-- dump date 20140619_054919 -- class Genbank::misc_feature -- table misc_feature_note -- id note 41431000001 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 41431000002 Caspase domain; Region: Peptidase_C14; pfam00656 41431000003 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 41431000004 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431000005 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431000006 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 41431000007 DNA binding residues [nucleotide binding] 41431000008 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 41431000009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 41431000010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 41431000011 Homeodomain-like domain; Region: HTH_23; pfam13384 41431000012 Winged helix-turn helix; Region: HTH_29; pfam13551 41431000013 Homeodomain-like domain; Region: HTH_32; pfam13565 41431000014 DDE superfamily endonuclease; Region: DDE_3; pfam13358 41431000015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 41431000016 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 41431000017 active site 41431000018 DNA binding site [nucleotide binding] 41431000019 Int/Topo IB signature motif; other site 41431000020 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 41431000021 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431000022 active site 41431000023 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000024 Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303 41431000025 inhibitor binding site; inhibition site 41431000026 catalytic motif [active] 41431000027 Catalytic residue [active] 41431000028 Active site flap [active] 41431000029 DDE superfamily endonuclease; Region: DDE_5; cl17874 41431000030 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000031 YcfA-like protein; Region: YcfA; pfam07927 41431000032 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 41431000033 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431000034 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431000035 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 41431000036 P-loop; other site 41431000037 Magnesium ion binding site [ion binding]; other site 41431000038 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 41431000039 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 41431000040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 41431000041 Transposase; Region: HTH_Tnp_1; cl17663 41431000042 Transposase; Region: DDE_Tnp_ISL3; pfam01610 41431000043 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431000044 active site 41431000045 NTP binding site [chemical binding]; other site 41431000046 metal binding triad [ion binding]; metal-binding site 41431000047 antibiotic binding site [chemical binding]; other site 41431000048 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 41431000049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 41431000050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 41431000051 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 41431000052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000053 DNA primase, catalytic core; Region: dnaG; TIGR01391 41431000054 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 41431000055 Phage associated DNA primase [General function prediction only]; Region: COG3378 41431000056 D5 N terminal like; Region: D5_N; pfam08706 41431000057 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 41431000058 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 41431000059 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000060 RHS Repeat; Region: RHS_repeat; cl11982 41431000061 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000062 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 41431000063 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 41431000064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431000065 dimerization interface [polypeptide binding]; other site 41431000066 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 41431000067 DDE superfamily endonuclease; Region: DDE_4; pfam13359 41431000068 HEAT repeats; Region: HEAT_2; pfam13646 41431000069 HEAT repeats; Region: HEAT_2; pfam13646 41431000070 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 41431000071 HEAT repeats; Region: HEAT_2; pfam13646 41431000072 protein binding surface [polypeptide binding]; other site 41431000073 HEAT repeats; Region: HEAT_2; pfam13646 41431000074 HEAT repeats; Region: HEAT_2; pfam13646 41431000075 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 41431000076 HEAT repeats; Region: HEAT_2; pfam13646 41431000077 protein binding surface [polypeptide binding]; other site 41431000078 HEAT repeats; Region: HEAT_2; pfam13646 41431000079 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000080 Phycobilisome protein; Region: Phycobilisome; cl08227 41431000081 Phycobilisome protein; Region: Phycobilisome; cl08227 41431000082 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247 41431000083 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13250 41431000084 Phycobilisome protein; Region: Phycobilisome; cl08227 41431000085 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431000086 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000087 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000088 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431000089 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000090 CpeS-like protein; Region: CpeS; pfam09367 41431000091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431000092 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431000093 Probable transposase; Region: OrfB_IS605; pfam01385 41431000094 Transposase IS200 like; Region: Y1_Tnp; pfam01797 41431000095 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 41431000096 CpeS-like protein; Region: CpeS; pfam09367 41431000097 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431000098 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 41431000099 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431000100 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 41431000101 PemK-like protein; Region: PemK; pfam02452 41431000102 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000103 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 41431000104 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 41431000105 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 41431000106 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 41431000107 Helix-turn-helix domain; Region: HTH_37; pfam13744 41431000108 Protein of unknown function (DUF433); Region: DUF433; pfam04255 41431000109 T-DNA border endonuclease VirD1; Region: VirD1; cl17530 41431000110 PemK-like protein; Region: PemK; pfam02452 41431000111 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 41431000112 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 41431000113 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 41431000114 active site 41431000115 DNA binding site [nucleotide binding] 41431000116 Int/Topo IB signature motif; other site 41431000117 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431000118 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431000119 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431000120 P-loop; other site 41431000121 Magnesium ion binding site [ion binding]; other site 41431000122 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431000123 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000124 putative active site [active] 41431000125 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 41431000126 DnaA N-terminal domain; Region: DnaA_N; pfam11638 41431000127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431000128 Walker A motif; other site 41431000129 ATP binding site [chemical binding]; other site 41431000130 Walker B motif; other site 41431000131 arginine finger; other site 41431000132 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 41431000133 DnaA box-binding interface [nucleotide binding]; other site 41431000134 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 41431000135 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431000136 phosphopeptide binding site; other site 41431000137 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431000138 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431000139 metal binding site [ion binding]; metal-binding site 41431000140 active site 41431000141 I-site; other site 41431000142 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 41431000143 Domain of unknown function (DUF427); Region: DUF427; cl00998 41431000144 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 41431000145 Clp amino terminal domain; Region: Clp_N; pfam02861 41431000146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431000147 Walker A motif; other site 41431000148 ATP binding site [chemical binding]; other site 41431000149 Walker B motif; other site 41431000150 arginine finger; other site 41431000151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431000152 Walker A motif; other site 41431000153 ATP binding site [chemical binding]; other site 41431000154 Walker B motif; other site 41431000155 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 41431000156 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431000157 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431000158 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 41431000159 Ligand binding site; other site 41431000160 Putative Catalytic site; other site 41431000161 DXD motif; other site 41431000162 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 41431000163 UbiA prenyltransferase family; Region: UbiA; pfam01040 41431000164 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 41431000165 nickel binding site [ion binding]; other site 41431000166 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431000167 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431000168 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 41431000169 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 41431000170 Protein of unknown function (DUF1390); Region: DUF1390; pfam07150 41431000171 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 41431000172 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 41431000173 active site 41431000174 catalytic tetrad [active] 41431000175 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 41431000176 RuvA N terminal domain; Region: RuvA_N; pfam01330 41431000177 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 41431000178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431000179 PAS fold; Region: PAS_3; pfam08447 41431000180 putative active site [active] 41431000181 heme pocket [chemical binding]; other site 41431000182 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431000183 GAF domain; Region: GAF_3; pfam13492 41431000184 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431000185 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431000186 metal binding site [ion binding]; metal-binding site 41431000187 active site 41431000188 I-site; other site 41431000189 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 41431000190 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 41431000191 substrate binding site [chemical binding]; other site 41431000192 ATP binding site [chemical binding]; other site 41431000193 Predicted methyltransferases [General function prediction only]; Region: COG0313 41431000194 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 41431000195 putative SAM binding site [chemical binding]; other site 41431000196 putative homodimer interface [polypeptide binding]; other site 41431000197 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000198 putative active site [active] 41431000199 Clp protease ATP binding subunit; Region: clpC; CHL00095 41431000200 Clp amino terminal domain; Region: Clp_N; pfam02861 41431000201 Clp amino terminal domain; Region: Clp_N; pfam02861 41431000202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431000203 Walker A motif; other site 41431000204 ATP binding site [chemical binding]; other site 41431000205 Walker B motif; other site 41431000206 arginine finger; other site 41431000207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431000208 Walker A motif; other site 41431000209 ATP binding site [chemical binding]; other site 41431000210 Walker B motif; other site 41431000211 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 41431000212 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431000213 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 41431000214 Phosphate acyltransferases; Region: PlsC; smart00563 41431000215 putative acyl-acceptor binding pocket; other site 41431000216 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 41431000217 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 41431000218 active site 41431000219 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 41431000220 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 41431000221 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 41431000222 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 41431000223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 41431000224 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 41431000225 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 41431000226 catalytic residues [active] 41431000227 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 41431000228 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 41431000229 Panthothenate kinase [Coenzyme metabolism]; Region: CoaA; COG1072 41431000230 enoyl-CoA hydratase; Provisional; Region: PRK06190 41431000231 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 41431000232 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 41431000233 metal binding site [ion binding]; metal-binding site 41431000234 dimer interface [polypeptide binding]; other site 41431000235 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 41431000236 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 41431000237 transmembrane helices; other site 41431000238 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 41431000239 TrkA-C domain; Region: TrkA_C; pfam02080 41431000240 TrkA-C domain; Region: TrkA_C; pfam02080 41431000241 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 41431000242 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 41431000243 putative ligand binding site [chemical binding]; other site 41431000244 putative catalytic site [active] 41431000245 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 41431000246 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 41431000247 NAD binding site [chemical binding]; other site 41431000248 homodimer interface [polypeptide binding]; other site 41431000249 active site 41431000250 substrate binding site [chemical binding]; other site 41431000251 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431000252 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431000253 active site 41431000254 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431000255 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431000256 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431000257 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 41431000258 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431000259 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 41431000260 active site 41431000261 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 41431000262 Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364 41431000263 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 41431000264 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 41431000265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431000266 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 41431000267 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 41431000268 classical (c) SDRs; Region: SDR_c; cd05233 41431000269 NAD(P) binding site [chemical binding]; other site 41431000270 active site 41431000271 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 41431000272 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 41431000273 putative ligand binding site [chemical binding]; other site 41431000274 putative NAD binding site [chemical binding]; other site 41431000275 catalytic site [active] 41431000276 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 41431000277 ligand binding site; other site 41431000278 tetramer interface; other site 41431000279 photosystem II 44 kDa protein; Region: psbC; CHL00035 41431000280 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 41431000281 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 41431000282 D1 interface; other site 41431000283 chlorophyll binding site; other site 41431000284 pheophytin binding site; other site 41431000285 beta carotene binding site; other site 41431000286 cytochrome b559 beta interface; other site 41431000287 quinone binding site; other site 41431000288 cytochrome b559 alpha interface; other site 41431000289 protein J interface; other site 41431000290 protein H interface; other site 41431000291 protein X interface; other site 41431000292 core light harvesting protein interface; other site 41431000293 protein L interface; other site 41431000294 CP43 interface; other site 41431000295 protein T interface; other site 41431000296 Fe binding site [ion binding]; other site 41431000297 protein M interface; other site 41431000298 Mn-stabilizing polypeptide interface; other site 41431000299 bromide binding site; other site 41431000300 cytochrome c-550 interface; other site 41431000301 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000302 putative active site [active] 41431000303 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 41431000304 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 41431000305 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 41431000306 Walker A/P-loop; other site 41431000307 ATP binding site [chemical binding]; other site 41431000308 Q-loop/lid; other site 41431000309 ABC transporter signature motif; other site 41431000310 Walker B; other site 41431000311 D-loop; other site 41431000312 H-loop/switch region; other site 41431000313 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 41431000314 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 41431000315 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 41431000316 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 41431000317 Ycf39; Provisional; Region: ycf39; CHL00194 41431000318 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 41431000319 NAD(P) binding site [chemical binding]; other site 41431000320 putative active site [active] 41431000321 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 41431000322 ATP-NAD kinase; Region: NAD_kinase; pfam01513 41431000323 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 41431000324 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 41431000325 substrate-cofactor binding pocket; other site 41431000326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431000327 catalytic residue [active] 41431000328 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 41431000329 proline aminopeptidase P II; Provisional; Region: PRK10879 41431000330 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 41431000331 active site 41431000332 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 41431000333 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 41431000334 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 41431000335 Peptidase family M48; Region: Peptidase_M48; cl12018 41431000336 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 41431000337 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 41431000338 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 41431000339 Zn2+ binding site [ion binding]; other site 41431000340 Mg2+ binding site [ion binding]; other site 41431000341 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 41431000342 Bacterial SH3 domain homologues; Region: SH3b; smart00287 41431000343 Bacterial SH3 domain; Region: SH3_3; cl17532 41431000344 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000345 putative active site [active] 41431000346 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 41431000347 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 41431000348 Mg++ binding site [ion binding]; other site 41431000349 putative catalytic motif [active] 41431000350 substrate binding site [chemical binding]; other site 41431000351 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 41431000352 Protein of unknown function, DUF393; Region: DUF393; cl01136 41431000353 Cupin domain; Region: Cupin_2; cl17218 41431000354 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 41431000355 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 41431000356 inhibitor-cofactor binding pocket; inhibition site 41431000357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431000358 catalytic residue [active] 41431000359 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 41431000360 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 41431000361 DNA binding residues [nucleotide binding] 41431000362 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431000363 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 41431000364 cofactor binding site; other site 41431000365 DNA binding site [nucleotide binding] 41431000366 substrate interaction site [chemical binding]; other site 41431000367 Uncharacterized conserved protein [Function unknown]; Region: COG0062 41431000368 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 41431000369 putative substrate binding site [chemical binding]; other site 41431000370 putative ATP binding site [chemical binding]; other site 41431000371 EVE domain; Region: EVE; pfam01878 41431000372 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 41431000373 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 41431000374 putative active site [active] 41431000375 metal binding site [ion binding]; metal-binding site 41431000376 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000377 putative active site [active] 41431000378 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431000379 Ligand Binding Site [chemical binding]; other site 41431000380 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 41431000381 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 41431000382 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 41431000383 putative active site pocket [active] 41431000384 4-fold oligomerization interface [polypeptide binding]; other site 41431000385 metal binding residues [ion binding]; metal-binding site 41431000386 3-fold/trimer interface [polypeptide binding]; other site 41431000387 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 41431000388 Double zinc ribbon; Region: DZR; pfam12773 41431000389 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 41431000390 Protein phosphatase 2C; Region: PP2C; pfam00481 41431000391 active site 41431000392 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 41431000393 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 41431000394 NADP binding site [chemical binding]; other site 41431000395 active site 41431000396 putative substrate binding site [chemical binding]; other site 41431000397 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 41431000398 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 41431000399 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 41431000400 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 41431000401 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 41431000402 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431000403 catalytic loop [active] 41431000404 iron binding site [ion binding]; other site 41431000405 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 41431000406 4Fe-4S binding domain; Region: Fer4; pfam00037 41431000407 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 41431000408 dimer interface [polypeptide binding]; other site 41431000409 [2Fe-2S] cluster binding site [ion binding]; other site 41431000410 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 41431000411 SLBB domain; Region: SLBB; pfam10531 41431000412 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 41431000413 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 41431000414 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 41431000415 putative dimer interface [polypeptide binding]; other site 41431000416 [2Fe-2S] cluster binding site [ion binding]; other site 41431000417 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000418 putative active site [active] 41431000419 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 41431000420 heme binding pocket [chemical binding]; other site 41431000421 heme ligand [chemical binding]; other site 41431000422 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 41431000423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431000424 FeS/SAM binding site; other site 41431000425 HemN C-terminal domain; Region: HemN_C; pfam06969 41431000426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 41431000427 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 41431000428 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 41431000429 FMN binding site [chemical binding]; other site 41431000430 active site 41431000431 substrate binding site [chemical binding]; other site 41431000432 catalytic residue [active] 41431000433 Cupin domain; Region: Cupin_2; pfam07883 41431000434 Predicted transcriptional regulators [Transcription]; Region: COG1733 41431000435 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 41431000436 TIGR00701 family protein; Region: TIGR00701 41431000437 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 41431000438 dimer interface [polypeptide binding]; other site 41431000439 FMN binding site [chemical binding]; other site 41431000440 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431000441 HSP70 interaction site [polypeptide binding]; other site 41431000442 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431000443 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000444 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000445 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000446 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 41431000447 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 41431000448 Proline dehydrogenase; Region: Pro_dh; pfam01619 41431000449 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 41431000450 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 41431000451 Glutamate binding site [chemical binding]; other site 41431000452 homodimer interface [polypeptide binding]; other site 41431000453 NAD binding site [chemical binding]; other site 41431000454 catalytic residues [active] 41431000455 GTP-binding protein Der; Reviewed; Region: PRK00093 41431000456 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 41431000457 G1 box; other site 41431000458 GTP/Mg2+ binding site [chemical binding]; other site 41431000459 Switch I region; other site 41431000460 G2 box; other site 41431000461 Switch II region; other site 41431000462 G3 box; other site 41431000463 G4 box; other site 41431000464 G5 box; other site 41431000465 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 41431000466 G1 box; other site 41431000467 GTP/Mg2+ binding site [chemical binding]; other site 41431000468 Switch I region; other site 41431000469 G2 box; other site 41431000470 G3 box; other site 41431000471 Switch II region; other site 41431000472 G4 box; other site 41431000473 G5 box; other site 41431000474 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000475 putative active site [active] 41431000476 Peptidase family M48; Region: Peptidase_M48; pfam01435 41431000477 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 41431000478 active site 41431000479 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431000480 active site 41431000481 ATP binding site [chemical binding]; other site 41431000482 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431000483 substrate binding site [chemical binding]; other site 41431000484 activation loop (A-loop); other site 41431000485 diaminopimelate decarboxylase; Region: lysA; TIGR01048 41431000486 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 41431000487 active site 41431000488 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 41431000489 substrate binding site [chemical binding]; other site 41431000490 catalytic residues [active] 41431000491 dimer interface [polypeptide binding]; other site 41431000492 TIGR00159 family protein; Region: TIGR00159 41431000493 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 41431000494 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 41431000495 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 41431000496 catalytic residue [active] 41431000497 putative FPP diphosphate binding site; other site 41431000498 putative FPP binding hydrophobic cleft; other site 41431000499 dimer interface [polypeptide binding]; other site 41431000500 putative IPP diphosphate binding site; other site 41431000501 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 41431000502 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 41431000503 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 41431000504 DNA binding site [nucleotide binding] 41431000505 catalytic residue [active] 41431000506 H2TH interface [polypeptide binding]; other site 41431000507 putative catalytic residues [active] 41431000508 turnover-facilitating residue; other site 41431000509 intercalation triad [nucleotide binding]; other site 41431000510 8OG recognition residue [nucleotide binding]; other site 41431000511 putative reading head residues; other site 41431000512 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 41431000513 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 41431000514 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 41431000515 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 41431000516 proline aminopeptidase P II; Provisional; Region: PRK10879 41431000517 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 41431000518 active site 41431000519 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 41431000520 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 41431000521 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 41431000522 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 41431000523 Predicted permeases [General function prediction only]; Region: COG0795 41431000524 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 41431000525 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 41431000526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431000527 NAD(P) binding site [chemical binding]; other site 41431000528 active site 41431000529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431000530 TPR motif; other site 41431000531 binding surface 41431000532 TPR repeat; Region: TPR_11; pfam13414 41431000533 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 41431000534 lipoprotein signal peptidase; Provisional; Region: PRK14787 41431000535 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 41431000536 biotin synthase; Region: bioB; TIGR00433 41431000537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431000538 FeS/SAM binding site; other site 41431000539 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 41431000540 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 41431000541 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 41431000542 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 41431000543 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431000544 XisI protein; Region: XisI; pfam08869 41431000545 XisH protein; Region: XisH; pfam08814 41431000546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431000547 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431000548 Probable transposase; Region: OrfB_IS605; pfam01385 41431000549 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431000550 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 41431000551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431000552 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431000553 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431000554 DNA binding residues [nucleotide binding] 41431000555 Divergent PAP2 family; Region: DUF212; pfam02681 41431000556 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 41431000557 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 41431000558 substrate binding pocket [chemical binding]; other site 41431000559 chain length determination region; other site 41431000560 substrate-Mg2+ binding site; other site 41431000561 catalytic residues [active] 41431000562 aspartate-rich region 1; other site 41431000563 active site lid residues [active] 41431000564 aspartate-rich region 2; other site 41431000565 Frequency clock protein; Region: FRQ; pfam09421 41431000566 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 41431000567 ABC1 family; Region: ABC1; cl17513 41431000568 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 41431000569 active site 41431000570 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 41431000571 putative active site [active] 41431000572 GUN4-like; Region: GUN4; pfam05419 41431000573 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 41431000574 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431000575 Coenzyme A binding pocket [chemical binding]; other site 41431000576 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 41431000577 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 41431000578 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431000579 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431000580 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431000581 DNA binding residues [nucleotide binding] 41431000582 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431000583 primosomal protein N' Region: priA; TIGR00595 41431000584 ATP binding site [chemical binding]; other site 41431000585 putative Mg++ binding site [ion binding]; other site 41431000586 helicase superfamily c-terminal domain; Region: HELICc; smart00490 41431000587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 41431000588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431000589 Coenzyme A binding pocket [chemical binding]; other site 41431000590 Protein of unknown function (DUF433); Region: DUF433; pfam04255 41431000591 YcfA-like protein; Region: YcfA; cl00752 41431000592 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 41431000593 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431000594 GAF domain; Region: GAF; pfam01590 41431000595 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431000596 geranylgeranyl reductase; Region: ChlP; TIGR02028 41431000597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 41431000598 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 41431000599 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 41431000600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431000601 Coenzyme A binding pocket [chemical binding]; other site 41431000602 Circadian oscillating protein COP23; Region: COP23; pfam14218 41431000603 CpeS-like protein; Region: CpeS; pfam09367 41431000604 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 41431000605 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 41431000606 GTP binding site; other site 41431000607 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 41431000608 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 41431000609 Ligand Binding Site [chemical binding]; other site 41431000610 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 41431000611 apolar tunnel; other site 41431000612 heme binding site [chemical binding]; other site 41431000613 dimerization interface [polypeptide binding]; other site 41431000614 Peptidase family M48; Region: Peptidase_M48; pfam01435 41431000615 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 41431000616 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 41431000617 putative active site [active] 41431000618 putative FMN binding site [chemical binding]; other site 41431000619 putative substrate binding site [chemical binding]; other site 41431000620 6-phosphofructokinase; Provisional; Region: PRK03202 41431000621 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 41431000622 active site 41431000623 ADP/pyrophosphate binding site [chemical binding]; other site 41431000624 dimerization interface [polypeptide binding]; other site 41431000625 allosteric effector site; other site 41431000626 fructose-1,6-bisphosphate binding site; other site 41431000627 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 41431000628 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 41431000629 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 41431000630 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 41431000631 catalytic site [active] 41431000632 G-X2-G-X-G-K; other site 41431000633 hypothetical protein; Provisional; Region: PRK04323 41431000634 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431000635 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431000636 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 41431000637 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 41431000638 [2Fe-2S] cluster binding site [ion binding]; other site 41431000639 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 41431000640 putative alpha subunit interface [polypeptide binding]; other site 41431000641 putative active site [active] 41431000642 putative substrate binding site [chemical binding]; other site 41431000643 Fe binding site [ion binding]; other site 41431000644 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 41431000645 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 41431000646 homodimer interface [polypeptide binding]; other site 41431000647 metal binding site [ion binding]; metal-binding site 41431000648 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 41431000649 homodimer interface [polypeptide binding]; other site 41431000650 active site 41431000651 putative chemical substrate binding site [chemical binding]; other site 41431000652 metal binding site [ion binding]; metal-binding site 41431000653 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 41431000654 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 41431000655 Catalytic site [active] 41431000656 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 41431000657 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 41431000658 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 41431000659 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 41431000660 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 41431000661 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 41431000662 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 41431000663 NAD binding site [chemical binding]; other site 41431000664 dimerization interface [polypeptide binding]; other site 41431000665 product binding site; other site 41431000666 substrate binding site [chemical binding]; other site 41431000667 zinc binding site [ion binding]; other site 41431000668 catalytic residues [active] 41431000669 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 41431000670 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 41431000671 active site 41431000672 catalytic tetrad [active] 41431000673 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 41431000674 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 41431000675 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431000676 peptide chain release factor 1; Validated; Region: prfA; PRK00591 41431000677 This domain is found in peptide chain release factors; Region: PCRF; smart00937 41431000678 RF-1 domain; Region: RF-1; pfam00472 41431000679 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 41431000680 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431000681 dimer interface [polypeptide binding]; other site 41431000682 putative metal binding site [ion binding]; other site 41431000683 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431000684 YcfA-like protein; Region: YcfA; cl00752 41431000685 AAA ATPase domain; Region: AAA_16; pfam13191 41431000686 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 41431000687 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431000688 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 41431000689 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 41431000690 substrate binding site [chemical binding]; other site 41431000691 ligand binding site [chemical binding]; other site 41431000692 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 41431000693 Protein of unknown function, DUF486; Region: DUF486; cl01236 41431000694 Transglycosylase; Region: Transgly; pfam00912 41431000695 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 41431000696 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 41431000697 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 41431000698 ribosomal protein L31; Validated; Region: rpl31; CHL00136 41431000699 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 41431000700 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 41431000701 23S rRNA interface [nucleotide binding]; other site 41431000702 L3 interface [polypeptide binding]; other site 41431000703 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 41431000704 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 41431000705 dimerization interface 3.5A [polypeptide binding]; other site 41431000706 active site 41431000707 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 41431000708 RNA polymerase alpha subunit; Region: rpoA; CHL00013 41431000709 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 41431000710 alphaNTD homodimer interface [polypeptide binding]; other site 41431000711 alphaNTD - beta interaction site [polypeptide binding]; other site 41431000712 alphaNTD - beta' interaction site [polypeptide binding]; other site 41431000713 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 41431000714 30S ribosomal protein S11; Validated; Region: PRK05309 41431000715 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 41431000716 30S ribosomal protein S13; Region: bact_S13; TIGR03631 41431000717 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 41431000718 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 41431000719 rRNA binding site [nucleotide binding]; other site 41431000720 predicted 30S ribosome binding site; other site 41431000721 adenylate kinase; Provisional; Region: adk; PRK02496 41431000722 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 41431000723 AMP-binding site [chemical binding]; other site 41431000724 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 41431000725 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 41431000726 SecY translocase; Region: SecY; pfam00344 41431000727 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 41431000728 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 41431000729 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 41431000730 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 41431000731 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 41431000732 23S rRNA interface [nucleotide binding]; other site 41431000733 L21e interface [polypeptide binding]; other site 41431000734 5S rRNA interface [nucleotide binding]; other site 41431000735 L27 interface [polypeptide binding]; other site 41431000736 L5 interface [polypeptide binding]; other site 41431000737 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 41431000738 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 41431000739 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 41431000740 ribosomal protein S8; Region: rps8; CHL00042 41431000741 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 41431000742 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 41431000743 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 41431000744 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 41431000745 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 41431000746 RNA binding site [nucleotide binding]; other site 41431000747 ribosomal protein L14; Region: rpl14; CHL00057 41431000748 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 41431000749 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 41431000750 putative translocon interaction site; other site 41431000751 23S rRNA interface [nucleotide binding]; other site 41431000752 signal recognition particle (SRP54) interaction site; other site 41431000753 L23 interface [polypeptide binding]; other site 41431000754 trigger factor interaction site; other site 41431000755 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 41431000756 23S rRNA interface [nucleotide binding]; other site 41431000757 5S rRNA interface [nucleotide binding]; other site 41431000758 putative antibiotic binding site [chemical binding]; other site 41431000759 L25 interface [polypeptide binding]; other site 41431000760 L27 interface [polypeptide binding]; other site 41431000761 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 41431000762 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 41431000763 G-X-X-G motif; other site 41431000764 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 41431000765 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 41431000766 putative translocon binding site; other site 41431000767 protein-rRNA interface [nucleotide binding]; other site 41431000768 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 41431000769 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 41431000770 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 41431000771 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 41431000772 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 41431000773 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 41431000774 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 41431000775 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 41431000776 UbiA prenyltransferase family; Region: UbiA; pfam01040 41431000777 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 41431000778 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 41431000779 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 41431000780 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 41431000781 substrate binding site [chemical binding]; other site 41431000782 oxyanion hole (OAH) forming residues; other site 41431000783 trimer interface [polypeptide binding]; other site 41431000784 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 41431000785 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 41431000786 RNase E interface [polypeptide binding]; other site 41431000787 trimer interface [polypeptide binding]; other site 41431000788 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 41431000789 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 41431000790 RNase E interface [polypeptide binding]; other site 41431000791 trimer interface [polypeptide binding]; other site 41431000792 active site 41431000793 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 41431000794 putative nucleic acid binding region [nucleotide binding]; other site 41431000795 G-X-X-G motif; other site 41431000796 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 41431000797 RNA binding site [nucleotide binding]; other site 41431000798 domain interface; other site 41431000799 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 41431000800 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 41431000801 putative catalytic site [active] 41431000802 putative metal binding site [ion binding]; other site 41431000803 putative phosphate binding site [ion binding]; other site 41431000804 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 41431000805 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 41431000806 Active Sites [active] 41431000807 Predicted permease; Region: DUF318; cl17795 41431000808 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 41431000809 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 41431000810 metal ion-dependent adhesion site (MIDAS); other site 41431000811 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 41431000812 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 41431000813 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 41431000814 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 41431000815 catalytic core [active] 41431000816 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431000817 putative active site [active] 41431000818 NAD synthetase; Provisional; Region: PRK13981 41431000819 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 41431000820 multimer interface [polypeptide binding]; other site 41431000821 active site 41431000822 catalytic triad [active] 41431000823 protein interface 1 [polypeptide binding]; other site 41431000824 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 41431000825 homodimer interface [polypeptide binding]; other site 41431000826 NAD binding pocket [chemical binding]; other site 41431000827 ATP binding pocket [chemical binding]; other site 41431000828 Mg binding site [ion binding]; other site 41431000829 active-site loop [active] 41431000830 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 41431000831 nudix motif; other site 41431000832 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 41431000833 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 41431000834 active site 41431000835 (T/H)XGH motif; other site 41431000836 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 41431000837 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 41431000838 active site 41431000839 Uncharacterized conserved protein [Function unknown]; Region: COG3937 41431000840 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 41431000841 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 41431000842 HflX GTPase family; Region: HflX; cd01878 41431000843 G1 box; other site 41431000844 GTP/Mg2+ binding site [chemical binding]; other site 41431000845 Switch I region; other site 41431000846 G2 box; other site 41431000847 G3 box; other site 41431000848 Switch II region; other site 41431000849 G4 box; other site 41431000850 G5 box; other site 41431000851 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 41431000852 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 41431000853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431000854 dimerization interface [polypeptide binding]; other site 41431000855 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 41431000856 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 41431000857 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 41431000858 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431000859 FtsH Extracellular; Region: FtsH_ext; pfam06480 41431000860 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 41431000861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431000862 Walker A motif; other site 41431000863 ATP binding site [chemical binding]; other site 41431000864 Walker B motif; other site 41431000865 arginine finger; other site 41431000866 Peptidase family M41; Region: Peptidase_M41; pfam01434 41431000867 Transcriptional regulator [Transcription]; Region: LysR; COG0583 41431000868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 41431000869 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 41431000870 putative effector binding pocket; other site 41431000871 dimerization interface [polypeptide binding]; other site 41431000872 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 41431000873 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 41431000874 Surface antigen; Region: Bac_surface_Ag; pfam01103 41431000875 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 41431000876 haemagglutination activity domain; Region: Haemagg_act; pfam05860 41431000877 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 41431000878 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 41431000879 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 41431000880 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 41431000881 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 41431000882 active site 41431000883 catalytic tetrad [active] 41431000884 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431000885 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000886 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000887 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431000888 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000889 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431000890 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 41431000891 SNF2 Helicase protein; Region: DUF3670; pfam12419 41431000892 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431000893 ATP binding site [chemical binding]; other site 41431000894 putative Mg++ binding site [ion binding]; other site 41431000895 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431000896 nucleotide binding region [chemical binding]; other site 41431000897 ATP-binding site [chemical binding]; other site 41431000898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 41431000899 conserved hypothetical protein; Region: TIGR03492 41431000900 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 41431000901 ligand binding site; other site 41431000902 tetramer interface; other site 41431000903 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 41431000904 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 41431000905 Walker A/P-loop; other site 41431000906 ATP binding site [chemical binding]; other site 41431000907 Q-loop/lid; other site 41431000908 ABC transporter signature motif; other site 41431000909 Walker B; other site 41431000910 D-loop; other site 41431000911 H-loop/switch region; other site 41431000912 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 41431000913 putative carbohydrate binding site [chemical binding]; other site 41431000914 Family description; Region: VCBS; pfam13517 41431000915 Family description; Region: VCBS; pfam13517 41431000916 Family description; Region: VCBS; pfam13517 41431000917 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 41431000918 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 41431000919 Methyltransferase domain; Region: Methyltransf_23; pfam13489 41431000920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431000921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 41431000922 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 41431000923 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 41431000924 Active_site [active] 41431000925 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 41431000926 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431000927 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431000928 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 41431000929 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 41431000930 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 41431000931 4Fe-4S binding domain; Region: Fer4_5; pfam12801 41431000932 4Fe-4S binding domain; Region: Fer4_5; pfam12801 41431000933 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431000934 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431000935 ligand binding site [chemical binding]; other site 41431000936 flexible hinge region; other site 41431000937 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431000938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431000939 binding surface 41431000940 TPR motif; other site 41431000941 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431000942 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431000943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431000944 Walker A/P-loop; other site 41431000945 ATP binding site [chemical binding]; other site 41431000946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431000947 Walker B; other site 41431000948 D-loop; other site 41431000949 H-loop/switch region; other site 41431000950 phytoene desaturase; Region: phytoene_desat; TIGR02731 41431000951 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 41431000952 Elongation factor TS; Region: EF_TS; pfam00889 41431000953 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 41431000954 active site lid residues [active] 41431000955 substrate binding pocket [chemical binding]; other site 41431000956 catalytic residues [active] 41431000957 substrate-Mg2+ binding site; other site 41431000958 aspartate-rich region 1; other site 41431000959 aspartate-rich region 2; other site 41431000960 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 41431000961 MAEBL; Provisional; Region: PTZ00121 41431000962 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 41431000963 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 41431000964 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 41431000965 Domain of unknown function (DUF814); Region: DUF814; pfam05670 41431000966 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 41431000967 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 41431000968 active site 41431000969 catalytic triad [active] 41431000970 oxyanion hole [active] 41431000971 ferrochelatase; Reviewed; Region: hemH; PRK00035 41431000972 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 41431000973 C-terminal domain interface [polypeptide binding]; other site 41431000974 active site 41431000975 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 41431000976 active site 41431000977 N-terminal domain interface [polypeptide binding]; other site 41431000978 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 41431000979 Methyltransferase domain; Region: Methyltransf_23; pfam13489 41431000980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431000981 S-adenosylmethionine binding site [chemical binding]; other site 41431000982 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 41431000983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431000984 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 41431000985 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 41431000986 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 41431000987 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 41431000988 TM-ABC transporter signature motif; other site 41431000989 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063 41431000990 nickel binding site [ion binding]; other site 41431000991 tocopherol O-methyltransferase; Region: PLN02244 41431000992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431000993 S-adenosylmethionine binding site [chemical binding]; other site 41431000994 TPR repeat; Region: TPR_11; pfam13414 41431000995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431000996 binding surface 41431000997 TPR motif; other site 41431000998 TPR repeat; Region: TPR_11; pfam13414 41431000999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001000 binding surface 41431001001 TPR motif; other site 41431001002 TPR repeat; Region: TPR_11; pfam13414 41431001003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001004 binding surface 41431001005 TPR motif; other site 41431001006 TPR repeat; Region: TPR_11; pfam13414 41431001007 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 41431001008 Protein of unknown function (DUF790); Region: DUF790; pfam05626 41431001009 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 41431001010 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 41431001011 catalytic residues [active] 41431001012 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 41431001013 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 41431001014 acyl-activating enzyme (AAE) consensus motif; other site 41431001015 putative AMP binding site [chemical binding]; other site 41431001016 putative active site [active] 41431001017 putative CoA binding site [chemical binding]; other site 41431001018 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 41431001019 Late competence development protein ComFB; Region: ComFB; pfam10719 41431001020 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 41431001021 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431001022 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431001023 DNA binding residues [nucleotide binding] 41431001024 Putative zinc-finger; Region: zf-HC2; pfam13490 41431001025 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 41431001026 putative active site pocket [active] 41431001027 dimerization interface [polypeptide binding]; other site 41431001028 putative catalytic residue [active] 41431001029 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 41431001030 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 41431001031 tartrate dehydrogenase; Region: TTC; TIGR02089 41431001032 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 41431001033 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 41431001034 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 41431001035 aromatic arch; other site 41431001036 DCoH dimer interaction site [polypeptide binding]; other site 41431001037 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 41431001038 DCoH tetramer interaction site [polypeptide binding]; other site 41431001039 substrate binding site [chemical binding]; other site 41431001040 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431001041 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 41431001042 non-specific DNA interactions [nucleotide binding]; other site 41431001043 DNA binding site [nucleotide binding] 41431001044 sequence specific DNA binding site [nucleotide binding]; other site 41431001045 putative cAMP binding site [chemical binding]; other site 41431001046 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 41431001047 nucleotide binding site [chemical binding]; other site 41431001048 substrate binding site [chemical binding]; other site 41431001049 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 41431001050 nucleotide binding site [chemical binding]; other site 41431001051 substrate binding site [chemical binding]; other site 41431001052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431001053 S-adenosylmethionine binding site [chemical binding]; other site 41431001054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 41431001055 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 41431001056 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 41431001057 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 41431001058 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 41431001059 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 41431001060 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431001061 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431001062 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 41431001063 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 41431001064 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 41431001065 Surface antigen; Region: Bac_surface_Ag; pfam01103 41431001066 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 41431001067 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 41431001068 ATP binding site [chemical binding]; other site 41431001069 active site 41431001070 substrate binding site [chemical binding]; other site 41431001071 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 41431001072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431001073 dimer interface [polypeptide binding]; other site 41431001074 conserved gate region; other site 41431001075 putative PBP binding loops; other site 41431001076 ABC-ATPase subunit interface; other site 41431001077 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 41431001078 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 41431001079 Restriction endonuclease; Region: Mrr_cat; pfam04471 41431001080 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431001081 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431001082 P-loop; other site 41431001083 Magnesium ion binding site [ion binding]; other site 41431001084 Ion channel; Region: Ion_trans_2; pfam07885 41431001085 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 41431001086 TrkA-N domain; Region: TrkA_N; pfam02254 41431001087 TrkA-C domain; Region: TrkA_C; pfam02080 41431001088 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 41431001089 FAD binding domain; Region: FAD_binding_4; pfam01565 41431001090 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 41431001091 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 41431001092 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 41431001093 active site 41431001094 Zn binding site [ion binding]; other site 41431001095 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 41431001096 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 41431001097 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 41431001098 active site 41431001099 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 41431001100 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 41431001101 SnoaL-like domain; Region: SnoaL_2; pfam12680 41431001102 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 41431001103 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 41431001104 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 41431001105 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 41431001106 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 41431001107 Homeodomain-like domain; Region: HTH_23; pfam13384 41431001108 Winged helix-turn helix; Region: HTH_29; pfam13551 41431001109 Winged helix-turn helix; Region: HTH_33; pfam13592 41431001110 DDE superfamily endonuclease; Region: DDE_3; pfam13358 41431001111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 41431001112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431001113 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431001114 Probable transposase; Region: OrfB_IS605; pfam01385 41431001115 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 41431001116 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 41431001117 substrate binding pocket [chemical binding]; other site 41431001118 chain length determination region; other site 41431001119 substrate-Mg2+ binding site; other site 41431001120 catalytic residues [active] 41431001121 aspartate-rich region 1; other site 41431001122 active site lid residues [active] 41431001123 aspartate-rich region 2; other site 41431001124 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 41431001125 ABC1 family; Region: ABC1; pfam03109 41431001126 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 41431001127 active site 41431001128 ATP binding site [chemical binding]; other site 41431001129 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 41431001130 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 41431001131 MOSC domain; Region: MOSC; pfam03473 41431001132 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 41431001133 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 41431001134 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 41431001135 PsaD; Region: PsaD; pfam02531 41431001136 Putative restriction endonuclease; Region: Uma2; pfam05685 41431001137 putative active site [active] 41431001138 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431001139 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 41431001140 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 41431001141 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 41431001142 catalytic site [active] 41431001143 subunit interface [polypeptide binding]; other site 41431001144 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 41431001145 DNA-binding interface [nucleotide binding]; DNA binding site 41431001146 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431001147 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001148 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001149 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001150 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001151 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001152 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001153 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 41431001154 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 41431001155 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 41431001156 protein binding site [polypeptide binding]; other site 41431001157 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 41431001158 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 41431001159 Ligand binding site; other site 41431001160 Putative Catalytic site; other site 41431001161 DXD motif; other site 41431001162 Domain of unknown function DUF; Region: DUF204; pfam02659 41431001163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431001164 S-adenosylmethionine binding site [chemical binding]; other site 41431001165 Methyltransferase domain; Region: Methyltransf_23; pfam13489 41431001166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431001167 S-adenosylmethionine binding site [chemical binding]; other site 41431001168 Predicted integral membrane protein [Function unknown]; Region: COG5617 41431001169 hypothetical protein; Reviewed; Region: PRK00024 41431001170 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 41431001171 MPN+ (JAMM) motif; other site 41431001172 Zinc-binding site [ion binding]; other site 41431001173 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431001174 putative active site [active] 41431001175 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 41431001176 homotrimer interaction site [polypeptide binding]; other site 41431001177 active site 41431001178 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 41431001179 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 41431001180 tandem repeat interface [polypeptide binding]; other site 41431001181 oligomer interface [polypeptide binding]; other site 41431001182 active site residues [active] 41431001183 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 41431001184 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 41431001185 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 41431001186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 41431001187 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 41431001188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 41431001189 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 41431001190 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 41431001191 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 41431001192 glutathione reductase; Validated; Region: PRK06116 41431001193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 41431001194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 41431001195 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 41431001196 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 41431001197 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 41431001198 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431001199 putative binding surface; other site 41431001200 active site 41431001201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431001202 ATP binding site [chemical binding]; other site 41431001203 Mg2+ binding site [ion binding]; other site 41431001204 G-X-G motif; other site 41431001205 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 41431001206 Response regulator receiver domain; Region: Response_reg; pfam00072 41431001207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431001208 active site 41431001209 phosphorylation site [posttranslational modification] 41431001210 intermolecular recognition site; other site 41431001211 dimerization interface [polypeptide binding]; other site 41431001212 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 41431001213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431001214 S-adenosylmethionine binding site [chemical binding]; other site 41431001215 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 41431001216 TPR repeat; Region: TPR_11; pfam13414 41431001217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001218 binding surface 41431001219 TPR motif; other site 41431001220 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 41431001221 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 41431001222 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 41431001223 putative DNA binding site [nucleotide binding]; other site 41431001224 putative Zn2+ binding site [ion binding]; other site 41431001225 Transcriptional regulator PadR-like family; Region: PadR; cl17335 41431001226 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 41431001227 putative ABC transporter; Region: ycf24; CHL00085 41431001228 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 41431001229 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 41431001230 Walker A/P-loop; other site 41431001231 ATP binding site [chemical binding]; other site 41431001232 Q-loop/lid; other site 41431001233 ABC transporter signature motif; other site 41431001234 Walker B; other site 41431001235 D-loop; other site 41431001236 H-loop/switch region; other site 41431001237 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 41431001238 FeS assembly protein SufD; Region: sufD; TIGR01981 41431001239 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 41431001240 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 41431001241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 41431001242 catalytic residue [active] 41431001243 30S ribosomal protein S1; Reviewed; Region: PRK07400 41431001244 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 41431001245 RNA binding site [nucleotide binding]; other site 41431001246 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 41431001247 RNA binding site [nucleotide binding]; other site 41431001248 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 41431001249 RNA binding site [nucleotide binding]; other site 41431001250 Dienelactone hydrolase family; Region: DLH; pfam01738 41431001251 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 41431001252 Cytochrome B6-F complex subunit 5; Region: PetG; pfam02529 41431001253 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 41431001254 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 41431001255 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 41431001256 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 41431001257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 41431001258 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824 41431001259 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 41431001260 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 41431001261 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431001262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431001263 active site 41431001264 phosphorylation site [posttranslational modification] 41431001265 intermolecular recognition site; other site 41431001266 dimerization interface [polypeptide binding]; other site 41431001267 PAS domain S-box; Region: sensory_box; TIGR00229 41431001268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431001269 putative active site [active] 41431001270 heme pocket [chemical binding]; other site 41431001271 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431001272 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431001273 metal binding site [ion binding]; metal-binding site 41431001274 active site 41431001275 I-site; other site 41431001276 PAS domain S-box; Region: sensory_box; TIGR00229 41431001277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431001278 putative active site [active] 41431001279 heme pocket [chemical binding]; other site 41431001280 PAS domain S-box; Region: sensory_box; TIGR00229 41431001281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431001282 putative active site [active] 41431001283 heme pocket [chemical binding]; other site 41431001284 PAS fold; Region: PAS_4; pfam08448 41431001285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431001286 PAS fold; Region: PAS_3; pfam08447 41431001287 putative active site [active] 41431001288 heme pocket [chemical binding]; other site 41431001289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431001290 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 41431001291 putative active site [active] 41431001292 heme pocket [chemical binding]; other site 41431001293 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431001294 putative active site [active] 41431001295 heme pocket [chemical binding]; other site 41431001296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 41431001297 Histidine kinase; Region: HisKA_2; pfam07568 41431001298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431001299 ATP binding site [chemical binding]; other site 41431001300 Mg2+ binding site [ion binding]; other site 41431001301 G-X-G motif; other site 41431001302 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 41431001303 AMP binding site [chemical binding]; other site 41431001304 fructose-1,6-bisphosphatase family protein; Region: PLN02628 41431001305 metal binding site [ion binding]; metal-binding site 41431001306 active site 41431001307 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 41431001308 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 41431001309 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 41431001310 catalytic triad [active] 41431001311 S-layer homology domain; Region: SLH; pfam00395 41431001312 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 41431001313 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 41431001314 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 41431001315 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 41431001316 dimer interface [polypeptide binding]; other site 41431001317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431001318 catalytic residue [active] 41431001319 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 41431001320 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431001321 HSP70 interaction site [polypeptide binding]; other site 41431001322 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 41431001323 putative homodimer interface [polypeptide binding]; other site 41431001324 putative homotetramer interface [polypeptide binding]; other site 41431001325 putative metal binding site [ion binding]; other site 41431001326 putative homodimer-homodimer interface [polypeptide binding]; other site 41431001327 putative allosteric switch controlling residues; other site 41431001328 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 41431001329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 41431001330 active site 41431001331 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 41431001332 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 41431001333 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 41431001334 active site 41431001335 dimer interface [polypeptide binding]; other site 41431001336 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 41431001337 dimer interface [polypeptide binding]; other site 41431001338 active site 41431001339 Uncharacterized conserved protein [Function unknown]; Region: COG1434 41431001340 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 41431001341 putative active site [active] 41431001342 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 41431001343 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 41431001344 homooctamer interface [polypeptide binding]; other site 41431001345 active site 41431001346 Rhomboid family; Region: Rhomboid; cl11446 41431001347 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431001348 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431001349 active site 41431001350 ATP binding site [chemical binding]; other site 41431001351 substrate binding site [chemical binding]; other site 41431001352 activation loop (A-loop); other site 41431001353 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 41431001354 Malic enzyme, N-terminal domain; Region: malic; pfam00390 41431001355 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 41431001356 putative NAD(P) binding site [chemical binding]; other site 41431001357 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 41431001358 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 41431001359 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 41431001360 active site 41431001361 catalytic residues [active] 41431001362 metal binding site [ion binding]; metal-binding site 41431001363 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 41431001364 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 41431001365 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431001366 catalytic loop [active] 41431001367 iron binding site [ion binding]; other site 41431001368 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431001369 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431001370 glycogen branching enzyme; Provisional; Region: PRK05402 41431001371 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 41431001372 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 41431001373 active site 41431001374 catalytic site [active] 41431001375 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 41431001376 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 41431001377 active site 41431001378 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 41431001379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431001380 Walker A motif; other site 41431001381 ATP binding site [chemical binding]; other site 41431001382 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 41431001383 dinuclear metal binding motif [ion binding]; other site 41431001384 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 41431001385 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 41431001386 active site 41431001387 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 41431001388 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 41431001389 active site 41431001390 HIGH motif; other site 41431001391 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 41431001392 KMSKS motif; other site 41431001393 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 41431001394 tRNA binding surface [nucleotide binding]; other site 41431001395 anticodon binding site; other site 41431001396 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431001397 CHAT domain; Region: CHAT; cl17868 41431001398 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 41431001399 TPR repeat; Region: TPR_11; pfam13414 41431001400 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431001401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001402 binding surface 41431001403 TPR motif; other site 41431001404 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431001405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001406 binding surface 41431001407 TPR motif; other site 41431001408 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431001409 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 41431001410 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 41431001411 active site 41431001412 homodimer interface [polypeptide binding]; other site 41431001413 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 41431001414 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 41431001415 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 41431001416 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 41431001417 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431001418 putative active site [active] 41431001419 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 41431001420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 41431001421 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 41431001422 putative dimerization interface [polypeptide binding]; other site 41431001423 Predicted membrane protein [Function unknown]; Region: COG4094 41431001424 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 41431001425 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 41431001426 TPP-binding site; other site 41431001427 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 41431001428 PYR/PP interface [polypeptide binding]; other site 41431001429 dimer interface [polypeptide binding]; other site 41431001430 TPP binding site [chemical binding]; other site 41431001431 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 41431001432 AAA domain; Region: AAA_23; pfam13476 41431001433 AAA domain; Region: AAA_21; pfam13304 41431001434 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 41431001435 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 41431001436 catalytic triad [active] 41431001437 dimer interface [polypeptide binding]; other site 41431001438 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 41431001439 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431001440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431001441 active site 41431001442 phosphorylation site [posttranslational modification] 41431001443 intermolecular recognition site; other site 41431001444 dimerization interface [polypeptide binding]; other site 41431001445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431001446 DNA binding site [nucleotide binding] 41431001447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431001448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431001449 dimerization interface [polypeptide binding]; other site 41431001450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431001451 dimer interface [polypeptide binding]; other site 41431001452 phosphorylation site [posttranslational modification] 41431001453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431001454 ATP binding site [chemical binding]; other site 41431001455 Mg2+ binding site [ion binding]; other site 41431001456 G-X-G motif; other site 41431001457 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 41431001458 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 41431001459 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 41431001460 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 41431001461 NADP binding site [chemical binding]; other site 41431001462 active site 41431001463 putative substrate binding site [chemical binding]; other site 41431001464 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 41431001465 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 41431001466 substrate binding site; other site 41431001467 metal-binding site 41431001468 Oligomer interface; other site 41431001469 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 41431001470 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 41431001471 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 41431001472 NAD binding site [chemical binding]; other site 41431001473 substrate binding site [chemical binding]; other site 41431001474 homodimer interface [polypeptide binding]; other site 41431001475 active site 41431001476 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 41431001477 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431001478 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431001479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431001480 dimer interface [polypeptide binding]; other site 41431001481 phosphorylation site [posttranslational modification] 41431001482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431001483 ATP binding site [chemical binding]; other site 41431001484 Mg2+ binding site [ion binding]; other site 41431001485 G-X-G motif; other site 41431001486 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 41431001487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 41431001488 Haemolysin XhlA; Region: XhlA; pfam10779 41431001489 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 41431001490 nucleoside/Zn binding site; other site 41431001491 dimer interface [polypeptide binding]; other site 41431001492 catalytic motif [active] 41431001493 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 41431001494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001495 NAD(P) binding site [chemical binding]; other site 41431001496 active site 41431001497 GrpE; Region: GrpE; pfam01025 41431001498 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 41431001499 dimer interface [polypeptide binding]; other site 41431001500 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 41431001501 molecular chaperone DnaK; Provisional; Region: PRK13411 41431001502 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 41431001503 nucleotide binding site [chemical binding]; other site 41431001504 NEF interaction site [polypeptide binding]; other site 41431001505 SBD interface [polypeptide binding]; other site 41431001506 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 41431001507 homotrimer interaction site [polypeptide binding]; other site 41431001508 putative active site [active] 41431001509 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 41431001510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431001511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431001512 homodimer interface [polypeptide binding]; other site 41431001513 catalytic residue [active] 41431001514 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 41431001515 HflK protein; Region: hflK; TIGR01933 41431001516 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 41431001517 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 41431001518 Protein export membrane protein; Region: SecD_SecF; cl14618 41431001519 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 41431001520 substrate binding pocket [chemical binding]; other site 41431001521 substrate-Mg2+ binding site; other site 41431001522 aspartate-rich region 1; other site 41431001523 aspartate-rich region 2; other site 41431001524 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 41431001525 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 41431001526 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 41431001527 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 41431001528 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 41431001529 CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159 41431001530 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869 41431001531 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 41431001532 CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174 41431001533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 41431001534 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 41431001535 Predicted transcriptional regulator [Transcription]; Region: COG2378 41431001536 WYL domain; Region: WYL; pfam13280 41431001537 Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094 