other site
497965016148	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
497965016149	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
497965016150	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016151	putative ADP-binding pocket [chemical binding]; other site
497965016152	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965016153	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965016154	active site
497965016155	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497965016156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965016157	S-adenosylmethionine binding site [chemical binding]; other site
497965016158	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
497965016159	putative active site [active]
497965016160	putative metal binding site [ion binding]; other site
497965016161	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497965016162	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497965016163	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
497965016164	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
497965016165	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497965016166	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965016167	Walker A/P-loop; other site
497965016168	ATP binding site [chemical binding]; other site
497965016169	Q-loop/lid; other site
497965016170	ABC transporter signature motif; other site
497965016171	Walker B; other site
497965016172	D-loop; other site
497965016173	H-loop/switch region; other site
497965016174	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
497965016175	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965016176	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
497965016177	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
497965016178	putative NAD(P) binding site [chemical binding]; other site
497965016179	putative active site [active]
497965016180	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497965016181	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965016182	S-adenosylmethionine binding site [chemical binding]; other site
497965016183	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497965016184	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
497965016185	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
497965016186	Predicted flavoprotein [General function prediction only]; Region: COG0431
497965016187	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
497965016188	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
497965016189	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
497965016190	Multicopper oxidase; Region: Cu-oxidase; pfam00394
497965016191	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
497965016192	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
497965016193	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
497965016194	PBP superfamily domain; Region: PBP_like_2; cl17296
497965016195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965016196	dimer interface [polypeptide binding]; other site
497965016197	conserved gate region; other site
497965016198	putative PBP binding loops; other site
497965016199	ABC-ATPase subunit interface; other site
497965016200	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
497965016201	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497965016202	dimer interface [polypeptide binding]; other site
497965016203	conserved gate region; other site
497965016204	putative PBP binding loops; other site
497965016205	ABC-ATPase subunit interface; other site
497965016206	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
497965016207	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
497965016208	Walker A/P-loop; other site
497965016209	ATP binding site [chemical binding]; other site
497965016210	Q-loop/lid; other site
497965016211	ABC transporter signature motif; other site
497965016212	Walker B; other site
497965016213	D-loop; other site
497965016214	H-loop/switch region; other site
497965016215	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
497965016216	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497965016217	catalytic core [active]
497965016218	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497965016219	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965016220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965016221	active site
497965016222	phosphorylation site [posttranslational modification]
497965016223	intermolecular recognition site; other site
497965016224	PAS domain S-box; Region: sensory_box; TIGR00229
497965016225	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965016226	putative active site [active]
497965016227	heme pocket [chemical binding]; other site
497965016228	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965016229	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965016230	dimer interface [polypeptide binding]; other site
497965016231	phosphorylation site [posttranslational modification]
497965016232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965016233	ATP binding site [chemical binding]; other site
497965016234	Mg2+ binding site [ion binding]; other site
497965016235	G-X-G motif; other site
497965016236	Response regulator receiver domain; Region: Response_reg; pfam00072
497965016237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965016238	active site
497965016239	phosphorylation site [posttranslational modification]
497965016240	intermolecular recognition site; other site
497965016241	dimerization interface [polypeptide binding]; other site
497965016242	Response regulator receiver domain; Region: Response_reg; pfam00072
497965016243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965016244	active site
497965016245	phosphorylation site [posttranslational modification]
497965016246	intermolecular recognition site; other site
497965016247	dimerization interface [polypeptide binding]; other site
497965016248	Response regulator receiver domain; Region: Response_reg; pfam00072
497965016249	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965016250	active site
497965016251	phosphorylation site [posttranslational modification]
497965016252	intermolecular recognition site; other site
497965016253	PAS domain S-box; Region: sensory_box; TIGR00229
497965016254	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965016255	dimer interface [polypeptide binding]; other site
497965016256	phosphorylation site [posttranslational modification]
497965016257	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965016258	ATP binding site [chemical binding]; other site
497965016259	Mg2+ binding site [ion binding]; other site
497965016260	G-X-G motif; other site
497965016261	CHASE3 domain; Region: CHASE3; pfam05227
497965016262	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
497965016263	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965016264	putative active site [active]
497965016265	heme pocket [chemical binding]; other site
497965016266	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965016267	dimer interface [polypeptide binding]; other site
497965016268	phosphorylation site [posttranslational modification]
497965016269	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965016270	ATP binding site [chemical binding]; other site
497965016271	Mg2+ binding site [ion binding]; other site
497965016272	G-X-G motif; other site
497965016273	Cupin domain; Region: Cupin_2; pfam07883
497965016274	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965016275	Cna protein B-type domain; Region: Cna_B; pfam05738
497965016276	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
497965016277	active site
497965016278	zinc binding site [ion binding]; other site
497965016279	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965016280	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
497965016281	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
497965016282	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
497965016283	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
497965016284	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
497965016285	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
497965016286	NAD binding site [chemical binding]; other site
497965016287	homodimer interface [polypeptide binding]; other site
497965016288	active site
497965016289	substrate binding site [chemical binding]; other site
497965016290	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
497965016291	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
497965016292	active site
497965016293	hypothetical protein; Provisional; Region: PRK07208
497965016294	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965016295	UDP-galactopyranose mutase; Region: GLF; pfam03275
497965016296	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
497965016297	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
497965016298	Probable Catalytic site; other site
497965016299	metal-binding site
497965016300	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
497965016301	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965016302	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965016303	active site
497965016304	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
497965016305	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965016306	active site
497965016307	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497965016308	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965016309	active site
497965016310	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
497965016311	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
497965016312	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
497965016313	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
497965016314	Walker A/P-loop; other site
497965016315	ATP binding site [chemical binding]; other site
497965016316	Q-loop/lid; other site
497965016317	ABC transporter signature motif; other site
497965016318	Walker B; other site
497965016319	D-loop; other site
497965016320	H-loop/switch region; other site
497965016321	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
497965016322	putative carbohydrate binding site [chemical binding]; other site
497965016323	Predicted membrane protein [Function unknown]; Region: COG2246
497965016324	GtrA-like protein; Region: GtrA; pfam04138
497965016325	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497965016326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965016327	S-adenosylmethionine binding site [chemical binding]; other site
497965016328	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
497965016329	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
497965016330	Ligand binding site; other site
497965016331	Putative Catalytic site; other site
497965016332	DXD motif; other site
497965016333	Methyltransferase domain; Region: Methyltransf_24; pfam13578
497965016334	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497965016335	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965016336	S-adenosylmethionine binding site [chemical binding]; other site
497965016337	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
497965016338	Response regulator receiver domain; Region: Response_reg; pfam00072
497965016339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965016340	active site
497965016341	phosphorylation site [posttranslational modification]
497965016342	intermolecular recognition site; other site
497965016343	dimerization interface [polypeptide binding]; other site
497965016344	AAA ATPase domain; Region: AAA_16; pfam13191
497965016345	NACHT domain; Region: NACHT; pfam05729
497965016346	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965016347	structural tetrad; other site
497965016348	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965016349	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965016350	structural tetrad; other site
497965016351	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
497965016352	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965016353	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
497965016354	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
497965016355	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
497965016356	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
497965016357	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965016358	Coenzyme A binding pocket [chemical binding]; other site
497965016359	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
497965016360	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
497965016361	putative active site [active]
497965016362	putative metal binding site [ion binding]; other site
497965016363	Condensation domain; Region: Condensation; pfam00668
497965016364	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
497965016365	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
497965016366	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
497965016367	acyl-activating enzyme (AAE) consensus motif; other site
497965016368	AMP binding site [chemical binding]; other site
497965016369	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
497965016370	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
497965016371	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
497965016372	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
