-- dump date 20140619_055252 -- class Genbank::misc_feature -- table misc_feature_note -- id note 56107000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 56107000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 56107000003 putative DNA binding surface [nucleotide binding]; other site 56107000004 dimer interface [polypeptide binding]; other site 56107000005 beta-clamp/clamp loader binding surface; other site 56107000006 beta-clamp/translesion DNA polymerase binding surface; other site 56107000007 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 56107000008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107000009 Walker A motif; other site 56107000010 ATP binding site [chemical binding]; other site 56107000011 Walker B motif; other site 56107000012 arginine finger; other site 56107000013 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 56107000014 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 56107000015 DNA polymerase type-B family; Region: POLBc; smart00486 56107000016 active site 56107000017 catalytic site [active] 56107000018 substrate binding site [chemical binding]; other site 56107000019 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 56107000020 active site 56107000021 metal-binding site 56107000022 Superfamily II helicase [General function prediction only]; Region: COG1204 56107000023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107000024 ATP binding site [chemical binding]; other site 56107000025 putative Mg++ binding site [ion binding]; other site 56107000026 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 56107000027 DNA polymerase III subunit delta; Validated; Region: PRK07452 56107000028 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 56107000029 DNA polymerase III subunit delta'; Validated; Region: PRK07399 56107000030 DNA polymerase III subunit delta'; Validated; Region: PRK08485 56107000031 50S ribosomal protein L20/unknown domain fusion protein; Provisional; Region: PRK14537 56107000032 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 56107000033 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 56107000034 dimer interface [polypeptide binding]; other site 56107000035 ssDNA binding site [nucleotide binding]; other site 56107000036 tetramer (dimer of dimers) interface [polypeptide binding]; other site 56107000037 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 56107000038 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107000039 P-loop; other site 56107000040 Magnesium ion binding site [ion binding]; other site 56107000041 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107000042 Magnesium ion binding site [ion binding]; other site 56107000043 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 56107000044 ParB-like nuclease domain; Region: ParBc; pfam02195 56107000045 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 56107000046 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 56107000047 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 56107000048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107000049 Walker A motif; other site 56107000050 ATP binding site [chemical binding]; other site 56107000051 Walker B motif; other site 56107000052 arginine finger; other site 56107000053 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 56107000054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107000055 S-adenosylmethionine binding site [chemical binding]; other site 56107000056 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 56107000057 DEAD-like helicases superfamily; Region: DEXDc; smart00487 56107000058 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 56107000059 helicase superfamily c-terminal domain; Region: HELICc; smart00490 56107000060 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 56107000061 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 56107000062 active site 56107000063 catalytic tetrad [active] 56107000064 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 56107000065 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 56107000066 putative NAD(P) binding site [chemical binding]; other site 56107000067 putative substrate binding site [chemical binding]; other site 56107000068 catalytic Zn binding site [ion binding]; other site 56107000069 structural Zn binding site [ion binding]; other site 56107000070 dimer interface [polypeptide binding]; other site 56107000071 short chain dehydrogenase; Provisional; Region: PRK06172 56107000072 classical (c) SDRs; Region: SDR_c; cd05233 56107000073 NAD(P) binding site [chemical binding]; other site 56107000074 active site 56107000075 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 56107000076 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 56107000077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 56107000078 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 56107000079 Mg binding site [ion binding]; other site 56107000080 nucleotide binding site [chemical binding]; other site 56107000081 putative protofilament interface [polypeptide binding]; other site 56107000082 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 56107000083 MarR family; Region: MarR_2; pfam12802 56107000084 replicative DNA helicase; Region: DnaB; TIGR00665 56107000085 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 56107000086 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 56107000087 Walker A motif; other site 56107000088 ATP binding site [chemical binding]; other site 56107000089 Walker B motif; other site 56107000090 DNA binding loops [nucleotide binding] 56107000091 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107000092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107000093 active site 56107000094 phosphorylation site [posttranslational modification] 56107000095 intermolecular recognition site; other site 56107000096 dimerization interface [polypeptide binding]; other site 56107000097 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107000098 DNA binding residues [nucleotide binding] 56107000099 dimerization interface [polypeptide binding]; other site 56107000100 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 56107000101 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107000102 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 56107000103 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 56107000104 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107000105 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 56107000106 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 56107000107 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107000108 Transposase [DNA replication, recombination, and repair]; Region: COG5433 56107000109 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 56107000110 S-layer homology domain; Region: SLH; pfam00395 56107000111 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 56107000112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 56107000113 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 56107000114 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 56107000115 metal-binding site [ion binding] 56107000116 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 56107000117 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 56107000118 metal-binding site [ion binding] 56107000119 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 56107000120 Soluble P-type ATPase [General function prediction only]; Region: COG4087 56107000121 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 56107000122 putative DNA binding site [nucleotide binding]; other site 56107000123 dimerization interface [polypeptide binding]; other site 56107000124 putative Zn2+ binding site [ion binding]; other site 56107000125 manganese transport protein MntH; Reviewed; Region: PRK00701 56107000126 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 56107000127 TPR repeat; Region: TPR_11; pfam13414 56107000128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107000129 binding surface 56107000130 Tetratricopeptide repeat; Region: TPR_16; pfam13432 56107000131 TPR motif; other site 56107000132 TPR repeat; Region: TPR_11; pfam13414 56107000133 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 56107000134 Protein export membrane protein; Region: SecD_SecF; cl14618 56107000135 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 56107000136 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 56107000137 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 56107000138 Sodium Bile acid symporter family; Region: SBF; cl17470 56107000139 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 56107000140 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 56107000141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 56107000142 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 56107000143 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 56107000144 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 56107000145 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107000146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107000147 active site 56107000148 phosphorylation site [posttranslational modification] 56107000149 intermolecular recognition site; other site 56107000150 dimerization interface [polypeptide binding]; other site 56107000151 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107000152 DNA binding site [nucleotide binding] 56107000153 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 56107000154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107000155 dimer interface [polypeptide binding]; other site 56107000156 phosphorylation site [posttranslational modification] 56107000157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107000158 ATP binding site [chemical binding]; other site 56107000159 Mg2+ binding site [ion binding]; other site 56107000160 G-X-G motif; other site 56107000161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 56107000162 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 56107000163 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 56107000164 cofactor binding site; other site 56107000165 DNA binding site [nucleotide binding] 56107000166 substrate interaction site [chemical binding]; other site 56107000167 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 56107000168 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 56107000169 active site 56107000170 GIY-YIG motif/motif A; other site 56107000171 catalytic site [active] 56107000172 metal binding site [ion binding]; metal-binding site 56107000173 Domain of unknown function (DUF955); Region: DUF955; pfam06114 56107000174 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 56107000175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107000176 salt bridge; other site 56107000177 non-specific DNA binding site [nucleotide binding]; other site 56107000178 sequence-specific DNA binding site [nucleotide binding]; other site 56107000179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 56107000180 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 56107000181 ATP binding site [chemical binding]; other site 56107000182 substrate interface [chemical binding]; other site 56107000183 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 56107000184 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 56107000185 active site 56107000186 NTP binding site [chemical binding]; other site 56107000187 metal binding triad [ion binding]; metal-binding site 56107000188 AIPR protein; Region: AIPR; pfam10592 56107000189 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 56107000190 active site 56107000191 Int/Topo IB signature motif; other site 56107000192 DNA binding site [nucleotide binding] 56107000193 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 56107000194 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 56107000195 putative active site [active] 56107000196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107000197 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 56107000198 Walker A motif; other site 56107000199 ATP binding site [chemical binding]; other site 56107000200 Walker B motif; other site 56107000201 arginine finger; other site 56107000202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107000203 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 56107000204 Coenzyme A binding pocket [chemical binding]; other site 56107000205 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 56107000206 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 56107000207 DNA binding site [nucleotide binding] 56107000208 AAA domain; Region: AAA_30; pfam13604 56107000209 Family description; Region: UvrD_C_2; pfam13538 56107000210 AAA-like domain; Region: AAA_10; pfam12846 56107000211 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 56107000212 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 56107000213 Dehydratase family; Region: ILVD_EDD; cl00340 56107000214 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 56107000215 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 56107000216 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 56107000217 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 56107000218 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107000219 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 56107000220 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701 56107000221 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701 56107000222 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 56107000223 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 56107000224 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 56107000225 PRTRC system protein A; Region: PRTRC_A; TIGR03735 56107000226 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 56107000227 ATP binding site [chemical binding]; other site 56107000228 substrate interface [chemical binding]; other site 56107000229 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 56107000230 DnaA N-terminal domain; Region: DnaA_N; pfam11638 56107000231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107000232 Walker A motif; other site 56107000233 ATP binding site [chemical binding]; other site 56107000234 Walker B motif; other site 56107000235 arginine finger; other site 56107000236 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 56107000237 DnaA box-binding interface [nucleotide binding]; other site 56107000238 DNA polymerase III subunit beta; Validated; Region: PRK05643 56107000239 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 56107000240 putative DNA binding surface [nucleotide binding]; other site 56107000241 dimer interface [polypeptide binding]; other site 56107000242 beta-clamp/clamp loader binding surface; other site 56107000243 beta-clamp/translesion DNA polymerase binding surface; other site 56107000244 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107000245 GAF domain; Region: GAF; pfam01590 56107000246 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107000247 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107000248 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107000249 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107000250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107000251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107000252 dimer interface [polypeptide binding]; other site 56107000253 phosphorylation site [posttranslational modification] 56107000254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107000255 ATP binding site [chemical binding]; other site 56107000256 Mg2+ binding site [ion binding]; other site 56107000257 G-X-G motif; other site 56107000258 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 56107000259 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 56107000260 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 56107000261 acyltransferase PapA5; Provisional; Region: PRK09294 56107000262 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 56107000263 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 56107000264 NADP binding site [chemical binding]; other site 56107000265 substrate binding site [chemical binding]; other site 56107000266 active site 56107000267 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 56107000268 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 56107000269 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 56107000270 hydrophobic ligand binding site; other site 56107000271 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 56107000272 hydrophobic ligand binding site; other site 56107000273 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 56107000274 putative hydrophobic ligand binding site [chemical binding]; other site 56107000275 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 56107000276 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 56107000277 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 56107000278 acyl-activating enzyme (AAE) consensus motif; other site 56107000279 acyl-activating enzyme (AAE) consensus motif; other site 56107000280 AMP binding site [chemical binding]; other site 56107000281 active site 56107000282 CoA binding site [chemical binding]; other site 56107000283 Major Facilitator Superfamily; Region: MFS_1; pfam07690 56107000284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107000285 putative substrate translocation pore; other site 56107000286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107000287 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 56107000288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107000289 S-adenosylmethionine binding site [chemical binding]; other site 56107000290 hypothetical protein; Provisional; Region: PRK06185 56107000291 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 56107000292 hypothetical protein; Provisional; Region: PRK06185 56107000293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107000294 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 56107000295 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 56107000296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107000297 NAD(P) binding site [chemical binding]; other site 56107000298 active site 56107000299 Putative cyclase; Region: Cyclase; pfam04199 56107000300 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107000301 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 56107000302 active site 56107000303 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107000304 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107000305 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107000306 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 56107000307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107000308 non-specific DNA binding site [nucleotide binding]; other site 56107000309 salt bridge; other site 56107000310 sequence-specific DNA binding site [nucleotide binding]; other site 56107000311 PBP superfamily domain; Region: PBP_like; pfam12727 56107000312 nitrogenase reductase; Reviewed; Region: PRK13236 56107000313 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 56107000314 Nucleotide-binding sites [chemical binding]; other site 56107000315 Walker A motif; other site 56107000316 Switch I region of nucleotide binding site; other site 56107000317 Fe4S4 binding sites [ion binding]; other site 56107000318 Switch II region of nucleotide binding site; other site 56107000319 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 56107000320 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 56107000321 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 56107000322 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 56107000323 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 56107000324 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 56107000325 P loop; other site 56107000326 Nucleotide binding site [chemical binding]; other site 56107000327 DTAP/Switch II; other site 56107000328 Switch I; other site 56107000329 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 56107000330 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 56107000331 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 56107000332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 56107000333 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107000334 HSP70 interaction site [polypeptide binding]; other site 56107000335 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 56107000336 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 56107000337 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 56107000338 tetramer interface [polypeptide binding]; other site 56107000339 TPP-binding site [chemical binding]; other site 56107000340 heterodimer interface [polypeptide binding]; other site 56107000341 phosphorylation loop region [posttranslational modification] 56107000342 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 56107000343 active site 56107000344 catalytic residues [active] 56107000345 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 56107000346 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 56107000347 tetramer interface [polypeptide binding]; other site 56107000348 heme binding pocket [chemical binding]; other site 56107000349 NADPH binding site [chemical binding]; other site 56107000350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 56107000351 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 56107000352 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 56107000353 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 56107000354 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 56107000355 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 56107000356 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 56107000357 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 56107000358 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 56107000359 TPR repeat; Region: TPR_11; pfam13414 56107000360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107000361 binding surface 56107000362 TPR motif; other site 56107000363 TPR repeat; Region: TPR_11; pfam13414 56107000364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107000365 binding surface 56107000366 TPR repeat; Region: TPR_11; pfam13414 56107000367 TPR motif; other site 56107000368 TPR repeat; Region: TPR_11; pfam13414 56107000369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107000370 binding surface 56107000371 TPR repeat; Region: TPR_11; pfam13414 56107000372 TPR motif; other site 56107000373 TPR repeat; Region: TPR_11; pfam13414 56107000374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107000375 binding surface 56107000376 TPR motif; other site 56107000377 TPR repeat; Region: TPR_11; pfam13414 56107000378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107000379 binding surface 56107000380 TPR motif; other site 56107000381 TPR repeat; Region: TPR_11; pfam13414 56107000382 TPR repeat; Region: TPR_11; pfam13414 56107000383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107000384 binding surface 56107000385 TPR motif; other site 56107000386 TPR repeat; Region: TPR_11; pfam13414 56107000387 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 56107000388 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 56107000389 putative ligand binding site [chemical binding]; other site 56107000390 putative NAD binding site [chemical binding]; other site 56107000391 catalytic site [active] 56107000392 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 56107000393 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 56107000394 active site 56107000395 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 56107000396 DNA binding site [nucleotide binding] 56107000397 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 56107000398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107000399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107000400 active site 56107000401 phosphorylation site [posttranslational modification] 56107000402 intermolecular recognition site; other site 56107000403 dimerization interface [polypeptide binding]; other site 56107000404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107000405 DNA binding site [nucleotide binding] 56107000406 CHASE3 domain; Region: CHASE3; pfam05227 56107000407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107000408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107000409 dimer interface [polypeptide binding]; other site 56107000410 phosphorylation site [posttranslational modification] 56107000411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107000412 ATP binding site [chemical binding]; other site 56107000413 G-X-G motif; other site 56107000414 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 56107000415 Double zinc ribbon; Region: DZR; pfam12773 56107000416 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 56107000417 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 56107000418 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 56107000419 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 56107000420 phosphopeptide binding site; other site 56107000421 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 56107000422 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 56107000423 putative active site [active] 56107000424 Permease; Region: Permease; cl00510 56107000425 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 56107000426 ribonuclease PH; Reviewed; Region: rph; PRK00173 56107000427 Ribonuclease PH; Region: RNase_PH_bact; cd11362 56107000428 hexamer interface [polypeptide binding]; other site 56107000429 active site 56107000430 adenylate kinase; Provisional; Region: adk; PRK02496 56107000431 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 56107000432 AMP-binding site [chemical binding]; other site 56107000433 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 56107000434 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 56107000435 cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414 56107000436 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 56107000437 trimer interface [polypeptide binding]; other site 56107000438 active site 56107000439 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 56107000440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107000441 Walker A motif; other site 56107000442 ATP binding site [chemical binding]; other site 56107000443 Walker B motif; other site 56107000444 arginine finger; other site 56107000445 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107000446 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107000447 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 56107000448 structural tetrad; other site 56107000449 Tetrahydromethanopterin S-methyltransferase, subunit A; Region: MtrA; cl04449 56107000450 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 56107000451 dimerization interface [polypeptide binding]; other site 56107000452 active site 56107000453 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 56107000454 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107000455 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107000456 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 56107000457 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 56107000458 hinge; other site 56107000459 active site 56107000460 BON domain; Region: BON; cl02771 56107000461 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 56107000462 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 56107000463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107000464 binding surface 56107000465 TPR motif; other site 56107000466 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 56107000467 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 56107000468 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 56107000469 putative C-terminal domain interface [polypeptide binding]; other site 56107000470 putative GSH binding site (G-site) [chemical binding]; other site 56107000471 putative dimer interface [polypeptide binding]; other site 56107000472 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 56107000473 N-terminal domain interface [polypeptide binding]; other site 56107000474 dimer interface [polypeptide binding]; other site 56107000475 substrate binding pocket (H-site) [chemical binding]; other site 56107000476 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 56107000477 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 56107000478 Predicted membrane protein [Function unknown]; Region: COG4244 56107000479 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 56107000480 Hemerythrin-like domain; Region: Hr-like; cd12108 56107000481 Fe binding site [ion binding]; other site 56107000482 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 56107000483 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 56107000484 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 56107000485 metal binding site [ion binding]; metal-binding site 56107000486 dimer interface [polypeptide binding]; other site 56107000487 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107000488 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107000489 active site 56107000490 ATP binding site [chemical binding]; other site 56107000491 substrate binding site [chemical binding]; other site 56107000492 activation loop (A-loop); other site 56107000493 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 56107000494 dimerization interface [polypeptide binding]; other site 56107000495 putative Zn2+ binding site [ion binding]; other site 56107000496 putative DNA binding site [nucleotide binding]; other site 56107000497 ATP-grasp domain; Region: ATP-grasp_4; cl17255 56107000498 short chain dehydrogenase; Provisional; Region: PRK06701 56107000499 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 56107000500 NAD binding site [chemical binding]; other site 56107000501 metal binding site [ion binding]; metal-binding site 56107000502 active site 56107000503 mercuric reductase; Validated; Region: PRK06370 56107000504 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 56107000505 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 56107000506 Uncharacterized conserved protein [Function unknown]; Region: COG0398 56107000507 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 56107000508 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 56107000509 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 56107000510 Probable Catalytic site; other site 56107000511 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 56107000512 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 56107000513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107000514 homodimer interface [polypeptide binding]; other site 56107000515 catalytic residue [active] 56107000516 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107000517 putative active site [active] 56107000518 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107000519 putative active site [active] 56107000520 RloB-like protein; Region: RloB; pfam13707 56107000521 Predicted ATPases [General function prediction only]; Region: COG1106 56107000522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107000523 ABC transporter signature motif; other site 56107000524 Walker B; other site 56107000525 D-loop; other site 56107000526 H-loop/switch region; other site 56107000527 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 56107000528 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 56107000529 putative Cl- selectivity filter; other site 56107000530 putative pore gating glutamate residue; other site 56107000531 heat shock protein HtpX; Provisional; Region: PRK03982 56107000532 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107000533 putative active site [active] 56107000534 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107000535 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107000536 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107000537 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107000538 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107000539 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107000540 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 56107000541 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 56107000542 dimer interface [polypeptide binding]; other site 56107000543 anticodon binding site; other site 56107000544 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 56107000545 homodimer interface [polypeptide binding]; other site 56107000546 motif 1; other site 56107000547 active site 56107000548 motif 2; other site 56107000549 GAD domain; Region: GAD; pfam02938 56107000550 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 56107000551 motif 3; other site 56107000552 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107000553 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 56107000554 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 56107000555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107000556 TPR motif; other site 56107000557 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107000558 binding surface 56107000559 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107000560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107000561 binding surface 56107000562 TPR motif; other site 56107000563 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107000564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107000565 binding surface 56107000566 TPR motif; other site 56107000567 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107000568 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107000569 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 56107000570 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 56107000571 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 56107000572 catalytic triad [active] 56107000573 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 56107000574 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 56107000575 active site 56107000576 catalytic triad [active] 56107000577 oxyanion hole [active] 56107000578 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 56107000579 DNA protecting protein DprA; Region: dprA; TIGR00732 56107000580 PAS domain S-box; Region: sensory_box; TIGR00229 56107000581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107000582 putative active site [active] 56107000583 heme pocket [chemical binding]; other site 56107000584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107000585 putative active site [active] 56107000586 heme pocket [chemical binding]; other site 56107000587 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 56107000588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107000589 putative active site [active] 56107000590 heme pocket [chemical binding]; other site 56107000591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107000592 dimer interface [polypeptide binding]; other site 56107000593 phosphorylation site [posttranslational modification] 56107000594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107000595 ATP binding site [chemical binding]; other site 56107000596 Mg2+ binding site [ion binding]; other site 56107000597 G-X-G motif; other site 56107000598 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 56107000599 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 56107000600 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 56107000601 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 56107000602 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 56107000603 active site 56107000604 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107000605 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107000606 active site 56107000607 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 56107000608 putative active site [active] 56107000609 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 56107000610 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 56107000611 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 56107000612 ATP binding site [chemical binding]; other site 56107000613 putative Mg++ binding site [ion binding]; other site 56107000614 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 56107000615 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 56107000616 Dihaem cytochrome c; Region: DHC; pfam09626 56107000617 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107000618 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 56107000619 VirC1 protein; Region: VirC1; cl17401 56107000620 MoxR-like ATPases [General function prediction only]; Region: COG0714 56107000621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107000622 ATP binding site [chemical binding]; other site 56107000623 Walker A motif; other site 56107000624 Walker B motif; other site 56107000625 arginine finger; other site 56107000626 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 56107000627 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 56107000628 active site 56107000629 Riboflavin kinase; Region: Flavokinase; pfam01687 56107000630 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 56107000631 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 56107000632 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 56107000633 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 56107000634 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 56107000635 dimer interface [polypeptide binding]; other site 56107000636 motif 1; other site 56107000637 active site 56107000638 motif 2; other site 56107000639 motif 3; other site 56107000640 AAA domain; Region: AAA_17; pfam13207 56107000641 AAA domain; Region: AAA_33; pfam13671 56107000642 Uncharacterized conserved protein [Function unknown]; Region: COG4278 56107000643 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 56107000644 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107000645 ATP binding site [chemical binding]; other site 56107000646 putative Mg++ binding site [ion binding]; other site 56107000647 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107000648 nucleotide binding region [chemical binding]; other site 56107000649 ATP-binding site [chemical binding]; other site 56107000650 HEAT repeats; Region: HEAT_2; pfam13646 56107000651 HEAT repeats; Region: HEAT_2; pfam13646 56107000652 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 56107000653 2-isopropylmalate synthase; Validated; Region: PRK00915 56107000654 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 56107000655 active site 56107000656 catalytic residues [active] 56107000657 metal binding site [ion binding]; metal-binding site 56107000658 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 56107000659 Uncharacterized conserved protein [Function unknown]; Region: COG1432 56107000660 LabA_like proteins; Region: LabA; cd10911 56107000661 putative metal binding site [ion binding]; other site 56107000662 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 56107000663 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 56107000664 Protein kinase domain; Region: Pkinase; pfam00069 56107000665 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107000666 active site 56107000667 ATP binding site [chemical binding]; other site 56107000668 substrate binding site [chemical binding]; other site 56107000669 activation loop (A-loop); other site 56107000670 AAA ATPase domain; Region: AAA_16; pfam13191 56107000671 XisI protein; Region: XisI; pfam08869 56107000672 XisH protein; Region: XisH; pfam08814 56107000673 TROVE domain; Region: TROVE; pfam05731 56107000674 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 56107000675 metal ion-dependent adhesion site (MIDAS); other site 56107000676 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 56107000677 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 56107000678 quinone interaction residues [chemical binding]; other site 56107000679 active site 56107000680 catalytic residues [active] 56107000681 FMN binding site [chemical binding]; other site 56107000682 substrate binding site [chemical binding]; other site 56107000683 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107000684 GAF domain; Region: GAF; pfam01590 56107000685 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107000686 GAF domain; Region: GAF; pfam01590 56107000687 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 56107000688 ATP binding site [chemical binding]; other site 56107000689 Mg2+ binding site [ion binding]; other site 56107000690 G-X-G motif; other site 56107000691 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 56107000692 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 56107000693 active site 56107000694 dimer interface [polypeptide binding]; other site 56107000695 catalytic nucleophile [active] 56107000696 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107000697 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107000698 putative active site [active] 56107000699 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 56107000700 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 56107000701 Substrate binding site; other site 56107000702 Mg++ binding site; other site 56107000703 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 56107000704 active site 56107000705 substrate binding site [chemical binding]; other site 56107000706 CoA binding site [chemical binding]; other site 56107000707 Uncharacterized conserved protein [Function unknown]; Region: COG4121 56107000708 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 56107000709 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 56107000710 active site residue [active] 56107000711 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 56107000712 active site residue [active] 56107000713 FecR protein; Region: FecR; pfam04773 56107000714 glutathione reductase; Validated; Region: PRK06116 56107000715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 56107000716 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 56107000717 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 56107000718 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 56107000719 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 56107000720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 56107000721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107000722 homodimer interface [polypeptide binding]; other site 56107000723 catalytic residue [active] 56107000724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107000725 Coenzyme A binding pocket [chemical binding]; other site 56107000726 Response regulator receiver domain; Region: Response_reg; pfam00072 56107000727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107000728 active site 56107000729 phosphorylation site [posttranslational modification] 56107000730 intermolecular recognition site; other site 56107000731 dimerization interface [polypeptide binding]; other site 56107000732 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107000733 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107000734 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107000735 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107000736 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107000737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107000738 dimer interface [polypeptide binding]; other site 56107000739 phosphorylation site [posttranslational modification] 56107000740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107000741 ATP binding site [chemical binding]; other site 56107000742 Mg2+ binding site [ion binding]; other site 56107000743 G-X-G motif; other site 56107000744 Response regulator receiver domain; Region: Response_reg; pfam00072 56107000745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107000746 active site 56107000747 phosphorylation site [posttranslational modification] 56107000748 intermolecular recognition site; other site 56107000749 dimerization interface [polypeptide binding]; other site 56107000750 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 56107000751 cyclase homology domain; Region: CHD; cd07302 56107000752 nucleotidyl binding site; other site 56107000753 metal binding site [ion binding]; metal-binding site 56107000754 dimer interface [polypeptide binding]; other site 56107000755 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 56107000756 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 56107000757 Walker A/P-loop; other site 56107000758 ATP binding site [chemical binding]; other site 56107000759 Q-loop/lid; other site 56107000760 ABC transporter signature motif; other site 56107000761 Walker B; other site 56107000762 D-loop; other site 56107000763 H-loop/switch region; other site 56107000764 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 56107000765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107000766 dimer interface [polypeptide binding]; other site 56107000767 conserved gate region; other site 56107000768 putative PBP binding loops; other site 56107000769 ABC-ATPase subunit interface; other site 56107000770 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 56107000771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107000772 dimer interface [polypeptide binding]; other site 56107000773 conserved gate region; other site 56107000774 putative PBP binding loops; other site 56107000775 ABC-ATPase subunit interface; other site 56107000776 PBP superfamily domain; Region: PBP_like_2; cl17296 56107000777 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 56107000778 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 56107000779 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 56107000780 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 56107000781 phosphopeptide binding site; other site 56107000782 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 56107000783 Transglycosylase; Region: Transgly; pfam00912 56107000784 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 56107000785 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 56107000786 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 56107000787 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 56107000788 active site 56107000789 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 56107000790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107000791 dimer interface [polypeptide binding]; other site 56107000792 conserved gate region; other site 56107000793 putative PBP binding loops; other site 56107000794 ABC-ATPase subunit interface; other site 56107000795 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107000796 putative active site [active] 56107000797 amidophosphoribosyltransferase; Provisional; Region: PRK07349 56107000798 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 56107000799 active site 56107000800 tetramer interface [polypeptide binding]; other site 56107000801 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 56107000802 active site 56107000803 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 56107000804 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 56107000805 dimerization interface [polypeptide binding]; other site 56107000806 ATP binding site [chemical binding]; other site 56107000807 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 56107000808 dimerization interface [polypeptide binding]; other site 56107000809 ATP binding site [chemical binding]; other site 56107000810 Phycobilisome protein; Region: Phycobilisome; cl08227 56107000811 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 56107000812 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 56107000813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107000814 S-adenosylmethionine binding site [chemical binding]; other site 56107000815 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 56107000816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 56107000817 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 56107000818 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 56107000819 putative dimer interface [polypeptide binding]; other site 56107000820 putative anticodon binding site; other site 56107000821 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 56107000822 homodimer interface [polypeptide binding]; other site 56107000823 motif 1; other site 56107000824 motif 2; other site 56107000825 active site 56107000826 motif 3; other site 56107000827 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107000828 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107000829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107000830 active site 56107000831 phosphorylation site [posttranslational modification] 56107000832 intermolecular recognition site; other site 56107000833 dimerization interface [polypeptide binding]; other site 56107000834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107000835 DNA binding residues [nucleotide binding] 56107000836 dimerization interface [polypeptide binding]; other site 56107000837 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 56107000838 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 56107000839 oligomerisation interface [polypeptide binding]; other site 56107000840 mobile loop; other site 56107000841 roof hairpin; other site 56107000842 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 56107000843 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 56107000844 ring oligomerisation interface [polypeptide binding]; other site 56107000845 ATP/Mg binding site [chemical binding]; other site 56107000846 stacking interactions; other site 56107000847 hinge regions; other site 56107000848 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107000849 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 56107000850 YcfA-like protein; Region: YcfA; pfam07927 56107000851 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 56107000852 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 56107000853 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107000854 P-loop; other site 56107000855 Magnesium ion binding site [ion binding]; other site 56107000856 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107000857 Magnesium ion binding site [ion binding]; other site 56107000858 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 56107000859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107000860 FeS/SAM binding site; other site 56107000861 Response regulator receiver domain; Region: Response_reg; pfam00072 56107000862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107000863 active site 56107000864 phosphorylation site [posttranslational modification] 56107000865 intermolecular recognition site; other site 56107000866 dimerization interface [polypeptide binding]; other site 56107000867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107000868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107000869 dimer interface [polypeptide binding]; other site 56107000870 phosphorylation site [posttranslational modification] 56107000871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107000872 ATP binding site [chemical binding]; other site 56107000873 Mg2+ binding site [ion binding]; other site 56107000874 G-X-G motif; other site 56107000875 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 56107000876 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 56107000877 NAD(P) binding site [chemical binding]; other site 56107000878 catalytic residues [active] 56107000879 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 56107000880 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 56107000881 Moco binding site; other site 56107000882 metal coordination site [ion binding]; other site 56107000883 ribosomal protein L32; Validated; Region: rpl32; CHL00152 56107000884 Caspase domain; Region: Peptidase_C14; pfam00656 56107000885 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 56107000886 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 56107000887 transmembrane helices; other site 56107000888 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 56107000889 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 56107000890 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 56107000891 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 56107000892 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 56107000893 dihydrodipicolinate synthase; Region: dapA; TIGR00674 56107000894 dimer interface [polypeptide binding]; other site 56107000895 active site 56107000896 catalytic residue [active] 56107000897 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 56107000898 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 56107000899 trigger factor; Provisional; Region: tig; PRK01490 56107000900 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 56107000901 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 56107000902 Clp protease; Region: CLP_protease; pfam00574 56107000903 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 56107000904 oligomer interface [polypeptide binding]; other site 56107000905 active site residues [active] 56107000906 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 56107000907 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 56107000908 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 56107000909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107000910 Walker A motif; other site 56107000911 ATP binding site [chemical binding]; other site 56107000912 Walker B motif; other site 56107000913 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 56107000914 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 56107000915 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 56107000916 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 56107000917 dimer interface [polypeptide binding]; other site 56107000918 FMN binding site [chemical binding]; other site 56107000919 Predicted transcriptional regulators [Transcription]; Region: COG1725 56107000920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 56107000921 DNA-binding site [nucleotide binding]; DNA binding site 56107000922 Dienelactone hydrolase family; Region: DLH; pfam01738 56107000923 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 56107000924 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 56107000925 RNA binding site [nucleotide binding]; other site 56107000926 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 56107000927 RNA binding site [nucleotide binding]; other site 56107000928 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 56107000929 RNA binding site [nucleotide binding]; other site 56107000930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107000931 non-specific DNA binding site [nucleotide binding]; other site 56107000932 salt bridge; other site 56107000933 sequence-specific DNA binding site [nucleotide binding]; other site 56107000934 DDE superfamily endonuclease; Region: DDE_5; cl17874 56107000935 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107000936 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 56107000937 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 56107000938 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 56107000939 dimerization interface [polypeptide binding]; other site 56107000940 active site 56107000941 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 56107000942 ribosomal protein L21; Region: rpl21; CHL00075 56107000943 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 56107000944 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 56107000945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 56107000946 Walker A motif; other site 56107000947 ATP binding site [chemical binding]; other site 56107000948 acetolactate synthase; Reviewed; Region: PRK08322 56107000949 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 56107000950 PYR/PP interface [polypeptide binding]; other site 56107000951 dimer interface [polypeptide binding]; other site 56107000952 TPP binding site [chemical binding]; other site 56107000953 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 56107000954 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 56107000955 TPP-binding site [chemical binding]; other site 56107000956 dimer interface [polypeptide binding]; other site 56107000957 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 56107000958 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 56107000959 NAD(P) binding site [chemical binding]; other site 56107000960 catalytic residues [active] 56107000961 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 56107000962 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 56107000963 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 56107000964 phosphopeptide binding site; other site 56107000965 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107000966 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107000967 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 56107000968 cyclase homology domain; Region: CHD; cd07302 56107000969 nucleotidyl binding site; other site 56107000970 metal binding site [ion binding]; metal-binding site 56107000971 dimer interface [polypeptide binding]; other site 56107000972 Protein kinase domain; Region: Pkinase; pfam00069 56107000973 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107000974 active site 56107000975 ATP binding site [chemical binding]; other site 56107000976 substrate binding site [chemical binding]; other site 56107000977 activation loop (A-loop); other site 56107000978 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 56107000979 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 56107000980 GTP/Mg2+ binding site [chemical binding]; other site 56107000981 G4 box; other site 56107000982 G5 box; other site 56107000983 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 56107000984 G1 box; other site 56107000985 G1 box; other site 56107000986 GTP/Mg2+ binding site [chemical binding]; other site 56107000987 Switch I region; other site 56107000988 G2 box; other site 56107000989 G2 box; other site 56107000990 Switch I region; other site 56107000991 G3 box; other site 56107000992 G3 box; other site 56107000993 Switch II region; other site 56107000994 Switch II region; other site 56107000995 G4 box; other site 56107000996 G5 box; other site 56107000997 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 56107000998 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 56107000999 active site 56107001000 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107001001 putative active site [active] 56107001002 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 56107001003 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 56107001004 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 56107001005 putative active site; other site 56107001006 catalytic residue [active] 56107001007 aspartate aminotransferase; Provisional; Region: PRK05764 56107001008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 56107001009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107001010 homodimer interface [polypeptide binding]; other site 56107001011 catalytic residue [active] 56107001012 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 56107001013 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107001014 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 56107001015 putative metal binding site; other site 56107001016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107001017 TPR motif; other site 56107001018 binding surface 56107001019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107001020 binding surface 56107001021 TPR repeat; Region: TPR_11; pfam13414 56107001022 TPR motif; other site 56107001023 TPR repeat; Region: TPR_11; pfam13414 56107001024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107001025 binding surface 56107001026 TPR motif; other site 56107001027 TPR repeat; Region: TPR_11; pfam13414 56107001028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107001029 binding surface 56107001030 TPR motif; other site 56107001031 TPR repeat; Region: TPR_11; pfam13414 56107001032 TPR repeat; Region: TPR_11; pfam13414 56107001033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107001034 binding surface 56107001035 TPR motif; other site 56107001036 TPR repeat; Region: TPR_11; pfam13414 56107001037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107001038 binding surface 56107001039 TPR motif; other site 56107001040 TPR repeat; Region: TPR_11; pfam13414 56107001041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107001042 binding surface 56107001043 TPR motif; other site 56107001044 TPR repeat; Region: TPR_11; pfam13414 56107001045 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107001046 putative active site [active] 56107001047 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 56107001048 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 56107001049 putative NAD(P) binding site [chemical binding]; other site 56107001050 active site 56107001051 proton extrusion protein PcxA; Provisional; Region: PRK02507 56107001052 MltA specific insert domain; Region: MltA; cl08398 56107001053 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 56107001054 methionine sulfoxide reductase B; Provisional; Region: PRK00222 56107001055 SelR domain; Region: SelR; pfam01641 56107001056 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 56107001057 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 56107001058 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 56107001059 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107001060 substrate binding pocket [chemical binding]; other site 56107001061 membrane-bound complex binding site; other site 56107001062 hinge residues; other site 56107001063 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 56107001064 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107001065 substrate binding pocket [chemical binding]; other site 56107001066 membrane-bound complex binding site; other site 56107001067 hinge residues; other site 56107001068 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 56107001069 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 56107001070 active site 56107001071 catalytic residues [active] 56107001072 metal binding site [ion binding]; metal-binding site 56107001073 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 56107001074 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 56107001075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107001076 Major Facilitator Superfamily; Region: MFS_1; pfam07690 56107001077 putative substrate translocation pore; other site 56107001078 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 56107001079 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 56107001080 putative ligand binding site [chemical binding]; other site 56107001081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107001082 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107001083 dimerization interface [polypeptide binding]; other site 56107001084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107001085 dimer interface [polypeptide binding]; other site 56107001086 phosphorylation site [posttranslational modification] 56107001087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107001088 ATP binding site [chemical binding]; other site 56107001089 Mg2+ binding site [ion binding]; other site 56107001090 G-X-G motif; other site 56107001091 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 56107001092 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 56107001093 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 56107001094 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 56107001095 Uncharacterized conserved protein (DUF2359); Region: DUF2359; pfam10151 56107001096 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 56107001097 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107001098 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107001099 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107001100 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107001101 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107001102 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107001103 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107001104 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107001105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107001106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107001107 dimer interface [polypeptide binding]; other site 56107001108 phosphorylation site [posttranslational modification] 56107001109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107001110 ATP binding site [chemical binding]; other site 56107001111 Mg2+ binding site [ion binding]; other site 56107001112 G-X-G motif; other site 56107001113 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 56107001114 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 56107001115 substrate binding pocket [chemical binding]; other site 56107001116 active site 56107001117 iron coordination sites [ion binding]; other site 56107001118 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 56107001119 EamA-like transporter family; Region: EamA; pfam00892 56107001120 EamA-like transporter family; Region: EamA; pfam00892 56107001121 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 56107001122 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 56107001123 putative active site [active] 56107001124 putative metal binding residues [ion binding]; other site 56107001125 signature motif; other site 56107001126 putative dimer interface [polypeptide binding]; other site 56107001127 putative phosphate binding site [ion binding]; other site 56107001128 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 56107001129 active site 56107001130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 56107001131 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107001132 active site 56107001133 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107001134 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107001135 active site 56107001136 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107001137 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107001138 active site 56107001139 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 56107001140 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 56107001141 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 56107001142 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 56107001143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107001144 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 56107001145 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 56107001146 acyl-activating enzyme (AAE) consensus motif; other site 56107001147 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107001148 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107001149 active site 56107001150 ATP binding site [chemical binding]; other site 56107001151 substrate binding site [chemical binding]; other site 56107001152 activation loop (A-loop); other site 56107001153 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 56107001154 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107001155 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107001156 active site 56107001157 ATP binding site [chemical binding]; other site 56107001158 substrate binding site [chemical binding]; other site 56107001159 activation loop (A-loop); other site 56107001160 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107001161 putative active site [active] 56107001162 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 56107001163 Phosphoglycerate kinase; Region: PGK; pfam00162 56107001164 substrate binding site [chemical binding]; other site 56107001165 hinge regions; other site 56107001166 ADP binding site [chemical binding]; other site 56107001167 catalytic site [active] 56107001168 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 56107001169 Ligand Binding Site [chemical binding]; other site 56107001170 Transposase IS200 like; Region: Y1_Tnp; cl00848 56107001171 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 56107001172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107001173 FeS/SAM binding site; other site 56107001174 HemN C-terminal domain; Region: HemN_C; pfam06969 56107001175 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 56107001176 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 56107001177 putative active site [active] 56107001178 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 56107001179 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 56107001180 putative metal binding site [ion binding]; other site 56107001181 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 56107001182 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 56107001183 metal ion-dependent adhesion site (MIDAS); other site 56107001184 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 56107001185 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 56107001186 metal ion-dependent adhesion site (MIDAS); other site 56107001187 Uncharacterized protein family (UPF0146); Region: UPF0146; cl00552 56107001188 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 56107001189 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 56107001190 oligomer interface [polypeptide binding]; other site 56107001191 active site residues [active] 56107001192 Clp protease; Region: CLP_protease; pfam00574 56107001193 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 56107001194 oligomer interface [polypeptide binding]; other site 56107001195 active site residues [active] 56107001196 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107001197 HSP70 interaction site [polypeptide binding]; other site 56107001198 Tetratricopeptide repeat; Region: TPR_16; pfam13432 56107001199 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 56107001200 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 56107001201 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 56107001202 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 56107001203 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 56107001204 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 56107001205 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 56107001206 hinge; other site 56107001207 active site 56107001208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107001209 non-specific DNA binding site [nucleotide binding]; other site 56107001210 salt bridge; other site 56107001211 sequence-specific DNA binding site [nucleotide binding]; other site 56107001212 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107001213 putative active site [active] 56107001214 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 56107001215 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 56107001216 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 56107001217 active site 56107001218 substrate binding site [chemical binding]; other site 56107001219 FMN binding site [chemical binding]; other site 56107001220 putative catalytic residues [active] 56107001221 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107001222 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 56107001223 Transposase IS200 like; Region: Y1_Tnp; pfam01797 56107001224 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 56107001225 Stage II sporulation protein; Region: SpoIID; pfam08486 56107001226 TMPIT-like protein; Region: TMPIT; pfam07851 56107001227 Epoxide hydrolase N terminus; Region: EHN; pfam06441 56107001228 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 56107001229 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 56107001230 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 56107001231 Hexamer interface [polypeptide binding]; other site 56107001232 Hexagonal pore residue; other site 56107001233 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 56107001234 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 56107001235 Hexamer interface [polypeptide binding]; other site 56107001236 Hexagonal pore residue; other site 56107001237 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 56107001238 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107001239 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107001240 ligand binding site [chemical binding]; other site 56107001241 flexible hinge region; other site 56107001242 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 56107001243 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 56107001244 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 56107001245 protein binding site [polypeptide binding]; other site 56107001246 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 56107001247 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 56107001248 Predicted transcriptional regulator [Transcription]; Region: COG3682 56107001249 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 56107001250 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 56107001251 AAA ATPase domain; Region: AAA_16; pfam13191 56107001252 YacP-like NYN domain; Region: NYN_YacP; cl01491 56107001253 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 56107001254 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 56107001255 Walker A/P-loop; other site 56107001256 ATP binding site [chemical binding]; other site 56107001257 Q-loop/lid; other site 56107001258 ABC transporter signature motif; other site 56107001259 Walker B; other site 56107001260 D-loop; other site 56107001261 H-loop/switch region; other site 56107001262 hypothetical protein; Provisional; Region: PRK13683 56107001263 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 56107001264 D1 interface; other site 56107001265 chlorophyll binding site; other site 56107001266 pheophytin binding site; other site 56107001267 beta carotene binding site; other site 56107001268 cytochrome b559 beta interface; other site 56107001269 quinone binding site; other site 56107001270 cytochrome b559 alpha interface; other site 56107001271 protein J interface; other site 56107001272 protein H interface; other site 56107001273 protein X interface; other site 56107001274 core light harvesting protein interface; other site 56107001275 protein L interface; other site 56107001276 CP43 interface; other site 56107001277 protein T interface; other site 56107001278 Fe binding site [ion binding]; other site 56107001279 protein M interface; other site 56107001280 Mn-stabilizing polypeptide interface; other site 56107001281 bromide binding site; other site 56107001282 cytochrome c-550 interface; other site 56107001283 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 56107001284 aromatic arch; other site 56107001285 DCoH dimer interaction site [polypeptide binding]; other site 56107001286 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 56107001287 DCoH tetramer interaction site [polypeptide binding]; other site 56107001288 substrate binding site [chemical binding]; other site 56107001289 S-layer homology domain; Region: SLH; pfam00395 56107001290 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 56107001291 Predicted transcriptional regulator [Transcription]; Region: COG1959 56107001292 Transcriptional regulator; Region: Rrf2; pfam02082 56107001293 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 56107001294 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 56107001295 dimer interface [polypeptide binding]; other site 56107001296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107001297 catalytic residue [active] 56107001298 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 56107001299 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107001300 HSP70 interaction site [polypeptide binding]; other site 56107001301 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 56107001302 active site 56107001303 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 56107001304 active site 56107001305 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 56107001306 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107001307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107001308 S-adenosylmethionine binding site [chemical binding]; other site 56107001309 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 56107001310 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 56107001311 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 56107001312 Zn binding site [ion binding]; other site 56107001313 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 56107001314 LVIVD repeat; Region: LVIVD; pfam08309 56107001315 Uncharacterized conserved protein [Function unknown]; Region: COG5276 56107001316 LVIVD repeat; Region: LVIVD; pfam08309 56107001317 LVIVD repeat; Region: LVIVD; pfam08309 56107001318 LVIVD repeat; Region: LVIVD; pfam08309 56107001319 LVIVD repeat; Region: LVIVD; pfam08309 56107001320 LVIVD repeat; Region: LVIVD; pfam08309 56107001321 LVIVD repeat; Region: LVIVD; pfam08309 56107001322 LVIVD repeat; Region: LVIVD; pfam08309 56107001323 LVIVD repeat; Region: LVIVD; pfam08309 56107001324 LVIVD repeat; Region: LVIVD; pfam08309 56107001325 LVIVD repeat; Region: LVIVD; pfam08309 56107001326 LVIVD repeat; Region: LVIVD; pfam08309 56107001327 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107001328 Ca2+ binding site [ion binding]; other site 56107001329 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107001330 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107001331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107001332 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 56107001333 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 56107001334 Chain length determinant protein; Region: Wzz; pfam02706 56107001335 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 56107001336 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107001337 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 56107001338 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 56107001339 Acyltransferase family; Region: Acyl_transf_3; pfam01757 56107001340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107001341 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 56107001342 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107001343 active site 56107001344 Core-2/I-Branching enzyme; Region: Branch; pfam02485 56107001345 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 56107001346 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 56107001347 active site 56107001348 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107001349 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107001350 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 56107001351 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 56107001352 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 56107001353 ABC1 family; Region: ABC1; cl17513 56107001354 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 56107001355 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 56107001356 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 56107001357 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107001358 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 56107001359 Walker A/P-loop; other site 56107001360 ATP binding site [chemical binding]; other site 56107001361 Q-loop/lid; other site 56107001362 ABC transporter signature motif; other site 56107001363 Walker B; other site 56107001364 D-loop; other site 56107001365 H-loop/switch region; other site 56107001366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107001367 dimer interface [polypeptide binding]; other site 56107001368 phosphorylation site [posttranslational modification] 56107001369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107001370 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107001371 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107001372 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107001373 active site 56107001374 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 56107001375 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 56107001376 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 56107001377 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 56107001378 replicative DNA helicase; Validated; Region: PRK07773 56107001379 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 56107001380 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 56107001381 Walker A motif; other site 56107001382 ATP binding site [chemical binding]; other site 56107001383 Walker B motif; other site 56107001384 DNA binding loops [nucleotide binding] 56107001385 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 56107001386 protein-splicing catalytic site; other site 56107001387 thioester formation/cholesterol transfer; other site 56107001388 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 56107001389 protein-splicing catalytic site; other site 56107001390 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 56107001391 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 56107001392 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 56107001393 Uncharacterized conserved protein [Function unknown]; Region: COG3937 56107001394 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 56107001395 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 56107001396 folate binding site [chemical binding]; other site 56107001397 NADP+ binding site [chemical binding]; other site 56107001398 fzo-like conserved region; Region: Fzo_mitofusin; pfam04799 56107001399 Double zinc ribbon; Region: DZR; pfam12773 56107001400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107001401 dimerization interface [polypeptide binding]; other site 56107001402 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107001403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107001404 putative active site [active] 56107001405 heme pocket [chemical binding]; other site 56107001406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107001407 dimer interface [polypeptide binding]; other site 56107001408 phosphorylation site [posttranslational modification] 56107001409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107001410 ATP binding site [chemical binding]; other site 56107001411 Mg2+ binding site [ion binding]; other site 56107001412 G-X-G motif; other site 56107001413 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 56107001414 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 56107001415 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 56107001416 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 56107001417 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 56107001418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107001419 NAD(P) binding site [chemical binding]; other site 56107001420 active site 56107001421 Uncharacterized conserved protein [Function unknown]; Region: COG3287 56107001422 FIST N domain; Region: FIST; pfam08495 56107001423 FIST C domain; Region: FIST_C; pfam10442 56107001424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107001425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107001426 dimer interface [polypeptide binding]; other site 56107001427 phosphorylation site [posttranslational modification] 56107001428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107001429 ATP binding site [chemical binding]; other site 56107001430 Mg2+ binding site [ion binding]; other site 56107001431 G-X-G motif; other site 56107001432 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107001433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107001434 active site 56107001435 phosphorylation site [posttranslational modification] 56107001436 intermolecular recognition site; other site 56107001437 dimerization interface [polypeptide binding]; other site 56107001438 Response regulator receiver domain; Region: Response_reg; pfam00072 56107001439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107001440 active site 56107001441 phosphorylation site [posttranslational modification] 56107001442 intermolecular recognition site; other site 56107001443 dimerization interface [polypeptide binding]; other site 56107001444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107001445 ATP binding site [chemical binding]; other site 56107001446 Mg2+ binding site [ion binding]; other site 56107001447 G-X-G motif; other site 56107001448 Alcohol acetyltransferase; Region: AATase; pfam07247 56107001449 RNA polymerase sigma factor; Provisional; Region: PRK12519 56107001450 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 56107001451 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 56107001452 DNA binding residues [nucleotide binding] 56107001453 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 56107001454 dinuclear metal binding motif [ion binding]; other site 56107001455 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 56107001456 TPR repeat; Region: TPR_11; pfam13414 56107001457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107001458 TPR motif; other site 56107001459 binding surface 56107001460 High-affinity nickel-transport protein; Region: NicO; cl00964 56107001461 acyl-CoA synthetase; Validated; Region: PRK05850 56107001462 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 56107001463 acyl-activating enzyme (AAE) consensus motif; other site 56107001464 active site 56107001465 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 56107001466 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 56107001467 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 56107001468 active site 56107001469 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107001470 thioester reductase domain; Region: Thioester-redct; TIGR01746 56107001471 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 56107001472 putative NAD(P) binding site [chemical binding]; other site 56107001473 active site 56107001474 putative substrate binding site [chemical binding]; other site 56107001475 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 56107001476 DNA photolyase; Region: DNA_photolyase; pfam00875 56107001477 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 56107001478 Family description; Region: VCBS; pfam13517 56107001479 Family description; Region: VCBS; pfam13517 56107001480 VCBS repeat; Region: VCBS_repeat; TIGR01965 56107001481 Family description; Region: VCBS; pfam13517 56107001482 Family description; Region: VCBS; pfam13517 56107001483 VCBS repeat; Region: VCBS_repeat; TIGR01965 56107001484 TIGR03032 family protein; Region: TIGR03032 56107001485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107001486 Coenzyme A binding pocket [chemical binding]; other site 56107001487 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 56107001488 Cupin domain; Region: Cupin_2; cl17218 56107001489 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 56107001490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107001491 FeS/SAM binding site; other site 56107001492 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 56107001493 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 56107001494 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 56107001495 homodimer interface [polypeptide binding]; other site 56107001496 substrate-cofactor binding pocket; other site 56107001497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107001498 catalytic residue [active] 56107001499 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 56107001500 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 56107001501 dimer interface [polypeptide binding]; other site 56107001502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107001503 catalytic residue [active] 56107001504 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 56107001505 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 56107001506 Protein kinase domain; Region: Pkinase; pfam00069 56107001507 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107001508 active site 56107001509 ATP binding site [chemical binding]; other site 56107001510 substrate binding site [chemical binding]; other site 56107001511 activation loop (A-loop); other site 56107001512 AAA ATPase domain; Region: AAA_16; pfam13191 56107001513 Predicted ATPase [General function prediction only]; Region: COG3899 56107001514 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107001515 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107001516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107001517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107001518 ATP binding site [chemical binding]; other site 56107001519 Mg2+ binding site [ion binding]; other site 56107001520 G-X-G motif; other site 56107001521 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 56107001522 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 56107001523 PYR/PP interface [polypeptide binding]; other site 56107001524 dimer interface [polypeptide binding]; other site 56107001525 TPP binding site [chemical binding]; other site 56107001526 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 56107001527 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 56107001528 TPP-binding site [chemical binding]; other site 56107001529 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 56107001530 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 56107001531 active site 56107001532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107001533 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107001534 putative active site [active] 56107001535 heme pocket [chemical binding]; other site 56107001536 PAS fold; Region: PAS_4; pfam08448 56107001537 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107001538 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107001539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107001540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107001541 dimer interface [polypeptide binding]; other site 56107001542 phosphorylation site [posttranslational modification] 56107001543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107001544 ATP binding site [chemical binding]; other site 56107001545 Mg2+ binding site [ion binding]; other site 56107001546 G-X-G motif; other site 56107001547 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 56107001548 G1 box; other site 56107001549 GTP/Mg2+ binding site [chemical binding]; other site 56107001550 G2 box; other site 56107001551 Switch I region; other site 56107001552 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 56107001553 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 56107001554 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 56107001555 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 56107001556 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 56107001557 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 56107001558 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 56107001559 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 56107001560 catalytic motif [active] 56107001561 Catalytic residue [active] 56107001562 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 56107001563 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 56107001564 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 56107001565 catalytic site [active] 56107001566 subunit interface [polypeptide binding]; other site 56107001567 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 56107001568 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 56107001569 anti sigma factor interaction site; other site 56107001570 regulatory phosphorylation site [posttranslational modification]; other site 56107001571 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 56107001572 active site 56107001573 metal binding site [ion binding]; metal-binding site 56107001574 dimerization interface [polypeptide binding]; other site 56107001575 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 56107001576 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 56107001577 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 56107001578 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 56107001579 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 56107001580 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 56107001581 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 56107001582 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 56107001583 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 56107001584 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 56107001585 Rhodanese Homology Domain; Region: RHOD; smart00450 56107001586 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 56107001587 active site residue [active] 56107001588 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 56107001589 active site residue [active] 56107001590 Transposase IS200 like; Region: Y1_Tnp; cl00848 56107001591 HEAT repeats; Region: HEAT_2; pfam13646 56107001592 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 56107001593 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 56107001594 active site 56107001595 PHP Thumb interface [polypeptide binding]; other site 56107001596 metal binding site [ion binding]; metal-binding site 56107001597 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 56107001598 protein-splicing catalytic site; other site 56107001599 thioester formation/cholesterol transfer; other site 56107001600 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 56107001601 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 56107001602 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 56107001603 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 56107001604 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 56107001605 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 56107001606 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 56107001607 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 56107001608 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 56107001609 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 56107001610 Homeodomain-like domain; Region: HTH_23; pfam13384 56107001611 Winged helix-turn helix; Region: HTH_29; pfam13551 56107001612 Homeodomain-like domain; Region: HTH_32; pfam13565 56107001613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107001614 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107001615 Probable transposase; Region: OrfB_IS605; pfam01385 56107001616 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107001617 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 56107001618 core domain interface [polypeptide binding]; other site 56107001619 delta subunit interface [polypeptide binding]; other site 56107001620 epsilon subunit interface [polypeptide binding]; other site 56107001621 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 56107001622 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 56107001623 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 56107001624 beta subunit interaction interface [polypeptide binding]; other site 56107001625 Walker A motif; other site 56107001626 ATP binding site [chemical binding]; other site 56107001627 Walker B motif; other site 56107001628 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 56107001629 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 56107001630 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 56107001631 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 56107001632 ATP synthase CF0 B subunit; Region: atpF; CHL00019 56107001633 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 56107001634 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 56107001635 ATP synthase CF0 C subunit; Region: atpH; CHL00061 56107001636 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 56107001637 ATP synthase CF0 A subunit; Region: atpI; CHL00046 56107001638 ATP synthase I chain; Region: ATP_synt_I; pfam03899 56107001639 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107001640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107001641 S-adenosylmethionine binding site [chemical binding]; other site 56107001642 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 56107001643 phycobillisome linker protein; Region: apcE; CHL00091 56107001644 Phycobilisome protein; Region: Phycobilisome; cl08227 56107001645 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 56107001646 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 56107001647 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 56107001648 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 56107001649 Phycobilisome protein; Region: Phycobilisome; cl08227 56107001650 Phycobilisome protein; Region: Phycobilisome; cl08227 56107001651 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 56107001652 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 56107001653 Protein of unknown function (DUF423); Region: DUF423; pfam04241 56107001654 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107001655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107001656 Probable transposase; Region: OrfB_IS605; pfam01385 56107001657 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107001658 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 56107001659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107001660 S-adenosylmethionine binding site [chemical binding]; other site 56107001661 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 56107001662 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 56107001663 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 56107001664 active site 56107001665 dimer interface [polypeptide binding]; other site 56107001666 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 56107001667 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 56107001668 NIL domain; Region: NIL; pfam09383 56107001669 sulfate transport protein; Provisional; Region: cysT; CHL00187 56107001670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107001671 dimer interface [polypeptide binding]; other site 56107001672 conserved gate region; other site 56107001673 putative PBP binding loops; other site 56107001674 ABC-ATPase subunit interface; other site 56107001675 sulfate transport protein; Provisional; Region: cysT; CHL00187 56107001676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107001677 dimer interface [polypeptide binding]; other site 56107001678 conserved gate region; other site 56107001679 putative PBP binding loops; other site 56107001680 ABC-ATPase subunit interface; other site 56107001681 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 56107001682 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 56107001683 Response regulator receiver domain; Region: Response_reg; pfam00072 56107001684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107001685 active site 56107001686 phosphorylation site [posttranslational modification] 56107001687 intermolecular recognition site; other site 56107001688 dimerization interface [polypeptide binding]; other site 56107001689 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 56107001690 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 56107001691 putative active site [active] 56107001692 putative dimer interface [polypeptide binding]; other site 56107001693 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 56107001694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107001695 motif II; other site 56107001696 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 56107001697 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 56107001698 Surface antigen; Region: Bac_surface_Ag; pfam01103 56107001699 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 56107001700 threonine synthase; Reviewed; Region: PRK06721 56107001701 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 56107001702 homodimer interface [polypeptide binding]; other site 56107001703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107001704 catalytic residue [active] 56107001705 S-layer homology domain; Region: SLH; pfam00395 56107001706 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 56107001707 nitrogenase reductase; Reviewed; Region: PRK13236 56107001708 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 56107001709 Nucleotide-binding sites [chemical binding]; other site 56107001710 Walker A motif; other site 56107001711 Switch I region of nucleotide binding site; other site 56107001712 Fe4S4 binding sites [ion binding]; other site 56107001713 Switch II region of nucleotide binding site; other site 56107001714 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 56107001715 Cadmium resistance transporter; Region: Cad; pfam03596 56107001716 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 56107001717 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 56107001718 nucleotide binding site/active site [active] 56107001719 HIT family signature motif; other site 56107001720 catalytic residue [active] 56107001721 Protein of unknown function DUF72; Region: DUF72; pfam01904 56107001722 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 56107001723 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 56107001724 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 56107001725 active site 56107001726 catalytic triad [active] 56107001727 oxyanion hole [active] 56107001728 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 56107001729 Conserved TM helix; Region: TM_helix; pfam05552 56107001730 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 56107001731 Mechanosensitive ion channel; Region: MS_channel; pfam00924 56107001732 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 56107001733 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 56107001734 phosphopeptide binding site; other site 56107001735 PAS domain S-box; Region: sensory_box; TIGR00229 56107001736 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107001737 GAF domain; Region: GAF; pfam01590 56107001738 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 56107001739 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 56107001740 metal binding site [ion binding]; metal-binding site 56107001741 active site 56107001742 I-site; other site 56107001743 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 56107001744 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 56107001745 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 56107001746 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 56107001747 recombinase A; Provisional; Region: recA; PRK09354 56107001748 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 56107001749 hexamer interface [polypeptide binding]; other site 56107001750 Walker A motif; other site 56107001751 ATP binding site [chemical binding]; other site 56107001752 Walker B motif; other site 56107001753 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 56107001754 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 56107001755 Protein of unknown function DUF58; Region: DUF58; pfam01882 56107001756 MoxR-like ATPases [General function prediction only]; Region: COG0714 56107001757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107001758 Walker A motif; other site 56107001759 ATP binding site [chemical binding]; other site 56107001760 Walker B motif; other site 56107001761 arginine finger; other site 56107001762 HNH endonuclease; Region: HNH_2; pfam13391 56107001763 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 56107001764 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 56107001765 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 56107001766 generic binding surface II; other site 56107001767 generic binding surface I; other site 56107001768 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 56107001769 sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485 56107001770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 56107001771 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 56107001772 RuvA N terminal domain; Region: RuvA_N; pfam01330 56107001773 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 56107001774 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 56107001775 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 56107001776 substrate-cofactor binding pocket; other site 56107001777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107001778 catalytic residue [active] 56107001779 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 56107001780 PAS fold; Region: PAS_4; pfam08448 56107001781 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107001782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107001783 putative active site [active] 56107001784 heme pocket [chemical binding]; other site 56107001785 PAS domain S-box; Region: sensory_box; TIGR00229 56107001786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107001787 putative active site [active] 56107001788 heme pocket [chemical binding]; other site 56107001789 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107001790 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107001791 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107001792 GAF domain; Region: GAF; pfam01590 56107001793 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107001794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107001795 dimer interface [polypeptide binding]; other site 56107001796 phosphorylation site [posttranslational modification] 56107001797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107001798 ATP binding site [chemical binding]; other site 56107001799 Mg2+ binding site [ion binding]; other site 56107001800 G-X-G motif; other site 56107001801 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107001802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107001803 active site 56107001804 phosphorylation site [posttranslational modification] 56107001805 intermolecular recognition site; other site 56107001806 dimerization interface [polypeptide binding]; other site 56107001807 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107001808 putative active site [active] 56107001809 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 56107001810 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 56107001811 tetramer interface [polypeptide binding]; other site 56107001812 active site 56107001813 Mg2+/Mn2+ binding site [ion binding]; other site 56107001814 Red chlorophyll catabolite reductase (RCC reductase); Region: RCC_reductase; cl05747 56107001815 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 56107001816 Predicted amidohydrolase [General function prediction only]; Region: COG0388 56107001817 putative active site [active] 56107001818 catalytic triad [active] 56107001819 putative dimer interface [polypeptide binding]; other site 56107001820 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 56107001821 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 56107001822 NAD(P) binding site [chemical binding]; other site 56107001823 catalytic residues [active] 56107001824 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 56107001825 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 56107001826 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 56107001827 dimer interface [polypeptide binding]; other site 56107001828 motif 1; other site 56107001829 active site 56107001830 motif 2; other site 56107001831 motif 3; other site 56107001832 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 56107001833 anticodon binding site; other site 56107001834 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 56107001835 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 56107001836 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107001837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107001838 S-adenosylmethionine binding site [chemical binding]; other site 56107001839 SnoaL-like domain; Region: SnoaL_2; pfam12680 56107001840 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107001841 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 56107001842 G1 box; other site 56107001843 GTP/Mg2+ binding site [chemical binding]; other site 56107001844 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107001845 WD domain, G-beta repeat; Region: WD40; pfam00400 56107001846 WD domain, G-beta repeat; Region: WD40; pfam00400 56107001847 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107001848 structural tetrad; other site 56107001849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107001850 binding surface 56107001851 TPR motif; other site 56107001852 Tetratricopeptide repeat; Region: TPR_9; pfam13371 56107001853 MFS/sugar transport protein; Region: MFS_2; pfam13347 56107001854 hypothetical protein; Validated; Region: PRK07411 56107001855 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 56107001856 ATP binding site [chemical binding]; other site 56107001857 substrate interface [chemical binding]; other site 56107001858 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 56107001859 active site residue [active] 56107001860 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 56107001861 MPN+ (JAMM) motif; other site 56107001862 Zinc-binding site [ion binding]; other site 56107001863 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 56107001864 four helix bundle protein; Region: TIGR02436 56107001865 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 56107001866 active site clefts [active] 56107001867 zinc binding site [ion binding]; other site 56107001868 dimer interface [polypeptide binding]; other site 56107001869 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 56107001870 active site clefts [active] 56107001871 zinc binding site [ion binding]; other site 56107001872 dimer interface [polypeptide binding]; other site 56107001873 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 56107001874 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 56107001875 Walker A/P-loop; other site 56107001876 ATP binding site [chemical binding]; other site 56107001877 Q-loop/lid; other site 56107001878 ABC transporter signature motif; other site 56107001879 Walker B; other site 56107001880 D-loop; other site 56107001881 H-loop/switch region; other site 56107001882 Ferredoxin [Energy production and conversion]; Region: COG1146 56107001883 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 56107001884 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 56107001885 dimer interface [polypeptide binding]; other site 56107001886 motif 1; other site 56107001887 active site 56107001888 motif 2; other site 56107001889 motif 3; other site 56107001890 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 56107001891 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107001892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107001893 binding surface 56107001894 TPR motif; other site 56107001895 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 56107001896 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 56107001897 active site 56107001898 dimerization interface [polypeptide binding]; other site 56107001899 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 56107001900 Catalytic site; other site 56107001901 Staphylococcal nuclease homologue; Region: SNase; pfam00565 56107001902 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 56107001903 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 56107001904 catalytic loop [active] 56107001905 iron binding site [ion binding]; other site 56107001906 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 56107001907 iron-sulfur cluster [ion binding]; other site 56107001908 [2Fe-2S] cluster binding site [ion binding]; other site 56107001909 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 56107001910 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 56107001911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107001912 Coenzyme A binding pocket [chemical binding]; other site 56107001913 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 56107001914 Transglycosylase; Region: Transgly; pfam00912 56107001915 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 56107001916 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 56107001917 von Willebrand factor; Region: vWF_A; pfam12450 56107001918 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 56107001919 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 56107001920 metal ion-dependent adhesion site (MIDAS); other site 56107001921 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 56107001922 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 56107001923 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 56107001924 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 56107001925 active site 56107001926 metal binding site [ion binding]; metal-binding site 56107001927 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 56107001928 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 56107001929 active site 56107001930 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 56107001931 Bacterial Ig-like domain; Region: Big_5; pfam13205 56107001932 MG2 domain; Region: A2M_N; pfam01835 56107001933 Alpha-2-macroglobulin family; Region: A2M; pfam00207 56107001934 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 56107001935 surface patch; other site 56107001936 specificity defining residues; other site 56107001937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107001938 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107001939 dimerization interface [polypeptide binding]; other site 56107001940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107001941 dimer interface [polypeptide binding]; other site 56107001942 phosphorylation site [posttranslational modification] 56107001943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107001944 ATP binding site [chemical binding]; other site 56107001945 Mg2+ binding site [ion binding]; other site 56107001946 G-X-G motif; other site 56107001947 Response regulator receiver domain; Region: Response_reg; pfam00072 56107001948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107001949 active site 56107001950 phosphorylation site [posttranslational modification] 56107001951 intermolecular recognition site; other site 56107001952 dimerization interface [polypeptide binding]; other site 56107001953 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107001954 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107001955 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107001956 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107001957 PAS fold; Region: PAS; pfam00989 56107001958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107001959 putative active site [active] 56107001960 heme pocket [chemical binding]; other site 56107001961 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 56107001962 cyclase homology domain; Region: CHD; cd07302 56107001963 nucleotidyl binding site; other site 56107001964 metal binding site [ion binding]; metal-binding site 56107001965 dimer interface [polypeptide binding]; other site 56107001966 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 56107001967 Predicted membrane protein [Function unknown]; Region: COG2119 56107001968 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 56107001969 Predicted membrane protein [Function unknown]; Region: COG2119 56107001970 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 56107001971 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107001972 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107001973 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107001974 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107001975 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107001976 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 56107001977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107001978 Walker A/P-loop; other site 56107001979 ATP binding site [chemical binding]; other site 56107001980 Q-loop/lid; other site 56107001981 ABC transporter signature motif; other site 56107001982 Walker B; other site 56107001983 D-loop; other site 56107001984 H-loop/switch region; other site 56107001985 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 56107001986 Phytase; Region: Phytase; cl17685 56107001987 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 56107001988 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 56107001989 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107001990 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107001991 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107001992 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107001993 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107001994 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 56107001995 oxyanion hole [active] 56107001996 catalytic triad [active] 56107001997 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 56107001998 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 56107001999 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 56107002000 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 56107002001 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107002002 NlpC/P60 family; Region: NLPC_P60; cl17555 56107002003 transglutaminase; Provisional; Region: tgl; PRK03187 56107002004 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 56107002005 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 56107002006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107002007 Walker A motif; other site 56107002008 ATP binding site [chemical binding]; other site 56107002009 Walker B motif; other site 56107002010 arginine finger; other site 56107002011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107002012 Probable transposase; Region: OrfB_IS605; pfam01385 56107002013 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 56107002014 putative lipid kinase; Reviewed; Region: PRK13057 56107002015 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 56107002016 NTPase; Region: NTPase_1; cl17478 56107002017 NACHT domain; Region: NACHT; pfam05729 56107002018 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 56107002019 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 56107002020 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 56107002021 phosphopeptide binding site; other site 56107002022 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107002023 dimerization interface [polypeptide binding]; other site 56107002024 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107002025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 56107002026 putative active site [active] 56107002027 heme pocket [chemical binding]; other site 56107002028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 56107002029 dimer interface [polypeptide binding]; other site 56107002030 phosphorylation site [posttranslational modification] 56107002031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107002032 ATP binding site [chemical binding]; other site 56107002033 Mg2+ binding site [ion binding]; other site 56107002034 G-X-G motif; other site 56107002035 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 56107002036 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107002037 membrane-bound complex binding site; other site 56107002038 hinge residues; other site 56107002039 PAS domain S-box; Region: sensory_box; TIGR00229 56107002040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107002041 putative active site [active] 56107002042 heme pocket [chemical binding]; other site 56107002043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107002044 PAS domain; Region: PAS_9; pfam13426 56107002045 putative active site [active] 56107002046 heme pocket [chemical binding]; other site 56107002047 GAF domain; Region: GAF_3; pfam13492 56107002048 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107002049 GAF domain; Region: GAF; pfam01590 56107002050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107002051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107002052 dimer interface [polypeptide binding]; other site 56107002053 phosphorylation site [posttranslational modification] 56107002054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107002055 ATP binding site [chemical binding]; other site 56107002056 Mg2+ binding site [ion binding]; other site 56107002057 G-X-G motif; other site 56107002058 NurA nuclease; Region: NurA; smart00933 56107002059 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 56107002060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 56107002061 active site 56107002062 motif I; other site 56107002063 motif II; other site 56107002064 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107002065 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107002066 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107002067 TPR repeat; Region: TPR_11; pfam13414 56107002068 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 56107002069 active site 56107002070 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 56107002071 homodecamer interface [polypeptide binding]; other site 56107002072 GTP cyclohydrolase I; Provisional; Region: PLN03044 56107002073 active site 56107002074 putative catalytic site residues [active] 56107002075 zinc binding site [ion binding]; other site 56107002076 GTP-CH-I/GFRP interaction surface; other site 56107002077 short chain dehydrogenase; Provisional; Region: PRK07454 56107002078 classical (c) SDRs; Region: SDR_c; cd05233 56107002079 NAD(P) binding site [chemical binding]; other site 56107002080 active site 56107002081 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 56107002082 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 56107002083 acyl-ACP reductase; Provisional; Region: PRK14982 56107002084 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 56107002085 NAD(P) binding pocket [chemical binding]; other site 56107002086 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 56107002087 dinuclear metal binding motif [ion binding]; other site 56107002088 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 56107002089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107002090 dimer interface [polypeptide binding]; other site 56107002091 conserved gate region; other site 56107002092 putative PBP binding loops; other site 56107002093 ABC-ATPase subunit interface; other site 56107002094 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107002095 putative active site [active] 56107002096 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 56107002097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107002098 FeS/SAM binding site; other site 56107002099 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 56107002100 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 56107002101 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 56107002102 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 56107002103 RNA binding surface [nucleotide binding]; other site 56107002104 heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245 56107002105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 56107002106 JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744 56107002107 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 56107002108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107002109 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 56107002110 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 56107002111 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 56107002112 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 56107002113 putative NAD(P) binding site [chemical binding]; other site 56107002114 catalytic Zn binding site [ion binding]; other site 56107002115 pheophorbide a oxygenase; Region: PLN02518 56107002116 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 56107002117 iron-sulfur cluster [ion binding]; other site 56107002118 [2Fe-2S] cluster binding site [ion binding]; other site 56107002119 Pheophorbide a oxygenase; Region: PaO; pfam08417 56107002120 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 56107002121 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107002122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107002123 S-adenosylmethionine binding site [chemical binding]; other site 56107002124 glutamine synthetase, type I; Region: GlnA; TIGR00653 56107002125 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 56107002126 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 56107002127 allophycocyanin, beta subunit; Region: apcB; TIGR01337 56107002128 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107002129 putative active site [active] 56107002130 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107002131 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 56107002132 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 56107002133 RNA binding surface [nucleotide binding]; other site 56107002134 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 56107002135 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107002136 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 56107002137 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 56107002138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 56107002139 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 56107002140 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 56107002141 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 56107002142 active site 56107002143 catalytic site [active] 56107002144 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 56107002145 calcium/proton exchanger (cax); Region: cax; TIGR00378 56107002146 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 56107002147 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 56107002148 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107002149 sucrose synthase; Region: sucr_synth; TIGR02470 56107002150 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 56107002151 putative ADP-binding pocket [chemical binding]; other site 56107002152 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 56107002153 Protein kinase domain; Region: Pkinase; pfam00069 56107002154 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107002155 active site 56107002156 ATP binding site [chemical binding]; other site 56107002157 substrate binding site [chemical binding]; other site 56107002158 activation loop (A-loop); other site 56107002159 GUN4-like; Region: GUN4; pfam05419 56107002160 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 56107002161 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 56107002162 putative active site [active] 56107002163 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 56107002164 putative active site [active] 56107002165 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 56107002166 active site 56107002167 SAM binding site [chemical binding]; other site 56107002168 homodimer interface [polypeptide binding]; other site 56107002169 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107002170 Probable transposase; Region: OrfB_IS605; pfam01385 56107002171 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107002172 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 56107002173 PAS domain S-box; Region: sensory_box; TIGR00229 56107002174 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107002175 putative active site [active] 56107002176 heme pocket [chemical binding]; other site 56107002177 PAS domain; Region: PAS_8; pfam13188 56107002178 PAS domain; Region: PAS_9; pfam13426 56107002179 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107002180 GAF domain; Region: GAF; pfam01590 56107002181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107002182 PAS fold; Region: PAS_3; pfam08447 56107002183 putative active site [active] 56107002184 heme pocket [chemical binding]; other site 56107002185 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107002186 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107002187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107002188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107002189 dimer interface [polypeptide binding]; other site 56107002190 phosphorylation site [posttranslational modification] 56107002191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107002192 ATP binding site [chemical binding]; other site 56107002193 Mg2+ binding site [ion binding]; other site 56107002194 G-X-G motif; other site 56107002195 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107002196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107002197 active site 56107002198 phosphorylation site [posttranslational modification] 56107002199 intermolecular recognition site; other site 56107002200 dimerization interface [polypeptide binding]; other site 56107002201 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 56107002202 active site clefts [active] 56107002203 zinc binding site [ion binding]; other site 56107002204 dimer interface [polypeptide binding]; other site 56107002205 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 56107002206 Response regulator receiver domain; Region: Response_reg; pfam00072 56107002207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107002208 active site 56107002209 phosphorylation site [posttranslational modification] 56107002210 intermolecular recognition site; other site 56107002211 dimerization interface [polypeptide binding]; other site 56107002212 TPR repeat; Region: TPR_11; pfam13414 56107002213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002214 binding surface 56107002215 TPR motif; other site 56107002216 TPR repeat; Region: TPR_11; pfam13414 56107002217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002218 binding surface 56107002219 TPR motif; other site 56107002220 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 56107002221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002222 binding surface 56107002223 TPR motif; other site 56107002224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002225 binding surface 56107002226 TPR motif; other site 56107002227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002228 binding surface 56107002229 TPR motif; other site 56107002230 CHAT domain; Region: CHAT; cl17868 56107002231 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 56107002232 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107002233 putative active site [active] 56107002234 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 56107002235 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 56107002236 RNA binding surface [nucleotide binding]; other site 56107002237 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 56107002238 active site 56107002239 Phycobilisome protein; Region: Phycobilisome; cl08227 56107002240 Phycobilisome protein; Region: Phycobilisome; cl08227 56107002241 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 56107002242 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 56107002243 HEAT repeats; Region: HEAT_2; pfam13646 56107002244 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 56107002245 HEAT repeats; Region: HEAT_2; pfam13646 56107002246 HEAT repeats; Region: HEAT_2; pfam13646 56107002247 HEAT repeats; Region: HEAT_2; pfam13646 56107002248 HEAT repeats; Region: HEAT_2; pfam13646 56107002249 phycocyanin beta subunit; Reviewed; Region: cpcB; CHL00171 56107002250 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 56107002251 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 56107002252 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 56107002253 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 56107002254 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 56107002255 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 56107002256 HEAT repeats; Region: HEAT_2; pfam13646 56107002257 HEAT repeats; Region: HEAT_2; pfam13646 56107002258 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 56107002259 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 56107002260 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 56107002261 TPR repeat; Region: TPR_11; pfam13414 56107002262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002263 binding surface 56107002264 TPR motif; other site 56107002265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002266 binding surface 56107002267 TPR motif; other site 56107002268 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002270 TPR motif; other site 56107002271 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002272 binding surface 56107002273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 56107002274 CHAT domain; Region: CHAT; cl17868 56107002275 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 56107002276 CHASE2 domain; Region: CHASE2; pfam05226 56107002277 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 56107002278 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 56107002279 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 56107002280 haemagglutination activity domain; Region: Haemagg_act; pfam05860 56107002281 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 56107002282 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107002283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107002284 active site 56107002285 phosphorylation site [posttranslational modification] 56107002286 intermolecular recognition site; other site 56107002287 dimerization interface [polypeptide binding]; other site 56107002288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107002289 DNA binding site [nucleotide binding] 56107002290 Response regulator receiver domain; Region: Response_reg; pfam00072 56107002291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107002292 active site 56107002293 phosphorylation site [posttranslational modification] 56107002294 intermolecular recognition site; other site 56107002295 dimerization interface [polypeptide binding]; other site 56107002296 Response regulator receiver domain; Region: Response_reg; pfam00072 56107002297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107002298 active site 56107002299 phosphorylation site [posttranslational modification] 56107002300 intermolecular recognition site; other site 56107002301 dimerization interface [polypeptide binding]; other site 56107002302 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 56107002303 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 56107002304 metal binding site [ion binding]; metal-binding site 56107002305 active site 56107002306 I-site; other site 56107002307 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 56107002308 PAS fold; Region: PAS_4; pfam08448 56107002309 PAS fold; Region: PAS_7; pfam12860 56107002310 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107002311 GAF domain; Region: GAF_3; pfam13492 56107002312 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107002313 dimer interface [polypeptide binding]; other site 56107002314 phosphorylation site [posttranslational modification] 56107002315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107002316 ATP binding site [chemical binding]; other site 56107002317 Mg2+ binding site [ion binding]; other site 56107002318 G-X-G motif; other site 56107002319 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107002320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107002321 active site 56107002322 phosphorylation site [posttranslational modification] 56107002323 intermolecular recognition site; other site 56107002324 dimerization interface [polypeptide binding]; other site 56107002325 Response regulator receiver domain; Region: Response_reg; pfam00072 56107002326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107002327 active site 56107002328 phosphorylation site [posttranslational modification] 56107002329 intermolecular recognition site; other site 56107002330 dimerization interface [polypeptide binding]; other site 56107002331 PAS domain; Region: PAS_9; pfam13426 56107002332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107002333 putative active site [active] 56107002334 heme pocket [chemical binding]; other site 56107002335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107002336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107002337 dimer interface [polypeptide binding]; other site 56107002338 phosphorylation site [posttranslational modification] 56107002339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107002340 ATP binding site [chemical binding]; other site 56107002341 Mg2+ binding site [ion binding]; other site 56107002342 G-X-G motif; other site 56107002343 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107002344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107002345 active site 56107002346 phosphorylation site [posttranslational modification] 56107002347 intermolecular recognition site; other site 56107002348 dimerization interface [polypeptide binding]; other site 56107002349 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 56107002350 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 56107002351 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107002352 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107002353 ligand binding site [chemical binding]; other site 56107002354 flexible hinge region; other site 56107002355 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 56107002356 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 56107002357 putative active site [active] 56107002358 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107002359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107002360 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 56107002361 Walker A/P-loop; other site 56107002362 ATP binding site [chemical binding]; other site 56107002363 Q-loop/lid; other site 56107002364 ABC transporter signature motif; other site 56107002365 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107002366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 56107002367 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 56107002368 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 56107002369 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 56107002370 PYR/PP interface [polypeptide binding]; other site 56107002371 dimer interface [polypeptide binding]; other site 56107002372 TPP binding site [chemical binding]; other site 56107002373 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 56107002374 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 56107002375 TPP-binding site [chemical binding]; other site 56107002376 dimer interface [polypeptide binding]; other site 56107002377 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 56107002378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107002379 H+ Antiporter protein; Region: 2A0121; TIGR00900 56107002380 putative substrate translocation pore; other site 56107002381 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 56107002382 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 56107002383 C-terminal domain interface [polypeptide binding]; other site 56107002384 active site 56107002385 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 56107002386 active site 56107002387 N-terminal domain interface [polypeptide binding]; other site 56107002388 H+ Antiporter protein; Region: 2A0121; TIGR00900 56107002389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107002390 putative substrate translocation pore; other site 56107002391 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107002392 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 56107002393 acyl-activating enzyme (AAE) consensus motif; other site 56107002394 AMP binding site [chemical binding]; other site 56107002395 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107002396 Condensation domain; Region: Condensation; pfam00668 56107002397 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107002398 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107002399 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107002400 acyl-activating enzyme (AAE) consensus motif; other site 56107002401 AMP binding site [chemical binding]; other site 56107002402 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107002403 Condensation domain; Region: Condensation; pfam00668 56107002404 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107002405 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 56107002406 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 56107002407 Predicted flavoprotein [General function prediction only]; Region: COG0431 56107002408 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 56107002409 cell division protein; Validated; Region: ftsH; CHL00176 56107002410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107002411 Walker A motif; other site 56107002412 ATP binding site [chemical binding]; other site 56107002413 Walker B motif; other site 56107002414 arginine finger; other site 56107002415 Peptidase family M41; Region: Peptidase_M41; pfam01434 56107002416 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 56107002417 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 56107002418 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 56107002419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 56107002420 Transcriptional regulators [Transcription]; Region: GntR; COG1802 56107002421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 56107002422 DNA-binding site [nucleotide binding]; DNA binding site 56107002423 FCD domain; Region: FCD; pfam07729 56107002424 2-isopropylmalate synthase; Validated; Region: PRK00915 56107002425 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 56107002426 active site 56107002427 catalytic residues [active] 56107002428 metal binding site [ion binding]; metal-binding site 56107002429 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 56107002430 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 56107002431 KTSC domain; Region: KTSC; pfam13619 56107002432 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 56107002433 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 56107002434 Zn2+ binding site [ion binding]; other site 56107002435 Mg2+ binding site [ion binding]; other site 56107002436 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 56107002437 synthetase active site [active] 56107002438 NTP binding site [chemical binding]; other site 56107002439 metal binding site [ion binding]; metal-binding site 56107002440 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 56107002441 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 56107002442 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 56107002443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 56107002444 Walker A/P-loop; other site 56107002445 ATP binding site [chemical binding]; other site 56107002446 Q-loop/lid; other site 56107002447 ABC transporter signature motif; other site 56107002448 Walker B; other site 56107002449 D-loop; other site 56107002450 H-loop/switch region; other site 56107002451 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 56107002452 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 56107002453 Walker A/P-loop; other site 56107002454 ATP binding site [chemical binding]; other site 56107002455 Q-loop/lid; other site 56107002456 ABC transporter signature motif; other site 56107002457 Walker B; other site 56107002458 D-loop; other site 56107002459 H-loop/switch region; other site 56107002460 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 56107002461 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107002462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107002463 S-adenosylmethionine binding site [chemical binding]; other site 56107002464 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 56107002465 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 56107002466 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107002467 putative active site [active] 56107002468 XisI protein; Region: XisI; pfam08869 56107002469 XisH protein; Region: XisH; pfam08814 56107002470 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 56107002471 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 56107002472 magnesium chelatase subunit H; Provisional; Region: PRK12493 56107002473 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 56107002474 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 56107002475 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107002476 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 56107002477 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 56107002478 RDD family; Region: RDD; pfam06271 56107002479 HEAT repeats; Region: HEAT_2; pfam13646 56107002480 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107002481 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107002482 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107002483 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107002484 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107002485 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107002486 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 56107002487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 56107002488 Mg2+ binding site [ion binding]; other site 56107002489 G-X-G motif; other site 56107002490 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 56107002491 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 56107002492 interchain domain interface [polypeptide binding]; other site 56107002493 intrachain domain interface; other site 56107002494 Qi binding site; other site 56107002495 Qo binding site; other site 56107002496 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 56107002497 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 56107002498 Qi binding site; other site 56107002499 intrachain domain interface; other site 56107002500 interchain domain interface [polypeptide binding]; other site 56107002501 heme bH binding site [chemical binding]; other site 56107002502 heme bL binding site [chemical binding]; other site 56107002503 Qo binding site; other site 56107002504 carboxyl-terminal processing protease; Provisional; Region: PLN00049 56107002505 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 56107002506 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 56107002507 protein binding site [polypeptide binding]; other site 56107002508 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 56107002509 Catalytic dyad [active] 56107002510 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 56107002511 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 56107002512 Peptidase family M50; Region: Peptidase_M50; pfam02163 56107002513 active site 56107002514 putative substrate binding region [chemical binding]; other site 56107002515 CpeS-like protein; Region: CpeS; pfam09367 56107002516 HEAT repeats; Region: HEAT_2; pfam13646 56107002517 HEAT repeats; Region: HEAT_2; pfam13646 56107002518 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 56107002519 HEAT repeats; Region: HEAT_2; pfam13646 56107002520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 56107002521 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 56107002522 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 56107002523 Fasciclin domain; Region: Fasciclin; pfam02469 56107002524 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 56107002525 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 56107002526 C-terminal domain interface [polypeptide binding]; other site 56107002527 GSH binding site (G-site) [chemical binding]; other site 56107002528 dimer interface [polypeptide binding]; other site 56107002529 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 56107002530 N-terminal domain interface [polypeptide binding]; other site 56107002531 HAS barrel domain; Region: HAS-barrel; pfam09378 56107002532 HerA helicase [Replication, recombination, and repair]; Region: COG0433 56107002533 Domain of unknown function DUF87; Region: DUF87; pfam01935 56107002534 RNA polymerase sigma factor; Validated; Region: PRK05949 56107002535 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 56107002536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 56107002537 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 56107002538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 56107002539 DNA binding residues [nucleotide binding] 56107002540 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 56107002541 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 56107002542 active site 56107002543 catalytic site [active] 56107002544 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 56107002545 starch-binding site 2 [chemical binding]; other site 56107002546 starch-binding site 1 [chemical binding]; other site 56107002547 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 56107002548 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 56107002549 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 56107002550 homodimer interface [polypeptide binding]; other site 56107002551 Walker A motif; other site 56107002552 ATP binding site [chemical binding]; other site 56107002553 hydroxycobalamin binding site [chemical binding]; other site 56107002554 Walker B motif; other site 56107002555 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 56107002556 putative ADP-ribose binding site [chemical binding]; other site 56107002557 putative active site [active] 56107002558 deoxyhypusine synthase-like protein; Provisional; Region: PRK00770 56107002559 deoxyhypusine synthase; Region: dhys; TIGR00321 56107002560 CHAT domain; Region: CHAT; cl17868 56107002561 AAA ATPase domain; Region: AAA_16; pfam13191 56107002562 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002564 binding surface 56107002565 TPR motif; other site 56107002566 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002568 binding surface 56107002569 TPR motif; other site 56107002570 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002571 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002572 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002574 binding surface 56107002575 TPR motif; other site 56107002576 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002577 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 56107002578 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 56107002579 dimer interface [polypeptide binding]; other site 56107002580 putative metal binding site [ion binding]; other site 56107002581 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 56107002582 Resolvase, N terminal domain; Region: Resolvase; smart00857 56107002583 catalytic residues [active] 56107002584 Recombinase; Region: Recombinase; pfam07508 56107002585 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 56107002586 AAA domain; Region: AAA_13; pfam13166 56107002587 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 56107002588 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 56107002589 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 56107002590 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 56107002591 Cl- selectivity filter; other site 56107002592 Cl- binding residues [ion binding]; other site 56107002593 pore gating glutamate residue; other site 56107002594 dimer interface [polypeptide binding]; other site 56107002595 FOG: CBS domain [General function prediction only]; Region: COG0517 56107002596 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 56107002597 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 56107002598 Predicted transcriptional regulator [Transcription]; Region: COG1959 56107002599 Transcriptional regulator; Region: Rrf2; cl17282 56107002600 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 56107002601 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 56107002602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 56107002603 active site 56107002604 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002606 binding surface 56107002607 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002608 TPR motif; other site 56107002609 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002611 TPR motif; other site 56107002612 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002613 binding surface 56107002614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002615 binding surface 56107002616 TPR motif; other site 56107002617 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002618 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107002619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 56107002620 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 56107002621 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 56107002622 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107002623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107002624 active site 56107002625 phosphorylation site [posttranslational modification] 56107002626 intermolecular recognition site; other site 56107002627 dimerization interface [polypeptide binding]; other site 56107002628 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107002629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107002630 putative active site [active] 56107002631 heme pocket [chemical binding]; other site 56107002632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107002633 dimer interface [polypeptide binding]; other site 56107002634 phosphorylation site [posttranslational modification] 56107002635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107002636 ATP binding site [chemical binding]; other site 56107002637 Mg2+ binding site [ion binding]; other site 56107002638 G-X-G motif; other site 56107002639 Response regulator receiver domain; Region: Response_reg; pfam00072 56107002640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107002641 active site 56107002642 phosphorylation site [posttranslational modification] 56107002643 intermolecular recognition site; other site 56107002644 dimerization interface [polypeptide binding]; other site 56107002645 Response regulator receiver domain; Region: Response_reg; pfam00072 56107002646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107002647 active site 56107002648 phosphorylation site [posttranslational modification] 56107002649 intermolecular recognition site; other site 56107002650 dimerization interface [polypeptide binding]; other site 56107002651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107002652 PAS fold; Region: PAS_3; pfam08447 56107002653 putative active site [active] 56107002654 heme pocket [chemical binding]; other site 56107002655 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107002656 GAF domain; Region: GAF; pfam01590 56107002657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107002658 PAS fold; Region: PAS_3; pfam08447 56107002659 putative active site [active] 56107002660 heme pocket [chemical binding]; other site 56107002661 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107002662 PAS fold; Region: PAS_3; pfam08447 56107002663 putative active site [active] 56107002664 heme pocket [chemical binding]; other site 56107002665 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107002666 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107002667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107002668 dimer interface [polypeptide binding]; other site 56107002669 phosphorylation site [posttranslational modification] 56107002670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107002671 ATP binding site [chemical binding]; other site 56107002672 Mg2+ binding site [ion binding]; other site 56107002673 G-X-G motif; other site 56107002674 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107002675 GAF domain; Region: GAF; pfam01590 56107002676 PAS domain S-box; Region: sensory_box; TIGR00229 56107002677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 56107002678 putative active site [active] 56107002679 heme pocket [chemical binding]; other site 56107002680 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107002681 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 56107002682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107002683 putative active site [active] 56107002684 heme pocket [chemical binding]; other site 56107002685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107002686 dimer interface [polypeptide binding]; other site 56107002687 phosphorylation site [posttranslational modification] 56107002688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107002689 ATP binding site [chemical binding]; other site 56107002690 Mg2+ binding site [ion binding]; other site 56107002691 G-X-G motif; other site 56107002692 Response regulator receiver domain; Region: Response_reg; pfam00072 56107002693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107002694 active site 56107002695 phosphorylation site [posttranslational modification] 56107002696 intermolecular recognition site; other site 56107002697 dimerization interface [polypeptide binding]; other site 56107002698 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 56107002699 MoaE homodimer interface [polypeptide binding]; other site 56107002700 MoaD interaction [polypeptide binding]; other site 56107002701 active site residues [active] 56107002702 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 56107002703 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107002704 putative homodimer interface [polypeptide binding]; other site 56107002705 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 56107002706 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107002707 UDP-galactopyranose mutase; Region: GLF; pfam03275 56107002708 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 56107002709 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 56107002710 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 56107002711 NADP binding site [chemical binding]; other site 56107002712 active site 56107002713 putative substrate binding site [chemical binding]; other site 56107002714 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 56107002715 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 56107002716 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 56107002717 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 56107002718 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 56107002719 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 56107002720 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 56107002721 active site 56107002722 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 56107002723 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 56107002724 dimer interface [polypeptide binding]; other site 56107002725 active site 56107002726 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 56107002727 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 56107002728 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 56107002729 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 56107002730 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 56107002731 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 56107002732 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 56107002733 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 56107002734 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 56107002735 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 56107002736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002737 binding surface 56107002738 TPR motif; other site 56107002739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002740 binding surface 56107002741 TPR motif; other site 56107002742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107002743 binding surface 56107002744 TPR motif; other site 56107002745 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 56107002746 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 56107002747 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 56107002748 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 56107002749 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 56107002750 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 56107002751 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107002752 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 56107002753 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 56107002754 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 56107002755 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 56107002756 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 56107002757 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 56107002758 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 56107002759 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 56107002760 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 56107002761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107002762 PAS domain; Region: PAS_9; pfam13426 56107002763 putative active site [active] 56107002764 heme pocket [chemical binding]; other site 56107002765 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 56107002766 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 56107002767 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 56107002768 non-specific DNA interactions [nucleotide binding]; other site 56107002769 DNA binding site [nucleotide binding] 56107002770 sequence specific DNA binding site [nucleotide binding]; other site 56107002771 putative cAMP binding site [chemical binding]; other site 56107002772 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 56107002773 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 56107002774 putative acyl-acceptor binding pocket; other site 56107002775 Protein kinase domain; Region: Pkinase; pfam00069 56107002776 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107002777 active site 56107002778 ATP binding site [chemical binding]; other site 56107002779 substrate binding site [chemical binding]; other site 56107002780 activation loop (A-loop); other site 56107002781 GUN4-like; Region: GUN4; pfam05419 56107002782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107002783 dimerization interface [polypeptide binding]; other site 56107002784 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 56107002785 cyclase homology domain; Region: CHD; cd07302 56107002786 nucleotidyl binding site; other site 56107002787 metal binding site [ion binding]; metal-binding site 56107002788 dimer interface [polypeptide binding]; other site 56107002789 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 56107002790 metal coordination site [ion binding]; other site 56107002791 Moco binding site; other site 56107002792 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 56107002793 metal coordination site [ion binding]; other site 56107002794 Proline dehydrogenase; Region: Pro_dh; pfam01619 56107002795 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 56107002796 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 56107002797 Glutamate binding site [chemical binding]; other site 56107002798 homodimer interface [polypeptide binding]; other site 56107002799 NAD binding site [chemical binding]; other site 56107002800 catalytic residues [active] 56107002801 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107002802 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 56107002803 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 56107002804 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 56107002805 cobalamin binding residues [chemical binding]; other site 56107002806 putative BtuC binding residues; other site 56107002807 dimer interface [polypeptide binding]; other site 56107002808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107002809 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107002810 Probable transposase; Region: OrfB_IS605; pfam01385 56107002811 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107002812 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 56107002813 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 56107002814 active site 56107002815 Zn binding site [ion binding]; other site 56107002816 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 56107002817 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 56107002818 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 56107002819 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 56107002820 nucleotide binding site [chemical binding]; other site 56107002821 NEF interaction site [polypeptide binding]; other site 56107002822 SBD interface [polypeptide binding]; other site 56107002823 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 56107002824 oligomerisation interface [polypeptide binding]; other site 56107002825 mobile loop; other site 56107002826 roof hairpin; other site 56107002827 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 56107002828 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 56107002829 ring oligomerisation interface [polypeptide binding]; other site 56107002830 ATP/Mg binding site [chemical binding]; other site 56107002831 stacking interactions; other site 56107002832 hinge regions; other site 56107002833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 56107002834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 56107002835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 56107002836 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 56107002837 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 56107002838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107002839 FeS/SAM binding site; other site 56107002840 TRAM domain; Region: TRAM; pfam01938 56107002841 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 56107002842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107002843 Coenzyme A binding pocket [chemical binding]; other site 56107002844 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107002845 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 56107002846 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107002847 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 56107002848 active site 56107002849 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 56107002850 Methyltransferase domain; Region: Methyltransf_23; pfam13489 56107002851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107002852 S-adenosylmethionine binding site [chemical binding]; other site 56107002853 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107002854 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 56107002855 winged helix-turn-helix domain-containing protein/riboflavin kinase; Provisional; Region: PRK14165 56107002856 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 56107002857 catalytic site [active] 56107002858 putative active site [active] 56107002859 putative substrate binding site [chemical binding]; other site 56107002860 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 56107002861 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 56107002862 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 56107002863 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 56107002864 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107002865 P-loop; other site 56107002866 Magnesium ion binding site [ion binding]; other site 56107002867 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107002868 Magnesium ion binding site [ion binding]; other site 56107002869 isoleucyl-tRNA synthetase; Region: PLN02843 56107002870 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 56107002871 HIGH motif; other site 56107002872 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 56107002873 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 56107002874 active site 56107002875 KMSKS motif; other site 56107002876 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 56107002877 tRNA binding surface [nucleotide binding]; other site 56107002878 anticodon binding site; other site 56107002879 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 56107002880 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 56107002881 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 56107002882 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 56107002883 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 56107002884 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 56107002885 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107002886 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107002887 active site 56107002888 ATP binding site [chemical binding]; other site 56107002889 substrate binding site [chemical binding]; other site 56107002890 activation loop (A-loop); other site 56107002891 PemK-like protein; Region: PemK; pfam02452 56107002892 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 56107002893 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 56107002894 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 56107002895 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 56107002896 putative active site pocket [active] 56107002897 dimerization interface [polypeptide binding]; other site 56107002898 putative catalytic residue [active] 56107002899 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 56107002900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 56107002901 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 56107002902 Peptidase family M50; Region: Peptidase_M50; pfam02163 56107002903 active site 56107002904 putative substrate binding region [chemical binding]; other site 56107002905 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 56107002906 Flavoprotein; Region: Flavoprotein; pfam02441 56107002907 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 56107002908 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 56107002909 Predicted esterase [General function prediction only]; Region: COG0400 56107002910 putative hydrolase; Provisional; Region: PRK11460 56107002911 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 56107002912 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 56107002913 FMN binding site [chemical binding]; other site 56107002914 active site 56107002915 catalytic residues [active] 56107002916 substrate binding site [chemical binding]; other site 56107002917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107002918 Probable transposase; Region: OrfB_IS605; pfam01385 56107002919 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107002920 putative active site [active] 56107002921 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 56107002922 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 56107002923 purine monophosphate binding site [chemical binding]; other site 56107002924 dimer interface [polypeptide binding]; other site 56107002925 putative catalytic residues [active] 56107002926 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 56107002927 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 56107002928 HD domain; Region: HD_3; pfam13023 56107002929 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 56107002930 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 56107002931 catalytic loop [active] 56107002932 iron binding site [ion binding]; other site 56107002933 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 56107002934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107002935 S-adenosylmethionine binding site [chemical binding]; other site 56107002936 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 56107002937 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 56107002938 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 56107002939 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 56107002940 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 56107002941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107002942 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107002943 putative active site [active] 56107002944 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 56107002945 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 56107002946 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 56107002947 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 56107002948 Fasciclin domain; Region: Fasciclin; pfam02469 56107002949 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 56107002950 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 56107002951 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 56107002952 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 56107002953 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 56107002954 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 56107002955 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 56107002956 active site 56107002957 Zn binding site [ion binding]; other site 56107002958 DNA gyrase subunit A; Validated; Region: PRK05560 56107002959 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 56107002960 CAP-like domain; other site 56107002961 active site 56107002962 primary dimer interface [polypeptide binding]; other site 56107002963 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 56107002964 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 56107002965 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 56107002966 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 56107002967 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 56107002968 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 56107002969 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 56107002970 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 56107002971 putative active site [active] 56107002972 catalytic triad [active] 56107002973 putative dimer interface [polypeptide binding]; other site 56107002974 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 56107002975 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 56107002976 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 56107002977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107002978 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107002979 Probable transposase; Region: OrfB_IS605; pfam01385 56107002980 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107002981 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 56107002982 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 56107002983 dimer interface [polypeptide binding]; other site 56107002984 catalytic triad [active] 56107002985 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 56107002986 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 56107002987 active site 56107002988 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 56107002989 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 56107002990 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 56107002991 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 56107002992 phosphopeptide binding site; other site 56107002993 MG2 domain; Region: A2M_N; pfam01835 56107002994 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 56107002995 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 56107002996 Ligand Binding Site [chemical binding]; other site 56107002997 Molecular Tunnel; other site 56107002998 diaminopimelate decarboxylase; Region: lysA; TIGR01048 56107002999 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 56107003000 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 56107003001 catalytic residue [active] 56107003002 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 56107003003 active site 56107003004 metal binding site [ion binding]; metal-binding site 56107003005 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 56107003006 active site 56107003007 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 56107003008 Ligand Binding Site [chemical binding]; other site 56107003009 Molecular Tunnel; other site 56107003010 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 56107003011 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 56107003012 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 56107003013 active site 56107003014 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 56107003015 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 56107003016 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107003017 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107003018 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107003019 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 56107003020 Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346 56107003021 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 56107003022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107003023 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 56107003024 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 56107003025 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 56107003026 nucleotide binding site [chemical binding]; other site 56107003027 NEF interaction site [polypeptide binding]; other site 56107003028 SBD interface [polypeptide binding]; other site 56107003029 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 56107003030 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 56107003031 FMN binding site [chemical binding]; other site 56107003032 active site 56107003033 catalytic residues [active] 56107003034 substrate binding site [chemical binding]; other site 56107003035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107003036 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 56107003037 Probable transposase; Region: OrfB_IS605; pfam01385 56107003038 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107003039 HEAT repeats; Region: HEAT_2; pfam13646 56107003040 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107003041 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107003042 active site 56107003043 ATP binding site [chemical binding]; other site 56107003044 substrate binding site [chemical binding]; other site 56107003045 activation loop (A-loop); other site 56107003046 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107003047 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107003048 structural tetrad; other site 56107003049 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 56107003050 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 56107003051 homodimer interface [polypeptide binding]; other site 56107003052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107003053 catalytic residue [active] 56107003054 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 56107003055 Restriction endonuclease BamHI; Region: BamHI; pfam02923 56107003056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107003057 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 56107003058 DNA methylase; Region: N6_N4_Mtase; pfam01555 56107003059 Helix-turn-helix domain; Region: HTH_17; pfam12728 56107003060 GTP-binding protein YchF; Reviewed; Region: PRK09601 56107003061 YchF GTPase; Region: YchF; cd01900 56107003062 G1 box; other site 56107003063 GTP/Mg2+ binding site [chemical binding]; other site 56107003064 Switch I region; other site 56107003065 G2 box; other site 56107003066 Switch II region; other site 56107003067 G3 box; other site 56107003068 G4 box; other site 56107003069 G5 box; other site 56107003070 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 56107003071 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 56107003072 ligand binding site [chemical binding]; other site 56107003073 active site 56107003074 UGI interface [polypeptide binding]; other site 56107003075 catalytic site [active] 56107003076 Protein of function (DUF2518); Region: DUF2518; pfam10726 56107003077 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 56107003078 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 56107003079 putative active site [active] 56107003080 metal binding site [ion binding]; metal-binding site 56107003081 aspartate aminotransferase; Provisional; Region: PRK05942 56107003082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 56107003083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107003084 homodimer interface [polypeptide binding]; other site 56107003085 catalytic residue [active] 56107003086 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107003087 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 56107003088 PQQ-like domain; Region: PQQ_2; pfam13360 56107003089 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107003090 structural tetrad; other site 56107003091 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107003092 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107003093 active site 56107003094 ATP binding site [chemical binding]; other site 56107003095 substrate binding site [chemical binding]; other site 56107003096 activation loop (A-loop); other site 56107003097 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 56107003098 dimerization interface [polypeptide binding]; other site 56107003099 putative DNA binding site [nucleotide binding]; other site 56107003100 putative Zn2+ binding site [ion binding]; other site 56107003101 PBP superfamily domain; Region: PBP_like_2; cl17296 56107003102 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 56107003103 amphipathic channel; other site 56107003104 Asn-Pro-Ala signature motifs; other site 56107003105 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 56107003106 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 56107003107 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 56107003108 Low molecular weight phosphatase family; Region: LMWPc; cd00115 56107003109 active site 56107003110 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 56107003111 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 56107003112 putative acyl-acceptor binding pocket; other site 56107003113 FAD dependent oxidoreductase; Region: DAO; pfam01266 56107003114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 56107003115 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 56107003116 classical (c) SDRs; Region: SDR_c; cd05233 56107003117 NAD(P) binding site [chemical binding]; other site 56107003118 active site 56107003119 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107003120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107003121 active site 56107003122 phosphorylation site [posttranslational modification] 56107003123 intermolecular recognition site; other site 56107003124 dimerization interface [polypeptide binding]; other site 56107003125 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107003126 DNA binding site [nucleotide binding] 56107003127 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 56107003128 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 56107003129 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 56107003130 catalytic core [active] 56107003131 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107003132 GAF domain; Region: GAF; pfam01590 56107003133 PAS domain S-box; Region: sensory_box; TIGR00229 56107003134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107003135 putative active site [active] 56107003136 heme pocket [chemical binding]; other site 56107003137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107003138 PAS fold; Region: PAS_3; pfam08447 56107003139 putative active site [active] 56107003140 heme pocket [chemical binding]; other site 56107003141 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107003142 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107003143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107003144 dimer interface [polypeptide binding]; other site 56107003145 phosphorylation site [posttranslational modification] 56107003146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107003147 ATP binding site [chemical binding]; other site 56107003148 Mg2+ binding site [ion binding]; other site 56107003149 G-X-G motif; other site 56107003150 Response regulator receiver domain; Region: Response_reg; pfam00072 56107003151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107003152 active site 56107003153 phosphorylation site [posttranslational modification] 56107003154 intermolecular recognition site; other site 56107003155 dimerization interface [polypeptide binding]; other site 56107003156 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107003157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107003158 active site 56107003159 phosphorylation site [posttranslational modification] 56107003160 intermolecular recognition site; other site 56107003161 dimerization interface [polypeptide binding]; other site 56107003162 PAS fold; Region: PAS_4; pfam08448 56107003163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107003164 putative active site [active] 56107003165 heme pocket [chemical binding]; other site 56107003166 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107003167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107003168 putative active site [active] 56107003169 heme pocket [chemical binding]; other site 56107003170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107003171 dimer interface [polypeptide binding]; other site 56107003172 phosphorylation site [posttranslational modification] 56107003173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107003174 ATP binding site [chemical binding]; other site 56107003175 Mg2+ binding site [ion binding]; other site 56107003176 G-X-G motif; other site 56107003177 Response regulator receiver domain; Region: Response_reg; pfam00072 56107003178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107003179 active site 56107003180 phosphorylation site [posttranslational modification] 56107003181 intermolecular recognition site; other site 56107003182 dimerization interface [polypeptide binding]; other site 56107003183 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 56107003184 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107003185 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 56107003186 Walker A/P-loop; other site 56107003187 ATP binding site [chemical binding]; other site 56107003188 Q-loop/lid; other site 56107003189 ABC transporter signature motif; other site 56107003190 Walker B; other site 56107003191 D-loop; other site 56107003192 H-loop/switch region; other site 56107003193 LabA_like proteins; Region: LabA_like; cd06167 56107003194 putative metal binding site [ion binding]; other site 56107003195 short chain dehydrogenase; Provisional; Region: PRK08219 56107003196 classical (c) SDRs; Region: SDR_c; cd05233 56107003197 NAD(P) binding site [chemical binding]; other site 56107003198 active site 56107003199 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 56107003200 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 56107003201 dimer interface [polypeptide binding]; other site 56107003202 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 56107003203 active site 56107003204 Fe binding site [ion binding]; other site 56107003205 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 56107003206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107003207 motif II; other site 56107003208 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 56107003209 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107003210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107003211 active site 56107003212 phosphorylation site [posttranslational modification] 56107003213 intermolecular recognition site; other site 56107003214 dimerization interface [polypeptide binding]; other site 56107003215 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107003216 DNA binding site [nucleotide binding] 56107003217 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 56107003218 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 56107003219 NAD binding site [chemical binding]; other site 56107003220 ligand binding site [chemical binding]; other site 56107003221 catalytic site [active] 56107003222 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 56107003223 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 56107003224 Walker A/P-loop; other site 56107003225 ATP binding site [chemical binding]; other site 56107003226 Q-loop/lid; other site 56107003227 ABC transporter signature motif; other site 56107003228 Walker B; other site 56107003229 D-loop; other site 56107003230 H-loop/switch region; other site 56107003231 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 56107003232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107003233 dimer interface [polypeptide binding]; other site 56107003234 conserved gate region; other site 56107003235 putative PBP binding loops; other site 56107003236 ABC-ATPase subunit interface; other site 56107003237 