41431001538 mce related protein; Region: MCE; pfam02470 41431001539 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 41431001540 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 41431001541 Walker A/P-loop; other site 41431001542 ATP binding site [chemical binding]; other site 41431001543 Q-loop/lid; other site 41431001544 ABC transporter signature motif; other site 41431001545 Walker B; other site 41431001546 D-loop; other site 41431001547 H-loop/switch region; other site 41431001548 Outer membrane efflux protein; Region: OEP; pfam02321 41431001549 Outer membrane efflux protein; Region: OEP; pfam02321 41431001550 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 41431001551 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 41431001552 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 41431001553 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 41431001554 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 41431001555 iron-sulfur cluster [ion binding]; other site 41431001556 [2Fe-2S] cluster binding site [ion binding]; other site 41431001557 Uncharacterized conserved protein [Function unknown]; Region: COG3349 41431001558 CHAT domain; Region: CHAT; cl17868 41431001559 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 41431001560 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 41431001561 Walker A/P-loop; other site 41431001562 ATP binding site [chemical binding]; other site 41431001563 Q-loop/lid; other site 41431001564 ABC transporter signature motif; other site 41431001565 Walker B; other site 41431001566 D-loop; other site 41431001567 H-loop/switch region; other site 41431001568 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 41431001569 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 41431001570 malate dehydrogenase; Reviewed; Region: PRK06223 41431001571 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 41431001572 NAD(P) binding site [chemical binding]; other site 41431001573 dimer interface [polypeptide binding]; other site 41431001574 tetramer (dimer of dimers) interface [polypeptide binding]; other site 41431001575 substrate binding site [chemical binding]; other site 41431001576 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 41431001577 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 41431001578 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 41431001579 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 41431001580 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431001581 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431001582 metal binding site [ion binding]; metal-binding site 41431001583 active site 41431001584 I-site; other site 41431001585 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 41431001586 arginine-tRNA ligase; Region: PLN02286 41431001587 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 41431001588 active site 41431001589 HIGH motif; other site 41431001590 KMSK motif region; other site 41431001591 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 41431001592 tRNA binding surface [nucleotide binding]; other site 41431001593 anticodon binding site; other site 41431001594 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 41431001595 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 41431001596 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 41431001597 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 41431001598 carboxyltransferase (CT) interaction site; other site 41431001599 biotinylation site [posttranslational modification]; other site 41431001600 HlyD family secretion protein; Region: HlyD_3; pfam13437 41431001601 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431001602 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431001603 ligand binding site [chemical binding]; other site 41431001604 flexible hinge region; other site 41431001605 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 41431001606 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 41431001607 putative active site [active] 41431001608 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 41431001609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431001610 Walker A/P-loop; other site 41431001611 ATP binding site [chemical binding]; other site 41431001612 Q-loop/lid; other site 41431001613 ABC transporter signature motif; other site 41431001614 Walker B; other site 41431001615 D-loop; other site 41431001616 H-loop/switch region; other site 41431001617 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 41431001618 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 41431001619 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 41431001620 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 41431001621 active site 41431001622 photosystem II reaction center protein K; Provisional; Region: psbK; PRK02553 41431001623 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 41431001624 ResB-like family; Region: ResB; pfam05140 41431001625 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 41431001626 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431001627 catalytic loop [active] 41431001628 iron binding site [ion binding]; other site 41431001629 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 41431001630 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 41431001631 active site 41431001632 dimerization interface [polypeptide binding]; other site 41431001633 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431001634 HSP70 interaction site [polypeptide binding]; other site 41431001635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001636 binding surface 41431001637 Tetratricopeptide repeat; Region: TPR_16; pfam13432 41431001638 TPR motif; other site 41431001639 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 41431001640 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 41431001641 molybdopterin cofactor binding site; other site 41431001642 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 41431001643 molybdopterin cofactor binding site; other site 41431001644 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 41431001645 active site 41431001646 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 41431001647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 41431001648 Protein of unknown function, DUF482; Region: DUF482; pfam04339 41431001649 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 41431001650 RibD C-terminal domain; Region: RibD_C; cl17279 41431001651 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001652 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431001653 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001654 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001655 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001656 CTP synthetase; Validated; Region: pyrG; PRK05380 41431001657 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 41431001658 Catalytic site [active] 41431001659 active site 41431001660 UTP binding site [chemical binding]; other site 41431001661 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 41431001662 active site 41431001663 putative oxyanion hole; other site 41431001664 catalytic triad [active] 41431001665 elongation factor P; Validated; Region: PRK00529 41431001666 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 41431001667 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 41431001668 RNA binding site [nucleotide binding]; other site 41431001669 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 41431001670 RNA binding site [nucleotide binding]; other site 41431001671 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 41431001672 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 41431001673 carboxyltransferase (CT) interaction site; other site 41431001674 biotinylation site [posttranslational modification]; other site 41431001675 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 41431001676 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 41431001677 hypothetical protein; Provisional; Region: PRK07236 41431001678 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 41431001679 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 41431001680 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 41431001681 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 41431001682 NACHT domain; Region: NACHT; pfam05729 41431001683 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431001684 HEAT repeats; Region: HEAT_2; pfam13646 41431001685 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 41431001686 GIY-YIG motif/motif A; other site 41431001687 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 41431001688 ATP-sulfurylase; Region: ATPS; cd00517 41431001689 active site 41431001690 HXXH motif; other site 41431001691 flexible loop; other site 41431001692 Caspase domain; Region: Peptidase_C14; pfam00656 41431001693 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 41431001694 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 41431001695 catalytic residues [active] 41431001696 DNA gyrase subunit A; Validated; Region: PRK05560 41431001697 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 41431001698 CAP-like domain; other site 41431001699 active site 41431001700 primary dimer interface [polypeptide binding]; other site 41431001701 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431001702 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431001703 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431001704 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431001705 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431001706 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431001707 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 41431001708 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431001709 ATP binding site [chemical binding]; other site 41431001710 putative Mg++ binding site [ion binding]; other site 41431001711 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431001712 nucleotide binding region [chemical binding]; other site 41431001713 ATP-binding site [chemical binding]; other site 41431001714 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 41431001715 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 41431001716 AAA ATPase domain; Region: AAA_16; pfam13191 41431001717 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 41431001718 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431001719 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431001720 structural tetrad; other site 41431001721 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431001722 structural tetrad; other site 41431001723 SIR2-like domain; Region: SIR2_2; pfam13289 41431001724 TIR domain; Region: TIR_2; pfam13676 41431001725 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 41431001726 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 41431001727 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 41431001728 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 41431001729 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 41431001730 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 41431001731 Subunit I/III interface [polypeptide binding]; other site 41431001732 signal recognition particle protein; Provisional; Region: PRK10867 41431001733 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 41431001734 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 41431001735 P loop; other site 41431001736 GTP binding site [chemical binding]; other site 41431001737 Signal peptide binding domain; Region: SRP_SPB; pfam02978 41431001738 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 41431001739 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 41431001740 NAD binding site [chemical binding]; other site 41431001741 ATP-grasp domain; Region: ATP-grasp; pfam02222 41431001742 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431001743 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001744 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431001745 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 41431001746 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 41431001747 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 41431001748 active site 41431001749 catalytic residues [active] 41431001750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 41431001751 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 41431001752 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 41431001753 active site 41431001754 chaperone protein DnaJ; Provisional; Region: PRK14276 41431001755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001756 TPR repeat; Region: TPR_11; pfam13414 41431001757 binding surface 41431001758 TPR motif; other site 41431001759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431001760 binding surface 41431001761 TPR repeat; Region: TPR_11; pfam13414 41431001762 TPR motif; other site 41431001763 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 41431001764 dimer interface [polypeptide binding]; other site 41431001765 catalytic triad [active] 41431001766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431001767 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431001768 Probable transposase; Region: OrfB_IS605; pfam01385 41431001769 Transposase IS200 like; Region: Y1_Tnp; pfam01797 41431001770 glutamate racemase; Provisional; Region: PRK00865 41431001771 AMIN domain; Region: AMIN; pfam11741 41431001772 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 41431001773 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 41431001774 active site 41431001775 metal binding site [ion binding]; metal-binding site 41431001776 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 41431001777 ArsC family; Region: ArsC; pfam03960 41431001778 catalytic residues [active] 41431001779 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 41431001780 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 41431001781 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 41431001782 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 41431001783 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431001784 putative active site [active] 41431001785 arogenate dehydrogenase; Reviewed; Region: PRK07417 41431001786 prephenate dehydrogenase; Validated; Region: PRK08507 41431001787 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 41431001788 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 41431001789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431001790 NAD(P) binding site [chemical binding]; other site 41431001791 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 41431001792 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 41431001793 DXD motif; other site 41431001794 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 41431001795 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 41431001796 Short C-terminal domain; Region: SHOCT; pfam09851 41431001797 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 41431001798 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 41431001799 putative hydrophobic ligand binding site [chemical binding]; other site 41431001800 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 41431001801 RimK-like ATP-grasp domain; Region: RimK; pfam08443 41431001802 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 41431001803 C-terminal peptidase (prc); Region: prc; TIGR00225 41431001804 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 41431001805 protein binding site [polypeptide binding]; other site 41431001806 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 41431001807 Catalytic dyad [active] 41431001808 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 41431001809 phosphoenolpyruvate synthase; Validated; Region: PRK06241 41431001810 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 41431001811 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 41431001812 Bacterial Ig-like domain; Region: Big_5; pfam13205 41431001813 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 41431001814 Resolvase, N terminal domain; Region: Resolvase; smart00857 41431001815 catalytic residues [active] 41431001816 Recombinase; Region: Recombinase; pfam07508 41431001817 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 41431001818 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 41431001819 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 41431001820 active site 41431001821 (T/H)XGH motif; other site 41431001822 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 41431001823 cell division protein; Validated; Region: ftsH; CHL00176 41431001824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431001825 Walker A motif; other site 41431001826 ATP binding site [chemical binding]; other site 41431001827 Walker B motif; other site 41431001828 arginine finger; other site 41431001829 Peptidase family M41; Region: Peptidase_M41; pfam01434 41431001830 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 41431001831 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 41431001832 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 41431001833 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 41431001834 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 41431001835 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 41431001836 putative active site [active] 41431001837 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 41431001838 Predicted ATPase [General function prediction only]; Region: COG4637 41431001839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431001840 Walker A/P-loop; other site 41431001841 ATP binding site [chemical binding]; other site 41431001842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431001843 Q-loop/lid; other site 41431001844 ABC transporter signature motif; other site 41431001845 Walker B; other site 41431001846 D-loop; other site 41431001847 H-loop/switch region; other site 41431001848 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 41431001849 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 41431001850 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431001851 NAD binding site [chemical binding]; other site 41431001852 substrate binding site [chemical binding]; other site 41431001853 active site 41431001854 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 41431001855 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 41431001856 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 41431001857 TIGR02646 family protein; Region: TIGR02646 41431001858 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 41431001859 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 41431001860 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 41431001861 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 41431001862 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 41431001863 ATP-grasp domain; Region: ATP-grasp_4; cl17255 41431001864 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 41431001865 IMP binding site; other site 41431001866 dimer interface [polypeptide binding]; other site 41431001867 interdomain contacts; other site 41431001868 partial ornithine binding site; other site 41431001869 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 41431001870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431001871 Walker A/P-loop; other site 41431001872 ATP binding site [chemical binding]; other site 41431001873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431001874 ABC transporter signature motif; other site 41431001875 Walker B; other site 41431001876 D-loop; other site 41431001877 H-loop/switch region; other site 41431001878 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 41431001879 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431001880 substrate binding pocket [chemical binding]; other site 41431001881 membrane-bound complex binding site; other site 41431001882 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 41431001883 Peptidase family M23; Region: Peptidase_M23; pfam01551 41431001884 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 41431001885 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 41431001886 RibD C-terminal domain; Region: RibD_C; cl17279 41431001887 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 41431001888 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 41431001889 DNA protecting protein DprA; Region: dprA; TIGR00732 41431001890 Methyltransferase domain; Region: Methyltransf_23; pfam13489 41431001891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431001892 S-adenosylmethionine binding site [chemical binding]; other site 41431001893 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 41431001894 Fatty acid desaturase; Region: FA_desaturase; pfam00487 41431001895 Di-iron ligands [ion binding]; other site 41431001896 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 41431001897 Aluminium resistance protein; Region: Alum_res; pfam06838 41431001898 Homeodomain-like domain; Region: HTH_23; pfam13384 41431001899 Winged helix-turn helix; Region: HTH_29; pfam13551 41431001900 Homeodomain-like domain; Region: HTH_32; pfam13565 41431001901 DDE superfamily endonuclease; Region: DDE_3; pfam13358 41431001902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 41431001903 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 41431001904 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 41431001905 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 41431001906 dimerization interface [polypeptide binding]; other site 41431001907 active site 41431001908 metal binding site [ion binding]; metal-binding site 41431001909 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 41431001910 dimerization interface [polypeptide binding]; other site 41431001911 active site 41431001912 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 41431001913 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 41431001914 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 41431001915 active site 41431001916 catalytic site [active] 41431001917 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 41431001918 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 41431001919 oligomer interface [polypeptide binding]; other site 41431001920 metal binding site [ion binding]; metal-binding site 41431001921 metal binding site [ion binding]; metal-binding site 41431001922 Cl binding site [ion binding]; other site 41431001923 aspartate ring; other site 41431001924 basic sphincter; other site 41431001925 putative hydrophobic gate; other site 41431001926 periplasmic entrance; other site 41431001927 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 41431001928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431001929 Coenzyme A binding pocket [chemical binding]; other site 41431001930 Uncharacterized conserved protein [Function unknown]; Region: COG1432 41431001931 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 41431001932 putative metal binding site [ion binding]; other site 41431001933 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 41431001934 tellurium resistance terB-like protein; Region: terB_like; cd07177 41431001935 metal binding site [ion binding]; metal-binding site 41431001936 16S rRNA methyltransferase B; Provisional; Region: PRK14901 41431001937 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 41431001938 putative RNA binding site [nucleotide binding]; other site 41431001939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431001940 S-adenosylmethionine binding site [chemical binding]; other site 41431001941 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 41431001942 metal ion-dependent adhesion site (MIDAS); other site 41431001943 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 41431001944 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 41431001945 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 41431001946 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 41431001947 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 41431001948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 41431001949 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 41431001950 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 41431001951 B12 binding site [chemical binding]; other site 41431001952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 41431001953 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 41431001954 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 41431001955 anti sigma factor interaction site; other site 41431001956 regulatory phosphorylation site [posttranslational modification]; other site 41431001957 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 41431001958 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 41431001959 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 41431001960 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 41431001961 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 41431001962 putative active site [active] 41431001963 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 41431001964 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431001965 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431001966 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431001967 DNA binding residues [nucleotide binding] 41431001968 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 41431001969 light-harvesting-like protein 3; Provisional; Region: PLN00014 41431001970 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431001971 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431001972 structural tetrad; other site 41431001973 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 41431001974 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 41431001975 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 41431001976 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 41431001977 active site 41431001978 HIGH motif; other site 41431001979 nucleotide binding site [chemical binding]; other site 41431001980 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 41431001981 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 41431001982 active site 41431001983 KMSKS motif; other site 41431001984 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 41431001985 tRNA binding surface [nucleotide binding]; other site 41431001986 anticodon binding site; other site 41431001987 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 41431001988 phosphodiesterase; Provisional; Region: PRK12704 41431001989 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 41431001990 aromatic arch; other site 41431001991 DCoH dimer interaction site [polypeptide binding]; other site 41431001992 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 41431001993 DCoH tetramer interaction site [polypeptide binding]; other site 41431001994 substrate binding site [chemical binding]; other site 41431001995 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 41431001996 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 41431001997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 41431001998 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 41431001999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431002000 motif II; other site 41431002001 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 41431002002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431002003 FeS/SAM binding site; other site 41431002004 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 41431002005 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 41431002006 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 41431002007 Ligand Binding Site [chemical binding]; other site 41431002008 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 41431002009 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 41431002010 substrate binding site [chemical binding]; other site 41431002011 glutamase interaction surface [polypeptide binding]; other site 41431002012 Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA; cl00012 41431002013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 41431002014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431002015 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 41431002016 Coenzyme A binding pocket [chemical binding]; other site 41431002017 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 41431002018 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 41431002019 homodimer interface [polypeptide binding]; other site 41431002020 active site 41431002021 TDP-binding site; other site 41431002022 acceptor substrate-binding pocket; other site 41431002023 MarR family; Region: MarR_2; pfam12802 41431002024 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 41431002025 Methyltransferase domain; Region: Methyltransf_31; pfam13847 41431002026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431002027 S-adenosylmethionine binding site [chemical binding]; other site 41431002028 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431002029 putative active site [active] 41431002030 GMP synthase; Reviewed; Region: guaA; PRK00074 41431002031 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 41431002032 AMP/PPi binding site [chemical binding]; other site 41431002033 candidate oxyanion hole; other site 41431002034 catalytic triad [active] 41431002035 potential glutamine specificity residues [chemical binding]; other site 41431002036 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 41431002037 ATP Binding subdomain [chemical binding]; other site 41431002038 Ligand Binding sites [chemical binding]; other site 41431002039 Dimerization subdomain; other site 41431002040 L-aspartate oxidase; Provisional; Region: PRK07395 41431002041 L-aspartate oxidase; Provisional; Region: PRK06175 41431002042 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 41431002043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431002044 TPR repeat; Region: TPR_11; pfam13414 41431002045 TPR motif; other site 41431002046 HEAT repeats; Region: HEAT_2; pfam13646 41431002047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002048 TPR motif; other site 41431002049 TPR repeat; Region: TPR_11; pfam13414 41431002050 binding surface 41431002051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002052 TPR motif; other site 41431002053 TPR repeat; Region: TPR_11; pfam13414 41431002054 binding surface 41431002055 TPR repeat; Region: TPR_11; pfam13414 41431002056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002057 binding surface 41431002058 TPR motif; other site 41431002059 TPR repeat; Region: TPR_11; pfam13414 41431002060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002061 binding surface 41431002062 TPR motif; other site 41431002063 TPR repeat; Region: TPR_11; pfam13414 41431002064 TPR repeat; Region: TPR_11; pfam13414 41431002065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002066 binding surface 41431002067 TPR repeat; Region: TPR_11; pfam13414 41431002068 TPR motif; other site 41431002069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002070 TPR motif; other site 41431002071 TPR repeat; Region: TPR_11; pfam13414 41431002072 binding surface 41431002073 TPR repeat; Region: TPR_11; pfam13414 41431002074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002075 binding surface 41431002076 TPR motif; other site 41431002077 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 41431002078 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 41431002079 Chromate transporter; Region: Chromate_transp; pfam02417 41431002080 DNA photolyase; Region: DNA_photolyase; pfam00875 41431002081 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 41431002082 GUN4-like; Region: GUN4; pfam05419 41431002083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431002084 AAA domain; Region: AAA_21; pfam13304 41431002085 Walker A/P-loop; other site 41431002086 ATP binding site [chemical binding]; other site 41431002087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431002088 Walker B; other site 41431002089 D-loop; other site 41431002090 H-loop/switch region; other site 41431002091 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431002092 putative active site [active] 41431002093 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 41431002094 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 41431002095 GDP-binding site [chemical binding]; other site 41431002096 ACT binding site; other site 41431002097 IMP binding site; other site 41431002098 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 41431002099 5S rRNA interface [nucleotide binding]; other site 41431002100 CTC domain interface [polypeptide binding]; other site 41431002101 L16 interface [polypeptide binding]; other site 41431002102 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431002103 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 41431002104 metal-binding site 41431002105 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 41431002106 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431002107 active site 41431002108 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 41431002109 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 41431002110 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 41431002111 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 41431002112 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 41431002113 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 41431002114 Dehydroquinase class II; Region: DHquinase_II; pfam01220 41431002115 trimer interface [polypeptide binding]; other site 41431002116 active site 41431002117 dimer interface [polypeptide binding]; other site 41431002118 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 41431002119 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 41431002120 Walker A/P-loop; other site 41431002121 ATP binding site [chemical binding]; other site 41431002122 Q-loop/lid; other site 41431002123 ABC transporter signature motif; other site 41431002124 Walker B; other site 41431002125 D-loop; other site 41431002126 H-loop/switch region; other site 41431002127 Ferredoxin [Energy production and conversion]; Region: COG1146 41431002128 Class I aldolases; Region: Aldolase_Class_I; cl17187 41431002129 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 41431002130 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431002131 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 41431002132 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002133 TPR repeat; Region: TPR_11; pfam13414 41431002134 binding surface 41431002135 TPR motif; other site 41431002136 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431002137 dimerization interface [polypeptide binding]; other site 41431002138 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431002139 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 41431002140 dimer interface [polypeptide binding]; other site 41431002141 putative CheW interface [polypeptide binding]; other site 41431002142 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431002143 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431002144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002145 active site 41431002146 phosphorylation site [posttranslational modification] 41431002147 intermolecular recognition site; other site 41431002148 dimerization interface [polypeptide binding]; other site 41431002149 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 41431002150 Response regulator receiver domain; Region: Response_reg; pfam00072 41431002151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002152 active site 41431002153 phosphorylation site [posttranslational modification] 41431002154 intermolecular recognition site; other site 41431002155 dimerization interface [polypeptide binding]; other site 41431002156 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 41431002157 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 41431002158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 41431002159 non-specific DNA binding site [nucleotide binding]; other site 41431002160 salt bridge; other site 41431002161 sequence-specific DNA binding site [nucleotide binding]; other site 41431002162 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 41431002163 PIN domain; Region: PIN_3; cl17397 41431002164 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 41431002165 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 41431002166 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 41431002167 active site 41431002168 dimer interface [polypeptide binding]; other site 41431002169 motif 1; other site 41431002170 motif 2; other site 41431002171 motif 3; other site 41431002172 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 41431002173 anticodon binding site; other site 41431002174 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 41431002175 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431002176 phosphopeptide binding site; other site 41431002177 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 41431002178 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 41431002179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431002180 Walker A/P-loop; other site 41431002181 ATP binding site [chemical binding]; other site 41431002182 Q-loop/lid; other site 41431002183 ABC transporter signature motif; other site 41431002184 Walker B; other site 41431002185 D-loop; other site 41431002186 H-loop/switch region; other site 41431002187 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431002188 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431002189 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431002190 ligand binding site [chemical binding]; other site 41431002191 flexible hinge region; other site 41431002192 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 41431002193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 41431002194 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 41431002195 calmodulin; Provisional; Region: PTZ00184 41431002196 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 41431002197 Ca2+ binding site [ion binding]; other site 41431002198 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 41431002199 Ca2+ binding site [ion binding]; other site 41431002200 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431002201 cobalt transport protein CbiM; Validated; Region: PRK06265 41431002202 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 41431002203 PDGLE domain; Region: PDGLE; pfam13190 41431002204 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 41431002205 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 41431002206 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 41431002207 ligand binding site; other site 41431002208 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 41431002209 active site 41431002210 metal binding site [ion binding]; metal-binding site 41431002211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431002212 AAA domain; Region: AAA_23; pfam13476 41431002213 AAA domain; Region: AAA_21; pfam13304 41431002214 Walker A/P-loop; other site 41431002215 ATP binding site [chemical binding]; other site 41431002216 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 41431002217 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 41431002218 RNA binding surface [nucleotide binding]; other site 41431002219 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 41431002220 active site 41431002221 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 41431002222 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 41431002223 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 41431002224 NAD(P) binding site [chemical binding]; other site 41431002225 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431002226 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002227 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431002228 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002229 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002230 HEAT repeats; Region: HEAT_2; pfam13646 41431002231 HEAT repeats; Region: HEAT_2; pfam13646 41431002232 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 41431002233 HEAT repeat; Region: HEAT; pfam02985 41431002234 HEAT repeats; Region: HEAT_2; pfam13646 41431002235 HEAT-like repeat; Region: HEAT_EZ; pfam13513 41431002236 HEAT repeats; Region: HEAT_2; pfam13646 41431002237 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431002238 apocytochrome f; Reviewed; Region: PRK02693 41431002239 cytochrome f; Region: petA; CHL00037 41431002240 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 41431002241 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 41431002242 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 41431002243 cytochrome b subunit interaction site [polypeptide binding]; other site 41431002244 [2Fe-2S] cluster binding site [ion binding]; other site 41431002245 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 41431002246 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 41431002247 dimer interface [polypeptide binding]; other site 41431002248 active site 41431002249 glycine-pyridoxal phosphate binding site [chemical binding]; other site 41431002250 folate binding site [chemical binding]; other site 41431002251 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 41431002252 Response regulator receiver domain; Region: Response_reg; pfam00072 41431002253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002254 active site 41431002255 phosphorylation site [posttranslational modification] 41431002256 intermolecular recognition site; other site 41431002257 dimerization interface [polypeptide binding]; other site 41431002258 CHASE3 domain; Region: CHASE3; cl05000 41431002259 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 41431002260 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431002261 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 41431002262 dimer interface [polypeptide binding]; other site 41431002263 putative CheW interface [polypeptide binding]; other site 41431002264 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431002265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 41431002266 dimer interface [polypeptide binding]; other site 41431002267 putative CheW interface [polypeptide binding]; other site 41431002268 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 41431002269 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431002270 putative binding surface; other site 41431002271 active site 41431002272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431002273 ATP binding site [chemical binding]; other site 41431002274 Mg2+ binding site [ion binding]; other site 41431002275 G-X-G motif; other site 41431002276 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431002277 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431002278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002279 active site 41431002280 phosphorylation site [posttranslational modification] 41431002281 intermolecular recognition site; other site 41431002282 dimerization interface [polypeptide binding]; other site 41431002283 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 41431002284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002285 active site 41431002286 phosphorylation site [posttranslational modification] 41431002287 intermolecular recognition site; other site 41431002288 dimerization interface [polypeptide binding]; other site 41431002289 CheB methylesterase; Region: CheB_methylest; pfam01339 41431002290 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 41431002291 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 41431002292 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 41431002293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002294 binding surface 41431002295 TPR motif; other site 41431002296 Tetratricopeptide repeat; Region: TPR_16; pfam13432 41431002297 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 41431002298 CheW-like domain; Region: CheW; pfam01584 41431002299 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 41431002300 Pheophorbide a oxygenase; Region: PaO; pfam08417 41431002301 elongation factor G; Reviewed; Region: PRK00007 41431002302 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 41431002303 G1 box; other site 41431002304 putative GEF interaction site [polypeptide binding]; other site 41431002305 GTP/Mg2+ binding site [chemical binding]; other site 41431002306 Switch I region; other site 41431002307 G2 box; other site 41431002308 G3 box; other site 41431002309 Switch II region; other site 41431002310 G4 box; other site 41431002311 G5 box; other site 41431002312 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 41431002313 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 41431002314 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 41431002315 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 41431002316 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 41431002317 NodB motif; other site 41431002318 active site 41431002319 catalytic site [active] 41431002320 metal binding site [ion binding]; metal-binding site 41431002321 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 41431002322 MoaE homodimer interface [polypeptide binding]; other site 41431002323 MoaD interaction [polypeptide binding]; other site 41431002324 active site residues [active] 41431002325 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 41431002326 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 41431002327 intersubunit interface [polypeptide binding]; other site 41431002328 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 41431002329 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 41431002330 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 41431002331 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 41431002332 ABC-ATPase subunit interface; other site 41431002333 dimer interface [polypeptide binding]; other site 41431002334 putative PBP binding regions; other site 41431002335 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 41431002336 dimer interface [polypeptide binding]; other site 41431002337 active site 41431002338 aspartate-rich active site metal binding site; other site 41431002339 allosteric magnesium binding site [ion binding]; other site 41431002340 Schiff base residues; other site 41431002341 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 41431002342 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 41431002343 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 41431002344 catalytic residue [active] 41431002345 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 41431002346 active site 41431002347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431002348 S-adenosylmethionine binding site [chemical binding]; other site 41431002349 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 41431002350 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431002351 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 41431002352 active site 41431002353 metal binding site [ion binding]; metal-binding site 41431002354 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431002355 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002356 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002357 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 41431002358 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 41431002359 Hexamer interface [polypeptide binding]; other site 41431002360 Hexagonal pore residue; other site 41431002361 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 41431002362 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 41431002363 Hexamer interface [polypeptide binding]; other site 41431002364 Hexagonal pore residue; other site 41431002365 quinolinate synthetase; Provisional; Region: PRK09375 41431002366 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 41431002367 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 41431002368 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 41431002369 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 41431002370 P-loop; other site 41431002371 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 41431002372 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 41431002373 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 41431002374 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431002375 dimerization interface [polypeptide binding]; other site 41431002376 PAS domain; Region: PAS_9; pfam13426 41431002377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431002378 putative active site [active] 41431002379 heme pocket [chemical binding]; other site 41431002380 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 41431002381 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 41431002382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 41431002383 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 41431002384 anti sigma factor interaction site; other site 41431002385 regulatory phosphorylation site [posttranslational modification]; other site 41431002386 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 41431002387 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 41431002388 Peptidase family M23; Region: Peptidase_M23; pfam01551 41431002389 homoserine dehydrogenase; Provisional; Region: PRK06349 41431002390 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 41431002391 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 41431002392 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 41431002393 hydrolase, alpha/beta fold family protein; Region: PLN02824 41431002394 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 41431002395 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 41431002396 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 41431002397 Predicted integral membrane protein [Function unknown]; Region: COG0392 41431002398 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 41431002399 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 41431002400 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 41431002401 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 41431002402 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 41431002403 Glucose inhibited division protein A; Region: GIDA; pfam01134 41431002404 allophycocyanin, beta subunit; Region: apcB; TIGR01337 41431002405 glutamine synthetase, type I; Region: GlnA; TIGR00653 41431002406 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 41431002407 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 41431002408 Class I aldolases; Region: Aldolase_Class_I; cl17187 41431002409 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431002410 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 41431002411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002412 active site 41431002413 phosphorylation site [posttranslational modification] 41431002414 intermolecular recognition site; other site 41431002415 dimerization interface [polypeptide binding]; other site 41431002416 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 41431002417 Zn2+ binding site [ion binding]; other site 41431002418 Mg2+ binding site [ion binding]; other site 41431002419 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; pfam05430 41431002420 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 41431002421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 41431002422 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 41431002423 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 41431002424 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 41431002425 active site 41431002426 competence damage-inducible protein A; Provisional; Region: PRK00549 41431002427 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 41431002428 putative MPT binding site; other site 41431002429 Competence-damaged protein; Region: CinA; pfam02464 41431002430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002431 TPR motif; other site 41431002432 TPR repeat; Region: TPR_11; pfam13414 41431002433 binding surface 41431002434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002435 binding surface 41431002436 TPR repeat; Region: TPR_11; pfam13414 41431002437 TPR motif; other site 41431002438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431002439 hybrid cluster protein; Provisional; Region: PRK05290 41431002440 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 41431002441 ACS interaction site; other site 41431002442 CODH interaction site; other site 41431002443 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 41431002444 ACS interaction site; other site 41431002445 CODH interaction site; other site 41431002446 metal cluster binding site [ion binding]; other site 41431002447 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 41431002448 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 41431002449 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 41431002450 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 41431002451 active site 41431002452 substrate binding site [chemical binding]; other site 41431002453 metal binding site [ion binding]; metal-binding site 41431002454 PAS domain S-box; Region: sensory_box; TIGR00229 41431002455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431002456 putative active site [active] 41431002457 heme pocket [chemical binding]; other site 41431002458 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431002459 GAF domain; Region: GAF; pfam01590 41431002460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431002461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431002462 dimer interface [polypeptide binding]; other site 41431002463 phosphorylation site [posttranslational modification] 41431002464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431002465 ATP binding site [chemical binding]; other site 41431002466 Mg2+ binding site [ion binding]; other site 41431002467 G-X-G motif; other site 41431002468 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431002469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002470 active site 41431002471 phosphorylation site [posttranslational modification] 41431002472 intermolecular recognition site; other site 41431002473 dimerization interface [polypeptide binding]; other site 41431002474 Response regulator receiver domain; Region: Response_reg; pfam00072 41431002475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002476 active site 41431002477 phosphorylation site [posttranslational modification] 41431002478 intermolecular recognition site; other site 41431002479 dimerization interface [polypeptide binding]; other site 41431002480 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431002481 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431002482 metal binding site [ion binding]; metal-binding site 41431002483 active site 41431002484 I-site; other site 41431002485 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431002486 FAD binding domain; Region: FAD_binding_4; pfam01565 41431002487 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 41431002488 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431002489 active site 41431002490 metal binding site [ion binding]; metal-binding site 41431002491 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 41431002492 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 41431002493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431002494 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 41431002495 Coenzyme A binding pocket [chemical binding]; other site 41431002496 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 41431002497 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 41431002498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 41431002499 HdeA/HdeB family; Region: HdeA; cl05752 41431002500 2-isopropylmalate synthase; Validated; Region: PRK00915 41431002501 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 41431002502 active site 41431002503 catalytic residues [active] 41431002504 metal binding site [ion binding]; metal-binding site 41431002505 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 41431002506 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 41431002507 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 41431002508 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 41431002509 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431002510 putative active site [active] 41431002511 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 41431002512 Transposase IS200 like; Region: Y1_Tnp; pfam01797 41431002513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431002514 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431002515 Probable transposase; Region: OrfB_IS605; pfam01385 41431002516 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 41431002517 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 41431002518 transketolase; Region: PLN02790 41431002519 TPP-binding site [chemical binding]; other site 41431002520 dimer interface [polypeptide binding]; other site 41431002521 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 41431002522 PYR/PP interface [polypeptide binding]; other site 41431002523 dimer interface [polypeptide binding]; other site 41431002524 TPP binding site [chemical binding]; other site 41431002525 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 41431002526 glycogen synthase; Provisional; Region: glgA; PRK00654 41431002527 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 41431002528 ADP-binding pocket [chemical binding]; other site 41431002529 homodimer interface [polypeptide binding]; other site 41431002530 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 41431002531 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 41431002532 active site 41431002533 interdomain interaction site; other site 41431002534 putative metal-binding site [ion binding]; other site 41431002535 nucleotide binding site [chemical binding]; other site 41431002536 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 41431002537 domain I; other site 41431002538 phosphate binding site [ion binding]; other site 41431002539 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 41431002540 domain II; other site 41431002541 domain III; other site 41431002542 nucleotide binding site [chemical binding]; other site 41431002543 DNA binding groove [nucleotide binding] 41431002544 catalytic site [active] 41431002545 domain IV; other site 41431002546 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 41431002547 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 41431002548 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 41431002549 light-harvesting-like protein 3; Provisional; Region: PLN00014 41431002550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002551 active site 41431002552 phosphorylation site [posttranslational modification] 41431002553 intermolecular recognition site; other site 41431002554 dimerization interface [polypeptide binding]; other site 41431002555 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431002556 metal binding site [ion binding]; metal-binding site 41431002557 active site 41431002558 I-site; other site 41431002559 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431002560 Photosystem I protein M (PsaM); Region: PsaM; pfam07465 41431002561 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431002562 YcfA-like protein; Region: YcfA; pfam07927 41431002563 methionine sulfoxide reductase B; Provisional; Region: PRK00222 41431002564 SelR domain; Region: SelR; pfam01641 41431002565 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 41431002566 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 41431002567 C-terminal domain interface [polypeptide binding]; other site 41431002568 GSH binding site (G-site) [chemical binding]; other site 41431002569 dimer interface [polypeptide binding]; other site 41431002570 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 41431002571 N-terminal domain interface [polypeptide binding]; other site 41431002572 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 41431002573 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 41431002574 dimer interface [polypeptide binding]; other site 41431002575 putative anticodon binding site; other site 41431002576 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 41431002577 motif 1; other site 41431002578 active site 41431002579 motif 2; other site 41431002580 motif 3; other site 41431002581 KTSC domain; Region: KTSC; pfam13619 41431002582 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 41431002583 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431002584 active site 41431002585 ATP binding site [chemical binding]; other site 41431002586 substrate binding site [chemical binding]; other site 41431002587 activation loop (A-loop); other site 41431002588 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431002589 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002590 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002591 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 41431002592 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 41431002593 active site 41431002594 Zn binding site [ion binding]; other site 41431002595 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 41431002596 dimerization interface [polypeptide binding]; other site 41431002597 putative DNA binding site [nucleotide binding]; other site 41431002598 putative Zn2+ binding site [ion binding]; other site 41431002599 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 41431002600 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 41431002601 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 41431002602 P-loop, Walker A motif; other site 41431002603 Base recognition motif; other site 41431002604 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 41431002605 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431002606 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 41431002607 structural tetrad; other site 41431002608 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 41431002609 homodecamer interface [polypeptide binding]; other site 41431002610 GTP cyclohydrolase I; Provisional; Region: PLN03044 41431002611 active site 41431002612 putative catalytic site residues [active] 41431002613 zinc binding site [ion binding]; other site 41431002614 GTP-CH-I/GFRP interaction surface; other site 41431002615 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 41431002616 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 41431002617 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 41431002618 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 41431002619 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 41431002620 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 41431002621 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 41431002622 putative active site [active] 41431002623 putative metal binding site [ion binding]; other site 41431002624 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 41431002625 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 41431002626 metal binding site 2 [ion binding]; metal-binding site 41431002627 putative DNA binding helix; other site 41431002628 metal binding site 1 [ion binding]; metal-binding site 41431002629 dimer interface [polypeptide binding]; other site 41431002630 structural Zn2+ binding site [ion binding]; other site 41431002631 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 41431002632 acyl-ACP reductase; Provisional; Region: PRK14982 41431002633 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 41431002634 NAD(P) binding pocket [chemical binding]; other site 41431002635 WAX2 C-terminal domain; Region: Wax2_C; pfam12076 41431002636 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 41431002637 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 41431002638 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 41431002639 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 41431002640 active site residue [active] 41431002641 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 41431002642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431002643 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431002644 Probable transposase; Region: OrfB_IS605; pfam01385 41431002645 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431002646 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 41431002647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002648 binding surface 41431002649 TPR repeat; Region: TPR_11; pfam13414 41431002650 TPR motif; other site 41431002651 TPR repeat; Region: TPR_11; pfam13414 41431002652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002653 binding surface 41431002654 TPR motif; other site 41431002655 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 41431002656 tyrosine decarboxylase; Region: PLN02880 41431002657 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 41431002658 catalytic residue [active] 41431002659 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 41431002660 putative active site [active] 41431002661 putative metal binding site [ion binding]; other site 41431002662 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 41431002663 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 41431002664 substrate binding site [chemical binding]; other site 41431002665 ATP binding site [chemical binding]; other site 41431002666 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 41431002667 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 41431002668 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 41431002669 active site 41431002670 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431002671 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431002672 ligand binding site [chemical binding]; other site 41431002673 flexible hinge region; other site 41431002674 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 41431002675 putative switch regulator; other site 41431002676 non-specific DNA interactions [nucleotide binding]; other site 41431002677 DNA binding site [nucleotide binding] 41431002678 sequence specific DNA binding site [nucleotide binding]; other site 41431002679 putative cAMP binding site [chemical binding]; other site 41431002680 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 41431002681 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 41431002682 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 41431002683 ABC-ATPase subunit interface; other site 41431002684 dimer interface [polypeptide binding]; other site 41431002685 putative PBP binding regions; other site 41431002686 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431002687 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 41431002688 NAD binding site [chemical binding]; other site 41431002689 putative substrate binding site 2 [chemical binding]; other site 41431002690 putative substrate binding site 1 [chemical binding]; other site 41431002691 active site 41431002692 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 41431002693 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 41431002694 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 41431002695 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 41431002696 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 41431002697 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 41431002698 Phosphotransferase enzyme family; Region: APH; pfam01636 41431002699 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 41431002700 active site 41431002701 ATP binding site [chemical binding]; other site 41431002702 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 41431002703 substrate binding site [chemical binding]; other site 41431002704 alanine racemase; Reviewed; Region: alr; PRK00053 41431002705 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 41431002706 active site 41431002707 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 41431002708 dimer interface [polypeptide binding]; other site 41431002709 substrate binding site [chemical binding]; other site 41431002710 catalytic residues [active] 41431002711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431002712 AAA domain; Region: AAA_21; pfam13304 41431002713 Walker A/P-loop; other site 41431002714 ATP binding site [chemical binding]; other site 41431002715 RHS Repeat; Region: RHS_repeat; cl11982 41431002716 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 41431002717 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 41431002718 PYR/PP interface [polypeptide binding]; other site 41431002719 dimer interface [polypeptide binding]; other site 41431002720 TPP binding site [chemical binding]; other site 41431002721 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 41431002722 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 41431002723 TPP-binding site [chemical binding]; other site 41431002724 dimer interface [polypeptide binding]; other site 41431002725 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 41431002726 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 41431002727 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 41431002728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431002729 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431002730 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 41431002731 Probable Catalytic site; other site 41431002732 metal-binding site 41431002733 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 41431002734 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 41431002735 Probable Catalytic site; other site 41431002736 metal-binding site 41431002737 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431002738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431002739 NAD(P) binding site [chemical binding]; other site 41431002740 active site 41431002741 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 41431002742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431002743 S-adenosylmethionine binding site [chemical binding]; other site 41431002744 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 41431002745 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 41431002746 short chain dehydrogenase; Provisional; Region: PRK07454 41431002747 classical (c) SDRs; Region: SDR_c; cd05233 41431002748 NAD(P) binding site [chemical binding]; other site 41431002749 active site 41431002750 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 41431002751 homodecamer interface [polypeptide binding]; other site 41431002752 GTP cyclohydrolase I; Provisional; Region: PLN03044 41431002753 active site 41431002754 putative catalytic site residues [active] 41431002755 zinc binding site [ion binding]; other site 41431002756 GTP-CH-I/GFRP interaction surface; other site 41431002757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 41431002758 FIST N domain; Region: FIST; pfam08495 41431002759 FIST C domain; Region: FIST_C; pfam10442 41431002760 CP12 domain; Region: CP12; pfam02672 41431002761 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 41431002762 TPR repeat; Region: TPR_11; pfam13414 41431002763 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 41431002764 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 41431002765 putative ligand binding site [chemical binding]; other site 41431002766 von Willebrand factor type A domain; Region: VWA_2; pfam13519 41431002767 Tubulin like; Region: Tubulin_2; pfam13809 41431002768 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 41431002769 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 41431002770 Peptidase family M50; Region: Peptidase_M50; pfam02163 41431002771 active site 41431002772 putative substrate binding region [chemical binding]; other site 41431002773 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 41431002774 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 41431002775 hydrolase, alpha/beta fold family protein; Region: PLN02824 41431002776 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 41431002777 ScpA/B protein; Region: ScpA_ScpB; pfam02616 41431002778 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 41431002779 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 41431002780 active site 41431002781 Substrate binding site; other site 41431002782 Mg++ binding site; other site 41431002783 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 41431002784 putative trimer interface [polypeptide binding]; other site 41431002785 putative CoA binding site [chemical binding]; other site 41431002786 PAS fold; Region: PAS_4; pfam08448 41431002787 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431002788 putative active site [active] 41431002789 heme pocket [chemical binding]; other site 41431002790 GAF domain; Region: GAF_3; pfam13492 41431002791 GAF domain; Region: GAF_2; pfam13185 41431002792 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431002793 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431002794 metal binding site [ion binding]; metal-binding site 41431002795 active site 41431002796 I-site; other site 41431002797 Chemotaxis phosphatase CheX; Region: CheX; cl15816 41431002798 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 41431002799 Response regulator receiver domain; Region: Response_reg; pfam00072 41431002800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431002801 active site 41431002802 phosphorylation site [posttranslational modification] 41431002803 intermolecular recognition site; other site 41431002804 dimerization interface [polypeptide binding]; other site 41431002805 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431002806 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431002807 active site 41431002808 ATP binding site [chemical binding]; other site 41431002809 substrate binding site [chemical binding]; other site 41431002810 activation loop (A-loop); other site 41431002811 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 41431002812 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 41431002813 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 41431002814 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 41431002815 HEAT repeats; Region: HEAT_2; pfam13646 41431002816 HEAT repeats; Region: HEAT_2; pfam13646 41431002817 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 41431002818 TIR domain; Region: TIR_2; pfam13676 41431002819 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431002820 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431002821 structural tetrad; other site 41431002822 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431002823 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431002824 structural tetrad; other site 41431002825 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 41431002826 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 41431002827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 41431002828 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 41431002829 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 41431002830 AAA domain; Region: AAA_21; pfam13304 41431002831 Walker A/P-loop; other site 41431002832 ATP binding site [chemical binding]; other site 41431002833 Q-loop/lid; other site 41431002834 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 41431002835 ABC transporter signature motif; other site 41431002836 Walker B; other site 41431002837 D-loop; other site 41431002838 H-loop/switch region; other site 41431002839 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 41431002840 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 41431002841 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 41431002842 Walker A/P-loop; other site 41431002843 ATP binding site [chemical binding]; other site 41431002844 Q-loop/lid; other site 41431002845 ABC transporter signature motif; other site 41431002846 Walker B; other site 41431002847 D-loop; other site 41431002848 H-loop/switch region; other site 41431002849 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 41431002850 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 41431002851 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 41431002852 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 41431002853 oligomer interface [polypeptide binding]; other site 41431002854 active site residues [active] 41431002855 Clp protease; Region: CLP_protease; pfam00574 41431002856 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 41431002857 oligomer interface [polypeptide binding]; other site 41431002858 active site residues [active] 41431002859 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431002860 recombinase A; Provisional; Region: recA; PRK09354 41431002861 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 41431002862 hexamer interface [polypeptide binding]; other site 41431002863 Walker A motif; other site 41431002864 ATP binding site [chemical binding]; other site 41431002865 Walker B motif; other site 41431002866 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 41431002867 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 41431002868 Zn binding site [ion binding]; other site 41431002869 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 41431002870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431002871 S-adenosylmethionine binding site [chemical binding]; other site 41431002872 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 41431002873 Short C-terminal domain; Region: SHOCT; pfam09851 41431002874 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 41431002875 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 41431002876 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002877 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431002878 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 41431002879 shikimate kinase; Reviewed; Region: aroK; PRK00131 41431002880 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 41431002881 ADP binding site [chemical binding]; other site 41431002882 magnesium binding site [ion binding]; other site 41431002883 putative shikimate binding site; other site 41431002884 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 41431002885 Clp amino terminal domain; Region: Clp_N; pfam02861 41431002886 Clp amino terminal domain; Region: Clp_N; pfam02861 41431002887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431002888 Walker A motif; other site 41431002889 ATP binding site [chemical binding]; other site 41431002890 Walker B motif; other site 41431002891 arginine finger; other site 41431002892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431002893 Walker A motif; other site 41431002894 ATP binding site [chemical binding]; other site 41431002895 Walker B motif; other site 41431002896 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 41431002897 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 41431002898 IHF - DNA interface [nucleotide binding]; other site 41431002899 IHF dimer interface [polypeptide binding]; other site 41431002900 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 41431002901 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 41431002902 proposed catalytic triad [active] 41431002903 active site nucleophile [active] 41431002904 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 41431002905 ATP-grasp domain; Region: ATP-grasp_4; cl17255 41431002906 ATP-grasp domain; Region: ATP-grasp_4; cl17255 41431002907 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 41431002908 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431002909 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431002910 putative active site [active] 41431002911 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 41431002912 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 41431002913 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431002914 GAF domain; Region: GAF; pfam01590 41431002915 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431002916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431002917 dimer interface [polypeptide binding]; other site 41431002918 phosphorylation site [posttranslational modification] 41431002919 TPR repeat; Region: TPR_11; pfam13414 41431002920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431002921 binding surface 41431002922 TPR motif; other site 41431002923 TPR repeat; Region: TPR_11; pfam13414 41431002924 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 41431002925 intersubunit interface [polypeptide binding]; other site 41431002926 active site 41431002927 zinc binding site [ion binding]; other site 41431002928 Na+ binding site [ion binding]; other site 41431002929 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 41431002930 EamA-like transporter family; Region: EamA; pfam00892 41431002931 EamA-like transporter family; Region: EamA; pfam00892 41431002932 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 41431002933 heterotetramer interface [polypeptide binding]; other site 41431002934 active site pocket [active] 41431002935 cleavage site 41431002936 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 41431002937 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 41431002938 putative acyl-acceptor binding pocket; other site 41431002939 phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293 41431002940 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 41431002941 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 41431002942 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 41431002943 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 41431002944 active site 41431002945 zinc binding site [ion binding]; other site 41431002946 Uncharacterized conserved protein [Function unknown]; Region: COG2898 41431002947 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 41431002948 Predicted integral membrane protein [Function unknown]; Region: COG0392 41431002949 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 41431002950 Putative esterase; Region: Esterase; pfam00756 41431002951 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 41431002952 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 41431002953 chaperone protein DnaJ; Provisional; Region: PRK14299 41431002954 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431002955 HSP70 interaction site [polypeptide binding]; other site 41431002956 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 41431002957 dimer interface [polypeptide binding]; other site 41431002958 molecular chaperone DnaK; Provisional; Region: PRK13410 41431002959 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 41431002960 nucleotide binding site [chemical binding]; other site 41431002961 NEF interaction site [polypeptide binding]; other site 41431002962 SBD interface [polypeptide binding]; other site 41431002963 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 41431002964 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 41431002965 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 41431002966 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 41431002967 putative active site; other site 41431002968 catalytic triad [active] 41431002969 putative dimer interface [polypeptide binding]; other site 41431002970 gamma-glutamyl kinase; Provisional; Region: PRK05429 41431002971 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 41431002972 nucleotide binding site [chemical binding]; other site 41431002973 homotetrameric interface [polypeptide binding]; other site 41431002974 putative phosphate binding site [ion binding]; other site 41431002975 putative allosteric binding site; other site 41431002976 PUA domain; Region: PUA; pfam01472 41431002977 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 41431002978 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 41431002979 putative catalytic site [active] 41431002980 putative phosphate binding site [ion binding]; other site 41431002981 active site 41431002982 metal binding site A [ion binding]; metal-binding site 41431002983 DNA binding site [nucleotide binding] 41431002984 putative AP binding site [nucleotide binding]; other site 41431002985 putative metal binding site B [ion binding]; other site 41431002986 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 41431002987 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431002988 cofactor binding site; other site 41431002989 DNA binding site [nucleotide binding] 41431002990 substrate interaction site [chemical binding]; other site 41431002991 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431002992 ketol-acid reductoisomerase; Provisional; Region: PRK05479 41431002993 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 41431002994 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 41431002995 PIN domain; Region: PIN_3; pfam13470 41431002996 Transposase IS200 like; Region: Y1_Tnp; cl00848 41431002997 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 41431002998 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 41431002999 putative substrate binding site [chemical binding]; other site 41431003000 putative ATP binding site [chemical binding]; other site 41431003001 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 41431003002 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003003 putative active site [active] 41431003004 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 41431003005 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 41431003006 dimer interface [polypeptide binding]; other site 41431003007 tetramer interface [polypeptide binding]; other site 41431003008 PYR/PP interface [polypeptide binding]; other site 41431003009 TPP binding site [chemical binding]; other site 41431003010 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 41431003011 TPP-binding site; other site 41431003012 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 41431003013 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 41431003014 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 41431003015 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 41431003016 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 41431003017 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 41431003018 putative ligand binding site [chemical binding]; other site 41431003019 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431003020 dimerization interface [polypeptide binding]; other site 41431003021 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003022 PAS domain; Region: PAS_9; pfam13426 41431003023 putative active site [active] 41431003024 heme pocket [chemical binding]; other site 41431003025 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 41431003026 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 41431003027 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 41431003028 Fasciclin domain; Region: Fasciclin; pfam02469 41431003029 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 41431003030 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 41431003031 B12 binding site [chemical binding]; other site 41431003032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431003033 FeS/SAM binding site; other site 41431003034 NADH dehydrogenase; Region: NADHdh; cl00469 41431003035 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 41431003036 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 41431003037 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 41431003038 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 41431003039 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 41431003040 NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015 41431003041 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 41431003042 Fasciclin domain; Region: Fasciclin; pfam02469 41431003043 DNA polymerase III subunit beta; Validated; Region: PRK05643 41431003044 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 41431003045 putative DNA binding surface [nucleotide binding]; other site 41431003046 dimer interface [polypeptide binding]; other site 41431003047 beta-clamp/clamp loader binding surface; other site 41431003048 beta-clamp/translesion DNA polymerase binding surface; other site 41431003049 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 41431003050 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 41431003051 Walker A/P-loop; other site 41431003052 ATP binding site [chemical binding]; other site 41431003053 Q-loop/lid; other site 41431003054 ABC transporter signature motif; other site 41431003055 Walker B; other site 41431003056 D-loop; other site 41431003057 H-loop/switch region; other site 41431003058 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 41431003059 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 41431003060 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 41431003061 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 41431003062 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 41431003063 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 41431003064 Walker A/P-loop; other site 41431003065 ATP binding site [chemical binding]; other site 41431003066 Q-loop/lid; other site 41431003067 ABC transporter signature motif; other site 41431003068 Walker B; other site 41431003069 D-loop; other site 41431003070 H-loop/switch region; other site 41431003071 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 41431003072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431003073 dimer interface [polypeptide binding]; other site 41431003074 conserved gate region; other site 41431003075 putative PBP binding loops; other site 41431003076 ABC-ATPase subunit interface; other site 41431003077 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 41431003078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431003079 dimer interface [polypeptide binding]; other site 41431003080 conserved gate region; other site 41431003081 putative PBP binding loops; other site 41431003082 ABC-ATPase subunit interface; other site 41431003083 PBP superfamily domain; Region: PBP_like_2; cl17296 41431003084 threonine synthase; Reviewed; Region: PRK06721 41431003085 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 41431003086 homodimer interface [polypeptide binding]; other site 41431003087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431003088 catalytic residue [active] 41431003089 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 41431003090 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431003091 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431003092 Magnesium ion binding site [ion binding]; other site 41431003093 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 41431003094 active site 41431003095 SAM binding site [chemical binding]; other site 41431003096 homodimer interface [polypeptide binding]; other site 41431003097 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 41431003098 