497965016373	Probable Catalytic site; other site
497965016374	metal-binding site
497965016375	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965016376	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
497965016377	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965016378	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965016379	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965016380	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965016381	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497965016382	Peptidase family M23; Region: Peptidase_M23; pfam01551
497965016383	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
497965016384	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
497965016385	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
497965016386	Walker A/P-loop; other site
497965016387	ATP binding site [chemical binding]; other site
497965016388	Q-loop/lid; other site
497965016389	ABC transporter signature motif; other site
497965016390	Walker B; other site
497965016391	D-loop; other site
497965016392	H-loop/switch region; other site
497965016393	DevC protein; Region: devC; TIGR01185
497965016394	FtsX-like permease family; Region: FtsX; pfam02687
497965016395	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
497965016396	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965016397	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965016398	Serine hydrolase; Region: Ser_hydrolase; cl17834
497965016399	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
497965016400	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
497965016401	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
497965016402	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
497965016403	dsDNA Poxvirus; Region: Poxvirus; cl17197
497965016404	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
497965016405	potential frameshift: common BLAST hit: gi|53804433|ref|YP_113701.1| polyketide synthase
497965016406	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
497965016407	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
497965016408	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
497965016409	putative NADP binding site [chemical binding]; other site
497965016410	active site
497965016411	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
497965016412	active site
497965016413	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
497965016414	3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050
497965016415	active site
497965016416	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
497965016417	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
497965016418	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
497965016419	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965016420	P-loop; other site
497965016421	Magnesium ion binding site [ion binding]; other site
497965016422	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965016423	Magnesium ion binding site [ion binding]; other site
497965016424	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
497965016425	O-succinylbenzoate synthase; Provisional; Region: PRK02714
497965016426	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
497965016427	active site
497965016428	Beta-propeller repeat; Region: SBBP; pfam06739
497965016429	MFS/sugar transport protein; Region: MFS_2; pfam13347
497965016430	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
497965016431	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
497965016432	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
497965016433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965016434	NAD(P) binding site [chemical binding]; other site
497965016435	active site
497965016436	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
497965016437	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
497965016438	active site
497965016439	Acyl transferase domain; Region: Acyl_transf_1; cl08282
497965016440	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
497965016441	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
497965016442	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
497965016443	active site
497965016444	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
497965016445	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
497965016446	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965016447	Enoylreductase; Region: PKS_ER; smart00829
497965016448	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
497965016449	NAD(P) binding site [chemical binding]; other site
497965016450	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
497965016451	KR domain; Region: KR; pfam08659
497965016452	putative NADP binding site [chemical binding]; other site
497965016453	active site
497965016454	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
497965016455	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
497965016456	acyl-CoA synthetase; Validated; Region: PRK05850
497965016457	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
497965016458	acyl-activating enzyme (AAE) consensus motif; other site
497965016459	active site
497965016460	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965016461	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
497965016462	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497965016463	HlyD family secretion protein; Region: HlyD_3; pfam13437
497965016464	DevC protein; Region: devC; TIGR01185
497965016465	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
497965016466	FtsX-like permease family; Region: FtsX; pfam02687
497965016467	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
497965016468	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
497965016469	Walker A/P-loop; other site
497965016470	ATP binding site [chemical binding]; other site
497965016471	Q-loop/lid; other site
497965016472	ABC transporter signature motif; other site
497965016473	Walker B; other site
497965016474	D-loop; other site
497965016475	H-loop/switch region; other site
497965016476	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
497965016477	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
497965016478	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
497965016479	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
497965016480	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
497965016481	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
497965016482	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
497965016483	U2 snRNP auxilliary factor, large subunit, splicing factor; Region: U2AF_lg; TIGR01642
497965016484	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
497965016485	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
497965016486	FAD binding domain; Region: FAD_binding_3; pfam01494
497965016487	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
497965016488	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
497965016489	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
497965016490	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
497965016491	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
497965016492	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
497965016493	dimer interface [polypeptide binding]; other site
497965016494	active site
497965016495	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
497965016496	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
497965016497	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
497965016498	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
497965016499	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
497965016500	choice-of-anchor B domain; Region: choice_anch_B; TIGR04312
497965016501	LVIVD repeat; Region: LVIVD; pfam08309
497965016502	LVIVD repeat; Region: LVIVD; pfam08309
497965016503	LVIVD repeat; Region: LVIVD; pfam08309
497965016504	LVIVD repeat; Region: LVIVD; pfam08309
497965016505	LVIVD repeat; Region: LVIVD; pfam08309
497965016506	LVIVD repeat; Region: LVIVD; pfam08309
497965016507	LVIVD repeat; Region: LVIVD; pfam08309
497965016508	LVIVD repeat; Region: LVIVD; pfam08309
497965016509	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
497965016510	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
497965016511	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
497965016512	NADP binding site [chemical binding]; other site
497965016513	active site
497965016514	putative substrate binding site [chemical binding]; other site
497965016515	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
497965016516	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016517	putative homodimer interface [polypeptide binding]; other site
497965016518	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
497965016519	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965016520	UDP-galactopyranose mutase; Region: GLF; pfam03275
497965016521	benzoate transport; Region: 2A0115; TIGR00895
497965016522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965016523	putative substrate translocation pore; other site
497965016524	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497965016525	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
497965016526	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
497965016527	active site
497965016528	Condensation domain; Region: Condensation; pfam00668
497965016529	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
497965016530	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
497965016531	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
497965016532	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
497965016533	acyl-CoA synthetase; Validated; Region: PRK05850
497965016534	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
497965016535	acyl-activating enzyme (AAE) consensus motif; other site
497965016536	active site
497965016537	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497965016538	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
497965016539	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
497965016540	active site
497965016541	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
497965016542	Cytochrome P450; Region: p450; cl12078
497965016543	CARDB; Region: CARDB; pfam07705
497965016544	Uncharacterized conserved protein [Function unknown]; Region: COG1572
497965016545	CARDB; Region: CARDB; pfam07705
497965016546	CARDB; Region: CARDB; pfam07705
497965016547	CARDB; Region: CARDB; pfam07705
497965016548	Uncharacterized conserved protein [Function unknown]; Region: COG1572
497965016549	CARDB; Region: CARDB; pfam07705
497965016550	CARDB; Region: CARDB; pfam07705
497965016551	CARDB; Region: CARDB; pfam07705
497965016552	CARDB; Region: CARDB; pfam07705
497965016553	CARDB; Region: CARDB; pfam07705
497965016554	CARDB; Region: CARDB; pfam07705
497965016555	CARDB; Region: CARDB; pfam07705
497965016556	CARDB; Region: CARDB; pfam07705
497965016557	CARDB; Region: CARDB; pfam07705
497965016558	CARDB; Region: CARDB; pfam07705
497965016559	CARDB; Region: CARDB; pfam07705
497965016560	CARDB; Region: CARDB; pfam07705
497965016561	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
497965016562	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965016563	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965016564	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965016565	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
497965016566	Uncharacterized conserved protein [Function unknown]; Region: COG3391
497965016567	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
497965016568	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
497965016569	active site
497965016570	substrate binding site [chemical binding]; other site
497965016571	Mg2+ binding site [ion binding]; other site
497965016572	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
497965016573	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
497965016574	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
497965016575	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
497965016576	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
497965016577	Calx-beta domain; Region: Calx-beta; pfam03160
497965016578	Calx-beta domain; Region: Calx-beta; pfam03160
497965016579	Calx-beta domain; Region: Calx-beta; pfam03160
497965016580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965016581	active site
497965016582	phosphorylation site [posttranslational modification]
497965016583	intermolecular recognition site; other site
497965016584	CHASE2 domain; Region: CHASE2; pfam05226
497965016585	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
497965016586	IncA protein; Region: IncA; pfam04156
497965016587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965016588	ATP binding site [chemical binding]; other site
497965016589	Mg2+ binding site [ion binding]; other site
497965016590	G-X-G motif; other site
497965016591	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497965016592	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965016593	salt bridge; other site
497965016594	non-specific DNA binding site [nucleotide binding]; other site
497965016595	sequence-specific DNA binding site [nucleotide binding]; other site
497965016596	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
497965016597	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