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 56107003238 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 56107003239 active site 56107003240 dimer interface [polypeptide binding]; other site 56107003241 non-prolyl cis peptide bond; other site 56107003242 insertion regions; other site 56107003243 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 56107003244 dimer interface [polypeptide binding]; other site 56107003245 FMN binding site [chemical binding]; other site 56107003246 NADPH bind site [chemical binding]; other site 56107003247 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 56107003248 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 56107003249 Ferredoxin [Energy production and conversion]; Region: COG1146 56107003250 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 56107003251 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 56107003252 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 56107003253 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107003254 DevC protein; Region: devC; TIGR01185 56107003255 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 56107003256 FtsX-like permease family; Region: FtsX; pfam02687 56107003257 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 56107003258 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 56107003259 Walker A/P-loop; other site 56107003260 ATP binding site [chemical binding]; other site 56107003261 Q-loop/lid; other site 56107003262 ABC transporter signature motif; other site 56107003263 Walker B; other site 56107003264 D-loop; other site 56107003265 H-loop/switch region; other site 56107003266 Predicted permeases [General function prediction only]; Region: COG0679 56107003267 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 56107003268 Peptidase family M23; Region: Peptidase_M23; pfam01551 56107003269 Late competence development protein ComFB; Region: ComFB; pfam10719 56107003270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 56107003271 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 56107003272 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 56107003273 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 56107003274 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 56107003275 DNA binding residues [nucleotide binding] 56107003276 Putative zinc-finger; Region: zf-HC2; pfam13490 56107003277 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 56107003278 putative active site pocket [active] 56107003279 dimerization interface [polypeptide binding]; other site 56107003280 putative catalytic residue [active] 56107003281 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 56107003282 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 56107003283 HIGH motif; other site 56107003284 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 56107003285 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 56107003286 active site 56107003287 KMSKS motif; other site 56107003288 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 56107003289 tRNA binding surface [nucleotide binding]; other site 56107003290 Glyco_18 domain; Region: Glyco_18; smart00636 56107003291 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 56107003292 active site 56107003293 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 56107003294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107003295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107003296 dimer interface [polypeptide binding]; other site 56107003297 phosphorylation site [posttranslational modification] 56107003298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107003299 ATP binding site [chemical binding]; other site 56107003300 Mg2+ binding site [ion binding]; other site 56107003301 G-X-G motif; other site 56107003302 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107003303 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107003304 active site 56107003305 ATP binding site [chemical binding]; other site 56107003306 substrate binding site [chemical binding]; other site 56107003307 activation loop (A-loop); other site 56107003308 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107003309 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107003310 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107003311 glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482 56107003312 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 56107003313 inhibitor-cofactor binding pocket; inhibition site 56107003314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107003315 catalytic residue [active] 56107003316 ChaB; Region: ChaB; cl01887 56107003317 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 56107003318 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 56107003319 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 56107003320 metal binding site [ion binding]; metal-binding site 56107003321 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 56107003322 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 56107003323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107003324 Walker A/P-loop; other site 56107003325 ATP binding site [chemical binding]; other site 56107003326 Q-loop/lid; other site 56107003327 ABC transporter signature motif; other site 56107003328 Walker B; other site 56107003329 D-loop; other site 56107003330 H-loop/switch region; other site 56107003331 ABC-2 type transporter; Region: ABC2_membrane; cl17235 56107003332 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 56107003333 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 56107003334 MarR family; Region: MarR; pfam01047 56107003335 H+ Antiporter protein; Region: 2A0121; TIGR00900 56107003336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107003337 putative substrate translocation pore; other site 56107003338 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 56107003339 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 56107003340 active site 56107003341 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 56107003342 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107003343 substrate binding pocket [chemical binding]; other site 56107003344 membrane-bound complex binding site; other site 56107003345 hinge residues; other site 56107003346 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 56107003347 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 56107003348 active site 56107003349 iron coordination sites [ion binding]; other site 56107003350 substrate binding pocket [chemical binding]; other site 56107003351 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 56107003352 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107003353 substrate binding pocket [chemical binding]; other site 56107003354 membrane-bound complex binding site; other site 56107003355 hinge residues; other site 56107003356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107003357 S-adenosylmethionine binding site [chemical binding]; other site 56107003358 S-layer homology domain; Region: SLH; pfam00395 56107003359 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 56107003360 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 56107003361 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 56107003362 putative NAD(P) binding site [chemical binding]; other site 56107003363 AAA ATPase domain; Region: AAA_16; pfam13191 56107003364 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107003365 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107003366 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107003367 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107003368 Protein of unknown function, DUF488; Region: DUF488; pfam04343 56107003369 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 56107003370 O-Antigen ligase; Region: Wzy_C; pfam04932 56107003371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 56107003372 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 56107003373 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107003374 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107003375 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107003376 active site 56107003377 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 56107003378 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 56107003379 M28 Zn-Peptidases; Region: M28_like_1; cd05640 56107003380 Peptidase family M28; Region: Peptidase_M28; pfam04389 56107003381 metal binding site [ion binding]; metal-binding site 56107003382 molecular chaperone DnaK; Provisional; Region: PRK13410 56107003383 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 56107003384 nucleotide binding site [chemical binding]; other site 56107003385 NEF interaction site [polypeptide binding]; other site 56107003386 SBD interface [polypeptide binding]; other site 56107003387 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 56107003388 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107003389 HSP70 interaction site [polypeptide binding]; other site 56107003390 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 56107003391 substrate binding site [polypeptide binding]; other site 56107003392 dimer interface [polypeptide binding]; other site 56107003393 CHAT domain; Region: CHAT; cl17868 56107003394 AAA ATPase domain; Region: AAA_16; pfam13191 56107003395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107003396 binding surface 56107003397 TPR motif; other site 56107003398 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107003399 TPR repeat; Region: TPR_11; pfam13414 56107003400 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107003401 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107003402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107003403 binding surface 56107003404 TPR motif; other site 56107003405 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107003406 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107003407 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 56107003408 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107003409 putative active site [active] 56107003410 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 56107003411 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107003412 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 56107003413 HSP70 interaction site [polypeptide binding]; other site 56107003414 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 56107003415 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 56107003416 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 56107003417 catalytic residue [active] 56107003418 putative FPP diphosphate binding site; other site 56107003419 putative FPP binding hydrophobic cleft; other site 56107003420 dimer interface [polypeptide binding]; other site 56107003421 putative IPP diphosphate binding site; other site 56107003422 Uncharacterized conserved protein [Function unknown]; Region: COG1624 56107003423 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 56107003424 diaminopimelate decarboxylase; Region: lysA; TIGR01048 56107003425 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 56107003426 active site 56107003427 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 56107003428 substrate binding site [chemical binding]; other site 56107003429 catalytic residues [active] 56107003430 dimer interface [polypeptide binding]; other site 56107003431 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 56107003432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107003433 Coenzyme A binding pocket [chemical binding]; other site 56107003434 Clp protease ATP binding subunit; Region: clpC; CHL00095 56107003435 Clp amino terminal domain; Region: Clp_N; pfam02861 56107003436 Clp amino terminal domain; Region: Clp_N; pfam02861 56107003437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107003438 Walker A motif; other site 56107003439 ATP binding site [chemical binding]; other site 56107003440 Walker B motif; other site 56107003441 arginine finger; other site 56107003442 UvrB/uvrC motif; Region: UVR; pfam02151 56107003443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107003444 Walker A motif; other site 56107003445 ATP binding site [chemical binding]; other site 56107003446 Walker B motif; other site 56107003447 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 56107003448 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 56107003449 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 56107003450 putative active site [active] 56107003451 putative NTP binding site [chemical binding]; other site 56107003452 putative nucleic acid binding site [nucleotide binding]; other site 56107003453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 56107003454 clan AA aspartic protease, AF_0612 family; Region: clan_AA_DTGF; TIGR03698 56107003455 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 56107003456 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 56107003457 nucleotide binding site [chemical binding]; other site 56107003458 putative NEF/HSP70 interaction site [polypeptide binding]; other site 56107003459 SBD interface [polypeptide binding]; other site 56107003460 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 56107003461 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 56107003462 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 56107003463 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 56107003464 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 56107003465 Catalytic site [active] 56107003466 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 56107003467 YcaO-like family; Region: YcaO; pfam02624 56107003468 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 56107003469 Amidohydrolase; Region: Amidohydro_2; pfam04909 56107003470 Protein kinase domain; Region: Pkinase; pfam00069 56107003471 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107003472 active site 56107003473 ATP binding site [chemical binding]; other site 56107003474 substrate binding site [chemical binding]; other site 56107003475 activation loop (A-loop); other site 56107003476 AAA ATPase domain; Region: AAA_16; pfam13191 56107003477 Predicted ATPase [General function prediction only]; Region: COG3899 56107003478 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107003479 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107003480 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 56107003481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 56107003482 active site 56107003483 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 56107003484 Walker A motif; other site 56107003485 ATP binding site [chemical binding]; other site 56107003486 Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476 56107003487 putative active site [active] 56107003488 putative catalytic triad [active] 56107003489 cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895 56107003490 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 56107003491 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 56107003492 Short C-terminal domain; Region: SHOCT; pfam09851 56107003493 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 56107003494 Transglycosylase; Region: Transgly; pfam00912 56107003495 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 56107003496 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 56107003497 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 56107003498 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 56107003499 active site 56107003500 HIGH motif; other site 56107003501 dimer interface [polypeptide binding]; other site 56107003502 KMSKS motif; other site 56107003503 S4 domain; Region: S4; pfam01479 56107003504 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 56107003505 active site 56107003506 dimer interface [polypeptide binding]; other site 56107003507 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 56107003508 Fe-S cluster binding site [ion binding]; other site 56107003509 active site 56107003510 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107003511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107003512 TPR motif; other site 56107003513 binding surface 56107003514 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107003515 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107003516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107003517 binding surface 56107003518 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107003519 TPR motif; other site 56107003520 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107003521 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107003522 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107003523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107003524 S-adenosylmethionine binding site [chemical binding]; other site 56107003525 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 56107003526 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 56107003527 active site 56107003528 trimer interface [polypeptide binding]; other site 56107003529 allosteric site; other site 56107003530 active site lid [active] 56107003531 hexamer (dimer of trimers) interface [polypeptide binding]; other site 56107003532 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 56107003533 Helix-turn-helix domain; Region: HTH_25; pfam13413 56107003534 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 56107003535 Helix-turn-helix domain; Region: HTH_25; pfam13413 56107003536 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 56107003537 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 56107003538 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 56107003539 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 56107003540 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 56107003541 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 56107003542 generic binding surface I; other site 56107003543 generic binding surface II; other site 56107003544 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 56107003545 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 56107003546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107003547 S-adenosylmethionine binding site [chemical binding]; other site 56107003548 O-methyltransferase; Region: Methyltransf_2; pfam00891 56107003549 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 56107003550 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 56107003551 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 56107003552 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 56107003553 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 56107003554 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 56107003555 Walker A/P-loop; other site 56107003556 ATP binding site [chemical binding]; other site 56107003557 Q-loop/lid; other site 56107003558 ABC transporter signature motif; other site 56107003559 Walker B; other site 56107003560 D-loop; other site 56107003561 H-loop/switch region; other site 56107003562 DevC protein; Region: devC; TIGR01185 56107003563 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 56107003564 FtsX-like permease family; Region: FtsX; pfam02687 56107003565 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 56107003566 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107003567 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107003568 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 56107003569 active site 56107003570 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107003571 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107003572 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107003573 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107003574 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 56107003575 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 56107003576 putative NADP binding site [chemical binding]; other site 56107003577 active site 56107003578 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 56107003579 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107003580 active site 56107003581 Acyl transferase domain; Region: Acyl_transf_1; cl08282 56107003582 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 56107003583 FMN binding site [chemical binding]; other site 56107003584 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 56107003585 substrate binding site [chemical binding]; other site 56107003586 putative catalytic residue [active] 56107003587 Alcohol acetyltransferase; Region: AATase; pfam07247 56107003588 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107003589 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 56107003590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107003591 NAD(P) binding site [chemical binding]; other site 56107003592 active site 56107003593 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 56107003594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107003595 NAD(P) binding site [chemical binding]; other site 56107003596 active site 56107003597 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 56107003598 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 56107003599 Walker A/P-loop; other site 56107003600 ATP binding site [chemical binding]; other site 56107003601 Q-loop/lid; other site 56107003602 ABC transporter signature motif; other site 56107003603 Walker B; other site 56107003604 D-loop; other site 56107003605 H-loop/switch region; other site 56107003606 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 56107003607 active site 56107003608 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 56107003609 dimer interface [polypeptide binding]; other site 56107003610 substrate binding site [chemical binding]; other site 56107003611 metal binding site [ion binding]; metal-binding site 56107003612 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 56107003613 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 56107003614 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 56107003615 metal-binding site [ion binding] 56107003616 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 56107003617 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 56107003618 metal-binding site [ion binding] 56107003619 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 56107003620 Soluble P-type ATPase [General function prediction only]; Region: COG4087 56107003621 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 56107003622 DNA binding residues [nucleotide binding] 56107003623 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 56107003624 dimer interface [polypeptide binding]; other site 56107003625 metal binding site [ion binding]; metal-binding site 56107003626 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 56107003627 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 56107003628 [2Fe-2S] cluster binding site [ion binding]; other site 56107003629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107003630 binding surface 56107003631 TPR motif; other site 56107003632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107003633 TPR motif; other site 56107003634 binding surface 56107003635 phosphodiesterase YaeI; Provisional; Region: PRK11340 56107003636 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 56107003637 putative active site [active] 56107003638 putative metal binding site [ion binding]; other site 56107003639 GTP-binding protein Der; Reviewed; Region: PRK00093 56107003640 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 56107003641 G1 box; other site 56107003642 GTP/Mg2+ binding site [chemical binding]; other site 56107003643 Switch I region; other site 56107003644 G2 box; other site 56107003645 Switch II region; other site 56107003646 G3 box; other site 56107003647 G4 box; other site 56107003648 G5 box; other site 56107003649 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 56107003650 G1 box; other site 56107003651 GTP/Mg2+ binding site [chemical binding]; other site 56107003652 Switch I region; other site 56107003653 G2 box; other site 56107003654 G3 box; other site 56107003655 Switch II region; other site 56107003656 G4 box; other site 56107003657 G5 box; other site 56107003658 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 56107003659 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 56107003660 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 56107003661 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 56107003662 catalytic residue [active] 56107003663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 56107003664 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 56107003665 pyrroline-5-carboxylate reductase; Region: PLN02688 56107003666 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 56107003667 Uncharacterized paraquat-inducible protein B [Function unknown]; Region: COG3007 56107003668 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 56107003669 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107003670 ATP binding site [chemical binding]; other site 56107003671 putative Mg++ binding site [ion binding]; other site 56107003672 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107003673 nucleotide binding region [chemical binding]; other site 56107003674 ATP-binding site [chemical binding]; other site 56107003675 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 56107003676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107003677 TPR motif; other site 56107003678 TPR repeat; Region: TPR_11; pfam13414 56107003679 binding surface 56107003680 glycogen branching enzyme; Provisional; Region: PRK05402 56107003681 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 56107003682 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 56107003683 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 56107003684 active site 56107003685 catalytic site [active] 56107003686 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 56107003687 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 56107003688 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 56107003689 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 56107003690 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 56107003691 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 56107003692 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 56107003693 tellurium resistance terB-like protein; Region: terB_like; cd07177 56107003694 metal binding site [ion binding]; metal-binding site 56107003695 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 56107003696 hypothetical protein; Reviewed; Region: PRK12275 56107003697 four helix bundle protein; Region: TIGR02436 56107003698 GTPase CgtA; Reviewed; Region: obgE; PRK12299 56107003699 GTP1/OBG; Region: GTP1_OBG; pfam01018 56107003700 Obg GTPase; Region: Obg; cd01898 56107003701 G1 box; other site 56107003702 GTP/Mg2+ binding site [chemical binding]; other site 56107003703 Switch I region; other site 56107003704 G2 box; other site 56107003705 G3 box; other site 56107003706 Switch II region; other site 56107003707 G4 box; other site 56107003708 G5 box; other site 56107003709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 56107003710 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 56107003711 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 56107003712 catalytic triad [active] 56107003713 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 56107003714 30S subunit binding site; other site 56107003715 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 56107003716 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107003717 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 56107003718 substrate binding pocket [chemical binding]; other site 56107003719 membrane-bound complex binding site; other site 56107003720 hinge residues; other site 56107003721 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 56107003722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107003723 dimer interface [polypeptide binding]; other site 56107003724 conserved gate region; other site 56107003725 putative PBP binding loops; other site 56107003726 ABC-ATPase subunit interface; other site 56107003727 Staphylococcal nuclease homologues; Region: SNc; smart00318 56107003728 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 56107003729 Catalytic site; other site 56107003730 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 56107003731 MoaE interaction surface [polypeptide binding]; other site 56107003732 MoeB interaction surface [polypeptide binding]; other site 56107003733 thiocarboxylated glycine; other site 56107003734 threonine synthase; Validated; Region: PRK07591 56107003735 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 56107003736 homodimer interface [polypeptide binding]; other site 56107003737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107003738 catalytic residue [active] 56107003739 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 56107003740 MoaE interaction surface [polypeptide binding]; other site 56107003741 MoeB interaction surface [polypeptide binding]; other site 56107003742 thiocarboxylated glycine; other site 56107003743 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 56107003744 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 56107003745 tetramer interface [polypeptide binding]; other site 56107003746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107003747 catalytic residue [active] 56107003748 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 56107003749 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 56107003750 diiron binding motif [ion binding]; other site 56107003751 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 56107003752 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 56107003753 catalytic site [active] 56107003754 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 56107003755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 56107003756 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 56107003757 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 56107003758 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 56107003759 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 56107003760 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 56107003761 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 56107003762 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 56107003763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107003764 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107003765 putative active site [active] 56107003766 heme pocket [chemical binding]; other site 56107003767 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107003768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107003769 putative active site [active] 56107003770 heme pocket [chemical binding]; other site 56107003771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107003772 ATP binding site [chemical binding]; other site 56107003773 Mg2+ binding site [ion binding]; other site 56107003774 G-X-G motif; other site 56107003775 Late competence development protein ComFB; Region: ComFB; pfam10719 56107003776 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107003777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 56107003778 putative active site [active] 56107003779 heme pocket [chemical binding]; other site 56107003780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107003781 putative active site [active] 56107003782 heme pocket [chemical binding]; other site 56107003783 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107003784 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107003785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107003786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107003787 ATP binding site [chemical binding]; other site 56107003788 Mg2+ binding site [ion binding]; other site 56107003789 G-X-G motif; other site 56107003790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107003791 dimerization interface [polypeptide binding]; other site 56107003792 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 56107003793 cyclase homology domain; Region: CHD; cd07302 56107003794 nucleotidyl binding site; other site 56107003795 metal binding site [ion binding]; metal-binding site 56107003796 dimer interface [polypeptide binding]; other site 56107003797 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 56107003798 heme-binding site [chemical binding]; other site 56107003799 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 56107003800 Mechanosensitive ion channel; Region: MS_channel; pfam00924 56107003801 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107003802 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107003803 ligand binding site [chemical binding]; other site 56107003804 flexible hinge region; other site 56107003805 PBP superfamily domain; Region: PBP_like_2; cl17296 56107003806 Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; Region: FRQ1; COG5126 56107003807 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 56107003808 Ca2+ binding site [ion binding]; other site 56107003809 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 56107003810 Ca2+ binding site [ion binding]; other site 56107003811 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 56107003812 Ca2+ binding site [ion binding]; other site 56107003813 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 56107003814 NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...; Region: NOX_Duox_like_FAD_NADP; cd06186 56107003815 FAD binding pocket [chemical binding]; other site 56107003816 FAD binding motif [chemical binding]; other site 56107003817 NAD pyrophosphate binding region [chemical binding]; other site 56107003818 beta-alpha-beta stucture motif; other site 56107003819 NAD binding pocket [chemical binding]; other site 56107003820 NADP ribose binding motif [chemical binding]; other site 56107003821 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 56107003822 diaminopimelate epimerase; Region: PLN02536 56107003823 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 56107003824 Sm and related proteins; Region: Sm_like; cl00259 56107003825 heptamer interface [polypeptide binding]; other site 56107003826 Sm1 motif; other site 56107003827 hexamer interface [polypeptide binding]; other site 56107003828 RNA binding site [nucleotide binding]; other site 56107003829 Sm2 motif; other site 56107003830 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 56107003831 putative cation:proton antiport protein; Provisional; Region: PRK10669 56107003832 TrkA-N domain; Region: TrkA_N; pfam02254 56107003833 TrkA-C domain; Region: TrkA_C; pfam02080 56107003834 TrkA-C domain; Region: TrkA_C; pfam02080 56107003835 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 56107003836 YcfA-like protein; Region: YcfA; pfam07927 56107003837 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 56107003838 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 56107003839 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 56107003840 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 56107003841 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107003842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 56107003843 DinB superfamily; Region: DinB_2; pfam12867 56107003844 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 56107003845 catalytic triad [active] 56107003846 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107003847 active site 56107003848 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 56107003849 Leucine-rich repeats; other site 56107003850 Leucine rich repeat; Region: LRR_8; pfam13855 56107003851 Substrate binding site [chemical binding]; other site 56107003852 Leucine rich repeat; Region: LRR_8; pfam13855 56107003853 Leucine rich repeat; Region: LRR_8; pfam13855 56107003854 Leucine rich repeat; Region: LRR_8; pfam13855 56107003855 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 56107003856 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 56107003857 G1 box; other site 56107003858 GTP/Mg2+ binding site [chemical binding]; other site 56107003859 G2 box; other site 56107003860 Switch I region; other site 56107003861 G3 box; other site 56107003862 Switch II region; other site 56107003863 G4 box; other site 56107003864 G5 box; other site 56107003865 CHAT domain; Region: CHAT; pfam12770 56107003866 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 56107003867 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 56107003868 active site 56107003869 catalytic triad [active] 56107003870 WxcM-like, C-terminal; Region: FdtA; pfam05523 56107003871 Cupin domain; Region: Cupin_2; pfam07883 56107003872 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 56107003873 dimer interface [polypeptide binding]; other site 56107003874 substrate binding site [chemical binding]; other site 56107003875 ATP binding site [chemical binding]; other site 56107003876 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 56107003877 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 56107003878 Nitrogen regulatory protein P-II; Region: P-II; smart00938 56107003879 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 56107003880 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107003881 non-specific DNA binding site [nucleotide binding]; other site 56107003882 salt bridge; other site 56107003883 sequence-specific DNA binding site [nucleotide binding]; other site 56107003884 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 56107003885 oligomeric interface; other site 56107003886 putative active site [active] 56107003887 homodimer interface [polypeptide binding]; other site 56107003888 Src Homology 3 domain superfamily; Region: SH3; cl17036 56107003889 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 56107003890 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 56107003891 active site 56107003892 dimerization interface [polypeptide binding]; other site 56107003893 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 56107003894 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 56107003895 active site 56107003896 substrate binding site [chemical binding]; other site 56107003897 metal binding site [ion binding]; metal-binding site 56107003898 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 56107003899 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 56107003900 active site 56107003901 substrate binding site [chemical binding]; other site 56107003902 cosubstrate binding site; other site 56107003903 catalytic site [active] 56107003904 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 56107003905 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 56107003906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107003907 dimer interface [polypeptide binding]; other site 56107003908 conserved gate region; other site 56107003909 putative PBP binding loops; other site 56107003910 ABC-ATPase subunit interface; other site 56107003911 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107003912 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107003913 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107003914 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107003915 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 56107003916 hypothetical protein; Validated; Region: PRK07413 56107003917 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 56107003918 Walker A motif; other site 56107003919 homodimer interface [polypeptide binding]; other site 56107003920 ATP binding site [chemical binding]; other site 56107003921 hydroxycobalamin binding site [chemical binding]; other site 56107003922 Walker B motif; other site 56107003923 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 56107003924 Walker A motif; other site 56107003925 homodimer interface [polypeptide binding]; other site 56107003926 ATP binding site [chemical binding]; other site 56107003927 hydroxycobalamin binding site [chemical binding]; other site 56107003928 Walker B motif; other site 56107003929 oxo-acid-lyase/anthranilate synthase; Region: PLN02889 56107003930 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 56107003931 glutamine binding [chemical binding]; other site 56107003932 catalytic triad [active] 56107003933 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 56107003934 chorismate binding enzyme; Region: Chorismate_bind; cl10555 56107003935 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 56107003936 active site 56107003937 NAD binding site [chemical binding]; other site 56107003938 metal binding site [ion binding]; metal-binding site 56107003939 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 56107003940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107003941 S-adenosylmethionine binding site [chemical binding]; other site 56107003942 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 56107003943 ATP-grasp domain; Region: ATP-grasp_4; cl17255 56107003944 hypothetical protein; Provisional; Region: PRK06849 56107003945 ATP-grasp domain; Region: ATP-grasp_4; cl17255 56107003946 hypothetical protein; Provisional; Region: PRK06849 56107003947 ATP-grasp domain; Region: ATP-grasp_4; cl17255 56107003948 ornithine carbamoyltransferase; Provisional; Region: PRK00779 56107003949 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 56107003950 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 56107003951 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 56107003952 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 56107003953 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 56107003954 Catalytic site [active] 56107003955 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 56107003956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107003957 ATP binding site [chemical binding]; other site 56107003958 putative Mg++ binding site [ion binding]; other site 56107003959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107003960 nucleotide binding region [chemical binding]; other site 56107003961 ATP-binding site [chemical binding]; other site 56107003962 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 56107003963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107003964 Walker A/P-loop; other site 56107003965 ATP binding site [chemical binding]; other site 56107003966 S-layer homology domain; Region: SLH; pfam00395 56107003967 S-layer homology domain; Region: SLH; pfam00395 56107003968 S-layer homology domain; Region: SLH; pfam00395 56107003969 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 56107003970 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 56107003971 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 56107003972 DNA-sulfur modification-associated; Region: DndB; pfam14072 56107003973 DGQHR domain; Region: DGQHR; TIGR03187 56107003974 DNA-sulfur modification-associated; Region: DndB; cl17621 56107003975 hypothetical protein; Provisional; Region: PRK06850 56107003976 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 56107003977 Active Sites [active] 56107003978 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107003979 non-specific DNA binding site [nucleotide binding]; other site 56107003980 salt bridge; other site 56107003981 sequence-specific DNA binding site [nucleotide binding]; other site 56107003982 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 56107003983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107003984 Walker A/P-loop; other site 56107003985 ATP binding site [chemical binding]; other site 56107003986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107003987 ABC transporter signature motif; other site 56107003988 Walker B; other site 56107003989 D-loop; other site 56107003990 H-loop/switch region; other site 56107003991 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 56107003992 AmpG-like permease; Region: 2A0125; TIGR00901 56107003993 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 56107003994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107003995 Coenzyme A binding pocket [chemical binding]; other site 56107003996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107003997 Probable transposase; Region: OrfB_IS605; pfam01385 56107003998 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107003999 HEAT repeats; Region: HEAT_2; pfam13646 56107004000 HEAT repeats; Region: HEAT_2; pfam13646 56107004001 HEAT repeats; Region: HEAT_2; pfam13646 56107004002 Cupin domain; Region: Cupin_2; cl17218 56107004003 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 56107004004 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 56107004005 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 56107004006 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107004007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107004008 active site 56107004009 phosphorylation site [posttranslational modification] 56107004010 intermolecular recognition site; other site 56107004011 dimerization interface [polypeptide binding]; other site 56107004012 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 56107004013 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 56107004014 FOG: CBS domain [General function prediction only]; Region: COG0517 56107004015 PAS domain; Region: PAS_9; pfam13426 56107004016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004017 putative active site [active] 56107004018 heme pocket [chemical binding]; other site 56107004019 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004020 PAS fold; Region: PAS_3; pfam08447 56107004021 putative active site [active] 56107004022 heme pocket [chemical binding]; other site 56107004023 PAS fold; Region: PAS_3; pfam08447 56107004024 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 56107004025 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107004026 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004027 putative active site [active] 56107004028 heme pocket [chemical binding]; other site 56107004029 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107004030 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107004031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004032 putative active site [active] 56107004033 heme pocket [chemical binding]; other site 56107004034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004035 putative active site [active] 56107004036 heme pocket [chemical binding]; other site 56107004037 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107004038 GAF domain; Region: GAF; pfam01590 56107004039 PAS domain S-box; Region: sensory_box; TIGR00229 56107004040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004041 putative active site [active] 56107004042 heme pocket [chemical binding]; other site 56107004043 PAS fold; Region: PAS_4; pfam08448 56107004044 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004045 putative active site [active] 56107004046 heme pocket [chemical binding]; other site 56107004047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004048 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107004049 putative active site [active] 56107004050 heme pocket [chemical binding]; other site 56107004051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004052 putative active site [active] 56107004053 heme pocket [chemical binding]; other site 56107004054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004055 PAS domain; Region: PAS_9; pfam13426 56107004056 putative active site [active] 56107004057 heme pocket [chemical binding]; other site 56107004058 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004059 PAS fold; Region: PAS_3; pfam08447 56107004060 putative active site [active] 56107004061 heme pocket [chemical binding]; other site 56107004062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107004063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107004064 dimer interface [polypeptide binding]; other site 56107004065 phosphorylation site [posttranslational modification] 56107004066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107004067 ATP binding site [chemical binding]; other site 56107004068 Mg2+ binding site [ion binding]; other site 56107004069 G-X-G motif; other site 56107004070 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 56107004071 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 56107004072 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 56107004073 Protein of unknown function (DUF512); Region: DUF512; pfam04459 56107004074 CHAT domain; Region: CHAT; pfam12770 56107004075 NB-ARC domain; Region: NB-ARC; pfam00931 56107004076 Bacitracin resistance protein BacA; Region: BacA; pfam02673 56107004077 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 56107004078 Photosystem II 12 kDa extrinsic protein (PsbU); Region: PsbU; pfam06514 56107004079 L-aspartate oxidase; Provisional; Region: PRK07395 56107004080 L-aspartate oxidase; Provisional; Region: PRK06175 56107004081 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 56107004082 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 56107004083 CHASE2 domain; Region: CHASE2; pfam05226 56107004084 PAS domain S-box; Region: sensory_box; TIGR00229 56107004085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004086 putative active site [active] 56107004087 heme pocket [chemical binding]; other site 56107004088 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 56107004089 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 56107004090 metal binding site [ion binding]; metal-binding site 56107004091 active site 56107004092 I-site; other site 56107004093 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 56107004094 substrate binding site [chemical binding]; other site 56107004095 putative active site [active] 56107004096 redox center [active] 56107004097 Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; Region: PDI_a_family; cd02961 56107004098 catalytic residues [active] 56107004099 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722 56107004100 phosphate binding site [ion binding]; other site 56107004101 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 56107004102 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 56107004103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107004104 FeS/SAM binding site; other site 56107004105 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 56107004106 DEAD-like helicases superfamily; Region: DEXDc; smart00487 56107004107 ATP binding site [chemical binding]; other site 56107004108 Mg++ binding site [ion binding]; other site 56107004109 motif III; other site 56107004110 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107004111 nucleotide binding region [chemical binding]; other site 56107004112 ATP-binding site [chemical binding]; other site 56107004113 Predicted ATPase [General function prediction only]; Region: COG4637 56107004114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107004115 Walker A/P-loop; other site 56107004116 ATP binding site [chemical binding]; other site 56107004117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107004118 Q-loop/lid; other site 56107004119 ABC transporter signature motif; other site 56107004120 Walker B; other site 56107004121 D-loop; other site 56107004122 H-loop/switch region; other site 56107004123 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 56107004124 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 56107004125 active site 56107004126 catalytic tetrad [active] 56107004127 PUCC protein; Region: PUCC; pfam03209 56107004128 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 56107004129 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 56107004130 active site 56107004131 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 56107004132 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 56107004133 putative NAD(P) binding site [chemical binding]; other site 56107004134 catalytic Zn binding site [ion binding]; other site 56107004135 structural Zn binding site [ion binding]; other site 56107004136 chlorophyll synthase, ChlG; Region: ChlG; TIGR02056 56107004137 UbiA prenyltransferase family; Region: UbiA; pfam01040 56107004138 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 56107004139 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 56107004140 P loop; other site 56107004141 Nucleotide binding site [chemical binding]; other site 56107004142 DTAP/Switch II; other site 56107004143 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 56107004144 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107004145 putative active site [active] 56107004146 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 56107004147 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 56107004148 NADP-binding site; other site 56107004149 homotetramer interface [polypeptide binding]; other site 56107004150 substrate binding site [chemical binding]; other site 56107004151 homodimer interface [polypeptide binding]; other site 56107004152 active site 56107004153 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 56107004154 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 56107004155 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 56107004156 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 56107004157 Walker A/P-loop; other site 56107004158 ATP binding site [chemical binding]; other site 56107004159 Q-loop/lid; other site 56107004160 ABC transporter signature motif; other site 56107004161 Walker B; other site 56107004162 D-loop; other site 56107004163 H-loop/switch region; other site 56107004164 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107004165 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 56107004166 Methyltransferase domain; Region: Methyltransf_23; pfam13489 56107004167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107004168 S-adenosylmethionine binding site [chemical binding]; other site 56107004169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 56107004170 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 56107004171 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107004172 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107004173 putative active site [active] 56107004174 pyruvate kinase; Provisional; Region: PRK06354 56107004175 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 56107004176 domain interfaces; other site 56107004177 active site 56107004178 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 56107004179 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 56107004180 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 56107004181 putative di-iron ligands [ion binding]; other site 56107004182 PIN domain; Region: PIN_3; pfam13470 56107004183 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 56107004184 Putative addiction module component; Region: Unstab_antitox; pfam09720 56107004185 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 56107004186 homotrimer interaction site [polypeptide binding]; other site 56107004187 active site 56107004188 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 56107004189 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 56107004190 tandem repeat interface [polypeptide binding]; other site 56107004191 oligomer interface [polypeptide binding]; other site 56107004192 active site residues [active] 56107004193 Permease; Region: Permease; cl00510 56107004194 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 56107004195 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 56107004196 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 56107004197 membrane protein; Provisional; Region: PRK14419 56107004198 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 56107004199 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 56107004200 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 56107004201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107004202 NAD(P) binding site [chemical binding]; other site 56107004203 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 56107004204 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 56107004205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107004206 active site 56107004207 Uncharacterized conserved protein [Function unknown]; Region: COG3791 56107004208 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 56107004209 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107004210 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107004211 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107004212 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107004213 DNA binding residues [nucleotide binding] 56107004214 dimerization interface [polypeptide binding]; other site 56107004215 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 56107004216 WD40 repeats; Region: WD40; smart00320 56107004217 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107004218 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107004219 structural tetrad; other site 56107004220 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107004221 WD40 repeats; Region: WD40; smart00320 56107004222 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107004223 structural tetrad; other site 56107004224 WD domain, G-beta repeat; Region: WD40; pfam00400 56107004225 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 56107004226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107004227 Walker A motif; other site 56107004228 ATP binding site [chemical binding]; other site 56107004229 Walker B motif; other site 56107004230 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 56107004231 RxxxH motif; other site 56107004232 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 56107004233 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 56107004234 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 56107004235 Invertebrate innate immunity transcript family; Region: Innate_immun; pfam12782 56107004236 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 56107004237 MOSC domain; Region: MOSC; pfam03473 56107004238 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 56107004239 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 56107004240 Catalytic site [active] 56107004241 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 56107004242 dihydroorotase; Provisional; Region: PRK07575 56107004243 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 56107004244 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 56107004245 active site 56107004246 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 56107004247 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 56107004248 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 56107004249 phosphate binding site [ion binding]; other site 56107004250 putative substrate binding pocket [chemical binding]; other site 56107004251 dimer interface [polypeptide binding]; other site 56107004252 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 56107004253 active site 56107004254 putative DNA-binding cleft [nucleotide binding]; other site 56107004255 dimer interface [polypeptide binding]; other site 56107004256 Protein of unknown function DUF45; Region: DUF45; pfam01863 56107004257 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 56107004258 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 56107004259 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 56107004260 Moco binding site; other site 56107004261 metal coordination site [ion binding]; other site 56107004262 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 56107004263 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 56107004264 active site 56107004265 dimer interface [polypeptide binding]; other site 56107004266 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 56107004267 active site 56107004268 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 56107004269 Domain of unknown function DUF20; Region: UPF0118; pfam01594 56107004270 Nuclease-related domain; Region: NERD; pfam08378 56107004271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107004272 AAA domain; Region: AAA_21; pfam13304 56107004273 Walker A/P-loop; other site 56107004274 ATP binding site [chemical binding]; other site 56107004275 Clp protease ATP binding subunit; Region: clpC; CHL00095 56107004276 Clp amino terminal domain; Region: Clp_N; pfam02861 56107004277 Clp amino terminal domain; Region: Clp_N; pfam02861 56107004278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107004279 Walker A motif; other site 56107004280 ATP binding site [chemical binding]; other site 56107004281 Walker B motif; other site 56107004282 arginine finger; other site 56107004283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107004284 Walker A motif; other site 56107004285 ATP binding site [chemical binding]; other site 56107004286 Walker B motif; other site 56107004287 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 56107004288 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 56107004289 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 56107004290 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 56107004291 CHAT domain; Region: CHAT; cl17868 56107004292 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 56107004293 CHASE2 domain; Region: CHASE2; pfam05226 56107004294 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 56107004295 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107004296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107004297 TPR motif; other site 56107004298 binding surface 56107004299 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107004300 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107004301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107004302 binding surface 56107004303 TPR motif; other site 56107004304 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 56107004305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107004306 TPR motif; other site 56107004307 binding surface 56107004308 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107004309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107004310 binding surface 56107004311 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107004312 TPR motif; other site 56107004313 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107004314 CHAT domain; Region: CHAT; pfam12770 56107004315 hydrolase, alpha/beta fold family protein; Region: PLN02824 56107004316 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 56107004317 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 56107004318 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 56107004319 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 56107004320 shikimate binding site; other site 56107004321 NAD(P) binding site [chemical binding]; other site 56107004322 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 56107004323 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 56107004324 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 56107004325 CoA binding domain; Region: CoA_binding; smart00881 56107004326 CoA-ligase; Region: Ligase_CoA; pfam00549 56107004327 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107004328 putative active site [active] 56107004329 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 56107004330 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107004331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107004332 binding surface 56107004333 TPR motif; other site 56107004334 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107004335 PAS domain S-box; Region: sensory_box; TIGR00229 56107004336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004337 putative active site [active] 56107004338 heme pocket [chemical binding]; other site 56107004339 hypothetical protein; Provisional; Region: PRK13560 56107004340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004341 putative active site [active] 56107004342 heme pocket [chemical binding]; other site 56107004343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004344 putative active site [active] 56107004345 heme pocket [chemical binding]; other site 56107004346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004347 putative active site [active] 56107004348 heme pocket [chemical binding]; other site 56107004349 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107004350 putative active site [active] 56107004351 heme pocket [chemical binding]; other site 56107004352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107004353 dimer interface [polypeptide binding]; other site 56107004354 phosphorylation site [posttranslational modification] 56107004355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107004356 ATP binding site [chemical binding]; other site 56107004357 Mg2+ binding site [ion binding]; other site 56107004358 G-X-G motif; other site 56107004359 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107004360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107004361 active site 56107004362 phosphorylation site [posttranslational modification] 56107004363 intermolecular recognition site; other site 56107004364 dimerization interface [polypeptide binding]; other site 56107004365 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 56107004366 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107004367 ATP binding site [chemical binding]; other site 56107004368 putative Mg++ binding site [ion binding]; other site 56107004369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107004370 nucleotide binding region [chemical binding]; other site 56107004371 ATP-binding site [chemical binding]; other site 56107004372 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 56107004373 Protein of unknown function (DUF790); Region: DUF790; pfam05626 56107004374 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 56107004375 Fasciclin domain; Region: Fasciclin; pfam02469 56107004376 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 56107004377 catalytic core [active] 56107004378 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 56107004379 catalytic core [active] 56107004380 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 56107004381 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 56107004382 Walker A motif; other site 56107004383 ATP binding site [chemical binding]; other site 56107004384 Walker B motif; other site 56107004385 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 56107004386 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 56107004387 active site 56107004388 homodimer interface [polypeptide binding]; other site 56107004389 glycogen synthase; Provisional; Region: glgA; PRK00654 56107004390 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 56107004391 ADP-binding pocket [chemical binding]; other site 56107004392 homodimer interface [polypeptide binding]; other site 56107004393 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 56107004394 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 56107004395 domain interfaces; other site 56107004396 active site 56107004397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 56107004398 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 56107004399 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 56107004400 S-adenosylmethionine synthetase; Validated; Region: PRK05250 56107004401 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 56107004402 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 56107004403 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 56107004404 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 56107004405 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 56107004406 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 56107004407 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 56107004408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107004409 motif II; other site 56107004410 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 56107004411 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 56107004412 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 56107004413 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 56107004414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107004415 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107004416 Probable transposase; Region: OrfB_IS605; pfam01385 56107004417 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107004418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 56107004419 active site 56107004420 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 56107004421 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 56107004422 putative ADP-binding pocket [chemical binding]; other site 56107004423 Putative phosphatase (DUF442); Region: DUF442; cl17385 56107004424 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 56107004425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107004426 Coenzyme A binding pocket [chemical binding]; other site 56107004427 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 56107004428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107004429 Coenzyme A binding pocket [chemical binding]; other site 56107004430 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 56107004431 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 56107004432 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 56107004433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 56107004434 catalytic residue [active] 56107004435 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 56107004436 Cytochrome P450; Region: p450; pfam00067 56107004437 Predicted integral membrane protein [Function unknown]; Region: COG5652 56107004438 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107004439 putative active site [active] 56107004440 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 56107004441 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 56107004442 motif 1; other site 56107004443 active site 56107004444 motif 2; other site 56107004445 motif 3; other site 56107004446 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 56107004447 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 56107004448 metal-binding site [ion binding] 56107004449 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 56107004450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 56107004451 metal binding site [ion binding]; metal-binding site 56107004452 active site 56107004453 I-site; other site 56107004454 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 56107004455 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 56107004456 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 56107004457 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 56107004458 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 56107004459 Penicillin amidase; Region: Penicil_amidase; pfam01804 56107004460 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 56107004461 active site 56107004462 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 56107004463 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 56107004464 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 56107004465 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 56107004466 AMIN domain; Region: AMIN; pfam11741 56107004467 AMIN domain; Region: AMIN; pfam11741 56107004468 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 56107004469 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 56107004470 N-terminal plug; other site 56107004471 ligand-binding site [chemical binding]; other site 56107004472 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 56107004473 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 56107004474 acyl-activating enzyme (AAE) consensus motif; other site 56107004475 active site 56107004476 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107004477 Condensation domain; Region: Condensation; pfam00668 56107004478 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107004479 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107004480 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107004481 acyl-activating enzyme (AAE) consensus motif; other site 56107004482 AMP binding site [chemical binding]; other site 56107004483 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107004484 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107004485 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 56107004486 active site 56107004487 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107004488 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107004489 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 56107004490 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 56107004491 putative NADP binding site [chemical binding]; other site 56107004492 active site 56107004493 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107004494 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 56107004495 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 56107004496 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 56107004497 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 56107004498 homodimer interface [polypeptide binding]; other site 56107004499 active site 56107004500 TDP-binding site; other site 56107004501 acceptor substrate-binding pocket; other site 56107004502 Condensation domain; Region: Condensation; pfam00668 56107004503 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107004504 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107004505 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 56107004506 Condensation domain; Region: Condensation; pfam00668 56107004507 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107004508 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 56107004509 acyl-activating enzyme (AAE) consensus motif; other site 56107004510 AMP binding site [chemical binding]; other site 56107004511 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107004512 Condensation domain; Region: Condensation; pfam00668 56107004513 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107004514 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107004515 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 56107004516 Condensation domain; Region: Condensation; pfam00668 56107004517 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107004518 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 56107004519 acyl-activating enzyme (AAE) consensus motif; other site 56107004520 AMP binding site [chemical binding]; other site 56107004521 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107004522 Condensation domain; Region: Condensation; pfam00668 56107004523 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107004524 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 56107004525 Condensation domain; Region: Condensation; pfam00668 56107004526 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107004527 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 56107004528 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 56107004529 inhibitor-cofactor binding pocket; inhibition site 56107004530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107004531 catalytic residue [active] 56107004532 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107004533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107004534 S-adenosylmethionine binding site [chemical binding]; other site 56107004535 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107004536 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107004537 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 56107004538 acyl-activating enzyme (AAE) consensus motif; other site 56107004539 AMP binding site [chemical binding]; other site 56107004540 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107004541 Condensation domain; Region: Condensation; pfam00668 56107004542 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107004543 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 56107004544 Condensation domain; Region: Condensation; pfam00668 56107004545 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107004546 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107004547 acyl-activating enzyme (AAE) consensus motif; other site 56107004548 AMP binding site [chemical binding]; other site 56107004549 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107004550 Condensation domain; Region: Condensation; pfam00668 56107004551 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107004552 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 56107004553 Condensation domain; Region: Condensation; pfam00668 56107004554 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107004555 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107004556 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107004557 acyl-activating enzyme (AAE) consensus motif; other site 56107004558 AMP binding site [chemical binding]; other site 56107004559 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107004560 Condensation domain; Region: Condensation; pfam00668 56107004561 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107004562 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107004563 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 56107004564 acyl-activating enzyme (AAE) consensus motif; other site 56107004565 AMP binding site [chemical binding]; other site 56107004566 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107004567 thioester reductase domain; Region: Thioester-redct; TIGR01746 56107004568 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 56107004569 putative NAD(P) binding site [chemical binding]; other site 56107004570 active site 56107004571 putative substrate binding site [chemical binding]; other site 56107004572 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 56107004573 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 56107004574 active site 56107004575 catalytic tetrad [active] 56107004576 Cupin-like domain; Region: Cupin_8; pfam13621 56107004577 H+ Antiporter protein; Region: 2A0121; TIGR00900 56107004578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107004579 putative substrate translocation pore; other site 56107004580 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 56107004581 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 56107004582 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 56107004583 putative active site [active] 56107004584 putative substrate binding site [chemical binding]; other site 56107004585 putative cosubstrate binding site; other site 56107004586 catalytic site [active] 56107004587 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 56107004588 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 56107004589 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 56107004590 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 56107004591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107004592 Walker A/P-loop; other site 56107004593 ATP binding site [chemical binding]; other site 56107004594 Q-loop/lid; other site 56107004595 ABC transporter signature motif; other site 56107004596 Walker B; other site 56107004597 D-loop; other site 56107004598 H-loop/switch region; other site 56107004599 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 56107004600 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 56107004601 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 56107004602 PLD-like domain; Region: PLDc_2; pfam13091 56107004603 putative homodimer interface [polypeptide binding]; other site 56107004604 putative active site [active] 56107004605 catalytic site [active] 56107004606 DEAD-like helicases superfamily; Region: DEXDc; smart00487 56107004607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 56107004608 ATP binding site [chemical binding]; other site 56107004609 putative Mg++ binding site [ion binding]; other site 56107004610 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 56107004611 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107004612 nucleotide binding region [chemical binding]; other site 56107004613 ATP-binding site [chemical binding]; other site 56107004614 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 56107004615 S-layer homology domain; Region: SLH; pfam00395 56107004616 S-layer homology domain; Region: SLH; pfam00395 56107004617 S-layer homology domain; Region: SLH; pfam00395 56107004618 S-layer homology domain; Region: SLH; pfam00395 56107004619 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 56107004620 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 56107004621 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 56107004622 catalytic site [active] 56107004623 active site 56107004624 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 56107004625 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 56107004626 conserved cys residue [active] 56107004627 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 56107004628 conserved cys residue [active] 56107004629 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 56107004630 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 56107004631 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 56107004632 thiamine phosphate binding site [chemical binding]; other site 56107004633 active site 56107004634 pyrophosphate binding site [ion binding]; other site 56107004635 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 56107004636 thiS-thiF/thiG interaction site; other site 56107004637 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107004638 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 56107004639 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 56107004640 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107004641 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107004642 active site 56107004643 ATP binding site [chemical binding]; other site 56107004644 substrate binding site [chemical binding]; other site 56107004645 activation loop (A-loop); other site 56107004646 Uncharacterized conserved protein [Function unknown]; Region: COG1262 56107004647 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 56107004648 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 56107004649 Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816 56107004650 substrate binding site [chemical binding]; other site 56107004651 homodimer interface [polypeptide binding]; other site 56107004652 heme binding site [chemical binding]; other site 56107004653 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 56107004654 heme binding pocket [chemical binding]; other site 56107004655 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 56107004656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107004657 dimer interface [polypeptide binding]; other site 56107004658 conserved gate region; other site 56107004659 putative PBP binding loops; other site 56107004660 ABC-ATPase subunit interface; other site 56107004661 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 56107004662 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107004663 putative ADP-binding pocket [chemical binding]; other site 56107004664 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 56107004665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107004666 NAD(P) binding site [chemical binding]; other site 56107004667 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 56107004668 active site 56107004669 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 56107004670 Leucine-rich repeats; other site 56107004671 Substrate binding site [chemical binding]; other site 56107004672 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 56107004673 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 56107004674 active site 56107004675 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 56107004676 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 56107004677 metal binding site [ion binding]; metal-binding site 56107004678 active site 56107004679 I-site; other site 56107004680 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 56107004681 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107004682 putative active site [active] 56107004683 Protein of unknown function DUF262; Region: DUF262; pfam03235 56107004684 Protein of unknown function DUF262; Region: DUF262; pfam03235 56107004685 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 56107004686 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 56107004687 hypothetical protein; Provisional; Region: PRK07236 56107004688 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 56107004689 agmatinase; Region: agmatinase; TIGR01230 56107004690 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 56107004691 putative active site [active] 56107004692 Mn binding site [ion binding]; other site 56107004693 hypothetical protein; Provisional; Region: PRK05421 56107004694 putative catalytic site [active] 56107004695 putative metal binding site [ion binding]; other site 56107004696 putative phosphate binding site [ion binding]; other site 56107004697 putative catalytic site [active] 56107004698 putative phosphate binding site [ion binding]; other site 56107004699 putative metal binding site [ion binding]; other site 56107004700 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 56107004701 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 56107004702 putative active site [active] 56107004703 catalytic site [active] 56107004704 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 56107004705 putative active site [active] 56107004706 catalytic site [active] 56107004707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107004708 AAA domain; Region: AAA_21; pfam13304 56107004709 Walker A/P-loop; other site 56107004710 ATP binding site [chemical binding]; other site 56107004711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107004712 ABC transporter signature motif; other site 56107004713 Walker B; other site 56107004714 D-loop; other site 56107004715 H-loop/switch region; other site 56107004716 threonine dehydratase; Reviewed; Region: PRK09224 56107004717 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 56107004718 tetramer interface [polypeptide binding]; other site 56107004719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107004720 catalytic residue [active] 56107004721 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 56107004722 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 56107004723 putative Ile/Val binding site [chemical binding]; other site 56107004724 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 56107004725 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 56107004726 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 56107004727 RNA/DNA hybrid binding site [nucleotide binding]; other site 56107004728 active site 56107004729 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 56107004730 active site 56107004731 Predicted membrane protein [Function unknown]; Region: COG2324 56107004732 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 56107004733 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 56107004734 putative substrate binding pocket [chemical binding]; other site 56107004735 catalytic triad [active] 56107004736 AB domain interface; other site 56107004737 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 56107004738 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 56107004739 putative active site [active] 56107004740 oxyanion strand; other site 56107004741 catalytic triad [active] 56107004742 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 56107004743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107004744 S-adenosylmethionine binding site [chemical binding]; other site 56107004745 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 56107004746 Cytochrome c; Region: Cytochrom_C; pfam00034 56107004747 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 56107004748 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 56107004749 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 56107004750 active site 56107004751 hydrophilic channel; other site 56107004752 dimerization interface [polypeptide binding]; other site 56107004753 catalytic residues [active] 56107004754 active site lid [active] 56107004755 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107004756 putative active site [active] 56107004757 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107004758 putative active site [active] 56107004759 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 56107004760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107004761 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107004762 Probable transposase; Region: OrfB_IS605; pfam01385 56107004763 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107004764 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 56107004765 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107004766 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 56107004767 Walker A/P-loop; other site 56107004768 ATP binding site [chemical binding]; other site 56107004769 Q-loop/lid; other site 56107004770 ABC transporter signature motif; other site 56107004771 Walker B; other site 56107004772 D-loop; other site 56107004773 H-loop/switch region; other site 56107004774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107004775 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107004776 Probable transposase; Region: OrfB_IS605; pfam01385 56107004777 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107004778 Divergent PAP2 family; Region: DUF212; pfam02681 56107004779 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 56107004780 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 56107004781 substrate binding pocket [chemical binding]; other site 56107004782 chain length determination region; other site 56107004783 substrate-Mg2+ binding site; other site 56107004784 catalytic residues [active] 56107004785 aspartate-rich region 1; other site 56107004786 active site lid residues [active] 56107004787 aspartate-rich region 2; other site 56107004788 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 56107004789 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 56107004790 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 56107004791 homodimer interface [polypeptide binding]; other site 56107004792 NADP binding site [chemical binding]; other site 56107004793 substrate binding site [chemical binding]; other site 56107004794 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 56107004795 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 56107004796 nudix motif; other site 56107004797 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 56107004798 Domain of unknown function DUF20; Region: UPF0118; pfam01594 56107004799 Predicted ATPase [General function prediction only]; Region: COG4637 56107004800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107004801 Walker A/P-loop; other site 56107004802 ATP binding site [chemical binding]; other site 56107004803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107004804 AAA domain; Region: AAA_21; pfam13304 56107004805 Walker A/P-loop; other site 56107004806 ATP binding site [chemical binding]; other site 56107004807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107004808 ABC transporter signature motif; other site 56107004809 Walker B; other site 56107004810 D-loop; other site 56107004811 H-loop/switch region; other site 56107004812 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 56107004813 MutS domain I; Region: MutS_I; pfam01624 56107004814 MutS domain II; Region: MutS_II; pfam05188 56107004815 MutS domain III; Region: MutS_III; pfam05192 56107004816 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 56107004817 Walker A/P-loop; other site 56107004818 ATP binding site [chemical binding]; other site 56107004819 Q-loop/lid; other site 56107004820 ABC transporter signature motif; other site 56107004821 Walker B; other site 56107004822 D-loop; other site 56107004823 H-loop/switch region; other site 56107004824 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 56107004825 putative active site [active] 56107004826 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 56107004827 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107004828 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107004829 active site 56107004830 ATP binding site [chemical binding]; other site 56107004831 substrate binding site [chemical binding]; other site 56107004832 activation loop (A-loop); other site 56107004833 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107004834 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107004835 active site 56107004836 ATP binding site [chemical binding]; other site 56107004837 substrate binding site [chemical binding]; other site 56107004838 activation loop (A-loop); other site 56107004839 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107004840 AMP-binding enzyme; Region: AMP-binding; pfam00501 56107004841 acyl-activating enzyme (AAE) consensus motif; other site 56107004842 AMP binding site [chemical binding]; other site 56107004843 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107004844 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 56107004845 Bacterial SH3 domain homologues; Region: SH3b; smart00287 56107004846 PEP-CTERM family integral membrane protein; Region: PEP_integral; TIGR02921 56107004847 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 56107004848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107004849 binding surface 56107004850 TPR repeat; Region: TPR_11; pfam13414 56107004851 TPR motif; other site 56107004852 TPR repeat; Region: TPR_11; pfam13414 56107004853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107004854 binding surface 56107004855 TPR motif; other site 56107004856 TPR repeat; Region: TPR_11; pfam13414 56107004857 TPR repeat; Region: TPR_11; pfam13414 56107004858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107004859 binding surface 56107004860 TPR motif; other site 56107004861 TPR repeat; Region: TPR_11; pfam13414 56107004862 Uncharacterized ACR (DUF711); Region: DUF711; pfam05167 56107004863 Biofilm formation and stress response factor; Region: BsmA; cl01794 56107004864 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107004865 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107004866 