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 41431003099 active site 41431003100 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 41431003101 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 41431003102 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 41431003103 Walker A/P-loop; other site 41431003104 ATP binding site [chemical binding]; other site 41431003105 Q-loop/lid; other site 41431003106 ABC transporter signature motif; other site 41431003107 Walker B; other site 41431003108 D-loop; other site 41431003109 H-loop/switch region; other site 41431003110 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431003111 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 41431003112 putative ADP-binding pocket [chemical binding]; other site 41431003113 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003114 putative active site [active] 41431003115 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 41431003116 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431003117 ATP binding site [chemical binding]; other site 41431003118 putative Mg++ binding site [ion binding]; other site 41431003119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431003120 nucleotide binding region [chemical binding]; other site 41431003121 ATP-binding site [chemical binding]; other site 41431003122 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 41431003123 HRDC domain; Region: HRDC; pfam00570 41431003124 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 41431003125 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 41431003126 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 41431003127 hinge; other site 41431003128 active site 41431003129 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 41431003130 Putative esterase; Region: Esterase; pfam00756 41431003131 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 41431003132 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 41431003133 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 41431003134 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 41431003135 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 41431003136 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 41431003137 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 41431003138 active site 41431003139 catalytic site [active] 41431003140 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 41431003141 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 41431003142 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 41431003143 TrkA-N domain; Region: TrkA_N; pfam02254 41431003144 TrkA-C domain; Region: TrkA_C; pfam02080 41431003145 integral membrane protein MviN; Region: mviN; TIGR01695 41431003146 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 41431003147 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 41431003148 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 41431003149 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 41431003150 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 41431003151 V4R domain; Region: V4R; pfam02830 41431003152 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 41431003153 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 41431003154 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 41431003155 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431003156 catalytic loop [active] 41431003157 iron binding site [ion binding]; other site 41431003158 Phycobilisome protein; Region: Phycobilisome; cl08227 41431003159 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 41431003160 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431003161 catalytic loop [active] 41431003162 iron binding site [ion binding]; other site 41431003163 TPR repeat; Region: TPR_11; pfam13414 41431003164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003165 binding surface 41431003166 TPR motif; other site 41431003167 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 41431003168 Mrr N-terminal domain; Region: Mrr_N; pfam14338 41431003169 Restriction endonuclease; Region: Mrr_cat; pfam04471 41431003170 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 41431003171 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 41431003172 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 41431003173 catalytic residue [active] 41431003174 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 41431003175 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 41431003176 homodimer interface [polypeptide binding]; other site 41431003177 oligonucleotide binding site [chemical binding]; other site 41431003178 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 41431003179 RNA/DNA hybrid binding site [nucleotide binding]; other site 41431003180 active site 41431003181 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 41431003182 prephenate dehydratase; Provisional; Region: PRK11898 41431003183 Prephenate dehydratase; Region: PDT; pfam00800 41431003184 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 41431003185 putative L-Phe binding site [chemical binding]; other site 41431003186 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 41431003187 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 41431003188 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 41431003189 putative active site [active] 41431003190 catalytic site [active] 41431003191 putative metal binding site [ion binding]; other site 41431003192 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 41431003193 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 41431003194 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431003195 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 41431003196 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431003197 ATP binding site [chemical binding]; other site 41431003198 putative Mg++ binding site [ion binding]; other site 41431003199 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 41431003200 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 41431003201 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 41431003202 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 41431003203 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 41431003204 Pantoate-beta-alanine ligase; Region: PanC; cd00560 41431003205 active site 41431003206 ATP-binding site [chemical binding]; other site 41431003207 pantoate-binding site; other site 41431003208 HXXH motif; other site 41431003209 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 41431003210 CMP-binding site; other site 41431003211 The sites determining sugar specificity; other site 41431003212 yiaA/B two helix domain; Region: YiaAB; cl01759 41431003213 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 41431003214 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 41431003215 substrate binding site [chemical binding]; other site 41431003216 ATP binding site [chemical binding]; other site 41431003217 Predicted membrane protein [Function unknown]; Region: COG2119 41431003218 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 41431003219 Predicted membrane protein [Function unknown]; Region: COG2119 41431003220 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 41431003221 S-formylglutathione hydrolase; Region: PLN02442 41431003222 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 41431003223 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 41431003224 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 41431003225 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 41431003226 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 41431003227 GIY-YIG motif/motif A; other site 41431003228 active site 41431003229 catalytic site [active] 41431003230 putative DNA binding site [nucleotide binding]; other site 41431003231 metal binding site [ion binding]; metal-binding site 41431003232 UvrB/uvrC motif; Region: UVR; pfam02151 41431003233 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 41431003234 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 41431003235 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 41431003236 recombination protein F; Reviewed; Region: recF; PRK00064 41431003237 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 41431003238 Walker A/P-loop; other site 41431003239 ATP binding site [chemical binding]; other site 41431003240 Q-loop/lid; other site 41431003241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431003242 ABC transporter signature motif; other site 41431003243 Walker B; other site 41431003244 D-loop; other site 41431003245 H-loop/switch region; other site 41431003246 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 41431003247 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 41431003248 tandem repeat interface [polypeptide binding]; other site 41431003249 oligomer interface [polypeptide binding]; other site 41431003250 active site residues [active] 41431003251 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 41431003252 tandem repeat interface [polypeptide binding]; other site 41431003253 oligomer interface [polypeptide binding]; other site 41431003254 active site residues [active] 41431003255 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 41431003256 active site 41431003257 catalytic triad [active] 41431003258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431003259 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431003260 Probable transposase; Region: OrfB_IS605; pfam01385 41431003261 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431003262 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 41431003263 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431003264 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 41431003265 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 41431003266 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 41431003267 active site 41431003268 substrate binding site [chemical binding]; other site 41431003269 cosubstrate binding site; other site 41431003270 catalytic site [active] 41431003271 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 41431003272 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 41431003273 [2Fe-2S] cluster binding site [ion binding]; other site 41431003274 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 41431003275 Transcriptional regulators [Transcription]; Region: MarR; COG1846 41431003276 Protein of unknown function (DUF760); Region: DUF760; pfam05542 41431003277 Probable transposase; Region: OrfB_IS605; pfam01385 41431003278 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431003279 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431003280 Transcriptional regulator [Transcription]; Region: LytR; COG1316 41431003281 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 41431003282 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 41431003283 Cytochrome P450; Region: p450; pfam00067 41431003284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 41431003285 Cupin domain; Region: Cupin_2; cl17218 41431003286 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 41431003287 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 41431003288 catalytic triad [active] 41431003289 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 41431003290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431003291 FeS/SAM binding site; other site 41431003292 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 41431003293 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 41431003294 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 41431003295 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 41431003296 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 41431003297 catalytic site [active] 41431003298 putative active site [active] 41431003299 putative substrate binding site [chemical binding]; other site 41431003300 NifU-like domain; Region: NifU; pfam01106 41431003301 UDP-glucose 4-epimerase; Region: PLN02240 41431003302 hypothetical protein; Provisional; Region: PRK11770 41431003303 Domain of unknown function (DUF307); Region: DUF307; pfam03733 41431003304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 41431003305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431003306 dimer interface [polypeptide binding]; other site 41431003307 conserved gate region; other site 41431003308 ABC-ATPase subunit interface; other site 41431003309 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 41431003310 methionine aminopeptidase; Provisional; Region: PRK08671 41431003311 active site 41431003312 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 41431003313 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 41431003314 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 41431003315 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 41431003316 protein binding site [polypeptide binding]; other site 41431003317 glycogen synthase; Provisional; Region: glgA; PRK00654 41431003318 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 41431003319 ADP-binding pocket [chemical binding]; other site 41431003320 homodimer interface [polypeptide binding]; other site 41431003321 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 41431003322 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 41431003323 catalytic residues [active] 41431003324 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 41431003325 feedback inhibition sensing region; other site 41431003326 homohexameric interface [polypeptide binding]; other site 41431003327 nucleotide binding site [chemical binding]; other site 41431003328 N-acetyl-L-glutamate binding site [chemical binding]; other site 41431003329 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 41431003330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003331 binding surface 41431003332 TPR motif; other site 41431003333 TPR repeat; Region: TPR_11; pfam13414 41431003334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003335 binding surface 41431003336 TPR motif; other site 41431003337 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 41431003338 serine O-acetyltransferase; Region: cysE; TIGR01172 41431003339 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 41431003340 trimer interface [polypeptide binding]; other site 41431003341 active site 41431003342 substrate binding site [chemical binding]; other site 41431003343 CoA binding site [chemical binding]; other site 41431003344 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 41431003345 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 41431003346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003347 TPR repeat; Region: TPR_11; pfam13414 41431003348 binding surface 41431003349 TPR motif; other site 41431003350 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431003351 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 41431003352 substrate binding pocket [chemical binding]; other site 41431003353 membrane-bound complex binding site; other site 41431003354 hinge residues; other site 41431003355 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003357 active site 41431003358 phosphorylation site [posttranslational modification] 41431003359 intermolecular recognition site; other site 41431003360 dimerization interface [polypeptide binding]; other site 41431003361 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431003362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431003363 metal binding site [ion binding]; metal-binding site 41431003364 active site 41431003365 I-site; other site 41431003366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431003367 HAMP domain; Region: HAMP; pfam00672 41431003368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003369 PAS fold; Region: PAS_3; pfam08447 41431003370 putative active site [active] 41431003371 heme pocket [chemical binding]; other site 41431003372 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431003373 dimer interface [polypeptide binding]; other site 41431003374 phosphorylation site [posttranslational modification] 41431003375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003376 ATP binding site [chemical binding]; other site 41431003377 Mg2+ binding site [ion binding]; other site 41431003378 G-X-G motif; other site 41431003379 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003381 active site 41431003382 phosphorylation site [posttranslational modification] 41431003383 intermolecular recognition site; other site 41431003384 dimerization interface [polypeptide binding]; other site 41431003385 Thf1-like protein; Reviewed; Region: PRK13266 41431003386 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 41431003387 aspartate kinase; Provisional; Region: PRK07431 41431003388 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 41431003389 putative catalytic residues [active] 41431003390 putative nucleotide binding site [chemical binding]; other site 41431003391 putative aspartate binding site [chemical binding]; other site 41431003392 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 41431003393 putative allosteric regulatory site; other site 41431003394 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 41431003395 putative allosteric regulatory residue; other site 41431003396 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 41431003397 putative allosteric regulatory site; other site 41431003398 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 41431003399 putative allosteric regulatory residue; other site 41431003400 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 41431003401 Cupin domain; Region: Cupin_2; pfam07883 41431003402 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 41431003403 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 41431003404 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 41431003405 active site 41431003406 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431003407 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431003408 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431003409 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431003410 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 41431003411 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 41431003412 metal-binding site 41431003413 active site 41431003414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431003415 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 41431003416 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 41431003417 putative active site [active] 41431003418 putative metal binding site [ion binding]; other site 41431003419 CAAX protease self-immunity; Region: Abi; pfam02517 41431003420 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 41431003421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431003422 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431003423 Probable transposase; Region: OrfB_IS605; pfam01385 41431003424 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431003425 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 41431003426 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 41431003427 GatB domain; Region: GatB_Yqey; smart00845 41431003428 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 41431003429 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 41431003430 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 41431003431 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431003432 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431003433 ligand binding site [chemical binding]; other site 41431003434 flexible hinge region; other site 41431003435 cobalamin synthase; Reviewed; Region: cobS; PRK00235 41431003436 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 41431003437 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 41431003438 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 41431003439 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 41431003440 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 41431003441 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 41431003442 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 41431003443 amidohydrolase; Region: amidohydrolases; TIGR01891 41431003444 metal binding site [ion binding]; metal-binding site 41431003445 dimer interface [polypeptide binding]; other site 41431003446 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 41431003447 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 41431003448 dimer interface [polypeptide binding]; other site 41431003449 active site 41431003450 recombination protein RecR; Reviewed; Region: recR; PRK00076 41431003451 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 41431003452 RecR protein; Region: RecR; pfam02132 41431003453 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 41431003454 putative active site [active] 41431003455 putative metal-binding site [ion binding]; other site 41431003456 tetramer interface [polypeptide binding]; other site 41431003457 Probable transposase; Region: OrfB_IS605; pfam01385 41431003458 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431003459 Predicted flavoprotein [General function prediction only]; Region: COG0431 41431003460 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 41431003461 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 41431003462 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 41431003463 dimer interface [polypeptide binding]; other site 41431003464 motif 1; other site 41431003465 active site 41431003466 motif 2; other site 41431003467 motif 3; other site 41431003468 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 41431003469 anticodon binding site; other site 41431003470 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003471 putative active site [active] 41431003472 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 41431003473 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 41431003474 N- and C-terminal domain interface [polypeptide binding]; other site 41431003475 active site 41431003476 MgATP binding site [chemical binding]; other site 41431003477 catalytic site [active] 41431003478 metal binding site [ion binding]; metal-binding site 41431003479 glycerol binding site [chemical binding]; other site 41431003480 homotetramer interface [polypeptide binding]; other site 41431003481 homodimer interface [polypeptide binding]; other site 41431003482 FBP binding site [chemical binding]; other site 41431003483 protein IIAGlc interface [polypeptide binding]; other site 41431003484 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 41431003485 CoA binding domain; Region: CoA_binding; smart00881 41431003486 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 41431003487 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 41431003488 ring oligomerisation interface [polypeptide binding]; other site 41431003489 ATP/Mg binding site [chemical binding]; other site 41431003490 stacking interactions; other site 41431003491 hinge regions; other site 41431003492 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 41431003493 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 41431003494 DNA binding residues [nucleotide binding] 41431003495 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 41431003496 catalytic residues [active] 41431003497 catalytic nucleophile [active] 41431003498 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 41431003499 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 41431003500 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 41431003501 nitrilase; Region: PLN02798 41431003502 putative active site [active] 41431003503 catalytic triad [active] 41431003504 dimer interface [polypeptide binding]; other site 41431003505 aspartate aminotransferase; Provisional; Region: PRK05957 41431003506 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431003507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431003508 homodimer interface [polypeptide binding]; other site 41431003509 catalytic residue [active] 41431003510 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 41431003511 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431003512 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003513 putative active site [active] 41431003514 PemK-like protein; Region: PemK; cl00995 41431003515 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 41431003516 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 41431003517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431003518 Walker A motif; other site 41431003519 ATP binding site [chemical binding]; other site 41431003520 Walker B motif; other site 41431003521 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 41431003522 RxxxH motif; other site 41431003523 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 41431003524 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 41431003525 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 41431003526 Coenzyme A binding pocket [chemical binding]; other site 41431003527 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 41431003528 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 41431003529 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 41431003530 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 41431003531 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431003532 catalytic loop [active] 41431003533 iron binding site [ion binding]; other site 41431003534 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 41431003535 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 41431003536 acyl-activating enzyme (AAE) consensus motif; other site 41431003537 putative AMP binding site [chemical binding]; other site 41431003538 putative active site [active] 41431003539 putative CoA binding site [chemical binding]; other site 41431003540 O-succinylbenzoate synthase; Provisional; Region: PRK02714 41431003541 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 41431003542 active site 41431003543 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 41431003544 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 41431003545 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 41431003546 MPT binding site; other site 41431003547 trimer interface [polypeptide binding]; other site 41431003548 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 41431003549 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 41431003550 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 41431003551 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 41431003552 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 41431003553 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 41431003554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431003555 motif II; other site 41431003556 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 41431003557 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 41431003558 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431003559 active site 41431003560 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431003561 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003562 binding surface 41431003563 TPR motif; other site 41431003564 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431003565 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431003566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003567 binding surface 41431003568 TPR motif; other site 41431003569 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431003570 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431003571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003572 binding surface 41431003573 TPR motif; other site 41431003574 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431003575 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 41431003576 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 41431003577 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 41431003578 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 41431003579 Bifunctional nuclease; Region: DNase-RNase; pfam02577 41431003580 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 41431003581 Lumazine binding domain; Region: Lum_binding; pfam00677 41431003582 Lumazine binding domain; Region: Lum_binding; pfam00677 41431003583 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431003584 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 41431003585 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 41431003586 Phycobilisome protein; Region: Phycobilisome; cl08227 41431003587 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 41431003588 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 41431003589 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 41431003590 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 41431003591 catalytic motif [active] 41431003592 Zn binding site [ion binding]; other site 41431003593 RibD C-terminal domain; Region: RibD_C; cl17279 41431003594 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 41431003595 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 41431003596 E3 interaction surface; other site 41431003597 lipoyl attachment site [posttranslational modification]; other site 41431003598 e3 binding domain; Region: E3_binding; pfam02817 41431003599 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 41431003600 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 41431003601 putative active site [active] 41431003602 dimerization interface [polypeptide binding]; other site 41431003603 putative tRNAtyr binding site [nucleotide binding]; other site 41431003604 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 41431003605 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 41431003606 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 41431003607 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003609 active site 41431003610 phosphorylation site [posttranslational modification] 41431003611 intermolecular recognition site; other site 41431003612 dimerization interface [polypeptide binding]; other site 41431003613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003614 NADH(P)-binding; Region: NAD_binding_10; pfam13460 41431003615 NAD(P) binding site [chemical binding]; other site 41431003616 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 41431003617 NADH(P)-binding; Region: NAD_binding_10; pfam13460 41431003618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003619 active site 41431003620 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431003621 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 41431003622 protein I interface; other site 41431003623 D2 interface; other site 41431003624 protein T interface; other site 41431003625 chlorophyll binding site; other site 41431003626 beta carotene binding site; other site 41431003627 pheophytin binding site; other site 41431003628 manganese-stabilizing polypeptide interface; other site 41431003629 CP43 interface; other site 41431003630 protein L interface; other site 41431003631 oxygen evolving complex binding site; other site 41431003632 bromide binding site; other site 41431003633 quinone binding site; other site 41431003634 Fe binding site [ion binding]; other site 41431003635 core light harvesting interface; other site 41431003636 cytochrome b559 alpha subunit interface; other site 41431003637 cytochrome c-550 interface; other site 41431003638 protein J interface; other site 41431003639 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003640 putative active site [active] 41431003641 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 41431003642 catalytic motif [active] 41431003643 Zn binding site [ion binding]; other site 41431003644 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 41431003645 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 41431003646 trimer interface [polypeptide binding]; other site 41431003647 active site 41431003648 Tetrahydromethanopterin S-methyltransferase, subunit A; Region: MtrA; cl04449 41431003649 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 41431003650 dimerization interface [polypeptide binding]; other site 41431003651 active site 41431003652 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 41431003653 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431003654 Predicted permease [General function prediction only]; Region: COG3329 41431003655 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 41431003656 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 41431003657 TMP-binding site; other site 41431003658 ATP-binding site [chemical binding]; other site 41431003659 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 41431003660 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 41431003661 iron-sulfur cluster [ion binding]; other site 41431003662 [2Fe-2S] cluster binding site [ion binding]; other site 41431003663 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003664 putative active site [active] 41431003665 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431003666 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431003667 P-loop; other site 41431003668 Magnesium ion binding site [ion binding]; other site 41431003669 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431003670 Magnesium ion binding site [ion binding]; other site 41431003671 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 41431003672 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 41431003673 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 41431003674 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 41431003675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 41431003676 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 41431003677 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 41431003678 YCII-related domain; Region: YCII; cl00999 41431003679 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431003680 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431003681 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431003682 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431003683 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 41431003684 cyclase homology domain; Region: CHD; cd07302 41431003685 nucleotidyl binding site; other site 41431003686 metal binding site [ion binding]; metal-binding site 41431003687 dimer interface [polypeptide binding]; other site 41431003688 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 41431003689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431003690 Coenzyme A binding pocket [chemical binding]; other site 41431003691 TPR repeat; Region: TPR_11; pfam13414 41431003692 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 41431003693 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 41431003694 putative ligand binding site [chemical binding]; other site 41431003695 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 41431003696 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 41431003697 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 41431003698 Walker A motif; other site 41431003699 ATP binding site [chemical binding]; other site 41431003700 Walker B motif; other site 41431003701 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 41431003702 lipoyl attachment site [posttranslational modification]; other site 41431003703 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003704 putative active site [active] 41431003705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003706 PAS fold; Region: PAS_3; pfam08447 41431003707 putative active site [active] 41431003708 heme pocket [chemical binding]; other site 41431003709 PAS fold; Region: PAS_4; pfam08448 41431003710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003711 putative active site [active] 41431003712 heme pocket [chemical binding]; other site 41431003713 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431003714 GAF domain; Region: GAF; pfam01590 41431003715 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 41431003716 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003717 putative active site [active] 41431003718 heme pocket [chemical binding]; other site 41431003719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431003720 dimer interface [polypeptide binding]; other site 41431003721 phosphorylation site [posttranslational modification] 41431003722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003723 ATP binding site [chemical binding]; other site 41431003724 Mg2+ binding site [ion binding]; other site 41431003725 G-X-G motif; other site 41431003726 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003728 active site 41431003729 phosphorylation site [posttranslational modification] 41431003730 intermolecular recognition site; other site 41431003731 dimerization interface [polypeptide binding]; other site 41431003732 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 41431003733 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 41431003734 putative acyl-acceptor binding pocket; other site 41431003735 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 41431003736 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431003737 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431003738 Magnesium ion binding site [ion binding]; other site 41431003739 photosystem I subunit VII; Region: psaC; CHL00065 41431003740 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 41431003741 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 41431003742 DHH family; Region: DHH; pfam01368 41431003743 DHHA1 domain; Region: DHHA1; pfam02272 41431003744 AAA domain; Region: AAA_23; pfam13476 41431003745 AAA domain; Region: AAA_21; pfam13304 41431003746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431003747 Walker B; other site 41431003748 D-loop; other site 41431003749 H-loop/switch region; other site 41431003750 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 41431003751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003752 Mg2+ binding site [ion binding]; other site 41431003753 G-X-G motif; other site 41431003754 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 41431003755 anchoring element; other site 41431003756 dimer interface [polypeptide binding]; other site 41431003757 ATP binding site [chemical binding]; other site 41431003758 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 41431003759 active site 41431003760 putative metal-binding site [ion binding]; other site 41431003761 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 41431003762 stage V sporulation protein K; Region: spore_V_K; TIGR02881 41431003763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431003764 Walker A motif; other site 41431003765 ATP binding site [chemical binding]; other site 41431003766 Walker B motif; other site 41431003767 arginine finger; other site 41431003768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 41431003769 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 41431003770 O-Antigen ligase; Region: Wzy_C; pfam04932 41431003771 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 41431003772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431003773 ATP binding site [chemical binding]; other site 41431003774 putative Mg++ binding site [ion binding]; other site 41431003775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431003776 nucleotide binding region [chemical binding]; other site 41431003777 ATP-binding site [chemical binding]; other site 41431003778 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 41431003779 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 41431003780 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 41431003781 RNA binding site [nucleotide binding]; other site 41431003782 active site 41431003783 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 41431003784 Protein of unknown function (DUF98); Region: DUF98; pfam01947 41431003785 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 41431003786 DHH family; Region: DHH; pfam01368 41431003787 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 41431003788 RNA methyltransferase, RsmE family; Region: TIGR00046 41431003789 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 41431003790 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 41431003791 Protein of unknown function (DUF433); Region: DUF433; pfam04255 41431003792 TPR repeat; Region: TPR_11; pfam13414 41431003793 TPR repeat; Region: TPR_11; pfam13414 41431003794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003795 binding surface 41431003796 TPR motif; other site 41431003797 TPR repeat; Region: TPR_11; pfam13414 41431003798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003799 binding surface 41431003800 TPR motif; other site 41431003801 TPR repeat; Region: TPR_11; pfam13414 41431003802 Tetratricopeptide repeat; Region: TPR_16; pfam13432 41431003803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003804 TPR motif; other site 41431003805 TPR repeat; Region: TPR_11; pfam13414 41431003806 binding surface 41431003807 TPR repeat; Region: TPR_11; pfam13414 41431003808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003809 binding surface 41431003810 TPR motif; other site 41431003811 TPR repeat; Region: TPR_11; pfam13414 41431003812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003813 binding surface 41431003814 TPR motif; other site 41431003815 TPR repeat; Region: TPR_11; pfam13414 41431003816 TPR repeat; Region: TPR_11; pfam13414 41431003817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003818 binding surface 41431003819 TPR motif; other site 41431003820 TPR repeat; Region: TPR_11; pfam13414 41431003821 TPR repeat; Region: TPR_11; pfam13414 41431003822 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431003823 binding surface 41431003824 TPR motif; other site 41431003825 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 41431003826 Conserved TM helix; Region: TM_helix; pfam05552 41431003827 Conserved TM helix; Region: TM_helix; pfam05552 41431003828 Conserved TM helix; Region: TM_helix; pfam05552 41431003829 adaptive-response sensory kinase; Validated; Region: PRK09303 41431003830 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 41431003831 tetramer interface [polypeptide binding]; other site 41431003832 dimer interface [polypeptide binding]; other site 41431003833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431003834 dimer interface [polypeptide binding]; other site 41431003835 phosphorylation site [posttranslational modification] 41431003836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003837 ATP binding site [chemical binding]; other site 41431003838 Mg2+ binding site [ion binding]; other site 41431003839 G-X-G motif; other site 41431003840 Uncharacterized conserved protein [Function unknown]; Region: COG1543 41431003841 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 41431003842 active site 41431003843 substrate binding site [chemical binding]; other site 41431003844 catalytic site [active] 41431003845 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 41431003846 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 41431003847 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 41431003848 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 41431003849 iron-sulfur cluster [ion binding]; other site 41431003850 [2Fe-2S] cluster binding site [ion binding]; other site 41431003851 carotene isomerase; Region: carot_isom; TIGR02730 41431003852 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 41431003853 hydroxyglutarate oxidase; Provisional; Region: PRK11728 41431003854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431003855 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 41431003856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003857 ATP binding site [chemical binding]; other site 41431003858 Mg2+ binding site [ion binding]; other site 41431003859 G-X-G motif; other site 41431003860 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 41431003861 ABC1 family; Region: ABC1; cl17513 41431003862 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431003863 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 41431003864 precorrin-8X methylmutase; Validated; Region: PRK05953 41431003865 Precorrin-8X methylmutase; Region: CbiC; pfam02570 41431003866 Repair protein; Region: Repair_PSII; pfam04536 41431003867 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 41431003868 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 41431003869 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 41431003870 purine monophosphate binding site [chemical binding]; other site 41431003871 dimer interface [polypeptide binding]; other site 41431003872 putative catalytic residues [active] 41431003873 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 41431003874 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 41431003875 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003876 putative active site [active] 41431003877 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 41431003878 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 41431003879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003880 NAD(P) binding site [chemical binding]; other site 41431003881 active site 41431003882 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431003883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431003884 NAD(P) binding site [chemical binding]; other site 41431003885 active site 41431003886 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431003887 putative active site [active] 41431003888 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 41431003889 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 41431003890 G1 box; other site 41431003891 GTP/Mg2+ binding site [chemical binding]; other site 41431003892 Switch I region; other site 41431003893 G2 box; other site 41431003894 Switch II region; other site 41431003895 G3 box; other site 41431003896 G4 box; other site 41431003897 G5 box; other site 41431003898 Domain of unknown function (DUF697); Region: DUF697; pfam05128 41431003899 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 41431003900 RNA/DNA hybrid binding site [nucleotide binding]; other site 41431003901 active site 41431003902 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 41431003903 DNA-binding site [nucleotide binding]; DNA binding site 41431003904 RNA-binding motif; other site 41431003905 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 41431003906 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 41431003907 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 41431003908 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 41431003909 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431003910 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431003911 active site 41431003912 ATP binding site [chemical binding]; other site 41431003913 substrate binding site [chemical binding]; other site 41431003914 activation loop (A-loop); other site 41431003915 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 41431003916 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 41431003917 Zn binding site [ion binding]; other site 41431003918 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 41431003919 elongation factor G; Reviewed; Region: PRK12740 41431003920 G1 box; other site 41431003921 putative GEF interaction site [polypeptide binding]; other site 41431003922 GTP/Mg2+ binding site [chemical binding]; other site 41431003923 Switch I region; other site 41431003924 G2 box; other site 41431003925 G3 box; other site 41431003926 Switch II region; other site 41431003927 G4 box; other site 41431003928 G5 box; other site 41431003929 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 41431003930 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 41431003931 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 41431003932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431003933 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431003934 Probable transposase; Region: OrfB_IS605; pfam01385 41431003935 Transposase IS200 like; Region: Y1_Tnp; pfam01797 41431003936 Transglycosylase; Region: Transgly; pfam00912 41431003937 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 41431003938 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 41431003939 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 41431003940 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 41431003941 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 41431003942 active site 41431003943 Zn binding site [ion binding]; other site 41431003944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431003945 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431003946 Probable transposase; Region: OrfB_IS605; pfam01385 41431003947 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431003948 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431003949 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431003950 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 41431003951 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431003952 phosphopeptide binding site; other site 41431003953 PAS domain S-box; Region: sensory_box; TIGR00229 41431003954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003955 putative active site [active] 41431003956 heme pocket [chemical binding]; other site 41431003957 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431003958 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431003959 metal binding site [ion binding]; metal-binding site 41431003960 active site 41431003961 I-site; other site 41431003962 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431003963 PAS fold; Region: PAS_3; pfam08447 41431003964 PAS domain S-box; Region: sensory_box; TIGR00229 41431003965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003966 putative active site [active] 41431003967 heme pocket [chemical binding]; other site 41431003968 hypothetical protein; Provisional; Region: PRK13560 41431003969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003970 putative active site [active] 41431003971 heme pocket [chemical binding]; other site 41431003972 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003973 putative active site [active] 41431003974 heme pocket [chemical binding]; other site 41431003975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003976 putative active site [active] 41431003977 heme pocket [chemical binding]; other site 41431003978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431003979 putative active site [active] 41431003980 heme pocket [chemical binding]; other site 41431003981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431003982 dimer interface [polypeptide binding]; other site 41431003983 phosphorylation site [posttranslational modification] 41431003984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431003985 ATP binding site [chemical binding]; other site 41431003986 Mg2+ binding site [ion binding]; other site 41431003987 G-X-G motif; other site 41431003988 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003990 active site 41431003991 phosphorylation site [posttranslational modification] 41431003992 intermolecular recognition site; other site 41431003993 dimerization interface [polypeptide binding]; other site 41431003994 Response regulator receiver domain; Region: Response_reg; pfam00072 41431003995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431003996 active site 41431003997 phosphorylation site [posttranslational modification] 41431003998 intermolecular recognition site; other site 41431003999 dimerization interface [polypeptide binding]; other site 41431004000 PAS fold; Region: PAS_4; pfam08448 41431004001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431004002 putative active site [active] 41431004003 heme pocket [chemical binding]; other site 41431004004 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431004005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431004006 metal binding site [ion binding]; metal-binding site 41431004007 active site 41431004008 I-site; other site 41431004009 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431004010 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 41431004011 pseudouridine synthase; Region: TIGR00093 41431004012 active site 41431004013 CpeS-like protein; Region: CpeS; pfam09367 41431004014 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431004015 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 41431004016 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 41431004017 dimer interface [polypeptide binding]; other site 41431004018 motif 1; other site 41431004019 active site 41431004020 motif 2; other site 41431004021 motif 3; other site 41431004022 O-Antigen ligase; Region: Wzy_C; pfam04932 41431004023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004024 binding surface 41431004025 TPR motif; other site 41431004026 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 41431004027 Cytochrome P450; Region: p450; cl12078 41431004028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 41431004029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431004030 Coenzyme A binding pocket [chemical binding]; other site 41431004031 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 41431004032 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 41431004033 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 41431004034 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 41431004035 CAP-like domain; other site 41431004036 active site 41431004037 primary dimer interface [polypeptide binding]; other site 41431004038 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431004039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 41431004040 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431004041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004042 active site 41431004043 phosphorylation site [posttranslational modification] 41431004044 intermolecular recognition site; other site 41431004045 dimerization interface [polypeptide binding]; other site 41431004046 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 41431004047 Stage II sporulation protein; Region: SpoIID; pfam08486 41431004048 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431004049 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431004050 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 41431004051 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 41431004052 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 41431004053 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 41431004054 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 41431004055 active site 41431004056 dimerization interface [polypeptide binding]; other site 41431004057 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 41431004058 MltA specific insert domain; Region: MltA; pfam03562 41431004059 3D domain; Region: 3D; pfam06725 41431004060 MoxR-like ATPases [General function prediction only]; Region: COG0714 41431004061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431004062 Walker A motif; other site 41431004063 ATP binding site [chemical binding]; other site 41431004064 Walker B motif; other site 41431004065 arginine finger; other site 41431004066 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 41431004067 Dihaem cytochrome c; Region: DHC; pfam09626 41431004068 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 41431004069 Amidase; Region: Amidase; pfam01425 41431004070 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004071 putative active site [active] 41431004072 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 41431004073 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 41431004074 putative active site [active] 41431004075 catalytic triad [active] 41431004076 putative dimer interface [polypeptide binding]; other site 41431004077 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 41431004078 catalytic core [active] 41431004079 citrate synthase; Provisional; Region: PRK14036 41431004080 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 41431004081 dimer interface [polypeptide binding]; other site 41431004082 active site 41431004083 citrylCoA binding site [chemical binding]; other site 41431004084 oxalacetate/citrate binding site [chemical binding]; other site 41431004085 coenzyme A binding site [chemical binding]; other site 41431004086 catalytic triad [active] 41431004087 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431004088 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 41431004089 heme binding pocket [chemical binding]; other site 41431004090 heme ligand [chemical binding]; other site 41431004091 HEAT repeats; Region: HEAT_2; pfam13646 41431004092 HEAT repeats; Region: HEAT_2; pfam13646 41431004093 CpeS-like protein; Region: CpeS; pfam09367 41431004094 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 41431004095 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431004096 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004097 putative active site [active] 41431004098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431004099 S-adenosylmethionine binding site [chemical binding]; other site 41431004100 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 41431004101 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 41431004102 putative C-terminal domain interface [polypeptide binding]; other site 41431004103 putative GSH binding site (G-site) [chemical binding]; other site 41431004104 putative dimer interface [polypeptide binding]; other site 41431004105 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 41431004106 N-terminal domain interface [polypeptide binding]; other site 41431004107 dimer interface [polypeptide binding]; other site 41431004108 substrate binding pocket (H-site) [chemical binding]; other site 41431004109 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 41431004110 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 41431004111 catalytic residues [active] 41431004112 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 41431004113 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004114 putative active site [active] 41431004115 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 41431004116 Domain of unknown function (DUF364); Region: DUF364; pfam04016 41431004117 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 41431004118 Haemolysin XhlA; Region: XhlA; pfam10779 41431004119 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 41431004120 Peptidase family M23; Region: Peptidase_M23; pfam01551 41431004121 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 41431004122 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 41431004123 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 41431004124 catalytic site [active] 41431004125 active site 41431004126 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 41431004127 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 41431004128 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 41431004129 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 41431004130 active site 41431004131 catalytic site [active] 41431004132 Trehalase; Region: Trehalase; cl17346 41431004133 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 41431004134 Predicted membrane protein [Function unknown]; Region: COG3431 41431004135 putative transposase; Provisional; Region: PHA02942 41431004136 Probable transposase; Region: OrfB_IS605; pfam01385 41431004137 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431004138 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 41431004139 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 41431004140 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 41431004141 putative active site [active] 41431004142 putative NTP binding site [chemical binding]; other site 41431004143 putative nucleic acid binding site [nucleotide binding]; other site 41431004144 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 41431004145 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 41431004146 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431004147 active site 41431004148 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 41431004149 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 41431004150 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 41431004151 putative active site [active] 41431004152 putative NTP binding site [chemical binding]; other site 41431004153 putative nucleic acid binding site [nucleotide binding]; other site 41431004154 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 41431004155 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 41431004156 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431004157 active site 41431004158 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 41431004159 Cytomegalovirus IE1 protein; Region: Herpes_IE1; pfam07340 41431004160 Dynamin family; Region: Dynamin_N; pfam00350 41431004161 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 41431004162 G1 box; other site 41431004163 GTP/Mg2+ binding site [chemical binding]; other site 41431004164 Switch I region; other site 41431004165 G2 box; other site 41431004166 Switch II region; other site 41431004167 G3 box; other site 41431004168 G4 box; other site 41431004169 G5 box; other site 41431004170 Domain of unknown function (DUF697); Region: DUF697; pfam05128 41431004171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 41431004172 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 41431004173 Domain of unknown function (DUF389); Region: DUF389; pfam04087 41431004174 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 41431004175 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 41431004176 active site 41431004177 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 41431004178 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 41431004179 Putative restriction endonuclease; Region: Uma2; pfam05685 41431004180 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 41431004181 FAD binding domain; Region: FAD_binding_4; pfam01565 41431004182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431004183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004184 dimer interface [polypeptide binding]; other site 41431004185 phosphorylation site [posttranslational modification] 41431004186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004187 ATP binding site [chemical binding]; other site 41431004188 Mg2+ binding site [ion binding]; other site 41431004189 G-X-G motif; other site 41431004190 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431004191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004192 active site 41431004193 phosphorylation site [posttranslational modification] 41431004194 intermolecular recognition site; other site 41431004195 dimerization interface [polypeptide binding]; other site 41431004196 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431004197 DNA binding site [nucleotide binding] 41431004198 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 41431004199 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 41431004200 Clp protease ATP binding subunit; Region: clpC; CHL00095 41431004201 Clp amino terminal domain; Region: Clp_N; pfam02861 41431004202 Clp amino terminal domain; Region: Clp_N; pfam02861 41431004203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431004204 Walker A motif; other site 41431004205 ATP binding site [chemical binding]; other site 41431004206 Walker B motif; other site 41431004207 arginine finger; other site 41431004208 UvrB/uvrC motif; Region: UVR; pfam02151 41431004209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431004210 Walker A motif; other site 41431004211 ATP binding site [chemical binding]; other site 41431004212 Walker B motif; other site 41431004213 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 41431004214 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 41431004215 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 41431004216 motif 1; other site 41431004217 active site 41431004218 motif 2; other site 41431004219 motif 3; other site 41431004220 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 41431004221 putative acyl transferase; Provisional; Region: PRK10502 41431004222 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 41431004223 putative trimer interface [polypeptide binding]; other site 41431004224 putative active site [active] 41431004225 putative substrate binding site [chemical binding]; other site 41431004226 putative CoA binding site [chemical binding]; other site 41431004227 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 41431004228 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431004229 putative metal binding site; other site 41431004230 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 41431004231 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 41431004232 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 41431004233 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 41431004234 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 41431004235 putative active site [active] 41431004236 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 41431004237 TIR domain; Region: TIR_2; pfam13676 41431004238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431004239 PAS fold; Region: PAS_3; pfam08447 41431004240 putative active site [active] 41431004241 heme pocket [chemical binding]; other site 41431004242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431004243 PAS fold; Region: PAS_3; pfam08447 41431004244 putative active site [active] 41431004245 heme pocket [chemical binding]; other site 41431004246 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431004247 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431004248 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431004249 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431004250 metal binding site [ion binding]; metal-binding site 41431004251 active site 41431004252 I-site; other site 41431004253 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 41431004254 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 41431004255 Zn2+ binding site [ion binding]; other site 41431004256 Mg2+ binding site [ion binding]; other site 41431004257 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 41431004258 synthetase active site [active] 41431004259 NTP binding site [chemical binding]; other site 41431004260 metal binding site [ion binding]; metal-binding site 41431004261 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 41431004262 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 41431004263 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 41431004264 glutaminase; Provisional; Region: PRK00971 41431004265 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 41431004266 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 41431004267 HAMP domain; Region: HAMP; pfam00672 41431004268 dimerization interface [polypeptide binding]; other site 41431004269 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 41431004270 dimer interface [polypeptide binding]; other site 41431004271 putative CheW interface [polypeptide binding]; other site 41431004272 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 41431004273 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 41431004274 Tetratricopeptide repeat; Region: TPR_16; pfam13432 41431004275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004276 TPR motif; other site 41431004277 binding surface 41431004278 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 41431004279 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 41431004280 catalytic center binding site [active] 41431004281 ATP binding site [chemical binding]; other site 41431004282 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 41431004283 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 41431004284 dimer interface [polypeptide binding]; other site 41431004285 ADP-ribose binding site [chemical binding]; other site 41431004286 active site 41431004287 nudix motif; other site 41431004288 metal binding site [ion binding]; metal-binding site 41431004289 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 41431004290 DNA photolyase; Region: DNA_photolyase; pfam00875 41431004291 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 41431004292 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431004293 FeS/SAM binding site; other site 41431004294 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 41431004295 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 41431004296 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 41431004297 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 41431004298 S-layer homology domain; Region: SLH; pfam00395 41431004299 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 41431004300 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 41431004301 FeoA domain; Region: FeoA; pfam04023 41431004302 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 41431004303 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 41431004304 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 41431004305 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 41431004306 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 41431004307 putative NAD(P) binding site [chemical binding]; other site 41431004308 putative substrate binding site [chemical binding]; other site 41431004309 catalytic Zn binding site [ion binding]; other site 41431004310 structural Zn binding site [ion binding]; other site 41431004311 dimer interface [polypeptide binding]; other site 41431004312 Predicted integral membrane protein [Function unknown]; Region: COG5542 41431004313 Predicted membrane protein [Function unknown]; Region: COG3463 41431004314 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 41431004315 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 41431004316 putative RNA binding site [nucleotide binding]; other site 41431004317 Uncharacterized conserved protein [Function unknown]; Region: COG2928 41431004318 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 41431004319 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 41431004320 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 41431004321 putative active site [active] 41431004322 Double zinc ribbon; Region: DZR; pfam12773 41431004323 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 41431004324 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 41431004325 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431004326 phosphopeptide binding site; other site 41431004327 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 41431004328 Peptidase family M50; Region: Peptidase_M50; pfam02163 41431004329 active site 41431004330 putative substrate binding region [chemical binding]; other site 41431004331 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 41431004332 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 41431004333 classical (c) SDRs; Region: SDR_c; cd05233 41431004334 NAD(P) binding site [chemical binding]; other site 41431004335 active site 41431004336 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 41431004337 Predicted ATPase [General function prediction only]; Region: COG4637 41431004338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431004339 Walker A/P-loop; other site 41431004340 ATP binding site [chemical binding]; other site 41431004341 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 41431004342 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 41431004343 Walker A/P-loop; other site 41431004344 ATP binding site [chemical binding]; other site 41431004345 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 41431004346 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 41431004347 ABC transporter signature motif; other site 41431004348 Walker B; other site 41431004349 D-loop; other site 41431004350 H-loop/switch region; other site 41431004351 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 41431004352 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431004353 substrate binding pocket [chemical binding]; other site 41431004354 membrane-bound complex binding site; other site 41431004355 hinge residues; other site 41431004356 rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260 41431004357 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 41431004358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431004359 FeS/SAM binding site; other site 41431004360 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 41431004361 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431004362 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 41431004363 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 41431004364 active site 41431004365 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 41431004366 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 41431004367 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431004368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431004369 homodimer interface [polypeptide binding]; other site 41431004370 catalytic residue [active] 41431004371 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 41431004372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 41431004373 non-specific DNA binding site [nucleotide binding]; other site 41431004374 salt bridge; other site 41431004375 sequence-specific DNA binding site [nucleotide binding]; other site 41431004376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 41431004377 Walker A motif; other site 41431004378 ATP binding site [chemical binding]; other site 41431004379 Walker B motif; other site 41431004380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431004381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004382 dimer interface [polypeptide binding]; other site 41431004383 phosphorylation site [posttranslational modification] 41431004384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004385 ATP binding site [chemical binding]; other site 41431004386 Mg2+ binding site [ion binding]; other site 41431004387 G-X-G motif; other site 41431004388 Response regulator receiver domain; Region: Response_reg; pfam00072 41431004389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004390 active site 41431004391 phosphorylation site [posttranslational modification] 41431004392 intermolecular recognition site; other site 41431004393 dimerization interface [polypeptide binding]; other site 41431004394 Response regulator receiver domain; Region: Response_reg; pfam00072 41431004395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004396 active site 41431004397 phosphorylation site [posttranslational modification] 41431004398 intermolecular recognition site; other site 41431004399 dimerization interface [polypeptide binding]; other site 41431004400 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431004401 putative binding surface; other site 41431004402 active site 41431004403 Response regulator receiver domain; Region: Response_reg; pfam00072 41431004404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004405 active site 41431004406 phosphorylation site [posttranslational modification] 41431004407 intermolecular recognition site; other site 41431004408 dimerization interface [polypeptide binding]; other site 41431004409 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431004410 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431004411 Predicted integral membrane protein [Function unknown]; Region: COG0392 41431004412 precorrin-8X methylmutase; Provisional; Region: PRK05954 41431004413 Precorrin-8X methylmutase; Region: CbiC; pfam02570 41431004414 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 41431004415 putative homodimer interface [polypeptide binding]; other site 41431004416 active site 41431004417 SAM binding site [chemical binding]; other site 41431004418 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 41431004419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431004420 S-adenosylmethionine binding site [chemical binding]; other site 41431004421 Predicted permease; Region: DUF318; pfam03773 41431004422 TIGR03943 family protein; Region: TIGR03943 41431004423 Bacterial Ig-like domain; Region: Big_5; pfam13205 41431004424 Response regulator receiver domain; Region: Response_reg; pfam00072 41431004425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004426 active site 41431004427 phosphorylation site [posttranslational modification] 41431004428 intermolecular recognition site; other site 41431004429 dimerization interface [polypeptide binding]; other site 41431004430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004431 dimer interface [polypeptide binding]; other site 41431004432 phosphorylation site [posttranslational modification] 41431004433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004434 ATP binding site [chemical binding]; other site 41431004435 Mg2+ binding site [ion binding]; other site 41431004436 G-X-G motif; other site 41431004437 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 41431004438 GAF domain; Region: GAF; pfam01590 41431004439 Phytochrome region; Region: PHY; pfam00360 41431004440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004441 dimer interface [polypeptide binding]; other site 41431004442 phosphorylation site [posttranslational modification] 41431004443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004444 ATP binding site [chemical binding]; other site 41431004445 Mg2+ binding site [ion binding]; other site 41431004446 G-X-G motif; other site 41431004447 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431004448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004449 active site 41431004450 phosphorylation site [posttranslational modification] 41431004451 intermolecular recognition site; other site 41431004452 dimerization interface [polypeptide binding]; other site 41431004453 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 41431004454 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431004455 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431004456 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 41431004457 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 41431004458 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 41431004459 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 41431004460 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 41431004461 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 41431004462 substrate binding site [chemical binding]; other site 41431004463 active site 41431004464 catalytic residues [active] 41431004465 heterodimer interface [polypeptide binding]; other site 41431004466 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 41431004467 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 41431004468 dimer interface [polypeptide binding]; other site 41431004469 decamer (pentamer of dimers) interface [polypeptide binding]; other site 41431004470 catalytic triad [active] 41431004471 peroxidatic and resolving cysteines [active] 41431004472 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 41431004473 active site 41431004474 putative DNA-binding cleft [nucleotide binding]; other site 41431004475 dimer interface [polypeptide binding]; other site 41431004476 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431004477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004478 active site 41431004479 phosphorylation site [posttranslational modification] 41431004480 intermolecular recognition site; other site 41431004481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431004482 dimerization interface [polypeptide binding]; other site 41431004483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004484 dimer interface [polypeptide binding]; other site 41431004485 phosphorylation site [posttranslational modification] 41431004486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004487 ATP binding site [chemical binding]; other site 41431004488 G-X-G motif; other site 41431004489 Cupin domain; Region: Cupin_2; cl17218 41431004490 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 41431004491 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 41431004492 generic binding surface II; other site 41431004493 ssDNA binding site; other site 41431004494 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431004495 ATP binding site [chemical binding]; other site 41431004496 putative Mg++ binding site [ion binding]; other site 41431004497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431004498 nucleotide binding region [chemical binding]; other site 41431004499 ATP-binding site [chemical binding]; other site 41431004500 Methyltransferase domain; Region: Methyltransf_23; pfam13489 41431004501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431004502 S-adenosylmethionine binding site [chemical binding]; other site 41431004503 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 41431004504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431004505 S-adenosylmethionine binding site [chemical binding]; other site 41431004506 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004507 putative active site [active] 41431004508 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 41431004509 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 41431004510 putative active site [active] 41431004511 oxyanion strand; other site 41431004512 catalytic triad [active] 41431004513 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 41431004514 putative substrate binding pocket [chemical binding]; other site 41431004515 catalytic triad [active] 41431004516 AB domain interface; other site 41431004517 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 41431004518 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 41431004519 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431004520 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 41431004521 Chain length determinant protein; Region: Wzz; cl15801 41431004522 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 41431004523 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 41431004524 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 41431004525 SLBB domain; Region: SLBB; pfam10531 41431004526 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 41431004527 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 41431004528 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 41431004529 Rubrerythrin [Energy production and conversion]; Region: COG1592 41431004530 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 41431004531 binuclear metal center [ion binding]; other site 41431004532 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 41431004533 iron binding site [ion binding]; other site 41431004534 YcfA-like protein; Region: YcfA; pfam07927 41431004535 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431004536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431004537 AAA domain; Region: AAA_21; pfam13304 41431004538 Walker A/P-loop; other site 41431004539 ATP binding site [chemical binding]; other site 41431004540 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431004541 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 41431004542 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 41431004543 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 41431004544 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 41431004545 trimer interface [polypeptide binding]; other site 41431004546 active site 41431004547 UDP-GlcNAc binding site [chemical binding]; other site 41431004548 lipid binding site [chemical binding]; lipid-binding site 41431004549 Exoribonuclease R [Transcription]; Region: VacB; COG0557 41431004550 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 41431004551 RNB domain; Region: RNB; pfam00773 41431004552 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 41431004553 RNA binding site [nucleotide binding]; other site 41431004554 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 41431004555 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 41431004556 chorismate binding enzyme; Region: Chorismate_bind; cl10555 41431004557 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 41431004558 UbiA prenyltransferase family; Region: UbiA; pfam01040 41431004559 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 41431004560 Domain of unknown function (DUF309); Region: DUF309; pfam03745 41431004561 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 41431004562 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 41431004563 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431004564 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 41431004565 NAD(P) binding site [chemical binding]; other site 41431004566 catalytic residues [active] 41431004567 Probable transposase; Region: OrfB_IS605; pfam01385 41431004568 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431004569 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431004570 Transposase IS200 like; Region: Y1_Tnp; pfam01797 41431004571 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 41431004572 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 41431004573 iron-sulfur cluster [ion binding]; other site 41431004574 [2Fe-2S] cluster binding site [ion binding]; other site 41431004575 Pheophorbide a oxygenase; Region: PaO; pfam08417 41431004576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 41431004577 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 41431004578 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 41431004579 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 41431004580 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 41431004581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431004582 ATP binding site [chemical binding]; other site 41431004583 putative Mg++ binding site [ion binding]; other site 41431004584 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431004585 nucleotide binding region [chemical binding]; other site 41431004586 ATP-binding site [chemical binding]; other site 41431004587 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 41431004588 homotrimer interaction site [polypeptide binding]; other site 41431004589 putative active site [active] 41431004590 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 41431004591 DNA protecting protein DprA; Region: dprA; TIGR00732 41431004592 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 41431004593 elongation factor Tu; Region: tufA; CHL00071 41431004594 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 41431004595 G1 box; other site 41431004596 GEF interaction site [polypeptide binding]; other site 41431004597 GTP/Mg2+ binding site [chemical binding]; other site 41431004598 Switch I region; other site 41431004599 G2 box; other site 41431004600 G3 box; other site 41431004601 Switch II region; other site 41431004602 G4 box; other site 41431004603 G5 box; other site 41431004604 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 41431004605 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 41431004606 Antibiotic Binding Site [chemical binding]; other site 41431004607 elongation factor G; Reviewed; Region: PRK00007 41431004608 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 41431004609 G1 box; other site 41431004610 putative GEF interaction site [polypeptide binding]; other site 41431004611 GTP/Mg2+ binding site [chemical binding]; other site 41431004612 Switch I region; other site 41431004613 G2 box; other site 41431004614 G3 box; other site 41431004615 Switch II region; other site 41431004616 G4 box; other site 41431004617 G5 box; other site 41431004618 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 41431004619 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 41431004620 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 41431004621 30S ribosomal protein S7; Validated; Region: PRK05302 41431004622 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 41431004623 S17 interaction site [polypeptide binding]; other site 41431004624 S8 interaction site; other site 41431004625 16S rRNA interaction site [nucleotide binding]; other site 41431004626 streptomycin interaction site [chemical binding]; other site 41431004627 23S rRNA interaction site [nucleotide binding]; other site 41431004628 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 41431004629 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 41431004630 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 41431004631 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 41431004632 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 41431004633 catalytic residue [active] 41431004634 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431004635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004636 active site 41431004637 phosphorylation site [posttranslational modification] 41431004638 intermolecular recognition site; other site 41431004639 dimerization interface [polypeptide binding]; other site 41431004640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431004641 DNA binding site [nucleotide binding] 41431004642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004643 dimer interface [polypeptide binding]; other site 41431004644 phosphorylation site [posttranslational modification] 41431004645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004646 ATP binding site [chemical binding]; other site 41431004647 Mg2+ binding site [ion binding]; other site 41431004648 G-X-G motif; other site 41431004649 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 41431004650 homotrimer interface [polypeptide binding]; other site 41431004651 Walker A motif; other site 41431004652 GTP binding site [chemical binding]; other site 41431004653 Walker B motif; other site 41431004654 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 41431004655 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 41431004656 putative active site [active] 41431004657 substrate binding site [chemical binding]; other site 41431004658 putative cosubstrate binding site; other site 41431004659 catalytic site [active] 41431004660 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 41431004661 substrate binding site [chemical binding]; other site 41431004662 DNA polymerase III subunit delta'; Validated; Region: PRK07399 41431004663 DNA polymerase III subunit delta'; Validated; Region: PRK08485 41431004664 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 41431004665 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431004666 phosphopeptide binding site; other site 41431004667 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431004668 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 41431004669 active site 41431004670 metal binding site [ion binding]; metal-binding site 41431004671 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 41431004672 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 41431004673 metal-binding site [ion