497965016598	Domain of unknown function (DUF305); Region: DUF305; pfam03713
497965016599	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
497965016600	HD domain; Region: HD_4; pfam13328
497965016601	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
497965016602	Triose-phosphate Transporter family; Region: TPT; pfam03151
497965016603	Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like4; cd07217
497965016604	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
497965016605	active site
497965016606	nucleophile elbow; other site
497965016607	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
497965016608	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
497965016609	active site
497965016610	substrate binding site [chemical binding]; other site
497965016611	Mg2+ binding site [ion binding]; other site
497965016612	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
497965016613	Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229
497965016614	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
497965016615	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
497965016616	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
497965016617	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
497965016618	Sulfatase; Region: Sulfatase; pfam00884
497965016619	Spumavirus gag protein; Region: Gag_spuma; pfam03276
497965016620	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
497965016621	Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865
497965016622	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
497965016623	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
497965016624	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
497965016625	Sulfate transporter family; Region: Sulfate_transp; pfam00916
497965016626	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
497965016627	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965016628	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965016629	ligand binding site [chemical binding]; other site
497965016630	flexible hinge region; other site
497965016631	SdpI/YhfL protein family; Region: SdpI; pfam13630
497965016632	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
497965016633	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497965016634	C-terminal domain interface [polypeptide binding]; other site
497965016635	GSH binding site (G-site) [chemical binding]; other site
497965016636	dimer interface [polypeptide binding]; other site
497965016637	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
497965016638	N-terminal domain interface [polypeptide binding]; other site
497965016639	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
497965016640	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
497965016641	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
497965016642	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
497965016643	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
497965016644	Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415
497965016645	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497965016646	active site
497965016647	DNA binding site [nucleotide binding]
497965016648	Int/Topo IB signature motif; other site
497965016649	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
497965016650	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965016651	putative substrate translocation pore; other site
497965016652	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965016653	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
497965016654	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
497965016655	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965016656	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
497965016657	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
497965016658	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497965016659	catalytic residue [active]
497965016660	Biofilm formation and stress response factor; Region: BsmA; pfam10014
497965016661	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965016662	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
497965016663	LVIVD repeat; Region: LVIVD; pfam08309
497965016664	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
497965016665	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
497965016666	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
497965016667	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
497965016668	active site
497965016669	dimer interface [polypeptide binding]; other site
497965016670	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
497965016671	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
497965016672	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
497965016673	generic binding surface II; other site
497965016674	generic binding surface I; other site
497965016675	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
497965016676	putative active site [active]
497965016677	putative catalytic site [active]
497965016678	putative Mg binding site IVb [ion binding]; other site
497965016679	putative phosphate binding site [ion binding]; other site
497965016680	putative DNA binding site [nucleotide binding]; other site
497965016681	putative Mg binding site IVa [ion binding]; other site
497965016682	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965016683	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
497965016684	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965016685	PAS fold; Region: PAS_3; pfam08447
497965016686	putative active site [active]
497965016687	heme pocket [chemical binding]; other site
497965016688	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965016689	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965016690	metal binding site [ion binding]; metal-binding site
497965016691	active site
497965016692	I-site; other site
497965016693	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497965016694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965016695	S-adenosylmethionine binding site [chemical binding]; other site
497965016696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
497965016697	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965016698	Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991
497965016699	active site
497965016700	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
497965016701	Uncharacterized conserved protein [Function unknown]; Region: COG3791
497965016702	Tic20-like protein; Region: Tic20; pfam09685
497965016703	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965016704	binding surface
497965016705	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965016706	TPR motif; other site
497965016707	TPR repeat; Region: TPR_11; pfam13414
497965016708	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497965016709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965016710	S-adenosylmethionine binding site [chemical binding]; other site
497965016711	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
497965016712	CheB methylesterase; Region: CheB_methylest; pfam01339
497965016713	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
497965016714	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016715	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
497965016716	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
497965016717	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
497965016718	acyl-activating enzyme (AAE) consensus motif; other site
497965016719	AMP binding site [chemical binding]; other site
497965016720	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
497965016721	Condensation domain; Region: Condensation; pfam00668
497965016722	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
497965016723	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
497965016724	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
497965016725	acyl-activating enzyme (AAE) consensus motif; other site
497965016726	AMP binding site [chemical binding]; other site
497965016727	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
497965016728	Condensation domain; Region: Condensation; pfam00668
497965016729	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
497965016730	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
497965016731	Condensation domain; Region: Condensation; pfam00668
497965016732	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
497965016733	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
497965016734	acyl-activating enzyme (AAE) consensus motif; other site
497965016735	AMP binding site [chemical binding]; other site
497965016736	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
497965016737	Condensation domain; Region: Condensation; pfam00668
497965016738	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
497965016739	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
497965016740	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
497965016741	acyl-activating enzyme (AAE) consensus motif; other site
497965016742	AMP binding site [chemical binding]; other site
497965016743	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
497965016744	Condensation domain; Region: Condensation; pfam00668
497965016745	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
497965016746	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
497965016747	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
497965016748	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
497965016749	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
497965016750	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
497965016751	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965016752	active site
497965016753	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965016754	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016755	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497965016756	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
497965016757	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497965016758	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
497965016759	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
497965016760	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
497965016761	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
497965016762	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497965016763	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
497965016764	Walker A/P-loop; other site
497965016765	ATP binding site [chemical binding]; other site
497965016766	Q-loop/lid; other site
497965016767	ABC transporter signature motif; other site
497965016768	Walker B; other site
497965016769	D-loop; other site
497965016770	H-loop/switch region; other site
497965016771	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965016772	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965016773	dimer interface [polypeptide binding]; other site
497965016774	phosphorylation site [posttranslational modification]
497965016775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965016776	ATP binding site [chemical binding]; other site
497965016777	Mg2+ binding site [ion binding]; other site
497965016778	G-X-G motif; other site
497965016779	Response regulator receiver domain; Region: Response_reg; pfam00072
497965016780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965016781	active site
497965016782	phosphorylation site [posttranslational modification]
497965016783	intermolecular recognition site; other site
497965016784	dimerization interface [polypeptide binding]; other site
497965016785	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965016786	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965016787	putative active site [active]
497965016788	heme pocket [chemical binding]; other site
497965016789	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965016790	putative active site [active]
497965016791	heme pocket [chemical binding]; other site
497965016792	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965016793	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965016794	dimer interface [polypeptide binding]; other site
497965016795	phosphorylation site [posttranslational modification]
497965016796	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965016797	ATP binding site [chemical binding]; other site
497965016798	Mg2+ binding site [ion binding]; other site
497965016799	G-X-G motif; other site
497965016800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965016801	Response regulator receiver domain; Region: Response_reg; pfam00072
497965016802	active site
497965016803	phosphorylation site [posttranslational modification]
497965016804	intermolecular recognition site; other site
497965016805	dimerization interface [polypeptide binding]; other site
497965016806	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
497965016807	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
497965016808	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497965016809	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
497965016810	active site
497965016811	metal binding site [ion binding]; metal-binding site
497965016812	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
497965016813	Major royal jelly protein; Region: MRJP; pfam03022
497965016814	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