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 56107004867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 56107004868 metal binding site [ion binding]; metal-binding site 56107004869 active site 56107004870 I-site; other site 56107004871 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 56107004872 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 56107004873 ATP-binding site [chemical binding]; other site 56107004874 Gluconate-6-phosphate binding site [chemical binding]; other site 56107004875 Shikimate kinase; Region: SKI; pfam01202 56107004876 HipA-like C-terminal domain; Region: HipA_C; pfam07804 56107004877 HipA N-terminal domain; Region: Couple_hipA; cl11853 56107004878 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 56107004879 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 56107004880 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 56107004881 putative substrate binding site [chemical binding]; other site 56107004882 putative ATP binding site [chemical binding]; other site 56107004883 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107004884 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107004885 DNA binding residues [nucleotide binding] 56107004886 dimerization interface [polypeptide binding]; other site 56107004887 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107004888 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 56107004889 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 56107004890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107004891 NAD(P) binding site [chemical binding]; other site 56107004892 Protein kinase domain; Region: Pkinase; pfam00069 56107004893 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107004894 active site 56107004895 ATP binding site [chemical binding]; other site 56107004896 substrate binding site [chemical binding]; other site 56107004897 activation loop (A-loop); other site 56107004898 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 56107004899 Predicted AdoMet-dependent methyltransferase; Region: AdoMet_MTase; pfam07757 56107004900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107004901 S-adenosylmethionine binding site [chemical binding]; other site 56107004902 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 56107004903 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 56107004904 active site 56107004905 zinc binding site [ion binding]; other site 56107004906 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 56107004907 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 56107004908 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 56107004909 methionine sulfoxide reductase A; Provisional; Region: PRK00058 56107004910 proton extrusion protein PcxA; Provisional; Region: PRK02507 56107004911 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 56107004912 MltA specific insert domain; Region: MltA; pfam03562 56107004913 3D domain; Region: 3D; pfam06725 56107004914 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 56107004915 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 56107004916 NodB motif; other site 56107004917 active site 56107004918 catalytic site [active] 56107004919 metal binding site [ion binding]; metal-binding site 56107004920 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 56107004921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 56107004922 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107004923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107004924 binding surface 56107004925 TPR motif; other site 56107004926 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107004927 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107004928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107004929 binding surface 56107004930 TPR motif; other site 56107004931 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107004932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 56107004933 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 56107004934 CHAT domain; Region: CHAT; cl17868 56107004935 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 56107004936 CHASE2 domain; Region: CHASE2; pfam05226 56107004937 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 56107004938 putative acyl transferase; Provisional; Region: PRK10502 56107004939 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 56107004940 putative trimer interface [polypeptide binding]; other site 56107004941 putative active site [active] 56107004942 putative substrate binding site [chemical binding]; other site 56107004943 putative CoA binding site [chemical binding]; other site 56107004944 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107004945 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 56107004946 putative metal binding site; other site 56107004947 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107004948 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107004949 active site 56107004950 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 56107004951 homotrimer interface [polypeptide binding]; other site 56107004952 Walker A motif; other site 56107004953 GTP binding site [chemical binding]; other site 56107004954 Walker B motif; other site 56107004955 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 56107004956 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 56107004957 putative active site [active] 56107004958 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107004959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107004960 Walker A/P-loop; other site 56107004961 ATP binding site [chemical binding]; other site 56107004962 Q-loop/lid; other site 56107004963 ABC transporter signature motif; other site 56107004964 Walker B; other site 56107004965 D-loop; other site 56107004966 H-loop/switch region; other site 56107004967 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 56107004968 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 56107004969 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107004970 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107004971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107004972 active site 56107004973 phosphorylation site [posttranslational modification] 56107004974 intermolecular recognition site; other site 56107004975 dimerization interface [polypeptide binding]; other site 56107004976 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 56107004977 CHASE2 domain; Region: CHASE2; pfam05226 56107004978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 56107004979 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 56107004980 ribonuclease Z; Region: RNase_Z; TIGR02651 56107004981 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 56107004982 Chain length determinant protein; Region: Wzz; pfam02706 56107004983 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 56107004984 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 56107004985 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 56107004986 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107004987 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 56107004988 Walker A/P-loop; other site 56107004989 ATP binding site [chemical binding]; other site 56107004990 Q-loop/lid; other site 56107004991 ABC transporter signature motif; other site 56107004992 Walker B; other site 56107004993 D-loop; other site 56107004994 H-loop/switch region; other site 56107004995 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 56107004996 HflK protein; Region: hflK; TIGR01933 56107004997 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 56107004998 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 56107004999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107005000 Walker A/P-loop; other site 56107005001 ATP binding site [chemical binding]; other site 56107005002 Q-loop/lid; other site 56107005003 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 56107005004 ABC transporter signature motif; other site 56107005005 Walker B; other site 56107005006 D-loop; other site 56107005007 ABC transporter; Region: ABC_tran_2; pfam12848 56107005008 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 56107005009 Phytochelatin synthase; Region: Phytochelatin; pfam05023 56107005010 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 56107005011 Predicted ATPase [General function prediction only]; Region: COG4637 56107005012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107005013 Walker A/P-loop; other site 56107005014 ATP binding site [chemical binding]; other site 56107005015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107005016 Walker B; other site 56107005017 D-loop; other site 56107005018 H-loop/switch region; other site 56107005019 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 56107005020 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 56107005021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 56107005022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 56107005023 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 56107005024 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 56107005025 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 56107005026 active site 56107005027 catalytic tetrad [active] 56107005028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107005029 Probable transposase; Region: OrfB_IS605; pfam01385 56107005030 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 56107005031 mce related protein; Region: MCE; pfam02470 56107005032 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 56107005033 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 56107005034 Walker A/P-loop; other site 56107005035 ATP binding site [chemical binding]; other site 56107005036 Q-loop/lid; other site 56107005037 ABC transporter signature motif; other site 56107005038 Walker B; other site 56107005039 D-loop; other site 56107005040 H-loop/switch region; other site 56107005041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107005042 carotene isomerase; Region: carot_isom; TIGR02730 56107005043 YcfA-like protein; Region: YcfA; pfam07927 56107005044 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 56107005045 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 56107005046 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 56107005047 cofactor binding site; other site 56107005048 DNA binding site [nucleotide binding] 56107005049 substrate interaction site [chemical binding]; other site 56107005050 dihydroorotase; Provisional; Region: PRK07369 56107005051 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 56107005052 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 56107005053 active site 56107005054 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 56107005055 tetramer interface [polypeptide binding]; other site 56107005056 dimer interface [polypeptide binding]; other site 56107005057 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 56107005058 putative lipid kinase; Reviewed; Region: PRK00861 56107005059 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 56107005060 PEGA domain; Region: PEGA; pfam08308 56107005061 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 56107005062 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 56107005063 active site 56107005064 metal binding site [ion binding]; metal-binding site 56107005065 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 56107005066 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 56107005067 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107005068 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107005069 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107005070 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107005071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107005072 TPR repeat; Region: TPR_11; pfam13414 56107005073 TPR motif; other site 56107005074 binding surface 56107005075 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 56107005076 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 56107005077 Cytochrome P450; Region: p450; pfam00067 56107005078 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 56107005079 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 56107005080 tyrosine decarboxylase; Region: PLN02880 56107005081 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 56107005082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107005083 catalytic residue [active] 56107005084 glutamyl-tRNA(Gln) amidotransferase subunit E; Validated; Region: PRK04028 56107005085 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107005086 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107005087 active site 56107005088 ATP binding site [chemical binding]; other site 56107005089 substrate binding site [chemical binding]; other site 56107005090 activation loop (A-loop); other site 56107005091 AAA ATPase domain; Region: AAA_16; pfam13191 56107005092 Predicted ATPase [General function prediction only]; Region: COG3899 56107005093 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107005094 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107005095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107005096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107005097 dimer interface [polypeptide binding]; other site 56107005098 phosphorylation site [posttranslational modification] 56107005099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005100 ATP binding site [chemical binding]; other site 56107005101 Mg2+ binding site [ion binding]; other site 56107005102 G-X-G motif; other site 56107005103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107005104 Coenzyme A binding pocket [chemical binding]; other site 56107005105 amidase; Provisional; Region: PRK09201 56107005106 Amidase; Region: Amidase; cl11426 56107005107 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 56107005108 Protein of unknown function (DUF952); Region: DUF952; cl01393 56107005109 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 56107005110 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 56107005111 catalytic residues [active] 56107005112 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 56107005113 glutaminase; Provisional; Region: PRK00971 56107005114 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 56107005115 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 56107005116 Transposase IS200 like; Region: Y1_Tnp; cl00848 56107005117 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 56107005118 active site 56107005119 catalytic triad [active] 56107005120 oxyanion hole [active] 56107005121 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 56107005122 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 56107005123 Ligand Binding Site [chemical binding]; other site 56107005124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107005125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107005126 dimer interface [polypeptide binding]; other site 56107005127 phosphorylation site [posttranslational modification] 56107005128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005129 ATP binding site [chemical binding]; other site 56107005130 Mg2+ binding site [ion binding]; other site 56107005131 G-X-G motif; other site 56107005132 Response regulator receiver domain; Region: Response_reg; pfam00072 56107005133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005134 active site 56107005135 phosphorylation site [posttranslational modification] 56107005136 intermolecular recognition site; other site 56107005137 dimerization interface [polypeptide binding]; other site 56107005138 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 56107005139 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 56107005140 TM-ABC transporter signature motif; other site 56107005141 PsaX family; Region: PsaX; pfam08078 56107005142 lipoyl synthase; Provisional; Region: PRK12928 56107005143 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107005144 FeS/SAM binding site; other site 56107005145 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107005146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005147 active site 56107005148 phosphorylation site [posttranslational modification] 56107005149 intermolecular recognition site; other site 56107005150 dimerization interface [polypeptide binding]; other site 56107005151 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 56107005152 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107005153 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107005154 structural tetrad; other site 56107005155 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 56107005156 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 56107005157 tetrameric interface [polypeptide binding]; other site 56107005158 NAD binding site [chemical binding]; other site 56107005159 catalytic residues [active] 56107005160 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107005161 putative active site [active] 56107005162 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 56107005163 arginine-tRNA ligase; Region: PLN02286 56107005164 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 56107005165 active site 56107005166 HIGH motif; other site 56107005167 KMSK motif region; other site 56107005168 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 56107005169 tRNA binding surface [nucleotide binding]; other site 56107005170 anticodon binding site; other site 56107005171 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 56107005172 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 56107005173 putative active site [active] 56107005174 putative metal binding site [ion binding]; other site 56107005175 quinolinate synthetase; Provisional; Region: PRK09375 56107005176 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 56107005177 dimer interface [polypeptide binding]; other site 56107005178 motif 1; other site 56107005179 active site 56107005180 motif 2; other site 56107005181 motif 3; other site 56107005182 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 56107005183 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 56107005184 Competence protein; Region: Competence; pfam03772 56107005185 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 56107005186 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 56107005187 flavoprotein, HI0933 family; Region: TIGR00275 56107005188 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 56107005189 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 56107005190 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 56107005191 trimer interface [polypeptide binding]; other site 56107005192 active site 56107005193 UDP-GlcNAc binding site [chemical binding]; other site 56107005194 lipid binding site [chemical binding]; lipid-binding site 56107005195 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 56107005196 Cysteine-rich domain; Region: CCG; pfam02754 56107005197 Cysteine-rich domain; Region: CCG; pfam02754 56107005198 acyl carrier protein; Provisional; Region: acpP; PRK00982 56107005199 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 56107005200 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 56107005201 dimer interface [polypeptide binding]; other site 56107005202 active site 56107005203 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 56107005204 transketolase; Region: PLN02790 56107005205 TPP-binding site [chemical binding]; other site 56107005206 dimer interface [polypeptide binding]; other site 56107005207 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 56107005208 PYR/PP interface [polypeptide binding]; other site 56107005209 dimer interface [polypeptide binding]; other site 56107005210 TPP binding site [chemical binding]; other site 56107005211 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 56107005212 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 56107005213 oligomeric interface; other site 56107005214 putative active site [active] 56107005215 homodimer interface [polypeptide binding]; other site 56107005216 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 56107005217 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 56107005218 NAD(P) binding site [chemical binding]; other site 56107005219 Putative restriction endonuclease; Region: Uma2; pfam05685 56107005220 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 56107005221 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 56107005222 S-layer homology domain; Region: SLH; pfam00395 56107005223 S-layer homology domain; Region: SLH; pfam00395 56107005224 Ion channel; Region: Ion_trans_2; pfam07885 56107005225 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 56107005226 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 56107005227 nucleoside/Zn binding site; other site 56107005228 dimer interface [polypeptide binding]; other site 56107005229 catalytic motif [active] 56107005230 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 56107005231 heme-binding site [chemical binding]; other site 56107005232 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 56107005233 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 56107005234 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 56107005235 G1 box; other site 56107005236 GTP/Mg2+ binding site [chemical binding]; other site 56107005237 G2 box; other site 56107005238 Switch I region; other site 56107005239 G3 box; other site 56107005240 Switch II region; other site 56107005241 G4 box; other site 56107005242 G5 box; other site 56107005243 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 56107005244 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107005245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005246 active site 56107005247 phosphorylation site [posttranslational modification] 56107005248 intermolecular recognition site; other site 56107005249 dimerization interface [polypeptide binding]; other site 56107005250 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107005251 DNA binding residues [nucleotide binding] 56107005252 dimerization interface [polypeptide binding]; other site 56107005253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 56107005254 Histidine kinase; Region: HisKA_3; pfam07730 56107005255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005256 ATP binding site [chemical binding]; other site 56107005257 Mg2+ binding site [ion binding]; other site 56107005258 G-X-G motif; other site 56107005259 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 56107005260 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 56107005261 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 56107005262 catalytic triad [active] 56107005263 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 56107005264 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 56107005265 CheB methylesterase; Region: CheB_methylest; pfam01339 56107005266 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 56107005267 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 56107005268 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 56107005269 PAS fold; Region: PAS; pfam00989 56107005270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005271 putative active site [active] 56107005272 heme pocket [chemical binding]; other site 56107005273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005274 putative active site [active] 56107005275 heme pocket [chemical binding]; other site 56107005276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005277 PAS domain; Region: PAS_9; pfam13426 56107005278 putative active site [active] 56107005279 heme pocket [chemical binding]; other site 56107005280 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107005281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005282 putative active site [active] 56107005283 heme pocket [chemical binding]; other site 56107005284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107005285 dimer interface [polypeptide binding]; other site 56107005286 phosphorylation site [posttranslational modification] 56107005287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005288 ATP binding site [chemical binding]; other site 56107005289 Mg2+ binding site [ion binding]; other site 56107005290 G-X-G motif; other site 56107005291 Response regulator receiver domain; Region: Response_reg; pfam00072 56107005292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005293 active site 56107005294 phosphorylation site [posttranslational modification] 56107005295 intermolecular recognition site; other site 56107005296 dimerization interface [polypeptide binding]; other site 56107005297 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 56107005298 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 56107005299 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 56107005300 catalytic residue [active] 56107005301 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 56107005302 phosphoenolpyruvate synthase; Validated; Region: PRK06464 56107005303 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 56107005304 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 56107005305 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 56107005306 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 56107005307 Ligand Binding Site [chemical binding]; other site 56107005308 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 56107005309 FOG: CBS domain [General function prediction only]; Region: COG0517 56107005310 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 56107005311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005312 PAS domain; Region: PAS_9; pfam13426 56107005313 putative active site [active] 56107005314 heme pocket [chemical binding]; other site 56107005315 PAS domain S-box; Region: sensory_box; TIGR00229 56107005316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005317 putative active site [active] 56107005318 heme pocket [chemical binding]; other site 56107005319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005320 PAS fold; Region: PAS_3; pfam08447 56107005321 putative active site [active] 56107005322 heme pocket [chemical binding]; other site 56107005323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005324 PAS fold; Region: PAS_3; pfam08447 56107005325 putative active site [active] 56107005326 heme pocket [chemical binding]; other site 56107005327 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005328 PAS fold; Region: PAS_3; pfam08447 56107005329 putative active site [active] 56107005330 heme pocket [chemical binding]; other site 56107005331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005332 PAS domain; Region: PAS_9; pfam13426 56107005333 putative active site [active] 56107005334 heme pocket [chemical binding]; other site 56107005335 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107005336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005337 putative active site [active] 56107005338 heme pocket [chemical binding]; other site 56107005339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107005340 dimer interface [polypeptide binding]; other site 56107005341 phosphorylation site [posttranslational modification] 56107005342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005343 ATP binding site [chemical binding]; other site 56107005344 Mg2+ binding site [ion binding]; other site 56107005345 G-X-G motif; other site 56107005346 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107005347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005348 active site 56107005349 phosphorylation site [posttranslational modification] 56107005350 intermolecular recognition site; other site 56107005351 dimerization interface [polypeptide binding]; other site 56107005352 Putative phosphatase (DUF442); Region: DUF442; cl17385 56107005353 sucrose synthase; Region: sucr_synth; TIGR02470 56107005354 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 56107005355 putative ADP-binding pocket [chemical binding]; other site 56107005356 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 56107005357 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 56107005358 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 56107005359 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 56107005360 beta-phosphoglucomutase; Region: bPGM; TIGR01990 56107005361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107005362 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 56107005363 Predicted transcriptional regulator [Transcription]; Region: COG1959 56107005364 Transcriptional regulator; Region: Rrf2; pfam02082 56107005365 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 56107005366 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 56107005367 nickel binding site [ion binding]; other site 56107005368 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107005369 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107005370 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107005371 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107005372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 56107005373 Ligand Binding Site [chemical binding]; other site 56107005374 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107005375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005376 active site 56107005377 phosphorylation site [posttranslational modification] 56107005378 intermolecular recognition site; other site 56107005379 dimerization interface [polypeptide binding]; other site 56107005380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107005381 DNA binding site [nucleotide binding] 56107005382 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 56107005383 putative binding surface; other site 56107005384 active site 56107005385 Response regulator receiver domain; Region: Response_reg; pfam00072 56107005386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005387 active site 56107005388 phosphorylation site [posttranslational modification] 56107005389 intermolecular recognition site; other site 56107005390 dimerization interface [polypeptide binding]; other site 56107005391 Response regulator receiver domain; Region: Response_reg; pfam00072 56107005392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005393 active site 56107005394 phosphorylation site [posttranslational modification] 56107005395 intermolecular recognition site; other site 56107005396 dimerization interface [polypeptide binding]; other site 56107005397 PAS domain S-box; Region: sensory_box; TIGR00229 56107005398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005399 putative active site [active] 56107005400 heme pocket [chemical binding]; other site 56107005401 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107005402 GAF domain; Region: GAF; pfam01590 56107005403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005404 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107005405 putative active site [active] 56107005406 heme pocket [chemical binding]; other site 56107005407 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005408 putative active site [active] 56107005409 heme pocket [chemical binding]; other site 56107005410 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107005411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005412 putative active site [active] 56107005413 heme pocket [chemical binding]; other site 56107005414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107005415 dimer interface [polypeptide binding]; other site 56107005416 phosphorylation site [posttranslational modification] 56107005417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005418 ATP binding site [chemical binding]; other site 56107005419 Mg2+ binding site [ion binding]; other site 56107005420 G-X-G motif; other site 56107005421 Response regulator receiver domain; Region: Response_reg; pfam00072 56107005422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005423 active site 56107005424 phosphorylation site [posttranslational modification] 56107005425 intermolecular recognition site; other site 56107005426 dimerization interface [polypeptide binding]; other site 56107005427 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107005428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005429 active site 56107005430 phosphorylation site [posttranslational modification] 56107005431 intermolecular recognition site; other site 56107005432 dimerization interface [polypeptide binding]; other site 56107005433 Response regulator receiver domain; Region: Response_reg; pfam00072 56107005434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005435 active site 56107005436 phosphorylation site [posttranslational modification] 56107005437 intermolecular recognition site; other site 56107005438 dimerization interface [polypeptide binding]; other site 56107005439 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 56107005440 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 56107005441 haemagglutination activity domain; Region: Haemagg_act; pfam05860 56107005442 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 56107005443 CHAT domain; Region: CHAT; cl17868 56107005444 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 56107005445 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 56107005446 putative active site [active] 56107005447 putative metal binding site [ion binding]; other site 56107005448 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 56107005449 Caspase domain; Region: Peptidase_C14; pfam00656 56107005450 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107005451 structural tetrad; other site 56107005452 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107005453 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107005454 structural tetrad; other site 56107005455 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 56107005456 von Willebrand factor type D domain; Region: VWD; cl02516 56107005457 hypothetical protein; Provisional; Region: PRK09256 56107005458 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 56107005459 S-layer homology domain; Region: SLH; pfam00395 56107005460 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 56107005461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 56107005462 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 56107005463 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 56107005464 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 56107005465 catalytic motif [active] 56107005466 Catalytic residue [active] 56107005467 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 56107005468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107005469 motif II; other site 56107005470 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 56107005471 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 56107005472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107005473 Walker A motif; other site 56107005474 ATP binding site [chemical binding]; other site 56107005475 Walker B motif; other site 56107005476 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 56107005477 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107005478 putative active site [active] 56107005479 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107005480 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107005481 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107005482 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107005483 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107005484 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107005485 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 56107005486 nucleotide binding site/active site [active] 56107005487 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 56107005488 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 56107005489 putative ADP-binding pocket [chemical binding]; other site 56107005490 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 56107005491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107005492 active site 56107005493 motif I; other site 56107005494 motif II; other site 56107005495 PAS domain; Region: PAS_9; pfam13426 56107005496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005497 PAS fold; Region: PAS_3; pfam08447 56107005498 putative active site [active] 56107005499 heme pocket [chemical binding]; other site 56107005500 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107005501 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005502 heme pocket [chemical binding]; other site 56107005503 putative active site [active] 56107005504 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 56107005505 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107005506 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005507 putative active site [active] 56107005508 heme pocket [chemical binding]; other site 56107005509 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005510 putative active site [active] 56107005511 heme pocket [chemical binding]; other site 56107005512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107005513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107005514 dimer interface [polypeptide binding]; other site 56107005515 phosphorylation site [posttranslational modification] 56107005516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005517 ATP binding site [chemical binding]; other site 56107005518 Mg2+ binding site [ion binding]; other site 56107005519 G-X-G motif; other site 56107005520 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107005521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005522 active site 56107005523 phosphorylation site [posttranslational modification] 56107005524 intermolecular recognition site; other site 56107005525 dimerization interface [polypeptide binding]; other site 56107005526 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 56107005527 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 56107005528 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 56107005529 active site 56107005530 ribulose/triose binding site [chemical binding]; other site 56107005531 phosphate binding site [ion binding]; other site 56107005532 substrate (anthranilate) binding pocket [chemical binding]; other site 56107005533 product (indole) binding pocket [chemical binding]; other site 56107005534 PAS domain; Region: PAS_9; pfam13426 56107005535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005536 putative active site [active] 56107005537 heme pocket [chemical binding]; other site 56107005538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107005539 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107005540 dimer interface [polypeptide binding]; other site 56107005541 phosphorylation site [posttranslational modification] 56107005542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005543 ATP binding site [chemical binding]; other site 56107005544 Mg2+ binding site [ion binding]; other site 56107005545 G-X-G motif; other site 56107005546 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107005547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005548 active site 56107005549 phosphorylation site [posttranslational modification] 56107005550 intermolecular recognition site; other site 56107005551 dimerization interface [polypeptide binding]; other site 56107005552 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 56107005553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 56107005554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 56107005555 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 56107005556 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 56107005557 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 56107005558 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 56107005559 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 56107005560 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 56107005561 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 56107005562 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 56107005563 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 56107005564 homodimer interface [polypeptide binding]; other site 56107005565 active site 56107005566 TDP-binding site; other site 56107005567 acceptor substrate-binding pocket; other site 56107005568 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 56107005569 iron-sulfur cluster [ion binding]; other site 56107005570 [2Fe-2S] cluster binding site [ion binding]; other site 56107005571 Pheophorbide a oxygenase; Region: PaO; pfam08417 56107005572 hydroxycinnamoyl-CoA:shikimate/quinate hydroxycinnamoyltransferase; Region: PLN02663 56107005573 Omega-hydroxypalmitate O-feruloyl transferase; Region: PLN02481; cl03601 56107005574 PQQ-like domain; Region: PQQ_2; pfam13360 56107005575 Beta-propeller repeat; Region: SBBP; pfam06739 56107005576 Phospholipid methyltransferase; Region: PEMT; cl17370 56107005577 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 56107005578 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 56107005579 malonyl-CoA binding site [chemical binding]; other site 56107005580 dimer interface [polypeptide binding]; other site 56107005581 active site 56107005582 product binding site; other site 56107005583 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 56107005584 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 56107005585 substrate binding site [chemical binding]; other site 56107005586 oxyanion hole (OAH) forming residues; other site 56107005587 trimer interface [polypeptide binding]; other site 56107005588 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 56107005589 Enoylreductase; Region: PKS_ER; smart00829 56107005590 NAD(P) binding site [chemical binding]; other site 56107005591 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107005592 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 56107005593 active site 56107005594 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107005595 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107005596 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107005597 Thioesterase domain; Region: Thioesterase; pfam00975 56107005598 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 56107005599 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 56107005600 substrate binding site [chemical binding]; other site 56107005601 oxyanion hole (OAH) forming residues; other site 56107005602 trimer interface [polypeptide binding]; other site 56107005603 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 56107005604 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 56107005605 dimer interface [polypeptide binding]; other site 56107005606 active site 56107005607 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 56107005608 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 56107005609 dimer interface [polypeptide binding]; other site 56107005610 active site 56107005611 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107005612 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 56107005613 active site 56107005614 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107005615 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107005616 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107005617 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107005618 acyl carrier protein; Validated; Region: PRK07117 56107005619 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107005620 acyl-CoA synthetase; Validated; Region: PRK05850 56107005621 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 56107005622 acyl-activating enzyme (AAE) consensus motif; other site 56107005623 active site 56107005624 PAS fold; Region: PAS_4; pfam08448 56107005625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005626 putative active site [active] 56107005627 heme pocket [chemical binding]; other site 56107005628 PAS fold; Region: PAS_4; pfam08448 56107005629 PAS domain S-box; Region: sensory_box; TIGR00229 56107005630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 56107005631 putative active site [active] 56107005632 heme pocket [chemical binding]; other site 56107005633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005634 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107005635 putative active site [active] 56107005636 heme pocket [chemical binding]; other site 56107005637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005638 putative active site [active] 56107005639 heme pocket [chemical binding]; other site 56107005640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 56107005641 dimer interface [polypeptide binding]; other site 56107005642 phosphorylation site [posttranslational modification] 56107005643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005644 ATP binding site [chemical binding]; other site 56107005645 Mg2+ binding site [ion binding]; other site 56107005646 G-X-G motif; other site 56107005647 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 56107005648 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 56107005649 CHASE2 domain; Region: CHASE2; pfam05226 56107005650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107005651 MarR family; Region: MarR_2; cl17246 56107005652 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 56107005653 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107005654 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107005655 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107005656 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 56107005657 active site 56107005658 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 56107005659 haemagglutination activity domain; Region: Haemagg_act; pfam05860 56107005660 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 56107005661 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 56107005662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 56107005663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107005664 binding surface 56107005665 TPR motif; other site 56107005666 TPR repeat; Region: TPR_11; pfam13414 56107005667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107005668 binding surface 56107005669 TPR motif; other site 56107005670 TPR repeat; Region: TPR_11; pfam13414 56107005671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107005672 binding surface 56107005673 TPR motif; other site 56107005674 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 56107005675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107005676 binding surface 56107005677 TPR motif; other site 56107005678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107005679 binding surface 56107005680 TPR motif; other site 56107005681 TPR repeat; Region: TPR_11; pfam13414 56107005682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107005683 binding surface 56107005684 TPR motif; other site 56107005685 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 56107005686 RNAase interaction site [polypeptide binding]; other site 56107005687 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 56107005688 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 56107005689 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313 56107005690 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 56107005691 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 56107005692 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 56107005693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107005694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107005695 phosphorylation site [posttranslational modification] 56107005696 dimer interface [polypeptide binding]; other site 56107005697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005698 ATP binding site [chemical binding]; other site 56107005699 Mg2+ binding site [ion binding]; other site 56107005700 G-X-G motif; other site 56107005701 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107005702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005703 active site 56107005704 phosphorylation site [posttranslational modification] 56107005705 intermolecular recognition site; other site 56107005706 dimerization interface [polypeptide binding]; other site 56107005707 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107005708 DNA binding residues [nucleotide binding] 56107005709 dimerization interface [polypeptide binding]; other site 56107005710 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 56107005711 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 56107005712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107005713 Walker A motif; other site 56107005714 ATP binding site [chemical binding]; other site 56107005715 Walker B motif; other site 56107005716 arginine finger; other site 56107005717 AAR2 protein; Region: AAR2; pfam05282 56107005718 Protein kinase domain; Region: Pkinase; pfam00069 56107005719 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 56107005720 active site 56107005721 ATP binding site [chemical binding]; other site 56107005722 substrate binding site [chemical binding]; other site 56107005723 activation loop (A-loop); other site 56107005724 PBP superfamily domain; Region: PBP_like_2; cl17296 56107005725 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313 56107005726 Phage protein D [General function prediction only]; Region: COG3500 56107005727 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 56107005728 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 56107005729 PAAR motif; Region: PAAR_motif; pfam05488 56107005730 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 56107005731 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 56107005732 phage tail protein domain; Region: tail_TIGR02242 56107005733 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107005734 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 56107005735 structural tetrad; other site 56107005736 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107005737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107005738 binding surface 56107005739 TPR motif; other site 56107005740 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107005741 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107005742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107005743 binding surface 56107005744 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107005745 TPR motif; other site 56107005746 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107005747 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107005748 CHAT domain; Region: CHAT; pfam12770 56107005749 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 56107005750 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 56107005751 Surface antigen; Region: Bac_surface_Ag; pfam01103 56107005752 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 56107005753 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 56107005754 active site 56107005755 catalytic triad [active] 56107005756 Uncharacterized conserved protein [Function unknown]; Region: COG4715 56107005757 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 56107005758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 56107005759 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 56107005760 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 56107005761 active site 56107005762 ribulose/triose binding site [chemical binding]; other site 56107005763 phosphate binding site [ion binding]; other site 56107005764 substrate (anthranilate) binding pocket [chemical binding]; other site 56107005765 product (indole) binding pocket [chemical binding]; other site 56107005766 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 56107005767 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 56107005768 catalytic residue [active] 56107005769 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 56107005770 Uncharacterized conserved protein [Function unknown]; Region: COG1430 56107005771 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107005772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005773 active site 56107005774 phosphorylation site [posttranslational modification] 56107005775 intermolecular recognition site; other site 56107005776 dimerization interface [polypeptide binding]; other site 56107005777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107005778 DNA binding site [nucleotide binding] 56107005779 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 56107005780 ATP-NAD kinase; Region: NAD_kinase; pfam01513 56107005781 Ycf39; Provisional; Region: ycf39; CHL00194 56107005782 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 56107005783 NAD(P) binding site [chemical binding]; other site 56107005784 putative active site [active] 56107005785 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 56107005786 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 56107005787 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 56107005788 Replication protein; Region: Rep_1; pfam01446 56107005789 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107005790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005791 active site 56107005792 phosphorylation site [posttranslational modification] 56107005793 intermolecular recognition site; other site 56107005794 dimerization interface [polypeptide binding]; other site 56107005795 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107005796 DNA binding site [nucleotide binding] 56107005797 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 56107005798 active site residue [active] 56107005799 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 56107005800 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 56107005801 catalytic site [active] 56107005802 putative active site [active] 56107005803 putative substrate binding site [chemical binding]; other site 56107005804 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 56107005805 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 56107005806 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 56107005807 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 56107005808 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 56107005809 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 56107005810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107005811 catalytic residue [active] 56107005812 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 56107005813 putative rRNA binding site [nucleotide binding]; other site 56107005814 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 56107005815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 56107005816 binding surface 56107005817 TPR motif; other site 56107005818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 56107005819 TPR motif; other site 56107005820 binding surface 56107005821 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 56107005822 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 56107005823 catalytic loop [active] 56107005824 iron binding site [ion binding]; other site 56107005825 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 56107005826 dinuclear metal binding motif [ion binding]; other site 56107005827 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 56107005828 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 56107005829 [2Fe-2S] cluster binding site [ion binding]; other site 56107005830 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 56107005831 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 56107005832 [2Fe-2S] cluster binding site [ion binding]; other site 56107005833 PemK-like protein; Region: PemK; pfam02452 56107005834 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 56107005835 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 56107005836 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 56107005837 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 56107005838 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 56107005839 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 56107005840 active site 56107005841 putative substrate binding pocket [chemical binding]; other site 56107005842 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 56107005843 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 56107005844 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 56107005845 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 56107005846 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 56107005847 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107005848 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 56107005849 DXD motif; other site 56107005850 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 56107005851 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 56107005852 active site 56107005853 interdomain interaction site; other site 56107005854 putative metal-binding site [ion binding]; other site 56107005855 nucleotide binding site [chemical binding]; other site 56107005856 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 56107005857 domain I; other site 56107005858 DNA binding groove [nucleotide binding] 56107005859 phosphate binding site [ion binding]; other site 56107005860 domain II; other site 56107005861 domain III; other site 56107005862 nucleotide binding site [chemical binding]; other site 56107005863 catalytic site [active] 56107005864 domain IV; other site 56107005865 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107005866 structural tetrad; other site 56107005867 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107005868 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107005869 structural tetrad; other site 56107005870 PQQ-like domain; Region: PQQ_2; pfam13360 56107005871 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 56107005872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 56107005873 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 56107005874 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 56107005875 [2Fe-2S] cluster binding site [ion binding]; other site 56107005876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 56107005877 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 56107005878 putative active site [active] 56107005879 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 56107005880 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 56107005881 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 56107005882 metal ion-dependent adhesion site (MIDAS); other site 56107005883 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 56107005884 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 56107005885 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 56107005886 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 56107005887 putative trimer interface [polypeptide binding]; other site 56107005888 putative CoA binding site [chemical binding]; other site 56107005889 GH3 auxin-responsive promoter; Region: GH3; pfam03321 56107005890 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 56107005891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005892 ATP binding site [chemical binding]; other site 56107005893 Mg2+ binding site [ion binding]; other site 56107005894 G-X-G motif; other site 56107005895 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107005896 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107005897 Probable transposase; Region: OrfB_IS605; pfam01385 56107005898 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107005899 Protein kinase domain; Region: Pkinase; pfam00069 56107005900 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107005901 active site 56107005902 ATP binding site [chemical binding]; other site 56107005903 substrate binding site [chemical binding]; other site 56107005904 activation loop (A-loop); other site 56107005905 AAA ATPase domain; Region: AAA_16; pfam13191 56107005906 Predicted ATPase [General function prediction only]; Region: COG3899 56107005907 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107005908 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107005909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107005910 dimer interface [polypeptide binding]; other site 56107005911 phosphorylation site [posttranslational modification] 56107005912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005913 ATP binding site [chemical binding]; other site 56107005914 Mg2+ binding site [ion binding]; other site 56107005915 G-X-G motif; other site 56107005916 AAA ATPase domain; Region: AAA_16; pfam13191 56107005917 Walker A motif; other site 56107005918 ATP binding site [chemical binding]; other site 56107005919 Walker B motif; other site 56107005920 TPR repeat; Region: TPR_11; pfam13414 56107005921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107005922 binding surface 56107005923 TPR motif; other site 56107005924 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107005925 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107005926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107005927 TPR motif; other site 56107005928 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107005929 binding surface 56107005930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107005931 non-specific DNA binding site [nucleotide binding]; other site 56107005932 salt bridge; other site 56107005933 sequence-specific DNA binding site [nucleotide binding]; other site 56107005934 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 56107005935 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 56107005936 dimer interface [polypeptide binding]; other site 56107005937 PYR/PP interface [polypeptide binding]; other site 56107005938 TPP binding site [chemical binding]; other site 56107005939 substrate binding site [chemical binding]; other site 56107005940 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 56107005941 Domain of unknown function; Region: EKR; pfam10371 56107005942 4Fe-4S binding domain; Region: Fer4_6; pfam12837 56107005943 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 56107005944 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 56107005945 TPP-binding site [chemical binding]; other site 56107005946 dimer interface [polypeptide binding]; other site 56107005947 putative integral membrane protein TIGR02587; Region: TIGR02587 56107005948 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 56107005949 TIGR02588 family protein; Region: TIGR02588 56107005950 PAS fold; Region: PAS_4; pfam08448 56107005951 PAS domain S-box; Region: sensory_box; TIGR00229 56107005952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107005953 putative active site [active] 56107005954 heme pocket [chemical binding]; other site 56107005955 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107005956 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107005957 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107005958 GAF domain; Region: GAF; pfam01590 56107005959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107005960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107005961 dimer interface [polypeptide binding]; other site 56107005962 phosphorylation site [posttranslational modification] 56107005963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107005964 ATP binding site [chemical binding]; other site 56107005965 Mg2+ binding site [ion binding]; other site 56107005966 G-X-G motif; other site 56107005967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107005968 Response regulator receiver domain; Region: Response_reg; pfam00072 56107005969 active site 56107005970 phosphorylation site [posttranslational modification] 56107005971 intermolecular recognition site; other site 56107005972 dimerization interface [polypeptide binding]; other site 56107005973 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 56107005974 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 56107005975 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 56107005976 ResB-like family; Region: ResB; pfam05140 56107005977 Caspase domain; Region: Peptidase_C14; pfam00656 56107005978 gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529 56107005979 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 56107005980 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 56107005981 Uncharacterized conserved protein [Function unknown]; Region: COG3937 56107005982 YCII-related domain; Region: YCII; cl00999 56107005983 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 56107005984 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 56107005985 Uncharacterized conserved protein [Function unknown]; Region: COG2128 56107005986 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 56107005987 ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020 56107005988 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 56107005989 putative multimerization interface [polypeptide binding]; other site 56107005990 DNA methylase; Region: N6_N4_Mtase; cl17433 56107005991 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 56107005992 multimerization interface [polypeptide binding]; other site 56107005993 RbcX protein; Region: RcbX; pfam02341 56107005994 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 56107005995 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 56107005996 homodimer interface [polypeptide binding]; other site 56107005997 active site 56107005998 heterodimer interface [polypeptide binding]; other site 56107005999 catalytic residue [active] 56107006000 metal binding site [ion binding]; metal-binding site 56107006001 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 56107006002 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 56107006003 oligomerization interface [polypeptide binding]; other site 56107006004 active site 56107006005 metal binding site [ion binding]; metal-binding site 56107006006 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 56107006007 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 56107006008 ligand binding site [chemical binding]; other site 56107006009 NAD binding site [chemical binding]; other site 56107006010 dimerization interface [polypeptide binding]; other site 56107006011 catalytic site [active] 56107006012 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 56107006013 putative L-serine binding site [chemical binding]; other site 56107006014 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 56107006015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107006016 S-adenosylmethionine binding site [chemical binding]; other site 56107006017 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 56107006018 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 56107006019 catalytic residues [active] 56107006020 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 56107006021 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 56107006022 NAD(P) binding site [chemical binding]; other site 56107006023 homotetramer interface [polypeptide binding]; other site 56107006024 homodimer interface [polypeptide binding]; other site 56107006025 active site 56107006026 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 56107006027 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 56107006028 Mg++ binding site [ion binding]; other site 56107006029 putative catalytic motif [active] 56107006030 substrate binding site [chemical binding]; other site 56107006031 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 56107006032 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 56107006033 ring oligomerisation interface [polypeptide binding]; other site 56107006034 ATP/Mg binding site [chemical binding]; other site 56107006035 stacking interactions; other site 56107006036 hinge regions; other site 56107006037 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107006038 Protein kinase domain; Region: Pkinase; pfam00069 56107006039 active site 56107006040 ATP binding site [chemical binding]; other site 56107006041 substrate binding site [chemical binding]; other site 56107006042 activation loop (A-loop); other site 56107006043 AAA ATPase domain; Region: AAA_16; pfam13191 56107006044 Predicted ATPase [General function prediction only]; Region: COG3899 56107006045 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107006046 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107006047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107006048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107006049 dimer interface [polypeptide binding]; other site 56107006050 phosphorylation site [posttranslational modification] 56107006051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107006052 ATP binding site [chemical binding]; other site 56107006053 Mg2+ binding site [ion binding]; other site 56107006054 G-X-G motif; other site 56107006055 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 56107006056 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 56107006057 oligomer interface [polypeptide binding]; other site 56107006058 metal binding site [ion binding]; metal-binding site 56107006059 metal binding site [ion binding]; metal-binding site 56107006060 Cl binding site [ion binding]; other site 56107006061 aspartate ring; other site 56107006062 basic sphincter; other site 56107006063 putative hydrophobic gate; other site 56107006064 periplasmic entrance; other site 56107006065 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 56107006066 AAA ATPase domain; Region: AAA_16; pfam13191 56107006067 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 56107006068 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 56107006069 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 56107006070 dimerization interface [polypeptide binding]; other site 56107006071 active site 56107006072 metal binding site [ion binding]; metal-binding site 56107006073 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 56107006074 dsRNA binding site [nucleotide binding]; other site 56107006075 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 56107006076 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 56107006077 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107006078 Probable transposase; Region: OrfB_IS605; pfam01385 56107006079 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107006080 dimerization interface [polypeptide binding]; other site 56107006081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107006082 dimer interface [polypeptide binding]; other site 56107006083 phosphorylation site [posttranslational modification] 56107006084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107006085 ATP binding site [chemical binding]; other site 56107006086 Mg2+ binding site [ion binding]; other site 56107006087 G-X-G motif; other site 56107006088 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 56107006089 RibD C-terminal domain; Region: RibD_C; cl17279 56107006090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 56107006091 Protein of unknown function, DUF482; Region: DUF482; pfam04339 56107006092 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 56107006093 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 56107006094 Repair protein; Region: Repair_PSII; pfam04536 56107006095 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 56107006096 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107006097 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 56107006098 Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370 56107006099 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 56107006100 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107006101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107006102 Walker A/P-loop; other site 56107006103 ATP binding site [chemical binding]; other site 56107006104 Q-loop/lid; other site 56107006105 ABC transporter signature motif; other site 56107006106 Walker B; other site 56107006107 D-loop; other site 56107006108 H-loop/switch region; other site 56107006109 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 56107006110 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 56107006111 NAD binding site [chemical binding]; other site 56107006112 homodimer interface [polypeptide binding]; other site 56107006113 active site 56107006114 substrate binding site [chemical binding]; other site 56107006115 PAS fold; Region: PAS_4; pfam08448 56107006116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 56107006117 putative active site [active] 56107006118 heme pocket [chemical binding]; other site 56107006119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107006120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107006121 dimer interface [polypeptide binding]; other site 56107006122 phosphorylation site [posttranslational modification] 56107006123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107006124 ATP binding site [chemical binding]; other site 56107006125 Mg2+ binding site [ion binding]; other site 56107006126 G-X-G motif; other site 56107006127 Uncharacterized conserved protein [Function unknown]; Region: COG2836 56107006128 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 56107006129 M28 Zn-Peptidases; Region: M28_like_1; cd05640 56107006130 Peptidase family M28; Region: Peptidase_M28; pfam04389 56107006131 metal binding site [ion binding]; metal-binding site 56107006132 AAA ATPase domain; Region: AAA_16; pfam13191 56107006133 NACHT domain; Region: NACHT; pfam05729 56107006134 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107006135 WD domain, G-beta repeat; Region: WD40; pfam00400 56107006136 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107006137 structural tetrad; other site 56107006138 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107006139 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107006140 structural tetrad; other site 56107006141 WD40 repeats; Region: WD40; smart00320 56107006142 WD40 repeats; Region: WD40; smart00320 56107006143 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 56107006144 active site 56107006145 nucleophile elbow; other site 56107006146 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 56107006147 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 56107006148 GIY-YIG motif/motif A; other site 56107006149 active site 56107006150 catalytic site [active] 56107006151 Caspase domain; Region: Peptidase_C14; pfam00656 56107006152 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 56107006153 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 56107006154 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 56107006155 Domain of unknown function (DUF545); Region: SPK; cl11619 56107006156 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 56107006157 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 56107006158 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 56107006159 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 56107006160 HD domain; Region: HD_3; cl17350 56107006161 putative glycosyl transferase; Provisional; Region: PRK10307 56107006162 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 56107006163 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 56107006164 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 56107006165 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 56107006166 Soluble P-type ATPase [General function prediction only]; Region: COG4087 56107006167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107006168 AAA domain; Region: AAA_23; pfam13476 56107006169 AAA domain; Region: AAA_21; pfam13304 56107006170 Walker A/P-loop; other site 56107006171 ATP binding site [chemical binding]; other site 56107006172 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 56107006173 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 56107006174 DNA binding residues [nucleotide binding] 56107006175 dimer interface [polypeptide binding]; other site 56107006176 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 56107006177 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 56107006178 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 56107006179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 56107006180 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 56107006181 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 56107006182 Walker A/P-loop; other site 56107006183 ATP binding site [chemical binding]; other site 56107006184 Q-loop/lid; other site 56107006185 ABC transporter signature motif; other site 56107006186 Walker B; other site 56107006187 D-loop; other site 56107006188 H-loop/switch region; other site 56107006189 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 56107006190 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 56107006191 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 56107006192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107006193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107006194 dimer interface [polypeptide binding]; other site 56107006195 phosphorylation site [posttranslational modification] 56107006196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107006197 ATP binding site [chemical binding]; other site 56107006198 Mg2+ binding site [ion binding]; other site 56107006199 G-X-G motif; other site 56107006200 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 56107006201 adenylosuccinate lyase; Provisional; Region: PRK07380 56107006202 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 56107006203 tetramer interface [polypeptide binding]; other site 56107006204 active site 56107006205 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 56107006206 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 56107006207 catalytic core [active] 56107006208 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 56107006209 EF-hand domain pair; Region: EF_hand_5; pfam13499 56107006210 Ca2+ binding site [ion binding]; other site 56107006211 ferrochelatase; Reviewed; Region: hemH; PRK00035 56107006212 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 56107006213 active site 56107006214 C-terminal domain interface [polypeptide binding]; other site 56107006215 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 56107006216 active site 56107006217 N-terminal domain interface [polypeptide binding]; other site 56107006218 Methyltransferase domain; Region: Methyltransf_23; pfam13489 56107006219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107006220 S-adenosylmethionine binding site [chemical binding]; other site 56107006221 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107006222 topology modulation protein; Reviewed; Region: PRK08118 56107006223 AAA domain; Region: AAA_17; pfam13207 56107006224 HEAT repeats; Region: HEAT_2; pfam13646 56107006225 NACHT domain; Region: NACHT; pfam05729 56107006226 HEAT repeats; Region: HEAT_2; pfam13646 56107006227 Uncharacterized conserved protein [Function unknown]; Region: COG1262 56107006228 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 56107006229 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 56107006230 heterotetramer interface [polypeptide binding]; other site 56107006231 active site pocket [active] 56107006232 cleavage site 56107006233 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 56107006234 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 56107006235 GatB domain; Region: GatB_Yqey; smart00845 56107006236 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 56107006237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107006238 Walker A/P-loop; other site 56107006239 ATP binding site [chemical binding]; other site 56107006240 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 56107006241 putative active site [active] 56107006242 putative metal-binding site [ion binding]; other site 56107006243 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 56107006244 Part of AAA domain; Region: AAA_19; pfam13245 56107006245 Family description; Region: UvrD_C_2; pfam13538 56107006246 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 56107006247 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 56107006248 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 56107006249 active site 56107006250 dimer interface [polypeptide binding]; other site 56107006251 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 56107006252 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 56107006253 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 56107006254 active site 56107006255 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 56107006256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006257 binding surface 56107006258 TPR motif; other site 56107006259 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 56107006260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006261 TPR motif; other site 56107006262 binding surface 56107006263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006264 binding surface 56107006265 TPR motif; other site 56107006266 CHAT domain; Region: CHAT; cl17868 56107006267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107006268 Walker A motif; other site 56107006269 ATP binding site [chemical binding]; other site 56107006270 Walker B motif; other site 56107006271 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 56107006272 protein-splicing catalytic site; other site 56107006273 thioester formation/cholesterol transfer; other site 56107006274 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 56107006275 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 56107006276 protein-splicing catalytic site; other site 56107006277 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 56107006278 DNA polymerase III subunit delta'; Validated; Region: PRK08485 56107006279 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 56107006280 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107006281 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 56107006282 DXD motif; other site 56107006283 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 56107006284 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107006285 DRTGG domain; Region: DRTGG; pfam07085 56107006286 MAPEG family; Region: MAPEG; cl09190 56107006287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 56107006288 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 56107006289 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 56107006290 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 56107006291 putative C-terminal domain interface [polypeptide binding]; other site 56107006292 putative GSH binding site (G-site) [chemical binding]; other site 56107006293 putative dimer interface [polypeptide binding]; other site 56107006294 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 56107006295 N-terminal domain interface [polypeptide binding]; other site 56107006296 dimer interface [polypeptide binding]; other site 56107006297 substrate binding pocket (H-site) [chemical binding]; other site 56107006298 TPR repeat; Region: TPR_11; pfam13414 56107006299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006300 binding surface 56107006301 TPR motif; other site 56107006302 Tetratricopeptide repeat; Region: TPR_16; pfam13432 56107006303 Photosystem I protein M (PsaM); Region: PsaM; pfam07465 56107006304 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 56107006305 D-xylulose kinase; Region: XylB; TIGR01312 56107006306 nucleotide binding site [chemical binding]; other site 56107006307 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 56107006308 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 56107006309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107006310 Walker A motif; other site 56107006311 ATP binding site [chemical binding]; other site 56107006312 Walker B motif; other site 56107006313 arginine finger; other site 56107006314 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 56107006315 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 56107006316 nucleotide binding site [chemical binding]; other site 56107006317 muropeptide transporter; Reviewed; Region: ampG; PRK11902 56107006318 muropeptide transporter; Validated; Region: ampG; cl17669 56107006319 GxxExxY protein; Region: GxxExxY; TIGR04256 56107006320 Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ValS; COG0525 56107006321 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 56107006322 HIGH motif; other site 56107006323 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 56107006324 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 56107006325 active site 56107006326 KMSKS motif; other site 56107006327 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 56107006328 tRNA binding surface [nucleotide binding]; other site 56107006329 anticodon binding site; other site 56107006330 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 56107006331 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 56107006332 ABC1 family; Region: ABC1; cl17513 56107006333 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 56107006334 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 56107006335 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 56107006336 Walker A/P-loop; other site 56107006337 ATP binding site [chemical binding]; other site 56107006338 Q-loop/lid; other site 56107006339 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 56107006340 ABC transporter signature motif; other site 56107006341 Walker B; other site 56107006342 D-loop; other site 56107006343 H-loop/switch region; other site 56107006344 Protein kinase domain; Region: Pkinase; pfam00069 56107006345 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107006346 active site 56107006347 ATP binding site [chemical binding]; other site 56107006348 substrate binding site [chemical binding]; other site 56107006349 activation loop (A-loop); other site 56107006350 AAA ATPase domain; Region: AAA_16; pfam13191 56107006351 Predicted ATPase [General function prediction only]; Region: COG3899 56107006352 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107006353 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107006354 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107006355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107006356 dimer interface [polypeptide binding]; other site 56107006357 phosphorylation site [posttranslational modification] 56107006358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107006359 ATP binding site [chemical binding]; other site 56107006360 Mg2+ binding site [ion binding]; other site 56107006361 G-X-G motif; other site 56107006362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107006363 Response regulator receiver domain; Region: Response_reg; pfam00072 56107006364 active site 56107006365 phosphorylation site [posttranslational modification] 56107006366 intermolecular recognition site; other site 56107006367 dimerization interface [polypeptide binding]; other site 56107006368 Response regulator receiver domain; Region: Response_reg; pfam00072 56107006369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107006370 active site 56107006371 phosphorylation site [posttranslational modification] 56107006372 intermolecular recognition site; other site 56107006373 dimerization interface [polypeptide binding]; other site 56107006374 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 56107006375 dimer interface [polypeptide binding]; other site 56107006376 phosphorylation site [posttranslational modification] 56107006377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107006378 ATP binding site [chemical binding]; other site 56107006379 G-X-G motif; other site 56107006380 cyclase homology domain; Region: CHD; cd07302 56107006381 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 56107006382 nucleotidyl binding site; other site 56107006383 dimer interface [polypeptide binding]; other site 56107006384 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 56107006385 ATP adenylyltransferase; Region: ATP_transf; pfam09830 56107006386 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 56107006387 active site 56107006388 DNA binding site [nucleotide binding] 56107006389 Int/Topo IB signature motif; other site 56107006390 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 56107006391 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 56107006392 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 56107006393 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107006394 putative active site [active] 56107006395 NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180 56107006396 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 56107006397 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 56107006398 Uncharacterized conserved protein [Function unknown]; Region: COG0327 56107006399 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 56107006400 Uncharacterized conserved protein [Function unknown]; Region: COG0432 56107006401 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 56107006402 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 56107006403 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 56107006404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 56107006405 catalytic residue [active] 56107006406 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 56107006407 RNase_H superfamily; Region: RNase_H_2; pfam13482 56107006408 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107006409 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107006410 active site 56107006411 ATP binding site [chemical binding]; other site 56107006412 substrate binding site [chemical binding]; other site 56107006413 activation loop (A-loop); other site 56107006414 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 56107006415 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107006416 active site 56107006417 ATP binding site [chemical binding]; other site 56107006418 substrate binding site [chemical binding]; other site 56107006419 activation loop (A-loop); other site 56107006420 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 56107006421 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 56107006422 HIGH motif; other site 56107006423 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 56107006424 active site 56107006425 KMSKS motif; other site 56107006426 cell division protein; Validated; Region: ftsH; CHL00176 56107006427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107006428 Walker A motif; other site 56107006429 ATP binding site [chemical binding]; other site 56107006430 Walker B motif; other site 56107006431 arginine finger; other site 56107006432 Peptidase family M41; Region: Peptidase_M41; pfam01434 56107006433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107006434 Probable transposase; Region: OrfB_IS605; pfam01385 56107006435 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107006436 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 56107006437 Isochorismatase family; Region: Isochorismatase; pfam00857 56107006438 catalytic triad [active] 56107006439 conserved cis-peptide bond; other site 56107006440 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 56107006441 proline aminopeptidase P II; Provisional; Region: PRK10879 56107006442 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 56107006443 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 56107006444 active site 56107006445 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 56107006446 Family description; Region: VCBS; pfam13517 56107006447 Family description; Region: VCBS; pfam13517 56107006448 Family description; Region: VCBS; pfam13517 56107006449 Family description; Region: VCBS; pfam13517 56107006450 Family description; Region: VCBS; pfam13517 56107006451 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 56107006452 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 56107006453 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 56107006454 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 56107006455 glutamine binding [chemical binding]; other site 56107006456 catalytic triad [active] 56107006457 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 56107006458 metal-binding heat shock protein; Provisional; Region: PRK00016 56107006459 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 56107006460 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 56107006461 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 56107006462 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 56107006463 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 56107006464 DNA binding residues [nucleotide binding] 56107006465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107006466 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 56107006467 Walker A motif; other site 56107006468 ATP binding site [chemical binding]; other site 56107006469 Walker B motif; other site 56107006470 arginine finger; other site 56107006471 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 56107006472 metal ion-dependent adhesion site (MIDAS); other site 56107006473 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107006474 putative active site [active] 56107006475 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 56107006476 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 56107006477 homotetramer interface [polypeptide binding]; other site 56107006478 FMN binding site [chemical binding]; other site 56107006479 homodimer contacts [polypeptide binding]; other site 56107006480 putative active site [active] 56107006481 putative substrate binding site [chemical binding]; other site 56107006482 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 56107006483 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 56107006484 tandem repeat interface [polypeptide binding]; other site 56107006485 oligomer interface [polypeptide binding]; other site 56107006486 active site residues [active] 56107006487 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 56107006488 tandem repeat interface [polypeptide binding]; other site 56107006489 oligomer interface [polypeptide binding]; other site 56107006490 active site residues [active] 56107006491 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 56107006492 Predicted membrane protein [Function unknown]; Region: COG4872 56107006493 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 