binding] 41431004674 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 41431004675 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431004676 active site 41431004677 motif I; other site 41431004678 motif II; other site 41431004679 Methyltransferase domain; Region: Methyltransf_23; pfam13489 41431004680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 41431004681 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 41431004682 Peptidase family M23; Region: Peptidase_M23; pfam01551 41431004683 Helix-turn-helix domain; Region: HTH_25; pfam13413 41431004684 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 41431004685 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 41431004686 RNA binding surface [nucleotide binding]; other site 41431004687 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 41431004688 active site 41431004689 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 41431004690 dimer interface [polypeptide binding]; other site 41431004691 active site 41431004692 Schiff base residues; other site 41431004693 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431004694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004695 binding surface 41431004696 TPR motif; other site 41431004697 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431004698 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431004699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004700 binding surface 41431004701 TPR motif; other site 41431004702 TPR repeat; Region: TPR_11; pfam13414 41431004703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004704 TPR motif; other site 41431004705 binding surface 41431004706 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431004707 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431004708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004709 binding surface 41431004710 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431004711 TPR motif; other site 41431004712 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431004713 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004714 TPR motif; other site 41431004715 binding surface 41431004716 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431004717 CHAT domain; Region: CHAT; pfam12770 41431004718 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431004719 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431004720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431004721 binding surface 41431004722 TPR motif; other site 41431004723 TPR repeat; Region: TPR_11; pfam13414 41431004724 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431004725 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 41431004726 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 41431004727 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 41431004728 anti sigma factor interaction site; other site 41431004729 regulatory phosphorylation site [posttranslational modification]; other site 41431004730 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 41431004731 Bacterial sugar transferase; Region: Bac_transf; pfam02397 41431004732 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 41431004733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 41431004734 Protein of unknown function (DUF721); Region: DUF721; cl02324 41431004735 flavoprotein, HI0933 family; Region: TIGR00275 41431004736 short chain dehydrogenase; Provisional; Region: PRK06172 41431004737 classical (c) SDRs; Region: SDR_c; cd05233 41431004738 NAD(P) binding site [chemical binding]; other site 41431004739 active site 41431004740 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 41431004741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431004742 motif II; other site 41431004743 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 41431004744 intersubunit interface [polypeptide binding]; other site 41431004745 active site 41431004746 Zn2+ binding site [ion binding]; other site 41431004747 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 41431004748 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 41431004749 TM-ABC transporter signature motif; other site 41431004750 response regulator FixJ; Provisional; Region: fixJ; PRK09390 41431004751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431004752 active site 41431004753 phosphorylation site [posttranslational modification] 41431004754 intermolecular recognition site; other site 41431004755 dimerization interface [polypeptide binding]; other site 41431004756 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431004757 DNA binding residues [nucleotide binding] 41431004758 dimerization interface [polypeptide binding]; other site 41431004759 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 41431004760 dimer interface [polypeptide binding]; other site 41431004761 [2Fe-2S] cluster binding site [ion binding]; other site 41431004762 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 41431004763 putative lipid kinase; Reviewed; Region: PRK13057 41431004764 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 41431004765 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 41431004766 Ligand Binding Site [chemical binding]; other site 41431004767 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431004768 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431004769 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 41431004770 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431004771 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431004772 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431004773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431004774 dimer interface [polypeptide binding]; other site 41431004775 phosphorylation site [posttranslational modification] 41431004776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431004777 ATP binding site [chemical binding]; other site 41431004778 Mg2+ binding site [ion binding]; other site 41431004779 G-X-G motif; other site 41431004780 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 41431004781 ribosomal protein S14; Region: rps14; CHL00074 41431004782 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 41431004783 C-terminal peptidase (prc); Region: prc; TIGR00225 41431004784 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 41431004785 protein binding site [polypeptide binding]; other site 41431004786 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 41431004787 Catalytic dyad [active] 41431004788 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 41431004789 nudix motif; other site 41431004790 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 41431004791 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 41431004792 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 41431004793 homodimer interface [polypeptide binding]; other site 41431004794 NADP binding site [chemical binding]; other site 41431004795 substrate binding site [chemical binding]; other site 41431004796 Protein of unknown function (DUF563); Region: DUF563; pfam04577 41431004797 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 41431004798 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 41431004799 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 41431004800 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 41431004801 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 41431004802 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 41431004803 Hexamer interface [polypeptide binding]; other site 41431004804 Hexagonal pore residue; other site 41431004805 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 41431004806 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 41431004807 Hexamer interface [polypeptide binding]; other site 41431004808 Hexagonal pore residue; other site 41431004809 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 41431004810 Hexamer/Pentamer interface [polypeptide binding]; other site 41431004811 central pore; other site 41431004812 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 41431004813 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 41431004814 trimer interface [polypeptide binding]; other site 41431004815 active site 41431004816 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 41431004817 putative multimerization interface [polypeptide binding]; other site 41431004818 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 41431004819 putative multimerization interface [polypeptide binding]; other site 41431004820 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 41431004821 putative multimerization interface [polypeptide binding]; other site 41431004822 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 41431004823 putative multimerization interface [polypeptide binding]; other site 41431004824 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 41431004825 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004826 putative active site [active] 41431004827 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 41431004828 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 41431004829 homodimer interface [polypeptide binding]; other site 41431004830 active site 41431004831 heterodimer interface [polypeptide binding]; other site 41431004832 catalytic residue [active] 41431004833 metal binding site [ion binding]; metal-binding site 41431004834 RbcX protein; Region: RcbX; pfam02341 41431004835 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 41431004836 multimerization interface [polypeptide binding]; other site 41431004837 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 41431004838 oligomeric interface; other site 41431004839 putative active site [active] 41431004840 homodimer interface [polypeptide binding]; other site 41431004841 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 41431004842 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 41431004843 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 41431004844 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 41431004845 hexamer interface [polypeptide binding]; other site 41431004846 ligand binding site [chemical binding]; other site 41431004847 putative active site [active] 41431004848 NAD(P) binding site [chemical binding]; other site 41431004849 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 41431004850 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 41431004851 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 41431004852 Walker A motif; other site 41431004853 ATP binding site [chemical binding]; other site 41431004854 Walker B motif; other site 41431004855 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 41431004856 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 41431004857 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 41431004858 Walker A motif; other site 41431004859 ATP binding site [chemical binding]; other site 41431004860 Walker B motif; other site 41431004861 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 41431004862 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 41431004863 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 41431004864 Uncharacterized conserved protein [Function unknown]; Region: COG2006 41431004865 Domain of unknown function (DUF362); Region: DUF362; pfam04015 41431004866 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 41431004867 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 41431004868 classical (c) SDRs; Region: SDR_c; cd05233 41431004869 NAD(P) binding site [chemical binding]; other site 41431004870 active site 41431004871 muropeptide transporter; Reviewed; Region: ampG; PRK11902 41431004872 muropeptide transporter; Validated; Region: ampG; cl17669 41431004873 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 41431004874 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 41431004875 substrate binding site [chemical binding]; other site 41431004876 hexamer interface [polypeptide binding]; other site 41431004877 metal binding site [ion binding]; metal-binding site 41431004878 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004879 putative active site [active] 41431004880 Predicted membrane protein [Function unknown]; Region: COG4803 41431004881 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 41431004882 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 41431004883 putative di-iron ligands [ion binding]; other site 41431004884 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 41431004885 polyphosphate kinase; Provisional; Region: PRK05443 41431004886 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 41431004887 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 41431004888 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 41431004889 putative domain interface [polypeptide binding]; other site 41431004890 putative active site [active] 41431004891 catalytic site [active] 41431004892 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 41431004893 putative domain interface [polypeptide binding]; other site 41431004894 putative active site [active] 41431004895 catalytic site [active] 41431004896 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431004897 catalytic loop [active] 41431004898 iron binding site [ion binding]; other site 41431004899 cobyric acid synthase; Provisional; Region: PRK00784 41431004900 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 41431004901 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 41431004902 catalytic triad [active] 41431004903 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 41431004904 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 41431004905 catalytic triad [active] 41431004906 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 41431004907 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431004908 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 41431004909 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 41431004910 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 41431004911 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 41431004912 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 41431004913 Substrate binding site; other site 41431004914 Mg++ binding site; other site 41431004915 metal-binding site 41431004916 Mg++ binding site; other site 41431004917 metal-binding site 41431004918 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 41431004919 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 41431004920 Tetramer interface [polypeptide binding]; other site 41431004921 active site 41431004922 FMN-binding site [chemical binding]; other site 41431004923 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431004924 phosphopeptide binding site; other site 41431004925 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 41431004926 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431004927 phosphopeptide binding site; other site 41431004928 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 41431004929 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 41431004930 Walker A/P-loop; other site 41431004931 ATP binding site [chemical binding]; other site 41431004932 Q-loop/lid; other site 41431004933 ABC transporter signature motif; other site 41431004934 Walker B; other site 41431004935 D-loop; other site 41431004936 H-loop/switch region; other site 41431004937 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 41431004938 ferredoxin-sulfite reductase; Region: sir; TIGR02042 41431004939 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 41431004940 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 41431004941 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 41431004942 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 41431004943 MgtE intracellular N domain; Region: MgtE_N; smart00924 41431004944 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 41431004945 Divalent cation transporter; Region: MgtE; pfam01769 41431004946 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431004947 structural tetrad; other site 41431004948 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431004949 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 41431004950 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 41431004951 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 41431004952 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 41431004953 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 41431004954 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 41431004955 protein-splicing catalytic site; other site 41431004956 thioester formation/cholesterol transfer; other site 41431004957 HNH endonuclease; Region: HNH_3; pfam13392 41431004958 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 41431004959 protein-splicing catalytic site; other site 41431004960 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 41431004961 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 41431004962 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 41431004963 [2Fe-2S] cluster binding site [ion binding]; other site 41431004964 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 41431004965 hydrophobic ligand binding site; other site 41431004966 arginine decarboxylase; Provisional; Region: PRK05354 41431004967 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 41431004968 dimer interface [polypeptide binding]; other site 41431004969 active site 41431004970 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 41431004971 catalytic residues [active] 41431004972 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 41431004973 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 41431004974 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl11892 41431004975 CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cl11893 41431004976 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 41431004977 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 41431004978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431004979 NACHT domain; Region: NACHT; pfam05729 41431004980 Walker A motif; other site 41431004981 ATP binding site [chemical binding]; other site 41431004982 Walker B motif; other site 41431004983 arginine finger; other site 41431004984 TniQ; Region: TniQ; pfam06527 41431004985 AAA domain; Region: AAA_22; pfam13401 41431004986 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 41431004987 Helix-turn-helix domain; Region: HTH_28; pfam13518 41431004988 Integrase core domain; Region: rve; pfam00665 41431004989 YcfA-like protein; Region: YcfA; cl00752 41431004990 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431004991 Predicted helicase [General function prediction only]; Region: COG4889 41431004992 Methyltransferase domain; Region: Methyltransf_26; pfam13659 41431004993 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431004994 putative active site [active] 41431004995 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 41431004996 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 41431004997 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 41431004998 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 41431004999 active site 41431005000 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 41431005001 Exoribonuclease R [Transcription]; Region: VacB; COG0557 41431005002 RNB domain; Region: RNB; pfam00773 41431005003 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 41431005004 ribosomal protein L33; Region: rpl33; CHL00104 41431005005 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 41431005006 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 41431005007 FMN binding site [chemical binding]; other site 41431005008 active site 41431005009 substrate binding site [chemical binding]; other site 41431005010 catalytic residue [active] 41431005011 MarR family; Region: MarR_2; cl17246 41431005012 putative phosphoketolase; Provisional; Region: PRK05261 41431005013 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 41431005014 TPP-binding site; other site 41431005015 XFP C-terminal domain; Region: XFP_C; pfam09363 41431005016 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 41431005017 catalytic triad [active] 41431005018 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 41431005019 active site 41431005020 oxyanion hole [active] 41431005021 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 41431005022 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 41431005023 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 41431005024 dihydrodipicolinate reductase; Provisional; Region: PRK00048 41431005025 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 41431005026 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 41431005027 Protein of unknown function (DUF938); Region: DUF938; pfam06080 41431005028 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 41431005029 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 41431005030 generic binding surface II; other site 41431005031 generic binding surface I; other site 41431005032 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 41431005033 putative active site [active] 41431005034 putative catalytic site [active] 41431005035 putative Mg binding site IVb [ion binding]; other site 41431005036 putative phosphate binding site [ion binding]; other site 41431005037 putative DNA binding site [nucleotide binding]; other site 41431005038 putative Mg binding site IVa [ion binding]; other site 41431005039 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 41431005040 Predicted transcriptional regulators [Transcription]; Region: COG1733 41431005041 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 41431005042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 41431005043 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 41431005044 enolase; Provisional; Region: eno; PRK00077 41431005045 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 41431005046 dimer interface [polypeptide binding]; other site 41431005047 metal binding site [ion binding]; metal-binding site 41431005048 substrate binding pocket [chemical binding]; other site 41431005049 PUCC protein; Region: PUCC; pfam03209 41431005050 4-alpha-glucanotransferase; Provisional; Region: PRK14508 41431005051 phosphodiesterase; Provisional; Region: PRK12704 41431005052 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 41431005053 dimerization interface [polypeptide binding]; other site 41431005054 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 41431005055 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 41431005056 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 41431005057 catalytic residue [active] 41431005058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 41431005059 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 41431005060 pyrroline-5-carboxylate reductase; Region: PLN02688 41431005061 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 41431005062 Cytochrome P450; Region: p450; pfam00067 41431005063 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 41431005064 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431005065 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 41431005066 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 41431005067 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 41431005068 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 41431005069 FMN binding site [chemical binding]; other site 41431005070 active site 41431005071 catalytic residues [active] 41431005072 substrate binding site [chemical binding]; other site 41431005073 hydrolase, alpha/beta fold family protein; Region: PLN02824 41431005074 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 41431005075 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 41431005076 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 41431005077 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 41431005078 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 41431005079 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 41431005080 Ligand Binding Site [chemical binding]; other site 41431005081 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431005082 Ligand Binding Site [chemical binding]; other site 41431005083 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 41431005084 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 41431005085 GAF domain; Region: GAF; pfam01590 41431005086 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431005087 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431005088 metal binding site [ion binding]; metal-binding site 41431005089 active site 41431005090 I-site; other site 41431005091 Response regulator receiver domain; Region: Response_reg; pfam00072 41431005092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005093 active site 41431005094 phosphorylation site [posttranslational modification] 41431005095 intermolecular recognition site; other site 41431005096 dimerization interface [polypeptide binding]; other site 41431005097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431005098 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 41431005099 dimer interface [polypeptide binding]; other site 41431005100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431005101 ATP binding site [chemical binding]; other site 41431005102 Mg2+ binding site [ion binding]; other site 41431005103 G-X-G motif; other site 41431005104 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431005105 GAF domain; Region: GAF; cl17456 41431005106 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431005107 GAF domain; Region: GAF; pfam01590 41431005108 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431005109 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431005110 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431005111 GAF domain; Region: GAF; pfam01590 41431005112 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431005113 GAF domain; Region: GAF; pfam01590 41431005114 PAS domain; Region: PAS; smart00091 41431005115 PAS fold; Region: PAS_4; pfam08448 41431005116 putative active site [active] 41431005117 heme pocket [chemical binding]; other site 41431005118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431005119 phosphorylation site [posttranslational modification] 41431005120 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 41431005121 Ycf46; Provisional; Region: ycf46; CHL00195 41431005122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431005123 Walker A motif; other site 41431005124 ATP binding site [chemical binding]; other site 41431005125 Walker B motif; other site 41431005126 arginine finger; other site 41431005127 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 41431005128 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 41431005129 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 41431005130 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 41431005131 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 41431005132 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005133 putative active site [active] 41431005134 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 41431005135 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 41431005136 Haemolytic domain; Region: Haemolytic; pfam01809 41431005137 hypothetical protein; Provisional; Region: PRK02237 41431005138 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 41431005139 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 41431005140 C-terminal domain interface [polypeptide binding]; other site 41431005141 active site 41431005142 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 41431005143 active site 41431005144 N-terminal domain interface [polypeptide binding]; other site 41431005145 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 41431005146 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 41431005147 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 41431005148 putative metal binding site; other site 41431005149 TPR repeat; Region: TPR_11; pfam13414 41431005150 Tetratricopeptide repeat; Region: TPR_1; pfam00515 41431005151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005152 binding surface 41431005153 TPR repeat; Region: TPR_11; pfam13414 41431005154 TPR motif; other site 41431005155 Tetratricopeptide repeat; Region: TPR_16; pfam13432 41431005156 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 41431005157 peripheral dimer interface [polypeptide binding]; other site 41431005158 core dimer interface [polypeptide binding]; other site 41431005159 L10 interface [polypeptide binding]; other site 41431005160 L11 interface [polypeptide binding]; other site 41431005161 putative EF-Tu interaction site [polypeptide binding]; other site 41431005162 putative EF-G interaction site [polypeptide binding]; other site 41431005163 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 41431005164 23S rRNA interface [nucleotide binding]; other site 41431005165 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 41431005166 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 41431005167 mRNA/rRNA interface [nucleotide binding]; other site 41431005168 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 41431005169 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 41431005170 23S rRNA interface [nucleotide binding]; other site 41431005171 L7/L12 interface [polypeptide binding]; other site 41431005172 putative thiostrepton binding site; other site 41431005173 L25 interface [polypeptide binding]; other site 41431005174 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 41431005175 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 41431005176 putative homodimer interface [polypeptide binding]; other site 41431005177 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 41431005178 heterodimer interface [polypeptide binding]; other site 41431005179 homodimer interface [polypeptide binding]; other site 41431005180 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 41431005181 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 41431005182 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431005183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005184 binding surface 41431005185 TPR motif; other site 41431005186 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431005187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431005188 Tetratricopeptide repeat; Region: TPR_10; pfam13374 41431005189 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431005190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005191 binding surface 41431005192 TPR motif; other site 41431005193 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431005194 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431005195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005196 binding surface 41431005197 TPR motif; other site 41431005198 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431005199 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 41431005200 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 41431005201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431005202 catalytic residue [active] 41431005203 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 41431005204 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 41431005205 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 41431005206 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 41431005207 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 41431005208 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 41431005209 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 41431005210 DNA binding site [nucleotide binding] 41431005211 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 41431005212 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 41431005213 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 41431005214 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 41431005215 RPB1 interaction site [polypeptide binding]; other site 41431005216 RPB10 interaction site [polypeptide binding]; other site 41431005217 RPB11 interaction site [polypeptide binding]; other site 41431005218 RPB3 interaction site [polypeptide binding]; other site 41431005219 RPB12 interaction site [polypeptide binding]; other site 41431005220 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 41431005221 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 41431005222 active site 41431005223 ribosomal protein S20; Region: rps20; CHL00102 41431005224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 41431005225 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 41431005226 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 41431005227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431005228 Walker A/P-loop; other site 41431005229 ATP binding site [chemical binding]; other site 41431005230 Q-loop/lid; other site 41431005231 ABC transporter signature motif; other site 41431005232 Walker B; other site 41431005233 D-loop; other site 41431005234 H-loop/switch region; other site 41431005235 TOBE domain; Region: TOBE_2; pfam08402 41431005236 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 41431005237 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 41431005238 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 41431005239 Walker A/P-loop; other site 41431005240 ATP binding site [chemical binding]; other site 41431005241 Q-loop/lid; other site 41431005242 ABC transporter signature motif; other site 41431005243 Walker B; other site 41431005244 D-loop; other site 41431005245 H-loop/switch region; other site 41431005246 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 41431005247 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 41431005248 Walker A/P-loop; other site 41431005249 ATP binding site [chemical binding]; other site 41431005250 Q-loop/lid; other site 41431005251 ABC transporter signature motif; other site 41431005252 Walker B; other site 41431005253 D-loop; other site 41431005254 H-loop/switch region; other site 41431005255 Cobalt transport protein; Region: CbiQ; cl00463 41431005256 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005257 putative active site [active] 41431005258 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 41431005259 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 41431005260 putative catalytic cysteine [active] 41431005261 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 41431005262 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 41431005263 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 41431005264 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 41431005265 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 41431005266 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 41431005267 active site 41431005268 substrate binding site [chemical binding]; other site 41431005269 metal binding site [ion binding]; metal-binding site 41431005270 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 41431005271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431005272 FeS/SAM binding site; other site 41431005273 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 41431005274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431005275 Walker A/P-loop; other site 41431005276 ATP binding site [chemical binding]; other site 41431005277 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 41431005278 PIN domain; Region: PIN_3; cl17397 41431005279 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 41431005280 ArsC family; Region: ArsC; pfam03960 41431005281 putative catalytic residues [active] 41431005282 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 41431005283 dimer interface [polypeptide binding]; other site 41431005284 [2Fe-2S] cluster binding site [ion binding]; other site 41431005285 NifT/FixU protein; Region: NifT; pfam06988 41431005286 NifZ domain; Region: NifZ; pfam04319 41431005287 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 41431005288 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 41431005289 active site 41431005290 catalytic residues [active] 41431005291 metal binding site [ion binding]; metal-binding site 41431005292 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 41431005293 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 41431005294 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 41431005295 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 41431005296 trimer interface [polypeptide binding]; other site 41431005297 active site 41431005298 substrate binding site [chemical binding]; other site 41431005299 CoA binding site [chemical binding]; other site 41431005300 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 41431005301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431005302 FeS/SAM binding site; other site 41431005303 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 41431005304 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 41431005305 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 41431005306 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 41431005307 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 41431005308 catalytic residue [active] 41431005309 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 41431005310 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 41431005311 trimerization site [polypeptide binding]; other site 41431005312 active site 41431005313 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 41431005314 NifU-like domain; Region: NifU; pfam01106 41431005315 nitrogenase reductase; Reviewed; Region: PRK13236 41431005316 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 41431005317 Nucleotide-binding sites [chemical binding]; other site 41431005318 Walker A motif; other site 41431005319 Switch I region of nucleotide binding site; other site 41431005320 Fe4S4 binding sites [ion binding]; other site 41431005321 Switch II region of nucleotide binding site; other site 41431005322 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 41431005323 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 41431005324 MoFe protein alpha/beta subunit interactions; other site 41431005325 Alpha subunit P cluster binding residues; other site 41431005326 FeMoco binding residues [chemical binding]; other site 41431005327 MoFe protein alpha subunit/Fe protein contacts; other site 41431005328 MoFe protein dimer/ dimer interactions; other site 41431005329 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 41431005330 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 41431005331 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 41431005332 MoFe protein beta/alpha subunit interactions; other site 41431005333 Beta subunit P cluster binding residues; other site 41431005334 MoFe protein beta subunit/Fe protein contacts; other site 41431005335 MoFe protein dimer/ dimer interactions; other site 41431005336 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 41431005337 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 41431005338 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 41431005339 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 41431005340 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 41431005341 Protein of unknown function, DUF269; Region: DUF269; pfam03270 41431005342 Rop-like; Region: Rop-like; pfam05082 41431005343 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102 41431005344 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 41431005345 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 41431005346 ATP binding site [chemical binding]; other site 41431005347 substrate interface [chemical binding]; other site 41431005348 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 41431005349 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 41431005350 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431005351 catalytic loop [active] 41431005352 iron binding site [ion binding]; other site 41431005353 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 41431005354 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 41431005355 G1 box; other site 41431005356 GTP/Mg2+ binding site [chemical binding]; other site 41431005357 Switch I region; other site 41431005358 G2 box; other site 41431005359 G3 box; other site 41431005360 Switch II region; other site 41431005361 G4 box; other site 41431005362 G5 box; other site 41431005363 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 41431005364 Nucleoside recognition; Region: Gate; pfam07670 41431005365 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 41431005366 Nucleoside recognition; Region: Gate; pfam07670 41431005367 FeoA domain; Region: FeoA; pfam04023 41431005368 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 41431005369 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 41431005370 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 41431005371 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 41431005372 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 41431005373 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 41431005374 dimer interface [polypeptide binding]; other site 41431005375 active site 41431005376 CoA binding pocket [chemical binding]; other site 41431005377 putative phosphate acyltransferase; Provisional; Region: PRK05331 41431005378 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 41431005379 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 41431005380 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 41431005381 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431005382 active site 41431005383 ATP binding site [chemical binding]; other site 41431005384 substrate binding site [chemical binding]; other site 41431005385 activation loop (A-loop); other site 41431005386 Uncharacterized conserved protein [Function unknown]; Region: COG1262 41431005387 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 41431005388 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431005389 Protein required for attachment to host cells; Region: Host_attach; pfam10116 41431005390 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 41431005391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005392 active site 41431005393 phosphorylation site [posttranslational modification] 41431005394 intermolecular recognition site; other site 41431005395 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 41431005396 dimerization interface [polypeptide binding]; other site 41431005397 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431005398 DNA binding residues [nucleotide binding] 41431005399 dimerization interface [polypeptide binding]; other site 41431005400 Uncharacterized conserved protein [Function unknown]; Region: COG3339 41431005401 Protein of unknown function, DUF393; Region: DUF393; pfam04134 41431005402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 41431005403 Transposase; Region: HTH_Tnp_1; cl17663 41431005404 Transposase; Region: DDE_Tnp_ISL3; pfam01610 41431005405 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431005406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005407 binding surface 41431005408 TPR motif; other site 41431005409 PemK-like protein; Region: PemK; pfam02452 41431005410 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 41431005411 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 41431005412 dimer interface [polypeptide binding]; other site 41431005413 anticodon binding site; other site 41431005414 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 41431005415 homodimer interface [polypeptide binding]; other site 41431005416 motif 1; other site 41431005417 active site 41431005418 motif 2; other site 41431005419 GAD domain; Region: GAD; pfam02938 41431005420 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 41431005421 active site 41431005422 motif 3; other site 41431005423 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 41431005424 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 41431005425 active site 41431005426 catalytic triad [active] 41431005427 oxyanion hole [active] 41431005428 MAPEG family; Region: MAPEG; cl09190 41431005429 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 41431005430 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 41431005431 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 41431005432 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 41431005433 CHASE2 domain; Region: CHASE2; pfam05226 41431005434 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 41431005435 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431005436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431005437 metal binding site [ion binding]; metal-binding site 41431005438 active site 41431005439 I-site; other site 41431005440 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431005441 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 41431005442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431005443 motif II; other site 41431005444 S-adenosylmethionine synthetase; Validated; Region: PRK05250 41431005445 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 41431005446 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 41431005447 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 41431005448 MbtH-like protein; Region: MbtH; cl01279 41431005449 Condensation domain; Region: Condensation; pfam00668 41431005450 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431005451 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 41431005452 acyl-activating enzyme (AAE) consensus motif; other site 41431005453 AMP binding site [chemical binding]; other site 41431005454 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431005455 Condensation domain; Region: Condensation; pfam00668 41431005456 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431005457 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 41431005458 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 41431005459 acyl-activating enzyme (AAE) consensus motif; other site 41431005460 AMP binding site [chemical binding]; other site 41431005461 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431005462 Condensation domain; Region: Condensation; pfam00668 41431005463 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431005464 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 41431005465 HlyD family secretion protein; Region: HlyD_3; pfam13437 41431005466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005467 TPR repeat; Region: TPR_11; pfam13414 41431005468 binding surface 41431005469 TPR motif; other site 41431005470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005471 binding surface 41431005472 TPR motif; other site 41431005473 TPR repeat; Region: TPR_11; pfam13414 41431005474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005475 binding surface 41431005476 TPR motif; other site 41431005477 TPR repeat; Region: TPR_11; pfam13414 41431005478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005479 binding surface 41431005480 TPR motif; other site 41431005481 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 41431005482 tetramerization interface [polypeptide binding]; other site 41431005483 active site 41431005484 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 41431005485 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 41431005486 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 41431005487 acyl-activating enzyme (AAE) consensus motif; other site 41431005488 AMP binding site [chemical binding]; other site 41431005489 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431005490 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 41431005491 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 41431005492 metal binding site 2 [ion binding]; metal-binding site 41431005493 putative DNA binding helix; other site 41431005494 metal binding site 1 [ion binding]; metal-binding site 41431005495 dimer interface [polypeptide binding]; other site 41431005496 structural Zn2+ binding site [ion binding]; other site 41431005497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 41431005498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005499 active site 41431005500 dimerization interface [polypeptide binding]; other site 41431005501 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 41431005502 cell division protein; Validated; Region: ftsH; CHL00176 41431005503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431005504 Walker A motif; other site 41431005505 ATP binding site [chemical binding]; other site 41431005506 Walker B motif; other site 41431005507 arginine finger; other site 41431005508 Peptidase family M41; Region: Peptidase_M41; pfam01434 41431005509 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 41431005510 anti sigma factor interaction site; other site 41431005511 regulatory phosphorylation site [posttranslational modification]; other site 41431005512 Response regulator receiver domain; Region: Response_reg; pfam00072 41431005513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005514 active site 41431005515 phosphorylation site [posttranslational modification] 41431005516 intermolecular recognition site; other site 41431005517 dimerization interface [polypeptide binding]; other site 41431005518 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 41431005519 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 41431005520 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 41431005521 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 41431005522 ATP binding site [chemical binding]; other site 41431005523 Mg2+ binding site [ion binding]; other site 41431005524 G-X-G motif; other site 41431005525 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 41431005526 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 41431005527 active site residue [active] 41431005528 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 41431005529 active site residue [active] 41431005530 Uncharacterized conserved protein [Function unknown]; Region: COG1432 41431005531 LabA_like proteins; Region: LabA; cd10911 41431005532 putative metal binding site [ion binding]; other site 41431005533 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 41431005534 Nitrogen regulatory protein P-II; Region: P-II; smart00938 41431005535 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 41431005536 active site 41431005537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005538 TPR motif; other site 41431005539 TPR repeat; Region: TPR_11; pfam13414 41431005540 binding surface 41431005541 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431005542 active site 41431005543 NTP binding site [chemical binding]; other site 41431005544 metal binding triad [ion binding]; metal-binding site 41431005545 antibiotic binding site [chemical binding]; other site 41431005546 Uncharacterized conserved protein [Function unknown]; Region: COG2361 41431005547 Tetratricopeptide repeat; Region: TPR_16; pfam13432 41431005548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431005549 TPR motif; other site 41431005550 Erythromycin esterase; Region: Erythro_esteras; cl17110 41431005551 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431005552 active site 41431005553 NTP binding site [chemical binding]; other site 41431005554 metal binding triad [ion binding]; metal-binding site 41431005555 antibiotic binding site [chemical binding]; other site 41431005556 Uncharacterized conserved protein [Function unknown]; Region: COG2361 41431005557 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005558 putative active site [active] 41431005559 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 41431005560 L-aspartate oxidase; Provisional; Region: PRK06175 41431005561 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 41431005562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431005563 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431005564 Probable transposase; Region: OrfB_IS605; pfam01385 41431005565 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431005566 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005567 putative active site [active] 41431005568 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 41431005569 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 41431005570 Hexamer interface [polypeptide binding]; other site 41431005571 Hexagonal pore residue; other site 41431005572 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 41431005573 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 41431005574 Hexamer interface [polypeptide binding]; other site 41431005575 Hexagonal pore residue; other site 41431005576 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431005577 extended (e) SDRs; Region: SDR_e; cd08946 41431005578 NAD(P) binding site [chemical binding]; other site 41431005579 active site 41431005580 substrate binding site [chemical binding]; other site 41431005581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431005582 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 41431005583 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 41431005584 Walker A/P-loop; other site 41431005585 ATP binding site [chemical binding]; other site 41431005586 Q-loop/lid; other site 41431005587 ABC transporter signature motif; other site 41431005588 Walker B; other site 41431005589 D-loop; other site 41431005590 H-loop/switch region; other site 41431005591 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 41431005592 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 41431005593 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 41431005594 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 41431005595 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 41431005596 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 41431005597 UbiA prenyltransferase family; Region: UbiA; pfam01040 41431005598 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005599 putative active site [active] 41431005600 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 41431005601 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 41431005602 quinone interaction residues [chemical binding]; other site 41431005603 active site 41431005604 catalytic residues [active] 41431005605 FMN binding site [chemical binding]; other site 41431005606 substrate binding site [chemical binding]; other site 41431005607 homoserine kinase; Provisional; Region: PRK01212 41431005608 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 41431005609 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 41431005610 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 41431005611 putative active site [active] 41431005612 PemK-like protein; Region: PemK; pfam02452 41431005613 Domain of unknown function (DUF3825); Region: DUF3825; pfam12873 41431005614 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 41431005615 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 41431005616 substrate binding site [chemical binding]; other site 41431005617 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 41431005618 substrate binding site [chemical binding]; other site 41431005619 ligand binding site [chemical binding]; other site 41431005620 XisI protein; Region: XisI; pfam08869 41431005621 Uncharacterized conserved protein [Function unknown]; Region: COG2442 41431005622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 41431005623 XisI protein; Region: XisI; pfam08869 41431005624 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 41431005625 Predicted permeases [General function prediction only]; Region: COG0679 41431005626 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005627 putative active site [active] 41431005628 Cytochrome P450; Region: p450; pfam00067 41431005629 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 41431005630 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 41431005631 Ycf35; Provisional; Region: ycf35; CHL00193 41431005632 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 41431005633 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431005634 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 41431005635 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 41431005636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431005637 dimer interface [polypeptide binding]; other site 41431005638 conserved gate region; other site 41431005639 putative PBP binding loops; other site 41431005640 ABC-ATPase subunit interface; other site 41431005641 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 41431005642 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 41431005643 dimerization interface [polypeptide binding]; other site 41431005644 putative active cleft [active] 41431005645 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 41431005646 conserved cys residue [active] 41431005647 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 41431005648 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 41431005649 potential catalytic triad [active] 41431005650 conserved cys residue [active] 41431005651 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 41431005652 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 41431005653 PYR/PP interface [polypeptide binding]; other site 41431005654 dimer interface [polypeptide binding]; other site 41431005655 TPP binding site [chemical binding]; other site 41431005656 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 41431005657 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 41431005658 TPP-binding site [chemical binding]; other site 41431005659 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 41431005660 amphipathic channel; other site 41431005661 Asn-Pro-Ala signature motifs; other site 41431005662 Protein of unknown function (DUF751); Region: DUF751; pfam05421 41431005663 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 41431005664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 41431005665 Uncharacterized conserved protein [Function unknown]; Region: COG2308 41431005666 Predicted dehydrogenase [General function prediction only]; Region: COG0579 41431005667 hydroxyglutarate oxidase; Provisional; Region: PRK11728 41431005668 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005669 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431005670 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005671 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005672 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 41431005673 NADH(P)-binding; Region: NAD_binding_10; pfam13460 41431005674 NAD(P) binding site [chemical binding]; other site 41431005675 putative active site [active] 41431005676 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 41431005677 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431005678 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 41431005679 phosphopeptide binding site; other site 41431005680 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 41431005681 Transglycosylase; Region: Transgly; pfam00912 41431005682 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 41431005683 FtsH Extracellular; Region: FtsH_ext; pfam06480 41431005684 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 41431005685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431005686 Walker A motif; other site 41431005687 ATP binding site [chemical binding]; other site 41431005688 Walker B motif; other site 41431005689 arginine finger; other site 41431005690 Peptidase family M41; Region: Peptidase_M41; pfam01434 41431005691 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 41431005692 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 41431005693 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 41431005694 active site 41431005695 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 41431005696 homotrimer interaction site [polypeptide binding]; other site 41431005697 putative active site [active] 41431005698 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 41431005699 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 41431005700 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 41431005701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005702 active site 41431005703 phosphorylation site [posttranslational modification] 41431005704 intermolecular recognition site; other site 41431005705 dimerization interface [polypeptide binding]; other site 41431005706 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431005707 DNA binding residues [nucleotide binding] 41431005708 dimerization interface [polypeptide binding]; other site 41431005709 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431005710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431005711 dimer interface [polypeptide binding]; other site 41431005712 phosphorylation site [posttranslational modification] 41431005713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431005714 ATP binding site [chemical binding]; other site 41431005715 Mg2+ binding site [ion binding]; other site 41431005716 G-X-G motif; other site 41431005717 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 41431005718 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 41431005719 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 41431005720 Soluble P-type ATPase [General function prediction only]; Region: COG4087 41431005721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431005722 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431005723 Probable transposase; Region: OrfB_IS605; pfam01385 41431005724 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 41431005725 potassium-transporting ATPase subunit C; Provisional; Region: PRK14003 41431005726 Electron transfer DM13; Region: DM13; pfam10517 41431005727 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 41431005728 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431005729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005730 active site 41431005731 phosphorylation site [posttranslational modification] 41431005732 intermolecular recognition site; other site 41431005733 dimerization interface [polypeptide binding]; other site 41431005734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431005735 DNA binding site [nucleotide binding] 41431005736 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 41431005737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431005738 ATP binding site [chemical binding]; other site 41431005739 Mg2+ binding site [ion binding]; other site 41431005740 G-X-G motif; other site 41431005741 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 41431005742 ATP binding site [chemical binding]; other site 41431005743 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 41431005744 Protein of unknown function (DUF565); Region: DUF565; pfam04483 41431005745 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 41431005746 active site 41431005747 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 41431005748 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 41431005749 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 41431005750 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 41431005751 active site 41431005752 homodimer interface [polypeptide binding]; other site 41431005753 catalytic site [active] 41431005754 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005755 putative active site [active] 41431005756 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 41431005757 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 41431005758 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 41431005759 Sporulation related domain; Region: SPOR; pfam05036 41431005760 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 41431005761 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431005762 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005763 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005764 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431005765 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005766 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431005767 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431005768 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 41431005769 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 41431005770 HD domain; Region: HD_5; pfam13487 41431005771 cytosine deaminase-like protein; Validated; Region: PRK07583 41431005772 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 41431005773 active site 41431005774 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 41431005775 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 41431005776 Cysteine-rich domain; Region: CCG; pfam02754 41431005777 Cysteine-rich domain; Region: CCG; pfam02754 41431005778 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 41431005779 FAD binding domain; Region: FAD_binding_4; pfam01565 41431005780 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 41431005781 KH domain; Region: KH_4; pfam13083 41431005782 G-X-X-G motif; other site 41431005783 ribosomal protein S16; Region: rps16; CHL00005 41431005784 Uncharacterized conserved protein [Function unknown]; Region: COG1434 41431005785 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 41431005786 putative active site [active] 41431005787 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 41431005788 hypothetical protein; Provisional; Region: PRK13683 41431005789 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 41431005790 D1 interface; other site 41431005791 chlorophyll binding site; other site 41431005792 pheophytin binding site; other site 41431005793 beta carotene binding site; other site 41431005794 cytochrome b559 beta interface; other site 41431005795 quinone binding site; other site 41431005796 cytochrome b559 alpha interface; other site 41431005797 protein J interface; other site 41431005798 protein H interface; other site 41431005799 protein X interface; other site 41431005800 core light harvesting protein interface; other site 41431005801 protein L interface; other site 41431005802 CP43 interface; other site 41431005803 protein T interface; other site 41431005804 Fe binding site [ion binding]; other site 41431005805 protein M interface; other site 41431005806 Mn-stabilizing polypeptide interface; other site 41431005807 bromide binding site; other site 41431005808 cytochrome c-550 interface; other site 41431005809 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 41431005810 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 41431005811 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 41431005812 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 41431005813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 41431005814 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 41431005815 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 41431005816 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 41431005817 HlyD family secretion protein; Region: HlyD_3; pfam13437 41431005818 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 41431005819 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 41431005820 FtsX-like permease family; Region: FtsX; pfam02687 41431005821 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 41431005822 Protein of unknown function (DUF497); Region: DUF497; pfam04365 41431005823 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 41431005824 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 41431005825 active site 41431005826 NTP binding site [chemical binding]; other site 41431005827 metal binding triad [ion binding]; metal-binding site 41431005828 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 41431005829 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 41431005830 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 41431005831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431005832 Walker A motif; other site 41431005833 ATP binding site [chemical binding]; other site 41431005834 Walker B motif; other site 41431005835 arginine finger; other site 41431005836 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 41431005837 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 41431005838 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 41431005839 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 41431005840 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 41431005841 active site 41431005842 zinc binding site [ion binding]; other site 41431005843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431005844 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 41431005845 Coenzyme A binding pocket [chemical binding]; other site 41431005846 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 41431005847 Phage Tail Collar Domain; Region: Collar; pfam07484 41431005848 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 41431005849 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 41431005850 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 41431005851 active site 41431005852 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 41431005853 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 41431005854 acetylornithine aminotransferase; Provisional; Region: PRK02627 41431005855 inhibitor-cofactor binding pocket; inhibition site 41431005856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431005857 catalytic residue [active] 41431005858 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 41431005859 Glycoprotease family; Region: Peptidase_M22; pfam00814 41431005860 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431005861 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 41431005862 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 41431005863 EamA-like transporter family; Region: EamA; pfam00892 41431005864 Uncharacterized conserved protein [Function unknown]; Region: COG1262 41431005865 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 41431005866 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 41431005867 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 41431005868 Walker A/P-loop; other site 41431005869 ATP binding site [chemical binding]; other site 41431005870 Q-loop/lid; other site 41431005871 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 41431005872 ABC transporter signature motif; other site 41431005873 Walker B; other site 41431005874 D-loop; other site 41431005875 H-loop/switch region; other site 41431005876 Homeodomain-like domain; Region: HTH_23; pfam13384 41431005877 Winged helix-turn helix; Region: HTH_29; pfam13551 41431005878 Homeodomain-like domain; Region: HTH_32; pfam13565 41431005879 DDE superfamily endonuclease; Region: DDE_3; pfam13358 41431005880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 41431005881 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 41431005882 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 41431005883 G1 box; other site 41431005884 putative GEF interaction site [polypeptide binding]; other site 41431005885 GTP/Mg2+ binding site [chemical binding]; other site 41431005886 Switch I region; other site 41431005887 G2 box; other site 41431005888 G3 box; other site 41431005889 Switch II region; other site 41431005890 G4 box; other site 41431005891 G5 box; other site 41431005892 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 41431005893 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 41431005894 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431005895 motif II; other site 41431005896 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431005897 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 41431005898 putative NAD(P) binding site [chemical binding]; other site 41431005899 active site 41431005900 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 41431005901 Ligand Binding Site [chemical binding]; other site 41431005902 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 41431005903 PLU-1-like protein; Region: PLU-1; pfam08429 41431005904 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 41431005905 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 41431005906 nudix motif; other site 41431005907 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 41431005908 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 41431005909 domain interfaces; other site 41431005910 active site 41431005911 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 41431005912 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 41431005913 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 41431005914 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431005915 MarC family integral membrane protein; Region: MarC; cl00919 41431005916 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 41431005917 Cytochrome c; Region: Cytochrom_C; cl11414 41431005918 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 41431005919 Stage II sporulation protein; Region: SpoIID; pfam08486 41431005920 SnoaL-like domain; Region: SnoaL_2; pfam12680 41431005921 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 41431005922 protein I interface; other site 41431005923 D2 interface; other site 41431005924 protein T interface; other site 41431005925 chlorophyll binding site; other site 41431005926 beta carotene binding site; other site 41431005927 pheophytin binding site; other site 41431005928 manganese-stabilizing polypeptide interface; other site 41431005929 CP43 interface; other site 41431005930 protein L interface; other site 41431005931 oxygen evolving complex binding site; other site 41431005932 bromide binding site; other site 41431005933 quinone binding site; other site 41431005934 Fe binding site [ion binding]; other site 41431005935 core light harvesting interface; other site 41431005936 cytochrome b559 alpha subunit interface; other site 41431005937 cytochrome c-550 interface; other site 41431005938 protein J interface; other site 41431005939 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005940 putative active site [active] 41431005941 spermidine synthase; Provisional; Region: PRK00811 41431005942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431005943 S-adenosylmethionine binding site [chemical binding]; other site 41431005944 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 41431005945 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 41431005946 putative catalytic cysteine [active] 41431005947 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005948 putative active site [active] 41431005949 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 41431005950 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 41431005951 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 41431005952 Predicted membrane protein [Function unknown]; Region: COG1950 41431005953 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 41431005954 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431005955 ATP binding site [chemical binding]; other site 41431005956 putative Mg++ binding site [ion binding]; other site 41431005957 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431005958 nucleotide binding region [chemical binding]; other site 41431005959 ATP-binding site [chemical binding]; other site 41431005960 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431005961 putative active site [active] 41431005962 hypothetical protein; Validated; Region: PRK00110 41431005963 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 41431005964 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 41431005965 putative NADP binding site [chemical binding]; other site 41431005966 putative substrate binding site [chemical binding]; other site 41431005967 active site 41431005968 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 41431005969 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 41431005970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431005971 Walker A/P-loop; other site 41431005972 ATP binding site [chemical binding]; other site 41431005973 Q-loop/lid; other site 41431005974 ABC transporter signature motif; other site 41431005975 Walker B; other site 41431005976 D-loop; other site 41431005977 H-loop/switch region; other site 41431005978 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 41431005979 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 41431005980 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 41431005981 putative active site [active] 41431005982 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 41431005983 Peptidase family M50; Region: Peptidase_M50; pfam02163 41431005984 active site 41431005985 putative substrate binding region [chemical binding]; other site 41431005986 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 41431005987 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 41431005988 Methyltransferase domain; Region: Methyltransf_24; pfam13578 41431005989 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 41431005990 PhoH-like protein; Region: PhoH; pfam02562 41431005991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431005992 Methyltransferase domain; Region: Methyltransf_31; pfam13847 41431005993 S-adenosylmethionine binding site [chemical binding]; other site 41431005994 Response regulator receiver domain; Region: Response_reg; pfam00072 41431005995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431005996 active site 41431005997 phosphorylation site [posttranslational modification] 41431005998 intermolecular recognition site; other site 41431005999 dimerization interface [polypeptide binding]; other site 41431006000 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431006001 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431006002 metal binding site [ion binding]; metal-binding site 41431006003 active site 41431006004 I-site; other site 41431006005 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 41431006006 dimer interface [polypeptide binding]; other site 41431006007 substrate binding site [chemical binding]; other site 41431006008 metal binding sites [ion binding]; metal-binding site 41431006009 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 41431006010 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 41431006011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431006012 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431006013 Probable transposase; Region: OrfB_IS605; pfam01385 41431006014 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431006015 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 41431006016 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 41431006017 trimer interface [polypeptide binding]; other site 41431006018 active site 41431006019 substrate binding site [chemical binding]; other site 41431006020 CoA binding site [chemical binding]; other site 41431006021 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 41431006022 FAD binding site [chemical binding]; other site 41431006023 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 41431006024 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 41431006025 active site 41431006026 HIGH motif; other site 41431006027 dimer interface [polypeptide binding]; other site 41431006028 KMSKS motif; other site 41431006029 Response regulator receiver domain; Region: Response_reg; pfam00072 41431006030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006031 active site 41431006032 phosphorylation site [posttranslational modification] 41431006033 intermolecular recognition site; other site 41431006034 dimerization interface [polypeptide binding]; other site 41431006035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431006036 PAS domain; Region: PAS_9; pfam13426 41431006037 putative active site [active] 41431006038 heme pocket [chemical binding]; other site 41431006039 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431006040 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431006041 metal binding site [ion binding]; metal-binding site 41431006042 active site 41431006043 I-site; other site 41431006044 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 41431006045 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 41431006046 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 41431006047 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 41431006048 Moco binding site; other site 41431006049 metal coordination site [ion binding]; other site 41431006050 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 41431006051 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 41431006052 NAD binding site [chemical binding]; other site 41431006053 homotetramer interface [polypeptide binding]; other site 41431006054 homodimer interface [polypeptide binding]; other site 41431006055 substrate binding site [chemical binding]; other site 41431006056 active site 41431006057 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431006058 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 41431006059 ligand binding site [chemical binding]; other site 41431006060 flexible hinge region; other site 41431006061 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 41431006062 putative switch regulator; other site 41431006063 non-specific DNA interactions [nucleotide binding]; other site 41431006064 DNA binding site [nucleotide binding] 41431006065 sequence specific DNA binding site [nucleotide binding]; other site 41431006066 putative cAMP binding site [chemical binding]; other site 41431006067 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 41431006068 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 41431006069 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 41431006070 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 41431006071 Ligand binding site; other site 41431006072 Putative Catalytic site; other site 41431006073 DXD motif; other site 41431006074 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 41431006075 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431006076 substrate binding pocket [chemical binding]; other site 41431006077 membrane-bound complex binding site; other site 41431006078 hinge residues; other site 41431006079 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 41431006080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431006081 conserved gate region; other site 41431006082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431006083 putative PBP binding loops; other site 41431006084 dimer interface [polypeptide binding]; other site 41431006085 ABC-ATPase subunit interface; other site 41431006086 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 41431006087 B12 binding site [chemical binding]; other site 41431006088 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 41431006089 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431006090 FeS/SAM binding site; other site 41431006091 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 41431006092 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006093 putative active site [active] 41431006094 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 41431006095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 41431006096 Uncharacterized conserved protein [Function unknown]; Region: COG4278 41431006097 phycobillisome linker protein; Region: apcE; CHL00091 41431006098 Phycobilisome protein; Region: Phycobilisome; cl08227 41431006099 Phycobilisome protein; Region: Phycobilisome; cl08227 41431006100 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431006101 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431006102 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431006103 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 41431006104 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 41431006105 dimer interface [polypeptide binding]; other site 41431006106 catalytic residue [active] 41431006107 metal binding site [ion binding]; metal-binding site 41431006108 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 41431006109 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 41431006110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431006111 Walker A motif; other site 41431006112 ATP binding site [chemical binding]; other site 41431006113 Walker B motif; other site 41431006114 arginine finger; other site 41431006115 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 41431006116 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 41431006117 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 41431006118 putative metal binding site [ion binding]; other site 41431006119 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 41431006120 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 41431006121 putative metal binding site [ion binding]; other site 41431006122 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 41431006123 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 41431006124 putative metal binding site [ion binding]; other site 41431006125 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 41431006126 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 41431006127 active site 41431006128 Riboflavin kinase; Region: Flavokinase; pfam01687 41431006129 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 41431006130 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 41431006131 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431006132 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431006133 active site 41431006134 ATP binding site [chemical binding]; other site 41431006135 substrate binding site [chemical binding]; other site 41431006136 activation loop (A-loop); other site 41431006137 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 41431006138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431006139 S-adenosylmethionine binding site [chemical binding]; other site 41431006140 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250 41431006141 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 41431006142 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 41431006143 active site 41431006144 metal binding site [ion binding]; metal-binding site 41431006145 DNA binding site [nucleotide binding] 41431006146 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 41431006147 Protein of unknown function DUF58; Region: DUF58; pfam01882 41431006148 CHASE domain; Region: CHASE; pfam03924 41431006149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431006150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431006151 dimer interface [polypeptide binding]; other site 41431006152 phosphorylation site [posttranslational modification] 41431006153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431006154 ATP binding site [chemical binding]; other site 41431006155 Mg2+ binding site [ion binding]; other site 41431006156 G-X-G motif; other site 41431006157 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431006158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006159 active site 41431006160 phosphorylation site [posttranslational modification] 41431006161 intermolecular recognition site; other site 41431006162 dimerization interface [polypeptide binding]; other site 41431006163 PAS domain; Region: PAS_9; pfam13426 41431006164 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431006165 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431006166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431006167 dimer interface [polypeptide binding]; other site 41431006168 phosphorylation site [posttranslational modification] 41431006169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431006170 ATP binding site [chemical binding]; other site 41431006171 Mg2+ binding site [ion binding]; other site 41431006172 G-X-G motif; other site 41431006173 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 41431006174 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 41431006175 dimer interface [polypeptide binding]; other site 41431006176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431006177 catalytic residue [active] 41431006178 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 41431006179 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 41431006180 Sporulation and spore germination; Region: Germane; pfam10646 41431006181 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 41431006182 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 41431006183 active site 41431006184 trimer interface [polypeptide binding]; other site 41431006185 allosteric site; other site 41431006186 active site lid [active] 41431006187 hexamer (dimer of trimers) interface [polypeptide binding]; other site 41431006188 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 41431006189 GSH binding site [chemical binding]; other site 41431006190 catalytic residues [active] 41431006191 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 41431006192 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 41431006193 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 41431006194 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 41431006195 Cytochrome c; Region: Cytochrom_C; pfam00034 41431006196 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 41431006197 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 41431006198 NADP-binding site; other site 41431006199 homotetramer interface [polypeptide binding]; other site 41431006200 substrate binding site [chemical binding]; other site 41431006201 homodimer interface [polypeptide binding]; other site 41431006202 active site 41431006203 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 41431006204 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 41431006205 active site 41431006206 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431006207 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 41431006208 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 41431006209 active site 41431006210 catalytic site [active] 41431006211 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 41431006212 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 41431006213 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 41431006214 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 41431006215 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 41431006216 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 41431006217 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 41431006218 active site 41431006219 dimer interface [polypeptide binding]; other site 41431006220 catalytic residue [active] 41431006221 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 41431006222 Ca2+ binding site [ion binding]; other site 41431006223 Membrane protein of unknown function; Region: DUF360; pfam04020 41431006224 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 41431006225 OstA-like protein; Region: OstA; pfam03968 41431006226 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 41431006227 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 41431006228 Walker A/P-loop; other site 41431006229 ATP binding site [chemical binding]; other site 41431006230 Q-loop/lid; other site 41431006231 ABC transporter signature motif; other site 41431006232 Walker