497965016815	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
497965016816	calcium mediated ligand binding site; other site
497965016817	intermolecular salt bridges; other site
497965016818	Family description; Region: VCBS; pfam13517
497965016819	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497965016820	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497965016821	ligand binding site [chemical binding]; other site
497965016822	flexible hinge region; other site
497965016823	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965016824	dimer interface [polypeptide binding]; other site
497965016825	phosphorylation site [posttranslational modification]
497965016826	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965016827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965016828	ATP binding site [chemical binding]; other site
497965016829	Mg2+ binding site [ion binding]; other site
497965016830	G-X-G motif; other site
497965016831	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497965016832	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965016833	active site
497965016834	phosphorylation site [posttranslational modification]
497965016835	intermolecular recognition site; other site
497965016836	dimerization interface [polypeptide binding]; other site
497965016837	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
497965016838	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
497965016839	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497965016840	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497965016841	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
497965016842	dimerization interface [polypeptide binding]; other site
497965016843	putative active cleft [active]
497965016844	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
497965016845	anti sigma factor interaction site; other site
497965016846	regulatory phosphorylation site [posttranslational modification]; other site
497965016847	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
497965016848	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
497965016849	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
497965016850	active site
497965016851	catalytic site [active]
497965016852	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
497965016853	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
497965016854	conserved cys residue [active]
497965016855	NB-ARC domain; Region: NB-ARC; pfam00931
497965016856	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965016857	structural tetrad; other site
497965016858	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965016859	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965016860	structural tetrad; other site
497965016861	WD40 repeats; Region: WD40; smart00320
497965016862	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
497965016863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965016864	S-adenosylmethionine binding site [chemical binding]; other site
497965016865	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
497965016866	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
497965016867	active site
497965016868	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
497965016869	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
497965016870	PYR/PP interface [polypeptide binding]; other site
497965016871	dimer interface [polypeptide binding]; other site
497965016872	TPP binding site [chemical binding]; other site
497965016873	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
497965016874	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
497965016875	TPP-binding site [chemical binding]; other site
497965016876	hypothetical protein; Region: PHA01623
497965016877	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
497965016878	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
497965016879	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
497965016880	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
497965016881	FG-GAP repeat; Region: FG-GAP; pfam01839
497965016882	Family description; Region: VCBS; pfam13517
497965016883	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
497965016884	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
497965016885	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
497965016886	EthD domain; Region: EthD; pfam07110
497965016887	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
497965016888	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
497965016889	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
497965016890	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497965016891	motif II; other site
497965016892	Ion channel; Region: Ion_trans_2; pfam07885
497965016893	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
497965016894	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309
497965016895	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
497965016896	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
497965016897	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497965016898	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
497965016899	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497965016900	Coenzyme A binding pocket [chemical binding]; other site
497965016901	Ectoine synthase; Region: Ectoine_synth; pfam06339
497965016902	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497965016903	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
497965016904	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
497965016905	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
497965016906	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
497965016907	active site
497965016908	Riboflavin kinase; Region: Flavokinase; cl03312
497965016909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497965016910	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497965016911	putative substrate translocation pore; other site
497965016912	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497965016913	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497965016914	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
497965016915	homotrimer interaction site [polypeptide binding]; other site
497965016916	putative active site [active]
497965016917	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
497965016918	active site
497965016919	catalytic triad [active]
497965016920	oxyanion hole [active]
497965016921	Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669
497965016922	oligomer interface [polypeptide binding]; other site
497965016923	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965016924	RHS Repeat; Region: RHS_repeat; cl11982
497965016925	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
497965016926	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
497965016927	active site
497965016928	substrate binding site [chemical binding]; other site
497965016929	Mg2+ binding site [ion binding]; other site
497965016930	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
497965016931	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
497965016932	PKD domain; Region: PKD; pfam00801
497965016933	FOG: PKD repeat [General function prediction only]; Region: COG3291
497965016934	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
497965016935	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
497965016936	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
497965016937	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
497965016938	FOG: PKD repeat [General function prediction only]; Region: COG3291
497965016939	Calx-beta domain; Region: Calx-beta; pfam03160
497965016940	Calx-beta domain; Region: Calx-beta; pfam03160
497965016941	Calx-beta domain; Region: Calx-beta; pfam03160
497965016942	CARDB; Region: CARDB; pfam07705
497965016943	CARDB; Region: CARDB; pfam07705
497965016944	CARDB; Region: CARDB; pfam07705
497965016945	CARDB; Region: CARDB; pfam07705
497965016946	CARDB; Region: CARDB; pfam07705
497965016947	CARDB; Region: CARDB; pfam07705
497965016948	CARDB; Region: CARDB; pfam07705
497965016949	CARDB; Region: CARDB; pfam07705
497965016950	CARDB; Region: CARDB; pfam07705
497965016951	CARDB; Region: CARDB; pfam07705
497965016952	CARDB; Region: CARDB; pfam07705
497965016953	CARDB; Region: CARDB; pfam07705
497965016954	CARDB; Region: CARDB; pfam07705
497965016955	CARDB; Region: CARDB; pfam07705
497965016956	CARDB; Region: CARDB; pfam07705
497965016957	CARDB; Region: CARDB; pfam07705
497965016958	CARDB; Region: CARDB; pfam07705
497965016959	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
497965016960	Bacterial Ig-like domain; Region: Big_5; pfam13205
497965016961	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965016962	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965016963	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965016964	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965016965	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
497965016966	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
497965016967	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965016968	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965016969	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965016970	PAS domain; Region: PAS_9; pfam13426
497965016971	putative active site [active]
497965016972	heme pocket [chemical binding]; other site
497965016973	PAS fold; Region: PAS_3; pfam08447
497965016974	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965016975	heme pocket [chemical binding]; other site
497965016976	putative active site [active]
497965016977	PAS domain S-box; Region: sensory_box; TIGR00229
497965016978	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965016979	putative active site [active]
497965016980	heme pocket [chemical binding]; other site
497965016981	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965016982	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965016983	putative active site [active]
497965016984	heme pocket [chemical binding]; other site
497965016985	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965016986	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965016987	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965016988	putative active site [active]
497965016989	heme pocket [chemical binding]; other site
497965016990	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965016991	dimer interface [polypeptide binding]; other site
497965016992	phosphorylation site [posttranslational modification]
497965016993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965016994	ATP binding site [chemical binding]; other site
497965016995	Mg2+ binding site [ion binding]; other site
497965016996	G-X-G motif; other site
497965016997	Response regulator receiver domain; Region: Response_reg; pfam00072
497965016998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965016999	active site
497965017000	phosphorylation site [posttranslational modification]
497965017001	intermolecular recognition site; other site
497965017002	dimerization interface [polypeptide binding]; other site
497965017003	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965017004	putative active site [active]
497965017005	PAS fold; Region: PAS_3; pfam08447
497965017006	heme pocket [chemical binding]; other site
497965017007	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965017008	PAS fold; Region: PAS_4; pfam08448
497965017009	putative active site [active]
497965017010	heme pocket [chemical binding]; other site
497965017011	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965017012	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965017013	PAS domain S-box; Region: sensory_box; TIGR00229
497965017014	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965017015	putative active site [active]
497965017016	heme pocket [chemical binding]; other site
497965017017	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965017018	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965017019	putative active site [active]
497965017020	heme pocket [chemical binding]; other site
497965017021	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965017022	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497965017023	putative active site [active]
497965017024	heme pocket [chemical binding]; other site
497965017025	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965017026	putative active site [active]
497965017027	heme pocket [chemical binding]; other site
497965017028	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965017029	PAS fold; Region: PAS_3; pfam08447
497965017030	putative active site [active]
497965017031	heme pocket [chemical binding]; other site
497965017032	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497965017033	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497965017034	putative active site [active]
497965017035	heme pocket [chemical binding]; other site
497965017036	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965017037	dimer interface [polypeptide binding]; other site
497965017038	phosphorylation site [posttranslational modification]
497965017039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965017040	ATP binding site [chemical binding]; other site
497965017041	Mg2+ binding site [ion binding]; other site
497965017042	G-X-G motif; other site