56107006494 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 56107006495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006496 binding surface 56107006497 TPR motif; other site 56107006498 TPR repeat; Region: TPR_11; pfam13414 56107006499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006500 binding surface 56107006501 TPR motif; other site 56107006502 TPR repeat; Region: TPR_11; pfam13414 56107006503 TPR repeat; Region: TPR_11; pfam13414 56107006504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006505 binding surface 56107006506 TPR motif; other site 56107006507 TPR repeat; Region: TPR_11; pfam13414 56107006508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006509 binding surface 56107006510 TPR motif; other site 56107006511 TPR repeat; Region: TPR_11; pfam13414 56107006512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 56107006513 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107006514 putative active site [active] 56107006515 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 56107006516 TAP-like protein; Region: Abhydrolase_4; pfam08386 56107006517 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 56107006518 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 56107006519 active site 56107006520 Zn binding site [ion binding]; other site 56107006521 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 56107006522 Ligand Binding Site [chemical binding]; other site 56107006523 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 56107006524 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 56107006525 Walker A/P-loop; other site 56107006526 ATP binding site [chemical binding]; other site 56107006527 Q-loop/lid; other site 56107006528 ABC transporter signature motif; other site 56107006529 Walker B; other site 56107006530 D-loop; other site 56107006531 H-loop/switch region; other site 56107006532 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 56107006533 NMT1-like family; Region: NMT1_2; pfam13379 56107006534 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 56107006535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107006536 dimer interface [polypeptide binding]; other site 56107006537 conserved gate region; other site 56107006538 putative PBP binding loops; other site 56107006539 ABC-ATPase subunit interface; other site 56107006540 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 56107006541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107006542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107006543 dimer interface [polypeptide binding]; other site 56107006544 phosphorylation site [posttranslational modification] 56107006545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107006546 ATP binding site [chemical binding]; other site 56107006547 Mg2+ binding site [ion binding]; other site 56107006548 G-X-G motif; other site 56107006549 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 56107006550 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 56107006551 dimerization interface [polypeptide binding]; other site 56107006552 active site 56107006553 metal binding site [ion binding]; metal-binding site 56107006554 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 56107006555 dsRNA binding site [nucleotide binding]; other site 56107006556 LabA_like proteins; Region: LabA_like; cd06167 56107006557 putative metal binding site [ion binding]; other site 56107006558 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 56107006559 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 56107006560 G1 box; other site 56107006561 GTP/Mg2+ binding site [chemical binding]; other site 56107006562 Switch I region; other site 56107006563 G2 box; other site 56107006564 Switch II region; other site 56107006565 G3 box; other site 56107006566 G4 box; other site 56107006567 G5 box; other site 56107006568 Domain of unknown function (DUF697); Region: DUF697; pfam05128 56107006569 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107006570 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107006571 active site 56107006572 ATP binding site [chemical binding]; other site 56107006573 substrate binding site [chemical binding]; other site 56107006574 activation loop (A-loop); other site 56107006575 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107006576 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107006577 active site 56107006578 ATP binding site [chemical binding]; other site 56107006579 substrate binding site [chemical binding]; other site 56107006580 activation loop (A-loop); other site 56107006581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006582 TPR repeat; Region: TPR_11; pfam13414 56107006583 binding surface 56107006584 TPR motif; other site 56107006585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006586 binding surface 56107006587 TPR motif; other site 56107006588 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 56107006589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006590 binding surface 56107006591 TPR motif; other site 56107006592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006593 binding surface 56107006594 TPR motif; other site 56107006595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006596 binding surface 56107006597 TPR motif; other site 56107006598 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 56107006599 NLI interacting factor-like phosphatase; Region: NIF; pfam03031 56107006600 FCP1-like phosphatase, phosphatase domain; Region: FCP1_euk; TIGR02250 56107006601 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 56107006602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107006603 CP12 domain; Region: CP12; pfam02672 56107006604 Dynamin family; Region: Dynamin_N; pfam00350 56107006605 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 56107006606 G1 box; other site 56107006607 GTP/Mg2+ binding site [chemical binding]; other site 56107006608 Switch I region; other site 56107006609 G2 box; other site 56107006610 Switch II region; other site 56107006611 G3 box; other site 56107006612 G4 box; other site 56107006613 G5 box; other site 56107006614 Domain of unknown function (DUF697); Region: DUF697; pfam05128 56107006615 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 56107006616 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 56107006617 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 56107006618 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 56107006619 metal binding site [ion binding]; metal-binding site 56107006620 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 56107006621 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 56107006622 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 56107006623 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 56107006624 ABC-ATPase subunit interface; other site 56107006625 dimer interface [polypeptide binding]; other site 56107006626 putative PBP binding regions; other site 56107006627 photosystem I reaction center subunit X-like protein; Reviewed; Region: PRK13216 56107006628 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 56107006629 Peptidase family M50; Region: Peptidase_M50; pfam02163 56107006630 active site 56107006631 putative substrate binding region [chemical binding]; other site 56107006632 FOG: CBS domain [General function prediction only]; Region: COG0517 56107006633 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 56107006634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107006635 Probable transposase; Region: OrfB_IS605; pfam01385 56107006636 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107006637 phosphoenolpyruvate synthase; Validated; Region: PRK06464 56107006638 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 56107006639 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 56107006640 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 56107006641 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 56107006642 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 56107006643 GAF domain; Region: GAF; pfam01590 56107006644 Phytochrome region; Region: PHY; pfam00360 56107006645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107006646 dimer interface [polypeptide binding]; other site 56107006647 phosphorylation site [posttranslational modification] 56107006648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107006649 ATP binding site [chemical binding]; other site 56107006650 Mg2+ binding site [ion binding]; other site 56107006651 G-X-G motif; other site 56107006652 Response regulator receiver domain; Region: Response_reg; pfam00072 56107006653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107006654 active site 56107006655 phosphorylation site [posttranslational modification] 56107006656 intermolecular recognition site; other site 56107006657 dimerization interface [polypeptide binding]; other site 56107006658 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107006659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107006660 active site 56107006661 phosphorylation site [posttranslational modification] 56107006662 intermolecular recognition site; other site 56107006663 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107006664 dimerization interface [polypeptide binding]; other site 56107006665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107006666 dimer interface [polypeptide binding]; other site 56107006667 phosphorylation site [posttranslational modification] 56107006668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107006669 ATP binding site [chemical binding]; other site 56107006670 Mg2+ binding site [ion binding]; other site 56107006671 G-X-G motif; other site 56107006672 Homeodomain-like domain; Region: HTH_23; pfam13384 56107006673 Winged helix-turn helix; Region: HTH_29; pfam13551 56107006674 Winged helix-turn helix; Region: HTH_33; pfam13592 56107006675 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107006676 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107006677 ligand binding site [chemical binding]; other site 56107006678 flexible hinge region; other site 56107006679 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 56107006680 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 56107006681 putative active site [active] 56107006682 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107006683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107006684 Walker A/P-loop; other site 56107006685 ATP binding site [chemical binding]; other site 56107006686 Q-loop/lid; other site 56107006687 ABC transporter signature motif; other site 56107006688 Walker B; other site 56107006689 D-loop; other site 56107006690 H-loop/switch region; other site 56107006691 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 56107006692 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 56107006693 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107006694 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 56107006695 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 56107006696 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 56107006697 Phosphotransferase enzyme family; Region: APH; pfam01636 56107006698 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 56107006699 substrate binding site [chemical binding]; other site 56107006700 Phosphotransferase enzyme family; Region: APH; pfam01636 56107006701 serine/threonine protein kinase; Provisional; Region: PRK14879 56107006702 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 56107006703 substrate binding site [chemical binding]; other site 56107006704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107006705 S-adenosylmethionine binding site [chemical binding]; other site 56107006706 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 56107006707 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 56107006708 active site 56107006709 metal binding site [ion binding]; metal-binding site 56107006710 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107006711 flagellar assembly protein H; Validated; Region: fliH; PRK06669 56107006712 HEAT repeats; Region: HEAT_2; pfam13646 56107006713 HEAT repeats; Region: HEAT_2; pfam13646 56107006714 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107006715 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107006716 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107006717 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107006718 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107006719 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107006720 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107006721 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107006722 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107006723 HEAT repeats; Region: HEAT_2; pfam13646 56107006724 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 56107006725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 56107006726 FIST N domain; Region: FIST; pfam08495 56107006727 FIST C domain; Region: FIST_C; pfam10442 56107006728 CP12 domain; Region: CP12; pfam02672 56107006729 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 56107006730 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 56107006731 GMP synthase; Reviewed; Region: guaA; PRK00074 56107006732 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 56107006733 AMP/PPi binding site [chemical binding]; other site 56107006734 candidate oxyanion hole; other site 56107006735 catalytic triad [active] 56107006736 potential glutamine specificity residues [chemical binding]; other site 56107006737 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 56107006738 ATP Binding subdomain [chemical binding]; other site 56107006739 Ligand Binding sites [chemical binding]; other site 56107006740 Dimerization subdomain; other site 56107006741 Response regulator receiver domain; Region: Response_reg; pfam00072 56107006742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107006743 active site 56107006744 phosphorylation site [posttranslational modification] 56107006745 intermolecular recognition site; other site 56107006746 dimerization interface [polypeptide binding]; other site 56107006747 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 56107006748 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 56107006749 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 56107006750 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 56107006751 Protein of unknown function (DUF751); Region: DUF751; pfam05421 56107006752 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 56107006753 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 56107006754 hypothetical protein; Provisional; Region: PRK04194 56107006755 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 56107006756 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 56107006757 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 56107006758 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 56107006759 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 56107006760 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 56107006761 substrate binding site [chemical binding]; other site 56107006762 active site 56107006763 catalytic residues [active] 56107006764 heterodimer interface [polypeptide binding]; other site 56107006765 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107006766 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107006767 active site 56107006768 ATP binding site [chemical binding]; other site 56107006769 substrate binding site [chemical binding]; other site 56107006770 activation loop (A-loop); other site 56107006771 Bacterial SH3 domain homologues; Region: SH3b; smart00287 56107006772 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107006773 DNA binding residues [nucleotide binding] 56107006774 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107006775 dimerization interface [polypeptide binding]; other site 56107006776 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 56107006777 MgtE intracellular N domain; Region: MgtE_N; smart00924 56107006778 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 56107006779 Divalent cation transporter; Region: MgtE; pfam01769 56107006780 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 56107006781 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 56107006782 catalytic residues [active] 56107006783 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 56107006784 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 56107006785 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 56107006786 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107006787 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107006788 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107006789 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107006790 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107006791 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107006792 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107006793 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107006794 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107006795 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107006796 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107006797 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107006798 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 56107006799 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 56107006800 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 56107006801 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 56107006802 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 56107006803 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 56107006804 RNA binding site [nucleotide binding]; other site 56107006805 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 56107006806 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 56107006807 catalytic loop [active] 56107006808 iron binding site [ion binding]; other site 56107006809 Predicted membrane protein [Function unknown]; Region: COG1950 56107006810 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 56107006811 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 56107006812 cytochrome c6; Provisional; Region: PRK13697 56107006813 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 56107006814 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 56107006815 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 56107006816 active site 56107006817 catalytic tetrad [active] 56107006818 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 56107006819 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 56107006820 active site 56107006821 metal binding site [ion binding]; metal-binding site 56107006822 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 56107006823 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107006824 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107006825 putative active site [active] 56107006826 heme pocket [chemical binding]; other site 56107006827 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107006828 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107006829 putative active site [active] 56107006830 heme pocket [chemical binding]; other site 56107006831 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107006832 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107006833 GAF domain; Region: GAF; pfam01590 56107006834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107006835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107006836 dimer interface [polypeptide binding]; other site 56107006837 phosphorylation site [posttranslational modification] 56107006838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107006839 ATP binding site [chemical binding]; other site 56107006840 Mg2+ binding site [ion binding]; other site 56107006841 G-X-G motif; other site 56107006842 Response regulator receiver domain; Region: Response_reg; pfam00072 56107006843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107006844 active site 56107006845 phosphorylation site [posttranslational modification] 56107006846 intermolecular recognition site; other site 56107006847 dimerization interface [polypeptide binding]; other site 56107006848 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 56107006849 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 56107006850 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 56107006851 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 56107006852 [2Fe-2S] cluster binding site [ion binding]; other site 56107006853 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 56107006854 substrate binding pocket [chemical binding]; other site 56107006855 substrate-Mg2+ binding site; other site 56107006856 aspartate-rich region 1; other site 56107006857 aspartate-rich region 2; other site 56107006858 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 56107006859 DNA methylase; Region: N6_N4_Mtase; pfam01555 56107006860 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 56107006861 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 56107006862 molybdopterin cofactor binding site; other site 56107006863 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 56107006864 molybdopterin cofactor binding site; other site 56107006865 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 56107006866 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 56107006867 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 56107006868 active site 56107006869 catalytic site [active] 56107006870 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 56107006871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107006872 FeS/SAM binding site; other site 56107006873 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 56107006874 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 56107006875 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 56107006876 putative NADP binding site [chemical binding]; other site 56107006877 putative substrate binding site [chemical binding]; other site 56107006878 active site 56107006879 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 56107006880 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 56107006881 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 56107006882 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 56107006883 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107006884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107006885 active site 56107006886 phosphorylation site [posttranslational modification] 56107006887 intermolecular recognition site; other site 56107006888 dimerization interface [polypeptide binding]; other site 56107006889 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107006890 DNA binding residues [nucleotide binding] 56107006891 dimerization interface [polypeptide binding]; other site 56107006892 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107006893 GAF domain; Region: GAF; pfam01590 56107006894 GAF domain; Region: GAF; pfam01590 56107006895 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107006896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107006897 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107006898 putative active site [active] 56107006899 heme pocket [chemical binding]; other site 56107006900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107006901 putative active site [active] 56107006902 heme pocket [chemical binding]; other site 56107006903 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107006904 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107006905 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107006906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107006907 dimer interface [polypeptide binding]; other site 56107006908 phosphorylation site [posttranslational modification] 56107006909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107006910 ATP binding site [chemical binding]; other site 56107006911 Mg2+ binding site [ion binding]; other site 56107006912 G-X-G motif; other site 56107006913 Response regulator receiver domain; Region: Response_reg; pfam00072 56107006914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107006915 active site 56107006916 phosphorylation site [posttranslational modification] 56107006917 intermolecular recognition site; other site 56107006918 dimerization interface [polypeptide binding]; other site 56107006919 short chain dehydrogenase; Provisional; Region: PRK07109 56107006920 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 56107006921 putative NAD(P) binding site [chemical binding]; other site 56107006922 active site 56107006923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107006924 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107006925 Probable transposase; Region: OrfB_IS605; pfam01385 56107006926 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107006927 Uncharacterized conserved protein [Function unknown]; Region: COG3287 56107006928 FIST N domain; Region: FIST; pfam08495 56107006929 FIST C domain; Region: FIST_C; pfam10442 56107006930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107006931 ATP binding site [chemical binding]; other site 56107006932 Mg2+ binding site [ion binding]; other site 56107006933 G-X-G motif; other site 56107006934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006935 binding surface 56107006936 TPR motif; other site 56107006937 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107006938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006939 binding surface 56107006940 TPR motif; other site 56107006941 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107006942 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107006943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006944 binding surface 56107006945 TPR motif; other site 56107006946 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107006947 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107006948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006949 binding surface 56107006950 TPR motif; other site 56107006951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107006952 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107006953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006954 binding surface 56107006955 TPR motif; other site 56107006956 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107006957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107006958 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107006959 CHAT domain; Region: CHAT; pfam12770 56107006960 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 56107006961 Lectin C-type domain; Region: Lectin_C; pfam00059 56107006962 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107006963 Ca2+ binding site [ion binding]; other site 56107006964 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107006965 Ca2+ binding site [ion binding]; other site 56107006966 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107006967 Ca2+ binding site [ion binding]; other site 56107006968 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107006969 Ca2+ binding site [ion binding]; other site 56107006970 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107006971 Ca2+ binding site [ion binding]; other site 56107006972 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107006973 Ca2+ binding site [ion binding]; other site 56107006974 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107006975 Ca2+ binding site [ion binding]; other site 56107006976 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 56107006977 active site 56107006978 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 56107006979 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107006980 Ca2+ binding site [ion binding]; other site 56107006981 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107006982 Ca2+ binding site [ion binding]; other site 56107006983 Cadherin repeat-like domain; Region: CA_like; cl15786 56107006984 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 56107006985 Ca2+ binding site [ion binding]; other site 56107006986 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 56107006987 Cadherin repeat-like domain; Region: CA_like; cl15786 56107006988 Ca2+ binding site [ion binding]; other site 56107006989 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 56107006990 PKC phosphorylation site [posttranslational modification]; other site 56107006991 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 56107006992 Peptidase family M48; Region: Peptidase_M48; cl12018 56107006993 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 56107006994 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 56107006995 putative active site [active] 56107006996 adenylation catalytic residue [active] 56107006997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107006998 binding surface 56107006999 TPR motif; other site 56107007000 TPR repeat; Region: TPR_11; pfam13414 56107007001 hypothetical protein; Validated; Region: PRK07198 56107007002 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 56107007003 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 56107007004 dimerization interface [polypeptide binding]; other site 56107007005 active site 56107007006 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 56107007007 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 56107007008 active site 56107007009 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 56107007010 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 56107007011 TM-ABC transporter signature motif; other site 56107007012 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 56107007013 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 56107007014 TM-ABC transporter signature motif; other site 56107007015 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107007016 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107007017 active site 56107007018 ATP binding site [chemical binding]; other site 56107007019 substrate binding site [chemical binding]; other site 56107007020 activation loop (A-loop); other site 56107007021 AAA ATPase domain; Region: AAA_16; pfam13191 56107007022 Predicted ATPase [General function prediction only]; Region: COG3899 56107007023 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107007024 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107007025 PAS fold; Region: PAS_4; pfam08448 56107007026 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107007027 putative active site [active] 56107007028 heme pocket [chemical binding]; other site 56107007029 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 56107007030 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 56107007031 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 56107007032 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 56107007033 Walker A/P-loop; other site 56107007034 ATP binding site [chemical binding]; other site 56107007035 Q-loop/lid; other site 56107007036 ABC transporter signature motif; other site 56107007037 Walker B; other site 56107007038 D-loop; other site 56107007039 H-loop/switch region; other site 56107007040 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 56107007041 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 56107007042 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 56107007043 putative ligand binding site [chemical binding]; other site 56107007044 Predicted membrane protein [Function unknown]; Region: COG4270 56107007045 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 56107007046 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 56107007047 Ligand binding site; other site 56107007048 metal-binding site 56107007049 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 56107007050 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 56107007051 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 56107007052 XdhC Rossmann domain; Region: XdhC_C; pfam13478 56107007053 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 56107007054 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 56107007055 catalytic loop [active] 56107007056 iron binding site [ion binding]; other site 56107007057 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 56107007058 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 56107007059 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 56107007060 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 56107007061 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 56107007062 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 56107007063 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 56107007064 putative active site [active] 56107007065 putative catalytic site [active] 56107007066 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 56107007067 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 56107007068 NodB motif; other site 56107007069 active site 56107007070 catalytic site [active] 56107007071 metal binding site [ion binding]; metal-binding site 56107007072 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 56107007073 nudix motif; other site 56107007074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107007075 NADH(P)-binding; Region: NAD_binding_10; pfam13460 56107007076 NAD(P) binding site [chemical binding]; other site 56107007077 active site 56107007078 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 56107007079 haemagglutination activity domain; Region: Haemagg_act; pfam05860 56107007080 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 56107007081 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 56107007082 homodimer interface [polypeptide binding]; other site 56107007083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107007084 catalytic residue [active] 56107007085 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 56107007086 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 56107007087 putative ligand binding site [chemical binding]; other site 56107007088 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 56107007089 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 56107007090 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 56107007091 acyl-activating enzyme (AAE) consensus motif; other site 56107007092 acyl-activating enzyme (AAE) consensus motif; other site 56107007093 putative AMP binding site [chemical binding]; other site 56107007094 putative active site [active] 56107007095 putative CoA binding site [chemical binding]; other site 56107007096 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 56107007097 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 56107007098 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 56107007099 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 56107007100 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 56107007101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107007102 NAD(P) binding site [chemical binding]; other site 56107007103 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 56107007104 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 56107007105 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 56107007106 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 56107007107 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 56107007108 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 56107007109 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 56107007110 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 56107007111 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 56107007112 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 56107007113 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107007114 Ca2+ binding site [ion binding]; other site 56107007115 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107007116 Ca2+ binding site [ion binding]; other site 56107007117 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107007118 Ca2+ binding site [ion binding]; other site 56107007119 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 56107007120 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 56107007121 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 56107007122 dimanganese center [ion binding]; other site 56107007123 Cupin domain; Region: Cupin_2; pfam07883 56107007124 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 56107007125 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 56107007126 NAD binding site [chemical binding]; other site 56107007127 catalytic Zn binding site [ion binding]; other site 56107007128 structural Zn binding site [ion binding]; other site 56107007129 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 56107007130 putative hydrophobic ligand binding site [chemical binding]; other site 56107007131 intracellular protease, PfpI family; Region: PfpI; TIGR01382 56107007132 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 56107007133 proposed catalytic triad [active] 56107007134 conserved cys residue [active] 56107007135 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 56107007136 dinuclear metal binding motif [ion binding]; other site 56107007137 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 56107007138 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 56107007139 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 56107007140 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 56107007141 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 56107007142 Walker A/P-loop; other site 56107007143 ATP binding site [chemical binding]; other site 56107007144 Q-loop/lid; other site 56107007145 ABC transporter signature motif; other site 56107007146 Walker B; other site 56107007147 D-loop; other site 56107007148 H-loop/switch region; other site 56107007149 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 56107007150 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 56107007151 Walker A/P-loop; other site 56107007152 ATP binding site [chemical binding]; other site 56107007153 Q-loop/lid; other site 56107007154 ABC transporter signature motif; other site 56107007155 Walker B; other site 56107007156 D-loop; other site 56107007157 H-loop/switch region; other site 56107007158 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107007159 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107007160 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107007161 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107007162 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107007163 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107007164 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107007165 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 56107007166 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 56107007167 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 56107007168 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 56107007169 Active site cavity [active] 56107007170 catalytic acid [active] 56107007171 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 56107007172 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 56107007173 DXD motif; other site 56107007174 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 56107007175 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 56107007176 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 56107007177 nucleotide binding site [chemical binding]; other site 56107007178 2TM domain; Region: 2TM; pfam13239 56107007179 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 56107007180 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 56107007181 Predicted transcriptional regulators [Transcription]; Region: COG1733 56107007182 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 56107007183 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 56107007184 metal ion-dependent adhesion site (MIDAS); other site 56107007185 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 56107007186 metal ion-dependent adhesion site (MIDAS); other site 56107007187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 56107007188 NACHT domain; Region: NACHT; pfam05729 56107007189 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107007190 structural tetrad; other site 56107007191 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107007192 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107007193 structural tetrad; other site 56107007194 AAA ATPase domain; Region: AAA_16; pfam13191 56107007195 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 56107007196 active site 56107007197 putative substrate binding region [chemical binding]; other site 56107007198 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 56107007199 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 56107007200 dimerization interface [polypeptide binding]; other site 56107007201 putative DNA binding site [nucleotide binding]; other site 56107007202 putative Zn2+ binding site [ion binding]; other site 56107007203 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 56107007204 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 56107007205 catalytic residues [active] 56107007206 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 56107007207 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 56107007208 FMN binding site [chemical binding]; other site 56107007209 active site 56107007210 substrate binding site [chemical binding]; other site 56107007211 catalytic residue [active] 56107007212 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 56107007213 dimer interface [polypeptide binding]; other site 56107007214 FMN binding site [chemical binding]; other site 56107007215 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 56107007216 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 56107007217 C-terminal domain interface [polypeptide binding]; other site 56107007218 GSH binding site (G-site) [chemical binding]; other site 56107007219 dimer interface [polypeptide binding]; other site 56107007220 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 56107007221 N-terminal domain interface [polypeptide binding]; other site 56107007222 putative dimer interface [polypeptide binding]; other site 56107007223 active site 56107007224 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 56107007225 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 56107007226 TAP-like protein; Region: Abhydrolase_4; pfam08386 56107007227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107007228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107007229 ATP binding site [chemical binding]; other site 56107007230 Mg2+ binding site [ion binding]; other site 56107007231 G-X-G motif; other site 56107007232 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 56107007233 PAS fold; Region: PAS_4; pfam08448 56107007234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107007235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107007236 dimer interface [polypeptide binding]; other site 56107007237 phosphorylation site [posttranslational modification] 56107007238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107007239 ATP binding site [chemical binding]; other site 56107007240 Mg2+ binding site [ion binding]; other site 56107007241 G-X-G motif; other site 56107007242 thymidylate kinase; Validated; Region: tmk; PRK00698 56107007243 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 56107007244 TMP-binding site; other site 56107007245 ATP-binding site [chemical binding]; other site 56107007246 DNA polymerase III subunit delta'; Validated; Region: PRK07399 56107007247 AAA ATPase domain; Region: AAA_16; pfam13191 56107007248 Walker A motif; other site 56107007249 ATP binding site [chemical binding]; other site 56107007250 Walker B motif; other site 56107007251 arginine finger; other site 56107007252 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 56107007253 ParB-like nuclease domain; Region: ParB; smart00470 56107007254 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 56107007255 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 56107007256 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 56107007257 nucleophilic elbow; other site 56107007258 catalytic triad; other site 56107007259 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 56107007260 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 56107007261 Subunit I/III interface [polypeptide binding]; other site 56107007262 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 56107007263 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 56107007264 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 56107007265 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 56107007266 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 56107007267 Predicted membrane protein [Function unknown]; Region: COG4244 56107007268 Predicted membrane protein [Function unknown]; Region: COG4244 56107007269 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 56107007270 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 56107007271 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 56107007272 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 56107007273 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 56107007274 Mechanosensitive ion channel; Region: MS_channel; pfam00924 56107007275 Domain of unknown function (DUF427); Region: DUF427; cl00998 56107007276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 56107007277 Radical SAM superfamily; Region: Radical_SAM; pfam04055 56107007278 FeS/SAM binding site; other site 56107007279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107007280 dimer interface [polypeptide binding]; other site 56107007281 ABC-ATPase subunit interface; other site 56107007282 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 56107007283 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 56107007284 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 56107007285 Walker A/P-loop; other site 56107007286 ATP binding site [chemical binding]; other site 56107007287 Q-loop/lid; other site 56107007288 ABC transporter signature motif; other site 56107007289 Walker B; other site 56107007290 D-loop; other site 56107007291 H-loop/switch region; other site 56107007292 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 56107007293 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 56107007294 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 56107007295 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107007296 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 56107007297 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 56107007298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107007299 dimer interface [polypeptide binding]; other site 56107007300 conserved gate region; other site 56107007301 putative PBP binding loops; other site 56107007302 ABC-ATPase subunit interface; other site 56107007303 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107007304 putative active site [active] 56107007305 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 56107007306 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 56107007307 Integrase core domain; Region: rve; pfam00665 56107007308 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 56107007309 AAA domain; Region: AAA_22; pfam13401 56107007310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 56107007311 Walker A motif; other site 56107007312 ATP binding site [chemical binding]; other site 56107007313 Walker B motif; other site 56107007314 TniQ; Region: TniQ; pfam06527 56107007315 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 56107007316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107007317 dimer interface [polypeptide binding]; other site 56107007318 conserved gate region; other site 56107007319 putative PBP binding loops; other site 56107007320 ABC-ATPase subunit interface; other site 56107007321 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 56107007322 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 56107007323 Tricarboxylate carrier; Region: Mtc; cl04275 56107007324 photosystem II 47 kDa protein; Region: psbB; CHL00062 56107007325 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 56107007326 30S ribosomal protein S1; Reviewed; Region: PRK07400 56107007327 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 56107007328 RNA binding site [nucleotide binding]; other site 56107007329 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 56107007330 RNA binding site [nucleotide binding]; other site 56107007331 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 56107007332 RNA binding site [nucleotide binding]; other site 56107007333 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 56107007334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107007335 motif II; other site 56107007336 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107007337 putative active site [active] 56107007338 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 56107007339 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 56107007340 Walker A/P-loop; other site 56107007341 ATP binding site [chemical binding]; other site 56107007342 Q-loop/lid; other site 56107007343 ABC transporter signature motif; other site 56107007344 Walker B; other site 56107007345 D-loop; other site 56107007346 H-loop/switch region; other site 56107007347 TOBE-like domain; Region: TOBE_3; pfam12857 56107007348 Haemolytic domain; Region: Haemolytic; cl00506 56107007349 geranylgeranyl reductase; Region: ChlP; TIGR02028 56107007350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 56107007351 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107007352 putative active site [active] 56107007353 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107007354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107007355 active site 56107007356 phosphorylation site [posttranslational modification] 56107007357 intermolecular recognition site; other site 56107007358 dimerization interface [polypeptide binding]; other site 56107007359 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107007360 DNA binding site [nucleotide binding] 56107007361 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 56107007362 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 56107007363 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 56107007364 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 56107007365 classical (c) SDRs; Region: SDR_c; cd05233 56107007366 NAD(P) binding site [chemical binding]; other site 56107007367 active site 56107007368 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107007369 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 56107007370 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 56107007371 putative NAD(P) binding site [chemical binding]; other site 56107007372 active site 56107007373 putative substrate binding site [chemical binding]; other site 56107007374 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 56107007375 FMN binding site [chemical binding]; other site 56107007376 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 56107007377 substrate binding site [chemical binding]; other site 56107007378 putative catalytic residue [active] 56107007379 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107007380 active site 56107007381 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 56107007382 Acyl transferase domain; Region: Acyl_transf_1; cl08282 56107007383 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107007384 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 56107007385 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107007386 active site 56107007387 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 56107007388 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 56107007389 putative NADP binding site [chemical binding]; other site 56107007390 active site 56107007391 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107007392 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 56107007393 active site 56107007394 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 56107007395 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107007396 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 56107007397 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 56107007398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107007399 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 56107007400 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 56107007401 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107007402 DevC protein; Region: devC; TIGR01185 56107007403 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 56107007404 FtsX-like permease family; Region: FtsX; pfam02687 56107007405 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 56107007406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107007407 NAD(P) binding site [chemical binding]; other site 56107007408 active site 56107007409 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107007410 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 56107007411 active site 56107007412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 56107007413 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 56107007414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 56107007415 active site 56107007416 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107007417 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 56107007418 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107007419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 56107007420 TPR motif; other site 56107007421 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107007422 binding surface 56107007423 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 56107007424 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 56107007425 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 56107007426 active site 56107007427 metal binding site [ion binding]; metal-binding site 56107007428 hexamer interface [polypeptide binding]; other site 56107007429 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 56107007430 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107007431 active site 56107007432 catalytic residues [active] 56107007433 DNA binding site [nucleotide binding] 56107007434 Int/Topo IB signature motif; other site 56107007435 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 56107007436 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107007437 salt bridge; other site 56107007438 non-specific DNA binding site [nucleotide binding]; other site 56107007439 sequence-specific DNA binding site [nucleotide binding]; other site 56107007440 KGK domain; Region: KGK; pfam08872 56107007441 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 56107007442 D5 N terminal like; Region: D5_N; smart00885 56107007443 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 56107007444 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 56107007445 metal binding site [ion binding]; metal-binding site 56107007446 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 56107007447 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 56107007448 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 56107007449 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 56107007450 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 56107007451 ABC-ATPase subunit interface; other site 56107007452 dimer interface [polypeptide binding]; other site 56107007453 putative PBP binding regions; other site 56107007454 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 56107007455 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 56107007456 Walker A/P-loop; other site 56107007457 ATP binding site [chemical binding]; other site 56107007458 Q-loop/lid; other site 56107007459 ABC transporter signature motif; other site 56107007460 Walker B; other site 56107007461 D-loop; other site 56107007462 H-loop/switch region; other site 56107007463 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 56107007464 GIY-YIG motif/motif A; other site 56107007465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107007466 dimer interface [polypeptide binding]; other site 56107007467 conserved gate region; other site 56107007468 putative PBP binding loops; other site 56107007469 ABC-ATPase subunit interface; other site 56107007470 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 56107007471 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 56107007472 catalytic site [active] 56107007473 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 56107007474 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 56107007475 Family of unknown function (DUF490); Region: DUF490; pfam04357 56107007476 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 56107007477 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 56107007478 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 56107007479 putative active site [active] 56107007480 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107007481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107007482 active site 56107007483 phosphorylation site [posttranslational modification] 56107007484 intermolecular recognition site; other site 56107007485 dimerization interface [polypeptide binding]; other site 56107007486 Response regulator receiver domain; Region: Response_reg; pfam00072 56107007487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107007488 active site 56107007489 phosphorylation site [posttranslational modification] 56107007490 intermolecular recognition site; other site 56107007491 dimerization interface [polypeptide binding]; other site 56107007492 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 56107007493 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107007494 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107007495 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107007496 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107007497 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107007498 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107007499 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107007500 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107007501 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 56107007502 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 56107007503 dimer interface [polypeptide binding]; other site 56107007504 putative CheW interface [polypeptide binding]; other site 56107007505 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 56107007506 putative binding surface; other site 56107007507 active site 56107007508 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 56107007509 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 56107007510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107007511 ATP binding site [chemical binding]; other site 56107007512 Mg2+ binding site [ion binding]; other site 56107007513 G-X-G motif; other site 56107007514 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 56107007515 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107007516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107007517 active site 56107007518 phosphorylation site [posttranslational modification] 56107007519 intermolecular recognition site; other site 56107007520 dimerization interface [polypeptide binding]; other site 56107007521 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 56107007522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107007523 dimer interface [polypeptide binding]; other site 56107007524 conserved gate region; other site 56107007525 putative PBP binding loops; other site 56107007526 ABC-ATPase subunit interface; other site 56107007527 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 56107007528 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 56107007529 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 56107007530 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 56107007531 Walker A/P-loop; other site 56107007532 ATP binding site [chemical binding]; other site 56107007533 Q-loop/lid; other site 56107007534 ABC transporter signature motif; other site 56107007535 Walker B; other site 56107007536 D-loop; other site 56107007537 H-loop/switch region; other site 56107007538 TOBE domain; Region: TOBE_2; pfam08402 56107007539 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 56107007540 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 56107007541 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 56107007542 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 56107007543 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 56107007544 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 56107007545 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 56107007546 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 56107007547 Predicted permeases [General function prediction only]; Region: COG0679 56107007548 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 56107007549 active site 56107007550 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 56107007551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107007552 putative substrate translocation pore; other site 56107007553 DNA Topoisomerase IV; Region: TOP4c; smart00434 56107007554 Uncharacterized conserved protein (DUF2305); Region: DUF2305; pfam10230 56107007555 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 56107007556 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 56107007557 Chromate transporter; Region: Chromate_transp; pfam02417 56107007558 Putative phosphatase (DUF442); Region: DUF442; cl17385 56107007559 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 56107007560 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 56107007561 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 56107007562 N-terminal domain interface [polypeptide binding]; other site 56107007563 dimer interface [polypeptide binding]; other site 56107007564 substrate binding pocket (H-site) [chemical binding]; other site 56107007565 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 56107007566 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 56107007567 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 56107007568 active site 56107007569 catalytic tetrad [active] 56107007570 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 56107007571 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 56107007572 active site 56107007573 RRXRR protein; Region: RRXRR; pfam14239 56107007574 hypothetical protein; Provisional; Region: PRK06208 56107007575 intersubunit interface [polypeptide binding]; other site 56107007576 active site 56107007577 Zn2+ binding site [ion binding]; other site 56107007578 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107007579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107007580 Probable transposase; Region: OrfB_IS605; pfam01385 56107007581 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107007582 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 56107007583 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 56107007584 putative active site [active] 56107007585 catalytic site [active] 56107007586 putative metal binding site [ion binding]; other site 56107007587 von Willebrand factor type A domain; Region: VWA_2; pfam13519 56107007588 metal ion-dependent adhesion site (MIDAS); other site 56107007589 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 56107007590 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 56107007591 nucleotide binding pocket [chemical binding]; other site 56107007592 K-X-D-G motif; other site 56107007593 catalytic site [active] 56107007594 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 56107007595 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 56107007596 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 56107007597 Dimer interface [polypeptide binding]; other site 56107007598 Response regulator receiver domain; Region: Response_reg; pfam00072 56107007599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107007600 active site 56107007601 phosphorylation site [posttranslational modification] 56107007602 intermolecular recognition site; other site 56107007603 dimerization interface [polypeptide binding]; other site 56107007604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107007605 ATP binding site [chemical binding]; other site 56107007606 Mg2+ binding site [ion binding]; other site 56107007607 G-X-G motif; other site 56107007608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107007609 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107007610 putative active site [active] 56107007611 heme pocket [chemical binding]; other site 56107007612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107007613 putative active site [active] 56107007614 heme pocket [chemical binding]; other site 56107007615 PAS fold; Region: PAS_4; pfam08448 56107007616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107007617 putative active site [active] 56107007618 heme pocket [chemical binding]; other site 56107007619 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107007620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107007621 putative active site [active] 56107007622 heme pocket [chemical binding]; other site 56107007623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107007624 dimer interface [polypeptide binding]; other site 56107007625 phosphorylation site [posttranslational modification] 56107007626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107007627 ATP binding site [chemical binding]; other site 56107007628 Mg2+ binding site [ion binding]; other site 56107007629 G-X-G motif; other site 56107007630 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107007631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107007632 active site 56107007633 phosphorylation site [posttranslational modification] 56107007634 intermolecular recognition site; other site 56107007635 dimerization interface [polypeptide binding]; other site 56107007636 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 56107007637 Fasciclin domain; Region: Fasciclin; pfam02469 56107007638 EamA-like transporter family; Region: EamA; pfam00892 56107007639 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 56107007640 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 56107007641 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 56107007642 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 56107007643 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 56107007644 RNA binding site [nucleotide binding]; other site 56107007645 active site 56107007646 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 56107007647 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 56107007648 Cytochrome P450; Region: p450; pfam00067 56107007649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107007650 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107007651 Probable transposase; Region: OrfB_IS605; pfam01385 56107007652 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107007653 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 56107007654 substrate binding pocket [chemical binding]; other site 56107007655 substrate-Mg2+ binding site; other site 56107007656 aspartate-rich region 1; other site 56107007657 aspartate-rich region 2; other site 56107007658 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 56107007659 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 56107007660 N-terminal plug; other site 56107007661 ligand-binding site [chemical binding]; other site 56107007662 cytochrome c6; Provisional; Region: PRK13697 56107007663 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 56107007664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107007665 Coenzyme A binding pocket [chemical binding]; other site 56107007666 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 56107007667 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 56107007668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 56107007669 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 56107007670 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 56107007671 DNA binding residues [nucleotide binding] 56107007672 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107007673 primosomal protein N' Region: priA; TIGR00595 56107007674 ATP binding site [chemical binding]; other site 56107007675 putative Mg++ binding site [ion binding]; other site 56107007676 helicase superfamily c-terminal domain; Region: HELICc; smart00490 56107007677 Red chlorophyll catabolite reductase (RCC reductase); Region: RCC_reductase; cl05747 56107007678 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 56107007679 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107007680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107007681 active site 56107007682 phosphorylation site [posttranslational modification] 56107007683 intermolecular recognition site; other site 56107007684 dimerization interface [polypeptide binding]; other site 56107007685 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107007686 DNA binding residues [nucleotide binding] 56107007687 dimerization interface [polypeptide binding]; other site 56107007688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107007689 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 56107007690 dimer interface [polypeptide binding]; other site 56107007691 phosphorylation site [posttranslational modification] 56107007692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107007693 ATP binding site [chemical binding]; other site 56107007694 Mg2+ binding site [ion binding]; other site 56107007695 G-X-G motif; other site 56107007696 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 56107007697 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 56107007698 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 56107007699 Soluble P-type ATPase [General function prediction only]; Region: COG4087 56107007700 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 56107007701 potassium-transporting ATPase subunit C; Provisional; Region: PRK14003 56107007702 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 56107007703 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 56107007704 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 56107007705 Ligand Binding Site [chemical binding]; other site 56107007706 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 56107007707 Transposase; Region: HTH_Tnp_IS630; pfam01710 56107007708 Homeodomain-like domain; Region: HTH_32; pfam13565 56107007709 Winged helix-turn helix; Region: HTH_33; pfam13592 56107007710 DDE superfamily endonuclease; Region: DDE_3; pfam13358 56107007711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 56107007712 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 56107007713 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 56107007714 active site 56107007715 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 56107007716 ABC1 family; Region: ABC1; cl17513 56107007717 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 56107007718 Predicted transcriptional regulator [Transcription]; Region: COG3905 56107007719 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107007720 putative active site [active] 56107007721 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107007722 putative active site [active] 56107007723 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 56107007724 DHH family; Region: DHH; pfam01368 56107007725 FOG: CBS domain [General function prediction only]; Region: COG0517 56107007726 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 56107007727 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 56107007728 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 56107007729 active site 56107007730 NTP binding site [chemical binding]; other site 56107007731 metal binding triad [ion binding]; metal-binding site 56107007732 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 56107007733 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 56107007734 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 56107007735 homopentamer interface [polypeptide binding]; other site 56107007736 active site 56107007737 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 56107007738 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 56107007739 putative catalytic cysteine [active] 56107007740 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 56107007741 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 56107007742 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107007743 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 56107007744 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 56107007745 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 56107007746 putative di-iron ligands [ion binding]; other site 56107007747 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 56107007748 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 56107007749 putative di-iron ligands [ion binding]; other site 56107007750 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 56107007751 Fatty acid desaturase; Region: FA_desaturase; pfam00487 56107007752 Di-iron ligands [ion binding]; other site 56107007753 Aluminium resistance protein; Region: Alum_res; pfam06838 56107007754 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 56107007755 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 56107007756 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 56107007757 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 56107007758 Uncharacterized conserved protein [Function unknown]; Region: COG1479 56107007759 Protein of unknown function DUF262; Region: DUF262; pfam03235 56107007760 Divergent AAA domain; Region: AAA_4; pfam04326 56107007761 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107007762 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107007763 active site 56107007764 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 56107007765 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107007766 putative active site [active] 56107007767 16S rRNA methyltransferase B; Provisional; Region: PRK14901 56107007768 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 56107007769 putative RNA binding site [nucleotide binding]; other site 56107007770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107007771 S-adenosylmethionine binding site [chemical binding]; other site 56107007772 tellurium resistance terB-like protein; Region: terB_like; cd07177 56107007773 metal binding site [ion binding]; metal-binding site 56107007774 Transglycosylase; Region: Transgly; pfam00912 56107007775 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 56107007776 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 56107007777 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 56107007778 catalytic center binding site [active] 56107007779 ATP binding site [chemical binding]; other site 56107007780 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 56107007781 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 56107007782 dimer interface [polypeptide binding]; other site 56107007783 ADP-ribose binding site [chemical binding]; other site 56107007784 active site 56107007785 nudix motif; other site 56107007786 metal binding site [ion binding]; metal-binding site 56107007787 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 56107007788 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 56107007789 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 56107007790 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 56107007791 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 56107007792 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 56107007793 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 56107007794 active site 56107007795 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 56107007796 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 56107007797 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 56107007798 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 56107007799 Cadmium resistance transporter; Region: Cad; pfam03596 56107007800 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 56107007801 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 56107007802 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 56107007803 Cadmium resistance transporter; Region: Cad; pfam03596 56107007804 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 56107007805 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 56107007806 dimer interface [polypeptide binding]; other site 56107007807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107007808 catalytic residue [active] 56107007809 Predicted transcriptional regulator [Transcription]; Region: COG1959 56107007810 Transcriptional regulator; Region: Rrf2; pfam02082 56107007811 serine O-acetyltransferase; Region: cysE; TIGR01172 56107007812 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 56107007813 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 56107007814 trimer interface [polypeptide binding]; other site 56107007815 active site 56107007816 substrate binding site [chemical binding]; other site 56107007817 CoA binding site [chemical binding]; other site 56107007818 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 56107007819 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 56107007820 Walker A/P-loop; other site 56107007821 ATP binding site [chemical binding]; other site 56107007822 Q-loop/lid; other site 56107007823 ABC transporter signature motif; other site 56107007824 Walker B; other site 56107007825 D-loop; other site 56107007826 H-loop/switch region; other site 56107007827 TOBE-like domain; Region: TOBE_3; pfam12857 56107007828 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107007829 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 56107007830 putative switch regulator; other site 56107007831 non-specific DNA interactions [nucleotide binding]; other site 56107007832 DNA binding site [nucleotide binding] 56107007833 sequence specific DNA binding site [nucleotide binding]; other site 56107007834 putative cAMP binding site [chemical binding]; other site 56107007835 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 56107007836 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 56107007837 NIL domain; Region: NIL; pfam09383 56107007838 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14258 56107007839 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 56107007840 Walker A/P-loop; other site 56107007841 ATP binding site [chemical binding]; other site 56107007842 Q-loop/lid; other site 56107007843 ABC transporter signature motif; other site 56107007844 Walker B; other site 56107007845 D-loop; other site 56107007846 H-loop/switch region; other site 56107007847 putative cation:proton antiport protein; Provisional; Region: PRK10669 56107007848 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 56107007849 TrkA-N domain; Region: TrkA_N; pfam02254 56107007850 aspartate kinase; Provisional; Region: PRK07431 56107007851 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 56107007852 putative nucleotide binding site [chemical binding]; other site 56107007853 putative catalytic residues [active] 56107007854 putative Mg ion binding site [ion binding]; other site 56107007855 putative aspartate binding site [chemical binding]; other site 56107007856 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 56107007857 putative allosteric regulatory site; other site 56107007858 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 56107007859 putative allosteric regulatory residue; other site 56107007860 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 56107007861 putative allosteric regulatory site; other site 56107007862 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 56107007863 putative allosteric regulatory residue; other site 56107007864 hypothetical protein; Provisional; Region: PRK02237 56107007865 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 56107007866 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107007867 putative active site [active] 56107007868 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107007869 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107007870 active site 56107007871 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107007872 putative active site [active] 56107007873 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 56107007874 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 56107007875 Walker A/P-loop; other site 56107007876 ATP binding site [chemical binding]; other site 56107007877 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 56107007878 Prefoldin subunit; Region: Prefoldin_2; pfam01920 56107007879 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 56107007880 ABC transporter signature motif; other site 56107007881 Walker B; other site 56107007882 D-loop; other site 56107007883 H-loop/switch region; other site 56107007884 PRC-barrel domain; Region: PRC; pfam05239 56107007885 PRC-barrel domain; Region: PRC; pfam05239 56107007886 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107007887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107007888 binding surface 56107007889 TPR motif; other site 56107007890 TPR repeat; Region: TPR_11; pfam13414 56107007891 TPR repeat; Region: TPR_11; pfam13414 56107007892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107007893 binding surface 56107007894 TPR motif; other site 56107007895 TPR repeat; Region: TPR_11; pfam13414 56107007896 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 56107007897 putative active site [active] 56107007898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107007899 TPR motif; other site 56107007900 binding surface 56107007901 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107007902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 56107007903 Bacterial SH3 domain; Region: SH3_3; pfam08239 56107007904 Bacterial SH3 domain; Region: SH3_3; pfam08239 56107007905 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 56107007906 von Willebrand factor type A domain; Region: VWA_2; pfam13519 56107007907 metal ion-dependent adhesion site (MIDAS); other site 56107007908 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107007909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107007910 active site 56107007911 phosphorylation site [posttranslational modification] 56107007912 intermolecular recognition site; other site 56107007913 dimerization interface [polypeptide binding]; other site 56107007914 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107007915 DNA binding site [nucleotide binding] 56107007916 Hpt domain; Region: Hpt; pfam01627 56107007917 putative binding surface; other site 56107007918 active site 56107007919 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107007920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107007921 active site 56107007922 phosphorylation site [posttranslational modification] 56107007923 intermolecular recognition site; other site 56107007924 dimerization interface [polypeptide binding]; other site 56107007925 circadian clock protein KaiC; Reviewed; Region: PRK09302 56107007926 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 56107007927 Walker A motif; other site 56107007928 ATP binding site [chemical binding]; other site 56107007929 Walker B motif; other site 56107007930 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 56107007931 Walker A motif; other site 56107007932 ATP binding site [chemical binding]; other site 56107007933 Walker B motif; other site 56107007934 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 56107007935 tetramer interface [polypeptide binding]; other site 56107007936 dimer interface [polypeptide binding]; other site 56107007937 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 56107007938 tetramer interface [polypeptide binding]; other site 56107007939 dimer interface [polypeptide binding]; other site 56107007940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107007941 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107007942 putative active site [active] 56107007943 heme pocket [chemical binding]; other site 56107007944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107007945 PAS domain; Region: PAS_9; pfam13426 56107007946 putative active site [active] 56107007947 heme pocket [chemical binding]; other site 56107007948 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107007949 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107007950 putative active site [active] 56107007951 heme pocket [chemical binding]; other site 56107007952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107007953 dimer interface [polypeptide binding]; other site 56107007954 phosphorylation site [posttranslational modification] 56107007955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107007956 ATP binding site [chemical binding]; other site 56107007957 Mg2+ binding site [ion binding]; other site 56107007958 G-X-G motif; other site 56107007959 Response regulator receiver domain; Region: Response_reg; pfam00072 56107007960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107007961 active site 56107007962 phosphorylation site [posttranslational modification] 56107007963 intermolecular recognition site; other site 56107007964 dimerization interface [polypeptide binding]; other site 56107007965 Predicted membrane protein [Function unknown]; Region: COG4327 56107007966 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 56107007967 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 56107007968 Na binding site [ion binding]; other site 56107007969 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107007970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107007971 binding surface 56107007972 TPR motif; other site 56107007973 TPR repeat; Region: TPR_11; pfam13414 56107007974 TPR repeat; Region: TPR_11; pfam13414 56107007975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107007976 binding surface 56107007977 TPR motif; other site 56107007978 TPR repeat; Region: TPR_11; pfam13414 56107007979 TPR repeat; Region: TPR_11; pfam13414 56107007980 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 56107007981 catalytic site [active] 56107007982 putative active site [active] 56107007983 putative substrate binding site [chemical binding]; other site 56107007984 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 56107007985 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 56107007986 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 56107007987 DNA binding site [nucleotide binding] 56107007988 active site 56107007989 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 56107007990 Fatty acid desaturase; Region: FA_desaturase; pfam00487 56107007991 Di-iron ligands [ion binding]; other site 56107007992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 56107007993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 56107007994 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107007995 catalytic residues [active] 56107007996 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 56107007997 Prostaglandin dehydrogenases; Region: PGDH; cd05288 56107007998 NAD(P) binding site [chemical binding]; other site 56107007999 substrate binding site [chemical binding]; other site 56107008000 dimer interface [polypeptide binding]; other site 56107008001 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 56107008002 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 56107008003 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 56107008004 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107008005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107008006 binding surface 56107008007 TPR motif; other site 56107008008 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107008009 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107008010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107008011 binding surface 56107008012 TPR motif; other site 56107008013 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107008014 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107008015 CHAT domain; Region: CHAT; pfam12770 56107008016 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 56107008017 endonuclease III; Region: ENDO3c; smart00478 56107008018 minor groove reading motif; other site 56107008019 helix-hairpin-helix signature motif; other site 56107008020 substrate binding pocket [chemical binding]; other site 56107008021 active site 56107008022 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 56107008023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107008024 Coenzyme A binding pocket [chemical binding]; other site 56107008025 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 56107008026 Amidinotransferase; Region: Amidinotransf; cl12043 56107008027 Uncharacterized conserved protein [Function unknown]; Region: COG1915 56107008028 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 56107008029 homodimer interface [polypeptide binding]; other site 56107008030 Bacterial SH3 domain; Region: SH3_3; pfam08239 56107008031 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 56107008032 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 56107008033 active site 56107008034 metal binding site [ion binding]; metal-binding site 56107008035 CTP synthetase; Validated; Region: pyrG; PRK05380 56107008036 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 56107008037 Catalytic site [active] 56107008038 active site 56107008039 UTP binding site [chemical binding]; other site 56107008040 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 56107008041 active site 56107008042 putative oxyanion hole; other site 56107008043 catalytic triad [active] 56107008044 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 56107008045 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 56107008046 nucleotide binding site [chemical binding]; other site 56107008047 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 56107008048 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 56107008049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107008050 dimer interface [polypeptide binding]; other site 56107008051 conserved gate region; other site 56107008052 ABC-ATPase subunit interface; other site 56107008053 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 56107008054 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 56107008055 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 56107008056 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 56107008057 catalytic residues [active] 56107008058 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107008059 putative active site [active] 56107008060 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 56107008061 Tetratricopeptide repeat; Region: TPR_16; pfam13432 56107008062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 56107008063 TPR motif; other site 56107008064 binding surface 56107008065 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 56107008066 Transposase IS200 like; Region: Y1_Tnp; cl00848 56107008067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107008068 binding surface 56107008069 Tetratricopeptide repeat; Region: TPR_16; pfam13432 56107008070 TPR motif; other site 56107008071 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 56107008072 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107008073 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107008074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 56107008075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 56107008076 Methyltransferase domain; Region: Methyltransf_24; pfam13578 56107008077 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 56107008078 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 56107008079 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 56107008080 phosphopeptide binding site; other site 56107008081 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 56107008082 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107008083 active site 56107008084 ATP binding site [chemical binding]; other site 56107008085 substrate binding site [chemical binding]; other site 56107008086 activation loop (A-loop); other site 56107008087 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 56107008088 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 56107008089 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 56107008090 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 56107008091 active site 56107008092 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 56107008093 pseudouridine synthase; Region: TIGR00093 56107008094 probable active site [active] 56107008095 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107008096 putative active site [active] 56107008097 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 56107008098 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 56107008099 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 56107008100 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 56107008101 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 56107008102 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 56107008103 oligomeric interface; other site 56107008104 putative active site [active] 56107008105 homodimer interface [polypeptide binding]; other site 56107008106 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 56107008107 heme-binding site [chemical binding]; other site 56107008108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 56107008109 active site 56107008110 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 56107008111 Domain of unknown function DUF21; Region: DUF21; pfam01595 56107008112 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 56107008113 Transporter associated domain; Region: CorC_HlyC; smart01091 56107008114 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 56107008115 Ligand Binding Site [chemical binding]; other site 56107008116 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 56107008117 