B; other site 41431006233 D-loop; other site 41431006234 H-loop/switch region; other site 41431006235 Predicted permeases [General function prediction only]; Region: COG0795 41431006236 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 41431006237 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 41431006238 catalytic triad [active] 41431006239 Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865 41431006240 Protein-arginine deiminase (PAD) middle domain; Region: PAD_M; pfam08527 41431006241 Protein-arginine deiminase (PAD); Region: PAD; pfam03068 41431006242 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 41431006243 Predicted membrane protein [Function unknown]; Region: COG3463 41431006244 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 41431006245 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 41431006246 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 41431006247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431006248 NAD(P) binding site [chemical binding]; other site 41431006249 active site 41431006250 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 41431006251 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 41431006252 C-terminal domain interface [polypeptide binding]; other site 41431006253 GSH binding site (G-site) [chemical binding]; other site 41431006254 dimer interface [polypeptide binding]; other site 41431006255 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 41431006256 N-terminal domain interface [polypeptide binding]; other site 41431006257 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431006258 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431006259 structural tetrad; other site 41431006260 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 41431006261 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 41431006262 acyl-activating enzyme (AAE) consensus motif; other site 41431006263 active site 41431006264 AMP binding site [chemical binding]; other site 41431006265 CoA binding site [chemical binding]; other site 41431006266 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 41431006267 starch-binding site 2 [chemical binding]; other site 41431006268 starch-binding site 1 [chemical binding]; other site 41431006269 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 41431006270 active site 41431006271 catalytic triad [active] 41431006272 oxyanion hole [active] 41431006273 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 41431006274 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 41431006275 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 41431006276 trimerization site [polypeptide binding]; other site 41431006277 active site 41431006278 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 41431006279 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 41431006280 Ligand binding site; other site 41431006281 metal-binding site 41431006282 HEPN domain; Region: HEPN; cl00824 41431006283 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 41431006284 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 41431006285 Cytochrome P450; Region: p450; pfam00067 41431006286 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 41431006287 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 41431006288 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431006289 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 41431006290 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 41431006291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431006292 FeS/SAM binding site; other site 41431006293 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 41431006294 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 41431006295 active site 41431006296 metal binding site [ion binding]; metal-binding site 41431006297 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 41431006298 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 41431006299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431006300 binding surface 41431006301 TPR motif; other site 41431006302 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 41431006303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431006304 S-adenosylmethionine binding site [chemical binding]; other site 41431006305 sulfotransferase; Region: PLN02164 41431006306 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 41431006307 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 41431006308 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 41431006309 dimer interface [polypeptide binding]; other site 41431006310 PYR/PP interface [polypeptide binding]; other site 41431006311 TPP binding site [chemical binding]; other site 41431006312 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 41431006313 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 41431006314 TPP-binding site [chemical binding]; other site 41431006315 dimer interface [polypeptide binding]; other site 41431006316 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431006317 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006318 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006319 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006320 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006321 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431006322 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431006323 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431006324 metal binding site [ion binding]; metal-binding site 41431006325 active site 41431006326 I-site; other site 41431006327 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 41431006328 NAD(P) binding pocket [chemical binding]; other site 41431006329 MASE1; Region: MASE1; pfam05231 41431006330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431006331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431006332 dimer interface [polypeptide binding]; other site 41431006333 phosphorylation site [posttranslational modification] 41431006334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431006335 ATP binding site [chemical binding]; other site 41431006336 Mg2+ binding site [ion binding]; other site 41431006337 G-X-G motif; other site 41431006338 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431006339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006340 active site 41431006341 phosphorylation site [posttranslational modification] 41431006342 intermolecular recognition site; other site 41431006343 dimerization interface [polypeptide binding]; other site 41431006344 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 41431006345 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 41431006346 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 41431006347 active site 41431006348 dimer interface [polypeptide binding]; other site 41431006349 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 41431006350 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 41431006351 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 41431006352 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 41431006353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431006354 dimer interface [polypeptide binding]; other site 41431006355 conserved gate region; other site 41431006356 putative PBP binding loops; other site 41431006357 ABC-ATPase subunit interface; other site 41431006358 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 41431006359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431006360 Walker A/P-loop; other site 41431006361 ATP binding site [chemical binding]; other site 41431006362 Q-loop/lid; other site 41431006363 ABC transporter signature motif; other site 41431006364 Walker B; other site 41431006365 D-loop; other site 41431006366 H-loop/switch region; other site 41431006367 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 41431006368 SmpB-tmRNA interface; other site 41431006369 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 41431006370 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 41431006371 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 41431006372 Peptidase family M23; Region: Peptidase_M23; pfam01551 41431006373 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 41431006374 Beta-lactamase; Region: Beta-lactamase; pfam00144 41431006375 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 41431006376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431006377 Coenzyme A binding pocket [chemical binding]; other site 41431006378 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 41431006379 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 41431006380 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 41431006381 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 41431006382 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 41431006383 Walker A/P-loop; other site 41431006384 ATP binding site [chemical binding]; other site 41431006385 Q-loop/lid; other site 41431006386 ABC transporter signature motif; other site 41431006387 Walker B; other site 41431006388 D-loop; other site 41431006389 H-loop/switch region; other site 41431006390 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431006391 Ligand Binding Site [chemical binding]; other site 41431006392 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431006393 Ligand Binding Site [chemical binding]; other site 41431006394 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 41431006395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431006396 Probable transposase; Region: OrfB_IS605; pfam01385 41431006397 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431006398 SOS regulatory protein LexA; Region: lexA; TIGR00498 41431006399 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 41431006400 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 41431006401 Catalytic site [active] 41431006402 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 41431006403 active site 41431006404 dinuclear metal binding site [ion binding]; other site 41431006405 dimerization interface [polypeptide binding]; other site 41431006406 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 41431006407 active site 41431006408 multimer interface [polypeptide binding]; other site 41431006409 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 41431006410 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 41431006411 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431006412 active site 41431006413 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431006414 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 41431006415 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 41431006416 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 41431006417 Ligand binding site; other site 41431006418 metal-binding site 41431006419 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 41431006420 HAS barrel domain; Region: HAS-barrel; pfam09378 41431006421 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 41431006422 methionine sulfoxide reductase A; Provisional; Region: PRK00058 41431006423 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006424 putative active site [active] 41431006425 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 41431006426 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 41431006427 Protein of unknown function, DUF608; Region: DUF608; pfam04685 41431006428 dihydroorotase; Provisional; Region: PRK07369 41431006429 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 41431006430 active site 41431006431 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 41431006432 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 41431006433 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 41431006434 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 41431006435 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 41431006436 Peptidase family M23; Region: Peptidase_M23; pfam01551 41431006437 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 41431006438 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 41431006439 DNA binding residues [nucleotide binding] 41431006440 putative dimer interface [polypeptide binding]; other site 41431006441 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 41431006442 HsdM N-terminal domain; Region: HsdM_N; pfam12161 41431006443 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 41431006444 putative active site [active] 41431006445 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 41431006446 YcfA-like protein; Region: YcfA; pfam07927 41431006447 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431006448 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 41431006449 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431006450 PIN domain; Region: PIN_3; cl17397 41431006451 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 41431006452 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 41431006453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431006454 ATP binding site [chemical binding]; other site 41431006455 putative Mg++ binding site [ion binding]; other site 41431006456 Protein of unknown function DUF45; Region: DUF45; pfam01863 41431006457 TIGR04255 family protein; Region: sporadTIGR04255 41431006458 Winged helix-turn helix; Region: HTH_29; pfam13551 41431006459 Helix-turn-helix domain; Region: HTH_28; pfam13518 41431006460 Homeodomain-like domain; Region: HTH_32; pfam13565 41431006461 Dynamin family; Region: Dynamin_N; pfam00350 41431006462 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 41431006463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431006464 dimer interface [polypeptide binding]; other site 41431006465 conserved gate region; other site 41431006466 putative PBP binding loops; other site 41431006467 ABC-ATPase subunit interface; other site 41431006468 phosphatidate cytidylyltransferase; Region: PLN02953 41431006469 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 41431006470 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006471 putative active site [active] 41431006472 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 41431006473 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431006474 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431006475 active site 41431006476 ATP binding site [chemical binding]; other site 41431006477 substrate binding site [chemical binding]; other site 41431006478 activation loop (A-loop); other site 41431006479 aspartate aminotransferase; Provisional; Region: PRK05942 41431006480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431006481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431006482 homodimer interface [polypeptide binding]; other site 41431006483 catalytic residue [active] 41431006484 plastocyanin; Provisional; Region: PRK02710 41431006485 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 41431006486 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 41431006487 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 41431006488 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 41431006489 Protein of unknown function (DUF512); Region: DUF512; pfam04459 41431006490 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 41431006491 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 41431006492 Walker A/P-loop; other site 41431006493 ATP binding site [chemical binding]; other site 41431006494 Q-loop/lid; other site 41431006495 ABC transporter signature motif; other site 41431006496 Walker B; other site 41431006497 D-loop; other site 41431006498 H-loop/switch region; other site 41431006499 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 41431006500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 41431006501 non-specific DNA binding site [nucleotide binding]; other site 41431006502 salt bridge; other site 41431006503 sequence-specific DNA binding site [nucleotide binding]; other site 41431006504 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 41431006505 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 41431006506 Sulfate transporter family; Region: Sulfate_transp; pfam00916 41431006507 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 41431006508 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 41431006509 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 41431006510 domain interfaces; other site 41431006511 active site 41431006512 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 41431006513 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 41431006514 putative ligand binding site [chemical binding]; other site 41431006515 putative NAD binding site [chemical binding]; other site 41431006516 catalytic site [active] 41431006517 hydrolase, alpha/beta fold family protein; Region: PLN02824 41431006518 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 41431006519 HupF/HypC family; Region: HupF_HypC; pfam01455 41431006520 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 41431006521 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 41431006522 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 41431006523 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 41431006524 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 41431006525 diiron binding motif [ion binding]; other site 41431006526 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 41431006527 active site 41431006528 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 41431006529 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 41431006530 phosphoglyceromutase; Provisional; Region: PRK05434 41431006531 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 41431006532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431006533 dimer interface [polypeptide binding]; other site 41431006534 conserved gate region; other site 41431006535 putative PBP binding loops; other site 41431006536 ABC-ATPase subunit interface; other site 41431006537 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006538 putative active site [active] 41431006539 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 41431006540 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 41431006541 conserved cys residue [active] 41431006542 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 41431006543 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 41431006544 peptide binding site [polypeptide binding]; other site 41431006545 dimer interface [polypeptide binding]; other site 41431006546 TIR domain; Region: TIR_2; pfam13676 41431006547 GUN4-like; Region: GUN4; pfam05419 41431006548 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 41431006549 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 41431006550 glutamine binding [chemical binding]; other site 41431006551 catalytic triad [active] 41431006552 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 41431006553 metal-binding heat shock protein; Provisional; Region: PRK00016 41431006554 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 41431006555 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 41431006556 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 41431006557 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 41431006558 active site 41431006559 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 41431006560 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 41431006561 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 41431006562 Walker A/P-loop; other site 41431006563 ATP binding site [chemical binding]; other site 41431006564 Q-loop/lid; other site 41431006565 ABC transporter signature motif; other site 41431006566 Walker B; other site 41431006567 D-loop; other site 41431006568 H-loop/switch region; other site 41431006569 TOBE domain; Region: TOBE_2; pfam08402 41431006570 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 41431006571 active site 41431006572 oxyanion hole [active] 41431006573 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 41431006574 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 41431006575 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 41431006576 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 41431006577 16S/18S rRNA binding site [nucleotide binding]; other site 41431006578 S13e-L30e interaction site [polypeptide binding]; other site 41431006579 25S rRNA binding site [nucleotide binding]; other site 41431006580 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431006581 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431006582 active site 41431006583 ATP binding site [chemical binding]; other site 41431006584 substrate binding site [chemical binding]; other site 41431006585 activation loop (A-loop); other site 41431006586 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 41431006587 active site 41431006588 SAM binding site [chemical binding]; other site 41431006589 homodimer interface [polypeptide binding]; other site 41431006590 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 41431006591 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 41431006592 putative active site [active] 41431006593 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 41431006594 putative active site [active] 41431006595 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 41431006596 4Fe-4S binding domain; Region: Fer4; pfam00037 41431006597 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 41431006598 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 41431006599 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 41431006600 catalytic residues [active] 41431006601 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 41431006602 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 41431006603 active site 41431006604 dimer interface [polypeptide binding]; other site 41431006605 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 41431006606 active site 41431006607 cytochrome c biogenesis protein; Region: ccsA; CHL00045 41431006608 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 41431006609 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 41431006610 Uncharacterized conserved protein [Function unknown]; Region: COG1479 41431006611 Protein of unknown function DUF262; Region: DUF262; pfam03235 41431006612 Ycf27; Reviewed; Region: orf27; CHL00148 41431006613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006614 active site 41431006615 phosphorylation site [posttranslational modification] 41431006616 intermolecular recognition site; other site 41431006617 dimerization interface [polypeptide binding]; other site 41431006618 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431006619 DNA binding site [nucleotide binding] 41431006620 DNA repair protein RadA; Provisional; Region: PRK11823 41431006621 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 41431006622 Walker A motif/ATP binding site; other site 41431006623 ATP binding site [chemical binding]; other site 41431006624 Walker B motif; other site 41431006625 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 41431006626 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431006627 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006628 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006629 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431006630 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006631 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431006632 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 41431006633 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 41431006634 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 41431006635 HIGH motif; other site 41431006636 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 41431006637 active site 41431006638 KMSKS motif; other site 41431006639 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 41431006640 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 41431006641 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 41431006642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431006643 Walker A/P-loop; other site 41431006644 ATP binding site [chemical binding]; other site 41431006645 Q-loop/lid; other site 41431006646 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 41431006647 ABC transporter signature motif; other site 41431006648 Walker B; other site 41431006649 D-loop; other site 41431006650 ABC transporter; Region: ABC_tran_2; pfam12848 41431006651 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 41431006652 ABC transporter; Region: ABC_tran_2; pfam12848 41431006653 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431006654 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 41431006655 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 41431006656 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431006657 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 41431006658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431006659 active site 41431006660 motif I; other site 41431006661 motif II; other site 41431006662 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 41431006663 dimer interface [polypeptide binding]; other site 41431006664 active site 41431006665 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431006666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431006667 NAD(P) binding site [chemical binding]; other site 41431006668 active site 41431006669 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 41431006670 arsenical-resistance protein; Region: acr3; TIGR00832 41431006671 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 41431006672 dimerization interface [polypeptide binding]; other site 41431006673 putative DNA binding site [nucleotide binding]; other site 41431006674 putative Zn2+ binding site [ion binding]; other site 41431006675 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 41431006676 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 41431006677 putative NAD(P) binding site [chemical binding]; other site 41431006678 catalytic Zn binding site [ion binding]; other site 41431006679 structural Zn binding site [ion binding]; other site 41431006680 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431006681 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 41431006682 active site 41431006683 metal binding site [ion binding]; metal-binding site 41431006684 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 41431006685 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431006686 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 41431006687 diaminopimelate epimerase; Region: PLN02536 41431006688 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 41431006689 S-layer homology domain; Region: SLH; pfam00395 41431006690 S-layer homology domain; Region: SLH; pfam00395 41431006691 S-layer homology domain; Region: SLH; pfam00395 41431006692 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 41431006693 Transcriptional regulator [Transcription]; Region: LysR; COG0583 41431006694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 41431006695 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 41431006696 dimerization interface [polypeptide binding]; other site 41431006697 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431006698 Ligand Binding Site [chemical binding]; other site 41431006699 aspartate aminotransferase; Provisional; Region: PRK05764 41431006700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431006701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431006702 homodimer interface [polypeptide binding]; other site 41431006703 catalytic residue [active] 41431006704 Protein of unknown function (DUF561); Region: DUF561; pfam04481 41431006705 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 41431006706 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 41431006707 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 41431006708 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 41431006709 homodimer interface [polypeptide binding]; other site 41431006710 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 41431006711 active site pocket [active] 41431006712 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 41431006713 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 41431006714 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 41431006715 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 41431006716 homodimer interface [polypeptide binding]; other site 41431006717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431006718 catalytic residue [active] 41431006719 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 41431006720 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431006721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006722 active site 41431006723 phosphorylation site [posttranslational modification] 41431006724 intermolecular recognition site; other site 41431006725 dimerization interface [polypeptide binding]; other site 41431006726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431006727 DNA binding site [nucleotide binding] 41431006728 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 41431006729 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 41431006730 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 41431006731 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 41431006732 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 41431006733 G1 box; other site 41431006734 GTP/Mg2+ binding site [chemical binding]; other site 41431006735 Switch I region; other site 41431006736 G2 box; other site 41431006737 Switch II region; other site 41431006738 G3 box; other site 41431006739 G4 box; other site 41431006740 G5 box; other site 41431006741 Domain of unknown function (DUF697); Region: DUF697; pfam05128 41431006742 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 41431006743 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 41431006744 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 41431006745 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 41431006746 catalytic residues [active] 41431006747 Helix-turn-helix domain; Region: HTH_18; pfam12833 41431006748 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 41431006749 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 41431006750 DNA binding site [nucleotide binding] 41431006751 active site 41431006752 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 41431006753 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 41431006754 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 41431006755 nudix motif; other site 41431006756 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 41431006757 dimer interface [polypeptide binding]; other site 41431006758 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431006759 metal binding site [ion binding]; metal-binding site 41431006760 glycogen branching enzyme; Provisional; Region: PRK12313 41431006761 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 41431006762 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 41431006763 active site 41431006764 catalytic site [active] 41431006765 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 41431006766 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 41431006767 dihydropteroate synthase; Region: DHPS; TIGR01496 41431006768 substrate binding pocket [chemical binding]; other site 41431006769 dimer interface [polypeptide binding]; other site 41431006770 inhibitor binding site; inhibition site 41431006771 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 41431006772 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 41431006773 minor groove reading motif; other site 41431006774 helix-hairpin-helix signature motif; other site 41431006775 substrate binding pocket [chemical binding]; other site 41431006776 active site 41431006777 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 41431006778 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 41431006779 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 41431006780 active site 41431006781 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 41431006782 protein binding site [polypeptide binding]; other site 41431006783 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 41431006784 2TM domain; Region: 2TM; pfam13239 41431006785 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 41431006786 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 41431006787 putative substrate binding site [chemical binding]; other site 41431006788 nucleotide binding site [chemical binding]; other site 41431006789 nucleotide binding site [chemical binding]; other site 41431006790 homodimer interface [polypeptide binding]; other site 41431006791 Predicted GTPase [General function prediction only]; Region: COG2403 41431006792 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 41431006793 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 41431006794 active site 41431006795 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 41431006796 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 41431006797 inhibitor-cofactor binding pocket; inhibition site 41431006798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431006799 catalytic residue [active] 41431006800 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 41431006801 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 41431006802 active site residue [active] 41431006803 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 41431006804 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 41431006805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431006806 Coenzyme A binding pocket [chemical binding]; other site 41431006807 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 41431006808 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 41431006809 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 41431006810 homotetramer interface [polypeptide binding]; other site 41431006811 ligand binding site [chemical binding]; other site 41431006812 catalytic site [active] 41431006813 NAD binding site [chemical binding]; other site 41431006814 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 41431006815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006816 active site 41431006817 phosphorylation site [posttranslational modification] 41431006818 intermolecular recognition site; other site 41431006819 dimerization interface [polypeptide binding]; other site 41431006820 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431006821 DNA binding residues [nucleotide binding] 41431006822 dimerization interface [polypeptide binding]; other site 41431006823 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 41431006824 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 41431006825 FMN binding site [chemical binding]; other site 41431006826 active site 41431006827 catalytic residues [active] 41431006828 substrate binding site [chemical binding]; other site 41431006829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 41431006830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 41431006831 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 41431006832 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 41431006833 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 41431006834 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 41431006835 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431006836 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 41431006837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431006838 S-adenosylmethionine binding site [chemical binding]; other site 41431006839 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 41431006840 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 41431006841 ligand binding site [chemical binding]; other site 41431006842 NAD binding site [chemical binding]; other site 41431006843 dimerization interface [polypeptide binding]; other site 41431006844 catalytic site [active] 41431006845 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 41431006846 putative L-serine binding site [chemical binding]; other site 41431006847 TIR domain; Region: TIR_2; pfam13676 41431006848 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431006849 WD40 repeats; Region: WD40; smart00320 41431006850 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431006851 structural tetrad; other site 41431006852 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431006853 structural tetrad; other site 41431006854 WD40 repeats; Region: WD40; smart00320 41431006855 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 41431006856 Methyltransferase domain; Region: Methyltransf_23; pfam13489 41431006857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431006858 S-adenosylmethionine binding site [chemical binding]; other site 41431006859 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 41431006860 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 41431006861 active site flap/lid [active] 41431006862 nucleophilic elbow; other site 41431006863 catalytic triad [active] 41431006864 Caspase domain; Region: Peptidase_C14; pfam00656 41431006865 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 41431006866 classical (c) SDRs; Region: SDR_c; cd05233 41431006867 NAD(P) binding site [chemical binding]; other site 41431006868 active site 41431006869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431006870 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431006871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 41431006872 conserved hypothetical protein; Region: TIGR03492 41431006873 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006874 putative active site [active] 41431006875 LTXXQ motif family protein; Region: LTXXQ; pfam07813 41431006876 dimer interface [polypeptide binding]; other site 41431006877 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 41431006878 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 41431006879 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 41431006880 Walker A/P-loop; other site 41431006881 ATP binding site [chemical binding]; other site 41431006882 Q-loop/lid; other site 41431006883 ABC transporter signature motif; other site 41431006884 Walker B; other site 41431006885 D-loop; other site 41431006886 H-loop/switch region; other site 41431006887 cytochrome b6-f complex subunit PetN; Provisional; Region: PRK14747 41431006888 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 41431006889 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 41431006890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431006891 Walker A/P-loop; other site 41431006892 ATP binding site [chemical binding]; other site 41431006893 14-3-3 domain; Region: 14-3-3; cl02098 41431006894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431006895 Q-loop/lid; other site 41431006896 ABC transporter signature motif; other site 41431006897 Walker B; other site 41431006898 D-loop; other site 41431006899 H-loop/switch region; other site 41431006900 hypothetical protein; Provisional; Region: PRK06850 41431006901 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 41431006902 Active Sites [active] 41431006903 DNA-sulfur modification-associated; Region: DndB; pfam14072 41431006904 DGQHR domain; Region: DGQHR; TIGR03187 41431006905 DNA-sulfur modification-associated; Region: DndB; cl17621 41431006906 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431006907 putative active site [active] 41431006908 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 41431006909 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 41431006910 phosphate binding site [ion binding]; other site 41431006911 putative substrate binding pocket [chemical binding]; other site 41431006912 dimer interface [polypeptide binding]; other site 41431006913 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 41431006914 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 41431006915 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 41431006916 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 41431006917 N-acetyl-D-glucosamine binding site [chemical binding]; other site 41431006918 catalytic residue [active] 41431006919 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 41431006920 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 41431006921 endonuclease III; Region: ENDO3c; smart00478 41431006922 minor groove reading motif; other site 41431006923 helix-hairpin-helix signature motif; other site 41431006924 substrate binding pocket [chemical binding]; other site 41431006925 active site 41431006926 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 41431006927 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 41431006928 putative acyl-acceptor binding pocket; other site 41431006929 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 41431006930 hypothetical protein; Provisional; Region: PRK04194 41431006931 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 41431006932 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 41431006933 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 41431006934 HAS barrel domain; Region: HAS-barrel; pfam09378 41431006935 HerA helicase [Replication, recombination, and repair]; Region: COG0433 41431006936 Domain of unknown function DUF87; Region: DUF87; pfam01935 41431006937 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 41431006938 dimer interface [polypeptide binding]; other site 41431006939 [2Fe-2S] cluster binding site [ion binding]; other site 41431006940 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398 41431006941 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 41431006942 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431006943 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431006944 active site 41431006945 ATP binding site [chemical binding]; other site 41431006946 substrate binding site [chemical binding]; other site 41431006947 activation loop (A-loop); other site 41431006948 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 41431006949 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 41431006950 anti sigma factor interaction site; other site 41431006951 regulatory phosphorylation site [posttranslational modification]; other site 41431006952 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 41431006953 dimerization interface [polypeptide binding]; other site 41431006954 active site 41431006955 metal binding site [ion binding]; metal-binding site 41431006956 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 41431006957 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 41431006958 active site 41431006959 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 41431006960 active site 41431006961 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 41431006962 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 41431006963 active site 41431006964 PHP Thumb interface [polypeptide binding]; other site 41431006965 metal binding site [ion binding]; metal-binding site 41431006966 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 41431006967 protein-splicing catalytic site; other site 41431006968 thioester formation/cholesterol transfer; other site 41431006969 Sm and related proteins; Region: Sm_like; cl00259 41431006970 heptamer interface [polypeptide binding]; other site 41431006971 Sm1 motif; other site 41431006972 hexamer interface [polypeptide binding]; other site 41431006973 RNA binding site [nucleotide binding]; other site 41431006974 Sm2 motif; other site 41431006975 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 41431006976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431006977 active site 41431006978 phosphorylation site [posttranslational modification] 41431006979 intermolecular recognition site; other site 41431006980 dimerization interface [polypeptide binding]; other site 41431006981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431006982 DNA binding residues [nucleotide binding] 41431006983 dimerization interface [polypeptide binding]; other site 41431006984 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 41431006985 Domain of unknown function DUF21; Region: DUF21; pfam01595 41431006986 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 41431006987 Transporter associated domain; Region: CorC_HlyC; smart01091 41431006988 Penicillin amidase; Region: Penicil_amidase; pfam01804 41431006989 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 41431006990 active site 41431006991 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 41431006992 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 41431006993 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 41431006994 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 41431006995 Cytochrome P450; Region: p450; cl12078 41431006996 Lipoxygenase; Region: Lipoxygenase; pfam00305 41431006997 Protein of unknown function (DUF497); Region: DUF497; pfam04365 41431006998 Nuclease-related domain; Region: NERD; pfam08378 41431006999 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 41431007000 Family description; Region: UvrD_C_2; pfam13538 41431007001 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431007002 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007003 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007004 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 41431007005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431007006 Coenzyme A binding pocket [chemical binding]; other site 41431007007 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 41431007008 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 41431007009 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 41431007010 active site 41431007011 catalytic site [active] 41431007012 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 41431007013 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 41431007014 Ion transport protein; Region: Ion_trans; pfam00520 41431007015 Ion channel; Region: Ion_trans_2; pfam07885 41431007016 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 41431007017 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007018 putative active site [active] 41431007019 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 41431007020 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 41431007021 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 41431007022 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 41431007023 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 41431007024 dimerization interface [polypeptide binding]; other site 41431007025 DPS ferroxidase diiron center [ion binding]; other site 41431007026 ion pore; other site 41431007027 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 41431007028 dimer interface [polypeptide binding]; other site 41431007029 [2Fe-2S] cluster binding site [ion binding]; other site 41431007030 Predicted membrane protein [Function unknown]; Region: COG1971 41431007031 Domain of unknown function DUF; Region: DUF204; pfam02659 41431007032 Domain of unknown function DUF; Region: DUF204; pfam02659 41431007033 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431007034 Ligand Binding Site [chemical binding]; other site 41431007035 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431007036 Ligand Binding Site [chemical binding]; other site 41431007037 Protein kinase domain; Region: Pkinase; pfam00069 41431007038 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431007039 active site 41431007040 ATP binding site [chemical binding]; other site 41431007041 substrate binding site [chemical binding]; other site 41431007042 activation loop (A-loop); other site 41431007043 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 41431007044 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 41431007045 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 41431007046 putative valine binding site [chemical binding]; other site 41431007047 dimer interface [polypeptide binding]; other site 41431007048 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 41431007049 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007050 putative active site [active] 41431007051 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 41431007052 Microvirus H protein (pilot protein); Region: Microvir_H; cl11620 41431007053 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431007054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 41431007055 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 41431007056 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 41431007057 [4Fe-4S] binding site [ion binding]; other site 41431007058 molybdopterin cofactor binding site; other site 41431007059 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 41431007060 molybdopterin cofactor binding site; other site 41431007061 AAA domain; Region: AAA_17; pfam13207 41431007062 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007063 putative active site [active] 41431007064 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431007065 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431007066 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 41431007067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431007068 putative substrate translocation pore; other site 41431007069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431007070 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 41431007071 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 41431007072 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 41431007073 HEAT repeats; Region: HEAT_2; pfam13646 41431007074 HEAT repeats; Region: HEAT_2; pfam13646 41431007075 HEAT repeats; Region: HEAT_2; pfam13646 41431007076 hypothetical protein; Provisional; Region: PRK07394 41431007077 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 41431007078 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 41431007079 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 41431007080 homopentamer interface [polypeptide binding]; other site 41431007081 active site 41431007082 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 41431007083 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 41431007084 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 41431007085 C-terminal domain interface [polypeptide binding]; other site 41431007086 GSH binding site (G-site) [chemical binding]; other site 41431007087 dimer interface [polypeptide binding]; other site 41431007088 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 41431007089 N-terminal domain interface [polypeptide binding]; other site 41431007090 dimer interface [polypeptide binding]; other site 41431007091 substrate binding pocket (H-site) [chemical binding]; other site 41431007092 Uncharacterized conserved protein [Function unknown]; Region: COG2912 41431007093 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 41431007094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431007095 binding surface 41431007096 TPR motif; other site 41431007097 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 41431007098 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 41431007099 active site 41431007100 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 41431007101 Zn binding site [ion binding]; other site 41431007102 toxin interface [polypeptide binding]; other site 41431007103 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 41431007104 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 41431007105 TIR domain; Region: TIR_2; pfam13676 41431007106 Uncharacterized conserved protein [Function unknown]; Region: COG1262 41431007107 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 41431007108 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 41431007109 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 41431007110 [2Fe-2S] cluster binding site [ion binding]; other site 41431007111 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 41431007112 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 41431007113 metal binding site [ion binding]; metal-binding site 41431007114 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 41431007115 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 41431007116 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 41431007117 YcfA-like protein; Region: YcfA; pfam07927 41431007118 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 41431007119 TPR repeat; Region: TPR_11; pfam13414 41431007120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431007121 binding surface 41431007122 TPR motif; other site 41431007123 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431007124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431007125 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431007126 binding surface 41431007127 TPR motif; other site 41431007128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 41431007129 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 41431007130 Uncharacterized conserved protein [Function unknown]; Region: COG5607 41431007131 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 41431007132 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 41431007133 active site 41431007134 putative lithium-binding site [ion binding]; other site 41431007135 substrate binding site [chemical binding]; other site 41431007136 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 41431007137 DHH family; Region: DHH; pfam01368 41431007138 DHHA1 domain; Region: DHHA1; pfam02272 41431007139 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 41431007140 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 41431007141 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 41431007142 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 41431007143 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 41431007144 substrate binding pocket [chemical binding]; other site 41431007145 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 41431007146 B12 binding site [chemical binding]; other site 41431007147 cobalt ligand [ion binding]; other site 41431007148 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 41431007149 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 41431007150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431007151 S-adenosylmethionine binding site [chemical binding]; other site 41431007152 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 41431007153 hydrophobic ligand binding site; other site 41431007154 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431007155 dephospho-CoA kinase; Region: TIGR00152 41431007156 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 41431007157 CoA-binding site [chemical binding]; other site 41431007158 ATP-binding [chemical binding]; other site 41431007159 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 41431007160 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 41431007161 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 41431007162 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 41431007163 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 41431007164 TPP-binding site [chemical binding]; other site 41431007165 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 41431007166 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431007167 active site 41431007168 ATP binding site [chemical binding]; other site 41431007169 substrate binding site [chemical binding]; other site 41431007170 activation loop (A-loop); other site 41431007171 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431007172 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007173 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007174 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431007175 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 41431007176 cofactor binding site; other site 41431007177 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431007178 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 41431007179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431007180 dimer interface [polypeptide binding]; other site 41431007181 ABC-ATPase subunit interface; other site 41431007182 putative PBP binding loops; other site 41431007183 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 41431007184 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 41431007185 inhibitor-cofactor binding pocket; inhibition site 41431007186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431007187 catalytic residue [active] 41431007188 cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156 41431007189 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 41431007190 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 41431007191 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 41431007192 SLBB domain; Region: SLBB; pfam10531 41431007193 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 41431007194 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 41431007195 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 41431007196 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007197 putative active site [active] 41431007198 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 41431007199 catalytic core [active] 41431007200 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 41431007201 catalytic core [active] 41431007202 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 41431007203 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 41431007204 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 41431007205 CAAX protease self-immunity; Region: Abi; pfam02517 41431007206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431007207 TPR motif; other site 41431007208 binding surface 41431007209 Predicted integral membrane protein [Function unknown]; Region: COG0762 41431007210 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 41431007211 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 41431007212 Domain of unknown function DUF20; Region: UPF0118; pfam01594 41431007213 Transcriptional regulator [Transcription]; Region: LytR; COG1316 41431007214 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 41431007215 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431007216 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007217 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007218 2TM domain; Region: 2TM; pfam13239 41431007219 Domain of unknown function (DUF697); Region: DUF697; pfam05128 41431007220 GTP-binding protein LepA; Provisional; Region: PRK05433 41431007221 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 41431007222 G1 box; other site 41431007223 putative GEF interaction site [polypeptide binding]; other site 41431007224 GTP/Mg2+ binding site [chemical binding]; other site 41431007225 Switch I region; other site 41431007226 G2 box; other site 41431007227 G3 box; other site 41431007228 Switch II region; other site 41431007229 G4 box; other site 41431007230 G5 box; other site 41431007231 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 41431007232 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 41431007233 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 41431007234 TPR repeat; Region: TPR_11; pfam13414 41431007235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431007236 binding surface 41431007237 TPR motif; other site 41431007238 TPR repeat; Region: TPR_11; pfam13414 41431007239 TPR repeat; Region: TPR_11; pfam13414 41431007240 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431007241 PsbP; Region: PsbP; pfam01789 41431007242 Maf-like protein; Region: Maf; pfam02545 41431007243 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 41431007244 active site 41431007245 dimer interface [polypeptide binding]; other site 41431007246 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 41431007247 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 41431007248 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 41431007249 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 41431007250 homodimer interface [polypeptide binding]; other site 41431007251 Walker A motif; other site 41431007252 ATP binding site [chemical binding]; other site 41431007253 hydroxycobalamin binding site [chemical binding]; other site 41431007254 Walker B motif; other site 41431007255 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007256 putative active site [active] 41431007257 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 41431007258 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 41431007259 RNA polymerase sigma factor; Validated; Region: PRK05949 41431007260 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 41431007261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431007262 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431007263 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431007264 DNA binding residues [nucleotide binding] 41431007265 Domain of unknown function DUF39; Region: DUF39; pfam01837 41431007266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 41431007267 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 41431007268 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 41431007269 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 41431007270 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 41431007271 dimerization interface [polypeptide binding]; other site 41431007272 FAD binding pocket [chemical binding]; other site 41431007273 FAD binding motif [chemical binding]; other site 41431007274 catalytic residues [active] 41431007275 NAD binding pocket [chemical binding]; other site 41431007276 phosphate binding motif [ion binding]; other site 41431007277 beta-alpha-beta structure motif; other site 41431007278 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 41431007279 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 41431007280 putative active site [active] 41431007281 putative metal binding residues [ion binding]; other site 41431007282 signature motif; other site 41431007283 putative dimer interface [polypeptide binding]; other site 41431007284 putative phosphate binding site [ion binding]; other site 41431007285 GTPase Era; Reviewed; Region: era; PRK00089 41431007286 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 41431007287 G1 box; other site 41431007288 GTP/Mg2+ binding site [chemical binding]; other site 41431007289 Switch I region; other site 41431007290 G2 box; other site 41431007291 Switch II region; other site 41431007292 G3 box; other site 41431007293 G4 box; other site 41431007294 G5 box; other site 41431007295 KH domain; Region: KH_2; pfam07650 41431007296 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 41431007297 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 41431007298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431007299 ATP binding site [chemical binding]; other site 41431007300 Mg2+ binding site [ion binding]; other site 41431007301 G-X-G motif; other site 41431007302 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 41431007303 Response regulator receiver domain; Region: Response_reg; pfam00072 41431007304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431007305 active site 41431007306 phosphorylation site [posttranslational modification] 41431007307 intermolecular recognition site; other site 41431007308 dimerization interface [polypeptide binding]; other site 41431007309 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431007310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431007311 active site 41431007312 phosphorylation site [posttranslational modification] 41431007313 intermolecular recognition site; other site 41431007314 dimerization interface [polypeptide binding]; other site 41431007315 calcium/proton exchanger (cax); Region: cax; TIGR00378 41431007316 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 41431007317 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 41431007318 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 41431007319 PhoU domain; Region: PhoU; pfam01895 41431007320 PhoU domain; Region: PhoU; pfam01895 41431007321 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 41431007322 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 41431007323 hypothetical protein; Validated; Region: PRK00153 41431007324 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 41431007325 FAD binding domain; Region: FAD_binding_4; pfam01565 41431007326 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 41431007327 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 41431007328 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 41431007329 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 41431007330 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431007331 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 41431007332 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 41431007333 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 41431007334 GUN4-like; Region: GUN4; pfam05419 41431007335 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 41431007336 putative nucleotide binding site [chemical binding]; other site 41431007337 uridine monophosphate binding site [chemical binding]; other site 41431007338 homohexameric interface [polypeptide binding]; other site 41431007339 ribosome recycling factor; Reviewed; Region: frr; PRK00083 41431007340 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 41431007341 hinge region; other site 41431007342 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 41431007343 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 41431007344 NADP-binding site; other site 41431007345 homotetramer interface [polypeptide binding]; other site 41431007346 substrate binding site [chemical binding]; other site 41431007347 homodimer interface [polypeptide binding]; other site 41431007348 active site 41431007349 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 41431007350 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 41431007351 NADP binding site [chemical binding]; other site 41431007352 active site 41431007353 putative substrate binding site [chemical binding]; other site 41431007354 Protein of unknown function (DUF952); Region: DUF952; pfam06108 41431007355 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 41431007356 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 41431007357 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 41431007358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 41431007359 Cache domain; Region: Cache_1; pfam02743 41431007360 PAS domain S-box; Region: sensory_box; TIGR00229 41431007361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431007362 PAS domain; Region: PAS_9; pfam13426 41431007363 putative active site [active] 41431007364 heme pocket [chemical binding]; other site 41431007365 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 41431007366 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 41431007367 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 41431007368 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 41431007369 hypothetical protein; Validated; Region: PRK00029 41431007370 Uncharacterized conserved protein [Function unknown]; Region: COG0397 41431007371 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 41431007372 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 41431007373 RNA binding surface [nucleotide binding]; other site 41431007374 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 41431007375 ATP-binding site [chemical binding]; other site 41431007376 Gluconate-6-phosphate binding site [chemical binding]; other site 41431007377 Shikimate kinase; Region: SKI; pfam01202 41431007378 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 41431007379 rRNA interaction site [nucleotide binding]; other site 41431007380 S8 interaction site; other site 41431007381 putative laminin-1 binding site; other site 41431007382 elongation factor Ts; Reviewed; Region: tsf; PRK12332 41431007383 UBA/TS-N domain; Region: UBA; pfam00627 41431007384 Elongation factor TS; Region: EF_TS; pfam00889 41431007385 Protein of unknown function (DUF433); Region: DUF433; cl01030 41431007386 pyruvate kinase; Provisional; Region: PRK06354 41431007387 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 41431007388 domain interfaces; other site 41431007389 active site 41431007390 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 41431007391 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 41431007392 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 41431007393 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 41431007394 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 41431007395 HlyD family secretion protein; Region: HlyD_3; pfam13437 41431007396 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 41431007397 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 41431007398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431007399 Walker A/P-loop; other site 41431007400 ATP binding site [chemical binding]; other site 41431007401 Q-loop/lid; other site 41431007402 ABC transporter signature motif; other site 41431007403 Walker B; other site 41431007404 D-loop; other site 41431007405 H-loop/switch region; other site 41431007406 ABC-2 type transporter; Region: ABC2_membrane; cl17235 41431007407 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 41431007408 electron transport complex protein RnfB; Provisional; Region: PRK05113 41431007409 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 41431007410 substrate binding site [chemical binding]; other site 41431007411 NurA domain; Region: NurA; pfam09376 41431007412 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 41431007413 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 41431007414 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431007415 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 41431007416 CAAX protease self-immunity; Region: Abi; pfam02517 41431007417 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 41431007418 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 41431007419 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 41431007420 putative active site [active] 41431007421 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 41431007422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431007423 FeS/SAM binding site; other site 41431007424 HemN C-terminal domain; Region: HemN_C; pfam06969 41431007425 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 41431007426 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 41431007427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 41431007428 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 41431007429 23S rRNA binding site [nucleotide binding]; other site 41431007430 L21 binding site [polypeptide binding]; other site 41431007431 L13 binding site [polypeptide binding]; other site 41431007432 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 41431007433 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 41431007434 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 41431007435 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 41431007436 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 41431007437 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 41431007438 Domain of unknown function DUF21; Region: DUF21; pfam01595 41431007439 FOG: CBS domain [General function prediction only]; Region: COG0517 41431007440 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 41431007441 heat shock protein 90; Provisional; Region: PRK05218 41431007442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431007443 ATP binding site [chemical binding]; other site 41431007444 Mg2+ binding site [ion binding]; other site 41431007445 G-X-G motif; other site 41431007446 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 41431007447 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 41431007448 catalytic motif [active] 41431007449 Catalytic residue [active] 41431007450 Protein of unknown function DUF262; Region: DUF262; pfam03235 41431007451 Uncharacterized conserved protein [Function unknown]; Region: COG1479 41431007452 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007453 putative active site [active] 41431007454 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 41431007455 Response regulator receiver domain; Region: Response_reg; pfam00072 41431007456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431007457 active site 41431007458 phosphorylation site [posttranslational modification] 41431007459 intermolecular recognition site; other site 41431007460 dimerization interface [polypeptide binding]; other site 41431007461 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431007462 DNA binding residues [nucleotide binding] 41431007463 MASE1; Region: MASE1; pfam05231 41431007464 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431007465 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431007466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431007467 dimer interface [polypeptide binding]; other site 41431007468 phosphorylation site [posttranslational modification] 41431007469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431007470 ATP binding site [chemical binding]; other site 41431007471 Mg2+ binding site [ion binding]; other site 41431007472 G-X-G motif; other site 41431007473 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 41431007474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 41431007475 Tup N-terminal; Region: Tup_N; pfam08581 41431007476 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007477 putative active site [active] 41431007478 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 41431007479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431007480 dimer interface [polypeptide binding]; other site 41431007481 phosphorylation site [posttranslational modification] 41431007482 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 41431007483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431007484 Coenzyme A binding pocket [chemical binding]; other site 41431007485 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 41431007486 NlpC/P60 family; Region: NLPC_P60; pfam00877 41431007487 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 41431007488 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 41431007489 putative dimer interface [polypeptide binding]; other site 41431007490 Integral membrane protein DUF92; Region: DUF92; pfam01940 41431007491 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 41431007492 D-xylulose kinase; Region: XylB; TIGR01312 41431007493 nucleotide binding site [chemical binding]; other site 41431007494 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 41431007495 nudix motif; other site 41431007496 ATP-grasp domain; Region: ATP-grasp_4; cl17255 41431007497 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 41431007498 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 41431007499 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 41431007500 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 41431007501 Ycf46; Provisional; Region: ycf46; CHL00195 41431007502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431007503 Walker A motif; other site 41431007504 ATP binding site [chemical binding]; other site 41431007505 Walker B motif; other site 41431007506 arginine finger; other site 41431007507 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 41431007508 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431007509 substrate binding pocket [chemical binding]; other site 41431007510 membrane-bound complex binding site; other site 41431007511 hinge residues; other site 41431007512 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 41431007513 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 41431007514 NAD binding site [chemical binding]; other site 41431007515 dimerization interface [polypeptide binding]; other site 41431007516 product binding site; other site 41431007517 substrate binding site [chemical binding]; other site 41431007518 zinc binding site [ion binding]; other site 41431007519 catalytic residues [active] 41431007520 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 41431007521 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 41431007522 Catalytic site [active] 41431007523 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 41431007524 AIR carboxylase; Region: AIRC; smart01001 41431007525 Protein of function (DUF2518); Region: DUF2518; pfam10726 41431007526 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 41431007527 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431007528 phosphopeptide binding site; other site 41431007529 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431007530 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431007531 metal binding site [ion binding]; metal-binding site 41431007532 active site 41431007533 I-site; other site 41431007534 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431007535 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 41431007536 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431007537 phosphopeptide binding site; other site 41431007538 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431007539 metal binding site [ion binding]; metal-binding site 41431007540 active site 41431007541 I-site; other site 41431007542 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431007543 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 41431007544 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431007545 P-loop; other site 41431007546 Magnesium ion binding site [ion binding]; other site 41431007547 MEKHLA domain; Region: MEKHLA; pfam08670 41431007548 XisH protein; Region: XisH; pfam08814 41431007549 XisI protein; Region: XisI; pfam08869 41431007550 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 41431007551 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 41431007552 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 41431007553 putative active site [active] 41431007554 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 41431007555 Circadian oscillating protein COP23; Region: COP23; pfam14218 41431007556 Uncharacterized conserved protein [Function unknown]; Region: COG2122; cl17892 41431007557 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 41431007558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431007559 ABC-ATPase subunit interface; other site 41431007560 putative PBP binding loops; other site 41431007561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431007562 dimer interface [polypeptide binding]; other site 41431007563 ABC-ATPase subunit interface; other site 41431007564 putative PBP binding loops; other site 41431007565 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 41431007566 Domain of unknown function DUF20; Region: UPF0118; pfam01594 41431007567 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431007568 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 41431007569 substrate binding pocket [chemical binding]; other site 41431007570 membrane-bound complex binding site; other site 41431007571 hinge residues; other site 41431007572 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 41431007573 Protein of unknown function; Region: DUF3971; pfam13116 41431007574 Family of unknown function (DUF490); Region: DUF490; pfam04357 41431007575 TPR repeat; Region: TPR_11; pfam13414 41431007576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431007577 TPR motif; other site 41431007578 binding surface 41431007579 TPR repeat; Region: TPR_11; pfam13414 41431007580 Uncharacterized conserved protein [Function unknown]; Region: COG0432 41431007581 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 41431007582 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 41431007583 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 41431007584 active site 41431007585 AAA domain; Region: AAA_26; pfam13500 41431007586 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 41431007587 Homeodomain-like domain; Region: HTH_23; pfam13384 41431007588 Winged helix-turn helix; Region: HTH_29; pfam13551 41431007589 Winged helix-turn helix; Region: HTH_33; pfam13592 41431007590 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 41431007591 ligand binding site [chemical binding]; other site 41431007592 flexible hinge region; other site 41431007593 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 41431007594 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 41431007595 putative active site [active] 41431007596 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 41431007597 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 41431007598 Walker A/P-loop; other site 41431007599 ATP binding site [chemical binding]; other site 41431007600 Q-loop/lid; other site 41431007601 ABC transporter signature motif; other site 41431007602 Walker B; other site 41431007603 D-loop; other site 41431007604 H-loop/switch region; other site 41431007605 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 41431007606 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 41431007607 HlyD family secretion protein; Region: HlyD_3; pfam13437 41431007608 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 41431007609 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 41431007610 Phosphotransferase enzyme family; Region: APH; pfam01636 41431007611 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 41431007612 nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103 41431007613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431007614 FeS/SAM binding site; other site 41431007615 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 41431007616 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 41431007617 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 41431007618 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 41431007619 ribosomal protein L32; Validated; Region: rpl32; CHL00152 41431007620 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007621 putative active site [active] 41431007622 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 41431007623 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 41431007624 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 41431007625 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 41431007626 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 41431007627 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 41431007628 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431007629 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007630 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007631 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007632 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007633 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 41431007634 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 41431007635 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 41431007636 metal binding site [ion binding]; metal-binding site 41431007637 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431007638 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431007639 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007640 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007641 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007642 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007643 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007644 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431007645 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431007646 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 41431007647 active site 41431007648 metal binding site [ion binding]; metal-binding site 41431007649 TIR domain; Region: TIR_2; pfam13676 41431007650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431007651 Walker A/P-loop; other site 41431007652 ATP binding site [chemical binding]; other site 41431007653 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 41431007654 nucleoside/Zn binding site; other site 41431007655 dimer interface [polypeptide binding]; other site 41431007656 catalytic motif [active] 41431007657 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 41431007658 Predicted ATPase [General function prediction only]; Region: COG4637 41431007659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431007660 Walker A/P-loop; other site 41431007661 ATP binding site [chemical binding]; other site 41431007662 Q-loop/lid; other site 41431007663 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 41431007664 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 41431007665 HIGH motif; other site 41431007666 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 41431007667 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 41431007668 active site 41431007669 KMSKS motif; other site 41431007670 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 41431007671 tRNA binding surface [nucleotide binding]; other site 41431007672 anticodon binding site; other site 41431007673 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 41431007674 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 41431007675 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 41431007676 translation initiation factor IF-2; Region: IF-2; TIGR00487 41431007677 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 41431007678 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 41431007679 G1 box; other site 41431007680 putative GEF interaction site [polypeptide binding]; other site 41431007681 GTP/Mg2+ binding site [chemical binding]; other site 41431007682 Switch I region; other site 41431007683 G2 box; other site 41431007684 G3 box; other site 41431007685 Switch II region; other site 41431007686 G4 box; other site 41431007687 G5 box; other site 41431007688 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 41431007689 Translation-initiation factor 2; Region: IF-2; pfam11987 41431007690 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 41431007691 Protein of unknown function (DUF448); Region: DUF448; pfam04296 41431007692 putative RNA binding cleft [nucleotide binding]; other site 41431007693 transcription elongation factor NusA; Provisional; Region: nusA; PRK12329 41431007694 NusA N-terminal domain; Region: NusA_N; pfam08529 41431007695 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 41431007696 RNA binding site [nucleotide binding]; other site 41431007697 homodimer interface [polypeptide binding]; other site 41431007698 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 41431007699 G-X-X-G motif; other site 41431007700 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 41431007701 G-X-X-G motif; other site 41431007702 ribosome maturation protein RimP; Reviewed; Region: PRK00092 41431007703 Sm and related proteins; Region: Sm_like; cl00259 41431007704 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 41431007705 putative oligomer interface [polypeptide binding]; other site 41431007706 putative RNA binding site [nucleotide binding]; other site 41431007707 ATP synthase I chain; Region: ATP_synt_I; pfam03899 41431007708 ATP synthase CF0 A subunit; Region: atpI; CHL00046 41431007709 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 41431007710 F0F1 ATP synthase subunit C; Validated; Region: PRK07354 41431007711 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 41431007712 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 41431007713 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 41431007714 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 41431007715 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 41431007716 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 41431007717 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 41431007718 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 41431007719 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 41431007720 beta subunit interaction interface [polypeptide binding]; other site 41431007721 Walker A motif; other site 41431007722 ATP binding site [chemical binding]; other site 41431007723 Walker B motif; other site 41431007724 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 41431007725 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 41431007726 core domain interface [polypeptide binding]; other site 41431007727 delta subunit interface [polypeptide binding]; other site 41431007728 epsilon subunit interface [polypeptide binding]; other site 41431007729 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 41431007730 Low molecular weight phosphatase family; Region: LMWPc; cd00115 41431007731 active site 41431007732 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 41431007733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431007734 HAMP domain; Region: HAMP; pfam00672 41431007735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431007736 dimer interface [polypeptide binding]; other site 41431007737 phosphorylation site [posttranslational modification] 41431007738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431007739 ATP binding site [chemical binding]; other site 41431007740 Mg2+ binding site [ion binding]; other site 41431007741 G-X-G motif; other site 41431007742 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 41431007743 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 41431007744 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 41431007745 Walker A/P-loop; other site 41431007746 ATP binding site [chemical binding]; other site 41431007747 Q-loop/lid; other site 41431007748 ABC transporter signature motif; other site 41431007749 Walker B; other site 41431007750 D-loop; other site 41431007751 H-loop/switch region; other site 41431007752 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 41431007753 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 41431007754 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 41431007755 active site 41431007756 Ca binding site [ion binding]; other site 41431007757 catalytic site [active] 41431007758 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 41431007759 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431007760 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 41431007761 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 41431007762 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 41431007763 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 41431007764 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431007765 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431007766 ligand binding site [chemical binding]; other site 41431007767 flexible hinge region; other site 41431007768 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 41431007769 Methyltransferase domain; Region: Methyltransf_31; pfam13847 41431007770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431007771 S-adenosylmethionine binding site [chemical binding]; other site 41431007772 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 41431007773 MutS domain I; Region: MutS_I; pfam01624 41431007774 MutS domain II; Region: MutS_II; pfam05188 41431007775 MutS domain III; Region: MutS_III; pfam05192 