497965017043	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965017044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965017045	active site
497965017046	phosphorylation site [posttranslational modification]
497965017047	intermolecular recognition site; other site
497965017048	dimerization interface [polypeptide binding]; other site
497965017049	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497965017050	DNA binding site [nucleotide binding]
497965017051	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497965017052	putative binding surface; other site
497965017053	active site
497965017054	Response regulator receiver domain; Region: Response_reg; pfam00072
497965017055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965017056	active site
497965017057	phosphorylation site [posttranslational modification]
497965017058	intermolecular recognition site; other site
497965017059	dimerization interface [polypeptide binding]; other site
497965017060	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497965017061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965017062	active site
497965017063	phosphorylation site [posttranslational modification]
497965017064	intermolecular recognition site; other site
497965017065	dimerization interface [polypeptide binding]; other site
497965017066	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497965017067	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497965017068	metal binding site [ion binding]; metal-binding site
497965017069	active site
497965017070	I-site; other site
497965017071	Response regulator receiver domain; Region: Response_reg; pfam00072
497965017072	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965017073	active site
497965017074	phosphorylation site [posttranslational modification]
497965017075	intermolecular recognition site; other site
497965017076	dimerization interface [polypeptide binding]; other site
497965017077	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965017078	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
497965017079	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
497965017080	active site
497965017081	Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198
497965017082	active site
497965017083	metal binding site [ion binding]; metal-binding site
497965017084	Ferritin-like; Region: Ferritin-like; pfam12902
497965017085	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
497965017086	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965017087	Ca2+ binding site [ion binding]; other site
497965017088	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965017089	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965017090	Ca2+ binding site [ion binding]; other site
497965017091	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965017092	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
497965017093	ligand binding surface [chemical binding]; other site
497965017094	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
497965017095	ligand binding surface [chemical binding]; other site
497965017096	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
497965017097	metal ion-dependent adhesion site (MIDAS); other site
497965017098	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965017099	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965017100	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
497965017101	RHS Repeat; Region: RHS_repeat; pfam05593
497965017102	RHS Repeat; Region: RHS_repeat; pfam05593
497965017103	RHS Repeat; Region: RHS_repeat; pfam05593
497965017104	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
497965017105	RHS Repeat; Region: RHS_repeat; pfam05593
497965017106	RHS Repeat; Region: RHS_repeat; cl11982
497965017107	RHS Repeat; Region: RHS_repeat; pfam05593
497965017108	RHS Repeat; Region: RHS_repeat; pfam05593
497965017109	RHS Repeat; Region: RHS_repeat; pfam05593
497965017110	RHS Repeat; Region: RHS_repeat; pfam05593
497965017111	RHS Repeat; Region: RHS_repeat; pfam05593
497965017112	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
497965017113	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
497965017114	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
497965017115	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
497965017116	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
497965017117	homodimer interface [polypeptide binding]; other site
497965017118	active site
497965017119	TDP-binding site; other site
497965017120	acceptor substrate-binding pocket; other site
497965017121	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
497965017122	MarR family; Region: MarR_2; pfam12802
497965017123	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
497965017124	polymerase nucleotide-binding site; other site
497965017125	DNA-binding residues [nucleotide binding]; DNA binding site
497965017126	nucleotide binding site [chemical binding]; other site
497965017127	primase nucleotide-binding site [nucleotide binding]; other site
497965017128	CHC2 zinc finger; Region: zf-CHC2; cl17510
497965017129	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
497965017130	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
497965017131	Part of AAA domain; Region: AAA_19; pfam13245
497965017132	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
497965017133	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
497965017134	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965017135	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497965017136	dimer interface [polypeptide binding]; other site
497965017137	phosphorylation site [posttranslational modification]
497965017138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965017139	ATP binding site [chemical binding]; other site
497965017140	Mg2+ binding site [ion binding]; other site
497965017141	G-X-G motif; other site
497965017142	Response regulator receiver domain; Region: Response_reg; pfam00072
497965017143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965017144	active site
497965017145	phosphorylation site [posttranslational modification]
497965017146	intermolecular recognition site; other site
497965017147	dimerization interface [polypeptide binding]; other site
497965017148	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497965017149	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497965017150	ATP binding site [chemical binding]; other site
497965017151	Mg2+ binding site [ion binding]; other site
497965017152	G-X-G motif; other site
497965017153	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965017154	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965017155	active site
497965017156	phosphorylation site [posttranslational modification]
497965017157	intermolecular recognition site; other site
497965017158	dimerization interface [polypeptide binding]; other site
497965017159	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965017160	dimerization interface [polypeptide binding]; other site
497965017161	DNA binding residues [nucleotide binding]
497965017162	PIN domain; Region: PIN_3; pfam13470
497965017163	DNA polymerase III subunit beta; Validated; Region: PRK05643
497965017164	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
497965017165	putative DNA binding surface [nucleotide binding]; other site
497965017166	dimer interface [polypeptide binding]; other site
497965017167	beta-clamp/clamp loader binding surface; other site
497965017168	beta-clamp/translesion DNA polymerase binding surface; other site
497965017169	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497965017170	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965017171	active site
497965017172	phosphorylation site [posttranslational modification]
497965017173	intermolecular recognition site; other site
497965017174	dimerization interface [polypeptide binding]; other site
497965017175	HPP family; Region: HPP; pfam04982
497965017176	Predicted membrane protein [Function unknown]; Region: COG4325
497965017177	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
497965017178	BON domain; Region: BON; pfam04972
497965017179	Ion transport protein; Region: Ion_trans; pfam00520
497965017180	Ion channel; Region: Ion_trans_2; pfam07885
497965017181	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
497965017182	dimerization interface [polypeptide binding]; other site
497965017183	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497965017184	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497965017185	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017186	binding surface
497965017187	TPR motif; other site
497965017188	Predicted membrane protein [Function unknown]; Region: COG1808
497965017189	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
497965017190	EamA-like transporter family; Region: EamA; cl17759
497965017191	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
497965017192	Cupin domain; Region: Cupin_2; pfam07883
497965017193	oxidoreductase; Provisional; Region: PRK06128
497965017194	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
497965017195	NAD binding site [chemical binding]; other site
497965017196	metal binding site [ion binding]; metal-binding site
497965017197	active site
497965017198	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
497965017199	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
497965017200	NAD binding site [chemical binding]; other site
497965017201	catalytic Zn binding site [ion binding]; other site
497965017202	structural Zn binding site [ion binding]; other site
497965017203	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
497965017204	Strictosidine synthase; Region: Str_synth; pfam03088
497965017205	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
497965017206	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
497965017207	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
497965017208	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
497965017209	Domain interface; other site
497965017210	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
497965017211	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
497965017212	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497965017213	glucose-1-dehydrogenase; Provisional; Region: PRK08936
497965017214	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
497965017215	NAD binding site [chemical binding]; other site
497965017216	homodimer interface [polypeptide binding]; other site
497965017217	active site
497965017218	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497965017219	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
497965017220	active site
497965017221	metal binding site [ion binding]; metal-binding site
497965017222	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
497965017223	Prophage antirepressor [Transcription]; Region: COG3617
497965017224	BRO family, N-terminal domain; Region: Bro-N; smart01040
497965017225	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497965017226	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965017227	non-specific DNA binding site [nucleotide binding]; other site
497965017228	salt bridge; other site
497965017229	sequence-specific DNA binding site [nucleotide binding]; other site
497965017230	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965017231	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965017232	active site
497965017233	Homeodomain-like domain; Region: HTH_23; pfam13384
497965017234	Winged helix-turn helix; Region: HTH_29; pfam13551
497965017235	Winged helix-turn helix; Region: HTH_33; pfam13592
497965017236	DDE superfamily endonuclease; Region: DDE_3; pfam13358
497965017237	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
497965017238	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965017239	HSP70 interaction site [polypeptide binding]; other site
497965017240	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
497965017241	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965017242	Probable transposase; Region: OrfB_IS605; pfam01385
497965017243	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965017244	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497965017245	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965017246	non-specific DNA binding site [nucleotide binding]; other site
497965017247	salt bridge; other site
497965017248	sequence-specific DNA binding site [nucleotide binding]; other site
497965017249	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
497965017250	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965017251	active site
497965017252	ATP binding site [chemical binding]; other site
497965017253	substrate binding site [chemical binding]; other site
497965017254	activation loop (A-loop); other site
497965017255	AAA ATPase domain; Region: AAA_16; pfam13191
497965017256	Predicted ATPase [General function prediction only]; Region: COG3899
497965017257	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
497965017258	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497965017259	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
497965017260	YcaO-like family; Region: YcaO; pfam02624
497965017261	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
497965017262	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