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 56107008118 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 56107008119 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 56107008120 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 56107008121 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 56107008122 Mg binding site [ion binding]; other site 56107008123 nucleotide binding site [chemical binding]; other site 56107008124 putative protofilament interface [polypeptide binding]; other site 56107008125 CAAX protease self-immunity; Region: Abi; pfam02517 56107008126 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 56107008127 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 56107008128 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 56107008129 catalytic loop [active] 56107008130 iron binding site [ion binding]; other site 56107008131 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 56107008132 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 56107008133 substrate binding site [chemical binding]; other site 56107008134 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 56107008135 substrate binding site [chemical binding]; other site 56107008136 ligand binding site [chemical binding]; other site 56107008137 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 56107008138 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107008139 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 56107008140 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 56107008141 ATP-grasp domain; Region: ATP-grasp_4; cl17255 56107008142 EamA-like transporter family; Region: EamA; pfam00892 56107008143 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 56107008144 Spindle and kinetochore-associated protein 2; Region: SKA2; cd12955 56107008145 SKA1 interface [polypeptide binding]; other site 56107008146 SKA3 interface [polypeptide binding]; other site 56107008147 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 56107008148 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 56107008149 active site 56107008150 metal binding site [ion binding]; metal-binding site 56107008151 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 56107008152 DNA primase; Validated; Region: dnaG; PRK05667 56107008153 CHC2 zinc finger; Region: zf-CHC2; pfam01807 56107008154 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 56107008155 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 56107008156 active site 56107008157 metal binding site [ion binding]; metal-binding site 56107008158 interdomain interaction site; other site 56107008159 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 56107008160 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107008161 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107008162 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107008163 hypothetical protein; Reviewed; Region: PRK12497 56107008164 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 56107008165 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 56107008166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107008167 binding surface 56107008168 TPR motif; other site 56107008169 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107008170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107008171 binding surface 56107008172 TPR motif; other site 56107008173 TPR repeat; Region: TPR_11; pfam13414 56107008174 TPR repeat; Region: TPR_11; pfam13414 56107008175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107008176 binding surface 56107008177 TPR motif; other site 56107008178 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 56107008179 TrkA-N domain; Region: TrkA_N; pfam02254 56107008180 TrkA-C domain; Region: TrkA_C; pfam02080 56107008181 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 56107008182 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 56107008183 tocopherol O-methyltransferase; Region: PLN02244 56107008184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107008185 S-adenosylmethionine binding site [chemical binding]; other site 56107008186 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 56107008187 UbiA prenyltransferase family; Region: UbiA; pfam01040 56107008188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107008189 binding surface 56107008190 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 56107008191 TPR motif; other site 56107008192 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 56107008193 active site 56107008194 SAM binding site [chemical binding]; other site 56107008195 homodimer interface [polypeptide binding]; other site 56107008196 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 56107008197 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 56107008198 active site 56107008199 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 56107008200 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 56107008201 CoA-binding site [chemical binding]; other site 56107008202 ATP-binding [chemical binding]; other site 56107008203 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 56107008204 DNA photolyase; Region: DNA_photolyase; pfam00875 56107008205 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 56107008206 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 56107008207 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 56107008208 catalytic triad [active] 56107008209 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 56107008210 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 56107008211 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 56107008212 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 56107008213 catalytic residue [active] 56107008214 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 56107008215 proposed catalytic triad [active] 56107008216 active site nucleophile [active] 56107008217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107008218 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107008219 Probable transposase; Region: OrfB_IS605; pfam01385 56107008220 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107008221 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 56107008222 proposed catalytic triad [active] 56107008223 active site nucleophile [active] 56107008224 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 56107008225 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 56107008226 active site 56107008227 catalytic site [active] 56107008228 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107008229 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107008230 GTP-binding protein LepA; Provisional; Region: PRK05433 56107008231 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 56107008232 G1 box; other site 56107008233 putative GEF interaction site [polypeptide binding]; other site 56107008234 GTP/Mg2+ binding site [chemical binding]; other site 56107008235 Switch I region; other site 56107008236 G2 box; other site 56107008237 G3 box; other site 56107008238 Switch II region; other site 56107008239 G4 box; other site 56107008240 G5 box; other site 56107008241 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 56107008242 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 56107008243 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 56107008244 GAF domain; Region: GAF_3; pfam13492 56107008245 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107008246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107008247 dimer interface [polypeptide binding]; other site 56107008248 phosphorylation site [posttranslational modification] 56107008249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107008250 ATP binding site [chemical binding]; other site 56107008251 Mg2+ binding site [ion binding]; other site 56107008252 G-X-G motif; other site 56107008253 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 56107008254 NifU-like domain; Region: NifU; pfam01106 56107008255 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 56107008256 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 56107008257 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 56107008258 putative active site [active] 56107008259 catalytic site [active] 56107008260 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 56107008261 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 56107008262 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107008263 active site 56107008264 ATP binding site [chemical binding]; other site 56107008265 substrate binding site [chemical binding]; other site 56107008266 activation loop (A-loop); other site 56107008267 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107008268 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107008269 active site 56107008270 ATP binding site [chemical binding]; other site 56107008271 substrate binding site [chemical binding]; other site 56107008272 activation loop (A-loop); other site 56107008273 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107008274 structural tetrad; other site 56107008275 PQQ-like domain; Region: PQQ_2; pfam13360 56107008276 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107008277 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107008278 ligand binding site [chemical binding]; other site 56107008279 flexible hinge region; other site 56107008280 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 56107008281 Response regulator receiver domain; Region: Response_reg; pfam00072 56107008282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107008283 active site 56107008284 phosphorylation site [posttranslational modification] 56107008285 intermolecular recognition site; other site 56107008286 dimerization interface [polypeptide binding]; other site 56107008287 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 56107008288 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 56107008289 Cl- selectivity filter; other site 56107008290 Cl- binding residues [ion binding]; other site 56107008291 pore gating glutamate residue; other site 56107008292 dimer interface [polypeptide binding]; other site 56107008293 H+/Cl- coupling transport residue; other site 56107008294 FOG: CBS domain [General function prediction only]; Region: COG0517 56107008295 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 56107008296 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 56107008297 Ligand Binding Site [chemical binding]; other site 56107008298 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 56107008299 Ligand Binding Site [chemical binding]; other site 56107008300 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 56107008301 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 56107008302 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 56107008303 CAS motifs; other site 56107008304 active site 56107008305 Protein of unknown function (DUF561); Region: DUF561; pfam04481 56107008306 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 56107008307 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 56107008308 inhibitor-cofactor binding pocket; inhibition site 56107008309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107008310 catalytic residue [active] 56107008311 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 56107008312 YGGT family; Region: YGGT; pfam02325 56107008313 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 56107008314 active site 56107008315 carotene isomerase; Region: carot_isom; TIGR02730 56107008316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107008317 hydroxyglutarate oxidase; Provisional; Region: PRK11728 56107008318 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107008319 Tetratricopeptide repeat; Region: TPR_10; pfam13374 56107008320 Tetratricopeptide repeat; Region: TPR_10; pfam13374 56107008321 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107008322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107008323 binding surface 56107008324 TPR motif; other site 56107008325 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107008326 Tetratricopeptide repeat; Region: TPR_10; pfam13374 56107008327 CHAT domain; Region: CHAT; cl17868 56107008328 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 56107008329 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 56107008330 AMIN domain; Region: AMIN; pfam11741 56107008331 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 56107008332 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 56107008333 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 56107008334 ATP-grasp domain; Region: ATP-grasp; pfam02222 56107008335 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107008336 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107008337 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107008338 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 56107008339 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 56107008340 putative dimer interface [polypeptide binding]; other site 56107008341 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 56107008342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107008343 Walker A motif; other site 56107008344 ATP binding site [chemical binding]; other site 56107008345 arginine finger; other site 56107008346 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 56107008347 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 56107008348 nudix motif; other site 56107008349 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 56107008350 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 56107008351 tetramer interface [polypeptide binding]; other site 56107008352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107008353 catalytic residue [active] 56107008354 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 56107008355 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 56107008356 dimerization interface [polypeptide binding]; other site 56107008357 DPS ferroxidase diiron center [ion binding]; other site 56107008358 ion pore; other site 56107008359 ChaB; Region: ChaB; pfam06150 56107008360 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 56107008361 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 56107008362 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 56107008363 aromatic amino acid transport protein; Region: araaP; TIGR00837 56107008364 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 56107008365 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 56107008366 NodB motif; other site 56107008367 active site 56107008368 catalytic site [active] 56107008369 metal binding site [ion binding]; metal-binding site 56107008370 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107008371 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107008372 active site 56107008373 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107008374 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 56107008375 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107008376 GAF domain; Region: GAF; pfam01590 56107008377 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107008378 GAF domain; Region: GAF; pfam01590 56107008379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107008380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107008381 dimer interface [polypeptide binding]; other site 56107008382 phosphorylation site [posttranslational modification] 56107008383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107008384 ATP binding site [chemical binding]; other site 56107008385 Mg2+ binding site [ion binding]; other site 56107008386 G-X-G motif; other site 56107008387 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 56107008388 putative hydrophobic ligand binding site [chemical binding]; other site 56107008389 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 56107008390 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 56107008391 TrkA-N domain; Region: TrkA_N; pfam02254 56107008392 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 56107008393 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 56107008394 intrachain domain interface; other site 56107008395 heme bH binding site [chemical binding]; other site 56107008396 heme bL binding site [chemical binding]; other site 56107008397 interchain domain interface [polypeptide binding]; other site 56107008398 Qo binding site; other site 56107008399 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 56107008400 PGAP1-like protein; Region: PGAP1; pfam07819 56107008401 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 56107008402 Cytochrome c; Region: Cytochrom_C; cl11414 56107008403 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 56107008404 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 56107008405 plastocyanin; Provisional; Region: PRK02710 56107008406 cytochrome c-550; Provisional; Region: psbV; cl17239 56107008407 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 56107008408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107008409 dimer interface [polypeptide binding]; other site 56107008410 conserved gate region; other site 56107008411 putative PBP binding loops; other site 56107008412 ABC-ATPase subunit interface; other site 56107008413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107008414 dimer interface [polypeptide binding]; other site 56107008415 conserved gate region; other site 56107008416 putative PBP binding loops; other site 56107008417 ABC-ATPase subunit interface; other site 56107008418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107008419 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 56107008420 Walker A motif; other site 56107008421 ATP binding site [chemical binding]; other site 56107008422 Walker B motif; other site 56107008423 arginine finger; other site 56107008424 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 56107008425 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 56107008426 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 56107008427 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 56107008428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 56107008429 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 56107008430 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 56107008431 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 56107008432 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 56107008433 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 56107008434 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 56107008435 tartrate dehydrogenase; Region: TTC; TIGR02089 56107008436 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 56107008437 Mechanosensitive ion channel; Region: MS_channel; pfam00924 56107008438 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 56107008439 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 56107008440 Walker A/P-loop; other site 56107008441 ATP binding site [chemical binding]; other site 56107008442 Q-loop/lid; other site 56107008443 ABC transporter signature motif; other site 56107008444 Walker B; other site 56107008445 D-loop; other site 56107008446 H-loop/switch region; other site 56107008447 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 56107008448 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 56107008449 elongation factor Ts; Reviewed; Region: tsf; PRK12332 56107008450 UBA/TS-N domain; Region: UBA; pfam00627 56107008451 Elongation factor TS; Region: EF_TS; pfam00889 56107008452 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107008453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107008454 active site 56107008455 phosphorylation site [posttranslational modification] 56107008456 intermolecular recognition site; other site 56107008457 dimerization interface [polypeptide binding]; other site 56107008458 Response regulator receiver domain; Region: Response_reg; pfam00072 56107008459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107008460 active site 56107008461 phosphorylation site [posttranslational modification] 56107008462 intermolecular recognition site; other site 56107008463 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107008464 dimerization interface [polypeptide binding]; other site 56107008465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107008466 dimer interface [polypeptide binding]; other site 56107008467 phosphorylation site [posttranslational modification] 56107008468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107008469 ATP binding site [chemical binding]; other site 56107008470 Mg2+ binding site [ion binding]; other site 56107008471 G-X-G motif; other site 56107008472 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107008473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107008474 active site 56107008475 phosphorylation site [posttranslational modification] 56107008476 intermolecular recognition site; other site 56107008477 dimerization interface [polypeptide binding]; other site 56107008478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107008479 dimer interface [polypeptide binding]; other site 56107008480 phosphorylation site [posttranslational modification] 56107008481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107008482 ATP binding site [chemical binding]; other site 56107008483 Mg2+ binding site [ion binding]; other site 56107008484 G-X-G motif; other site 56107008485 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107008486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107008487 active site 56107008488 phosphorylation site [posttranslational modification] 56107008489 intermolecular recognition site; other site 56107008490 dimerization interface [polypeptide binding]; other site 56107008491 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107008492 DNA binding residues [nucleotide binding] 56107008493 dimerization interface [polypeptide binding]; other site 56107008494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 56107008495 conserved hypothetical protein; Region: TIGR03492 56107008496 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 56107008497 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 56107008498 Surface antigen; Region: Bac_surface_Ag; pfam01103 56107008499 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107008500 active site 56107008501 ATP binding site [chemical binding]; other site 56107008502 substrate binding site [chemical binding]; other site 56107008503 activation loop (A-loop); other site 56107008504 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 56107008505 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 56107008506 putative active site [active] 56107008507 putative metal binding site [ion binding]; other site 56107008508 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 56107008509 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 56107008510 hydrophobic ligand binding site; other site 56107008511 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 56107008512 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 56107008513 Clp amino terminal domain; Region: Clp_N; pfam02861 56107008514 Clp amino terminal domain; Region: Clp_N; pfam02861 56107008515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107008516 Walker A motif; other site 56107008517 ATP binding site [chemical binding]; other site 56107008518 Walker B motif; other site 56107008519 arginine finger; other site 56107008520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107008521 Walker A motif; other site 56107008522 ATP binding site [chemical binding]; other site 56107008523 Walker B motif; other site 56107008524 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 56107008525 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 56107008526 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 56107008527 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 56107008528 P-loop; other site 56107008529 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 56107008530 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 56107008531 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 56107008532 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 56107008533 Putative catalytic domain of uncharacterized hypothetical proteins closely related to Nuc, , an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar2; cd09174 56107008534 PLD-like domain; Region: PLDc_2; pfam13091 56107008535 putative active site [active] 56107008536 catalytic site [active] 56107008537 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 56107008538 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 56107008539 Walker A/P-loop; other site 56107008540 ATP binding site [chemical binding]; other site 56107008541 Q-loop/lid; other site 56107008542 ABC transporter signature motif; other site 56107008543 Walker B; other site 56107008544 D-loop; other site 56107008545 H-loop/switch region; other site 56107008546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107008547 dimer interface [polypeptide binding]; other site 56107008548 conserved gate region; other site 56107008549 putative PBP binding loops; other site 56107008550 ABC-ATPase subunit interface; other site 56107008551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107008552 dimer interface [polypeptide binding]; other site 56107008553 conserved gate region; other site 56107008554 putative PBP binding loops; other site 56107008555 ABC-ATPase subunit interface; other site 56107008556 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 56107008557 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107008558 substrate binding pocket [chemical binding]; other site 56107008559 membrane-bound complex binding site; other site 56107008560 hinge residues; other site 56107008561 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 56107008562 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 56107008563 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 56107008564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107008565 FeS/SAM binding site; other site 56107008566 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 56107008567 anti sigma factor interaction site; other site 56107008568 regulatory phosphorylation site [posttranslational modification]; other site 56107008569 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 56107008570 Bacterial sugar transferase; Region: Bac_transf; pfam02397 56107008571 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 56107008572 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 56107008573 L-asparaginase II; Region: Asparaginase_II; cl01842 56107008574 Protein of unknown function (DUF3257); Region: DUF3257; pfam11645 56107008575 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 56107008576 G1 box; other site 56107008577 GTP/Mg2+ binding site [chemical binding]; other site 56107008578 G3 box; other site 56107008579 Switch II region; other site 56107008580 G4 box; other site 56107008581 Domain of unknown function (DUF697); Region: DUF697; pfam05128 56107008582 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 56107008583 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 56107008584 folate binding site [chemical binding]; other site 56107008585 NADP+ binding site [chemical binding]; other site 56107008586 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 56107008587 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 56107008588 cofactor binding site; other site 56107008589 DNA binding site [nucleotide binding] 56107008590 substrate interaction site [chemical binding]; other site 56107008591 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 56107008592 intersubunit interface [polypeptide binding]; other site 56107008593 active site 56107008594 catalytic residue [active] 56107008595 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 56107008596 Recombination protein O N terminal; Region: RecO_N; pfam11967 56107008597 Recombination protein O C terminal; Region: RecO_C; pfam02565 56107008598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107008599 H+ Antiporter protein; Region: 2A0121; TIGR00900 56107008600 putative substrate translocation pore; other site 56107008601 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107008602 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107008603 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 56107008604 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 56107008605 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107008606 putative active site [active] 56107008607 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107008608 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 56107008609 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 56107008610 active site 56107008611 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 56107008612 phosphoglyceromutase; Provisional; Region: PRK05434 56107008613 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 56107008614 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 56107008615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107008616 Walker A/P-loop; other site 56107008617 ATP binding site [chemical binding]; other site 56107008618 Q-loop/lid; other site 56107008619 ABC transporter signature motif; other site 56107008620 Walker B; other site 56107008621 D-loop; other site 56107008622 H-loop/switch region; other site 56107008623 ABC transporter; Region: ABC_tran_2; pfam12848 56107008624 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 56107008625 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107008626 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 56107008627 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 56107008628 Methyltransferase domain; Region: Methyltransf_26; pfam13659 56107008629 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107008630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107008631 non-specific DNA binding site [nucleotide binding]; other site 56107008632 salt bridge; other site 56107008633 sequence-specific DNA binding site [nucleotide binding]; other site 56107008634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107008635 non-specific DNA binding site [nucleotide binding]; other site 56107008636 salt bridge; other site 56107008637 sequence-specific DNA binding site [nucleotide binding]; other site 56107008638 peptide chain release factor 1; Validated; Region: prfA; PRK00591 56107008639 This domain is found in peptide chain release factors; Region: PCRF; smart00937 56107008640 RF-1 domain; Region: RF-1; pfam00472 56107008641 ribosomal protein L31; Validated; Region: rpl31; CHL00136 56107008642 ribosomal protein S9; Region: rps9; CHL00079 56107008643 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 56107008644 23S rRNA interface [nucleotide binding]; other site 56107008645 L3 interface [polypeptide binding]; other site 56107008646 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 56107008647 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 56107008648 dimerization interface 3.5A [polypeptide binding]; other site 56107008649 active site 56107008650 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 56107008651 RNA polymerase alpha subunit; Region: rpoA; CHL00013 56107008652 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 56107008653 alphaNTD - beta interaction site [polypeptide binding]; other site 56107008654 alphaNTD homodimer interface [polypeptide binding]; other site 56107008655 alphaNTD - beta' interaction site [polypeptide binding]; other site 56107008656 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 56107008657 30S ribosomal protein S11; Validated; Region: PRK05309 56107008658 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 56107008659 30S ribosomal protein S13; Region: bact_S13; TIGR03631 56107008660 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 56107008661 rRNA binding site [nucleotide binding]; other site 56107008662 predicted 30S ribosome binding site; other site 56107008663 adenylate kinase; Provisional; Region: adk; PRK02496 56107008664 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 56107008665 AMP-binding site [chemical binding]; other site 56107008666 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 56107008667 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 56107008668 SecY translocase; Region: SecY; pfam00344 56107008669 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 56107008670 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 56107008671 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 56107008672 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 56107008673 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 56107008674 5S rRNA interface [nucleotide binding]; other site 56107008675 L27 interface [polypeptide binding]; other site 56107008676 23S rRNA interface [nucleotide binding]; other site 56107008677 L5 interface [polypeptide binding]; other site 56107008678 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 56107008679 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 56107008680 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 56107008681 ribosomal protein S8; Region: rps8; CHL00042 56107008682 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 56107008683 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 56107008684 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 56107008685 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 56107008686 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 56107008687 RNA binding site [nucleotide binding]; other site 56107008688 ribosomal protein L14; Region: rpl14; CHL00057 56107008689 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 56107008690 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 56107008691 23S rRNA interface [nucleotide binding]; other site 56107008692 putative translocon interaction site; other site 56107008693 signal recognition particle (SRP54) interaction site; other site 56107008694 L23 interface [polypeptide binding]; other site 56107008695 trigger factor interaction site; other site 56107008696 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 56107008697 23S rRNA interface [nucleotide binding]; other site 56107008698 5S rRNA interface [nucleotide binding]; other site 56107008699 putative antibiotic binding site [chemical binding]; other site 56107008700 L25 interface [polypeptide binding]; other site 56107008701 L27 interface [polypeptide binding]; other site 56107008702 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 56107008703 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 56107008704 G-X-X-G motif; other site 56107008705 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 56107008706 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 56107008707 putative translocon binding site; other site 56107008708 protein-rRNA interface [nucleotide binding]; other site 56107008709 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 56107008710 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 56107008711 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 56107008712 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 56107008713 ribosomal protein L23; Region: rpl23; CHL00030 56107008714 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 56107008715 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 56107008716 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 56107008717 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107008718 putative active site [active] 56107008719 NB-ARC domain; Region: NB-ARC; pfam00931 56107008720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107008721 binding surface 56107008722 TPR motif; other site 56107008723 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107008724 TPR repeat; Region: TPR_11; pfam13414 56107008725 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107008726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107008727 binding surface 56107008728 TPR motif; other site 56107008729 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107008730 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 56107008731 AMIN domain; Region: AMIN; pfam11741 56107008732 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 56107008733 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 56107008734 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 56107008735 Ligand Binding Site [chemical binding]; other site 56107008736 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 56107008737 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 56107008738 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 56107008739 active site 56107008740 catalytic triad [active] 56107008741 oxyanion hole [active] 56107008742 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352 56107008743 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 56107008744 active site 56107008745 catalytic site [active] 56107008746 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 56107008747 phosphopeptide binding site; other site 56107008748 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 56107008749 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 56107008750 phosphopeptide binding site; other site 56107008751 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 56107008752 Active_site [active] 56107008753 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 56107008754 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 56107008755 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 56107008756 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 56107008757 cofactor binding site; other site 56107008758 DNA binding site [nucleotide binding] 56107008759 substrate interaction site [chemical binding]; other site 56107008760 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 56107008761 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 56107008762 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 56107008763 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 56107008764 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 56107008765 active site 56107008766 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 56107008767 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 56107008768 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 56107008769 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 56107008770 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 56107008771 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 56107008772 Surface antigen; Region: Bac_surface_Ag; pfam01103 56107008773 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 56107008774 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 56107008775 ATP binding site [chemical binding]; other site 56107008776 active site 56107008777 substrate binding site [chemical binding]; other site 56107008778 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107008779 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 56107008780 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 56107008781 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 56107008782 NAD binding site [chemical binding]; other site 56107008783 substrate binding site [chemical binding]; other site 56107008784 active site 56107008785 Ycf46; Provisional; Region: ycf46; CHL00195 56107008786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107008787 Walker A motif; other site 56107008788 ATP binding site [chemical binding]; other site 56107008789 Walker B motif; other site 56107008790 arginine finger; other site 56107008791 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 56107008792 Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303 56107008793 inhibitor binding site; inhibition site 56107008794 catalytic motif [active] 56107008795 Catalytic residue [active] 56107008796 Active site flap [active] 56107008797 Uncharacterized conserved protein [Function unknown]; Region: COG1479 56107008798 Protein of unknown function DUF262; Region: DUF262; pfam03235 56107008799 2TM domain; Region: 2TM; pfam13239 56107008800 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 56107008801 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 56107008802 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 56107008803 homoserine kinase; Provisional; Region: PRK01212 56107008804 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 56107008805 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 56107008806 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 56107008807 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 56107008808 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 56107008809 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 56107008810 active site 56107008811 dimer interface [polypeptide binding]; other site 56107008812 motif 1; other site 56107008813 motif 2; other site 56107008814 motif 3; other site 56107008815 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 56107008816 anticodon binding site; other site 56107008817 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 56107008818 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 56107008819 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 56107008820 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 56107008821 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 56107008822 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107008823 GAF domain; Region: GAF; pfam01590 56107008824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107008825 dimer interface [polypeptide binding]; other site 56107008826 phosphorylation site [posttranslational modification] 56107008827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107008828 ATP binding site [chemical binding]; other site 56107008829 Mg2+ binding site [ion binding]; other site 56107008830 G-X-G motif; other site 56107008831 PsaD; Region: PsaD; pfam02531 56107008832 anthranilate synthase component I; Provisional; Region: PRK13565 56107008833 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 56107008834 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 56107008835 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107008836 putative active site [active] 56107008837 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 56107008838 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 56107008839 putative active site [active] 56107008840 catalytic triad [active] 56107008841 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 56107008842 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 56107008843 metal binding site 2 [ion binding]; metal-binding site 56107008844 putative DNA binding helix; other site 56107008845 metal binding site 1 [ion binding]; metal-binding site 56107008846 dimer interface [polypeptide binding]; other site 56107008847 structural Zn2+ binding site [ion binding]; other site 56107008848 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 56107008849 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 56107008850 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 56107008851 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 56107008852 active site 56107008853 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 56107008854 Uncharacterized conserved protein [Function unknown]; Region: COG1434 56107008855 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 56107008856 putative active site [active] 56107008857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 56107008858 Predicted kinase [General function prediction only]; Region: COG0645 56107008859 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 56107008860 ATP-binding site [chemical binding]; other site 56107008861 Gluconate-6-phosphate binding site [chemical binding]; other site 56107008862 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 56107008863 5S rRNA interface [nucleotide binding]; other site 56107008864 CTC domain interface [polypeptide binding]; other site 56107008865 L16 interface [polypeptide binding]; other site 56107008866 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 56107008867 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 56107008868 GDP-binding site [chemical binding]; other site 56107008869 ACT binding site; other site 56107008870 IMP binding site; other site 56107008871 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 56107008872 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 56107008873 active site 56107008874 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 56107008875 active site residue [active] 56107008876 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 56107008877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107008878 ATP binding site [chemical binding]; other site 56107008879 Mg2+ binding site [ion binding]; other site 56107008880 G-X-G motif; other site 56107008881 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 56107008882 ATP binding site [chemical binding]; other site 56107008883 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 56107008884 Yip1 domain; Region: Yip1; pfam04893 56107008885 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 56107008886 Double zinc ribbon; Region: DZR; pfam12773 56107008887 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 56107008888 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 56107008889 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 56107008890 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 56107008891 phytoene desaturase; Region: phytoene_desat; TIGR02731 56107008892 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107008893 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 56107008894 active site lid residues [active] 56107008895 substrate binding pocket [chemical binding]; other site 56107008896 catalytic residues [active] 56107008897 substrate-Mg2+ binding site; other site 56107008898 aspartate-rich region 1; other site 56107008899 aspartate-rich region 2; other site 56107008900 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 56107008901 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 56107008902 putative ligand binding site [chemical binding]; other site 56107008903 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 56107008904 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 56107008905 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 56107008906 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 56107008907 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 56107008908 dimer interface [polypeptide binding]; other site 56107008909 [2Fe-2S] cluster binding site [ion binding]; other site 56107008910 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 56107008911 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 56107008912 dimer interface [polypeptide binding]; other site 56107008913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107008914 catalytic residue [active] 56107008915 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 56107008916 Dynamin family; Region: Dynamin_N; pfam00350 56107008917 G1 box; other site 56107008918 GTP/Mg2+ binding site [chemical binding]; other site 56107008919 G2 box; other site 56107008920 Switch I region; other site 56107008921 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 56107008922 G3 box; other site 56107008923 Switch II region; other site 56107008924 GTP/Mg2+ binding site [chemical binding]; other site 56107008925 G4 box; other site 56107008926 G5 box; other site 56107008927 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 56107008928 Dynamin family; Region: Dynamin_N; pfam00350 56107008929 G1 box; other site 56107008930 GTP/Mg2+ binding site [chemical binding]; other site 56107008931 G2 box; other site 56107008932 Switch I region; other site 56107008933 G3 box; other site 56107008934 Switch II region; other site 56107008935 G4 box; other site 56107008936 G5 box; other site 56107008937 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107008938 HSP70 interaction site [polypeptide binding]; other site 56107008939 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 56107008940 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 56107008941 dimer interface [polypeptide binding]; other site 56107008942 decamer (pentamer of dimers) interface [polypeptide binding]; other site 56107008943 catalytic triad [active] 56107008944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107008945 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 56107008946 putative ADP-binding pocket [chemical binding]; other site 56107008947 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 56107008948 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107008949 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107008950 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 56107008951 active site 56107008952 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 56107008953 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 56107008954 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 56107008955 active site 56107008956 substrate binding site [chemical binding]; other site 56107008957 metal binding site [ion binding]; metal-binding site 56107008958 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 56107008959 heme binding pocket [chemical binding]; other site 56107008960 heme ligand [chemical binding]; other site 56107008961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107008962 AAA domain; Region: AAA_21; pfam13304 56107008963 Walker A/P-loop; other site 56107008964 ATP binding site [chemical binding]; other site 56107008965 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 56107008966 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 56107008967 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 56107008968 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 56107008969 classical (c) SDRs; Region: SDR_c; cd05233 56107008970 NAD(P) binding site [chemical binding]; other site 56107008971 active site 56107008972 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 56107008973 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 56107008974 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 56107008975 trimer interface [polypeptide binding]; other site 56107008976 dimer interface [polypeptide binding]; other site 56107008977 putative active site [active] 56107008978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107008979 Major Facilitator Superfamily; Region: MFS_1; pfam07690 56107008980 putative substrate translocation pore; other site 56107008981 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 56107008982 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 56107008983 Putative Catalytic site; other site 56107008984 DXD motif; other site 56107008985 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 56107008986 NlpC/P60 family; Region: NLPC_P60; pfam00877 56107008987 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 56107008988 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107008989 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 56107008990 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 56107008991 AAA domain; Region: AAA_21; pfam13304 56107008992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107008993 Walker B; other site 56107008994 D-loop; other site 56107008995 H-loop/switch region; other site 56107008996 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107008997 putative active site [active] 56107008998 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107008999 putative active site [active] 56107009000 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 56107009001 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 56107009002 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 56107009003 Uncharacterized conserved protein [Function unknown]; Region: COG3339 56107009004 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 56107009005 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 56107009006 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 56107009007 Predicted membrane protein [Function unknown]; Region: COG1950 56107009008 Thf1-like protein; Reviewed; Region: PRK13266 56107009009 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 56107009010 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 56107009011 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 56107009012 anti sigma factor interaction site; other site 56107009013 regulatory phosphorylation site [posttranslational modification]; other site 56107009014 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 56107009015 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 56107009016 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 56107009017 hydrophobic ligand binding site; other site 56107009018 Domain of unknown function DUF59; Region: DUF59; pfam01883 56107009019 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 56107009020 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 56107009021 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 56107009022 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 56107009023 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 56107009024 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 56107009025 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 56107009026 Ligand Binding Site [chemical binding]; other site 56107009027 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 56107009028 Ligand Binding Site [chemical binding]; other site 56107009029 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 56107009030 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 56107009031 NAD binding site [chemical binding]; other site 56107009032 putative substrate binding site 2 [chemical binding]; other site 56107009033 putative substrate binding site 1 [chemical binding]; other site 56107009034 active site 56107009035 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 56107009036 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 56107009037 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 56107009038 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 56107009039 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 56107009040 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 56107009041 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 56107009042 competence damage-inducible protein A; Provisional; Region: PRK00549 56107009043 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 56107009044 putative MPT binding site; other site 56107009045 Competence-damaged protein; Region: CinA; pfam02464 56107009046 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 56107009047 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 56107009048 Mg++ binding site [ion binding]; other site 56107009049 putative catalytic motif [active] 56107009050 substrate binding site [chemical binding]; other site 56107009051 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 56107009052 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 56107009053 dimer interface [polypeptide binding]; other site 56107009054 active site 56107009055 glycine-pyridoxal phosphate binding site [chemical binding]; other site 56107009056 folate binding site [chemical binding]; other site 56107009057 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 56107009058 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 56107009059 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 56107009060 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 56107009061 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 56107009062 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 56107009063 anti sigma factor interaction site; other site 56107009064 regulatory phosphorylation site [posttranslational modification]; other site 56107009065 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 56107009066 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 56107009067 argininosuccinate synthase; Provisional; Region: PRK13820 56107009068 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 56107009069 ANP binding site [chemical binding]; other site 56107009070 Substrate Binding Site II [chemical binding]; other site 56107009071 Substrate Binding Site I [chemical binding]; other site 56107009072 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107009073 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 56107009074 Probable Catalytic site; other site 56107009075 metal-binding site 56107009076 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 56107009077 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 56107009078 rRNA interaction site [nucleotide binding]; other site 56107009079 S8 interaction site; other site 56107009080 putative laminin-1 binding site; other site 56107009081 elongation factor Ts; Provisional; Region: tsf; PRK09377 56107009082 UBA/TS-N domain; Region: UBA; pfam00627 56107009083 Elongation factor TS; Region: EF_TS; pfam00889 56107009084 Elongation factor TS; Region: EF_TS; pfam00889 56107009085 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 56107009086 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 56107009087 generic binding surface II; other site 56107009088 ssDNA binding site; other site 56107009089 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107009090 ATP binding site [chemical binding]; other site 56107009091 putative Mg++ binding site [ion binding]; other site 56107009092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107009093 nucleotide binding region [chemical binding]; other site 56107009094 ATP-binding site [chemical binding]; other site 56107009095 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 56107009096 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107009097 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 56107009098 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 56107009099 Ferritin-like domain; Region: Ferritin; pfam00210 56107009100 dimanganese center [ion binding]; other site 56107009101 Predicted membrane protein [Function unknown]; Region: COG2261 56107009102 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 56107009103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107009104 FeS/SAM binding site; other site 56107009105 HemN C-terminal domain; Region: HemN_C; pfam06969 56107009106 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 56107009107 heme binding pocket [chemical binding]; other site 56107009108 heme ligand [chemical binding]; other site 56107009109 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 56107009110 diiron binding motif [ion binding]; other site 56107009111 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 56107009112 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107009113 substrate binding pocket [chemical binding]; other site 56107009114 membrane-bound complex binding site; other site 56107009115 hinge residues; other site 56107009116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107009117 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 56107009118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107009119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107009120 dimer interface [polypeptide binding]; other site 56107009121 phosphorylation site [posttranslational modification] 56107009122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107009123 ATP binding site [chemical binding]; other site 56107009124 Mg2+ binding site [ion binding]; other site 56107009125 G-X-G motif; other site 56107009126 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 56107009127 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 56107009128 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 56107009129 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 56107009130 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 56107009131 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 56107009132 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 56107009133 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107009134 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009135 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009136 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009137 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107009138 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009139 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107009141 TPR motif; other site 56107009142 binding surface 56107009143 TPR repeat; Region: TPR_11; pfam13414 56107009144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107009145 binding surface 56107009146 TPR motif; other site 56107009147 TPR repeat; Region: TPR_11; pfam13414 56107009148 TPR repeat; Region: TPR_11; pfam13414 56107009149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107009150 binding surface 56107009151 TPR motif; other site 56107009152 Tetratricopeptide repeat; Region: TPR_16; pfam13432 56107009153 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 56107009154 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 56107009155 Active Sites [active] 56107009156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107009157 dimerization interface [polypeptide binding]; other site 56107009158 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107009159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107009160 active site 56107009161 phosphorylation site [posttranslational modification] 56107009162 intermolecular recognition site; other site 56107009163 dimerization interface [polypeptide binding]; other site 56107009164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107009165 DNA binding site [nucleotide binding] 56107009166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107009167 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107009168 dimerization interface [polypeptide binding]; other site 56107009169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107009170 dimer interface [polypeptide binding]; other site 56107009171 phosphorylation site [posttranslational modification] 56107009172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107009173 ATP binding site [chemical binding]; other site 56107009174 Mg2+ binding site [ion binding]; other site 56107009175 G-X-G motif; other site 56107009176 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 56107009177 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 56107009178 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 56107009179 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 56107009180 putative ADP-binding pocket [chemical binding]; other site 56107009181 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107009182 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107009183 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 56107009184 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107009185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107009186 Walker A/P-loop; other site 56107009187 ATP binding site [chemical binding]; other site 56107009188 Q-loop/lid; other site 56107009189 ABC transporter signature motif; other site 56107009190 Walker B; other site 56107009191 D-loop; other site 56107009192 H-loop/switch region; other site 56107009193 Phosphotransferase enzyme family; Region: APH; pfam01636 56107009194 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 56107009195 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 56107009196 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 56107009197 active site 56107009198 metal binding site [ion binding]; metal-binding site 56107009199 DNA binding site [nucleotide binding] 56107009200 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 56107009201 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 56107009202 PBP superfamily domain; Region: PBP_like_2; cl17296 56107009203 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 56107009204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107009205 dimer interface [polypeptide binding]; other site 56107009206 conserved gate region; other site 56107009207 ABC-ATPase subunit interface; other site 56107009208 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 56107009209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107009210 dimer interface [polypeptide binding]; other site 56107009211 conserved gate region; other site 56107009212 putative PBP binding loops; other site 56107009213 ABC-ATPase subunit interface; other site 56107009214 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14265 56107009215 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 56107009216 Walker A/P-loop; other site 56107009217 ATP binding site [chemical binding]; other site 56107009218 Q-loop/lid; other site 56107009219 ABC transporter signature motif; other site 56107009220 Walker B; other site 56107009221 D-loop; other site 56107009222 H-loop/switch region; other site 56107009223 CheB methylesterase; Region: CheB_methylest; pfam01339 56107009224 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 56107009225 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 56107009226 DHH family; Region: DHH; pfam01368 56107009227 Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139 56107009228 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 56107009229 TniQ; Region: TniQ; pfam06527 56107009230 AAA domain; Region: AAA_22; pfam13401 56107009231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 56107009232 Walker A motif; other site 56107009233 ATP binding site [chemical binding]; other site 56107009234 Walker B motif; other site 56107009235 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 56107009236 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 56107009237 Integrase core domain; Region: rve; pfam00665 56107009238 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 56107009239 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 56107009240 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 56107009241 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 56107009242 active site 56107009243 zinc binding site [ion binding]; other site 56107009244 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 56107009245 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 56107009246 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 56107009247 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 56107009248 phosphopeptide binding site; other site 56107009249 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 56107009250 metal ion-dependent adhesion site (MIDAS); other site 56107009251 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 56107009252 Double zinc ribbon; Region: DZR; pfam12773 56107009253 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 56107009254 Protein phosphatase 2C; Region: PP2C; pfam00481 56107009255 active site 56107009256 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 56107009257 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107009258 active site 56107009259 ATP binding site [chemical binding]; other site 56107009260 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 56107009261 substrate binding site [chemical binding]; other site 56107009262 activation loop (A-loop); other site 56107009263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107009264 binding surface 56107009265 Tetratricopeptide repeat; Region: TPR_16; pfam13432 56107009266 TPR motif; other site 56107009267 Tetratricopeptide repeat; Region: TPR_16; pfam13432 56107009268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107009269 binding surface 56107009270 TPR motif; other site 56107009271 Double zinc ribbon; Region: DZR; pfam12773 56107009272 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 56107009273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 56107009274 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 56107009275 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 56107009276 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 56107009277 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 56107009278 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 56107009279 active site 56107009280 SAM binding site [chemical binding]; other site 56107009281 homodimer interface [polypeptide binding]; other site 56107009282 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 56107009283 active site 56107009284 SAM binding site [chemical binding]; other site 56107009285 homodimer interface [polypeptide binding]; other site 56107009286 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 56107009287 Precorrin-8X methylmutase; Region: CbiC; pfam02570 56107009288 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 56107009289 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 56107009290 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 56107009291 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107009292 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 56107009293 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 56107009294 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 56107009295 active site 56107009296 putative homodimer interface [polypeptide binding]; other site 56107009297 SAM binding site [chemical binding]; other site 56107009298 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 56107009299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107009300 S-adenosylmethionine binding site [chemical binding]; other site 56107009301 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 56107009302 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107009303 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 56107009304 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 56107009305 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107009306 active site 56107009307 catalytic residues [active] 56107009308 DNA binding site [nucleotide binding] 56107009309 Int/Topo IB signature motif; other site 56107009310 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 56107009311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107009312 NAD(P) binding site [chemical binding]; other site 56107009313 active site 56107009314 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 56107009315 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 56107009316 RNA binding surface [nucleotide binding]; other site 56107009317 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 56107009318 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 56107009319 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 56107009320 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 56107009321 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 56107009322 Walker A motif; other site 56107009323 ATP binding site [chemical binding]; other site 56107009324 Walker B motif; other site 56107009325 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 56107009326 ATP binding site [chemical binding]; other site 56107009327 Walker B motif; other site 56107009328 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 56107009329 tetramer interface [polypeptide binding]; other site 56107009330 dimer interface [polypeptide binding]; other site 56107009331 KaiA domain; Region: KaiA; pfam07688 56107009332 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 56107009333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107009334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107009335 dimer interface [polypeptide binding]; other site 56107009336 phosphorylation site [posttranslational modification] 56107009337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107009338 ATP binding site [chemical binding]; other site 56107009339 Mg2+ binding site [ion binding]; other site 56107009340 G-X-G motif; other site 56107009341 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107009342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107009343 active site 56107009344 phosphorylation site [posttranslational modification] 56107009345 intermolecular recognition site; other site 56107009346 dimerization interface [polypeptide binding]; other site 56107009347 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 56107009348 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 56107009349 Protein of unknown function (DUF565); Region: DUF565; pfam04483 56107009350 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 56107009351 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 56107009352 GAF domain; Region: GAF; pfam01590 56107009353 Phytochrome region; Region: PHY; pfam00360 56107009354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107009355 dimer interface [polypeptide binding]; other site 56107009356 phosphorylation site [posttranslational modification] 56107009357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107009358 ATP binding site [chemical binding]; other site 56107009359 Mg2+ binding site [ion binding]; other site 56107009360 G-X-G motif; other site 56107009361 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107009362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107009363 active site 56107009364 phosphorylation site [posttranslational modification] 56107009365 intermolecular recognition site; other site 56107009366 dimerization interface [polypeptide binding]; other site 56107009367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107009368 Response regulator receiver domain; Region: Response_reg; pfam00072 56107009369 active site 56107009370 phosphorylation site [posttranslational modification] 56107009371 intermolecular recognition site; other site 56107009372 dimerization interface [polypeptide binding]; other site 56107009373 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 56107009374 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 56107009375 metal binding site [ion binding]; metal-binding site 56107009376 active site 56107009377 I-site; other site 56107009378 hypothetical protein; Validated; Region: PRK00029 56107009379 Uncharacterized conserved protein [Function unknown]; Region: COG0397 56107009380 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 56107009381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 56107009382 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107009383 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 56107009384 biotin synthase; Region: bioB; TIGR00433 56107009385 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107009386 FeS/SAM binding site; other site 56107009387 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 56107009388 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 56107009389 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 56107009390 active site 56107009391 dimer interface [polypeptide binding]; other site 56107009392 metal binding site [ion binding]; metal-binding site 56107009393 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 56107009394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 56107009395 DNA-binding site [nucleotide binding]; DNA binding site 56107009396 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 56107009397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107009398 homodimer interface [polypeptide binding]; other site 56107009399 catalytic residue [active] 56107009400 Predicted metal-binding protein [Function unknown]; Region: COG5469 56107009401 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 56107009402 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 56107009403 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 56107009404 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 56107009405 active site 56107009406 metal binding site [ion binding]; metal-binding site 56107009407 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 56107009408 active site 56107009409 dinuclear metal binding site [ion binding]; other site 56107009410 dimerization interface [polypeptide binding]; other site 56107009411 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 56107009412 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 56107009413 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 56107009414 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 56107009415 putative NAD(P) binding site [chemical binding]; other site 56107009416 putative substrate binding site [chemical binding]; other site 56107009417 catalytic Zn binding site [ion binding]; other site 56107009418 structural Zn binding site [ion binding]; other site 56107009419 acylphosphatase; Provisional; Region: PRK14423 56107009420 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 56107009421 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 56107009422 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 56107009423 glycogen binding site [chemical binding]; other site 56107009424 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 56107009425 active site 56107009426 catalytic site [active] 56107009427 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 56107009428 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 56107009429 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 56107009430 cyanophycin synthetase; Provisional; Region: PRK14016 56107009431 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 56107009432 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 56107009433 proposed catalytic triad [active] 56107009434 active site nucleophile [active] 56107009435 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 56107009436 16S/18S rRNA binding site [nucleotide binding]; other site 56107009437 S13e-L30e interaction site [polypeptide binding]; other site 56107009438 25S rRNA binding site [nucleotide binding]; other site 56107009439 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 56107009440 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 56107009441 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 56107009442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107009443 Probable transposase; Region: OrfB_IS605; pfam01385 56107009444 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107009445 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 56107009446 arogenate dehydrogenase; Reviewed; Region: PRK07417 56107009447 prephenate dehydrogenase; Validated; Region: PRK08507 56107009448 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 56107009449 propionate/acetate kinase; Provisional; Region: PRK12379 56107009450 PAS domain S-box; Region: sensory_box; TIGR00229 56107009451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107009452 putative active site [active] 56107009453 heme pocket [chemical binding]; other site 56107009454 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107009455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107009456 putative active site [active] 56107009457 heme pocket [chemical binding]; other site 56107009458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107009459 putative active site [active] 56107009460 heme pocket [chemical binding]; other site 56107009461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107009462 PAS fold; Region: PAS_3; pfam08447 56107009463 putative active site [active] 56107009464 heme pocket [chemical binding]; other site 56107009465 PAS domain; Region: PAS_9; pfam13426 56107009466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107009467 PAS fold; Region: PAS_3; pfam08447 56107009468 putative active site [active] 56107009469 heme pocket [chemical binding]; other site 56107009470 PAS domain S-box; Region: sensory_box; TIGR00229 56107009471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107009472 putative active site [active] 56107009473 heme pocket [chemical binding]; other site 56107009474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107009475 PAS domain; Region: PAS_9; pfam13426 56107009476 putative active site [active] 56107009477 heme pocket [chemical binding]; other site 56107009478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 56107009479 Histidine kinase; Region: HisKA_2; pfam07568 56107009480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107009481 ATP binding site [chemical binding]; other site 56107009482 Mg2+ binding site [ion binding]; other site 56107009483 G-X-G motif; other site 56107009484 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107009485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107009486 active site 56107009487 phosphorylation site [posttranslational modification] 56107009488 intermolecular recognition site; other site 56107009489 dimerization interface [polypeptide binding]; other site 56107009490 PAS fold; Region: PAS; pfam00989 56107009491 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107009492 putative active site [active] 56107009493 heme pocket [chemical binding]; other site 56107009494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 56107009495 TPR motif; other site 56107009496 binding surface 56107009497 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 56107009498 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 56107009499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107009500 catalytic residue [active] 56107009501 FtsH Extracellular; Region: FtsH_ext; pfam06480 56107009502 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 56107009503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107009504 Walker A motif; other site 56107009505 ATP binding site [chemical binding]; other site 56107009506 Walker B motif; other site 56107009507 arginine finger; other site 56107009508 Peptidase family M41; Region: Peptidase_M41; pfam01434 56107009509 Uncharacterized conserved protein [Function unknown]; Region: COG1432 56107009510 LabA_like proteins; Region: LabA; cd10911 56107009511 putative metal binding site [ion binding]; other site 56107009512 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 56107009513 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 56107009514 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 56107009515 protein binding site [polypeptide binding]; other site 56107009516 transaldolase-like protein; Provisional; Region: PTZ00411 56107009517 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 56107009518 active site 56107009519 dimer interface [polypeptide binding]; other site 56107009520 catalytic residue [active] 56107009521 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 56107009522 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 56107009523 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 56107009524 putative phosphoketolase; Provisional; Region: PRK05261 56107009525 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 56107009526 TPP-binding site; other site 56107009527 XFP C-terminal domain; Region: XFP_C; pfam09363 56107009528 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 56107009529 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 56107009530 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 56107009531 RimM N-terminal domain; Region: RimM; pfam01782 56107009532 PRC-barrel domain; Region: PRC; pfam05239 56107009533 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 56107009534 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 56107009535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107009536 homodimer interface [polypeptide binding]; other site 56107009537 catalytic residue [active] 56107009538 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 56107009539 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 56107009540 substrate binding site [chemical binding]; other site 56107009541 catalytic Zn binding site [ion binding]; other site 56107009542 NAD binding site [chemical binding]; other site 56107009543 structural Zn binding site [ion binding]; other site 56107009544 dimer interface [polypeptide binding]; other site 56107009545 S-formylglutathione hydrolase; Region: PLN02442 56107009546 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 56107009547 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 56107009548 PemK-like protein; Region: PemK; pfam02452 56107009549 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 56107009550 cofactor binding site; other site 56107009551 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 56107009552 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 56107009553 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 56107009554 active site 56107009555 metal binding site [ion binding]; metal-binding site 56107009556 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 56107009557 Peptidase family M48; Region: Peptidase_M48; pfam01435 56107009558 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 56107009559 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 56107009560 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 56107009561 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 56107009562 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107009563 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 56107009564 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107009565 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107009566 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 56107009567 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 56107009568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107009569 Walker A/P-loop; other site 56107009570 ATP binding site [chemical binding]; other site 56107009571 Q-loop/lid; other site 56107009572 ABC transporter signature motif; other site 56107009573 Walker B; other site 56107009574 D-loop; other site 56107009575 H-loop/switch region; other site 56107009576 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 56107009577 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 56107009578 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107009579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107009580 active site 56107009581 phosphorylation site [posttranslational modification] 56107009582 intermolecular recognition site; other site 56107009583 dimerization interface [polypeptide binding]; other site 56107009584 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107009585 DNA binding residues [nucleotide binding] 56107009586 dimerization interface [polypeptide binding]; other site 56107009587 Response regulator receiver domain; Region: Response_reg; pfam00072 56107009588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107009589 active site 56107009590 phosphorylation site [posttranslational modification] 56107009591 intermolecular recognition site; other site 56107009592 dimerization interface [polypeptide binding]; other site 56107009593 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107009594 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107009595 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 56107009596 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 56107009597 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 56107009598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107009599 ATP binding site [chemical binding]; other site 56107009600 Mg2+ binding site [ion binding]; other site 56107009601 G-X-G motif; other site 56107009602 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 56107009603 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 56107009604 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 56107009605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107009606 motif II; other site 56107009607 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 56107009608 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 56107009609 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 56107009610 Walker A/P-loop; other site 56107009611 ATP binding site [chemical binding]; other site 56107009612 Q-loop/lid; other site 56107009613 ABC transporter signature motif; other site 56107009614 Walker B; other site 56107009615 D-loop; other site 56107009616 H-loop/switch region; other site 56107009617 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 56107009618 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 56107009619 FtsX-like permease family; Region: FtsX; pfam02687 56107009620 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 56107009621 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 56107009622 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107009623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 56107009624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 56107009625 Outer membrane efflux protein; Region: OEP; pfam02321 56107009626 Outer membrane efflux protein; Region: OEP; pfam02321 56107009627 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 56107009628 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 56107009629 Walker A/P-loop; other site 56107009630 ATP binding site [chemical binding]; other site 56107009631 Q-loop/lid; other site 56107009632 ABC transporter signature motif; other site 56107009633 Walker B; other site 56107009634 D-loop; other site 56107009635 H-loop/switch region; other site 56107009636 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 56107009637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 56107009638 active site 56107009639 phosphorylation site [posttranslational modification] 56107009640 intermolecular recognition site; other site 56107009641 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 56107009642 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 56107009643 FtsX-like permease family; Region: FtsX; pfam02687 56107009644 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 56107009645 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 56107009646 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107009647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107009648 binding surface 56107009649 TPR motif; other site 56107009650 TPR repeat; Region: TPR_11; pfam13414 56107009651 TPR repeat; Region: TPR_11; pfam13414 56107009652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107009653 binding surface 56107009654 TPR motif; other site 56107009655 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107009656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107009657 active site 56107009658 phosphorylation site [posttranslational modification] 56107009659 intermolecular recognition site; other site 56107009660 dimerization interface [polypeptide binding]; other site 56107009661 DNA gyrase subunit A; Validated; Region: PRK05560 56107009662 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 56107009663 CAP-like domain; other site 56107009664 active site 56107009665 primary dimer interface [polypeptide binding]; other site 56107009666 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 56107009667 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 56107009668 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 56107009669 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 56107009670 Protein of unkown function (DUF1881); Region: DUF1881; pfam08964 56107009671 light-harvesting-like protein 3; Provisional; Region: PLN00014 56107009672 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 56107009673 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 56107009674 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 56107009675 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 56107009676 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 56107009677 DNA binding residues [nucleotide binding] 56107009678 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 56107009679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107009680 Mg2+ binding site [ion binding]; other site 56107009681 G-X-G motif; other site 56107009682 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 56107009683 anchoring element; other site 56107009684 dimer interface [polypeptide binding]; other site 56107009685 ATP binding site [chemical binding]; other site 56107009686 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 56107009687 active site 56107009688 putative metal-binding site [ion binding]; other site 56107009689 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 56107009690 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 56107009691 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 56107009692 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107009693 putative active site [active] 56107009694 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 56107009695 Part of AAA domain; Region: AAA_19; pfam13245 56107009696 Family description; Region: UvrD_C_2; pfam13538 56107009697 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 56107009698 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 56107009699 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 56107009700 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 56107009701 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 56107009702 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 56107009703 active site 56107009704 metal binding site [ion binding]; metal-binding site 56107009705 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 56107009706 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 56107009707 putative active site cavity [active] 56107009708 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107009709 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107009710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107009711 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107009712 dimer interface [polypeptide binding]; other site 56107009713 phosphorylation site [posttranslational modification] 56107009714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107009715 ATP binding site [chemical binding]; other site 56107009716 Mg2+ binding site [ion binding]; other site 56107009717 G-X-G motif; other site 56107009718 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 56107009719 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 56107009720 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 56107009721 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107009722 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 56107009723 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107009724 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107009725 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107009726 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 56107009727 metal binding site 2 [ion binding]; metal-binding site 