41431007776 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 41431007777 Walker A/P-loop; other site 41431007778 ATP binding site [chemical binding]; other site 41431007779 Q-loop/lid; other site 41431007780 ABC transporter signature motif; other site 41431007781 Walker B; other site 41431007782 D-loop; other site 41431007783 H-loop/switch region; other site 41431007784 Integral membrane protein TerC family; Region: TerC; cl10468 41431007785 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 41431007786 glucokinase; Provisional; Region: glk; PRK00292 41431007787 glucokinase, proteobacterial type; Region: glk; TIGR00749 41431007788 DNA adenine methylase (dam); Region: dam; TIGR00571 41431007789 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 41431007790 Amidinotransferase; Region: Amidinotransf; cl12043 41431007791 Uncharacterized conserved protein [Function unknown]; Region: COG1915 41431007792 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 41431007793 homodimer interface [polypeptide binding]; other site 41431007794 Response regulator receiver domain; Region: Response_reg; pfam00072 41431007795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431007796 active site 41431007797 phosphorylation site [posttranslational modification] 41431007798 intermolecular recognition site; other site 41431007799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431007800 dimerization interface [polypeptide binding]; other site 41431007801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431007802 ATP binding site [chemical binding]; other site 41431007803 Mg2+ binding site [ion binding]; other site 41431007804 G-X-G motif; other site 41431007805 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 41431007806 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 41431007807 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 41431007808 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 41431007809 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 41431007810 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 41431007811 Walker A/P-loop; other site 41431007812 ATP binding site [chemical binding]; other site 41431007813 Q-loop/lid; other site 41431007814 ABC transporter signature motif; other site 41431007815 Walker B; other site 41431007816 D-loop; other site 41431007817 H-loop/switch region; other site 41431007818 TOBE-like domain; Region: TOBE_3; pfam12857 41431007819 sulfate transport protein; Provisional; Region: cysT; CHL00187 41431007820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431007821 dimer interface [polypeptide binding]; other site 41431007822 conserved gate region; other site 41431007823 putative PBP binding loops; other site 41431007824 ABC-ATPase subunit interface; other site 41431007825 sulfate transport protein; Provisional; Region: cysT; CHL00187 41431007826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431007827 dimer interface [polypeptide binding]; other site 41431007828 conserved gate region; other site 41431007829 putative PBP binding loops; other site 41431007830 ABC-ATPase subunit interface; other site 41431007831 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 41431007832 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 41431007833 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 41431007834 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431007835 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 41431007836 ligand binding site [chemical binding]; other site 41431007837 flexible hinge region; other site 41431007838 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 41431007839 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 41431007840 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 41431007841 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431007842 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431007843 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 41431007844 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431007845 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 41431007846 hypothetical protein; Provisional; Region: PRK07377 41431007847 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 41431007848 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 41431007849 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 41431007850 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 41431007851 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 41431007852 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 41431007853 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 41431007854 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 41431007855 putative active site [active] 41431007856 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 41431007857 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 41431007858 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 41431007859 Substrate binding site; other site 41431007860 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 41431007861 ABC1 family; Region: ABC1; cl17513 41431007862 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 41431007863 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 41431007864 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 41431007865 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 41431007866 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 41431007867 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431007868 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 41431007869 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 41431007870 Walker A motif; other site 41431007871 ATP binding site [chemical binding]; other site 41431007872 Walker B motif; other site 41431007873 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 41431007874 tetramer interface [polypeptide binding]; other site 41431007875 dimer interface [polypeptide binding]; other site 41431007876 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 41431007877 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431007878 catalytic loop [active] 41431007879 iron binding site [ion binding]; other site 41431007880 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431007881 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 41431007882 putative ADP-binding pocket [chemical binding]; other site 41431007883 Bacterial sugar transferase; Region: Bac_transf; pfam02397 41431007884 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 41431007885 PHP domain; Region: PHP; pfam02811 41431007886 active site 41431007887 Phycobilisome protein; Region: Phycobilisome; cl08227 41431007888 allophycocyanin beta subunit; Region: apcB; CHL00088 41431007889 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 41431007890 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 41431007891 catalytic core [active] 41431007892 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 41431007893 catalytic core [active] 41431007894 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431007895 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431007896 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 41431007897 cofactor binding site; other site 41431007898 DNA binding site [nucleotide binding] 41431007899 substrate interaction site [chemical binding]; other site 41431007900 TrkA-N domain; Region: TrkA_N; pfam02254 41431007901 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 41431007902 TrkA-N domain; Region: TrkA_N; pfam02254 41431007903 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 41431007904 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 41431007905 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 41431007906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431007907 Walker A motif; other site 41431007908 ATP binding site [chemical binding]; other site 41431007909 Walker B motif; other site 41431007910 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 41431007911 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 41431007912 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 41431007913 AAA domain; Region: AAA_21; pfam13304 41431007914 Transposase; Region: HTH_Tnp_IS630; pfam01710 41431007915 DDE superfamily endonuclease; Region: DDE_3; pfam13358 41431007916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 41431007917 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 41431007918 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 41431007919 homodimer interface [polypeptide binding]; other site 41431007920 substrate-cofactor binding pocket; other site 41431007921 catalytic residue [active] 41431007922 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 41431007923 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 41431007924 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 41431007925 protein binding site [polypeptide binding]; other site 41431007926 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431007927 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431007928 ligand binding site [chemical binding]; other site 41431007929 flexible hinge region; other site 41431007930 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 41431007931 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 41431007932 putative di-iron ligands [ion binding]; other site 41431007933 ATP-grasp domain; Region: ATP-grasp_4; cl17255 41431007934 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 41431007935 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431007936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 41431007937 Predicted kinase [General function prediction only]; Region: COG0645 41431007938 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 41431007939 ATP-binding site [chemical binding]; other site 41431007940 Gluconate-6-phosphate binding site [chemical binding]; other site 41431007941 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007942 putative active site [active] 41431007943 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 41431007944 Family description; Region: UvrD_C_2; pfam13538 41431007945 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 41431007946 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 41431007947 transmembrane helices; other site 41431007948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 41431007949 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 41431007950 Peptidase family M50; Region: Peptidase_M50; pfam02163 41431007951 active site 41431007952 putative substrate binding region [chemical binding]; other site 41431007953 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431007954 putative active site [active] 41431007955 chaperone protein DnaJ; Provisional; Region: PRK14299 41431007956 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431007957 HSP70 interaction site [polypeptide binding]; other site 41431007958 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 41431007959 substrate binding site [polypeptide binding]; other site 41431007960 dimer interface [polypeptide binding]; other site 41431007961 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 41431007962 P-loop; other site 41431007963 Magnesium ion binding site [ion binding]; other site 41431007964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 41431007965 non-specific DNA binding site [nucleotide binding]; other site 41431007966 salt bridge; other site 41431007967 sequence-specific DNA binding site [nucleotide binding]; other site 41431007968 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 41431007969 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 41431007970 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 41431007971 dimerization interface [polypeptide binding]; other site 41431007972 active site 41431007973 metal binding site [ion binding]; metal-binding site 41431007974 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 41431007975 dsRNA binding site [nucleotide binding]; other site 41431007976 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 41431007977 Methyltransferase domain; Region: Methyltransf_31; pfam13847 41431007978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431007979 S-adenosylmethionine binding site [chemical binding]; other site 41431007980 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 41431007981 putative ADP-binding pocket [chemical binding]; other site 41431007982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431007983 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 41431007984 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 41431007985 membrane protein; Provisional; Region: PRK14419 41431007986 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 41431007987 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 41431007988 Uncharacterized conserved protein [Function unknown]; Region: COG4279 41431007989 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431007990 active site 41431007991 NTP binding site [chemical binding]; other site 41431007992 metal binding triad [ion binding]; metal-binding site 41431007993 antibiotic binding site [chemical binding]; other site 41431007994 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 41431007995 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 41431007996 putative tRNA-binding site [nucleotide binding]; other site 41431007997 B3/4 domain; Region: B3_4; pfam03483 41431007998 tRNA synthetase B5 domain; Region: B5; smart00874 41431007999 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 41431008000 dimer interface [polypeptide binding]; other site 41431008001 motif 1; other site 41431008002 motif 3; other site 41431008003 motif 2; other site 41431008004 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 41431008005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 41431008006 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431008007 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008008 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008009 thiamine monophosphate kinase; Provisional; Region: PRK05731 41431008010 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 41431008011 ATP binding site [chemical binding]; other site 41431008012 dimerization interface [polypeptide binding]; other site 41431008013 Domain of unknown function (DUF389); Region: DUF389; pfam04087 41431008014 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 41431008015 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 41431008016 Active site cavity [active] 41431008017 catalytic acid [active] 41431008018 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 41431008019 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 41431008020 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 41431008021 HlyD family secretion protein; Region: HlyD_3; pfam13437 41431008022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 41431008023 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 41431008024 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 41431008025 RNA binding surface [nucleotide binding]; other site 41431008026 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 41431008027 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431008028 FeS/SAM binding site; other site 41431008029 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 41431008030 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431008031 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431008032 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431008033 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431008034 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 41431008035 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 41431008036 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 41431008037 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 41431008038 RNA binding site [nucleotide binding]; other site 41431008039 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 41431008040 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 41431008041 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 41431008042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431008043 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431008044 Probable transposase; Region: OrfB_IS605; pfam01385 41431008045 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 41431008046 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 41431008047 ring oligomerisation interface [polypeptide binding]; other site 41431008048 ATP/Mg binding site [chemical binding]; other site 41431008049 stacking interactions; other site 41431008050 hinge regions; other site 41431008051 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 41431008052 oligomerisation interface [polypeptide binding]; other site 41431008053 mobile loop; other site 41431008054 roof hairpin; other site 41431008055 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 41431008056 Predicted ATPase [General function prediction only]; Region: COG4637 41431008057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431008058 Walker A/P-loop; other site 41431008059 ATP binding site [chemical binding]; other site 41431008060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431008061 ABC transporter signature motif; other site 41431008062 Walker B; other site 41431008063 D-loop; other site 41431008064 H-loop/switch region; other site 41431008065 intracellular protease, PfpI family; Region: PfpI; TIGR01382 41431008066 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 41431008067 conserved cys residue [active] 41431008068 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 41431008069 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431008070 catalytic loop [active] 41431008071 iron binding site [ion binding]; other site 41431008072 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 41431008073 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431008074 HSP70 interaction site [polypeptide binding]; other site 41431008075 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 41431008076 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 41431008077 inhibitor-cofactor binding pocket; inhibition site 41431008078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431008079 catalytic residue [active] 41431008080 Bacitracin resistance protein BacA; Region: BacA; pfam02673 41431008081 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 41431008082 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431008083 anthranilate synthase component I-like protein; Validated; Region: PRK05940 41431008084 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 41431008085 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 41431008086 Cobalt transport protein; Region: CbiQ; pfam02361 41431008087 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 41431008088 PLD-like domain; Region: PLDc_2; pfam13091 41431008089 putative active site [active] 41431008090 catalytic site [active] 41431008091 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 41431008092 PLD-like domain; Region: PLDc_2; pfam13091 41431008093 putative active site [active] 41431008094 catalytic site [active] 41431008095 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 41431008096 Helix-hairpin-helix motif; Region: HHH; pfam00633 41431008097 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 41431008098 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 41431008099 dimerization interface [polypeptide binding]; other site 41431008100 domain crossover interface; other site 41431008101 redox-dependent activation switch; other site 41431008102 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 41431008103 RNase_H superfamily; Region: RNase_H_2; pfam13482 41431008104 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 41431008105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431008106 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431008107 Probable transposase; Region: OrfB_IS605; pfam01385 41431008108 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 41431008109 30S subunit binding site; other site 41431008110 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 41431008111 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 41431008112 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 41431008113 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 41431008114 protein binding site [polypeptide binding]; other site 41431008115 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 41431008116 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 41431008117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 41431008118 active site 41431008119 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431008120 putative active site [active] 41431008121 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 41431008122 DDE superfamily endonuclease; Region: DDE_4; pfam13359 41431008123 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 41431008124 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 41431008125 alpha subunit interface [polypeptide binding]; other site 41431008126 TPP binding site [chemical binding]; other site 41431008127 heterodimer interface [polypeptide binding]; other site 41431008128 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 41431008129 protein-export membrane protein SecD; Region: secD; TIGR01129 41431008130 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 41431008131 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 41431008132 Protein export membrane protein; Region: SecD_SecF; pfam02355 41431008133 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 41431008134 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 41431008135 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 41431008136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431008137 motif II; other site 41431008138 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 41431008139 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431008140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431008141 active site 41431008142 phosphorylation site [posttranslational modification] 41431008143 intermolecular recognition site; other site 41431008144 dimerization interface [polypeptide binding]; other site 41431008145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 41431008146 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 41431008147 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 41431008148 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 41431008149 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 41431008150 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 41431008151 Malic enzyme, N-terminal domain; Region: malic; pfam00390 41431008152 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 41431008153 putative NAD(P) binding site [chemical binding]; other site 41431008154 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 41431008155 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 41431008156 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 41431008157 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 41431008158 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 41431008159 ligand binding site [chemical binding]; other site 41431008160 homodimer interface [polypeptide binding]; other site 41431008161 NAD(P) binding site [chemical binding]; other site 41431008162 trimer interface B [polypeptide binding]; other site 41431008163 trimer interface A [polypeptide binding]; other site 41431008164 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 41431008165 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 41431008166 active site 41431008167 catalytic tetrad [active] 41431008168 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 41431008169 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 41431008170 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 41431008171 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 41431008172 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 41431008173 active site 41431008174 HIGH motif; other site 41431008175 dimer interface [polypeptide binding]; other site 41431008176 KMSKS motif; other site 41431008177 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 41431008178 RNA binding surface [nucleotide binding]; other site 41431008179 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 41431008180 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 41431008181 Walker A/P-loop; other site 41431008182 ATP binding site [chemical binding]; other site 41431008183 Q-loop/lid; other site 41431008184 ABC transporter signature motif; other site 41431008185 Walker B; other site 41431008186 D-loop; other site 41431008187 H-loop/switch region; other site 41431008188 YacP-like NYN domain; Region: NYN_YacP; pfam05991 41431008189 hypothetical protein; Validated; Region: PRK07411 41431008190 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 41431008191 ATP binding site [chemical binding]; other site 41431008192 substrate interface [chemical binding]; other site 41431008193 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 41431008194 active site residue [active] 41431008195 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 41431008196 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 41431008197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431008198 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 41431008199 HicB family; Region: HicB; pfam05534 41431008200 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 41431008201 MPN+ (JAMM) motif; other site 41431008202 Zinc-binding site [ion binding]; other site 41431008203 Uncharacterized conserved protein [Function unknown]; Region: COG3937 41431008204 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 41431008205 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 41431008206 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 41431008207 Inward rectifier potassium channel; Region: IRK; pfam01007 41431008208 Chorismate mutase type II; Region: CM_2; cl00693 41431008209 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 41431008210 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 41431008211 active site 41431008212 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 41431008213 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 41431008214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431008215 Walker A motif; other site 41431008216 ATP binding site [chemical binding]; other site 41431008217 Walker B motif; other site 41431008218 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 41431008219 Tic22-like family; Region: Tic22; pfam04278 41431008220 Tic22-like family; Region: Tic22; cl04468 41431008221 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 41431008222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431008223 S-adenosylmethionine binding site [chemical binding]; other site 41431008224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 41431008225 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 41431008226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 41431008227 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 41431008228 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 41431008229 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 41431008230 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 41431008231 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 41431008232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431008233 Walker A motif; other site 41431008234 ATP binding site [chemical binding]; other site 41431008235 Walker B motif; other site 41431008236 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 41431008237 Clp protease; Region: CLP_protease; pfam00574 41431008238 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 41431008239 oligomer interface [polypeptide binding]; other site 41431008240 active site residues [active] 41431008241 trigger factor; Provisional; Region: tig; PRK01490 41431008242 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 41431008243 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 41431008244 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 41431008245 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 41431008246 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 41431008247 dihydrodipicolinate synthase; Region: dapA; TIGR00674 41431008248 dimer interface [polypeptide binding]; other site 41431008249 active site 41431008250 catalytic residue [active] 41431008251 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 41431008252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 41431008253 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 41431008254 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431008255 putative active site [active] 41431008256 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 41431008257 putative active site [active] 41431008258 substrate binding site [chemical binding]; other site 41431008259 redox center [active] 41431008260 DnaJ domain; Region: DnaJ; pfam00226 41431008261 HSP70 interaction site [polypeptide binding]; other site 41431008262 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 41431008263 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431008264 Methyltransferase domain; Region: Methyltransf_23; pfam13489 41431008265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431008266 S-adenosylmethionine binding site [chemical binding]; other site 41431008267 Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795 41431008268 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431008269 active site 41431008270 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431008271 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431008272 Methyltransferase domain; Region: Methyltransf_24; pfam13578 41431008273 Family description; Region: VCBS; pfam13517 41431008274 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 41431008275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431008276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431008277 homodimer interface [polypeptide binding]; other site 41431008278 catalytic residue [active] 41431008279 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 41431008280 IHF - DNA interface [nucleotide binding]; other site 41431008281 IHF dimer interface [polypeptide binding]; other site 41431008282 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 41431008283 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 41431008284 TrkA-N domain; Region: TrkA_N; pfam02254 41431008285 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431008286 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008287 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008288 lipoyl synthase; Provisional; Region: PRK05481 41431008289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431008290 FeS/SAM binding site; other site 41431008291 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431008292 YcfA-like protein; Region: YcfA; pfam07927 41431008293 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431008294 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 41431008295 Cysteine-rich domain; Region: CCG; pfam02754 41431008296 Cysteine-rich domain; Region: CCG; pfam02754 41431008297 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431008298 putative active site [active] 41431008299 Acylphosphatase; Region: Acylphosphatase; cl00551 41431008300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008301 binding surface 41431008302 TPR motif; other site 41431008303 TPR repeat; Region: TPR_11; pfam13414 41431008304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008305 binding surface 41431008306 TPR repeat; Region: TPR_11; pfam13414 41431008307 TPR motif; other site 41431008308 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 41431008309 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 41431008310 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 41431008311 hinge; other site 41431008312 active site 41431008313 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 41431008314 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 41431008315 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 41431008316 AAA domain; Region: AAA_22; pfam13401 41431008317 Protein of unknown function DUF262; Region: DUF262; pfam03235 41431008318 Uncharacterized conserved protein [Function unknown]; Region: COG4938 41431008319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431008320 Walker A/P-loop; other site 41431008321 ATP binding site [chemical binding]; other site 41431008322 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 41431008323 AAA domain; Region: AAA_22; pfam13401 41431008324 Protein of unknown function DUF45; Region: DUF45; pfam01863 41431008325 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 41431008326 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 41431008327 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 41431008328 putative active site [active] 41431008329 putative NTP binding site [chemical binding]; other site 41431008330 putative nucleic acid binding site [nucleotide binding]; other site 41431008331 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 41431008332 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 41431008333 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431008334 active site 41431008335 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 41431008336 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 41431008337 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 41431008338 putative active site [active] 41431008339 putative NTP binding site [chemical binding]; other site 41431008340 putative nucleic acid binding site [nucleotide binding]; other site 41431008341 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 41431008342 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 41431008343 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431008344 active site 41431008345 Protein of unknown function DUF86; Region: DUF86; cl01031 41431008346 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431008347 active site 41431008348 NTP binding site [chemical binding]; other site 41431008349 metal binding triad [ion binding]; metal-binding site 41431008350 antibiotic binding site [chemical binding]; other site 41431008351 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 41431008352 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 41431008353 putative addiction module antidote; Region: doc_partner; TIGR02609 41431008354 Uncharacterized conserved protein [Function unknown]; Region: COG2361 41431008355 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431008356 active site 41431008357 NTP binding site [chemical binding]; other site 41431008358 metal binding triad [ion binding]; metal-binding site 41431008359 antibiotic binding site [chemical binding]; other site 41431008360 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 41431008361 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 41431008362 Transposase; Region: HTH_Tnp_1; cl17663 41431008363 Transposase; Region: DDE_Tnp_ISL3; pfam01610 41431008364 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431008365 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 41431008366 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 41431008367 Helix-turn-helix domain; Region: HTH_28; pfam13518 41431008368 Winged helix-turn helix; Region: HTH_29; pfam13551 41431008369 Homeodomain-like domain; Region: HTH_32; pfam13565 41431008370 Integrase core domain; Region: rve; pfam00665 41431008371 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 41431008372 AAA domain; Region: AAA_22; pfam13401 41431008373 Bacterial TniB protein; Region: TniB; pfam05621 41431008374 TniQ; Region: TniQ; pfam06527 41431008375 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 41431008376 DDE superfamily endonuclease; Region: DDE_4; pfam13359 41431008377 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 41431008378 Methyltransferase domain; Region: Methyltransf_26; pfam13659 41431008379 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 41431008380 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431008381 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431008382 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 41431008383 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 41431008384 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431008385 ATP binding site [chemical binding]; other site 41431008386 putative Mg++ binding site [ion binding]; other site 41431008387 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 41431008388 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 41431008389 Integrase core domain; Region: rve; pfam00665 41431008390 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 41431008391 AAA domain; Region: AAA_22; pfam13401 41431008392 TniQ; Region: TniQ; pfam06527 41431008393 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 41431008394 AAA domain; Region: AAA_14; pfam13173 41431008395 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431008396 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 41431008397 substrate binding site [chemical binding]; other site 41431008398 active site 41431008399 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 41431008400 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 41431008401 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 41431008402 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 41431008403 DctM-like transporters; Region: DctM; pfam06808 41431008404 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 41431008405 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 41431008406 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 41431008407 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 41431008408 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 41431008409 Soluble P-type ATPase [General function prediction only]; Region: COG4087 41431008410 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 41431008411 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 41431008412 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 41431008413 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 41431008414 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 41431008415 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 41431008416 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 41431008417 active site 41431008418 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 41431008419 metal binding site [ion binding]; metal-binding site 41431008420 ornithine carbamoyltransferase; Provisional; Region: PRK00779 41431008421 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 41431008422 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 41431008423 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 41431008424 Protein of unknown function (DUF433); Region: DUF433; pfam04255 41431008425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431008426 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431008427 Probable transposase; Region: OrfB_IS605; pfam01385 41431008428 Uncharacterized conserved protein [Function unknown]; Region: COG3791 41431008429 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 41431008430 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 41431008431 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 41431008432 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 41431008433 H+ Antiporter protein; Region: 2A0121; TIGR00900 41431008434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431008435 putative substrate translocation pore; other site 41431008436 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 41431008437 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 41431008438 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 41431008439 active site 41431008440 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 41431008441 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 41431008442 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 41431008443 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 41431008444 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 41431008445 active site 41431008446 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 41431008447 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 41431008448 putative NADP binding site [chemical binding]; other site 41431008449 KR domain; Region: KR; pfam08659 41431008450 active site 41431008451 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 41431008452 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 41431008453 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 41431008454 active site 41431008455 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 41431008456 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 41431008457 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 41431008458 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 41431008459 Condensation domain; Region: Condensation; pfam00668 41431008460 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431008461 Nonribosomal peptide synthase; Region: NRPS; pfam08415 41431008462 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 41431008463 acyl-activating enzyme (AAE) consensus motif; other site 41431008464 AMP binding site [chemical binding]; other site 41431008465 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431008466 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 41431008467 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 41431008468 active site 41431008469 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 41431008470 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 41431008471 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431008472 Condensation domain; Region: Condensation; pfam00668 41431008473 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431008474 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 41431008475 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 41431008476 acyl-activating enzyme (AAE) consensus motif; other site 41431008477 AMP binding site [chemical binding]; other site 41431008478 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431008479 Condensation domain; Region: Condensation; pfam00668 41431008480 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431008481 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 41431008482 Condensation domain; Region: Condensation; pfam00668 41431008483 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431008484 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 41431008485 acyl-activating enzyme (AAE) consensus motif; other site 41431008486 AMP binding site [chemical binding]; other site 41431008487 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431008488 Condensation domain; Region: Condensation; pfam00668 41431008489 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431008490 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 41431008491 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 41431008492 acyl-activating enzyme (AAE) consensus motif; other site 41431008493 AMP binding site [chemical binding]; other site 41431008494 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431008495 Condensation domain; Region: Condensation; pfam00668 41431008496 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431008497 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 41431008498 Condensation domain; Region: Condensation; pfam00668 41431008499 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431008500 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 41431008501 Condensation domain; Region: Condensation; pfam00668 41431008502 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431008503 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 41431008504 acyl-activating enzyme (AAE) consensus motif; other site 41431008505 AMP binding site [chemical binding]; other site 41431008506 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431008507 Condensation domain; Region: Condensation; pfam00668 41431008508 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431008509 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 41431008510 Condensation domain; Region: Condensation; pfam00668 41431008511 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431008512 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 41431008513 acyl-activating enzyme (AAE) consensus motif; other site 41431008514 AMP binding site [chemical binding]; other site 41431008515 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431008516 Condensation domain; Region: Condensation; pfam00668 41431008517 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431008518 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 41431008519 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 41431008520 Condensation domain; Region: Condensation; pfam00668 41431008521 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431008522 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 41431008523 acyl-activating enzyme (AAE) consensus motif; other site 41431008524 AMP binding site [chemical binding]; other site 41431008525 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431008526 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 41431008527 NAD(P) binding pocket [chemical binding]; other site 41431008528 NAD synthetase; Provisional; Region: PRK13981 41431008529 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 41431008530 multimer interface [polypeptide binding]; other site 41431008531 active site 41431008532 catalytic triad [active] 41431008533 protein interface 1 [polypeptide binding]; other site 41431008534 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 41431008535 homodimer interface [polypeptide binding]; other site 41431008536 NAD binding pocket [chemical binding]; other site 41431008537 ATP binding pocket [chemical binding]; other site 41431008538 Mg binding site [ion binding]; other site 41431008539 active-site loop [active] 41431008540 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 41431008541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 41431008542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 41431008543 MORN repeat; Region: MORN; cl14787 41431008544 MORN repeat; Region: MORN; cl14787 41431008545 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 41431008546 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 41431008547 ABC-ATPase subunit interface; other site 41431008548 dimer interface [polypeptide binding]; other site 41431008549 putative PBP binding regions; other site 41431008550 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 41431008551 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 41431008552 ABC-ATPase subunit interface; other site 41431008553 dimer interface [polypeptide binding]; other site 41431008554 putative PBP binding regions; other site 41431008555 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 41431008556 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 41431008557 Walker A/P-loop; other site 41431008558 ATP binding site [chemical binding]; other site 41431008559 Q-loop/lid; other site 41431008560 ABC transporter signature motif; other site 41431008561 Walker B; other site 41431008562 D-loop; other site 41431008563 H-loop/switch region; other site 41431008564 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 41431008565 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 41431008566 siderophore binding site; other site 41431008567 AMIN domain; Region: AMIN; pfam11741 41431008568 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 41431008569 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 41431008570 N-terminal plug; other site 41431008571 ligand-binding site [chemical binding]; other site 41431008572 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 41431008573 Uncharacterized conserved protein [Function unknown]; Region: COG1656 41431008574 Protein of unknown function DUF82; Region: DUF82; pfam01927 41431008575 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 41431008576 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 41431008577 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 41431008578 SnoaL-like domain; Region: SnoaL_3; pfam13474 41431008579 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 41431008580 GIY-YIG motif/motif A; other site 41431008581 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431008582 short chain dehydrogenase; Provisional; Region: PRK08303 41431008583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008584 NAD(P) binding site [chemical binding]; other site 41431008585 active site 41431008586 glyoxylate reductase; Reviewed; Region: PRK13243 41431008587 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 41431008588 dimerization interface [polypeptide binding]; other site 41431008589 ligand binding site [chemical binding]; other site 41431008590 NADP binding site [chemical binding]; other site 41431008591 catalytic site [active] 41431008592 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431008593 GAF domain; Region: GAF; cl17456 41431008594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431008595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431008596 phosphorylation site [posttranslational modification] 41431008597 dimer interface [polypeptide binding]; other site 41431008598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431008599 ATP binding site [chemical binding]; other site 41431008600 Mg2+ binding site [ion binding]; other site 41431008601 G-X-G motif; other site 41431008602 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 41431008603 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 41431008604 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 41431008605 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905 41431008606 putative active site [active] 41431008607 Zn binding site [ion binding]; other site 41431008608 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 41431008609 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 41431008610 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 41431008611 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 41431008612 minor groove reading motif; other site 41431008613 helix-hairpin-helix signature motif; other site 41431008614 substrate binding pocket [chemical binding]; other site 41431008615 active site 41431008616 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 41431008617 active site 41431008618 8-oxo-dGMP binding site [chemical binding]; other site 41431008619 nudix motif; other site 41431008620 metal binding site [ion binding]; metal-binding site 41431008621 Protein of unknown function (DUF760); Region: DUF760; pfam05542 41431008622 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 41431008623 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 41431008624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431008625 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431008626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431008627 DNA binding residues [nucleotide binding] 41431008628 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 41431008629 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 41431008630 putative acyl-acceptor binding pocket; other site 41431008631 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 41431008632 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 41431008633 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 41431008634 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 41431008635 Bacterial SH3 domain; Region: SH3_3; cl17532 41431008636 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 41431008637 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 41431008638 active site 41431008639 metal binding site [ion binding]; metal-binding site 41431008640 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 41431008641 photosystem II 47 kDa protein; Region: psbB; CHL00062 41431008642 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 41431008643 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 41431008644 ATP cone domain; Region: ATP-cone; pfam03477 41431008645 30S ribosomal protein S1; Reviewed; Region: PRK07400 41431008646 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 41431008647 RNA binding site [nucleotide binding]; other site 41431008648 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 41431008649 RNA binding site [nucleotide binding]; other site 41431008650 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 41431008651 RNA binding site [nucleotide binding]; other site 41431008652 HEAT repeats; Region: HEAT_2; pfam13646 41431008653 HEAT repeats; Region: HEAT_2; pfam13646 41431008654 Phycobilisome protein; Region: Phycobilisome; cl08227 41431008655 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 41431008656 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431008657 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 41431008658 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 41431008659 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 41431008660 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 41431008661 HEAT repeats; Region: HEAT_2; pfam13646 41431008662 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 41431008663 protein binding surface [polypeptide binding]; other site 41431008664 FO synthase subunit 2; Reviewed; Region: PRK07360 41431008665 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 41431008666 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 41431008667 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 41431008668 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 41431008669 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 41431008670 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 41431008671 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 41431008672 active site 41431008673 catalytic site [active] 41431008674 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 41431008675 Protein of unknown function (DUF497); Region: DUF497; pfam04365 41431008676 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 41431008677 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 41431008678 GTP-binding protein YchF; Reviewed; Region: PRK09601 41431008679 YchF GTPase; Region: YchF; cd01900 41431008680 G1 box; other site 41431008681 GTP/Mg2+ binding site [chemical binding]; other site 41431008682 Switch I region; other site 41431008683 G2 box; other site 41431008684 Switch II region; other site 41431008685 G3 box; other site 41431008686 G4 box; other site 41431008687 G5 box; other site 41431008688 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 41431008689 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 41431008690 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 41431008691 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 41431008692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431008693 Coenzyme A binding pocket [chemical binding]; other site 41431008694 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 41431008695 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 41431008696 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 41431008697 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431008698 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 41431008699 active site 41431008700 metal binding site [ion binding]; metal-binding site 41431008701 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 41431008702 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 41431008703 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 41431008704 trimer interface [polypeptide binding]; other site 41431008705 putative metal binding site [ion binding]; other site 41431008706 Photosystem II protein Y (PsbY); Region: PsbY; pfam06298 41431008707 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 41431008708 active site 41431008709 SAM binding site [chemical binding]; other site 41431008710 homodimer interface [polypeptide binding]; other site 41431008711 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 41431008712 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 41431008713 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 41431008714 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 41431008715 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 41431008716 Lipoxygenase; Region: Lipoxygenase; pfam00305 41431008717 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 41431008718 Cytochrome P450; Region: p450; cl12078 41431008719 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 41431008720 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 41431008721 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 41431008722 DNA polymerase I; Provisional; Region: PRK05755 41431008723 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 41431008724 active site 41431008725 metal binding site 1 [ion binding]; metal-binding site 41431008726 putative 5' ssDNA interaction site; other site 41431008727 metal binding site 3; metal-binding site 41431008728 metal binding site 2 [ion binding]; metal-binding site 41431008729 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 41431008730 putative DNA binding site [nucleotide binding]; other site 41431008731 putative metal binding site [ion binding]; other site 41431008732 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 41431008733 active site 41431008734 catalytic site [active] 41431008735 substrate binding site [chemical binding]; other site 41431008736 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 41431008737 active site 41431008738 DNA binding site [nucleotide binding] 41431008739 catalytic site [active] 41431008740 exonuclease SbcC; Region: sbcc; TIGR00618 41431008741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431008742 Walker A/P-loop; other site 41431008743 ATP binding site [chemical binding]; other site 41431008744 Q-loop/lid; other site 41431008745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431008746 ABC transporter signature motif; other site 41431008747 Walker B; other site 41431008748 D-loop; other site 41431008749 H-loop/switch region; other site 41431008750 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 41431008751 nucleotide binding site/active site [active] 41431008752 HIT family signature motif; other site 41431008753 catalytic residue [active] 41431008754 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 41431008755 ABC1 family; Region: ABC1; cl17513 41431008756 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 41431008757 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 41431008758 Walker A/P-loop; other site 41431008759 ATP binding site [chemical binding]; other site 41431008760 Q-loop/lid; other site 41431008761 ABC transporter signature motif; other site 41431008762 Walker B; other site 41431008763 D-loop; other site 41431008764 H-loop/switch region; other site 41431008765 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 41431008766 Zn2+ binding site [ion binding]; other site 41431008767 Mg2+ binding site [ion binding]; other site 41431008768 Oligomerisation domain; Region: Oligomerisation; pfam02410 41431008769 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 41431008770 L-asparaginase II; Region: Asparaginase_II; cl01842 41431008771 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 41431008772 pantothenate kinase; Reviewed; Region: PRK13331 41431008773 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 41431008774 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 41431008775 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 41431008776 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 41431008777 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 41431008778 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 41431008779 DRTGG domain; Region: DRTGG; pfam07085 41431008780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 41431008781 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431008782 dimerization interface [polypeptide binding]; other site 41431008783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431008784 dimer interface [polypeptide binding]; other site 41431008785 phosphorylation site [posttranslational modification] 41431008786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431008787 ATP binding site [chemical binding]; other site 41431008788 Mg2+ binding site [ion binding]; other site 41431008789 G-X-G motif; other site 41431008790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431008791 Major Facilitator Superfamily; Region: MFS_1; pfam07690 41431008792 putative substrate translocation pore; other site 41431008793 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431008794 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008795 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431008796 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008797 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008798 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008799 GUN4-like; Region: GUN4; pfam05419 41431008800 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 41431008801 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 41431008802 active site 41431008803 catalytic tetrad [active] 41431008804 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431008805 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008806 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008807 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431008808 Ferritin-like; Region: Ferritin-like; pfam12902 41431008809 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 41431008810 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 41431008811 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 41431008812 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 41431008813 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 41431008814 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 41431008815 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 41431008816 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 41431008817 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 41431008818 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 41431008819 potential catalytic triad [active] 41431008820 conserved cys residue [active] 41431008821 Major royal jelly protein; Region: MRJP; pfam03022 41431008822 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 41431008823 Domain interface; other site 41431008824 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 41431008825 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 41431008826 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 41431008827 Helix-turn-helix domain; Region: HTH_36; pfam13730 41431008828 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 41431008829 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 41431008830 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 41431008831 putative active site [active] 41431008832 catalytic site [active] 41431008833 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 41431008834 putative ligand binding site [chemical binding]; other site 41431008835 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 41431008836 putative rRNA binding site [nucleotide binding]; other site 41431008837 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 41431008838 oxyanion hole [active] 41431008839 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 41431008840 Low molecular weight phosphatase family; Region: LMWPc; cd00115 41431008841 active site 41431008842 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431008843 putative active site [active] 41431008844 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 41431008845 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 41431008846 HlyD family secretion protein; Region: HlyD_3; pfam13437 41431008847 GUN4-like; Region: GUN4; pfam05419 41431008848 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 41431008849 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 41431008850 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 41431008851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008852 TPR motif; other site 41431008853 TPR repeat; Region: TPR_11; pfam13414 41431008854 binding surface 41431008855 TPR repeat; Region: TPR_11; pfam13414 41431008856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008857 TPR motif; other site 41431008858 binding surface 41431008859 Tetratricopeptide repeat; Region: TPR_16; pfam13432 41431008860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008861 binding surface 41431008862 TPR motif; other site 41431008863 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 41431008864 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431008865 H-loop/switch region; other site 41431008866 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 41431008867 TPR repeat; Region: TPR_11; pfam13414 41431008868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008869 binding surface 41431008870 TPR motif; other site 41431008871 TPR repeat; Region: TPR_11; pfam13414 41431008872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431008873 binding surface 41431008874 Tetratricopeptide repeat; Region: TPR_16; pfam13432 41431008875 TPR motif; other site 41431008876 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 41431008877 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 41431008878 active site 41431008879 zinc binding site [ion binding]; other site 41431008880 short chain dehydrogenase; Provisional; Region: PRK09134 41431008881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431008882 NAD(P) binding site [chemical binding]; other site 41431008883 active site 41431008884 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 41431008885 catalytic center binding site [active] 41431008886 ATP binding site [chemical binding]; other site 41431008887 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 41431008888 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 41431008889 DXD motif; other site 41431008890 PilZ domain; Region: PilZ; pfam07238 41431008891 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 41431008892 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 41431008893 putative dimer interface [polypeptide binding]; other site 41431008894 putative anticodon binding site; other site 41431008895 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 41431008896 homodimer interface [polypeptide binding]; other site 41431008897 motif 1; other site 41431008898 motif 2; other site 41431008899 active site 41431008900 motif 3; other site 41431008901 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 41431008902 homotrimer interaction site [polypeptide binding]; other site 41431008903 zinc binding site [ion binding]; other site 41431008904 CDP-binding sites; other site 41431008905 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 41431008906 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 41431008907 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 41431008908 Walker A/P-loop; other site 41431008909 ATP binding site [chemical binding]; other site 41431008910 Q-loop/lid; other site 41431008911 ABC transporter signature motif; other site 41431008912 Walker B; other site 41431008913 D-loop; other site 41431008914 H-loop/switch region; other site 41431008915 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 41431008916 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 41431008917 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 41431008918 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 41431008919 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 41431008920 putative active site [active] 41431008921 putative dimer interface [polypeptide binding]; other site 41431008922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431008923 S-adenosylmethionine binding site [chemical binding]; other site 41431008924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431008925 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431008926 Probable transposase; Region: OrfB_IS605; pfam01385 41431008927 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431008928 Transposase IS200 like; Region: Y1_Tnp; pfam01797 41431008929 seryl-tRNA synthetase; Provisional; Region: PRK05431 41431008930 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 41431008931 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 41431008932 dimer interface [polypeptide binding]; other site 41431008933 active site 41431008934 motif 1; other site 41431008935 motif 2; other site 41431008936 motif 3; other site 41431008937 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 41431008938 GTPase RsgA; Reviewed; Region: PRK12289 41431008939 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 41431008940 RNA binding site [nucleotide binding]; other site 41431008941 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 41431008942 GTPase/Zn-binding domain interface [polypeptide binding]; other site 41431008943 GTP/Mg2+ binding site [chemical binding]; other site 41431008944 G4 box; other site 41431008945 G5 box; other site 41431008946 G1 box; other site 41431008947 Switch I region; other site 41431008948 G2 box; other site 41431008949 G3 box; other site 41431008950 Switch II region; other site 41431008951 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 41431008952 CPxP motif; other site 41431008953 chaperone protein DnaJ; Provisional; Region: PRK14293 41431008954 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431008955 HSP70 interaction site [polypeptide binding]; other site 41431008956 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 41431008957 Zn binding sites [ion binding]; other site 41431008958 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 41431008959 dimer interface [polypeptide binding]; other site 41431008960 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 41431008961 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 41431008962 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 41431008963 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 41431008964 Photosystem II Pbs27; Region: PSII_Pbs27; cl11841 41431008965 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 41431008966 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431008967 Walker A/P-loop; other site 41431008968 ATP binding site [chemical binding]; other site 41431008969 fumarate hydratase; Reviewed; Region: fumC; PRK00485 41431008970 Class II fumarases; Region: Fumarase_classII; cd01362 41431008971 active site 41431008972 tetramer interface [polypeptide binding]; other site 41431008973 PemK-like protein; Region: PemK; pfam02452 41431008974 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431008975 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 41431008976 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 41431008977 putative ligand binding site [chemical binding]; other site 41431008978 photosystem I reaction center subunit X; Reviewed; Region: PRK13214 41431008979 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 41431008980 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 41431008981 dimer interface [polypeptide binding]; other site 41431008982 ssDNA binding site [nucleotide binding]; other site 41431008983 tetramer (dimer of dimers) interface [polypeptide binding]; other site 41431008984 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 41431008985 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 41431008986 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 41431008987 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 41431008988 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 41431008989 metal-binding site [ion binding] 41431008990 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 41431008991 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 41431008992 protein I interface; other site 41431008993 D2 interface; other site 41431008994 protein T interface; other site 41431008995 chlorophyll binding site; other site 41431008996 beta carotene binding site; other site 41431008997 pheophytin binding site; other site 41431008998 manganese-stabilizing polypeptide interface; other site 41431008999 CP43 interface; other site 41431009000 protein L interface; other site 41431009001 oxygen evolving complex binding site; other site 41431009002 bromide binding site; other site 41431009003 quinone binding site; other site 41431009004 Fe binding site [ion binding]; other site 41431009005 core light harvesting interface; other site 41431009006 cytochrome b559 alpha subunit interface; other site 41431009007 cytochrome c-550 interface; other site 41431009008 protein J interface; other site 41431009009 V-type ATP synthase subunit A; Provisional; Region: PRK04192 41431009010 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 41431009011 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 41431009012 Walker A motif/ATP binding site; other site 41431009013 Walker B motif; other site 41431009014 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 41431009015 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 41431009016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431009017 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431009018 Probable transposase; Region: OrfB_IS605; pfam01385 41431009019 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431009020 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 41431009021 V-type ATP synthase subunit E; Provisional; Region: PRK01558 41431009022 V-type ATP synthase subunit E; Provisional; Region: PRK01005 41431009023 V-type ATP synthase subunit K; Provisional; Region: PRK09621 41431009024 ATP synthase subunit C; Region: ATP-synt_C; cl00466 41431009025 V-type ATP synthase subunit I; Validated; Region: PRK05771 41431009026 V-type ATP synthase subunit D; Provisional; Region: PRK02195 41431009027 V-type ATP synthase subunit B; Provisional; Region: PRK02118 41431009028 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 41431009029 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 41431009030 Walker A motif homologous position; other site 41431009031 Walker B motif; other site 41431009032 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431009033 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 41431009034 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 41431009035 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 41431009036 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 41431009037 TrkA-N domain; Region: TrkA_N; pfam02254 41431009038 NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180 41431009039 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 41431009040 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 41431009041 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 41431009042 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431009043 T5orf172 domain; Region: T5orf172; pfam10544 41431009044 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 41431009045 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 41431009046 HIGH motif; other site 41431009047 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 41431009048 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 41431009049 active site 41431009050 KMSKS motif; other site 41431009051 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 41431009052 tRNA binding surface [nucleotide binding]; other site 41431009053 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431009054 YcfA-like protein; Region: YcfA; pfam07927 41431009055 Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476 41431009056 Protein of unknown function (DUF433); Region: DUF433; pfam04255 41431009057 acyl carrier protein; Provisional; Region: acpP; PRK00982 41431009058 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 41431009059 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 41431009060 dimer interface [polypeptide binding]; other site 41431009061 active site 41431009062 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 41431009063 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431009064 HSP70 interaction site [polypeptide binding]; other site 41431009065 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 41431009066 Probable galactinol--sucrose galactosyltransferase; Region: PLN02711 41431009067 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 41431009068 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 41431009069 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431009070 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431009071 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431009072 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 41431009073 active site 41431009074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431009075 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431009076 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431009077 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 41431009078 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 41431009079 phosphoenolpyruvate synthase; Validated; Region: PRK06464 41431009080 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 41431009081 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 41431009082 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 41431009083 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009084 putative active site [active] 41431009085 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 41431009086 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 41431009087 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 41431009088 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 41431009089 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 41431009090 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431009091 GAF domain; Region: GAF; pfam01590 41431009092 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431009093 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431009094 metal binding site [ion binding]; metal-binding site 41431009095 active site 41431009096 I-site; other site 41431009097 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431009098 ligand binding site [chemical binding]; other site 41431009099 flexible hinge region; other site 41431009100 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 41431009101 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 41431009102 putative active site [active] 41431009103 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 41431009104 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 41431009105 Walker A/P-loop; other site 41431009106 ATP binding site [chemical binding]; other site 41431009107 Q-loop/lid; other site 41431009108 ABC transporter signature motif; other site 41431009109 Walker B; other site 41431009110 D-loop; other site 41431009111 H-loop/switch region; other site 41431009112 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 41431009113 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 41431009114 E3 interaction surface; other site 41431009115 lipoyl attachment site [posttranslational modification]; other site 41431009116 HlyD family secretion protein; Region: HlyD_3; pfam13437 41431009117 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431009118 TPR repeat; Region: TPR_11; pfam13414 41431009119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431009120 binding surface 41431009121 TPR motif; other site 41431009122 TPR repeat; Region: TPR_11; pfam13414 41431009123 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 41431009124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431009125 TPR motif; other site 41431009126 binding surface 41431009127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431009128 binding surface 41431009129 TPR motif; other site 41431009130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431009131 binding surface 41431009132 TPR motif; other site 41431009133 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431009134 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 41431009135 active site 41431009136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431009137 Tetratricopeptide repeat; Region: TPR_16; pfam13432 41431009138 binding surface 41431009139 TPR motif; other site 41431009140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431009141 binding surface 41431009142 TPR motif; other site 41431009143 TPR repeat; Region: TPR_11; pfam13414 41431009144 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 41431009145 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 41431009146 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 41431009147 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 41431009148 OstA-like protein; Region: OstA; cl00844 41431009149 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 41431009150 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 41431009151 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 41431009152 proposed catalytic triad [active] 41431009153 active site nucleophile [active] 41431009154 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 41431009155 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 41431009156 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431009157 active site 41431009158 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 41431009159 active site 41431009160 Nuclease-related domain; Region: NERD; pfam08378 41431009161 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 41431009162 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 41431009163 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431009164 FeS/SAM binding site; other site 41431009165 TRAM domain; Region: TRAM; pfam01938 41431009166 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 41431009167 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431009168 active site 41431009169 ATP binding site [chemical binding]; other site 41431009170 substrate binding site [chemical binding]; other site 41431009171 activation loop (A-loop); other site 41431009172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431009173 TPR motif; other site 41431009174 TPR repeat; Region: TPR_11; pfam13414 41431009175 binding surface 41431009176 phosphoglucomutase; Region: PLN02307 41431009177 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 41431009178 substrate binding site [chemical binding]; other site 41431009179 dimer interface [polypeptide binding]; other site 41431009180 active site 41431009181 metal binding site [ion binding]; metal-binding site 41431009182 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 41431009183 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 41431009184 Walker A/P-loop; other site 41431009185 ATP binding site [chemical binding]; other site 41431009186 Q-loop/lid; other site 41431009187 ABC transporter signature motif; other site 41431009188 Walker B; other site 41431009189 D-loop; other site 41431009190 H-loop/switch region; other site 41431009191 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 41431009192 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 41431009193 Walker A/P-loop; other site 41431009194 ATP binding site [chemical binding]; other site 41431009195 Q-loop/lid; other site 41431009196 ABC transporter signature motif; other site 41431009197 Walker B; other site 41431009198 D-loop; other site 41431009199 H-loop/switch region; other site 41431009200 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 41431009201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431009202 dimer interface [polypeptide binding]; other site 41431009203 conserved gate region; other site 41431009204 putative PBP binding loops; other site 41431009205 ABC-ATPase subunit interface; other site 41431009206 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 41431009207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431009208 dimer interface [polypeptide binding]; other site 41431009209 conserved gate region; other site 41431009210 putative PBP binding loops; other site 41431009211 ABC-ATPase subunit interface; other site 41431009212 PBP superfamily domain; Region: PBP_like_2; cl17296 41431009213 PBP superfamily domain; Region: PBP_like_2; cl17296 41431009214 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 41431009215 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 41431009216 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 41431009217 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431009218 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431009219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431009220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431009221 dimer interface [polypeptide binding]; other site 41431009222 phosphorylation site [posttranslational modification] 41431009223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431009224 ATP binding site [chemical binding]; other site 41431009225 Mg2+ binding site [ion binding]; other site 41431009226 G-X-G motif; other site 41431009227 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431009228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009229 active site 41431009230 phosphorylation site [posttranslational modification] 41431009231 intermolecular recognition site; other site 41431009232 dimerization interface [polypeptide binding]; other site 41431009233 ribonuclease III; Reviewed; Region: rnc; PRK00102 41431009234 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 41431009235 dimerization interface [polypeptide binding]; other site 41431009236 active site 41431009237 metal binding site [ion binding]; metal-binding site 41431009238 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 41431009239 dsRNA binding site [nucleotide binding]; other site 41431009240 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 41431009241 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 41431009242 active site 41431009243 substrate binding site [chemical binding]; other site 41431009244 Mg2+ binding site [ion binding]; other site 41431009245 EamA-like transporter family; Region: EamA; cl17759 41431009246 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 41431009247 substrate binding site [chemical binding]; other site 41431009248 SOUL heme-binding protein; Region: SOUL; pfam04832 41431009249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431009250 TPR motif; other site 41431009251 binding surface 41431009252 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 41431009253 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 41431009254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 41431009255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431009256 Coenzyme A binding pocket [chemical binding]; other site 41431009257 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 41431009258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 41431009259 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 41431009260 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 41431009261 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431009262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009263 active site 41431009264 phosphorylation site [posttranslational modification] 41431009265 intermolecular recognition site; other site 41431009266 dimerization interface [polypeptide binding]; other site 41431009267 ParB-like nuclease domain; Region: ParBc; cl02129 41431009268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 41431009269 non-specific DNA binding site [nucleotide binding]; other site 41431009270 salt bridge; other site 41431009271 sequence-specific DNA binding site [nucleotide binding]; other site 41431009272 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 41431009273 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 41431009274 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 41431009275 dimerization interface [polypeptide binding]; other site 41431009276 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 41431009277 ATP binding site [chemical binding]; other site 41431009278 DDE superfamily endonuclease; Region: DDE_5; cl17874 41431009279 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009280 putative active site [active] 41431009281 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 41431009282 active site pocket [active] 41431009283 putative dimer interface [polypeptide binding]; other site 41431009284 putative cataytic base [active] 41431009285 S-layer homology domain; Region: SLH; pfam00395 41431009286 S-layer homology domain; Region: SLH; pfam00395 41431009287 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 41431009288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431009289 NAD(P) binding site [chemical binding]; other site 41431009290 active site 41431009291 FAD binding domain; Region: FAD_binding_4; pfam01565 41431009292 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 41431009293 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 41431009294 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431009295 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 41431009296 Ligand binding site; other site 41431009297 Putative Catalytic site; other site 41431009298 DXD motif; other site 41431009299 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431009300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431009301 NAD(P) binding site [chemical binding]; other site 41431009302 active site 41431009303 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 41431009304 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 41431009305 Methyltransferase domain; Region: Methyltransf_23; pfam13489 41431009306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431009307 S-adenosylmethionine binding site [chemical binding]; other site 41431009308 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 41431009309 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 41431009310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431009311 NAD(P) binding site [chemical binding]; other site 41431009312 active site 41431009313 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 41431009314 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 41431009315 substrate binding site; other site 41431009316 Response regulator receiver domain; Region: Response_reg; pfam00072 41431009317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009318 active site 41431009319 phosphorylation site [posttranslational modification] 41431009320 intermolecular recognition site; other site 41431009321 dimerization interface [polypeptide binding]; other site 41431009322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009323 Response regulator