497965017263	putative FMN binding site [chemical binding]; other site
497965017264	NADPH bind site [chemical binding]; other site
497965017265	Amidohydrolase; Region: Amidohydro_2; pfam04909
497965017266	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
497965017267	YcaO-like family; Region: YcaO; pfam02624
497965017268	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
497965017269	Homeodomain-like domain; Region: HTH_23; pfam13384
497965017270	Winged helix-turn helix; Region: HTH_29; pfam13551
497965017271	Winged helix-turn helix; Region: HTH_33; pfam13592
497965017272	DDE superfamily endonuclease; Region: DDE_3; pfam13358
497965017273	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
497965017274	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
497965017275	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
497965017276	putative active site [active]
497965017277	DDE superfamily endonuclease; Region: DDE_5; cl17874
497965017278	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
497965017279	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
497965017280	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
497965017281	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
497965017282	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
497965017283	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
497965017284	CRISPR-associated protein; Region: DUF3692; pfam12469
497965017285	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
497965017286	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
497965017287	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
497965017288	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
497965017289	putative active site [active]
497965017290	putative NTP binding site [chemical binding]; other site
497965017291	putative nucleic acid binding site [nucleotide binding]; other site
497965017292	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
497965017293	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017294	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017295	binding surface
497965017296	TPR motif; other site
497965017297	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017298	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017299	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017300	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017301	binding surface
497965017302	TPR motif; other site
497965017303	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017304	AAA ATPase domain; Region: AAA_16; pfam13191
497965017305	Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693
497965017306	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965017307	HEPN domain; Region: HEPN; cl00824
497965017308	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965017309	non-specific DNA binding site [nucleotide binding]; other site
497965017310	salt bridge; other site
497965017311	sequence-specific DNA binding site [nucleotide binding]; other site
497965017312	AntA/AntB antirepressor; Region: AntA; cl01430
497965017313	Homeodomain-like domain; Region: HTH_23; pfam13384
497965017314	Winged helix-turn helix; Region: HTH_29; pfam13551
497965017315	Winged helix-turn helix; Region: HTH_33; pfam13592
497965017316	DDE superfamily endonuclease; Region: DDE_3; pfam13358
497965017317	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
497965017318	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965017319	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
497965017320	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
497965017321	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497965017322	active site
497965017323	catalytic residues [active]
497965017324	DNA binding site [nucleotide binding]
497965017325	Int/Topo IB signature motif; other site
497965017326	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
497965017327	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
497965017328	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
497965017329	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965017330	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
497965017331	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497965017332	DNA binding residues [nucleotide binding]
497965017333	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
497965017334	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
497965017335	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965017336	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
497965017337	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
497965017338	oligomeric interface; other site
497965017339	putative active site [active]
497965017340	homodimer interface [polypeptide binding]; other site
497965017341	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
497965017342	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
497965017343	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
497965017344	putative active site [active]
497965017345	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
497965017346	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
497965017347	non-specific DNA binding site [nucleotide binding]; other site
497965017348	salt bridge; other site
497965017349	sequence-specific DNA binding site [nucleotide binding]; other site
497965017350	Bacterial TniB protein; Region: TniB; pfam05621
497965017351	AAA domain; Region: AAA_22; pfam13401
497965017352	Homeodomain-like domain; Region: HTH_23; pfam13384
497965017353	Winged helix-turn helix; Region: HTH_29; pfam13551
497965017354	Integrase core domain; Region: rve; pfam00665
497965017355	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
497965017356	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
497965017357	DDE superfamily endonuclease; Region: DDE_5; cl17874
497965017358	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
497965017359	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
497965017360	Toprim-like; Region: Toprim_2; pfam13155
497965017361	active site
497965017362	metal binding site [ion binding]; metal-binding site
497965017363	D5 N terminal like; Region: D5_N; pfam08706
497965017364	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
497965017365	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
497965017366	metal ion-dependent adhesion site (MIDAS); other site
497965017367	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965017368	Ca2+ binding site [ion binding]; other site
497965017369	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965017370	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965017371	Ca2+ binding site [ion binding]; other site
497965017372	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965017373	von Willebrand factor type D domain; Region: VWD; cl02516
497965017374	Calx-beta domain; Region: Calx-beta; pfam03160
497965017375	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965017376	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
497965017377	putative active site [active]
497965017378	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965017379	Ca2+ binding site [ion binding]; other site
497965017380	CARDB; Region: CARDB; pfam07705
497965017381	CARDB; Region: CARDB; pfam07705
497965017382	CARDB; Region: CARDB; pfam07705
497965017383	CARDB; Region: CARDB; pfam07705
497965017384	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
497965017385	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
497965017386	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965017387	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965017388	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965017389	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965017390	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
497965017391	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
497965017392	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
497965017393	active site
497965017394	substrate binding site [chemical binding]; other site
497965017395	Mg2+ binding site [ion binding]; other site
497965017396	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
497965017397	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965017398	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
497965017399	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
497965017400	putative catalytic site [active]
497965017401	putative metal binding site [ion binding]; other site
497965017402	putative phosphate binding site [ion binding]; other site
497965017403	Endonuclease I; Region: Endonuclease_1; cl01003
497965017404	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
497965017405	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
497965017406	Surface antigen; Region: Bac_surface_Ag; pfam01103
497965017407	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
497965017408	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
497965017409	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
497965017410	dinuclear metal binding motif [ion binding]; other site
497965017411	CHAT domain; Region: CHAT; cl17868
497965017412	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
497965017413	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
497965017414	CHASE2 domain; Region: CHASE2; pfam05226
497965017415	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965017416	non-specific DNA binding site [nucleotide binding]; other site
497965017417	salt bridge; other site
497965017418	sequence-specific DNA binding site [nucleotide binding]; other site
497965017419	NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family; Region: eNOPS_SF; cl06904
497965017420	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497965017421	active site
497965017422	DNA binding site [nucleotide binding]
497965017423	Int/Topo IB signature motif; other site
497965017424	ParB-like nuclease domain; Region: ParBc; pfam02195
497965017425	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
497965017426	active site
497965017427	putative DNA-binding cleft [nucleotide binding]; other site
497965017428	dimer interface [polypeptide binding]; other site
497965017429	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
497965017430	AAA domain; Region: AAA_25; pfam13481
497965017431	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965017432	ATP binding site [chemical binding]; other site
497965017433	Walker B motif; other site
497965017434	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965017435	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965017436	DNA binding residues [nucleotide binding]
497965017437	dimerization interface [polypeptide binding]; other site
497965017438	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497965017439	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497965017440	DNA binding residues [nucleotide binding]
497965017441	dimerization interface [polypeptide binding]; other site
497965017442	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
497965017443	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497965017444	AAA-like domain; Region: AAA_10; pfam12846
497965017445	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
497965017446	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
497965017447	AAA-like domain; Region: AAA_10; pfam12846
497965017448	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
497965017449	Mg binding site [ion binding]; other site
497965017450	nucleotide binding site [chemical binding]; other site
497965017451	putative protofilament interface [polypeptide binding]; other site
497965017452	ATPase MipZ; Region: MipZ; pfam09140
497965017453	Ycf46; Provisional; Region: ycf46; CHL00195
497965017454	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
497965017455	DEAD-like helicases superfamily; Region: DEXDc; smart00487
497965017456	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497965017457	ATP binding site [chemical binding]; other site
497965017458	putative Mg++ binding site [ion binding]; other site
497965017459	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
497965017460	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497965017461	nucleotide binding region [chemical binding]; other site
497965017462	ATP-binding site [chemical binding]; other site
497965017463	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
497965017464	putative active site [active]
497965017465	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
497965017466	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
497965017467	dimer interface [polypeptide binding]; other site
497965017468	ssDNA binding site [nucleotide binding]; other site
497965017469	tetramer (dimer of dimers) interface [polypeptide binding]; other site
497965017470	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
497965017471	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
497965017472	putative active site [active]
497965017473	putative NTP binding site [chemical binding]; other site
497965017474	putative nucleic acid binding site [nucleotide binding]; other site
497965017475	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
497965017476	DNA polymerase III subunit delta'; Validated; Region: PRK07399
497965017477	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
497965017478	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