56107009728 putative DNA binding helix; other site 56107009729 metal binding site 1 [ion binding]; metal-binding site 56107009730 dimer interface [polypeptide binding]; other site 56107009731 structural Zn2+ binding site [ion binding]; other site 56107009732 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 56107009733 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 56107009734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 56107009735 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 56107009736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 56107009737 DNA binding residues [nucleotide binding] 56107009738 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 56107009739 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 56107009740 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 56107009741 lipoyl synthase; Provisional; Region: PRK05481 56107009742 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107009743 FeS/SAM binding site; other site 56107009744 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 56107009745 Conserved protein implicated in secretion [Cell motility and secretion]; Region: VPS24; COG5491 56107009746 TPR repeat; Region: TPR_11; pfam13414 56107009747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107009748 binding surface 56107009749 TPR repeat; Region: TPR_11; pfam13414 56107009750 TPR motif; other site 56107009751 TPR repeat; Region: TPR_11; pfam13414 56107009752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107009753 binding surface 56107009754 TPR repeat; Region: TPR_11; pfam13414 56107009755 TPR motif; other site 56107009756 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 56107009757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107009758 binding surface 56107009759 TPR motif; other site 56107009760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107009761 binding surface 56107009762 TPR motif; other site 56107009763 Caspase domain; Region: Peptidase_C14; pfam00656 56107009764 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 56107009765 ATP-sulfurylase; Region: ATPS; cd00517 56107009766 active site 56107009767 HXXH motif; other site 56107009768 flexible loop; other site 56107009769 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 56107009770 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 56107009771 GAD domain; Region: GAD; pfam02938 56107009772 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 56107009773 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 56107009774 Uncharacterized conserved protein [Function unknown]; Region: COG0062 56107009775 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 56107009776 putative substrate binding site [chemical binding]; other site 56107009777 putative ATP binding site [chemical binding]; other site 56107009778 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 56107009779 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 56107009780 putative trimer interface [polypeptide binding]; other site 56107009781 putative CoA binding site [chemical binding]; other site 56107009782 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 56107009783 putative trimer interface [polypeptide binding]; other site 56107009784 putative CoA binding site [chemical binding]; other site 56107009785 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 56107009786 oligomeric interface; other site 56107009787 putative active site [active] 56107009788 homodimer interface [polypeptide binding]; other site 56107009789 PAS fold; Region: PAS_4; pfam08448 56107009790 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107009791 putative active site [active] 56107009792 heme pocket [chemical binding]; other site 56107009793 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107009794 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107009795 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107009796 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107009797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107009798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107009799 dimer interface [polypeptide binding]; other site 56107009800 phosphorylation site [posttranslational modification] 56107009801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107009802 ATP binding site [chemical binding]; other site 56107009803 Mg2+ binding site [ion binding]; other site 56107009804 G-X-G motif; other site 56107009805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 56107009806 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 56107009807 FAD binding domain; Region: FAD_binding_4; pfam01565 56107009808 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 56107009809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107009810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107009811 dimerization interface [polypeptide binding]; other site 56107009812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107009813 dimer interface [polypeptide binding]; other site 56107009814 phosphorylation site [posttranslational modification] 56107009815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107009816 ATP binding site [chemical binding]; other site 56107009817 Mg2+ binding site [ion binding]; other site 56107009818 G-X-G motif; other site 56107009819 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 56107009820 Chondroitin sulphate attachment domain; Region: Chon_Sulph_att; pfam06566 56107009821 S-layer homology domain; Region: SLH; pfam00395 56107009822 S-layer homology domain; Region: SLH; pfam00395 56107009823 S-layer homology domain; Region: SLH; pfam00395 56107009824 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 56107009825 homoserine dehydrogenase; Provisional; Region: PRK06349 56107009826 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 56107009827 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 56107009828 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 56107009829 ferredoxin--NADP(+) reductase; Provisional; Region: PLN03115 56107009830 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 56107009831 dimerization interface [polypeptide binding]; other site 56107009832 FAD binding pocket [chemical binding]; other site 56107009833 FAD binding motif [chemical binding]; other site 56107009834 catalytic residues [active] 56107009835 NAD binding pocket [chemical binding]; other site 56107009836 phosphate binding motif [ion binding]; other site 56107009837 beta-alpha-beta structure motif; other site 56107009838 phosphoribulokinase; Provisional; Region: PRK07429 56107009839 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 56107009840 active site 56107009841 S-adenosylmethionine synthetase; Validated; Region: PRK05250 56107009842 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 56107009843 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 56107009844 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 56107009845 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009846 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107009847 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009848 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 56107009849 PGAP1-like protein; Region: PGAP1; pfam07819 56107009850 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 56107009851 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107009852 putative active site [active] 56107009853 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 56107009854 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 56107009855 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 56107009856 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 56107009857 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 56107009858 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107009859 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107009860 active site 56107009861 ATP binding site [chemical binding]; other site 56107009862 substrate binding site [chemical binding]; other site 56107009863 activation loop (A-loop); other site 56107009864 hydrolase, alpha/beta fold family protein; Region: PLN02824 56107009865 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 56107009866 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 56107009867 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 56107009868 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 56107009869 S-layer homology domain; Region: SLH; pfam00395 56107009870 S-layer homology domain; Region: SLH; pfam00395 56107009871 Mechanosensitive ion channel; Region: MS_channel; pfam00924 56107009872 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 56107009873 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 56107009874 putative active site [active] 56107009875 Zn binding site [ion binding]; other site 56107009876 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 56107009877 AAA domain; Region: AAA_11; pfam13086 56107009878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107009879 Walker A motif; other site 56107009880 ATP binding site [chemical binding]; other site 56107009881 AAA domain; Region: AAA_11; pfam13086 56107009882 AAA domain; Region: AAA_12; pfam13087 56107009883 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 56107009884 PLD-like domain; Region: PLDc_2; pfam13091 56107009885 putative active site [active] 56107009886 putative catalytic site [active] 56107009887 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 56107009888 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 56107009889 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 56107009890 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 56107009891 Peptidase family M23; Region: Peptidase_M23; pfam01551 56107009892 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 56107009893 Dynamin family; Region: Dynamin_N; pfam00350 56107009894 G1 box; other site 56107009895 GTP/Mg2+ binding site [chemical binding]; other site 56107009896 G2 box; other site 56107009897 Switch I region; other site 56107009898 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 56107009899 G3 box; other site 56107009900 Switch II region; other site 56107009901 GTP/Mg2+ binding site [chemical binding]; other site 56107009902 G4 box; other site 56107009903 G5 box; other site 56107009904 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 56107009905 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 56107009906 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 56107009907 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 56107009908 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 56107009909 dimer interface [polypeptide binding]; other site 56107009910 decamer (pentamer of dimers) interface [polypeptide binding]; other site 56107009911 catalytic triad [active] 56107009912 peroxidatic and resolving cysteines [active] 56107009913 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 56107009914 putative catalytic residues [active] 56107009915 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 56107009916 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 56107009917 C-terminal domain interface [polypeptide binding]; other site 56107009918 GSH binding site (G-site) [chemical binding]; other site 56107009919 dimer interface [polypeptide binding]; other site 56107009920 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 56107009921 N-terminal domain interface [polypeptide binding]; other site 56107009922 dimer interface [polypeptide binding]; other site 56107009923 substrate binding pocket (H-site) [chemical binding]; other site 56107009924 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 56107009925 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107009926 HSP70 interaction site [polypeptide binding]; other site 56107009927 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 56107009928 substrate binding site [polypeptide binding]; other site 56107009929 dimer interface [polypeptide binding]; other site 56107009930 AAA domain; Region: AAA_33; pfam13671 56107009931 AAA domain; Region: AAA_17; pfam13207 56107009932 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 56107009933 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 56107009934 ligand binding site; other site 56107009935 oligomer interface; other site 56107009936 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 56107009937 dimer interface [polypeptide binding]; other site 56107009938 N-terminal domain interface [polypeptide binding]; other site 56107009939 sulfate 1 binding site; other site 56107009940 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 56107009941 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 56107009942 active site 56107009943 homodimer interface [polypeptide binding]; other site 56107009944 catalytic site [active] 56107009945 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107009946 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107009947 active site 56107009948 KGK domain; Region: KGK; pfam08872 56107009949 KGK domain; Region: KGK; pfam08872 56107009950 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 56107009951 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 56107009952 G1 box; other site 56107009953 GTP/Mg2+ binding site [chemical binding]; other site 56107009954 G2 box; other site 56107009955 Switch I region; other site 56107009956 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 56107009957 G3 box; other site 56107009958 Switch II region; other site 56107009959 GTP/Mg2+ binding site [chemical binding]; other site 56107009960 G4 box; other site 56107009961 G5 box; other site 56107009962 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 56107009963 Peptidase family U32; Region: Peptidase_U32; pfam01136 56107009964 Collagenase; Region: DUF3656; pfam12392 56107009965 Peptidase family U32; Region: Peptidase_U32; cl03113 56107009966 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 56107009967 Putative phosphatase (DUF442); Region: DUF442; cl17385 56107009968 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107009969 putative active site [active] 56107009970 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 56107009971 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 56107009972 active site 56107009973 catalytic tetrad [active] 56107009974 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 56107009975 Uncharacterized conserved protein [Function unknown]; Region: COG1259 56107009976 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 56107009977 Lumazine binding domain; Region: Lum_binding; pfam00677 56107009978 Lumazine binding domain; Region: Lum_binding; pfam00677 56107009979 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 56107009980 Peptidase family M23; Region: Peptidase_M23; pfam01551 56107009981 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 56107009982 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 56107009983 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 56107009984 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 56107009985 Methyltransferase domain; Region: Methyltransf_23; pfam13489 56107009986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107009987 S-adenosylmethionine binding site [chemical binding]; other site 56107009988 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107009989 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009990 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009991 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107009992 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009993 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009994 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009995 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107009996 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009997 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107009998 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 56107009999 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 56107010000 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 56107010001 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 56107010002 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 56107010003 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 56107010004 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 56107010005 catalytic residues [active] 56107010006 phosphodiesterase; Provisional; Region: PRK12704 56107010007 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 56107010008 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107010009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107010010 active site 56107010011 phosphorylation site [posttranslational modification] 56107010012 intermolecular recognition site; other site 56107010013 dimerization interface [polypeptide binding]; other site 56107010014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107010015 DNA binding site [nucleotide binding] 56107010016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107010017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107010018 dimer interface [polypeptide binding]; other site 56107010019 phosphorylation site [posttranslational modification] 56107010020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107010021 ATP binding site [chemical binding]; other site 56107010022 Mg2+ binding site [ion binding]; other site 56107010023 G-X-G motif; other site 56107010024 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 56107010025 PhoU domain; Region: PhoU; pfam01895 56107010026 PhoU domain; Region: PhoU; pfam01895 56107010027 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 56107010028 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 56107010029 ligand binding site [chemical binding]; other site 56107010030 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 56107010031 putative switch regulator; other site 56107010032 non-specific DNA interactions [nucleotide binding]; other site 56107010033 DNA binding site [nucleotide binding] 56107010034 sequence specific DNA binding site [nucleotide binding]; other site 56107010035 putative cAMP binding site [chemical binding]; other site 56107010036 S-layer homology domain; Region: SLH; pfam00395 56107010037 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 56107010038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107010039 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107010040 Probable transposase; Region: OrfB_IS605; pfam01385 56107010041 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107010042 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 56107010043 aspartate aminotransferase; Provisional; Region: PRK05957 56107010044 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 56107010045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107010046 homodimer interface [polypeptide binding]; other site 56107010047 catalytic residue [active] 56107010048 Uncharacterized conserved protein [Function unknown]; Region: COG0432 56107010049 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 56107010050 NADH(P)-binding; Region: NAD_binding_10; pfam13460 56107010051 NAD(P) binding site [chemical binding]; other site 56107010052 putative active site [active] 56107010053 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107010054 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107010055 structural tetrad; other site 56107010056 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 56107010057 ligand binding surface [chemical binding]; other site 56107010058 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 56107010059 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 56107010060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107010061 Walker A motif; other site 56107010062 ATP binding site [chemical binding]; other site 56107010063 Walker B motif; other site 56107010064 arginine finger; other site 56107010065 Peptidase family M41; Region: Peptidase_M41; pfam01434 56107010066 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 56107010067 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 56107010068 Domain of unknown function DUF20; Region: UPF0118; pfam01594 56107010069 Divergent AAA domain; Region: AAA_4; pfam04326 56107010070 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107010071 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 56107010072 Domain of unknown function DUF39; Region: DUF39; pfam01837 56107010073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 56107010074 TPR motif; other site 56107010075 binding surface 56107010076 TPR repeat; Region: TPR_11; pfam13414 56107010077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107010078 binding surface 56107010079 TPR motif; other site 56107010080 Predicted membrane protein [Function unknown]; Region: COG2119 56107010081 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 56107010082 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 56107010083 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 56107010084 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107010085 XisI protein; Region: XisI; pfam08869 56107010086 XisH protein; Region: XisH; pfam08814 56107010087 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 56107010088 L-aspartate oxidase; Provisional; Region: PRK06175 56107010089 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 56107010090 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 56107010091 S-layer homology domain; Region: SLH; pfam00395 56107010092 S-layer homology domain; Region: SLH; pfam00395 56107010093 S-layer homology domain; Region: SLH; pfam00395 56107010094 KWG Leptospira; Region: KWG; pfam07656 56107010095 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 56107010096 active site 56107010097 metal binding site [ion binding]; metal-binding site 56107010098 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 56107010099 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 56107010100 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 56107010101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107010102 S-adenosylmethionine binding site [chemical binding]; other site 56107010103 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 56107010104 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 56107010105 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107010106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107010107 active site 56107010108 phosphorylation site [posttranslational modification] 56107010109 intermolecular recognition site; other site 56107010110 dimerization interface [polypeptide binding]; other site 56107010111 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107010112 DNA binding residues [nucleotide binding] 56107010113 dimerization interface [polypeptide binding]; other site 56107010114 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 56107010115 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 56107010116 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 56107010117 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 56107010118 active site 56107010119 CHAT domain; Region: CHAT; pfam12770 56107010120 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 56107010121 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 56107010122 phosphopeptide binding site; other site 56107010123 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 56107010124 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 56107010125 phosphopeptide binding site; other site 56107010126 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 56107010127 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 56107010128 Predicted membrane protein [Function unknown]; Region: COG3431 56107010129 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 56107010130 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 56107010131 [4Fe-4S] binding site [ion binding]; other site 56107010132 molybdopterin cofactor binding site; other site 56107010133 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 56107010134 molybdopterin cofactor binding site; other site 56107010135 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 56107010136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107010137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107010138 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 56107010139 NMT1-like family; Region: NMT1_2; pfam13379 56107010140 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 56107010141 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 56107010142 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 56107010143 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 56107010144 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 56107010145 iron-sulfur cluster [ion binding]; other site 56107010146 [2Fe-2S] cluster binding site [ion binding]; other site 56107010147 HEAT repeats; Region: HEAT_2; pfam13646 56107010148 HEAT repeats; Region: HEAT_2; pfam13646 56107010149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107010150 binding surface 56107010151 TPR motif; other site 56107010152 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107010153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 56107010154 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 56107010155 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 56107010156 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 56107010157 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 56107010158 Surface antigen; Region: Bac_surface_Ag; pfam01103 56107010159 Transcriptional regulator [Transcription]; Region: LysR; COG0583 56107010160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 56107010161 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 56107010162 dimerization interface [polypeptide binding]; other site 56107010163 hypothetical protein; Provisional; Region: PRK07394 56107010164 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 56107010165 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 56107010166 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 56107010167 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 56107010168 tetramerization interface [polypeptide binding]; other site 56107010169 active site 56107010170 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 56107010171 dimer interface [polypeptide binding]; other site 56107010172 substrate binding site [chemical binding]; other site 56107010173 metal binding sites [ion binding]; metal-binding site 56107010174 Uncharacterized conserved protein [Function unknown]; Region: COG2006 56107010175 Domain of unknown function (DUF362); Region: DUF362; pfam04015 56107010176 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 56107010177 Aspartase; Region: Aspartase; cd01357 56107010178 active sites [active] 56107010179 tetramer interface [polypeptide binding]; other site 56107010180 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107010181 putative active site [active] 56107010182 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 56107010183 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 56107010184 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 56107010185 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 56107010186 putative NAD(P) binding site [chemical binding]; other site 56107010187 active site 56107010188 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 56107010189 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107010190 putative ADP-binding pocket [chemical binding]; other site 56107010191 Bacterial sugar transferase; Region: Bac_transf; pfam02397 56107010192 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 56107010193 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 56107010194 NADP-binding site; other site 56107010195 homotetramer interface [polypeptide binding]; other site 56107010196 substrate binding site [chemical binding]; other site 56107010197 homodimer interface [polypeptide binding]; other site 56107010198 active site 56107010199 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 56107010200 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 56107010201 NADP binding site [chemical binding]; other site 56107010202 active site 56107010203 putative substrate binding site [chemical binding]; other site 56107010204 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 56107010205 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 56107010206 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107010207 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 56107010208 Uncharacterized conserved protein [Function unknown]; Region: COG1434 56107010209 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 56107010210 putative active site [active] 56107010211 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 56107010212 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 56107010213 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 56107010214 protein binding site [polypeptide binding]; other site 56107010215 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 56107010216 Catalytic dyad [active] 56107010217 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107010218 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 56107010219 active site 56107010220 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 56107010221 putative dimer interface [polypeptide binding]; other site 56107010222 active site pocket [active] 56107010223 putative cataytic base [active] 56107010224 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 56107010225 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107010226 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107010227 ligand binding site [chemical binding]; other site 56107010228 flexible hinge region; other site 56107010229 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 56107010230 putative switch regulator; other site 56107010231 non-specific DNA interactions [nucleotide binding]; other site 56107010232 DNA binding site [nucleotide binding] 56107010233 sequence specific DNA binding site [nucleotide binding]; other site 56107010234 putative cAMP binding site [chemical binding]; other site 56107010235 universal archaeal protein Kae1; Region: arch_KAE1; TIGR03722 56107010236 Bacterial sugar transferase; Region: Bac_transf; pfam02397 56107010237 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 56107010238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107010239 dimer interface [polypeptide binding]; other site 56107010240 conserved gate region; other site 56107010241 putative PBP binding loops; other site 56107010242 ABC-ATPase subunit interface; other site 56107010243 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 56107010244 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 56107010245 DHH family; Region: DHH; pfam01368 56107010246 DHHA1 domain; Region: DHHA1; pfam02272 56107010247 KWG Leptospira; Region: KWG; pfam07656 56107010248 KWG Leptospira; Region: KWG; pfam07656 56107010249 KWG Leptospira; Region: KWG; pfam07656 56107010250 KWG Leptospira; Region: KWG; pfam07656 56107010251 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 56107010252 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 56107010253 active site 56107010254 catalytic residues [active] 56107010255 metal binding site [ion binding]; metal-binding site 56107010256 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 56107010257 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 56107010258 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 56107010259 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 56107010260 ribosomal protein S14; Region: rps14; CHL00074 56107010261 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 56107010262 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 56107010263 minor groove reading motif; other site 56107010264 helix-hairpin-helix signature motif; other site 56107010265 substrate binding pocket [chemical binding]; other site 56107010266 active site 56107010267 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 56107010268 RIP metalloprotease RseP; Region: TIGR00054 56107010269 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 56107010270 active site 56107010271 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 56107010272 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 56107010273 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 56107010274 putative active site [active] 56107010275 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 56107010276 active site 56107010277 nucleophile elbow; other site 56107010278 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 56107010279 seryl-tRNA synthetase; Provisional; Region: PRK05431 56107010280 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 56107010281 dimer interface [polypeptide binding]; other site 56107010282 active site 56107010283 motif 1; other site 56107010284 motif 2; other site 56107010285 motif 3; other site 56107010286 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 56107010287 Predicted transcriptional regulators [Transcription]; Region: COG1695 56107010288 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 56107010289 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 56107010290 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 56107010291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107010292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107010293 dimer interface [polypeptide binding]; other site 56107010294 phosphorylation site [posttranslational modification] 56107010295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107010296 ATP binding site [chemical binding]; other site 56107010297 Mg2+ binding site [ion binding]; other site 56107010298 G-X-G motif; other site 56107010299 S-layer homology domain; Region: SLH; pfam00395 56107010300 S-layer homology domain; Region: SLH; pfam00395 56107010301 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 56107010302 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 56107010303 Walker A/P-loop; other site 56107010304 ATP binding site [chemical binding]; other site 56107010305 Q-loop/lid; other site 56107010306 Rad50 zinc hook motif; Region: Rad50_zn_hook; pfam04423 56107010307 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 56107010308 ABC transporter signature motif; other site 56107010309 Walker B; other site 56107010310 D-loop; other site 56107010311 H-loop/switch region; other site 56107010312 PAS fold; Region: PAS_7; pfam12860 56107010313 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 56107010314 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 56107010315 metal binding site [ion binding]; metal-binding site 56107010316 active site 56107010317 I-site; other site 56107010318 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 56107010319 Bacterial SH3 domain; Region: SH3_3; cl17532 56107010320 Ycf46; Provisional; Region: ycf46; CHL00195 56107010321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107010322 Walker A motif; other site 56107010323 ATP binding site [chemical binding]; other site 56107010324 Walker B motif; other site 56107010325 arginine finger; other site 56107010326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107010327 Walker A/P-loop; other site 56107010328 ATP binding site [chemical binding]; other site 56107010329 AAA domain; Region: AAA_21; pfam13304 56107010330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 56107010331 Q-loop/lid; other site 56107010332 ABC transporter signature motif; other site 56107010333 Walker B; other site 56107010334 D-loop; other site 56107010335 H-loop/switch region; other site 56107010336 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 56107010337 oligomeric interface; other site 56107010338 putative active site [active] 56107010339 homodimer interface [polypeptide binding]; other site 56107010340 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 56107010341 putative active site [active] 56107010342 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 56107010343 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 56107010344 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 56107010345 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 56107010346 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 56107010347 G-X-X-G motif; other site 56107010348 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 56107010349 RxxxH motif; other site 56107010350 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 56107010351 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 56107010352 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 56107010353 Bacterial PH domain; Region: DUF304; pfam03703 56107010354 ribonuclease P; Reviewed; Region: rnpA; PRK03031 56107010355 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 56107010356 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 56107010357 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 56107010358 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 56107010359 ligand binding site [chemical binding]; other site 56107010360 homodimer interface [polypeptide binding]; other site 56107010361 NAD(P) binding site [chemical binding]; other site 56107010362 trimer interface B [polypeptide binding]; other site 56107010363 trimer interface A [polypeptide binding]; other site 56107010364 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 56107010365 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 56107010366 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 56107010367 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107010368 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 56107010369 XisI protein; Region: XisI; pfam08869 56107010370 XisH protein; Region: XisH; pfam08814 56107010371 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 56107010372 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 56107010373 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107010374 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107010375 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107010376 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107010377 GAF domain; Region: GAF; pfam01590 56107010378 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107010379 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107010380 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107010381 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107010382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107010383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107010384 ATP binding site [chemical binding]; other site 56107010385 Mg2+ binding site [ion binding]; other site 56107010386 G-X-G motif; other site 56107010387 PetN; Region: PetN; pfam03742 56107010388 EVE domain; Region: EVE; cl00728 56107010389 Transcriptional regulators [Transcription]; Region: MarR; COG1846 56107010390 MarR family; Region: MarR; pfam01047 56107010391 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 56107010392 active site 56107010393 catalytic site [active] 56107010394 substrate binding site [chemical binding]; other site 56107010395 Predicted membrane protein [Function unknown]; Region: COG5305 56107010396 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 56107010397 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 56107010398 Ligand binding site; other site 56107010399 Putative Catalytic site; other site 56107010400 DXD motif; other site 56107010401 Predicted membrane protein [Function unknown]; Region: COG2246 56107010402 GtrA-like protein; Region: GtrA; pfam04138 56107010403 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 56107010404 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 56107010405 FO synthase subunit 2; Reviewed; Region: PRK07360 56107010406 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107010407 FeS/SAM binding site; other site 56107010408 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 56107010409 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 56107010410 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 56107010411 DNA polymerase I; Provisional; Region: PRK05755 56107010412 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 56107010413 active site 56107010414 metal binding site 1 [ion binding]; metal-binding site 56107010415 putative 5' ssDNA interaction site; other site 56107010416 metal binding site 3; metal-binding site 56107010417 metal binding site 2 [ion binding]; metal-binding site 56107010418 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 56107010419 putative DNA binding site [nucleotide binding]; other site 56107010420 putative metal binding site [ion binding]; other site 56107010421 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 56107010422 active site 56107010423 catalytic site [active] 56107010424 substrate binding site [chemical binding]; other site 56107010425 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 56107010426 active site 56107010427 DNA binding site [nucleotide binding] 56107010428 catalytic site [active] 56107010429 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 56107010430 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107010431 DALR anticodon binding domain; Region: DALR_1; smart00836 56107010432 anticodon binding site; other site 56107010433 tRNA binding surface [nucleotide binding]; other site 56107010434 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107010435 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 56107010436 putative switch regulator; other site 56107010437 non-specific DNA interactions [nucleotide binding]; other site 56107010438 DNA binding site [nucleotide binding] 56107010439 sequence specific DNA binding site [nucleotide binding]; other site 56107010440 putative cAMP binding site [chemical binding]; other site 56107010441 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107010442 active site 56107010443 ATP binding site [chemical binding]; other site 56107010444 substrate binding site [chemical binding]; other site 56107010445 activation loop (A-loop); other site 56107010446 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 56107010447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 56107010448 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 56107010449 putative dimerization interface [polypeptide binding]; other site 56107010450 Predicted membrane protein [Function unknown]; Region: COG4094 56107010451 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 56107010452 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 56107010453 catalytic residues [active] 56107010454 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 56107010455 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 56107010456 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 56107010457 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 56107010458 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 56107010459 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 56107010460 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107010461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 56107010462 Uncharacterized conserved protein [Function unknown]; Region: COG2442 56107010463 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 56107010464 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107010465 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 56107010466 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 56107010467 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 56107010468 active site 56107010469 substrate binding site [chemical binding]; other site 56107010470 metal binding site [ion binding]; metal-binding site 56107010471 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 56107010472 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 56107010473 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 56107010474 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 56107010475 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 56107010476 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 56107010477 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 56107010478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107010479 motif II; other site 56107010480 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 56107010481 recombination protein F; Reviewed; Region: recF; PRK00064 56107010482 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 56107010483 Walker A/P-loop; other site 56107010484 ATP binding site [chemical binding]; other site 56107010485 Q-loop/lid; other site 56107010486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107010487 ABC transporter signature motif; other site 56107010488 Walker B; other site 56107010489 D-loop; other site 56107010490 H-loop/switch region; other site 56107010491 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 56107010492 MgtC family; Region: MgtC; pfam02308 56107010493 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 56107010494 DNA binding residues [nucleotide binding] 56107010495 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 56107010496 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 56107010497 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 56107010498 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 56107010499 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 56107010500 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 56107010501 PemK-like protein; Region: PemK; cl00995 56107010502 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 56107010503 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 56107010504 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 56107010505 catalytic residue [active] 56107010506 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 56107010507 Moco binding site; other site 56107010508 metal coordination site [ion binding]; other site 56107010509 dimerization interface [polypeptide binding]; other site 56107010510 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 56107010511 Predicted membrane protein [Function unknown]; Region: COG4330 56107010512 Response regulator receiver domain; Region: Response_reg; pfam00072 56107010513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107010514 active site 56107010515 phosphorylation site [posttranslational modification] 56107010516 intermolecular recognition site; other site 56107010517 dimerization interface [polypeptide binding]; other site 56107010518 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107010519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107010520 putative active site [active] 56107010521 heme pocket [chemical binding]; other site 56107010522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107010523 dimer interface [polypeptide binding]; other site 56107010524 phosphorylation site [posttranslational modification] 56107010525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107010526 ATP binding site [chemical binding]; other site 56107010527 Mg2+ binding site [ion binding]; other site 56107010528 G-X-G motif; other site 56107010529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107010530 Response regulator receiver domain; Region: Response_reg; pfam00072 56107010531 active site 56107010532 phosphorylation site [posttranslational modification] 56107010533 intermolecular recognition site; other site 56107010534 dimerization interface [polypeptide binding]; other site 56107010535 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 56107010536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107010537 dimerization interface [polypeptide binding]; other site 56107010538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107010539 dimerization interface [polypeptide binding]; other site 56107010540 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107010541 dimerization interface [polypeptide binding]; other site 56107010542 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 56107010543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107010544 dimerization interface [polypeptide binding]; other site 56107010545 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107010546 dimerization interface [polypeptide binding]; other site 56107010547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107010548 dimerization interface [polypeptide binding]; other site 56107010549 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 56107010550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107010551 dimerization interface [polypeptide binding]; other site 56107010552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107010553 dimerization interface [polypeptide binding]; other site 56107010554 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 56107010555 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107010556 dimerization interface [polypeptide binding]; other site 56107010557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107010558 dimerization interface [polypeptide binding]; other site 56107010559 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107010560 dimerization interface [polypeptide binding]; other site 56107010561 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107010562 dimerization interface [polypeptide binding]; other site 56107010563 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107010564 GAF domain; Region: GAF; pfam01590 56107010565 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 56107010566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107010567 ATP binding site [chemical binding]; other site 56107010568 Mg2+ binding site [ion binding]; other site 56107010569 G-X-G motif; other site 56107010570 Response regulator receiver domain; Region: Response_reg; pfam00072 56107010571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107010572 active site 56107010573 phosphorylation site [posttranslational modification] 56107010574 intermolecular recognition site; other site 56107010575 dimerization interface [polypeptide binding]; other site 56107010576 Response regulator receiver domain; Region: Response_reg; pfam00072 56107010577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107010578 active site 56107010579 phosphorylation site [posttranslational modification] 56107010580 intermolecular recognition site; other site 56107010581 dimerization interface [polypeptide binding]; other site 56107010582 Response regulator receiver domain; Region: Response_reg; pfam00072 56107010583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107010584 active site 56107010585 phosphorylation site [posttranslational modification] 56107010586 intermolecular recognition site; other site 56107010587 dimerization interface [polypeptide binding]; other site 56107010588 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 56107010589 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 56107010590 Walker A/P-loop; other site 56107010591 ATP binding site [chemical binding]; other site 56107010592 Q-loop/lid; other site 56107010593 ABC transporter signature motif; other site 56107010594 Walker B; other site 56107010595 D-loop; other site 56107010596 H-loop/switch region; other site 56107010597 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 56107010598 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 56107010599 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 56107010600 PDGLE domain; Region: PDGLE; pfam13190 56107010601 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 56107010602 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 56107010603 Walker A/P-loop; other site 56107010604 ATP binding site [chemical binding]; other site 56107010605 Q-loop/lid; other site 56107010606 ABC transporter signature motif; other site 56107010607 Walker B; other site 56107010608 D-loop; other site 56107010609 H-loop/switch region; other site 56107010610 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 56107010611 cobalt transport protein CbiN; Provisional; Region: PRK02898 56107010612 cobalt transport protein CbiM; Validated; Region: PRK08319 56107010613 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 56107010614 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 56107010615 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 56107010616 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 56107010617 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 56107010618 Ferritin-like domain; Region: Ferritin; pfam00210 56107010619 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 56107010620 dinuclear metal binding motif [ion binding]; other site 56107010621 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 56107010622 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 56107010623 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 56107010624 putative ligand binding site [chemical binding]; other site 56107010625 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 56107010626 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 56107010627 GTP binding site; other site 56107010628 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 56107010629 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 56107010630 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 56107010631 protein binding surface [polypeptide binding]; other site 56107010632 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 56107010633 protein binding surface [polypeptide binding]; other site 56107010634 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 56107010635 protein binding surface [polypeptide binding]; other site 56107010636 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 56107010637 protein binding surface [polypeptide binding]; other site 56107010638 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 56107010639 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 56107010640 putative active site [active] 56107010641 putative metal binding site [ion binding]; other site 56107010642 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 56107010643 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 56107010644 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 56107010645 catalytic residues [active] 56107010646 Clp protease; Region: CLP_protease; pfam00574 56107010647 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 56107010648 oligomer interface [polypeptide binding]; other site 56107010649 active site residues [active] 56107010650 Exoribonuclease R [Transcription]; Region: VacB; COG0557 56107010651 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 56107010652 RNB domain; Region: RNB; pfam00773 56107010653 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 56107010654 RNA binding site [nucleotide binding]; other site 56107010655 aromatic acid decarboxylase; Validated; Region: PRK05920 56107010656 Flavoprotein; Region: Flavoprotein; pfam02441 56107010657 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 56107010658 AAA ATPase domain; Region: AAA_16; pfam13191 56107010659 shikimate kinase; Reviewed; Region: aroK; PRK00131 56107010660 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 56107010661 ADP binding site [chemical binding]; other site 56107010662 magnesium binding site [ion binding]; other site 56107010663 putative shikimate binding site; other site 56107010664 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 56107010665 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 56107010666 putative ligand binding site [chemical binding]; other site 56107010667 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 56107010668 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 56107010669 feedback inhibition sensing region; other site 56107010670 homohexameric interface [polypeptide binding]; other site 56107010671 nucleotide binding site [chemical binding]; other site 56107010672 N-acetyl-L-glutamate binding site [chemical binding]; other site 56107010673 TPR repeat; Region: TPR_11; pfam13414 56107010674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107010675 binding surface 56107010676 TPR motif; other site 56107010677 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 56107010678 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 56107010679 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 56107010680 Integrase core domain; Region: rve; pfam00665 56107010681 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 56107010682 TniQ; Region: TniQ; pfam06527 56107010683 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107010684 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 56107010685 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 56107010686 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 56107010687 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 56107010688 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 56107010689 Domain of unknown function DUF20; Region: UPF0118; pfam01594 56107010690 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 56107010691 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 56107010692 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 56107010693 active site 56107010694 Substrate binding site; other site 56107010695 Mg++ binding site; other site 56107010696 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 56107010697 putative trimer interface [polypeptide binding]; other site 56107010698 putative CoA binding site [chemical binding]; other site 56107010699 arginine decarboxylase; Provisional; Region: PRK05354 56107010700 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 56107010701 dimer interface [polypeptide binding]; other site 56107010702 active site 56107010703 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 56107010704 catalytic residues [active] 56107010705 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 56107010706 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 56107010707 active site 56107010708 multimer interface [polypeptide binding]; other site 56107010709 Integral membrane protein TerC family; Region: TerC; cl10468 56107010710 salicylate synthase MbtI; Reviewed; Region: PRK07912 56107010711 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 56107010712 acetyl-CoA synthetase; Provisional; Region: PRK00174 56107010713 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 56107010714 active site 56107010715 CoA binding site [chemical binding]; other site 56107010716 acyl-activating enzyme (AAE) consensus motif; other site 56107010717 AMP binding site [chemical binding]; other site 56107010718 acetate binding site [chemical binding]; other site 56107010719 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 56107010720 Predicted ATPase [General function prediction only]; Region: COG5293 56107010721 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 56107010722 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 56107010723 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 56107010724 short chain dehydrogenase; Provisional; Region: PRK06914 56107010725 NADP binding site [chemical binding]; other site 56107010726 active site 56107010727 steroid binding site; other site 56107010728 H+ Antiporter protein; Region: 2A0121; TIGR00900 56107010729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107010730 putative substrate translocation pore; other site 56107010731 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 56107010732 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 56107010733 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 56107010734 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 56107010735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107010736 Bacterial SH3 domain; Region: SH3_3; cl17532 56107010737 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 56107010738 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 56107010739 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 56107010740 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 56107010741 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 56107010742 active site 56107010743 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 56107010744 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 56107010745 substrate binding site [chemical binding]; other site 56107010746 ATP binding site [chemical binding]; other site 56107010747 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107010748 Predicted methyltransferases [General function prediction only]; Region: COG0313 56107010749 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 56107010750 putative SAM binding site [chemical binding]; other site 56107010751 putative homodimer interface [polypeptide binding]; other site 56107010752 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 56107010753 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 56107010754 putative active site [active] 56107010755 catalytic residue [active] 56107010756 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 56107010757 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 56107010758 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 56107010759 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 56107010760 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 56107010761 active site 56107010762 catalytic site [active] 56107010763 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 56107010764 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 56107010765 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 56107010766 putative acyl-acceptor binding pocket; other site 56107010767 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 56107010768 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 56107010769 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 56107010770 nucleophilic elbow; other site 56107010771 catalytic triad; other site 56107010772 Response regulator receiver domain; Region: Response_reg; pfam00072 56107010773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107010774 active site 56107010775 phosphorylation site [posttranslational modification] 56107010776 intermolecular recognition site; other site 56107010777 dimerization interface [polypeptide binding]; other site 56107010778 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107010779 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107010780 putative active site [active] 56107010781 heme pocket [chemical binding]; other site 56107010782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107010783 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107010784 putative active site [active] 56107010785 heme pocket [chemical binding]; other site 56107010786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107010787 putative active site [active] 56107010788 heme pocket [chemical binding]; other site 56107010789 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107010790 PAS domain; Region: PAS; smart00091 56107010791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107010792 dimer interface [polypeptide binding]; other site 56107010793 phosphorylation site [posttranslational modification] 56107010794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107010795 ATP binding site [chemical binding]; other site 56107010796 Mg2+ binding site [ion binding]; other site 56107010797 G-X-G motif; other site 56107010798 Response regulator receiver domain; Region: Response_reg; pfam00072 56107010799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107010800 active site 56107010801 phosphorylation site [posttranslational modification] 56107010802 intermolecular recognition site; other site 56107010803 dimerization interface [polypeptide binding]; other site 56107010804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107010805 phosphorylation site [posttranslational modification] 56107010806 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107010807 GAF domain; Region: GAF_3; pfam13492 56107010808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107010809 dimer interface [polypeptide binding]; other site 56107010810 phosphorylation site [posttranslational modification] 56107010811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107010812 ATP binding site [chemical binding]; other site 56107010813 Mg2+ binding site [ion binding]; other site 56107010814 G-X-G motif; other site 56107010815 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 56107010816 Cadmium resistance transporter; Region: Cad; pfam03596 56107010817 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 56107010818 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107010819 substrate binding pocket [chemical binding]; other site 56107010820 membrane-bound complex binding site; other site 56107010821 hinge residues; other site 56107010822 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 56107010823 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 56107010824 trmE is a tRNA modification GTPase; Region: trmE; cd04164 56107010825 G1 box; other site 56107010826 GTP/Mg2+ binding site [chemical binding]; other site 56107010827 Switch I region; other site 56107010828 G2 box; other site 56107010829 Switch II region; other site 56107010830 G3 box; other site 56107010831 G4 box; other site 56107010832 G5 box; other site 56107010833 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 56107010834 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107010835 putative active site [active] 56107010836 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107010837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107010838 S-adenosylmethionine binding site [chemical binding]; other site 56107010839 conserved hypothetical protein; Region: TIGR02231 56107010840 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 56107010841 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 56107010842 Transcriptional regulator [Transcription]; Region: LysR; COG0583 56107010843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 56107010844 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 56107010845 putative dimerization interface [polypeptide binding]; other site 56107010846 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 56107010847 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 56107010848 Hexamer interface [polypeptide binding]; other site 56107010849 Hexagonal pore residue; other site 56107010850 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 56107010851 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 56107010852 Hexamer interface [polypeptide binding]; other site 56107010853 Hexagonal pore residue; other site 56107010854 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 56107010855 putative trimer interface [polypeptide binding]; other site 56107010856 putative CoA binding site [chemical binding]; other site 56107010857 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 56107010858 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 56107010859 trimer interface [polypeptide binding]; other site 56107010860 active site 56107010861 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 56107010862 putative multimerization interface [polypeptide binding]; other site 56107010863 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 56107010864 putative multimerization interface [polypeptide binding]; other site 56107010865 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 56107010866 putative multimerization interface [polypeptide binding]; other site 56107010867 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 56107010868 Hexamer/Pentamer interface [polypeptide binding]; other site 56107010869 central pore; other site 56107010870 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 56107010871 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 56107010872 Hexamer interface [polypeptide binding]; other site 56107010873 Hexagonal pore residue; other site 56107010874 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 56107010875 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 56107010876 Hexamer interface [polypeptide binding]; other site 56107010877 Hexagonal pore residue; other site 56107010878 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 56107010879 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 56107010880 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 56107010881 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 56107010882 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 56107010883 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 56107010884 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 56107010885 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 56107010886 Predicted transcriptional regulator [Transcription]; Region: COG3905 56107010887 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 56107010888 Uncharacterized conserved protein [Function unknown]; Region: COG4938 56107010889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107010890 Walker A/P-loop; other site 56107010891 ATP binding site [chemical binding]; other site 56107010892 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 56107010893 Protein of unknown function DUF262; Region: DUF262; pfam03235 56107010894 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 56107010895 FAD binding site [chemical binding]; other site 56107010896 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 56107010897 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 56107010898 active site 56107010899 HIGH motif; other site 56107010900 dimer interface [polypeptide binding]; other site 56107010901 KMSKS motif; other site 56107010902 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 56107010903 NB-ARC domain; Region: NB-ARC; pfam00931 56107010904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107010905 binding surface 56107010906 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107010907 TPR motif; other site 56107010908 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107010909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107010910 binding surface 56107010911 TPR motif; other site 56107010912 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107010913 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107010914 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 56107010915 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 56107010916 B12 binding site [chemical binding]; other site 56107010917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107010918 FeS/SAM binding site; other site 56107010919 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 56107010920 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 56107010921 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 56107010922 putative homodimer interface [polypeptide binding]; other site 56107010923 putative active site pocket [active] 56107010924 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 56107010925 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 56107010926 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 56107010927 trimer interface [polypeptide binding]; other site 56107010928 active site 56107010929 substrate binding site [chemical binding]; other site 56107010930 CoA binding site [chemical binding]; other site 56107010931 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 56107010932 OstA-like protein; Region: OstA; cl00844 56107010933 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 56107010934 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107010935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107010936 active site 56107010937 phosphorylation site [posttranslational modification] 56107010938 intermolecular recognition site; other site 56107010939 dimerization interface [polypeptide binding]; other site 56107010940 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107010941 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107010942 putative active site [active] 56107010943 heme pocket [chemical binding]; other site 56107010944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107010945 dimer interface [polypeptide binding]; other site 56107010946 phosphorylation site [posttranslational modification] 56107010947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107010948 ATP binding site [chemical binding]; other site 56107010949 Mg2+ binding site [ion binding]; other site 56107010950 G-X-G motif; other site 56107010951 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107010952 GAF domain; Region: GAF; pfam01590 56107010953 PAS domain S-box; Region: sensory_box; TIGR00229 56107010954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107010955 putative active site [active] 56107010956 heme pocket [chemical binding]; other site 56107010957 PAS domain S-box; Region: sensory_box; TIGR00229 56107010958 PAS domain; Region: PAS; smart00091 56107010959 putative active site [active] 56107010960 heme pocket [chemical binding]; other site 56107010961 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107010962 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107010963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 56107010964 Histidine kinase; Region: HisKA_2; pfam07568 56107010965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107010966 ATP binding site [chemical binding]; other site 56107010967 Mg2+ binding site [ion binding]; other site 56107010968 G-X-G motif; other site 56107010969 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 56107010970 NADPH bind site [chemical binding]; other site 56107010971 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 56107010972 putative FMN binding site [chemical binding]; other site 56107010973 NADPH bind site [chemical binding]; other site 56107010974 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 56107010975 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 56107010976 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107010977 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107010978 active site 56107010979 substrate binding site [chemical binding]; other site 56107010980 ATP binding site [chemical binding]; other site 56107010981 activation loop (A-loop); other site 56107010982 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 56107010983 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 56107010984 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 56107010985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107010986 Walker A/P-loop; other site 56107010987 ATP binding site [chemical binding]; other site 56107010988 Q-loop/lid; other site 56107010989 ABC transporter signature motif; other site 56107010990 Walker B; other site 56107010991 D-loop; other site 56107010992 H-loop/switch region; other site 56107010993 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 56107010994 ABC1 family; Region: ABC1; cl17513 56107010995 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 56107010996 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 56107010997 Substrate binding site; other site 56107010998 Cupin domain; Region: Cupin_2; cl17218 56107010999 Transcriptional regulator [Transcription]; Region: LytR; COG1316 56107011000 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 56107011001 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107011002 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107011003 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107011004 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 56107011005 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 56107011006 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 56107011007 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 56107011008 AAA domain; Region: AAA_21; pfam13304 56107011009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107011010 Walker B; other site 56107011011 D-loop; other site 56107011012 H-loop/switch region; other site 56107011013 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 56107011014 Agenet domain; Region: Agenet; pfam05641 56107011015 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 56107011016 Protein of unknown function DUF89; Region: DUF89; pfam01937 56107011017 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 56107011018 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 56107011019 active site 56107011020 metal binding site [ion binding]; metal-binding site 56107011021 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 56107011022 Methyltransferase domain; Region: Methyltransf_23; pfam13489 56107011023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107011024 S-adenosylmethionine binding site [chemical binding]; other site 56107011025 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 56107011026 DNA polymerase III subunit delta; Validated; Region: PRK07452 56107011027 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 56107011028 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 56107011029 RDD family; Region: RDD; pfam06271 56107011030 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 56107011031 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 56107011032 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 56107011033 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 56107011034 acyl-activating enzyme (AAE) consensus motif; other site 56107011035 acyl-activating enzyme (AAE) consensus motif; other site 56107011036 putative AMP binding site [chemical binding]; other site 56107011037 putative active site [active] 56107011038 putative CoA binding site [chemical binding]; other site 56107011039 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 56107011040 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107011041 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107011042 acyl-activating enzyme (AAE) consensus motif; other site 56107011043 AMP binding site [chemical binding]; other site 56107011044 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107011045 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107011046 FcoT-like thioesterase domain; Region: FcoT; pfam10862 56107011047 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 56107011048 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 56107011049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107011050 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 56107011051 putative substrate translocation pore; other site 56107011052 H+ Antiporter protein; Region: 2A0121; TIGR00900 56107011053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107011054 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 56107011055 Protein of unknown function DUF58; Region: DUF58; pfam01882 56107011056 von Willebrand factor type A domain; Region: VWA_2; pfam13519 56107011057 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 56107011058 MoxR-like ATPases [General function prediction only]; Region: COG0714 56107011059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107011060 Walker A motif; other site 56107011061 ATP binding site [chemical binding]; other site 56107011062 Walker B motif; other site 56107011063 arginine finger; other site 56107011064 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 56107011065 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 56107011066 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 56107011067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 56107011068 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107011069 GAF domain; Region: GAF; pfam01590 56107011070 Phytochrome region; Region: PHY; pfam00360 56107011071 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107011072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107011073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 56107011074 dimer interface [polypeptide binding]; other site 56107011075 phosphorylation site [posttranslational modification] 56107011076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107011077 ATP binding site [chemical binding]; other site 56107011078 Mg2+ binding site [ion binding]; other site 56107011079 G-X-G motif; other site 56107011080 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 56107011081 MltA specific insert domain; Region: MltA; pfam03562 56107011082 3D domain; Region: 3D; pfam06725 56107011083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107011084 Probable transposase; Region: OrfB_IS605; pfam01385 56107011085 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107011086 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 56107011087 Uncharacterized conserved protein (DUF2349); Region: DUF2349; pfam09779 56107011088 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 56107011089 catalytic motif [active] 56107011090 Catalytic residue [active] 56107011091 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 56107011092 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 56107011093 active site 56107011094 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 56107011095 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 56107011096 dimerization interface [polypeptide binding]; other site 56107011097 putative ATP binding site [chemical binding]; other site 56107011098 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 56107011099 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 56107011100 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 56107011101 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 56107011102 Pantoate-beta-alanine ligase; Region: PanC; cd00560 56107011103 active site 56107011104 ATP-binding site [chemical binding]; other site 56107011105 pantoate-binding site; other site 56107011106 HXXH motif; other site 56107011107 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 56107011108 CMP-binding site; other site 56107011109 The sites determining sugar specificity; other site 56107011110 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 56107011111 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 56107011112 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 56107011113 glutaminase A; Region: Gln_ase; TIGR03814 56107011114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 56107011115 putative DNA binding site [nucleotide binding]; other site 56107011116 putative Zn2+ binding site [ion binding]; other site 56107011117 TPR repeat; Region: TPR_11; pfam13414 56107011118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011119 binding surface 56107011120 TPR motif; other site 56107011121 TPR repeat; Region: TPR_11; pfam13414 56107011122 TPR repeat; Region: TPR_11; pfam13414 56107011123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011124 binding surface 56107011125 TPR motif; other site 56107011126 TPR repeat; Region: TPR_11; pfam13414 56107011127 TPR repeat; Region: TPR_11; pfam13414 56107011128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011129 binding surface 56107011130 TPR motif; other site 56107011131 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 56107011132 FOG: WD40-like repeat [Function unknown]; Region: COG1520 56107011133 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 56107011134 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 56107011135 aspartate-rich region 2; other site 56107011136 substrate-Mg2+ binding site; other site 56107011137 S-layer homology domain; Region: SLH; pfam00395 56107011138 S-layer homology domain; Region: SLH; pfam00395 56107011139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 56107011140 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 56107011141 CHAT domain; Region: CHAT; cl17868 56107011142 TIR domain; Region: TIR_2; pfam13676 56107011143 TIR domain; Region: TIR_2; pfam13676 56107011144 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 56107011145 CHASE2 domain; Region: CHASE2; pfam05226 56107011146 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 56107011147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 56107011148 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 56107011149 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 56107011150 Surface antigen; Region: Bac_surface_Ag; pfam01103 56107011151 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 56107011152 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 56107011153 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 56107011154 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 56107011155 Nucleoside recognition; Region: Gate; pfam07670 56107011156 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 56107011157 Protein kinase domain; Region: Pkinase; pfam00069 56107011158 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107011159 active site 56107011160 ATP binding site [chemical binding]; other site 56107011161 substrate binding site [chemical binding]; other site 56107011162 activation loop (A-loop); other site 56107011163 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 56107011164 AAA ATPase domain; Region: AAA_16; pfam13191 56107011165 Predicted ATPase [General function prediction only]; Region: COG3899 56107011166 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107011167 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107011168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107011169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107011170 ATP binding site [chemical binding]; other site 56107011171 Mg2+ binding site [ion binding]; other site 56107011172 G-X-G motif; other site 56107011173 metal-dependent hydrolase; Provisional; Region: PRK06380 56107011174 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 56107011175 active site 56107011176 putative substrate binding pocket [chemical binding]; other site 56107011177 Isochorismatase family; Region: Isochorismatase; pfam00857 56107011178 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 56107011179 catalytic triad [active] 56107011180 conserved cis-peptide bond; other site 56107011181 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 56107011182 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 56107011183 Phage Tail Collar Domain; Region: Collar; pfam07484 56107011184 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 56107011185 substrate binding site [chemical binding]; other site 56107011186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 56107011187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 56107011188 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 56107011189 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107011190 DevC protein; Region: devC; TIGR01185 56107011191 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 56107011192 FtsX-like permease family; Region: FtsX; pfam02687 56107011193 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 56107011194 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 56107011195 Walker A/P-loop; other site 56107011196 ATP binding site [chemical binding]; other site 56107011197 Q-loop/lid; other site 56107011198 ABC transporter signature motif; other site 56107011199 Walker B; other site 56107011200 D-loop; other site 56107011201 H-loop/switch region; other site 56107011202 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 56107011203 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 56107011204 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 56107011205 Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229 56107011206 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107011207 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107011208 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107011209 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107011210 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107011211 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107011212 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 56107011213 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107011214 Substrate binding site [chemical binding]; other site 56107011215 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107011216 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107011217 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 56107011218 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 56107011219 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 56107011220 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 56107011221 acyl-activating enzyme (AAE) consensus motif; other site 56107011222 acyl-activating enzyme (AAE) consensus motif; other site 56107011223 putative AMP binding site [chemical binding]; other site 56107011224 putative active site [active] 56107011225 putative CoA binding site [chemical binding]; other site 56107011226 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107011227 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 56107011228 Ion channel; Region: Ion_trans_2; pfam07885 56107011229 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 56107011230 TrkA-N domain; Region: TrkA_N; pfam02254 56107011231 TrkA-C domain; Region: TrkA_C; pfam02080 56107011232 acetylornithine aminotransferase; Provisional; Region: PRK02627 56107011233 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 56107011234 inhibitor-cofactor binding pocket; inhibition site 56107011235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107011236 catalytic residue [active] 56107011237 Response regulator receiver domain; Region: Response_reg; pfam00072 56107011238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107011239 active site 56107011240 phosphorylation site [posttranslational modification] 56107011241 intermolecular recognition site; other site 56107011242 dimerization interface [polypeptide binding]; other site 56107011243 PAS fold; Region: PAS_7; pfam12860 56107011244 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 56107011245 cyclase homology domain; Region: CHD; cd07302 56107011246 nucleotidyl binding site; other site 56107011247 metal binding site [ion binding]; metal-binding site 56107011248 dimer interface [polypeptide binding]; other site 56107011249 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 56107011250 Glycoprotease family; Region: Peptidase_M22; pfam00814 56107011251 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 56107011252 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 56107011253 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 56107011254 active site 56107011255 NTP binding site [chemical binding]; other site 56107011256 metal binding triad [ion binding]; metal-binding site 56107011257 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 56107011258 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 56107011259 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 56107011260 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 56107011261 active site 56107011262 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 56107011263 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 56107011264 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107011265 putative active site [active] 56107011266 YcfA-like protein; Region: YcfA; pfam07927 56107011267 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 56107011268 magnesium chelatase subunit H; Provisional; Region: PLN03241 56107011269 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 56107011270 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 56107011271 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 56107011272 active site 56107011273 metal binding site [ion binding]; metal-binding site 56107011274 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 56107011275 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107011276 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107011277 Uncharacterized conserved protein [Function unknown]; Region: COG5607 56107011278 glycerol kinase; Provisional; Region: glpK; PRK00047 56107011279 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 56107011280 N- and C-terminal domain interface [polypeptide binding]; other site 56107011281 active site 56107011282 MgATP binding site [chemical binding]; other site 56107011283 catalytic site [active] 56107011284 metal binding site [ion binding]; metal-binding site 56107011285 putative homotetramer interface [polypeptide binding]; other site 56107011286 glycerol binding site [chemical binding]; other site 56107011287 homodimer interface [polypeptide binding]; other site 56107011288 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 56107011289 4Fe-4S binding domain; Region: Fer4; pfam00037 56107011290 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 56107011291 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 56107011292 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 56107011293 catalytic residues [active] 56107011294 putative sialic acid transporter; Region: 2A0112; TIGR00891 56107011295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107011296 putative substrate translocation pore; other site 56107011297 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 56107011298 heme-binding site [chemical binding]; other site 56107011299 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 56107011300 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 56107011301 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 56107011302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 56107011303 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 56107011304 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 56107011305 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 56107011306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 56107011307 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 56107011308 anti sigma factor interaction site; other site 56107011309 regulatory phosphorylation site [posttranslational modification]; other site 56107011310 Mechanosensitive ion channel; Region: MS_channel; pfam00924 56107011311 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 56107011312 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 56107011313 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 56107011314 active site 56107011315 homodimer interface [polypeptide binding]; other site 56107011316 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 56107011317 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 