receiver domain; Region: Response_reg; pfam00072 41431009324 active site 41431009325 phosphorylation site [posttranslational modification] 41431009326 intermolecular recognition site; other site 41431009327 dimerization interface [polypeptide binding]; other site 41431009328 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431009329 Cache domain; Region: Cache_1; pfam02743 41431009330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431009331 dimerization interface [polypeptide binding]; other site 41431009332 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431009333 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431009334 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431009335 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431009336 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 41431009337 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431009338 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 41431009339 dimer interface [polypeptide binding]; other site 41431009340 putative CheW interface [polypeptide binding]; other site 41431009341 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 41431009342 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431009343 dimerization interface [polypeptide binding]; other site 41431009344 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431009345 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431009346 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431009347 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431009348 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 41431009349 dimerization interface [polypeptide binding]; other site 41431009350 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431009351 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 41431009352 dimer interface [polypeptide binding]; other site 41431009353 putative CheW interface [polypeptide binding]; other site 41431009354 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431009355 putative binding surface; other site 41431009356 active site 41431009357 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 41431009358 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 41431009359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431009360 ATP binding site [chemical binding]; other site 41431009361 Mg2+ binding site [ion binding]; other site 41431009362 G-X-G motif; other site 41431009363 Two component signalling adaptor domain; Region: CheW; smart00260 41431009364 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431009365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009366 active site 41431009367 phosphorylation site [posttranslational modification] 41431009368 intermolecular recognition site; other site 41431009369 dimerization interface [polypeptide binding]; other site 41431009370 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 41431009371 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 41431009372 ribosomal protein L21; Region: rpl21; CHL00075 41431009373 cell division topological specificity factor MinE; Provisional; Region: PRK13988 41431009374 septum site-determining protein MinD; Region: minD_bact; TIGR01968 41431009375 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 41431009376 Switch I; other site 41431009377 Switch II; other site 41431009378 septum formation inhibitor; Reviewed; Region: minC; PRK00513 41431009379 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 41431009380 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431009381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009382 active site 41431009383 phosphorylation site [posttranslational modification] 41431009384 intermolecular recognition site; other site 41431009385 dimerization interface [polypeptide binding]; other site 41431009386 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431009387 DNA binding site [nucleotide binding] 41431009388 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 41431009389 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 41431009390 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 41431009391 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 41431009392 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 41431009393 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 41431009394 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 41431009395 Walker A/P-loop; other site 41431009396 ATP binding site [chemical binding]; other site 41431009397 Q-loop/lid; other site 41431009398 ABC transporter signature motif; other site 41431009399 Walker B; other site 41431009400 D-loop; other site 41431009401 H-loop/switch region; other site 41431009402 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 41431009403 putative carbohydrate binding site [chemical binding]; other site 41431009404 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 41431009405 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431009406 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431009407 active site 41431009408 NTP binding site [chemical binding]; other site 41431009409 metal binding triad [ion binding]; metal-binding site 41431009410 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431009411 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 41431009412 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431009413 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431009414 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 41431009415 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 41431009416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431009417 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 41431009418 Coenzyme A binding pocket [chemical binding]; other site 41431009419 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431009420 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009421 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009422 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 41431009423 Bacterial sugar transferase; Region: Bac_transf; pfam02397 41431009424 Domain of unknown function DUF20; Region: UPF0118; pfam01594 41431009425 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 41431009426 ADP-glucose phosphorylase; Region: PLN02643 41431009427 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 41431009428 nucleotide binding site/active site [active] 41431009429 HIT family signature motif; other site 41431009430 catalytic residue [active] 41431009431 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009432 putative active site [active] 41431009433 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 41431009434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 41431009435 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431009436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009437 active site 41431009438 phosphorylation site [posttranslational modification] 41431009439 intermolecular recognition site; other site 41431009440 dimerization interface [polypeptide binding]; other site 41431009441 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431009442 DNA binding site [nucleotide binding] 41431009443 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 41431009444 putative GSH binding site [chemical binding]; other site 41431009445 catalytic residues [active] 41431009446 BolA-like protein; Region: BolA; pfam01722 41431009447 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009448 putative active site [active] 41431009449 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 41431009450 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431009451 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 41431009452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 41431009453 putative glycosyl transferase; Provisional; Region: PRK10307 41431009454 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 41431009455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431009456 TPR motif; other site 41431009457 TPR repeat; Region: TPR_11; pfam13414 41431009458 binding surface 41431009459 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 41431009460 homodimer interface [polypeptide binding]; other site 41431009461 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 41431009462 active site pocket [active] 41431009463 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 41431009464 Rhomboid family; Region: Rhomboid; pfam01694 41431009465 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009466 putative active site [active] 41431009467 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 41431009468 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 41431009469 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 41431009470 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431009471 DDE superfamily endonuclease; Region: DDE_4; pfam13359 41431009472 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 41431009473 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 41431009474 UGMP family protein; Validated; Region: PRK09604 41431009475 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 41431009476 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 41431009477 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 41431009478 Transcriptional regulator [Transcription]; Region: LysR; COG0583 41431009479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 41431009480 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 41431009481 putative dimerization interface [polypeptide binding]; other site 41431009482 CHAT domain; Region: CHAT; cl17868 41431009483 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 41431009484 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431009485 phosphopeptide binding site; other site 41431009486 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 41431009487 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 41431009488 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 41431009489 Walker A/P-loop; other site 41431009490 ATP binding site [chemical binding]; other site 41431009491 Q-loop/lid; other site 41431009492 ABC transporter signature motif; other site 41431009493 Walker B; other site 41431009494 D-loop; other site 41431009495 H-loop/switch region; other site 41431009496 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 41431009497 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 41431009498 dimer interface [polypeptide binding]; other site 41431009499 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 41431009500 active site 41431009501 Fe binding site [ion binding]; other site 41431009502 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 41431009503 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 41431009504 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 41431009505 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431009506 putative active site [active] 41431009507 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 41431009508 Chain length determinant protein; Region: Wzz; cl15801 41431009509 AAA domain; Region: AAA_31; pfam13614 41431009510 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 41431009511 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 41431009512 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 41431009513 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 41431009514 nucleotide binding pocket [chemical binding]; other site 41431009515 K-X-D-G motif; other site 41431009516 catalytic site [active] 41431009517 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 41431009518 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 41431009519 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 41431009520 Dimer interface [polypeptide binding]; other site 41431009521 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431009522 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009523 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431009524 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009525 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009527 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009528 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009529 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431009530 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 41431009531 substrate binding site [chemical binding]; other site 41431009532 peptide chain release factor 2; Validated; Region: prfB; PRK00578 41431009533 This domain is found in peptide chain release factors; Region: PCRF; smart00937 41431009534 RF-1 domain; Region: RF-1; pfam00472 41431009535 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 41431009536 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 41431009537 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 41431009538 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 41431009539 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 41431009540 dimer interface [polypeptide binding]; other site 41431009541 motif 1; other site 41431009542 active site 41431009543 motif 2; other site 41431009544 motif 3; other site 41431009545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431009546 Coenzyme A binding pocket [chemical binding]; other site 41431009547 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 41431009548 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 41431009549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 41431009550 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 41431009551 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 41431009552 putative hydrophobic ligand binding site [chemical binding]; other site 41431009553 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 41431009554 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 41431009555 thiamine phosphate binding site [chemical binding]; other site 41431009556 active site 41431009557 pyrophosphate binding site [ion binding]; other site 41431009558 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 41431009559 thiS-thiF/thiG interaction site; other site 41431009560 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 41431009561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431009562 S-adenosylmethionine binding site [chemical binding]; other site 41431009563 Double zinc ribbon; Region: DZR; pfam12773 41431009564 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 41431009565 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 41431009566 Cl- selectivity filter; other site 41431009567 Cl- binding residues [ion binding]; other site 41431009568 pore gating glutamate residue; other site 41431009569 dimer interface [polypeptide binding]; other site 41431009570 H+/Cl- coupling transport residue; other site 41431009571 FOG: CBS domain [General function prediction only]; Region: COG0517 41431009572 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 41431009573 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 41431009574 Ligand Binding Site [chemical binding]; other site 41431009575 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431009576 Ligand Binding Site [chemical binding]; other site 41431009577 Predicted membrane protein (DUF2335); Region: DUF2335; cl02210 41431009578 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 41431009579 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 41431009580 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 41431009581 dimerization interface [polypeptide binding]; other site 41431009582 active site 41431009583 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 41431009584 haemagglutination activity domain; Region: Haemagg_act; pfam05860 41431009585 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 41431009586 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 41431009587 Surface antigen; Region: Bac_surface_Ag; pfam01103 41431009588 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431009589 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431009590 Cache domain; Region: Cache_1; pfam02743 41431009591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431009592 dimerization interface [polypeptide binding]; other site 41431009593 PAS domain S-box; Region: sensory_box; TIGR00229 41431009594 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431009595 putative active site [active] 41431009596 heme pocket [chemical binding]; other site 41431009597 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 41431009598 glutaminase A; Region: Gln_ase; TIGR03814 41431009599 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 41431009600 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 41431009601 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 41431009602 FOG: CBS domain [General function prediction only]; Region: COG0517 41431009603 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 41431009604 NeuB family; Region: NeuB; pfam03102 41431009605 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 41431009606 NeuB binding interface [polypeptide binding]; other site 41431009607 putative substrate binding site [chemical binding]; other site 41431009608 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 41431009609 Metal-binding active site; metal-binding site 41431009610 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 41431009611 AP (apurinic/apyrimidinic) site pocket; other site 41431009612 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 41431009613 TrkA-N domain; Region: TrkA_N; pfam02254 41431009614 TrkA-C domain; Region: TrkA_C; pfam02080 41431009615 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 41431009616 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431009617 cofactor binding site; other site 41431009618 DNA binding site [nucleotide binding] 41431009619 substrate interaction site [chemical binding]; other site 41431009620 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 41431009621 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431009622 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 41431009623 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 41431009624 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 41431009625 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431009626 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 41431009627 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 41431009628 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 41431009629 PAS domain S-box; Region: sensory_box; TIGR00229 41431009630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431009631 putative active site [active] 41431009632 heme pocket [chemical binding]; other site 41431009633 PAS domain S-box; Region: sensory_box; TIGR00229 41431009634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431009635 putative active site [active] 41431009636 heme pocket [chemical binding]; other site 41431009637 PAS fold; Region: PAS_4; pfam08448 41431009638 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431009639 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431009640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431009641 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 41431009642 putative active site [active] 41431009643 heme pocket [chemical binding]; other site 41431009644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431009645 dimer interface [polypeptide binding]; other site 41431009646 phosphorylation site [posttranslational modification] 41431009647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431009648 ATP binding site [chemical binding]; other site 41431009649 Mg2+ binding site [ion binding]; other site 41431009650 G-X-G motif; other site 41431009651 Response regulator receiver domain; Region: Response_reg; pfam00072 41431009652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009653 active site 41431009654 phosphorylation site [posttranslational modification] 41431009655 intermolecular recognition site; other site 41431009656 dimerization interface [polypeptide binding]; other site 41431009657 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 41431009658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431009659 dimer interface [polypeptide binding]; other site 41431009660 phosphorylation site [posttranslational modification] 41431009661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431009662 ATP binding site [chemical binding]; other site 41431009663 Mg2+ binding site [ion binding]; other site 41431009664 G-X-G motif; other site 41431009665 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431009666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009667 active site 41431009668 phosphorylation site [posttranslational modification] 41431009669 intermolecular recognition site; other site 41431009670 dimerization interface [polypeptide binding]; other site 41431009671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431009672 DNA binding site [nucleotide binding] 41431009673 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 41431009674 Homeodomain-like domain; Region: HTH_23; cl17451 41431009675 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 41431009676 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431009677 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431009678 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 41431009679 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 41431009680 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 41431009681 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 41431009682 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 41431009683 active site 41431009684 metal binding site [ion binding]; metal-binding site 41431009685 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431009686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 41431009687 TPR motif; other site 41431009688 binding surface 41431009689 Tetratricopeptide repeat; Region: TPR_12; pfam13424 41431009690 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 41431009691 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 41431009692 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 41431009693 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 41431009694 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431009695 active site 41431009696 ATP binding site [chemical binding]; other site 41431009697 substrate binding site [chemical binding]; other site 41431009698 activation loop (A-loop); other site 41431009699 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 41431009700 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 41431009701 putative ligand binding site [chemical binding]; other site 41431009702 Methyltransferase domain; Region: Methyltransf_23; pfam13489 41431009703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431009704 S-adenosylmethionine binding site [chemical binding]; other site 41431009705 phosphate acetyltransferase; Reviewed; Region: PRK05632 41431009706 DRTGG domain; Region: DRTGG; pfam07085 41431009707 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 41431009708 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 41431009709 2TM domain; Region: 2TM; pfam13239 41431009710 Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303 41431009711 inhibitor binding site; inhibition site 41431009712 catalytic motif [active] 41431009713 Catalytic residue [active] 41431009714 Active site flap [active] 41431009715 Protein of unknown function DUF262; Region: DUF262; pfam03235 41431009716 Uncharacterized conserved protein [Function unknown]; Region: COG1479 41431009717 Protein of unknown function DUF262; Region: DUF262; pfam03235 41431009718 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 41431009719 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 41431009720 trimer interface [polypeptide binding]; other site 41431009721 dimer interface [polypeptide binding]; other site 41431009722 putative active site [active] 41431009723 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 41431009724 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 41431009725 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 41431009726 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 41431009727 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 41431009728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 41431009729 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 41431009730 homodimer interface [polypeptide binding]; other site 41431009731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431009732 catalytic residue [active] 41431009733 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 41431009734 active site 41431009735 ribulose/triose binding site [chemical binding]; other site 41431009736 phosphate binding site [ion binding]; other site 41431009737 substrate (anthranilate) binding pocket [chemical binding]; other site 41431009738 product (indole) binding pocket [chemical binding]; other site 41431009739 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 41431009740 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 41431009741 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 41431009742 catalytic triad [active] 41431009743 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 41431009744 Predicted transcriptional regulator [Transcription]; Region: COG3682 41431009745 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 41431009746 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 41431009747 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 41431009748 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 41431009749 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 41431009750 Fatty acid desaturase; Region: FA_desaturase; pfam00487 41431009751 putative di-iron ligands [ion binding]; other site 41431009752 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 41431009753 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 41431009754 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 41431009755 dimerization interface [polypeptide binding]; other site 41431009756 putative ATP binding site [chemical binding]; other site 41431009757 Haemagglutinin; Region: Hemagglutinin; pfam00509 41431009758 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 41431009759 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 41431009760 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 41431009761 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 41431009762 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 41431009763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431009764 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 41431009765 Walker A motif; other site 41431009766 ATP binding site [chemical binding]; other site 41431009767 Walker B motif; other site 41431009768 arginine finger; other site 41431009769 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 41431009770 metal ion-dependent adhesion site (MIDAS); other site 41431009771 Protein of unknown function DUF262; Region: DUF262; pfam03235 41431009772 Uncharacterized conserved protein [Function unknown]; Region: COG1479 41431009773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 41431009774 Transposase; Region: HTH_Tnp_1; cl17663 41431009775 Transposase; Region: DDE_Tnp_ISL3; pfam01610 41431009776 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 41431009777 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 41431009778 acetyl-CoA synthetase; Provisional; Region: PRK00174 41431009779 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 41431009780 active site 41431009781 CoA binding site [chemical binding]; other site 41431009782 acyl-activating enzyme (AAE) consensus motif; other site 41431009783 AMP binding site [chemical binding]; other site 41431009784 acetate binding site [chemical binding]; other site 41431009785 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 41431009786 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 41431009787 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 41431009788 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 41431009789 Walker A/P-loop; other site 41431009790 ATP binding site [chemical binding]; other site 41431009791 Q-loop/lid; other site 41431009792 ABC transporter signature motif; other site 41431009793 Walker B; other site 41431009794 D-loop; other site 41431009795 H-loop/switch region; other site 41431009796 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 41431009797 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 41431009798 Walker A/P-loop; other site 41431009799 ATP binding site [chemical binding]; other site 41431009800 Q-loop/lid; other site 41431009801 ABC transporter signature motif; other site 41431009802 Walker B; other site 41431009803 D-loop; other site 41431009804 H-loop/switch region; other site 41431009805 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 41431009806 NMT1-like family; Region: NMT1_2; pfam13379 41431009807 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 41431009808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 41431009809 NMT1-like family; Region: NMT1_2; pfam13379 41431009810 NMT1/THI5 like; Region: NMT1; pfam09084 41431009811 Response regulator receiver domain; Region: Response_reg; pfam00072 41431009812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009813 active site 41431009814 phosphorylation site [posttranslational modification] 41431009815 intermolecular recognition site; other site 41431009816 dimerization interface [polypeptide binding]; other site 41431009817 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431009818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431009819 active site 41431009820 phosphorylation site [posttranslational modification] 41431009821 intermolecular recognition site; other site 41431009822 dimerization interface [polypeptide binding]; other site 41431009823 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431009824 DNA binding site [nucleotide binding] 41431009825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431009826 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431009827 dimerization interface [polypeptide binding]; other site 41431009828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431009829 dimer interface [polypeptide binding]; other site 41431009830 phosphorylation site [posttranslational modification] 41431009831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431009832 ATP binding site [chemical binding]; other site 41431009833 Mg2+ binding site [ion binding]; other site 41431009834 G-X-G motif; other site 41431009835 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 41431009836 intersubunit interface [polypeptide binding]; other site 41431009837 active site 41431009838 catalytic residue [active] 41431009839 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 41431009840 Recombination protein O N terminal; Region: RecO_N; pfam11967 41431009841 Recombination protein O C terminal; Region: RecO_C; pfam02565 41431009842 H+ Antiporter protein; Region: 2A0121; TIGR00900 41431009843 Putative restriction endonuclease; Region: Uma2; pfam05685 41431009844 putative active site [active] 41431009845 adenylosuccinate lyase; Provisional; Region: PRK07380 41431009846 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 41431009847 tetramer interface [polypeptide binding]; other site 41431009848 active site 41431009849 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 41431009850 Clp protease; Region: CLP_protease; pfam00574 41431009851 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 41431009852 oligomer interface [polypeptide binding]; other site 41431009853 active site residues [active] 41431009854 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 41431009855 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431009856 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 41431009857 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 41431009858 interchain domain interface [polypeptide binding]; other site 41431009859 intrachain domain interface; other site 41431009860 Qi binding site; other site 41431009861 Qo binding site; other site 41431009862 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 41431009863 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 41431009864 Qi binding site; other site 41431009865 intrachain domain interface; other site 41431009866 interchain domain interface [polypeptide binding]; other site 41431009867 heme bH binding site [chemical binding]; other site 41431009868 heme bL binding site [chemical binding]; other site 41431009869 Qo binding site; other site 41431009870 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 41431009871 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 41431009872 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 41431009873 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 41431009874 Cupin domain; Region: Cupin_2; pfam07883 41431009875 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 41431009876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431009877 Methyltransferase domain; Region: Methyltransf_31; pfam13847 41431009878 S-adenosylmethionine binding site [chemical binding]; other site 41431009879 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 41431009880 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 41431009881 putative active site [active] 41431009882 Zn binding site [ion binding]; other site 41431009883 Late competence development protein ComFB; Region: ComFB; pfam10719 41431009884 prolyl-tRNA synthetase; Provisional; Region: PRK09194 41431009885 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 41431009886 dimer interface [polypeptide binding]; other site 41431009887 motif 1; other site 41431009888 active site 41431009889 motif 2; other site 41431009890 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 41431009891 putative deacylase active site [active] 41431009892 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 41431009893 active site 41431009894 motif 3; other site 41431009895 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 41431009896 anticodon binding site; other site 41431009897 Uncharacterized conserved protein [Function unknown]; Region: COG5464 41431009898 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 41431009899 glycine dehydrogenase; Provisional; Region: PRK05367 41431009900 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 41431009901 tetramer interface [polypeptide binding]; other site 41431009902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431009903 catalytic residue [active] 41431009904 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 41431009905 tetramer interface [polypeptide binding]; other site 41431009906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431009907 catalytic residue [active] 41431009908 acyl carrier protein; Provisional; Region: acpP; PRK00982 41431009909 acyl carrier protein; Provisional; Region: acpP; PRK00982 41431009910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 41431009911 non-specific DNA binding site [nucleotide binding]; other site 41431009912 salt bridge; other site 41431009913 sequence-specific DNA binding site [nucleotide binding]; other site 41431009914 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 41431009915 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 41431009916 Pirin-related protein [General function prediction only]; Region: COG1741 41431009917 Pirin; Region: Pirin; pfam02678 41431009918 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 41431009919 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431009920 active site 41431009921 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 41431009922 putative ADP-binding pocket [chemical binding]; other site 41431009923 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431009924 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431009925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 41431009926 active site 41431009927 lipoyl synthase; Provisional; Region: PRK12928 41431009928 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431009929 FeS/SAM binding site; other site 41431009930 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 41431009931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431009932 Walker A motif; other site 41431009933 ATP binding site [chemical binding]; other site 41431009934 Walker B motif; other site 41431009935 arginine finger; other site 41431009936 Peptidase family M41; Region: Peptidase_M41; pfam01434 41431009937 S-layer homology domain; Region: SLH; pfam00395 41431009938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 41431009939 active site 41431009940 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 41431009941 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 41431009942 photosystem II reaction center protein Psb28; Region: PS_II_psb28; TIGR03047 41431009943 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 41431009944 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 41431009945 putative NAD(P) binding site [chemical binding]; other site 41431009946 putative active site [active] 41431009947 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 41431009948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 41431009949 Walker A motif; other site 41431009950 ATP binding site [chemical binding]; other site 41431009951 Walker B motif; other site 41431009952 arginine finger; other site 41431009953 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 41431009954 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 41431009955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431009956 Coenzyme A binding pocket [chemical binding]; other site 41431009957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 41431009958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431009959 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431009960 Probable transposase; Region: OrfB_IS605; pfam01385 41431009961 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 41431009962 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 41431009963 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 41431009964 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 41431009965 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 41431009966 dimer interface [polypeptide binding]; other site 41431009967 putative functional site; other site 41431009968 putative MPT binding site; other site 41431009969 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 41431009970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 41431009971 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 41431009972 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 41431009973 substrate binding site [chemical binding]; other site 41431009974 catalytic Zn binding site [ion binding]; other site 41431009975 NAD binding site [chemical binding]; other site 41431009976 structural Zn binding site [ion binding]; other site 41431009977 dimer interface [polypeptide binding]; other site 41431009978 Acylphosphatase; Region: Acylphosphatase; pfam00708 41431009979 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 41431009980 HypF finger; Region: zf-HYPF; pfam07503 41431009981 HypF finger; Region: zf-HYPF; pfam07503 41431009982 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 41431009983 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 41431009984 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 41431009985 active site 41431009986 dimer interface [polypeptide binding]; other site 41431009987 catalytic nucleophile [active] 41431009988 hypothetical protein; Provisional; Region: PRK13686 41431009989 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 41431009990 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 41431009991 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 41431009992 Protein of unknown function (DUF433); Region: DUF433; cl01030 41431009993 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 41431009994 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 41431009995 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 41431009996 EamA-like transporter family; Region: EamA; pfam00892 41431009997 EamA-like transporter family; Region: EamA; pfam00892 41431009998 Repair protein; Region: Repair_PSII; pfam04536 41431009999 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 41431010000 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 41431010001 P loop; other site 41431010002 Nucleotide binding site [chemical binding]; other site 41431010003 DTAP/Switch II; other site 41431010004 Switch I; other site 41431010005 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 41431010006 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 41431010007 putative dimer interface [polypeptide binding]; other site 41431010008 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 41431010009 carotene isomerase; Region: carot_isom; TIGR02730 41431010010 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 41431010011 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 41431010012 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 41431010013 Predicted membrane protein [Function unknown]; Region: COG3431 41431010014 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 41431010015 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 41431010016 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 41431010017 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 41431010018 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 41431010019 CHASE2 domain; Region: CHASE2; pfam05226 41431010020 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 41431010021 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 41431010022 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 41431010023 ribonuclease Z; Region: RNase_Z; TIGR02651 41431010024 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431010025 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 41431010026 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 41431010027 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 41431010028 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 41431010029 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 41431010030 triosephosphate isomerase; Provisional; Region: PRK14565 41431010031 dimer interface [polypeptide binding]; other site 41431010032 substrate binding site [chemical binding]; other site 41431010033 catalytic triad [active] 41431010034 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 41431010035 putative catalytic residues [active] 41431010036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431010037 dimer interface [polypeptide binding]; other site 41431010038 conserved gate region; other site 41431010039 putative PBP binding loops; other site 41431010040 ABC-ATPase subunit interface; other site 41431010041 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 41431010042 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 41431010043 metal-binding site [ion binding] 41431010044 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 41431010045 Soluble P-type ATPase [General function prediction only]; Region: COG4087 41431010046 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 41431010047 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 41431010048 DNA binding residues [nucleotide binding] 41431010049 dimer interface [polypeptide binding]; other site 41431010050 metal binding site [ion binding]; metal-binding site 41431010051 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 41431010052 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 41431010053 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 41431010054 Multicopper oxidase; Region: Cu-oxidase; pfam00394 41431010055 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 41431010056 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431010057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010058 active site 41431010059 phosphorylation site [posttranslational modification] 41431010060 intermolecular recognition site; other site 41431010061 dimerization interface [polypeptide binding]; other site 41431010062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431010063 DNA binding site [nucleotide binding] 41431010064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431010065 dimer interface [polypeptide binding]; other site 41431010066 phosphorylation site [posttranslational modification] 41431010067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431010068 ATP binding site [chemical binding]; other site 41431010069 Mg2+ binding site [ion binding]; other site 41431010070 G-X-G motif; other site 41431010071 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 41431010072 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 41431010073 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 41431010074 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 41431010075 active site 41431010076 SAM binding site [chemical binding]; other site 41431010077 homodimer interface [polypeptide binding]; other site 41431010078 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 41431010079 conserved cys residue [active] 41431010080 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 41431010081 PemK-like protein; Region: PemK; pfam02452 41431010082 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 41431010083 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 41431010084 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431010085 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 41431010086 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 41431010087 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 41431010088 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 41431010089 dimer interface [polypeptide binding]; other site 41431010090 motif 1; other site 41431010091 active site 41431010092 motif 2; other site 41431010093 motif 3; other site 41431010094 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010095 putative active site [active] 41431010096 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 41431010097 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 41431010098 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 41431010099 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 41431010100 Flavoprotein; Region: Flavoprotein; pfam02441 41431010101 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 41431010102 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431010103 TIR domain; Region: TIR_2; pfam13676 41431010104 TPR repeat; Region: TPR_11; pfam13414 41431010105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431010106 binding surface 41431010107 TPR motif; other site 41431010108 TPR repeat; Region: TPR_11; pfam13414 41431010109 TPR repeat; Region: TPR_11; pfam13414 41431010110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431010111 binding surface 41431010112 TPR motif; other site 41431010113 TPR repeat; Region: TPR_11; pfam13414 41431010114 TPR repeat; Region: TPR_11; pfam13414 41431010115 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 41431010116 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 41431010117 tRNA; other site 41431010118 putative tRNA binding site [nucleotide binding]; other site 41431010119 putative NADP binding site [chemical binding]; other site 41431010120 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 41431010121 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 41431010122 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 41431010123 putative active site [active] 41431010124 PemK-like protein; Region: PemK; pfam02452 41431010125 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 41431010126 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 41431010127 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 41431010128 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 41431010129 nucleotide binding site [chemical binding]; other site 41431010130 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010131 putative active site [active] 41431010132 Immunoglobulin domain; Region: Ig; cl11960 41431010133 FOG: CBS domain [General function prediction only]; Region: COG0517 41431010134 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 41431010135 CP12 domain; Region: CP12; cl14670 41431010136 Staphylococcal nuclease homologues; Region: SNc; smart00318 41431010137 Catalytic site; other site 41431010138 Staphylococcal nuclease homologue; Region: SNase; pfam00565 41431010139 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 41431010140 putative active site [active] 41431010141 catalytic residue [active] 41431010142 hypothetical protein; Provisional; Region: PRK02724 41431010143 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 41431010144 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 41431010145 gamma subunit interface [polypeptide binding]; other site 41431010146 epsilon subunit interface [polypeptide binding]; other site 41431010147 LBP interface [polypeptide binding]; other site 41431010148 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 41431010149 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 41431010150 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 41431010151 alpha subunit interaction interface [polypeptide binding]; other site 41431010152 Walker A motif; other site 41431010153 ATP binding site [chemical binding]; other site 41431010154 Walker B motif; other site 41431010155 inhibitor binding site; inhibition site 41431010156 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 41431010157 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 41431010158 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 41431010159 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 41431010160 Zn2+ binding site [ion binding]; other site 41431010161 Mg2+ binding site [ion binding]; other site 41431010162 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 41431010163 nudix motif; other site 41431010164 argininosuccinate lyase; Provisional; Region: PRK00855 41431010165 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 41431010166 active sites [active] 41431010167 tetramer interface [polypeptide binding]; other site 41431010168 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431010169 GAF domain; Region: GAF_3; pfam13492 41431010170 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 41431010171 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 41431010172 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 41431010173 Response regulator receiver domain; Region: Response_reg; pfam00072 41431010174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010175 active site 41431010176 phosphorylation site [posttranslational modification] 41431010177 intermolecular recognition site; other site 41431010178 dimerization interface [polypeptide binding]; other site 41431010179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431010180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010181 active site 41431010182 phosphorylation site [posttranslational modification] 41431010183 intermolecular recognition site; other site 41431010184 dimerization interface [polypeptide binding]; other site 41431010185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431010186 DNA binding site [nucleotide binding] 41431010187 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431010188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010189 active site 41431010190 phosphorylation site [posttranslational modification] 41431010191 intermolecular recognition site; other site 41431010192 dimerization interface [polypeptide binding]; other site 41431010193 Response regulator receiver domain; Region: Response_reg; pfam00072 41431010194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010195 active site 41431010196 phosphorylation site [posttranslational modification] 41431010197 intermolecular recognition site; other site 41431010198 dimerization interface [polypeptide binding]; other site 41431010199 excinuclease ABC subunit B; Provisional; Region: PRK05298 41431010200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431010201 ATP binding site [chemical binding]; other site 41431010202 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431010203 nucleotide binding region [chemical binding]; other site 41431010204 ATP-binding site [chemical binding]; other site 41431010205 Ultra-violet resistance protein B; Region: UvrB; pfam12344 41431010206 UvrB/uvrC motif; Region: UVR; pfam02151 41431010207 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 41431010208 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 41431010209 HlyD family secretion protein; Region: HlyD_3; pfam13437 41431010210 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 41431010211 Protein export membrane protein; Region: SecD_SecF; cl14618 41431010212 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 41431010213 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 41431010214 active site 41431010215 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 41431010216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431010217 dimer interface [polypeptide binding]; other site 41431010218 conserved gate region; other site 41431010219 putative PBP binding loops; other site 41431010220 ABC-ATPase subunit interface; other site 41431010221 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 41431010222 NMT1-like family; Region: NMT1_2; pfam13379 41431010223 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 41431010224 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 41431010225 Walker A/P-loop; other site 41431010226 ATP binding site [chemical binding]; other site 41431010227 Q-loop/lid; other site 41431010228 ABC transporter signature motif; other site 41431010229 Walker B; other site 41431010230 D-loop; other site 41431010231 H-loop/switch region; other site 41431010232 AMIN domain; Region: AMIN; pfam11741 41431010233 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 41431010234 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 41431010235 active site 41431010236 metal binding site [ion binding]; metal-binding site 41431010237 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 41431010238 UbiA prenyltransferase family; Region: UbiA; pfam01040 41431010239 H+ Antiporter protein; Region: 2A0121; TIGR00900 41431010240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431010241 putative substrate translocation pore; other site 41431010242 Condensation domain; Region: Condensation; pfam00668 41431010243 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431010244 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 41431010245 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 41431010246 acyl-activating enzyme (AAE) consensus motif; other site 41431010247 AMP binding site [chemical binding]; other site 41431010248 PilZ domain; Region: PilZ; pfam07238 41431010249 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 41431010250 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431010251 Condensation domain; Region: Condensation; pfam00668 41431010252 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431010253 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 41431010254 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 41431010255 acyl-activating enzyme (AAE) consensus motif; other site 41431010256 AMP binding site [chemical binding]; other site 41431010257 PilZ domain; Region: PilZ; pfam07238 41431010258 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 41431010259 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431010260 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 41431010261 Condensation domain; Region: Condensation; pfam00668 41431010262 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431010263 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 41431010264 FkbH-like domain; Region: FkbH; TIGR01686 41431010265 HAD-superfamily phosphatase, subfamily IIIC; Region: HAD-SF-IIIC; TIGR01681 41431010266 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431010267 Condensation domain; Region: Condensation; pfam00668 41431010268 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431010269 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 41431010270 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 41431010271 acyl-activating enzyme (AAE) consensus motif; other site 41431010272 AMP binding site [chemical binding]; other site 41431010273 PilZ domain; Region: PilZ; pfam07238 41431010274 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 41431010275 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431010276 Condensation domain; Region: Condensation; pfam00668 41431010277 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431010278 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 41431010279 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 41431010280 acyl-activating enzyme (AAE) consensus motif; other site 41431010281 AMP binding site [chemical binding]; other site 41431010282 PilZ domain; Region: PilZ; pfam07238 41431010283 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 41431010284 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431010285 Condensation domain; Region: Condensation; pfam00668 41431010286 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 41431010287 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 41431010288 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 41431010289 acyl-activating enzyme (AAE) consensus motif; other site 41431010290 AMP binding site [chemical binding]; other site 41431010291 PilZ domain; Region: PilZ; pfam07238 41431010292 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 41431010293 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431010294 acyl-CoA synthetase; Validated; Region: PRK05850 41431010295 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 41431010296 acyl-activating enzyme (AAE) consensus motif; other site 41431010297 active site 41431010298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 41431010299 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 41431010300 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 41431010301 dimerization interface [polypeptide binding]; other site 41431010302 ATP binding site [chemical binding]; other site 41431010303 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 41431010304 dimerization interface [polypeptide binding]; other site 41431010305 ATP binding site [chemical binding]; other site 41431010306 Mrr N-terminal domain; Region: Mrr_N; pfam14338 41431010307 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 41431010308 Restriction endonuclease; Region: Mrr_cat; pfam04471 41431010309 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431010310 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 41431010311 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 41431010312 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 41431010313 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 41431010314 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 41431010315 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 41431010316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431010317 FeS/SAM binding site; other site 41431010318 TMAO/DMSO reductase; Reviewed; Region: PRK05363 41431010319 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 41431010320 Moco binding site; other site 41431010321 metal coordination site [ion binding]; other site 41431010322 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 41431010323 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 41431010324 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 41431010325 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 41431010326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431010327 motif II; other site 41431010328 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 41431010329 proton extrusion protein PcxA; Provisional; Region: PRK02507 41431010330 thioester reductase domain; Region: Thioester-redct; TIGR01746 41431010331 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 41431010332 putative NAD(P) binding site [chemical binding]; other site 41431010333 active site 41431010334 putative substrate binding site [chemical binding]; other site 41431010335 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 41431010336 dimerization interface [polypeptide binding]; other site 41431010337 putative DNA binding site [nucleotide binding]; other site 41431010338 putative Zn2+ binding site [ion binding]; other site 41431010339 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431010340 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010341 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010342 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010343 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431010344 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010345 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010346 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 41431010347 diiron binding motif [ion binding]; other site 41431010348 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 41431010349 active site 41431010350 catalytic residues [active] 41431010351 PemK-like protein; Region: PemK; pfam02452 41431010352 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 41431010353 dinuclear metal binding motif [ion binding]; other site 41431010354 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 41431010355 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 41431010356 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 41431010357 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 41431010358 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942 41431010359 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 41431010360 generic binding surface I; other site 41431010361 generic binding surface II; other site 41431010362 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 41431010363 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 41431010364 Probable Catalytic site; other site 41431010365 metal-binding site 41431010366 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 41431010367 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 41431010368 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 41431010369 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 41431010370 putative NAD(P) binding site [chemical binding]; other site 41431010371 active site 41431010372 HEAT repeats; Region: HEAT_2; pfam13646 41431010373 HEAT repeats; Region: HEAT_2; pfam13646 41431010374 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 41431010375 HEAT repeats; Region: HEAT_2; pfam13646 41431010376 aromatic acid decarboxylase; Validated; Region: PRK05920 41431010377 Flavoprotein; Region: Flavoprotein; pfam02441 41431010378 ubiquitin-activating enzyme E1; Region: Ube1; TIGR01408 41431010379 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 41431010380 catalytic triad [active] 41431010381 conserved cis-peptide bond; other site 41431010382 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431010383 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 41431010384 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 41431010385 putative NAD(P) binding site [chemical binding]; other site 41431010386 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431010387 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 41431010388 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 41431010389 active site 41431010390 dimer interface [polypeptide binding]; other site 41431010391 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 41431010392 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 41431010393 active site 41431010394 FMN binding site [chemical binding]; other site 41431010395 substrate binding site [chemical binding]; other site 41431010396 3Fe-4S cluster binding site [ion binding]; other site 41431010397 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 41431010398 domain interface; other site 41431010399 Protein of unknown function (DUF497); Region: DUF497; cl01108 41431010400 Protein of unknown function (DUF3680); Region: DUF3680; pfam12441 41431010401 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 41431010402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431010403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 41431010404 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010405 putative active site [active] 41431010406 Phycobilisome protein; Region: Phycobilisome; cl08227 41431010407 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 41431010408 DHH family; Region: DHH; pfam01368 41431010409 FOG: CBS domain [General function prediction only]; Region: COG0517 41431010410 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 41431010411 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 41431010412 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 41431010413 active site 41431010414 NTP binding site [chemical binding]; other site 41431010415 metal binding triad [ion binding]; metal-binding site 41431010416 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 41431010417 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 41431010418 GIY-YIG motif/motif A; other site 41431010419 active site 41431010420 catalytic site [active] 41431010421 metal binding site [ion binding]; metal-binding site 41431010422 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 41431010423 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 41431010424 Probable Catalytic site; other site 41431010425 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 41431010426 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431010427 putative metal binding site [ion binding]; other site 41431010428 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 41431010429 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 41431010430 active site 41431010431 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 41431010432 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 41431010433 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 41431010434 putative dimer interface [polypeptide binding]; other site 41431010435 N-terminal domain interface [polypeptide binding]; other site 41431010436 putative substrate binding pocket (H-site) [chemical binding]; other site 41431010437 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 41431010438 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 41431010439 Walker A/P-loop; other site 41431010440 ATP binding site [chemical binding]; other site 41431010441 Q-loop/lid; other site 41431010442 ABC transporter signature motif; other site 41431010443 Walker B; other site 41431010444 D-loop; other site 41431010445 H-loop/switch region; other site 41431010446 DevC protein; Region: devC; TIGR01185 41431010447 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 41431010448 FtsX-like permease family; Region: FtsX; pfam02687 41431010449 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 41431010450 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 41431010451 HlyD family secretion protein; Region: HlyD_3; pfam13437 41431010452 Response regulator receiver domain; Region: Response_reg; pfam00072 41431010453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010454 active site 41431010455 phosphorylation site [posttranslational modification] 41431010456 intermolecular recognition site; other site 41431010457 dimerization interface [polypeptide binding]; other site 41431010458 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 41431010459 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 41431010460 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 41431010461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010462 active site 41431010463 phosphorylation site [posttranslational modification] 41431010464 intermolecular recognition site; other site 41431010465 dimerization interface [polypeptide binding]; other site 41431010466 CheB methylesterase; Region: CheB_methylest; pfam01339 41431010467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 41431010468 Uncharacterized conserved protein [Function unknown]; Region: COG5439 41431010469 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 41431010470 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 41431010471 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 41431010472 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 41431010473 P loop; other site 41431010474 GTP binding site [chemical binding]; other site 41431010475 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 41431010476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431010477 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 41431010478 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 41431010479 substrate binding site [chemical binding]; other site 41431010480 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010481 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431010482 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010483 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010484 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010485 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010486 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010487 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010488 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 41431010489 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 41431010490 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 41431010491 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 41431010492 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 41431010493 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 41431010494 Response regulator receiver domain; Region: Response_reg; pfam00072 41431010495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010496 active site 41431010497 phosphorylation site [posttranslational modification] 41431010498 intermolecular recognition site; other site 41431010499 dimerization interface [polypeptide binding]; other site 41431010500 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431010501 GAF domain; Region: GAF; pfam01590 41431010502 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431010503 metal binding site [ion binding]; metal-binding site 41431010504 active site 41431010505 I-site; other site 41431010506 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 41431010507 MutS domain III; Region: MutS_III; pfam05192 41431010508 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 41431010509 Walker A/P-loop; other site 41431010510 ATP binding site [chemical binding]; other site 41431010511 Q-loop/lid; other site 41431010512 ABC transporter signature motif; other site 41431010513 Walker B; other site 41431010514 D-loop; other site 41431010515 H-loop/switch region; other site 41431010516 Smr domain; Region: Smr; pfam01713 41431010517 Methyltransferase domain; Region: Methyltransf_26; pfam13659 41431010518 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 41431010519 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 41431010520 Predicted transcriptional regulators [Transcription]; Region: COG1725 41431010521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 41431010522 DNA-binding site [nucleotide binding]; DNA binding site 41431010523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431010524 dimer interface [polypeptide binding]; other site 41431010525 conserved gate region; other site 41431010526 ABC-ATPase subunit interface; other site 41431010527 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 41431010528 META domain; Region: META; pfam03724 41431010529 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 41431010530 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 41431010531 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 41431010532 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 41431010533 C-terminal domain interface [polypeptide binding]; other site 41431010534 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 41431010535 dimer interface [polypeptide binding]; other site 41431010536 N-terminal domain interface [polypeptide binding]; other site 41431010537 substrate binding pocket (H-site) [chemical binding]; other site 41431010538 Predicted membrane protein [Function unknown]; Region: COG2259 41431010539 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 41431010540 DNA primase; Validated; Region: dnaG; PRK05667 41431010541 CHC2 zinc finger; Region: zf-CHC2; pfam01807 41431010542 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 41431010543 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 41431010544 active site 41431010545 metal binding site [ion binding]; metal-binding site 41431010546 interdomain interaction site; other site 41431010547 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 41431010548 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 41431010549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 41431010550 DNA-binding site [nucleotide binding]; DNA binding site 41431010551 UTRA domain; Region: UTRA; pfam07702 41431010552 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 41431010553 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431010554 Walker A/P-loop; other site 41431010555 ATP binding site [chemical binding]; other site 41431010556 Q-loop/lid; other site 41431010557 ABC transporter signature motif; other site 41431010558 Walker B; other site 41431010559 D-loop; other site 41431010560 H-loop/switch region; other site 41431010561 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 41431010562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 41431010563 Walker A/P-loop; other site 41431010564 ATP binding site [chemical binding]; other site 41431010565 Q-loop/lid; other site 41431010566 ABC transporter signature motif; other site 41431010567 Walker B; other site 41431010568 D-loop; other site 41431010569 H-loop/switch region; other site 41431010570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 41431010571 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 41431010572 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 41431010573 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 41431010574 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 41431010575 DNA binding residues [nucleotide binding] 41431010576 dimer interface [polypeptide binding]; other site 41431010577 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 41431010578 homodimer interface [polypeptide binding]; other site 41431010579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431010580 catalytic residue [active] 41431010581 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 41431010582 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010583 putative active site [active] 41431010584 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 41431010585 Catalytic NodB homology domain of uncharacterized chitin deacetylases and hypothetical proteins; Region: CE4_NodB_like_2; cd10958 41431010586 NodB motif; other site 41431010587 putative active site [active] 41431010588 putative catalytic site [active] 41431010589 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 41431010590 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 41431010591 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 41431010592 HSP70 interaction site [polypeptide binding]; other site 41431010593 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 41431010594 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 41431010595 Rrf2 family protein; Region: rrf2_super; TIGR00738 41431010596 Transcriptional regulator; Region: Rrf2; cl17282 41431010597 Uncharacterized conserved protein [Function unknown]; Region: COG3791 41431010598 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 41431010599 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 41431010600 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 41431010601 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 41431010602 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 41431010603 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 41431010604 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 41431010605 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 41431010606 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 41431010607 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 41431010608 Uncharacterized conserved protein [Function unknown]; Region: COG1565 41431010609 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 41431010610 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 41431010611 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 41431010612 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 41431010613 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 41431010614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431010615 S-adenosylmethionine binding site [chemical binding]; other site 41431010616 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 41431010617 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431010618 active site 41431010619 metal binding site [ion binding]; metal-binding site 41431010620 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 41431010621 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 41431010622 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 41431010623 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 41431010624 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 41431010625 Ligand Binding Site [chemical binding]; other site 41431010626 Universal stress protein family; Region: Usp; pfam00582 41431010627 Uncharacterized conserved protein [Function unknown]; Region: COG1434 41431010628 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 41431010629 putative active site [active] 41431010630 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 41431010631 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431010632 putative metal binding site; other site 41431010633 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 41431010634 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 41431010635 putative active site [active] 41431010636 TIGR03790 family protein; Region: TIGR03790 41431010637 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 41431010638 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 41431010639 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 41431010640 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 41431010641 pore gating glutamate residue; other site 41431010642 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 41431010643 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431010644 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 41431010645 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 41431010646 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 41431010647 putative active site [active] 41431010648 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 41431010649 putative active site [active] 41431010650 Cytochrome c; Region: Cytochrom_C; cl11414 41431010651 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 41431010652 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010653 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 41431010654 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 41431010655 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 41431010656 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 41431010657 RDD family; Region: RDD; pfam06271 41431010658 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 41431010659 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 41431010660 putative active site cavity [active] 41431010661 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 41431010662 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431010663 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431010664 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 41431010665 dimer interface [polypeptide binding]; other site 41431010666 active site 41431010667 metal binding site [ion binding]; metal-binding site 41431010668 glutathione binding site [chemical binding]; other site 41431010669 DALR anticodon binding domain; Region: DALR_1; smart00836 41431010670 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 41431010671 pheophytin binding site; other site 41431010672 chlorophyll binding site; other site 41431010673 quinone binding site; other site 41431010674 Fe binding site [ion binding]; other site 41431010675 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010676 putative active site [active] 41431010677 tellurium resistance terB-like protein; Region: terB_like; cd07177 41431010678 metal binding site [ion binding]; metal-binding site 41431010679 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 41431010680 G1 box; other site 41431010681 GTP/Mg2+ binding site [chemical binding]; other site 41431010682 G2 box; other site 41431010683 Switch I region; other site 41431010684 G3 box; other site 41431010685 Switch II region; other site 41431010686 G4 box; other site 41431010687 G5 box; other site 41431010688 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 41431010689 G1 box; other site 41431010690 GTP/Mg2+ binding site [chemical binding]; other site 41431010691 G2 box; other site 41431010692 G3 box; other site 41431010693 Switch II region; other site 41431010694 G4 box; other site 41431010695 G5 box; other site 41431010696 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 41431010697 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 41431010698 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 41431010699 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 41431010700 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 41431010701 active site 41431010702 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 41431010703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431010704 dimer interface [polypeptide binding]; other site 41431010705 conserved gate region; other site 41431010706 putative PBP binding loops; other site 41431010707 ABC-ATPase subunit interface; other site 41431010708 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 41431010709 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 41431010710 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 41431010711 Walker A/P-loop; other site 41431010712 ATP binding site [chemical binding]; other site 41431010713 Q-loop/lid; other site 41431010714 ABC transporter signature motif; other site 41431010715 Walker B; other site 41431010716 D-loop; other site 41431010717 H-loop/switch region; other site 41431010718 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431010719 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010720 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010721 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010722 multifunctional aminopeptidase A; Provisional; Region: PRK00913 41431010723 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 41431010724 interface (dimer of trimers) [polypeptide binding]; other site 41431010725 Substrate-binding/catalytic site; other site 41431010726 Zn-binding sites [ion binding]; other site 41431010727 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 41431010728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431010729 S-adenosylmethionine binding site [chemical binding]; other site 41431010730 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431010731 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431010732 structural tetrad; other site 41431010733 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 41431010734 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 41431010735 catalytic residues [active] 41431010736 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 41431010737 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 41431010738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431010739 homodimer interface [polypeptide binding]; other site 41431010740 catalytic residue [active] 41431010741 hypothetical protein; Reviewed; Region: PRK12497 41431010742 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 41431010743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 41431010744 non-specific DNA binding site [nucleotide binding]; other site 41431010745 salt bridge; other site 41431010746 sequence-specific DNA binding site [nucleotide binding]; other site 41431010747 DNA methylase; Region: N6_N4_Mtase; cl17433 41431010748 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431010749 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010750 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431010751 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 41431010752 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 41431010753 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 41431010754 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 41431010755 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 41431010756 putative NAD(P) binding site [chemical binding]; other site 41431010757 active site 41431010758 putative substrate binding site [chemical binding]; other site 41431010759 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431010760 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431010761 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 41431010762 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 41431010763 active site 41431010764 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 41431010765 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 41431010766 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 41431010767 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 41431010768 Walker A/P-loop; other site 41431010769 ATP binding site [chemical binding]; other site 41431010770 Q-loop/lid; other site 41431010771 ABC transporter signature motif; other site 41431010772 Walker B; other site 41431010773 D-loop; other site 41431010774 H-loop/switch region; other site 41431010775 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 41431010776 putative carbohydrate binding site [chemical binding]; other site 41431010777 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 41431010778 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 41431010779 G8 domain; Region: G8; pfam10162 41431010780 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 41431010781 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 41431010782 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 41431010783 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 41431010784 Ligand binding site; other site 41431010785 Putative Catalytic site; other site 41431010786 DXD motif; other site 41431010787 Predicted membrane protein [Function unknown]; Region: COG2246 41431010788 GtrA-like protein; Region: GtrA; pfam04138 41431010789 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 41431010790 propionate/acetate kinase; Provisional; Region: PRK12379 41431010791 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 41431010792 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 41431010793 putative metal binding residues [ion binding]; other site 41431010794 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 41431010795 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 41431010796 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 41431010797 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 41431010798 ABC-ATPase subunit interface; other site 41431010799 dimer interface [polypeptide binding]; other site 41431010800 putative PBP binding regions; other site 41431010801 Major royal jelly protein; Region: MRJP; pfam03022 41431010802 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 41431010803 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 41431010804 DNA binding residues [nucleotide binding] 41431010805 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 41431010806 catalytic residues [active] 41431010807 catalytic nucleophile [active] 41431010808 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431010809 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431010810 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010811 putative active site [active] 41431010812 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 41431010813 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 41431010814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431010815 binding surface 41431010816 TPR motif; other site 41431010817 Tetratricopeptide repeat; Region: TPR_16; pfam13432 41431010818 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 41431010819 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 41431010820 Lipase (class 2); Region: Lipase_2; pfam01674 41431010821 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 41431010822 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 41431010823 inhibitor-cofactor binding pocket; inhibition site 41431010824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431010825 catalytic residue [active] 41431010826 Transposase IS200 like; Region: Y1_Tnp; pfam01797 41431010827 Probable transposase; Region: OrfB_IS605; pfam01385 41431010828 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431010829 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431010830 PIN domain; Region: PIN; pfam01850 41431010831 TROVE domain; Region: TROVE; pfam05731 41431010832 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 41431010833 metal ion-dependent adhesion site (MIDAS); other site 41431010834 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 41431010835 active site 41431010836 dimer interface [polypeptide binding]; other site 41431010837 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 41431010838 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 41431010839 toxin interface [polypeptide binding]; other site 41431010840 Zn binding site [ion binding]; other site 41431010841 Abi-like protein; Region: Abi_2; cl01988 41431010842 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 41431010843 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 41431010844 dimer interface [polypeptide binding]; other site 41431010845 PYR/PP interface [polypeptide binding]; other site 41431010846 TPP binding site [chemical binding]; other site 41431010847 substrate binding site [chemical binding]; other site 41431010848 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 41431010849 Domain of unknown function; Region: EKR; pfam10371 41431010850 4Fe-4S binding domain; Region: Fer4_6; pfam12837 41431010851 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 41431010852 TPP-binding site [chemical binding]; other site 41431010853 dimer interface [polypeptide binding]; other site 41431010854 