497965017479	DNA polymerase III subunit delta; Validated; Region: PRK07452
497965017480	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
497965017481	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497965017482	Walker A motif; other site
497965017483	ATP binding site [chemical binding]; other site
497965017484	Walker B motif; other site
497965017485	arginine finger; other site
497965017486	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
497965017487	DNA polymerase III subunit beta; Validated; Region: PRK05643
497965017488	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
497965017489	putative DNA binding surface [nucleotide binding]; other site
497965017490	dimer interface [polypeptide binding]; other site
497965017491	beta-clamp/clamp loader binding surface; other site
497965017492	beta-clamp/translesion DNA polymerase binding surface; other site
497965017493	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
497965017494	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
497965017495	active site
497965017496	GIY-YIG motif/motif A; other site
497965017497	catalytic site [active]
497965017498	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
497965017499	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
497965017500	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
497965017501	RRXRR protein; Region: RRXRR; pfam14239
497965017502	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965017503	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965017504	active site
497965017505	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
497965017506	Probable transposase; Region: OrfB_IS605; pfam01385
497965017507	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
497965017508	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
497965017509	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
497965017510	Transposase; Region: DDE_Tnp_ISL3; pfam01610
497965017511	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
497965017512	ParB-like nuclease domain; Region: ParBc; pfam02195
497965017513	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
497965017514	Helix-turn-helix domain; Region: HTH_28; pfam13518
497965017515	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
497965017516	ATP binding site [chemical binding]; other site
497965017517	substrate interface [chemical binding]; other site
497965017518	PRTRC system protein A; Region: PRTRC_A; TIGR03735
497965017519	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
497965017520	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
497965017521	Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020
497965017522	TPR repeat; Region: TPR_11; pfam13414
497965017523	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017524	binding surface
497965017525	TPR motif; other site
497965017526	TPR repeat; Region: TPR_11; pfam13414
497965017527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017528	binding surface
497965017529	TPR motif; other site
497965017530	TPR repeat; Region: TPR_11; pfam13414
497965017531	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017532	binding surface
497965017533	TPR motif; other site
497965017534	TPR repeat; Region: TPR_11; pfam13414
497965017535	TPR repeat; Region: TPR_11; pfam13414
497965017536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017537	TPR motif; other site
497965017538	binding surface
497965017539	TPR repeat; Region: TPR_11; pfam13414
497965017540	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017541	binding surface
497965017542	TPR motif; other site
497965017543	TPR repeat; Region: TPR_11; pfam13414
497965017544	Tetratricopeptide repeat; Region: TPR_9; pfam13371
497965017545	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965017546	HSP70 interaction site [polypeptide binding]; other site
497965017547	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
497965017548	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965017549	Transposase [DNA replication, recombination, and repair]; Region: COG5433
497965017550	Transposase [DNA replication, recombination, and repair]; Region: COG5433
497965017551	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
497965017552	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
497965017553	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965017554	Ca2+ binding site [ion binding]; other site
497965017555	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965017556	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965017557	Ca2+ binding site [ion binding]; other site
497965017558	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
497965017559	Ca2+ binding site [ion binding]; other site
497965017560	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965017561	structural tetrad; other site
497965017562	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965017563	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965017564	structural tetrad; other site
497965017565	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965017566	structural tetrad; other site
497965017567	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
497965017568	ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346
497965017569	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497965017570	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
497965017571	Walker A motif; other site
497965017572	ATP binding site [chemical binding]; other site
497965017573	Walker B motif; other site
497965017574	AAA ATPase domain; Region: AAA_16; pfam13191
497965017575	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017576	binding surface
497965017577	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017578	TPR motif; other site
497965017579	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017580	binding surface
497965017581	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017582	TPR motif; other site
497965017583	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017584	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017585	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
497965017586	G1 box; other site
497965017587	GTP/Mg2+ binding site [chemical binding]; other site
497965017588	G2 box; other site
497965017589	Switch I region; other site
497965017590	G3 box; other site
497965017591	Switch II region; other site
497965017592	G4 box; other site
497965017593	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965017594	Walker A/P-loop; other site
497965017595	ATP binding site [chemical binding]; other site
497965017596	Q-loop/lid; other site
497965017597	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
497965017598	metal ion-dependent adhesion site (MIDAS); other site
497965017599	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
497965017600	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
497965017601	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
497965017602	metal ion-dependent adhesion site (MIDAS); other site
497965017603	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
497965017604	metal ion-dependent adhesion site (MIDAS); other site
497965017605	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
497965017606	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965017607	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965017608	phosphopeptide binding site; other site
497965017609	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
497965017610	Protein phosphatase 2C; Region: PP2C; pfam00481
497965017611	active site
497965017612	Protein kinase domain; Region: Pkinase; pfam00069
497965017613	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965017614	active site
497965017615	ATP binding site [chemical binding]; other site
497965017616	substrate binding site [chemical binding]; other site
497965017617	activation loop (A-loop); other site
497965017618	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497965017619	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497965017620	phosphopeptide binding site; other site
497965017621	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965017622	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965017623	active site
497965017624	ATP binding site [chemical binding]; other site
497965017625	substrate binding site [chemical binding]; other site
497965017626	activation loop (A-loop); other site
497965017627	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017628	binding surface
497965017629	Tetratricopeptide repeat; Region: TPR_16; pfam13432
497965017630	TPR motif; other site
497965017631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017632	binding surface
497965017633	TPR motif; other site
497965017634	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017635	Homeodomain-like domain; Region: HTH_23; pfam13384
497965017636	Winged helix-turn helix; Region: HTH_29; pfam13551
497965017637	Winged helix-turn helix; Region: HTH_33; pfam13592
497965017638	DDE superfamily endonuclease; Region: DDE_3; pfam13358
497965017639	Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693
497965017640	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965017641	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
497965017642	CHASE2 domain; Region: CHASE2; pfam05226
497965017643	AntA/AntB antirepressor; Region: AntA; cl01430
497965017644	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965017645	non-specific DNA binding site [nucleotide binding]; other site
497965017646	salt bridge; other site
497965017647	sequence-specific DNA binding site [nucleotide binding]; other site
497965017648	AAA ATPase domain; Region: AAA_16; pfam13191
497965017649	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017650	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017651	binding surface
497965017652	TPR motif; other site
497965017653	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017654	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017655	Tetratricopeptide repeat; Region: TPR_12; pfam13424
497965017656	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017657	binding surface
497965017658	TPR motif; other site
497965017659	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
497965017660	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
497965017661	putative active site [active]
497965017662	putative NTP binding site [chemical binding]; other site
497965017663	putative nucleic acid binding site [nucleotide binding]; other site
497965017664	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
497965017665	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
497965017666	TIR domain; Region: TIR_2; pfam13676
497965017667	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
497965017668	CRISPR-associated protein; Region: DUF3692; pfam12469
497965017669	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
497965017670	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
497965017671	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
497965017672	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
497965017673	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
497965017674	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
497965017675	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
497965017676	active site
497965017677	phosphorylation site [posttranslational modification]
497965017678	intermolecular recognition site; other site
497965017679	dimerization interface [polypeptide binding]; other site
497965017680	Winged helix-turn helix; Region: HTH_29; pfam13551
497965017681	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
497965017682	DNA binding residues [nucleotide binding]
497965017683	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
497965017684	AAA-like domain; Region: AAA_10; pfam12846
497965017685	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
497965017686	Domain of unknown function DUF87; Region: DUF87; pfam01935
497965017687	AAA-like domain; Region: AAA_10; pfam12846
497965017688	TrwC relaxase; Region: TrwC; pfam08751
497965017689	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
497965017690	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
497965017691	Mg binding site [ion binding]; other site
497965017692	nucleotide binding site [chemical binding]; other site
497965017693	putative protofilament interface [polypeptide binding]; other site
497965017694	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
497965017695	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
497965017696	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
497965017697	putative active site [active]
497965017698	putative NTP binding site [chemical binding]; other site
497965017699	putative nucleic acid binding site [nucleotide binding]; other site
497965017700	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
497965017701	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
497965017702	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
497965017703	active site
497965017704	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
497965017705	Catalytic domain of Protein Kinases; Region: PKc; cd00180
497965017706	active site
497965017707	ATP binding site [chemical binding]; other site
497965017708	substrate binding site [chemical binding]; other site
497965017709	activation loop (A-loop); other site
497965017710	KTSC domain; Region: KTSC; pfam13619