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 41431010855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 41431010856 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 41431010857 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 41431010858 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010859 putative active site [active] 41431010860 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 41431010861 catalytic residues [active] 41431010862 dimer interface [polypeptide binding]; other site 41431010863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431010864 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431010865 putative active site [active] 41431010866 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 41431010867 NADH(P)-binding; Region: NAD_binding_10; pfam13460 41431010868 NAD(P) binding site [chemical binding]; other site 41431010869 putative active site [active] 41431010870 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 41431010871 6-phosphofructokinase; Provisional; Region: PRK14071 41431010872 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 41431010873 active site 41431010874 fructose-1,6-bisphosphate binding site; other site 41431010875 dimerization interface [polypeptide binding]; other site 41431010876 allosteric effector site; other site 41431010877 phosphoribulokinase; Provisional; Region: PRK07429 41431010878 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 41431010879 active site 41431010880 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431010881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010882 active site 41431010883 phosphorylation site [posttranslational modification] 41431010884 intermolecular recognition site; other site 41431010885 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 41431010886 tetramer interface [polypeptide binding]; other site 41431010887 dimer interface [polypeptide binding]; other site 41431010888 circadian clock protein KaiC; Reviewed; Region: PRK09302 41431010889 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 41431010890 Walker A motif; other site 41431010891 ATP binding site [chemical binding]; other site 41431010892 Walker B motif; other site 41431010893 recA bacterial DNA recombination protein; Region: RecA; cl17211 41431010894 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 41431010895 Walker A motif; other site 41431010896 ATP binding site [chemical binding]; other site 41431010897 Walker B motif; other site 41431010898 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 41431010899 HsdM N-terminal domain; Region: HsdM_N; pfam12161 41431010900 Methyltransferase domain; Region: Methyltransf_26; pfam13659 41431010901 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 41431010902 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 41431010903 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 41431010904 oligomeric interface; other site 41431010905 putative active site [active] 41431010906 homodimer interface [polypeptide binding]; other site 41431010907 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431010908 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 41431010909 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 41431010910 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 41431010911 oligomeric interface; other site 41431010912 putative active site [active] 41431010913 homodimer interface [polypeptide binding]; other site 41431010914 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 41431010915 phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418 41431010916 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 41431010917 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 41431010918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431010919 Probable transposase; Region: OrfB_IS605; pfam01385 41431010920 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431010921 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 41431010922 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 41431010923 glutaminase active site [active] 41431010924 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 41431010925 dimer interface [polypeptide binding]; other site 41431010926 active site 41431010927 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 41431010928 dimer interface [polypeptide binding]; other site 41431010929 active site 41431010930 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 41431010931 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 41431010932 Integrase core domain; Region: rve; pfam00665 41431010933 AAA domain; Region: AAA_22; pfam13401 41431010934 TniQ; Region: TniQ; pfam06527 41431010935 DDE superfamily endonuclease; Region: DDE_3; pfam13358 41431010936 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 41431010937 Transposase [DNA replication, recombination, and repair]; Region: COG5433 41431010938 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 41431010939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431010940 Coenzyme A binding pocket [chemical binding]; other site 41431010941 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 41431010942 hypothetical protein; Provisional; Region: PRK06753 41431010943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 41431010944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 41431010945 FOG: CBS domain [General function prediction only]; Region: COG0517 41431010946 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 41431010947 TPR repeat; Region: TPR_11; pfam13414 41431010948 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 41431010949 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 41431010950 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 41431010951 active site 41431010952 catalytic residues [active] 41431010953 metal binding site [ion binding]; metal-binding site 41431010954 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 41431010955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 41431010956 NAD(P) binding site [chemical binding]; other site 41431010957 active site 41431010958 hypothetical protein; Provisional; Region: PRK06847 41431010959 hypothetical protein; Provisional; Region: PRK07236 41431010960 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 41431010961 isocitrate dehydrogenase; Validated; Region: PRK07362 41431010962 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 41431010963 5' RNA guide strand anchoring site; other site 41431010964 active site 41431010965 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 41431010966 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 41431010967 DNA binding residues [nucleotide binding] 41431010968 putative dimer interface [polypeptide binding]; other site 41431010969 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 41431010970 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 41431010971 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 41431010972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431010973 Walker A/P-loop; other site 41431010974 ATP binding site [chemical binding]; other site 41431010975 Q-loop/lid; other site 41431010976 ABC transporter signature motif; other site 41431010977 Walker B; other site 41431010978 D-loop; other site 41431010979 H-loop/switch region; other site 41431010980 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 41431010981 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 41431010982 S4 RNA-binding domain; Region: S4; smart00363 41431010983 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 41431010984 active site 41431010985 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 41431010986 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431010987 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431010988 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 41431010989 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 41431010990 DsrH like protein; Region: DsrH; cl17347 41431010991 DsrE/DsrF-like family; Region: DrsE; cl00672 41431010992 DsrH like protein; Region: DsrH; cl17347 41431010993 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431010994 Ligand Binding Site [chemical binding]; other site 41431010995 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431010996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431010997 active site 41431010998 phosphorylation site [posttranslational modification] 41431010999 intermolecular recognition site; other site 41431011000 dimerization interface [polypeptide binding]; other site 41431011001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431011002 DNA binding site [nucleotide binding] 41431011003 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 41431011004 OstA-like protein; Region: OstA; cl00844 41431011005 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 41431011006 Uncharacterized conserved protein [Function unknown]; Region: COG1432 41431011007 LabA_like proteins; Region: LabA; cd10911 41431011008 putative metal binding site [ion binding]; other site 41431011009 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 41431011010 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 41431011011 active site 41431011012 HIGH motif; other site 41431011013 KMSKS motif; other site 41431011014 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 41431011015 anticodon binding site; other site 41431011016 tRNA binding surface [nucleotide binding]; other site 41431011017 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 41431011018 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 41431011019 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 41431011020 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 41431011021 active site 41431011022 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 41431011023 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 41431011024 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 41431011025 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 41431011026 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 41431011027 ligand-binding site [chemical binding]; other site 41431011028 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 41431011029 Leucine-rich repeats; other site 41431011030 Leucine rich repeat; Region: LRR_8; pfam13855 41431011031 Substrate binding site [chemical binding]; other site 41431011032 Leucine rich repeat; Region: LRR_8; pfam13855 41431011033 Leucine rich repeat; Region: LRR_8; pfam13855 41431011034 Leucine rich repeat; Region: LRR_8; pfam13855 41431011035 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 41431011036 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 41431011037 G1 box; other site 41431011038 GTP/Mg2+ binding site [chemical binding]; other site 41431011039 G2 box; other site 41431011040 Switch I region; other site 41431011041 G3 box; other site 41431011042 Switch II region; other site 41431011043 G4 box; other site 41431011044 G5 box; other site 41431011045 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 41431011046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431011047 active site 41431011048 motif I; other site 41431011049 motif II; other site 41431011050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431011051 Methyltransferase domain; Region: Methyltransf_31; pfam13847 41431011052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431011053 S-adenosylmethionine binding site [chemical binding]; other site 41431011054 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 41431011055 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 41431011056 FtsX-like permease family; Region: FtsX; pfam02687 41431011057 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 41431011058 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 41431011059 DDE superfamily endonuclease; Region: DDE_4; pfam13359 41431011060 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431011061 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 41431011062 glutathione synthetase; Provisional; Region: PRK05246 41431011063 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 41431011064 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 41431011065 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 41431011066 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 41431011067 Helix-turn-helix domain; Region: HTH_25; pfam13413 41431011068 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 41431011069 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 41431011070 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 41431011071 active site 41431011072 hydrophilic channel; other site 41431011073 dimerization interface [polypeptide binding]; other site 41431011074 catalytic residues [active] 41431011075 active site lid [active] 41431011076 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 41431011077 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431011078 putative binding surface; other site 41431011079 active site 41431011080 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 41431011081 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 41431011082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431011083 ATP binding site [chemical binding]; other site 41431011084 Mg2+ binding site [ion binding]; other site 41431011085 G-X-G motif; other site 41431011086 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431011087 Response regulator receiver domain; Region: Response_reg; pfam00072 41431011088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431011089 active site 41431011090 phosphorylation site [posttranslational modification] 41431011091 intermolecular recognition site; other site 41431011092 dimerization interface [polypeptide binding]; other site 41431011093 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431011094 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431011095 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431011096 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431011097 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431011098 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431011099 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431011100 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431011101 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431011102 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431011103 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431011104 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431011105 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 41431011106 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 41431011107 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431011108 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 41431011109 dimer interface [polypeptide binding]; other site 41431011110 putative CheW interface [polypeptide binding]; other site 41431011111 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 41431011112 Response regulator receiver domain; Region: Response_reg; pfam00072 41431011113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431011114 active site 41431011115 phosphorylation site [posttranslational modification] 41431011116 intermolecular recognition site; other site 41431011117 dimerization interface [polypeptide binding]; other site 41431011118 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 41431011119 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 41431011120 homotetramer interface [polypeptide binding]; other site 41431011121 FMN binding site [chemical binding]; other site 41431011122 homodimer contacts [polypeptide binding]; other site 41431011123 putative active site [active] 41431011124 putative substrate binding site [chemical binding]; other site 41431011125 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431011126 Ligand Binding Site [chemical binding]; other site 41431011127 PhoD-like phosphatase; Region: PhoD; pfam09423 41431011128 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 41431011129 putative active site [active] 41431011130 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431011131 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 41431011132 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 41431011133 putative dimer interface [polypeptide binding]; other site 41431011134 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 41431011135 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 41431011136 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 41431011137 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 41431011138 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 41431011139 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 41431011140 MoaE interaction surface [polypeptide binding]; other site 41431011141 thiocarboxylated glycine; other site 41431011142 threonine synthase; Validated; Region: PRK07591 41431011143 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 41431011144 homodimer interface [polypeptide binding]; other site 41431011145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431011146 catalytic residue [active] 41431011147 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431011148 putative active site [active] 41431011149 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 41431011150 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 41431011151 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 41431011152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 41431011153 Transposase; Region: HTH_Tnp_1; cl17663 41431011154 Transposase; Region: DDE_Tnp_ISL3; pfam01610 41431011155 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 41431011156 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431011157 active site 41431011158 ATP binding site [chemical binding]; other site 41431011159 substrate binding site [chemical binding]; other site 41431011160 activation loop (A-loop); other site 41431011161 Uncharacterized conserved protein [Function unknown]; Region: COG1262 41431011162 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 41431011163 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 41431011164 acyl-CoA synthetase; Validated; Region: PRK05850 41431011165 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 41431011166 acyl-activating enzyme (AAE) consensus motif; other site 41431011167 active site 41431011168 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 41431011169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 41431011170 motif II; other site 41431011171 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 41431011172 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 41431011173 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 41431011174 active site 41431011175 substrate-binding site [chemical binding]; other site 41431011176 metal-binding site [ion binding] 41431011177 ATP binding site [chemical binding]; other site 41431011178 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 41431011179 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 41431011180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 41431011181 catalytic residue [active] 41431011182 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 41431011183 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 41431011184 nucleotide binding site [chemical binding]; other site 41431011185 NEF interaction site [polypeptide binding]; other site 41431011186 SBD interface [polypeptide binding]; other site 41431011187 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 41431011188 Fe-S cluster binding site [ion binding]; other site 41431011189 active site 41431011190 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 41431011191 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 41431011192 Walker A/P-loop; other site 41431011193 ATP binding site [chemical binding]; other site 41431011194 Q-loop/lid; other site 41431011195 ABC transporter signature motif; other site 41431011196 Walker B; other site 41431011197 D-loop; other site 41431011198 H-loop/switch region; other site 41431011199 Bacterial SH3 domain; Region: SH3_3; pfam08239 41431011200 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 41431011201 putative hexamer interface [polypeptide binding]; other site 41431011202 putative hexagonal pore; other site 41431011203 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 41431011204 Hexamer interface [polypeptide binding]; other site 41431011205 Hexagonal pore residue; other site 41431011206 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 41431011207 TrkA-N domain; Region: TrkA_N; pfam02254 41431011208 TrkA-C domain; Region: TrkA_C; pfam02080 41431011209 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 41431011210 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 41431011211 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 41431011212 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 41431011213 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 41431011214 G-X-X-G motif; other site 41431011215 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 41431011216 RxxxH motif; other site 41431011217 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 41431011218 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 41431011219 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 41431011220 Bacterial PH domain; Region: DUF304; pfam03703 41431011221 ribonuclease P; Reviewed; Region: rnpA; PRK03031 41431011222 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 41431011223 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 41431011224 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 41431011225 ligand binding site; other site 41431011226 oligomer interface; other site 41431011227 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 41431011228 dimer interface [polypeptide binding]; other site 41431011229 N-terminal domain interface [polypeptide binding]; other site 41431011230 sulfate 1 binding site; other site 41431011231 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 41431011232 S-layer homology domain; Region: SLH; pfam00395 41431011233 S-layer homology domain; Region: SLH; pfam00395 41431011234 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 41431011235 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 41431011236 dimerization interface [polypeptide binding]; other site 41431011237 DPS ferroxidase diiron center [ion binding]; other site 41431011238 ion pore; other site 41431011239 PBP superfamily domain; Region: PBP_like_2; cl17296 41431011240 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 41431011241 Permease; Region: Permease; cl00510 41431011242 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 41431011243 Domain of unknown function DUF59; Region: DUF59; pfam01883 41431011244 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 41431011245 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 41431011246 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 41431011247 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431011248 putative binding surface; other site 41431011249 active site 41431011250 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 41431011251 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 41431011252 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 41431011253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431011254 FeS/SAM binding site; other site 41431011255 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 41431011256 Methyltransferase domain; Region: Methyltransf_31; pfam13847 41431011257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431011258 S-adenosylmethionine binding site [chemical binding]; other site 41431011259 GUN4-like; Region: GUN4; pfam05419 41431011260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 41431011261 conserved hypothetical protein; Region: TIGR03492 41431011262 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 41431011263 RimM N-terminal domain; Region: RimM; pfam01782 41431011264 PRC-barrel domain; Region: PRC; pfam05239 41431011265 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 41431011266 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 41431011267 ATP adenylyltransferase; Region: ATP_transf; pfam09830 41431011268 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 41431011269 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 41431011270 magnesium chelatase subunit H; Provisional; Region: PLN03241 41431011271 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 41431011272 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 41431011273 TRAM domain; Region: TRAM; pfam01938 41431011274 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 41431011275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431011276 S-adenosylmethionine binding site [chemical binding]; other site 41431011277 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 41431011278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 41431011279 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 41431011280 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 41431011281 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 41431011282 GTP/Mg2+ binding site [chemical binding]; other site 41431011283 G4 box; other site 41431011284 G5 box; other site 41431011285 G1 box; other site 41431011286 Switch I region; other site 41431011287 G2 box; other site 41431011288 G3 box; other site 41431011289 Switch II region; other site 41431011290 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 41431011291 ligand binding surface [chemical binding]; other site 41431011292 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 41431011293 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 41431011294 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 41431011295 Competence protein; Region: Competence; pfam03772 41431011296 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 41431011297 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 41431011298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431011299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431011300 dimer interface [polypeptide binding]; other site 41431011301 phosphorylation site [posttranslational modification] 41431011302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431011303 ATP binding site [chemical binding]; other site 41431011304 Mg2+ binding site [ion binding]; other site 41431011305 G-X-G motif; other site 41431011306 Uncharacterized conserved protein [Function unknown]; Region: COG0398 41431011307 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 41431011308 Creatinine amidohydrolase; Region: Creatininase; pfam02633 41431011309 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 41431011310 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 41431011311 S-formylglutathione hydrolase; Region: PLN02442 41431011312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 41431011313 PRC-barrel domain; Region: PRC; pfam05239 41431011314 PRC-barrel domain; Region: PRC; pfam05239 41431011315 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 41431011316 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 41431011317 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 41431011318 Domain of unknown function DUF21; Region: DUF21; pfam01595 41431011319 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 41431011320 Transporter associated domain; Region: CorC_HlyC; smart01091 41431011321 Chromate transporter; Region: Chromate_transp; pfam02417 41431011322 Chromate transporter; Region: Chromate_transp; pfam02417 41431011323 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 41431011324 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 41431011325 ThiS interaction site; other site 41431011326 putative active site [active] 41431011327 tetramer interface [polypeptide binding]; other site 41431011328 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 41431011329 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 41431011330 putative C-terminal domain interface [polypeptide binding]; other site 41431011331 putative GSH binding site (G-site) [chemical binding]; other site 41431011332 putative dimer interface [polypeptide binding]; other site 41431011333 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 41431011334 dimer interface [polypeptide binding]; other site 41431011335 N-terminal domain interface [polypeptide binding]; other site 41431011336 substrate binding pocket (H-site) [chemical binding]; other site 41431011337 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 41431011338 GAF domain; Region: GAF; pfam01590 41431011339 Phytochrome region; Region: PHY; pfam00360 41431011340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431011341 dimer interface [polypeptide binding]; other site 41431011342 phosphorylation site [posttranslational modification] 41431011343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431011344 ATP binding site [chemical binding]; other site 41431011345 Mg2+ binding site [ion binding]; other site 41431011346 G-X-G motif; other site 41431011347 Response regulator receiver domain; Region: Response_reg; pfam00072 41431011348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431011349 active site 41431011350 phosphorylation site [posttranslational modification] 41431011351 intermolecular recognition site; other site 41431011352 dimerization interface [polypeptide binding]; other site 41431011353 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 41431011354 Part of AAA domain; Region: AAA_19; pfam13245 41431011355 Family description; Region: UvrD_C_2; pfam13538 41431011356 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 41431011357 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 41431011358 catalytic residues [active] 41431011359 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 41431011360 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 41431011361 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 41431011362 active site 41431011363 homodimer interface [polypeptide binding]; other site 41431011364 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 41431011365 replicative DNA helicase; Region: DnaB; TIGR00665 41431011366 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 41431011367 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 41431011368 Walker A motif; other site 41431011369 ATP binding site [chemical binding]; other site 41431011370 Walker B motif; other site 41431011371 DNA binding loops [nucleotide binding] 41431011372 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 41431011373 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 41431011374 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 41431011375 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 41431011376 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431011377 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 41431011378 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431011379 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431011380 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431011381 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 41431011382 active site clefts [active] 41431011383 zinc binding site [ion binding]; other site 41431011384 dimer interface [polypeptide binding]; other site 41431011385 Probable transposase; Region: OrfB_IS605; pfam01385 41431011386 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 41431011387 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 41431011388 rod shape-determining protein MreC; Provisional; Region: PRK13922 41431011389 rod shape-determining protein MreC; Region: MreC; pfam04085 41431011390 rod shape-determining protein MreB; Provisional; Region: PRK13927 41431011391 MreB and similar proteins; Region: MreB_like; cd10225 41431011392 nucleotide binding site [chemical binding]; other site 41431011393 Mg binding site [ion binding]; other site 41431011394 putative protofilament interaction site [polypeptide binding]; other site 41431011395 RodZ interaction site [polypeptide binding]; other site 41431011396 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 41431011397 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 41431011398 dimer interface [polypeptide binding]; other site 41431011399 ssDNA binding site [nucleotide binding]; other site 41431011400 tetramer (dimer of dimers) interface [polypeptide binding]; other site 41431011401 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 41431011402 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 41431011403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431011404 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431011405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431011406 DNA binding residues [nucleotide binding] 41431011407 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 41431011408 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 41431011409 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 41431011410 metal binding site 2 [ion binding]; metal-binding site 41431011411 putative DNA binding helix; other site 41431011412 metal binding site 1 [ion binding]; metal-binding site 41431011413 dimer interface [polypeptide binding]; other site 41431011414 structural Zn2+ binding site [ion binding]; other site 41431011415 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 41431011416 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 41431011417 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 41431011418 putative active site [active] 41431011419 catalytic triad [active] 41431011420 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 41431011421 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 41431011422 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 41431011423 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431011424 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 41431011425 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 41431011426 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 41431011427 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 41431011428 DNA binding residues [nucleotide binding] 41431011429 dimerization interface [polypeptide binding]; other site 41431011430 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 41431011431 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 41431011432 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 41431011433 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 41431011434 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 41431011435 NAD binding site [chemical binding]; other site 41431011436 homodimer interface [polypeptide binding]; other site 41431011437 active site 41431011438 substrate binding site [chemical binding]; other site 41431011439 photosystem II reaction center protein J; Provisional; Region: PRK02565 41431011440 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 41431011441 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 41431011442 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 41431011443 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 41431011444 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 41431011445 Ycf48-like protein; Provisional; Region: PRK13684 41431011446 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 41431011447 Rubredoxin; Region: Rubredoxin; pfam00301 41431011448 iron binding site [ion binding]; other site 41431011449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 41431011450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 41431011451 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 41431011452 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 41431011453 tetramer interface [polypeptide binding]; other site 41431011454 TPP-binding site [chemical binding]; other site 41431011455 heterodimer interface [polypeptide binding]; other site 41431011456 phosphorylation loop region [posttranslational modification] 41431011457 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 41431011458 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 41431011459 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 41431011460 nucleotide binding site [chemical binding]; other site 41431011461 putative NEF/HSP70 interaction site [polypeptide binding]; other site 41431011462 SBD interface [polypeptide binding]; other site 41431011463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431011464 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431011465 Probable transposase; Region: OrfB_IS605; pfam01385 41431011466 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431011467 hypothetical protein; Provisional; Region: PRK02509 41431011468 Uncharacterized conserved protein [Function unknown]; Region: COG1615 41431011469 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 41431011470 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431011471 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 41431011472 Tetratricopeptide repeat; Region: TPR_1; pfam00515 41431011473 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 41431011474 GSH binding site [chemical binding]; other site 41431011475 catalytic residues [active] 41431011476 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 41431011477 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 41431011478 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 41431011479 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 41431011480 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 41431011481 active site 41431011482 catalytic site [active] 41431011483 CheB methylesterase; Region: CheB_methylest; pfam01339 41431011484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 41431011485 active site 41431011486 dimerization interface [polypeptide binding]; other site 41431011487 MraW methylase family; Region: Methyltransf_5; cl17771 41431011488 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 41431011489 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 41431011490 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 41431011491 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 41431011492 trmE is a tRNA modification GTPase; Region: trmE; cd04164 41431011493 G1 box; other site 41431011494 GTP/Mg2+ binding site [chemical binding]; other site 41431011495 Switch I region; other site 41431011496 G2 box; other site 41431011497 Switch II region; other site 41431011498 G3 box; other site 41431011499 G4 box; other site 41431011500 G5 box; other site 41431011501 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 41431011502 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 41431011503 HicB family; Region: HicB; pfam05534 41431011504 acetolactate synthase; Reviewed; Region: PRK08322 41431011505 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 41431011506 PYR/PP interface [polypeptide binding]; other site 41431011507 dimer interface [polypeptide binding]; other site 41431011508 TPP binding site [chemical binding]; other site 41431011509 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 41431011510 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 41431011511 TPP-binding site [chemical binding]; other site 41431011512 dimer interface [polypeptide binding]; other site 41431011513 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 41431011514 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 41431011515 NAD(P) binding site [chemical binding]; other site 41431011516 catalytic residues [active] 41431011517 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 41431011518 Secretin and TonB N terminus short domain; Region: STN; pfam07660 41431011519 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 41431011520 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 41431011521 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 41431011522 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 41431011523 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 41431011524 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 41431011525 Protein kinase domain; Region: Pkinase; pfam00069 41431011526 Catalytic domain of Protein Kinases; Region: PKc; cd00180 41431011527 active site 41431011528 ATP binding site [chemical binding]; other site 41431011529 substrate binding site [chemical binding]; other site 41431011530 activation loop (A-loop); other site 41431011531 amidophosphoribosyltransferase; Provisional; Region: PRK07349 41431011532 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 41431011533 active site 41431011534 tetramer interface [polypeptide binding]; other site 41431011535 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 41431011536 active site 41431011537 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 41431011538 DNA polymerase III subunit delta; Validated; Region: PRK07452 41431011539 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 41431011540 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 41431011541 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 41431011542 oligomer interface [polypeptide binding]; other site 41431011543 metal binding site [ion binding]; metal-binding site 41431011544 metal binding site [ion binding]; metal-binding site 41431011545 Cl binding site [ion binding]; other site 41431011546 aspartate ring; other site 41431011547 basic sphincter; other site 41431011548 putative hydrophobic gate; other site 41431011549 periplasmic entrance; other site 41431011550 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 41431011551 active site 41431011552 dimer interface [polypeptide binding]; other site 41431011553 metal binding site [ion binding]; metal-binding site 41431011554 S-layer homology domain; Region: SLH; pfam00395 41431011555 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 41431011556 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 41431011557 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 41431011558 Ligand Binding Site [chemical binding]; other site 41431011559 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 41431011560 MoaE interaction surface [polypeptide binding]; other site 41431011561 MoeB interaction surface [polypeptide binding]; other site 41431011562 thiocarboxylated glycine; other site 41431011563 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 41431011564 NADPH bind site [chemical binding]; other site 41431011565 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 41431011566 putative FMN binding site [chemical binding]; other site 41431011567 NADPH bind site [chemical binding]; other site 41431011568 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 41431011569 Mechanosensitive ion channel; Region: MS_channel; pfam00924 41431011570 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 41431011571 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431011572 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 41431011573 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 41431011574 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 41431011575 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 41431011576 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 41431011577 Protein of unknown function (DUF1626); Region: DUF1626; pfam07788 41431011578 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 41431011579 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 41431011580 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 41431011581 Phytase; Region: Phytase; cl17685 41431011582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431011583 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431011584 Probable transposase; Region: OrfB_IS605; pfam01385 41431011585 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431011586 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 41431011587 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 41431011588 G1 box; other site 41431011589 putative GEF interaction site [polypeptide binding]; other site 41431011590 GTP/Mg2+ binding site [chemical binding]; other site 41431011591 Switch I region; other site 41431011592 G2 box; other site 41431011593 G3 box; other site 41431011594 Switch II region; other site 41431011595 G4 box; other site 41431011596 G5 box; other site 41431011597 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 41431011598 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 41431011599 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 41431011600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 41431011601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 41431011602 Coenzyme A binding pocket [chemical binding]; other site 41431011603 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 41431011604 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 41431011605 G1 box; other site 41431011606 GTP/Mg2+ binding site [chemical binding]; other site 41431011607 G2 box; other site 41431011608 Switch I region; other site 41431011609 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 41431011610 G3 box; other site 41431011611 Switch II region; other site 41431011612 G4 box; other site 41431011613 KGK domain; Region: KGK; pfam08872 41431011614 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 41431011615 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 41431011616 active site 41431011617 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 41431011618 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 41431011619 putative acyl-acceptor binding pocket; other site 41431011620 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431011621 putative active site [active] 41431011622 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 41431011623 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 41431011624 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 41431011625 phosphopeptide binding site; other site 41431011626 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 41431011627 cyclase homology domain; Region: CHD; cd07302 41431011628 nucleotidyl binding site; other site 41431011629 metal binding site [ion binding]; metal-binding site 41431011630 dimer interface [polypeptide binding]; other site 41431011631 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 41431011632 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 41431011633 active site 41431011634 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 41431011635 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 41431011636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 41431011637 non-specific DNA binding site [nucleotide binding]; other site 41431011638 salt bridge; other site 41431011639 sequence-specific DNA binding site [nucleotide binding]; other site 41431011640 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 41431011641 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 41431011642 dimerization interface [polypeptide binding]; other site 41431011643 active site 41431011644 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 41431011645 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 41431011646 dimer interface [polypeptide binding]; other site 41431011647 decamer (pentamer of dimers) interface [polypeptide binding]; other site 41431011648 catalytic triad [active] 41431011649 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 41431011650 Family of unknown function (DUF490); Region: DUF490; pfam04357 41431011651 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 41431011652 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 41431011653 active site 41431011654 intersubunit interactions; other site 41431011655 catalytic residue [active] 41431011656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 41431011657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431011658 active site 41431011659 phosphorylation site [posttranslational modification] 41431011660 intermolecular recognition site; other site 41431011661 dimerization interface [polypeptide binding]; other site 41431011662 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 41431011663 DNA binding site [nucleotide binding] 41431011664 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 41431011665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431011666 dimer interface [polypeptide binding]; other site 41431011667 phosphorylation site [posttranslational modification] 41431011668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431011669 ATP binding site [chemical binding]; other site 41431011670 Mg2+ binding site [ion binding]; other site 41431011671 G-X-G motif; other site 41431011672 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 41431011673 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 41431011674 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 41431011675 FHA domain; Region: FHA; pfam00498 41431011676 phosphopeptide binding site; other site 41431011677 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 41431011678 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 41431011679 FAD binding pocket [chemical binding]; other site 41431011680 FAD binding motif [chemical binding]; other site 41431011681 phosphate binding motif [ion binding]; other site 41431011682 beta-alpha-beta structure motif; other site 41431011683 NAD binding pocket [chemical binding]; other site 41431011684 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 41431011685 catalytic loop [active] 41431011686 iron binding site [ion binding]; other site 41431011687 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 41431011688 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 41431011689 Walker A motif; other site 41431011690 ATP binding site [chemical binding]; other site 41431011691 Walker B motif; other site 41431011692 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 41431011693 ATP binding site [chemical binding]; other site 41431011694 Walker B motif; other site 41431011695 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 41431011696 tetramer interface [polypeptide binding]; other site 41431011697 dimer interface [polypeptide binding]; other site 41431011698 KaiA domain; Region: KaiA; pfam07688 41431011699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431011700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431011701 dimer interface [polypeptide binding]; other site 41431011702 phosphorylation site [posttranslational modification] 41431011703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431011704 ATP binding site [chemical binding]; other site 41431011705 Mg2+ binding site [ion binding]; other site 41431011706 G-X-G motif; other site 41431011707 Response regulator receiver domain; Region: Response_reg; pfam00072 41431011708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431011709 active site 41431011710 phosphorylation site [posttranslational modification] 41431011711 intermolecular recognition site; other site 41431011712 dimerization interface [polypeptide binding]; other site 41431011713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431011714 dimer interface [polypeptide binding]; other site 41431011715 conserved gate region; other site 41431011716 putative PBP binding loops; other site 41431011717 ABC-ATPase subunit interface; other site 41431011718 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 41431011719 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 41431011720 active site 41431011721 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 41431011722 active site 41431011723 TPR repeat; Region: TPR_11; pfam13414 41431011724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431011725 binding surface 41431011726 TPR motif; other site 41431011727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431011728 binding surface 41431011729 TPR repeat; Region: TPR_11; pfam13414 41431011730 TPR motif; other site 41431011731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 41431011732 binding surface 41431011733 Tetratricopeptide repeat; Region: TPR_16; pfam13432 41431011734 TPR motif; other site 41431011735 TPR repeat; Region: TPR_11; pfam13414 41431011736 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 41431011737 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 41431011738 putative catalytic residue [active] 41431011739 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 41431011740 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 41431011741 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 41431011742 DXD motif; other site 41431011743 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 41431011744 active site 41431011745 SAM binding site [chemical binding]; other site 41431011746 homodimer interface [polypeptide binding]; other site 41431011747 LabA_like proteins; Region: LabA_like; cd06167 41431011748 putative metal binding site [ion binding]; other site 41431011749 Uncharacterized conserved protein [Function unknown]; Region: COG1432 41431011750 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 41431011751 DNA-binding site [nucleotide binding]; DNA binding site 41431011752 RNA-binding motif; other site 41431011753 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 41431011754 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 41431011755 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 41431011756 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 41431011757 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 41431011758 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 41431011759 active site clefts [active] 41431011760 zinc binding site [ion binding]; other site 41431011761 dimer interface [polypeptide binding]; other site 41431011762 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 41431011763 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 41431011764 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 41431011765 Uncharacterized conserved protein [Function unknown]; Region: COG4748 41431011766 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 41431011767 cell division protein FtsZ; Validated; Region: PRK09330 41431011768 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 41431011769 nucleotide binding site [chemical binding]; other site 41431011770 SulA interaction site; other site 41431011771 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 41431011772 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 41431011773 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 41431011774 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 41431011775 C-terminal peptidase (prc); Region: prc; TIGR00225 41431011776 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 41431011777 protein binding site [polypeptide binding]; other site 41431011778 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 41431011779 Catalytic dyad [active] 41431011780 Ferritin-like domain; Region: Ferritin; pfam00210 41431011781 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 41431011782 dinuclear metal binding motif [ion binding]; other site 41431011783 Iron permease FTR1 family; Region: FTR1; cl00475 41431011784 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 41431011785 DDE superfamily endonuclease; Region: DDE_4; pfam13359 41431011786 Uncharacterized conserved protein [Function unknown]; Region: COG2947 41431011787 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 41431011788 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 41431011789 tetramer (dimer of dimers) interface [polypeptide binding]; other site 41431011790 active site 41431011791 dimer interface [polypeptide binding]; other site 41431011792 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 41431011793 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 41431011794 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 41431011795 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 41431011796 NAD(P) binding site [chemical binding]; other site 41431011797 homotetramer interface [polypeptide binding]; other site 41431011798 homodimer interface [polypeptide binding]; other site 41431011799 active site 41431011800 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 41431011801 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 41431011802 Walker A/P-loop; other site 41431011803 ATP binding site [chemical binding]; other site 41431011804 Q-loop/lid; other site 41431011805 ABC transporter signature motif; other site 41431011806 Walker B; other site 41431011807 D-loop; other site 41431011808 H-loop/switch region; other site 41431011809 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 41431011810 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 41431011811 Walker A/P-loop; other site 41431011812 ATP binding site [chemical binding]; other site 41431011813 Q-loop/lid; other site 41431011814 ABC transporter signature motif; other site 41431011815 Walker B; other site 41431011816 D-loop; other site 41431011817 H-loop/switch region; other site 41431011818 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 41431011819 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 41431011820 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 41431011821 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 41431011822 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431011823 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 41431011824 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 41431011825 putative ADP-binding pocket [chemical binding]; other site 41431011826 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431011827 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431011828 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 41431011829 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 41431011830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 41431011831 Walker A/P-loop; other site 41431011832 ATP binding site [chemical binding]; other site 41431011833 Q-loop/lid; other site 41431011834 ABC transporter signature motif; other site 41431011835 Walker B; other site 41431011836 D-loop; other site 41431011837 H-loop/switch region; other site 41431011838 Phosphotransferase enzyme family; Region: APH; pfam01636 41431011839 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 41431011840 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 41431011841 ligand binding site [chemical binding]; other site 41431011842 flexible hinge region; other site 41431011843 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 41431011844 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 41431011845 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 41431011846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431011847 FeS/SAM binding site; other site 41431011848 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 41431011849 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 41431011850 ATP binding site [chemical binding]; other site 41431011851 Mg++ binding site [ion binding]; other site 41431011852 motif III; other site 41431011853 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431011854 nucleotide binding region [chemical binding]; other site 41431011855 ATP-binding site [chemical binding]; other site 41431011856 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 41431011857 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 41431011858 active site residue [active] 41431011859 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 41431011860 active site residue [active] 41431011861 Sulphur transport; Region: Sulf_transp; pfam04143 41431011862 Sulphur transport; Region: Sulf_transp; pfam04143 41431011863 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 41431011864 classical (c) SDRs; Region: SDR_c; cd05233 41431011865 NAD(P) binding site [chemical binding]; other site 41431011866 active site 41431011867 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 41431011868 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 41431011869 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 41431011870 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 41431011871 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431011872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431011873 active site 41431011874 phosphorylation site [posttranslational modification] 41431011875 intermolecular recognition site; other site 41431011876 dimerization interface [polypeptide binding]; other site 41431011877 Response regulator receiver domain; Region: Response_reg; pfam00072 41431011878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431011879 active site 41431011880 phosphorylation site [posttranslational modification] 41431011881 intermolecular recognition site; other site 41431011882 dimerization interface [polypeptide binding]; other site 41431011883 CheW-like domain; Region: CheW; pfam01584 41431011884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 41431011885 dimerization interface [polypeptide binding]; other site 41431011886 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 41431011887 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 41431011888 dimer interface [polypeptide binding]; other site 41431011889 putative CheW interface [polypeptide binding]; other site 41431011890 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 41431011891 putative binding surface; other site 41431011892 active site 41431011893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431011894 ATP binding site [chemical binding]; other site 41431011895 Mg2+ binding site [ion binding]; other site 41431011896 G-X-G motif; other site 41431011897 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 41431011898 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 41431011899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431011900 active site 41431011901 phosphorylation site [posttranslational modification] 41431011902 intermolecular recognition site; other site 41431011903 dimerization interface [polypeptide binding]; other site 41431011904 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 41431011905 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431011906 putative active site [active] 41431011907 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 41431011908 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 41431011909 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 41431011910 active site 41431011911 substrate binding site [chemical binding]; other site 41431011912 trimer interface [polypeptide binding]; other site 41431011913 CoA binding site [chemical binding]; other site 41431011914 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 41431011915 substrate binding site; other site 41431011916 dimer interface; other site 41431011917 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431011918 cofactor binding site; other site 41431011919 DNA binding site [nucleotide binding] 41431011920 substrate interaction site [chemical binding]; other site 41431011921 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 41431011922 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 41431011923 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 41431011924 Transposase domain (DUF772); Region: DUF772; pfam05598 41431011925 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 41431011926 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 41431011927 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 41431011928 active site 41431011929 metal binding site [ion binding]; metal-binding site 41431011930 ATP cone domain; Region: ATP-cone; pfam03477 41431011931 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 41431011932 Class I ribonucleotide reductase; Region: RNR_I; cd01679 41431011933 active site 41431011934 dimer interface [polypeptide binding]; other site 41431011935 catalytic residues [active] 41431011936 effector binding site; other site 41431011937 R2 peptide binding site; other site 41431011938 Domain of unknown function DUF29; Region: DUF29; pfam01724 41431011939 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 41431011940 dimer interface [polypeptide binding]; other site 41431011941 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 41431011942 putative radical transfer pathway; other site 41431011943 diiron center [ion binding]; other site 41431011944 tyrosyl radical; other site 41431011945 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 41431011946 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 41431011947 homodimer interface [polypeptide binding]; other site 41431011948 substrate-cofactor binding pocket; other site 41431011949 Aminotransferase class IV; Region: Aminotran_4; pfam01063 41431011950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 41431011951 catalytic residue [active] 41431011952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431011953 BT1 family; Region: BT1; pfam03092 41431011954 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431011955 active site 41431011956 NTP binding site [chemical binding]; other site 41431011957 metal binding triad [ion binding]; metal-binding site 41431011958 antibiotic binding site [chemical binding]; other site 41431011959 cytochrome c-550; Provisional; Region: psbV; PRK13619 41431011960 GxxExxY protein; Region: GxxExxY; TIGR04256 41431011961 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 41431011962 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 41431011963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431011964 ATP binding site [chemical binding]; other site 41431011965 putative Mg++ binding site [ion binding]; other site 41431011966 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431011967 nucleotide binding region [chemical binding]; other site 41431011968 ATP-binding site [chemical binding]; other site 41431011969 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 41431011970 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 41431011971 Protein of unknown function (DUF433); Region: DUF433; pfam04255 41431011972 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431011973 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431011974 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 41431011975 magnesium chelatase subunit H; Provisional; Region: PRK12493 41431011976 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 41431011977 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 41431011978 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 41431011979 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 41431011980 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 41431011981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431011982 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 41431011983 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431011984 DNA binding residues [nucleotide binding] 41431011985 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 41431011986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431011987 dimer interface [polypeptide binding]; other site 41431011988 conserved gate region; other site 41431011989 putative PBP binding loops; other site 41431011990 ABC-ATPase subunit interface; other site 41431011991 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 41431011992 active site 41431011993 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 41431011994 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 41431011995 Tetratricopeptide repeat; Region: TPR_16; pfam13432 41431011996 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431011997 FeS/SAM binding site; other site 41431011998 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 41431011999 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 41431012000 active site 41431012001 intersubunit interface [polypeptide binding]; other site 41431012002 catalytic residue [active] 41431012003 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 41431012004 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 41431012005 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 41431012006 TIR domain; Region: TIR_2; pfam13676 41431012007 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431012008 putative active site [active] 41431012009 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 41431012010 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 41431012011 active site 41431012012 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 41431012013 active site 41431012014 NTP binding site [chemical binding]; other site 41431012015 metal binding triad [ion binding]; metal-binding site 41431012016 antibiotic binding site [chemical binding]; other site 41431012017 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 41431012018 GAF domain; Region: GAF_3; pfam13492 41431012019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 41431012020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431012021 dimer interface [polypeptide binding]; other site 41431012022 phosphorylation site [posttranslational modification] 41431012023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431012024 ATP binding site [chemical binding]; other site 41431012025 Mg2+ binding site [ion binding]; other site 41431012026 G-X-G motif; other site 41431012027 Response regulator receiver domain; Region: Response_reg; pfam00072 41431012028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431012029 active site 41431012030 phosphorylation site [posttranslational modification] 41431012031 intermolecular recognition site; other site 41431012032 dimerization interface [polypeptide binding]; other site 41431012033 PAS fold; Region: PAS_4; pfam08448 41431012034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431012035 PAS fold; Region: PAS_3; pfam08447 41431012036 putative active site [active] 41431012037 heme pocket [chemical binding]; other site 41431012038 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431012039 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431012040 metal binding site [ion binding]; metal-binding site 41431012041 active site 41431012042 I-site; other site 41431012043 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431012044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431012045 active site 41431012046 phosphorylation site [posttranslational modification] 41431012047 intermolecular recognition site; other site 41431012048 dimerization interface [polypeptide binding]; other site 41431012049 PAS domain S-box; Region: sensory_box; TIGR00229 41431012050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431012051 putative active site [active] 41431012052 heme pocket [chemical binding]; other site 41431012053 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 41431012054 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431012055 metal binding site [ion binding]; metal-binding site 41431012056 active site 41431012057 I-site; other site 41431012058 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431012059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 41431012060 Response regulator receiver domain; Region: Response_reg; pfam00072 41431012061 active site 41431012062 phosphorylation site [posttranslational modification] 41431012063 intermolecular recognition site; other site 41431012064 dimerization interface [polypeptide binding]; other site 41431012065 PAS fold; Region: PAS_4; pfam08448 41431012066 PAS fold; Region: PAS_4; pfam08448 41431012067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431012068 putative active site [active] 41431012069 heme pocket [chemical binding]; other site 41431012070 GAF domain; Region: GAF; cl17456 41431012071 PAS domain S-box; Region: sensory_box; TIGR00229 41431012072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431012073 putative active site [active] 41431012074 heme pocket [chemical binding]; other site 41431012075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431012076 PAS fold; Region: PAS_3; pfam08447 41431012077 putative active site [active] 41431012078 heme pocket [chemical binding]; other site 41431012079 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 41431012080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431012081 putative active site [active] 41431012082 heme pocket [chemical binding]; other site 41431012083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 41431012084 dimer interface [polypeptide binding]; other site 41431012085 phosphorylation site [posttranslational modification] 41431012086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 41431012087 ATP binding site [chemical binding]; other site 41431012088 Mg2+ binding site [ion binding]; other site 41431012089 G-X-G motif; other site 41431012090 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 41431012091 ATP-NAD kinase; Region: NAD_kinase; pfam01513 41431012092 Putative cyclase; Region: Cyclase; pfam04199 41431012093 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 41431012094 Phosphoglycerate kinase; Region: PGK; pfam00162 41431012095 substrate binding site [chemical binding]; other site 41431012096 hinge regions; other site 41431012097 ADP binding site [chemical binding]; other site 41431012098 catalytic site [active] 41431012099 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 41431012100 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 41431012101 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 41431012102 RNA binding surface [nucleotide binding]; other site 41431012103 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 41431012104 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 41431012105 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 41431012106 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 41431012107 Substrate binding site; other site 41431012108 Mg++ binding site; other site 41431012109 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 41431012110 active site 41431012111 substrate binding site [chemical binding]; other site 41431012112 CoA binding site [chemical binding]; other site 41431012113 HflK protein; Region: hflK; TIGR01933 41431012114 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 41431012115 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 41431012116 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 41431012117 RNA binding surface [nucleotide binding]; other site 41431012118 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 41431012119 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 41431012120 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 41431012121 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 41431012122 Mg++ binding site [ion binding]; other site 41431012123 putative catalytic motif [active] 41431012124 putative substrate binding site [chemical binding]; other site 41431012125 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 41431012126 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 41431012127 active site 41431012128 Calx-beta domain; Region: Calx-beta; pfam03160 41431012129 Calx-beta domain; Region: Calx-beta; cl02522 41431012130 Calx-beta domain; Region: Calx-beta; cl02522 41431012131 Calx-beta domain; Region: Calx-beta; cl02522 41431012132 Calx-beta domain; Region: Calx-beta; cl02522 41431012133 Calx-beta domain; Region: Calx-beta; cl02522 41431012134 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 41431012135 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 41431012136 metal binding site [ion binding]; metal-binding site 41431012137 dimer interface [polypeptide binding]; other site 41431012138 Methyltransferase domain; Region: Methyltransf_23; pfam13489 41431012139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431012140 S-adenosylmethionine binding site [chemical binding]; other site 41431012141 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 41431012142 oligomerization interface [polypeptide binding]; other site 41431012143 active site 41431012144 metal binding site [ion binding]; metal-binding site 41431012145 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 41431012146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 41431012147 S-adenosylmethionine binding site [chemical binding]; other site 41431012148 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 41431012149 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 41431012150 RNA/DNA hybrid binding site [nucleotide binding]; other site 41431012151 active site 41431012152 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 41431012153 NMT1-like family; Region: NMT1_2; pfam13379 41431012154 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 41431012155 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 41431012156 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 41431012157 putative active site [active] 41431012158 putative substrate binding site [chemical binding]; other site 41431012159 putative cosubstrate binding site; other site 41431012160 catalytic site [active] 41431012161 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 41431012162 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 41431012163 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 41431012164 FeS/SAM binding site; other site 41431012165 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 41431012166 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 41431012167 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 41431012168 ATP binding site [chemical binding]; other site 41431012169 putative Mg++ binding site [ion binding]; other site 41431012170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 41431012171 nucleotide binding region [chemical binding]; other site 41431012172 ATP-binding site [chemical binding]; other site 41431012173 large tegument protein UL36; Provisional; Region: PHA03246 41431012174 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 41431012175 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 41431012176 Ligand binding site; other site 41431012177 Putative Catalytic site; other site 41431012178 DXD motif; other site 41431012179 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 41431012180 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 41431012181 Ligand binding site; other site 41431012182 Putative Catalytic site; other site 41431012183 DXD motif; other site 41431012184 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 41431012185 Bacterial sugar transferase; Region: Bac_transf; pfam02397 41431012186 argininosuccinate synthase; Provisional; Region: PRK13820 41431012187 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 41431012188 ANP binding site [chemical binding]; other site 41431012189 Substrate Binding Site II [chemical binding]; other site 41431012190 Substrate Binding Site I [chemical binding]; other site 41431012191 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 41431012192 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 41431012193 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 41431012194 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 41431012195 putative active site [active] 41431012196 GTPase CgtA; Reviewed; Region: obgE; PRK12299 41431012197 GTP1/OBG; Region: GTP1_OBG; pfam01018 41431012198 Obg GTPase; Region: Obg; cd01898 41431012199 G1 box; other site 41431012200 GTP/Mg2+ binding site [chemical binding]; other site 41431012201 Switch I region; other site 41431012202 G2 box; other site 41431012203 G3 box; other site 41431012204 Switch II region; other site 41431012205 G4 box; other site 41431012206 G5 box; other site 41431012207 tellurium resistance terB-like protein; Region: terB_like; cd07177 41431012208 metal binding site [ion binding]; metal-binding site 41431012209 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 41431012210 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 41431012211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 41431012212 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 41431012213 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 41431012214 Walker A/P-loop; other site 41431012215 ATP binding site [chemical binding]; other site 41431012216 Q-loop/lid; other site 41431012217 ABC transporter signature motif; other site 41431012218 Walker B; other site 41431012219 D-loop; other site 41431012220 H-loop/switch region; other site 41431012221 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 41431012222 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 41431012223 Walker A/P-loop; other site 41431012224 ATP binding site [chemical binding]; other site 41431012225 Q-loop/lid; other site 41431012226 ABC transporter signature motif; other site 41431012227 Walker B; other site 41431012228 D-loop; other site 41431012229 H-loop/switch region; other site 41431012230 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 41431012231 NMT1-like family; Region: NMT1_2; pfam13379 41431012232 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 41431012233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 41431012234 dimer interface [polypeptide binding]; other site 41431012235 conserved gate region; other site 41431012236 putative PBP binding loops; other site 41431012237 ABC-ATPase subunit interface; other site 41431012238 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 41431012239 NMT1-like family; Region: NMT1_2; pfam13379 41431012240 short chain dehydrogenase; Validated; Region: PRK08324 41431012241 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 41431012242 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 41431012243 putative NAD(P) binding site [chemical binding]; other site 41431012244 active site 41431012245 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 41431012246 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 41431012247 active site 41431012248 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 41431012249 Cadmium resistance transporter; Region: Cad; pfam03596 41431012250 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 41431012251 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 41431012252 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 41431012253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 41431012254 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 41431012255 putative dimerization interface [polypeptide binding]; other site 41431012256 Cadmium resistance transporter; Region: Cad; pfam03596 41431012257 cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779 41431012258 Domain of unknown function (DUF202); Region: DUF202; pfam02656 41431012259 PAS fold; Region: PAS; pfam00989 41431012260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431012261 putative active site [active] 41431012262 heme pocket [chemical binding]; other site 41431012263 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 41431012264 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 41431012265 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 41431012266 transmembrane helices; other site 41431012267 TrkA-C domain; Region: TrkA_C; pfam02080 41431012268 TrkA-C domain; Region: TrkA_C; pfam02080 41431012269 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 41431012270 Integral membrane protein TerC family; Region: TerC; cl10468 41431012271 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 41431012272 Cadmium resistance transporter; Region: Cad; pfam03596 41431012273 FOG: WD40 repeat [General function prediction only]; Region: COG2319 41431012274 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431012275 structural tetrad; other site 41431012276 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431012277 structural tetrad; other site 41431012278 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 41431012279 structural tetrad; other site 41431012280 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431012281 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 41431012282 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 41431012283 TrkA-N domain; Region: TrkA_N; pfam02254 41431012284 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 41431012285 TrkA-N domain; Region: TrkA_N; pfam02254 41431012286 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 41431012287 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 41431012288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 41431012289 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 41431012290 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 41431012291 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 41431012292 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 41431012293 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 41431012294 shikimate binding site; other site 41431012295 NAD(P) binding site [chemical binding]; other site 41431012296 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 41431012297 dihydroorotase; Provisional; Region: PRK07575 41431012298 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 41431012299 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 41431012300 active site 41431012301 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 41431012302 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 41431012303 Catalytic site [active] 41431012304 RNA polymerase sigma factor; Provisional; Region: PRK12518 41431012305 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 41431012306 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 41431012307 DNA binding residues [nucleotide binding] 41431012308 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 41431012309 dimer interface [polypeptide binding]; other site 41431012310 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 41431012311 putative hydrolase; Provisional; Region: PRK11460 41431012312 PAS domain S-box; Region: sensory_box; TIGR00229 41431012313 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431012314 putative active site [active] 41431012315 heme pocket [chemical binding]; other site 41431012316 PAS domain S-box; Region: sensory_box; TIGR00229 41431012317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431012318 putative active site [active] 41431012319 heme pocket [chemical binding]; other site 41431012320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431012321 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 41431012322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431012323 putative active site [active] 41431012324 heme pocket [chemical binding]; other site 41431012325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 41431012326 putative active site [active] 41431012327 heme pocket [chemical binding]; other site 41431012328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 41431012329 metal binding site [ion binding]; metal-binding site 41431012330 active site 41431012331 I-site; other site 41431012332 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 41431012333 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 41431012334 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 41431012335 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 41431012336 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 41431012337 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 41431012338 Uncharacterized conserved protein [Function unknown]; Region: COG2968 41431012339 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 41431012340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 41431012341 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 41431012342 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431012343 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 41431012344 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 41431012345 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 41431012346 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 41431012347 putative active site [active] 41431012348 putative metal binding site [ion binding]; other site 41431012349 Predicted integral membrane protein [Function unknown]; Region: COG0762 41431012350 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 41431012351 dimer interface [polypeptide binding]; other site 41431012352 catalytic triad [active] 41431012353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 41431012354 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 41431012355 Probable transposase; Region: OrfB_IS605; pfam01385 41431012356 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 41431012357 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 41431012358 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 41431012359 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 41431012360 Ligand binding site; other site 41431012361 Putative Catalytic site; other site 41431012362 DXD motif; other site 41431012363 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 41431012364 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 41431012365 Family of unknown function (DUF490); Region: DUF490; pfam04357 41431012366 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 41431012367 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 41431012368 substrate binding pocket [chemical binding]; other site 41431012369 membrane-bound complex binding site; other site 41431012370 hinge residues; other site 41431012371 GXWXG protein; Region: GXWXG; pfam14231 41431012372 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 41431012373 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 41431012374 Stage II sporulation protein; Region: SpoIID; pfam08486 41431012375 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 41431012376 active site 41431012377 catalytic triad [active] 41431012378 oxyanion hole [active] 41431012379 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 41431012380 active site 41431012381 catalytic residues [active] 41431012382 metal binding site [ion binding]; metal-binding site 41431012383 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 41431012384 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 41431012385 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 41431012386 RHS Repeat; Region: RHS_repeat; cl11982 41431012387 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 41431012388 RHS Repeat; Region: RHS_repeat; cl11982 41431012389 RHS Repeat; Region: RHS_repeat; pfam05593 41431012390 RHS Repeat; Region: RHS_repeat; pfam05593 41431012391 RHS Repeat; Region: RHS_repeat; cl11982 41431012392 RHS Repeat; Region: RHS_repeat; pfam05593 41431012393 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 41431012394 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 41431012395 active site 41431012396 Int/Topo IB signature motif; other site 41431012397 DNA binding site [nucleotide binding] 41431012398 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 41431012399 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 41431012400 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 41431012401 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 41431012402 active site 41431012403 metal binding site [ion binding]; metal-binding site