497965017711	DdrB-like protein; Region: DdrB; pfam12747
497965017712	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
497965017713	Domain of unknown function (DUF955); Region: DUF955; pfam06114
497965017714	TniQ; Region: TniQ; pfam06527
497965017715	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09688
497965017716	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
497965017717	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
497965017718	AAA ATPase domain; Region: AAA_16; pfam13191
497965017719	AAA domain; Region: AAA_22; pfam13401
497965017720	MOSC domain; Region: MOSC; pfam03473
497965017721	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
497965017722	active site
497965017723	DNA binding site [nucleotide binding]
497965017724	ParB-like nuclease domain; Region: ParBc; pfam02195
497965017725	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
497965017726	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965017727	P-loop; other site
497965017728	Magnesium ion binding site [ion binding]; other site
497965017729	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497965017730	Magnesium ion binding site [ion binding]; other site
497965017731	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497965017732	HSP70 interaction site [polypeptide binding]; other site
497965017733	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
497965017734	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
497965017735	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
497965017736	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
497965017737	Domain of unknown function DUF29; Region: DUF29; pfam01724
497965017738	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
497965017739	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
497965017740	Catalytic site; other site
497965017741	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
497965017742	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
497965017743	Uncharacterized conserved protein [Function unknown]; Region: COG3791
497965017744	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
497965017745	Leucine carboxyl methyltransferase; Region: LCM; cl01306
497965017746	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
497965017747	active site
497965017748	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
497965017749	Ligand Binding Site [chemical binding]; other site
497965017750	Molecular Tunnel; other site
497965017751	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
497965017752	active site
497965017753	metal binding site [ion binding]; metal-binding site
497965017754	diaminopimelate decarboxylase; Region: lysA; TIGR01048
497965017755	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
497965017756	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
497965017757	catalytic residue [active]
497965017758	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
497965017759	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
497965017760	Ligand Binding Site [chemical binding]; other site
497965017761	Molecular Tunnel; other site
497965017762	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965017763	S-adenosylmethionine binding site [chemical binding]; other site
497965017764	Uncharacterized conserved protein [Function unknown]; Region: COG4278
497965017765	TIGR04222 domain; Region: near_uncomplex
497965017766	D5 N terminal like; Region: D5_N; pfam08706
497965017767	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
497965017768	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
497965017769	tegument protein UL21; Provisional; Region: PHA03348
497965017770	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
497965017771	active site
497965017772	NTP binding site [chemical binding]; other site
497965017773	metal binding triad [ion binding]; metal-binding site
497965017774	antibiotic binding site [chemical binding]; other site
497965017775	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
497965017776	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965017777	NAD(P) binding site [chemical binding]; other site
497965017778	active site
497965017779	Transposase [DNA replication, recombination, and repair]; Region: COG5421
497965017780	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
497965017781	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965017782	Walker A/P-loop; other site
497965017783	ATP binding site [chemical binding]; other site
497965017784	Q-loop/lid; other site
497965017785	Integrase core domain; Region: rve; pfam00665
497965017786	multiple promoter invertase; Provisional; Region: mpi; PRK13413
497965017787	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
497965017788	catalytic residues [active]
497965017789	catalytic nucleophile [active]
497965017790	Presynaptic Site I dimer interface [polypeptide binding]; other site
497965017791	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
497965017792	Synaptic Flat tetramer interface [polypeptide binding]; other site
497965017793	Synaptic Site I dimer interface [polypeptide binding]; other site
497965017794	DNA binding site [nucleotide binding]
497965017795	Helix-turn-helix domain; Region: HTH_28; pfam13518
497965017796	Protein of unknown function (DUF972); Region: DUF972; pfam06156
497965017797	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
497965017798	Transposase; Region: DDE_Tnp_ISL3; pfam01610
497965017799	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
497965017800	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
497965017801	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
497965017802	2-oxoglutarate dehydrogenase E2 component; Region: PLN02226
497965017803	Ras GTPase Activating Domain; Region: RasGAP; cl02569
497965017804	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
497965017805	putative FMN binding site [chemical binding]; other site
497965017806	NADPH bind site [chemical binding]; other site
497965017807	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
497965017808	YcaO-like family; Region: YcaO; pfam02624
497965017809	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
497965017810	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
497965017811	putative active site [active]
497965017812	putative catalytic triad [active]
497965017813	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
497965017814	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965017815	S-adenosylmethionine binding site [chemical binding]; other site
497965017816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497965017817	S-adenosylmethionine binding site [chemical binding]; other site
497965017818	cyanobactin biosynthesis protein, PatB/AcyB/McaB family; Region: patB_acyB_mcaB; TIGR04220
497965017819	Integrase core domain; Region: rve; pfam00665
497965017820	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
497965017821	Bacterial TniB protein; Region: TniB; pfam05621
497965017822	AAA domain; Region: AAA_22; pfam13401
497965017823	TniQ; Region: TniQ; pfam06527
497965017824	D5 N terminal like; Region: D5_N; smart00885
497965017825	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
497965017826	MAC/Perforin domain; Region: MACPF; cl02616
497965017827	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965017828	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
497965017829	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
497965017830	Uncharacterized conserved protein [Function unknown]; Region: COG0585
497965017831	active site
497965017832	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497965017833	catalytic core [active]
497965017834	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
497965017835	active site
497965017836	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497965017837	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
497965017838	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
497965017839	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
497965017840	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
497965017841	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965017842	Walker A/P-loop; other site
497965017843	ATP binding site [chemical binding]; other site
497965017844	Q-loop/lid; other site
497965017845	ABC transporter signature motif; other site
497965017846	Walker B; other site
497965017847	D-loop; other site
497965017848	H-loop/switch region; other site
497965017849	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
497965017850	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
497965017851	Homeodomain-like domain; Region: HTH_23; pfam13384
497965017852	Winged helix-turn helix; Region: HTH_29; pfam13551
497965017853	Homeodomain-like domain; Region: HTH_32; pfam13565
497965017854	DDE superfamily endonuclease; Region: DDE_3; pfam13358
497965017855	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
497965017856	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497965017857	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497965017858	sequence-specific DNA binding site [nucleotide binding]; other site
497965017859	salt bridge; other site
497965017860	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497965017861	NACHT domain; Region: NACHT; pfam05729
497965017862	Walker A/P-loop; other site
497965017863	ATP binding site [chemical binding]; other site
497965017864	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497965017865	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497965017866	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
497965017867	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
497965017868	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
497965017869	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497965017870	NAD(P) binding site [chemical binding]; other site
497965017871	active site
497965017872	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
497965017873	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
497965017874	Uncharacterized conserved protein [Function unknown]; Region: COG1262
497965017875	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
497965017876	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
497965017877	GIY-YIG motif/motif A; other site
497965017878	active site
497965017879	catalytic site [active]
497965017880	metal binding site [ion binding]; metal-binding site
497965017881	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
497965017882	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
497965017883	Catalytic site; other site
497965017884	Excalibur calcium-binding domain; Region: Excalibur; cl05460
497965017885	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497965017886	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
497965017887	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497965017888	binding surface
497965017889	TPR motif; other site
497965017890	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
497965017891	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
497965017892	GUN4-like; Region: GUN4; pfam05419
497965017893	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
497965017894	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497965017895	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497965017896	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
497965017897	ParB-like nuclease domain; Region: ParBc; pfam02195
497965017898	DNA-sulfur modification-associated; Region: DndB; cl17621
497965017899	KTSC domain; Region: KTSC; pfam13619
497965017900	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
497965017901	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
497965017902	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
497965017903	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
497965017904	Probable Catalytic site; other site
497965017905	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965017906	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
497965017907	KTSC domain; Region: KTSC; pfam13619
497965017908	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
497965017909	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
497965017910	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
497965017911	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
497965017912	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
497965017913	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965017914	structural tetrad; other site
497965017915	FOG: WD40 repeat [General function prediction only]; Region: COG2319
497965017916	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
497965017917	structural tetrad; other site
497965017918	WD40 repeats; Region: WD40; smart00320
497965017919	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
497965017920	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497965017921	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
497965017922	Uncharacterized conserved protein; Region: KxDL; pfam10241
497965017923	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
497965017924	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497965017925	active site
497965017926	DNA binding site [nucleotide binding]
497965017927	Int/Topo IB signature motif; other site
497965017928	large terminase protein; Provisional; Region: 17; PHA02533
497965017929	Terminase-like family; Region: Terminase_6; pfam03237