56107011318 putative NAD(P) binding site [chemical binding]; other site 56107011319 homodimer interface [polypeptide binding]; other site 56107011320 homotetramer interface [polypeptide binding]; other site 56107011321 active site 56107011322 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 56107011323 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 56107011324 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 56107011325 NADP binding site [chemical binding]; other site 56107011326 substrate binding site [chemical binding]; other site 56107011327 active site 56107011328 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 56107011329 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 56107011330 active site 56107011331 Zn binding site [ion binding]; other site 56107011332 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 56107011333 Ligand Binding Site [chemical binding]; other site 56107011334 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 56107011335 Ligand Binding Site [chemical binding]; other site 56107011336 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 56107011337 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 56107011338 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 56107011339 catalytic loop [active] 56107011340 iron binding site [ion binding]; other site 56107011341 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 56107011342 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 56107011343 cobalamin synthase; Reviewed; Region: cobS; PRK00235 56107011344 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 56107011345 comF family protein; Region: comF; TIGR00201 56107011346 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 56107011347 active site 56107011348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107011349 Coenzyme A binding pocket [chemical binding]; other site 56107011350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107011351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107011352 ATP binding site [chemical binding]; other site 56107011353 Mg2+ binding site [ion binding]; other site 56107011354 G-X-G motif; other site 56107011355 UV-endonuclease UvdE; Region: UvdE; cl10036 56107011356 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 56107011357 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 56107011358 nucleotide binding site [chemical binding]; other site 56107011359 putative NEF/HSP70 interaction site [polypeptide binding]; other site 56107011360 SBD interface [polypeptide binding]; other site 56107011361 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 56107011362 RNA binding surface [nucleotide binding]; other site 56107011363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 56107011364 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 56107011365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 56107011366 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 56107011367 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 56107011368 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 56107011369 active site 56107011370 intersubunit interface [polypeptide binding]; other site 56107011371 catalytic residue [active] 56107011372 Erythromycin esterase; Region: Erythro_esteras; pfam05139 56107011373 chaperone protein DnaJ; Provisional; Region: PRK14299 56107011374 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107011375 HSP70 interaction site [polypeptide binding]; other site 56107011376 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 56107011377 substrate binding site [polypeptide binding]; other site 56107011378 dimer interface [polypeptide binding]; other site 56107011379 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 56107011380 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 56107011381 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 56107011382 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 56107011383 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 56107011384 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 56107011385 HEAT repeats; Region: HEAT_2; pfam13646 56107011386 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 56107011387 Glucuronate isomerase; Region: UxaC; cl00829 56107011388 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107011389 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 56107011390 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 56107011391 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 56107011392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107011393 Coenzyme A binding pocket [chemical binding]; other site 56107011394 transketolase; Reviewed; Region: PRK05899 56107011395 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 56107011396 TPP-binding site [chemical binding]; other site 56107011397 dimer interface [polypeptide binding]; other site 56107011398 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 56107011399 PYR/PP interface [polypeptide binding]; other site 56107011400 dimer interface [polypeptide binding]; other site 56107011401 TPP binding site [chemical binding]; other site 56107011402 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 56107011403 PRC-barrel domain; Region: PRC; pfam05239 56107011404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 56107011405 PRC-barrel domain; Region: PRC; pfam05239 56107011406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 56107011407 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 56107011408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107011409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 56107011410 putative substrate translocation pore; other site 56107011411 Inward rectifier potassium channel; Region: IRK; pfam01007 56107011412 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 56107011413 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 56107011414 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 56107011415 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 56107011416 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 56107011417 putative binding surface; other site 56107011418 active site 56107011419 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 56107011420 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 56107011421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107011422 ATP binding site [chemical binding]; other site 56107011423 Mg2+ binding site [ion binding]; other site 56107011424 G-X-G motif; other site 56107011425 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 56107011426 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107011427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107011428 active site 56107011429 phosphorylation site [posttranslational modification] 56107011430 intermolecular recognition site; other site 56107011431 dimerization interface [polypeptide binding]; other site 56107011432 Cache domain; Region: Cache_1; pfam02743 56107011433 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107011434 dimerization interface [polypeptide binding]; other site 56107011435 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107011436 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107011437 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 56107011438 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 56107011439 dimer interface [polypeptide binding]; other site 56107011440 putative CheW interface [polypeptide binding]; other site 56107011441 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 56107011442 Response regulator receiver domain; Region: Response_reg; pfam00072 56107011443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107011444 active site 56107011445 phosphorylation site [posttranslational modification] 56107011446 intermolecular recognition site; other site 56107011447 dimerization interface [polypeptide binding]; other site 56107011448 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 56107011449 Response regulator receiver domain; Region: Response_reg; pfam00072 56107011450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107011451 active site 56107011452 phosphorylation site [posttranslational modification] 56107011453 intermolecular recognition site; other site 56107011454 dimerization interface [polypeptide binding]; other site 56107011455 HEAT repeats; Region: HEAT_2; pfam13646 56107011456 HEAT repeats; Region: HEAT_2; pfam13646 56107011457 HEAT repeats; Region: HEAT_2; pfam13646 56107011458 HEAT repeats; Region: HEAT_2; pfam13646 56107011459 HEAT repeats; Region: HEAT_2; pfam13646 56107011460 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 56107011461 active site 56107011462 catalytic residues [active] 56107011463 alanine racemase; Reviewed; Region: alr; PRK00053 56107011464 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 56107011465 active site 56107011466 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 56107011467 dimer interface [polypeptide binding]; other site 56107011468 substrate binding site [chemical binding]; other site 56107011469 catalytic residues [active] 56107011470 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107011471 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107011472 active site 56107011473 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 56107011474 DHH family; Region: DHH; pfam01368 56107011475 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107011476 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 56107011477 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 56107011478 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 56107011479 catalytic core [active] 56107011480 citrate synthase; Provisional; Region: PRK14036 56107011481 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 56107011482 dimer interface [polypeptide binding]; other site 56107011483 active site 56107011484 citrylCoA binding site [chemical binding]; other site 56107011485 oxalacetate/citrate binding site [chemical binding]; other site 56107011486 coenzyme A binding site [chemical binding]; other site 56107011487 catalytic triad [active] 56107011488 NADH dehydrogenase subunit 1; Region: ndhA; CHL00032 56107011489 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 56107011490 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 56107011491 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 56107011492 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 56107011493 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 56107011494 NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015 56107011495 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 56107011496 ATP-NAD kinase; Region: NAD_kinase; pfam01513 56107011497 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 56107011498 Predicted membrane protein [Function unknown]; Region: COG5305 56107011499 Electron transfer DM13; Region: DM13; pfam10517 56107011500 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 56107011501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107011502 dimer interface [polypeptide binding]; other site 56107011503 phosphorylation site [posttranslational modification] 56107011504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107011505 ATP binding site [chemical binding]; other site 56107011506 Mg2+ binding site [ion binding]; other site 56107011507 G-X-G motif; other site 56107011508 AAA domain; Region: AAA_33; pfam13671 56107011509 AAA domain; Region: AAA_17; pfam13207 56107011510 WYL domain; Region: WYL; pfam13280 56107011511 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 56107011512 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 56107011513 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 56107011514 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 56107011515 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 56107011516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107011517 Coenzyme A binding pocket [chemical binding]; other site 56107011518 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 56107011519 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107011520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107011521 active site 56107011522 phosphorylation site [posttranslational modification] 56107011523 intermolecular recognition site; other site 56107011524 dimerization interface [polypeptide binding]; other site 56107011525 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107011526 DNA binding site [nucleotide binding] 56107011527 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107011528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107011529 S-adenosylmethionine binding site [chemical binding]; other site 56107011530 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 56107011531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107011532 FeS/SAM binding site; other site 56107011533 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 56107011534 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 56107011535 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 56107011536 putative NAD(P) binding site [chemical binding]; other site 56107011537 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 56107011538 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 56107011539 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 56107011540 Chain length determinant protein; Region: Wzz; cl15801 56107011541 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 56107011542 Chain length determinant protein; Region: Wzz; cl15801 56107011543 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 56107011544 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107011545 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 56107011546 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 56107011547 inhibitor-cofactor binding pocket; inhibition site 56107011548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107011549 catalytic residue [active] 56107011550 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 56107011551 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 56107011552 Bacterial sugar transferase; Region: Bac_transf; pfam02397 56107011553 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 56107011554 putative ADP-binding pocket [chemical binding]; other site 56107011555 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107011556 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 56107011557 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 56107011558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107011559 NAD(P) binding site [chemical binding]; other site 56107011560 active site 56107011561 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107011562 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 56107011563 putative ADP-binding pocket [chemical binding]; other site 56107011564 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107011565 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 56107011566 putative ADP-binding pocket [chemical binding]; other site 56107011567 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107011568 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 56107011569 putative ADP-binding pocket [chemical binding]; other site 56107011570 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 56107011571 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107011572 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 56107011573 putative ADP-binding pocket [chemical binding]; other site 56107011574 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 56107011575 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 56107011576 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 56107011577 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 56107011578 NAD(P) binding site [chemical binding]; other site 56107011579 homodimer interface [polypeptide binding]; other site 56107011580 substrate binding site [chemical binding]; other site 56107011581 active site 56107011582 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 56107011583 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 56107011584 putative valine binding site [chemical binding]; other site 56107011585 dimer interface [polypeptide binding]; other site 56107011586 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 56107011587 outer membrane lipoprotein; Provisional; Region: PRK11023 56107011588 hydrolase, alpha/beta fold family protein; Region: PLN02824 56107011589 translation initiation factor 3; Provisional; Region: infC; CHL00199 56107011590 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 56107011591 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 56107011592 TLC ATP/ADP transporter; Region: TLC; cl03940 56107011593 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 56107011594 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 56107011595 glucose-1-dehydrogenase; Provisional; Region: PRK08936 56107011596 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 56107011597 NAD binding site [chemical binding]; other site 56107011598 homodimer interface [polypeptide binding]; other site 56107011599 active site 56107011600 YcfA-like protein; Region: YcfA; cl00752 56107011601 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 56107011602 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 56107011603 hypothetical protein; Provisional; Region: PRK02509 56107011604 Uncharacterized conserved protein [Function unknown]; Region: COG1615 56107011605 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107011606 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107011607 ligand binding site [chemical binding]; other site 56107011608 flexible hinge region; other site 56107011609 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 56107011610 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107011611 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 56107011612 catalytic triad [active] 56107011613 Mannan-binding protein; Region: MVL; pfam12151 56107011614 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 56107011615 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107011616 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 56107011617 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 56107011618 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 56107011619 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 56107011620 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 56107011621 putative active site [active] 56107011622 transaldolase; Provisional; Region: PRK03903 56107011623 catalytic residue [active] 56107011624 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 56107011625 AMP binding site [chemical binding]; other site 56107011626 metal binding site [ion binding]; metal-binding site 56107011627 active site 56107011628 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 56107011629 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 56107011630 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 56107011631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107011632 Coenzyme A binding pocket [chemical binding]; other site 56107011633 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 56107011634 Udp N-acetylglucosamine O-acyltransferase; Domain 2; Region: Acetyltransf_11; pfam13720 56107011635 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 56107011636 EF-hand domain pair; Region: EF_hand_5; pfam13499 56107011637 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 56107011638 Ca2+ binding site [ion binding]; other site 56107011639 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 56107011640 Ca2+ binding site [ion binding]; other site 56107011641 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 56107011642 pseudo EF-hand loop; other site 56107011643 peptide binding pocket; other site 56107011644 Ca2+ binding site [ion binding]; other site 56107011645 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 56107011646 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 56107011647 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 56107011648 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 56107011649 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 56107011650 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 56107011651 trimer interface [polypeptide binding]; other site 56107011652 active site 56107011653 substrate binding site [chemical binding]; other site 56107011654 CoA binding site [chemical binding]; other site 56107011655 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 56107011656 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 56107011657 active site residue [active] 56107011658 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 56107011659 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 56107011660 Fatty acid desaturase; Region: FA_desaturase; pfam00487 56107011661 putative di-iron ligands [ion binding]; other site 56107011662 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 56107011663 classical (c) SDRs; Region: SDR_c; cd05233 56107011664 NAD(P) binding site [chemical binding]; other site 56107011665 active site 56107011666 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 56107011667 putative hydrophobic ligand binding site [chemical binding]; other site 56107011668 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 56107011669 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 56107011670 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 56107011671 B12 binding site [chemical binding]; other site 56107011672 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 56107011673 FeS/SAM binding site; other site 56107011674 Uncharacterized conserved protein [Function unknown]; Region: COG4095 56107011675 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107011676 putative active site [active] 56107011677 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 56107011678 Predicted ATPase [General function prediction only]; Region: COG4637 56107011679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107011680 Walker A/P-loop; other site 56107011681 ATP binding site [chemical binding]; other site 56107011682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 56107011683 ABC transporter signature motif; other site 56107011684 Walker B; other site 56107011685 D-loop; other site 56107011686 H-loop/switch region; other site 56107011687 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 56107011688 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 56107011689 Tetramer interface [polypeptide binding]; other site 56107011690 active site 56107011691 FMN-binding site [chemical binding]; other site 56107011692 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 56107011693 protein I interface; other site 56107011694 D2 interface; other site 56107011695 protein T interface; other site 56107011696 chlorophyll binding site; other site 56107011697 beta carotene binding site; other site 56107011698 pheophytin binding site; other site 56107011699 manganese-stabilizing polypeptide interface; other site 56107011700 CP43 interface; other site 56107011701 protein L interface; other site 56107011702 oxygen evolving complex binding site; other site 56107011703 bromide binding site; other site 56107011704 quinone binding site; other site 56107011705 Fe binding site [ion binding]; other site 56107011706 core light harvesting interface; other site 56107011707 cytochrome b559 alpha subunit interface; other site 56107011708 cytochrome c-550 interface; other site 56107011709 protein J interface; other site 56107011710 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 56107011711 protein I interface; other site 56107011712 D2 interface; other site 56107011713 protein T interface; other site 56107011714 chlorophyll binding site; other site 56107011715 beta carotene binding site; other site 56107011716 pheophytin binding site; other site 56107011717 manganese-stabilizing polypeptide interface; other site 56107011718 CP43 interface; other site 56107011719 protein L interface; other site 56107011720 oxygen evolving complex binding site; other site 56107011721 bromide binding site; other site 56107011722 quinone binding site; other site 56107011723 Fe binding site [ion binding]; other site 56107011724 core light harvesting interface; other site 56107011725 cytochrome b559 alpha subunit interface; other site 56107011726 cytochrome c-550 interface; other site 56107011727 protein J interface; other site 56107011728 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 56107011729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107011730 FeS/SAM binding site; other site 56107011731 TPR repeat; Region: TPR_11; pfam13414 56107011732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011733 binding surface 56107011734 TPR motif; other site 56107011735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011736 binding surface 56107011737 TPR repeat; Region: TPR_11; pfam13414 56107011738 TPR motif; other site 56107011739 Tetratricopeptide repeat; Region: TPR_16; pfam13432 56107011740 TPR repeat; Region: TPR_11; pfam13414 56107011741 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011742 binding surface 56107011743 TPR motif; other site 56107011744 TPR repeat; Region: TPR_11; pfam13414 56107011745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011746 binding surface 56107011747 TPR motif; other site 56107011748 TPR repeat; Region: TPR_11; pfam13414 56107011749 TPR repeat; Region: TPR_11; pfam13414 56107011750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011751 binding surface 56107011752 TPR motif; other site 56107011753 TPR repeat; Region: TPR_11; pfam13414 56107011754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011755 binding surface 56107011756 TPR repeat; Region: TPR_11; pfam13414 56107011757 TPR motif; other site 56107011758 TPR repeat; Region: TPR_11; pfam13414 56107011759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011760 TPR repeat; Region: TPR_11; pfam13414 56107011761 binding surface 56107011762 TPR motif; other site 56107011763 TPR repeat; Region: TPR_11; pfam13414 56107011764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011765 binding surface 56107011766 TPR motif; other site 56107011767 TPR repeat; Region: TPR_11; pfam13414 56107011768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011769 binding surface 56107011770 TPR motif; other site 56107011771 TPR repeat; Region: TPR_11; pfam13414 56107011772 TPR repeat; Region: TPR_11; pfam13414 56107011773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011774 binding surface 56107011775 TPR motif; other site 56107011776 TPR repeat; Region: TPR_11; pfam13414 56107011777 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 56107011778 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 56107011779 HflX GTPase family; Region: HflX; cd01878 56107011780 G1 box; other site 56107011781 GTP/Mg2+ binding site [chemical binding]; other site 56107011782 Switch I region; other site 56107011783 G2 box; other site 56107011784 G3 box; other site 56107011785 Switch II region; other site 56107011786 G4 box; other site 56107011787 G5 box; other site 56107011788 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 56107011789 GSH binding site [chemical binding]; other site 56107011790 catalytic residues [active] 56107011791 glutathione synthetase; Provisional; Region: PRK05246 56107011792 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 56107011793 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 56107011794 cell division protein FtsZ; Validated; Region: PRK09330 56107011795 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 56107011796 nucleotide binding site [chemical binding]; other site 56107011797 SulA interaction site; other site 56107011798 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 56107011799 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 56107011800 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 56107011801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 56107011802 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107011803 AAA ATPase domain; Region: AAA_16; pfam13191 56107011804 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 56107011805 active site 56107011806 Int/Topo IB signature motif; other site 56107011807 DNA binding site [nucleotide binding] 56107011808 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107011809 WD domain, G-beta repeat; Region: WD40; pfam00400 56107011810 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107011811 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107011812 structural tetrad; other site 56107011813 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107011814 structural tetrad; other site 56107011815 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107011816 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 56107011817 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 56107011818 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 56107011819 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 56107011820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 56107011821 DNA binding residues [nucleotide binding] 56107011822 photosystem II reaction center protein J; Provisional; Region: PRK02565 56107011823 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 56107011824 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 56107011825 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 56107011826 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 56107011827 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 56107011828 Ycf48-like protein; Provisional; Region: PRK13684 56107011829 Rubredoxin [Energy production and conversion]; Region: COG1773 56107011830 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 56107011831 iron binding site [ion binding]; other site 56107011832 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 56107011833 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 56107011834 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 56107011835 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 56107011836 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 56107011837 AAA ATPase domain; Region: AAA_16; pfam13191 56107011838 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107011839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011840 binding surface 56107011841 TPR motif; other site 56107011842 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107011843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011844 binding surface 56107011845 TPR motif; other site 56107011846 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107011847 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107011848 Tetratricopeptide repeat; Region: TPR_10; pfam13374 56107011849 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 56107011850 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 56107011851 Cache domain; Region: Cache_1; pfam02743 56107011852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107011853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107011854 dimerization interface [polypeptide binding]; other site 56107011855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107011856 dimer interface [polypeptide binding]; other site 56107011857 phosphorylation site [posttranslational modification] 56107011858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107011859 ATP binding site [chemical binding]; other site 56107011860 Mg2+ binding site [ion binding]; other site 56107011861 G-X-G motif; other site 56107011862 Response regulator receiver domain; Region: Response_reg; pfam00072 56107011863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107011864 active site 56107011865 phosphorylation site [posttranslational modification] 56107011866 intermolecular recognition site; other site 56107011867 dimerization interface [polypeptide binding]; other site 56107011868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107011869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107011870 dimer interface [polypeptide binding]; other site 56107011871 phosphorylation site [posttranslational modification] 56107011872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107011873 ATP binding site [chemical binding]; other site 56107011874 Mg2+ binding site [ion binding]; other site 56107011875 G-X-G motif; other site 56107011876 Predicted membrane protein [Function unknown]; Region: COG3431 56107011877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011878 binding surface 56107011879 TPR motif; other site 56107011880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011881 binding surface 56107011882 TPR repeat; Region: TPR_11; pfam13414 56107011883 TPR motif; other site 56107011884 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 56107011885 elongation factor G; Reviewed; Region: PRK12740 56107011886 G1 box; other site 56107011887 putative GEF interaction site [polypeptide binding]; other site 56107011888 GTP/Mg2+ binding site [chemical binding]; other site 56107011889 Switch I region; other site 56107011890 G2 box; other site 56107011891 G3 box; other site 56107011892 Switch II region; other site 56107011893 G4 box; other site 56107011894 G5 box; other site 56107011895 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 56107011896 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 56107011897 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 56107011898 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 56107011899 Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; Region: FRQ1; COG5126 56107011900 Ca2+ binding site [ion binding]; other site 56107011901 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 56107011902 Protein of unknown function DUF82; Region: DUF82; pfam01927 56107011903 Protein of unknown function (DUF433); Region: DUF433; cl01030 56107011904 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 56107011905 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 56107011906 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 56107011907 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 56107011908 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 56107011909 protein binding site [polypeptide binding]; other site 56107011910 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 56107011911 Catalytic dyad [active] 56107011912 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 56107011913 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 56107011914 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 56107011915 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 56107011916 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 56107011917 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 56107011918 Coenzyme A binding pocket [chemical binding]; other site 56107011919 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 56107011920 catalytic triad [active] 56107011921 conserved cis-peptide bond; other site 56107011922 TPR repeat; Region: TPR_11; pfam13414 56107011923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011924 binding surface 56107011925 TPR motif; other site 56107011926 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 56107011927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011928 binding surface 56107011929 TPR motif; other site 56107011930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107011931 binding surface 56107011932 TPR motif; other site 56107011933 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 56107011934 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 56107011935 Peptidase family M23; Region: Peptidase_M23; pfam01551 56107011936 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 56107011937 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 56107011938 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 56107011939 protein binding site [polypeptide binding]; other site 56107011940 Protein of unknown function (DUF760); Region: DUF760; pfam05542 56107011941 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 56107011942 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 56107011943 substrate binding site; other site 56107011944 dimer interface; other site 56107011945 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 56107011946 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 56107011947 putative active site [active] 56107011948 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 56107011949 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 56107011950 metal binding site 2 [ion binding]; metal-binding site 56107011951 putative DNA binding helix; other site 56107011952 metal binding site 1 [ion binding]; metal-binding site 56107011953 dimer interface [polypeptide binding]; other site 56107011954 structural Zn2+ binding site [ion binding]; other site 56107011955 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107011956 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107011957 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107011958 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107011959 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 56107011960 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 56107011961 Bacterial sugar transferase; Region: Bac_transf; pfam02397 56107011962 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 56107011963 Right handed beta helix region; Region: Beta_helix; pfam13229 56107011964 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 56107011965 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 56107011966 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 56107011967 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107011968 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107011969 active site 56107011970 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 56107011971 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107011972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107011973 S-adenosylmethionine binding site [chemical binding]; other site 56107011974 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 56107011975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107011976 active site 56107011977 motif I; other site 56107011978 motif II; other site 56107011979 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 56107011980 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 56107011981 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107011982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107011983 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 56107011984 O-Antigen ligase; Region: Wzy_C; cl04850 56107011985 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107011986 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107011987 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 56107011988 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 56107011989 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 56107011990 Chain length determinant protein; Region: Wzz; cl15801 56107011991 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 56107011992 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 56107011993 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107011994 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 56107011995 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 56107011996 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 56107011997 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 56107011998 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 56107011999 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 56107012000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107012001 homodimer interface [polypeptide binding]; other site 56107012002 catalytic residue [active] 56107012003 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 56107012004 IHF dimer interface [polypeptide binding]; other site 56107012005 IHF - DNA interface [nucleotide binding]; other site 56107012006 AMIN domain; Region: AMIN; pfam11741 56107012007 Secretin and TonB N terminus short domain; Region: STN; pfam07660 56107012008 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 56107012009 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 56107012010 Pilus assembly protein, PilO; Region: PilO; cl01234 56107012011 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 56107012012 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 56107012013 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 56107012014 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 56107012015 Cell division protein FtsA; Region: FtsA; cl17206 56107012016 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 56107012017 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 56107012018 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 56107012019 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 56107012020 photosystem II protein Y; Reviewed; Region: pbsY; PRK13240 56107012021 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 56107012022 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 56107012023 trimer interface [polypeptide binding]; other site 56107012024 putative metal binding site [ion binding]; other site 56107012025 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 56107012026 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 56107012027 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 56107012028 active site 56107012029 metal binding site [ion binding]; metal-binding site 56107012030 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 56107012031 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 56107012032 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 56107012033 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 56107012034 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 56107012035 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 56107012036 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 56107012037 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107012038 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 56107012039 active site 56107012040 Hpr binding site; other site 56107012041 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107012042 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 56107012043 active site 56107012044 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 56107012045 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 56107012046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107012047 Walker A/P-loop; other site 56107012048 ATP binding site [chemical binding]; other site 56107012049 Q-loop/lid; other site 56107012050 ABC transporter signature motif; other site 56107012051 Walker B; other site 56107012052 D-loop; other site 56107012053 H-loop/switch region; other site 56107012054 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 56107012055 active site 56107012056 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107012057 Phage-related protein [Function unknown]; Region: COG5412 56107012058 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107012059 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 56107012060 structural tetrad; other site 56107012061 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 56107012062 HEAT repeats; Region: HEAT_2; pfam13646 56107012063 HEAT repeats; Region: HEAT_2; pfam13646 56107012064 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 56107012065 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 56107012066 Amidase; Region: Amidase; pfam01425 56107012067 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 56107012068 active site 56107012069 substrate binding site [chemical binding]; other site 56107012070 catalytic site [active] 56107012071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107012072 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107012073 Probable transposase; Region: OrfB_IS605; pfam01385 56107012074 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107012075 ketol-acid reductoisomerase; Provisional; Region: PRK05479 56107012076 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 56107012077 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 56107012078 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 56107012079 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 56107012080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107012081 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107012082 Probable transposase; Region: OrfB_IS605; pfam01385 56107012083 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107012084 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107012085 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107012086 ligand binding site [chemical binding]; other site 56107012087 flexible hinge region; other site 56107012088 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107012089 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107012090 ligand binding site [chemical binding]; other site 56107012091 flexible hinge region; other site 56107012092 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 56107012093 substrate binding pocket [chemical binding]; other site 56107012094 substrate-Mg2+ binding site; other site 56107012095 aspartate-rich region 1; other site 56107012096 active site lid residues [active] 56107012097 aspartate-rich region 2; other site 56107012098 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 56107012099 substrate binding pocket [chemical binding]; other site 56107012100 substrate-Mg2+ binding site; other site 56107012101 aspartate-rich region 1; other site 56107012102 active site lid residues [active] 56107012103 aspartate-rich region 2; other site 56107012104 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 56107012105 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 56107012106 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 56107012107 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 56107012108 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 56107012109 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 56107012110 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 56107012111 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107012112 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107012113 active site 56107012114 ATP binding site [chemical binding]; other site 56107012115 substrate binding site [chemical binding]; other site 56107012116 activation loop (A-loop); other site 56107012117 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 56107012118 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 56107012119 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 56107012120 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107012121 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107012122 active site 56107012123 ATP binding site [chemical binding]; other site 56107012124 substrate binding site [chemical binding]; other site 56107012125 activation loop (A-loop); other site 56107012126 TfuA-like protein; Region: TfuA; pfam07812 56107012127 Uncharacterized conserved protein [Function unknown]; Region: COG1944 56107012128 YcaO-like family; Region: YcaO; pfam02624 56107012129 SpaB C-terminal domain; Region: SpaB_C; cl14828 56107012130 Cupin-like domain; Region: Cupin_8; pfam13621 56107012131 H+ Antiporter protein; Region: 2A0121; TIGR00900 56107012132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107012133 putative substrate translocation pore; other site 56107012134 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 56107012135 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 56107012136 putative active site [active] 56107012137 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107012138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107012139 Walker A/P-loop; other site 56107012140 ATP binding site [chemical binding]; other site 56107012141 Q-loop/lid; other site 56107012142 ABC transporter signature motif; other site 56107012143 Walker B; other site 56107012144 D-loop; other site 56107012145 H-loop/switch region; other site 56107012146 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 56107012147 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 56107012148 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107012149 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107012150 bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896 56107012151 ligand binding site [chemical binding]; other site 56107012152 flexible hinge region; other site 56107012153 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107012154 ligand binding site [chemical binding]; other site 56107012155 flexible hinge region; other site 56107012156 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 56107012157 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 56107012158 CHASE2 domain; Region: CHASE2; pfam05226 56107012159 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 56107012160 cyclase homology domain; Region: CHD; cd07302 56107012161 nucleotidyl binding site; other site 56107012162 metal binding site [ion binding]; metal-binding site 56107012163 dimer interface [polypeptide binding]; other site 56107012164 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 56107012165 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107012166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107012167 Walker A/P-loop; other site 56107012168 ATP binding site [chemical binding]; other site 56107012169 Q-loop/lid; other site 56107012170 ABC transporter signature motif; other site 56107012171 Walker B; other site 56107012172 D-loop; other site 56107012173 H-loop/switch region; other site 56107012174 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 56107012175 metal binding site [ion binding]; metal-binding site 56107012176 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 56107012177 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 56107012178 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 56107012179 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 56107012180 ATP binding site [chemical binding]; other site 56107012181 Mg++ binding site [ion binding]; other site 56107012182 motif III; other site 56107012183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107012184 nucleotide binding region [chemical binding]; other site 56107012185 ATP-binding site [chemical binding]; other site 56107012186 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107012187 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 56107012188 active site 56107012189 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107012190 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107012191 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 56107012192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107012193 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 56107012194 Enoylreductase; Region: PKS_ER; smart00829 56107012195 NAD(P) binding site [chemical binding]; other site 56107012196 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 56107012197 KR domain; Region: KR; pfam08659 56107012198 putative NADP binding site [chemical binding]; other site 56107012199 active site 56107012200 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107012201 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107012202 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107012203 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107012204 acyl-activating enzyme (AAE) consensus motif; other site 56107012205 AMP binding site [chemical binding]; other site 56107012206 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107012207 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 56107012208 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 56107012209 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 56107012210 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 56107012211 TPP-binding site [chemical binding]; other site 56107012212 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 56107012213 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 56107012214 Cytochrome P450; Region: p450; cl12078 56107012215 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 56107012216 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 56107012217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107012218 Protein of unknown function DUF262; Region: DUF262; pfam03235 56107012219 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107012220 active site 56107012221 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 56107012222 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 56107012223 catalytic residues [active] 56107012224 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 56107012225 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 56107012226 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 56107012227 Cytochrome P450; Region: p450; cl12078 56107012228 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 56107012229 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 56107012230 active site 56107012231 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 56107012232 Cysteine-rich domain; Region: CCG; pfam02754 56107012233 Cysteine-rich domain; Region: CCG; pfam02754 56107012234 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 56107012235 FAD binding domain; Region: FAD_binding_4; pfam01565 56107012236 alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional; Region: PLN03063 56107012237 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107012238 putative active site [active] 56107012239 NADH dehydrogenase subunit 5; Provisional; Region: ND5; MTH00210 56107012240 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 56107012241 Response regulator receiver domain; Region: Response_reg; pfam00072 56107012242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107012243 active site 56107012244 phosphorylation site [posttranslational modification] 56107012245 intermolecular recognition site; other site 56107012246 dimerization interface [polypeptide binding]; other site 56107012247 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 56107012248 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 56107012249 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 56107012250 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 56107012251 anti sigma factor interaction site; other site 56107012252 regulatory phosphorylation site [posttranslational modification]; other site 56107012253 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107012254 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107012255 putative active site [active] 56107012256 heme pocket [chemical binding]; other site 56107012257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 56107012258 putative active site [active] 56107012259 heme pocket [chemical binding]; other site 56107012260 PAS fold; Region: PAS_4; pfam08448 56107012261 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107012262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107012263 putative active site [active] 56107012264 heme pocket [chemical binding]; other site 56107012265 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 56107012266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107012267 putative active site [active] 56107012268 heme pocket [chemical binding]; other site 56107012269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107012270 dimer interface [polypeptide binding]; other site 56107012271 phosphorylation site [posttranslational modification] 56107012272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107012273 ATP binding site [chemical binding]; other site 56107012274 Mg2+ binding site [ion binding]; other site 56107012275 G-X-G motif; other site 56107012276 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 56107012277 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 56107012278 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 56107012279 ParB-like nuclease domain; Region: ParBc; cl02129 56107012280 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 56107012281 Stage II sporulation protein; Region: SpoIID; pfam08486 56107012282 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 56107012283 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 56107012284 catalytic loop [active] 56107012285 iron binding site [ion binding]; other site 56107012286 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 56107012287 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 56107012288 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 56107012289 active site 56107012290 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107012291 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107012292 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107012293 TPR repeat; Region: TPR_11; pfam13414 56107012294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012295 binding surface 56107012296 TPR motif; other site 56107012297 TPR repeat; Region: TPR_11; pfam13414 56107012298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012299 binding surface 56107012300 TPR repeat; Region: TPR_11; pfam13414 56107012301 TPR motif; other site 56107012302 TPR repeat; Region: TPR_11; pfam13414 56107012303 TPR repeat; Region: TPR_11; pfam13414 56107012304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012305 binding surface 56107012306 TPR motif; other site 56107012307 TPR repeat; Region: TPR_11; pfam13414 56107012308 TPR repeat; Region: TPR_11; pfam13414 56107012309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012310 binding surface 56107012311 TPR motif; other site 56107012312 TPR repeat; Region: TPR_11; pfam13414 56107012313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012314 binding surface 56107012315 TPR repeat; Region: TPR_11; pfam13414 56107012316 TPR motif; other site 56107012317 TPR repeat; Region: TPR_11; pfam13414 56107012318 TPR repeat; Region: TPR_11; pfam13414 56107012319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012320 binding surface 56107012321 TPR motif; other site 56107012322 TPR repeat; Region: TPR_11; pfam13414 56107012323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012324 binding surface 56107012325 TPR motif; other site 56107012326 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 56107012327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012328 binding surface 56107012329 TPR motif; other site 56107012330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012331 binding surface 56107012332 TPR motif; other site 56107012333 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 56107012334 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 56107012335 NADP binding site [chemical binding]; other site 56107012336 active site 56107012337 putative substrate binding site [chemical binding]; other site 56107012338 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 56107012339 Uncharacterized conserved protein [Function unknown]; Region: COG4021 56107012340 Thg1 C terminal domain; Region: Thg1C; pfam14413 56107012341 AAA domain; Region: AAA_33; pfam13671 56107012342 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 56107012343 glycine dehydrogenase; Provisional; Region: PRK05367 56107012344 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 56107012345 tetramer interface [polypeptide binding]; other site 56107012346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107012347 catalytic residue [active] 56107012348 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 56107012349 tetramer interface [polypeptide binding]; other site 56107012350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107012351 catalytic residue [active] 56107012352 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 56107012353 lipoyl attachment site [posttranslational modification]; other site 56107012354 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 56107012355 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 56107012356 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 56107012357 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 56107012358 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 56107012359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107012360 Coenzyme A binding pocket [chemical binding]; other site 56107012361 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107012362 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107012363 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 56107012364 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 56107012365 NB-ARC domain; Region: NB-ARC; pfam00931 56107012366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 56107012367 binding surface 56107012368 TPR motif; other site 56107012369 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107012370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012371 binding surface 56107012372 TPR motif; other site 56107012373 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107012374 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107012375 Tetratricopeptide repeat; Region: TPR_10; pfam13374 56107012376 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107012377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012378 binding surface 56107012379 TPR motif; other site 56107012380 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107012381 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 56107012382 ligand-binding site [chemical binding]; other site 56107012383 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 56107012384 Family description; Region: VCBS; pfam13517 56107012385 Family description; Region: VCBS; pfam13517 56107012386 Family description; Region: VCBS; pfam13517 56107012387 Family description; Region: VCBS; pfam13517 56107012388 Family description; Region: VCBS; pfam13517 56107012389 Family description; Region: VCBS; pfam13517 56107012390 Family description; Region: VCBS; pfam13517 56107012391 TIGR03032 family protein; Region: TIGR03032 56107012392 TPR repeat; Region: TPR_11; pfam13414 56107012393 Tetratricopeptide repeat; Region: TPR_6; pfam13174 56107012394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012395 binding surface 56107012396 TPR motif; other site 56107012397 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 56107012398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012399 binding surface 56107012400 TPR motif; other site 56107012401 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 56107012402 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107012403 putative active site [active] 56107012404 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 56107012405 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 56107012406 substrate binding site [chemical binding]; other site 56107012407 glutamase interaction surface [polypeptide binding]; other site 56107012408 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 56107012409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107012410 Walker A motif; other site 56107012411 ATP binding site [chemical binding]; other site 56107012412 Walker B motif; other site 56107012413 arginine finger; other site 56107012414 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 56107012415 TPR repeat; Region: TPR_11; pfam13414 56107012416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012417 binding surface 56107012418 TPR motif; other site 56107012419 TPR repeat; Region: TPR_11; pfam13414 56107012420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012421 binding surface 56107012422 TPR motif; other site 56107012423 TPR repeat; Region: TPR_11; pfam13414 56107012424 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107012425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012426 binding surface 56107012427 TPR motif; other site 56107012428 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 56107012429 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 56107012430 hypothetical protein; Provisional; Region: PRK02724 56107012431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 56107012432 SPFH domain / Band 7 family; Region: Band_7; pfam01145 56107012433 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107012434 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 56107012435 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 56107012436 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 56107012437 gamma subunit interface [polypeptide binding]; other site 56107012438 epsilon subunit interface [polypeptide binding]; other site 56107012439 LBP interface [polypeptide binding]; other site 56107012440 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 56107012441 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 56107012442 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 56107012443 alpha subunit interaction interface [polypeptide binding]; other site 56107012444 Walker A motif; other site 56107012445 ATP binding site [chemical binding]; other site 56107012446 Walker B motif; other site 56107012447 inhibitor binding site; inhibition site 56107012448 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 56107012449 Uncharacterized conserved protein [Function unknown]; Region: COG2912 56107012450 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 56107012451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012452 binding surface 56107012453 TPR motif; other site 56107012454 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 56107012455 hydrophobic ligand binding site; other site 56107012456 Conserved TM helix; Region: TM_helix; pfam05552 56107012457 Conserved TM helix; Region: TM_helix; pfam05552 56107012458 Conserved TM helix; Region: TM_helix; pfam05552 56107012459 Conserved TM helix; Region: TM_helix; pfam05552 56107012460 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 56107012461 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 56107012462 G1 box; other site 56107012463 GTP/Mg2+ binding site [chemical binding]; other site 56107012464 Switch I region; other site 56107012465 G2 box; other site 56107012466 Switch II region; other site 56107012467 G3 box; other site 56107012468 G4 box; other site 56107012469 G5 box; other site 56107012470 Domain of unknown function (DUF697); Region: DUF697; pfam05128 56107012471 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107012472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107012473 S-adenosylmethionine binding site [chemical binding]; other site 56107012474 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 56107012475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107012476 S-adenosylmethionine binding site [chemical binding]; other site 56107012477 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 56107012478 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 56107012479 triosephosphate isomerase; Provisional; Region: PRK14565 56107012480 dimer interface [polypeptide binding]; other site 56107012481 substrate binding site [chemical binding]; other site 56107012482 catalytic triad [active] 56107012483 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 56107012484 dihydropteroate synthase; Region: DHPS; TIGR01496 56107012485 substrate binding pocket [chemical binding]; other site 56107012486 dimer interface [polypeptide binding]; other site 56107012487 inhibitor binding site; inhibition site 56107012488 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 56107012489 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 56107012490 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 56107012491 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 56107012492 SLBB domain; Region: SLBB; pfam10531 56107012493 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 56107012494 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 56107012495 Walker A/P-loop; other site 56107012496 ATP binding site [chemical binding]; other site 56107012497 Q-loop/lid; other site 56107012498 ABC transporter signature motif; other site 56107012499 Walker B; other site 56107012500 D-loop; other site 56107012501 H-loop/switch region; other site 56107012502 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 56107012503 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 56107012504 putative active site pocket [active] 56107012505 4-fold oligomerization interface [polypeptide binding]; other site 56107012506 metal binding residues [ion binding]; metal-binding site 56107012507 3-fold/trimer interface [polypeptide binding]; other site 56107012508 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 56107012509 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 56107012510 NAD binding site [chemical binding]; other site 56107012511 homotetramer interface [polypeptide binding]; other site 56107012512 homodimer interface [polypeptide binding]; other site 56107012513 substrate binding site [chemical binding]; other site 56107012514 active site 56107012515 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107012516 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 56107012517 ligand binding site [chemical binding]; other site 56107012518 flexible hinge region; other site 56107012519 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 56107012520 putative switch regulator; other site 56107012521 non-specific DNA interactions [nucleotide binding]; other site 56107012522 DNA binding site [nucleotide binding] 56107012523 sequence specific DNA binding site [nucleotide binding]; other site 56107012524 putative cAMP binding site [chemical binding]; other site 56107012525 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 56107012526 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 56107012527 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 56107012528 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 56107012529 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 56107012530 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 56107012531 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 56107012532 Asparagine synthase; Region: Asn_synthase; pfam00733 56107012533 Asparagine synthase; Region: Asn_synthase; pfam00733 56107012534 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 56107012535 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 56107012536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107012537 Walker A/P-loop; other site 56107012538 ATP binding site [chemical binding]; other site 56107012539 Q-loop/lid; other site 56107012540 ABC transporter signature motif; other site 56107012541 Walker B; other site 56107012542 D-loop; other site 56107012543 H-loop/switch region; other site 56107012544 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 56107012545 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 56107012546 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107012547 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 56107012548 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 56107012549 FtsX-like permease family; Region: FtsX; pfam02687 56107012550 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 56107012551 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 56107012552 RNase E interface [polypeptide binding]; other site 56107012553 trimer interface [polypeptide binding]; other site 56107012554 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 56107012555 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 56107012556 RNase E interface [polypeptide binding]; other site 56107012557 trimer interface [polypeptide binding]; other site 56107012558 active site 56107012559 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 56107012560 putative nucleic acid binding region [nucleotide binding]; other site 56107012561 G-X-X-G motif; other site 56107012562 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 56107012563 RNA binding site [nucleotide binding]; other site 56107012564 domain interface; other site 56107012565 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 56107012566 SNF2 Helicase protein; Region: DUF3670; pfam12419 56107012567 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107012568 ATP binding site [chemical binding]; other site 56107012569 putative Mg++ binding site [ion binding]; other site 56107012570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107012571 nucleotide binding region [chemical binding]; other site 56107012572 ATP-binding site [chemical binding]; other site 56107012573 Uncharacterized conserved protein [Function unknown]; Region: COG4279 56107012574 SWIM zinc finger; Region: SWIM; pfam04434 56107012575 Protein of unknown function (DUF433); Region: DUF433; pfam04255 56107012576 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107012577 putative active site [active] 56107012578 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 56107012579 photosystem II 44 kDa protein; Region: psbC; CHL00035 56107012580 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 56107012581 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 56107012582 D1 interface; other site 56107012583 chlorophyll binding site; other site 56107012584 pheophytin binding site; other site 56107012585 beta carotene binding site; other site 56107012586 cytochrome b559 beta interface; other site 56107012587 quinone binding site; other site 56107012588 cytochrome b559 alpha interface; other site 56107012589 protein J interface; other site 56107012590 protein H interface; other site 56107012591 protein X interface; other site 56107012592 core light harvesting protein interface; other site 56107012593 protein L interface; other site 56107012594 CP43 interface; other site 56107012595 protein T interface; other site 56107012596 Fe binding site [ion binding]; other site 56107012597 protein M interface; other site 56107012598 Mn-stabilizing polypeptide interface; other site 56107012599 bromide binding site; other site 56107012600 cytochrome c-550 interface; other site 56107012601 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 56107012602 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 56107012603 active site 56107012604 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 56107012605 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 56107012606 dimer interface [polypeptide binding]; other site 56107012607 active site 56107012608 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 56107012609 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 56107012610 CHASE2 domain; Region: CHASE2; pfam05226 56107012611 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 56107012612 cyclase homology domain; Region: CHD; cd07302 56107012613 nucleotidyl binding site; other site 56107012614 metal binding site [ion binding]; metal-binding site 56107012615 dimer interface [polypeptide binding]; other site 56107012616 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 56107012617 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107012618 Bacterial SH3 domain; Region: SH3_3; pfam08239 56107012619 KWG Leptospira; Region: KWG; pfam07656 56107012620 KWG Leptospira; Region: KWG; pfam07656 56107012621 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107012622 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 56107012623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107012624 Walker A motif; other site 56107012625 ATP binding site [chemical binding]; other site 56107012626 Walker B motif; other site 56107012627 arginine finger; other site 56107012628 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 56107012629 substrate binding pocket [chemical binding]; other site 56107012630 substrate-Mg2+ binding site; other site 56107012631 aspartate-rich region 1; other site 56107012632 aspartate-rich region 2; other site 56107012633 KWG Leptospira; Region: KWG; pfam07656 56107012634 KWG Leptospira; Region: KWG; pfam07656 56107012635 KWG Leptospira; Region: KWG; pfam07656 56107012636 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107012637 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107012638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107012639 Major Facilitator Superfamily; Region: MFS_1; pfam07690 56107012640 putative substrate translocation pore; other site 56107012641 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 56107012642 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 56107012643 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 56107012644 NAD(P) binding site [chemical binding]; other site 56107012645 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 56107012646 PemK-like protein; Region: PemK; pfam02452 56107012647 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 56107012648 Methyltransferase domain; Region: Methyltransf_25; pfam13649 56107012649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 56107012650 septum formation inhibitor; Reviewed; Region: minC; PRK00513 56107012651 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 56107012652 septum site-determining protein MinD; Region: minD_bact; TIGR01968 56107012653 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 56107012654 Switch I; other site 56107012655 Switch II; other site 56107012656 cell division topological specificity factor MinE; Provisional; Region: PRK13988 56107012657 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107012658 putative active site [active] 56107012659 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 56107012660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107012661 non-specific DNA binding site [nucleotide binding]; other site 56107012662 salt bridge; other site 56107012663 sequence-specific DNA binding site [nucleotide binding]; other site 56107012664 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107012665 putative active site [active] 56107012666 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107012667 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107012668 putative active site [active] 56107012669 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 56107012670 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 56107012671 putative active site [active] 56107012672 substrate binding site [chemical binding]; other site 56107012673 putative cosubstrate binding site; other site 56107012674 catalytic site [active] 56107012675 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 56107012676 substrate binding site [chemical binding]; other site 56107012677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012678 binding surface 56107012679 TPR motif; other site 56107012680 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107012681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012682 binding surface 56107012683 TPR motif; other site 56107012684 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107012685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012686 binding surface 56107012687 TPR motif; other site 56107012688 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107012689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012690 binding surface 56107012691 TPR motif; other site 56107012692 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107012693 photosystem I subunit VII; Region: psaC; CHL00065 56107012694 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 56107012695 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 56107012696 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 56107012697 glutaminase active site [active] 56107012698 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 56107012699 dimer interface [polypeptide binding]; other site 56107012700 active site 56107012701 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 56107012702 dimer interface [polypeptide binding]; other site 56107012703 active site 56107012704 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 56107012705 DNA protecting protein DprA; Region: dprA; TIGR00732 56107012706 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 56107012707 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 56107012708 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 56107012709 classical (c) SDRs; Region: SDR_c; cd05233 56107012710 NAD(P) binding site [chemical binding]; other site 56107012711 active site 56107012712 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 56107012713 active site 56107012714 catalytic site [active] 56107012715 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 56107012716 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 56107012717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107012718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107012719 ATP binding site [chemical binding]; other site 56107012720 Mg2+ binding site [ion binding]; other site 56107012721 G-X-G motif; other site 56107012722 Predicted permeases [General function prediction only]; Region: COG0701 56107012723 TIGR03943 family protein; Region: TIGR03943 56107012724 Bacterial Ig-like domain; Region: Big_5; pfam13205 56107012725 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 56107012726 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 56107012727 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 56107012728 active site 56107012729 catalytic residues [active] 56107012730 metal binding site [ion binding]; metal-binding site 56107012731 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 56107012732 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 56107012733 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 56107012734 catalytic loop [active] 56107012735 iron binding site [ion binding]; other site 56107012736 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 56107012737 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 56107012738 ThiS interaction site; other site 56107012739 putative active site [active] 56107012740 tetramer interface [polypeptide binding]; other site 56107012741 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 56107012742 AAA domain; Region: AAA_21; pfam13304 56107012743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012744 binding surface 56107012745 TPR motif; other site 56107012746 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107012747 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107012748 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 56107012749 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 56107012750 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 56107012751 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 56107012752 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107012753 Methyltransferase domain; Region: Methyltransf_26; pfam13659 56107012754 Sulfate transporter family; Region: Sulfate_transp; pfam00916 56107012755 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 56107012756 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 56107012757 Uncharacterized conserved protein [Function unknown]; Region: COG1565 56107012758 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 56107012759 Rubredoxin; Region: Rubredoxin; pfam00301 56107012760 iron binding site [ion binding]; other site 56107012761 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 56107012762 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 56107012763 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107012764 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107012765 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 56107012766 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 56107012767 MraW methylase family; Region: Methyltransf_5; cl17771 56107012768 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 56107012769 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107012770 putative active site [active] 56107012771 Predicted transcriptional regulators [Transcription]; Region: COG1695 56107012772 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 56107012773 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 56107012774 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107012775 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 56107012776 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 56107012777 Walker A/P-loop; other site 56107012778 ATP binding site [chemical binding]; other site 56107012779 Q-loop/lid; other site 56107012780 ABC transporter signature motif; other site 56107012781 Walker B; other site 56107012782 D-loop; other site 56107012783 H-loop/switch region; other site 56107012784 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 56107012785 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 56107012786 Walker A/P-loop; other site 56107012787 ATP binding site [chemical binding]; other site 56107012788 Q-loop/lid; other site 56107012789 ABC transporter signature motif; other site 56107012790 Walker B; other site 56107012791 D-loop; other site 56107012792 H-loop/switch region; other site 56107012793 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 56107012794 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 56107012795 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 56107012796 dimer interface [polypeptide binding]; other site 56107012797 ssDNA binding site [nucleotide binding]; other site 56107012798 tetramer (dimer of dimers) interface [polypeptide binding]; other site 56107012799 hypothetical protein; Provisional; Region: PRK06185 56107012800 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 56107012801 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 56107012802 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 56107012803 Walker A/P-loop; other site 56107012804 ATP binding site [chemical binding]; other site 56107012805 Q-loop/lid; other site 56107012806 ABC transporter signature motif; other site 56107012807 Walker B; other site 56107012808 D-loop; other site 56107012809 H-loop/switch region; other site 56107012810 TOBE domain; Region: TOBE_2; pfam08402 56107012811 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107012812 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107012813 active site 56107012814 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 56107012815 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107012816 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 56107012817 Ligand binding site; other site 56107012818 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 56107012819 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 56107012820 active site 56107012821 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107012822 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107012823 active site 56107012824 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 56107012825 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 56107012826 Chain length determinant protein; Region: Wzz; pfam02706 56107012827 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 56107012828 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107012829 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 56107012830 Bacterial sugar transferase; Region: Bac_transf; pfam02397 56107012831 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 56107012832 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 56107012833 NAD binding site [chemical binding]; other site 56107012834 homodimer interface [polypeptide binding]; other site 56107012835 active site 56107012836 substrate binding site [chemical binding]; other site 56107012837 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107012838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107012839 active site 56107012840 phosphorylation site [posttranslational modification] 56107012841 intermolecular recognition site; other site 56107012842 dimerization interface [polypeptide binding]; other site 56107012843 Protein kinase domain; Region: Pkinase; pfam00069 56107012844 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107012845 active site 56107012846 ATP binding site [chemical binding]; other site 56107012847 substrate binding site [chemical binding]; other site 56107012848 activation loop (A-loop); other site 56107012849 AAA ATPase domain; Region: AAA_16; pfam13191 56107012850 Predicted ATPase [General function prediction only]; Region: COG3899 56107012851 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107012852 GAF domain; Region: GAF; pfam01590 56107012853 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107012854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107012855 dimer interface [polypeptide binding]; other site 56107012856 phosphorylation site [posttranslational modification] 56107012857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107012858 ATP binding site [chemical binding]; other site 56107012859 Mg2+ binding site [ion binding]; other site 56107012860 G-X-G motif; other site 56107012861 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107012862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107012863 active site 56107012864 phosphorylation site [posttranslational modification] 56107012865 intermolecular recognition site; other site 56107012866 dimerization interface [polypeptide binding]; other site 56107012867 PAS domain S-box; Region: sensory_box; TIGR00229 56107012868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107012869 putative active site [active] 56107012870 heme pocket [chemical binding]; other site 56107012871 PAS fold; Region: PAS_3; pfam08447 56107012872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107012873 putative active site [active] 56107012874 heme pocket [chemical binding]; other site 56107012875 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107012876 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107012877 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107012878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107012879 dimer interface [polypeptide binding]; other site 56107012880 phosphorylation site [posttranslational modification] 56107012881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107012882 ATP binding site [chemical binding]; other site 56107012883 Mg2+ binding site [ion binding]; other site 56107012884 G-X-G motif; other site 56107012885 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107012886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107012887 active site 56107012888 phosphorylation site [posttranslational modification] 56107012889 intermolecular recognition site; other site 56107012890 dimerization interface [polypeptide binding]; other site 56107012891 GxxExxY protein; Region: GxxExxY; TIGR04256 56107012892 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 56107012893 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 56107012894 active site 56107012895 Substrate binding site; other site 56107012896 Mg++ binding site; other site 56107012897 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 56107012898 putative trimer interface [polypeptide binding]; other site 56107012899 putative CoA binding site [chemical binding]; other site 56107012900 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 56107012901 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 56107012902 YciI-like protein; Reviewed; Region: PRK12864 56107012903 Uncharacterized conserved protein [Function unknown]; Region: COG2442 56107012904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 56107012905 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 56107012906 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 56107012907 putative tRNA-binding site [nucleotide binding]; other site 56107012908 B3/4 domain; Region: B3_4; pfam03483 56107012909 tRNA synthetase B5 domain; Region: B5; smart00874 56107012910 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 56107012911 dimer interface [polypeptide binding]; other site 56107012912 motif 1; other site 56107012913 motif 3; other site 56107012914 motif 2; other site 56107012915 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 56107012916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107012917 Coenzyme A binding pocket [chemical binding]; other site 56107012918 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107012919 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 56107012920 Response regulator receiver domain; Region: Response_reg; pfam00072 56107012921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107012922 active site 56107012923 phosphorylation site [posttranslational modification] 56107012924 intermolecular recognition site; other site 56107012925 dimerization interface [polypeptide binding]; other site 56107012926 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 56107012927 metal ion-dependent adhesion site (MIDAS); other site 56107012928 Protein phosphatase 2C; Region: PP2C_2; pfam13672 56107012929 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 56107012930 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 56107012931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012932 binding surface 56107012933 TPR repeat; Region: TPR_11; pfam13414 56107012934 TPR motif; other site 56107012935 TPR repeat; Region: TPR_11; pfam13414 56107012936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012937 binding surface 56107012938 TPR motif; other site 56107012939 TPR repeat; Region: TPR_11; pfam13414 56107012940 TPR repeat; Region: TPR_11; pfam13414 56107012941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107012942 binding surface 56107012943 TPR motif; other site 56107012944 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 56107012945 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 56107012946 substrate binding site; other site 56107012947 Predicted dehydrogenase [General function prediction only]; Region: COG0579 56107012948 hydroxyglutarate oxidase; Provisional; Region: PRK11728 56107012949 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 56107012950 extended (e) SDRs; Region: SDR_e; cd08946 56107012951 NAD(P) binding site [chemical binding]; other site 56107012952 active site 56107012953 substrate binding site [chemical binding]; other site 56107012954 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107012955 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 56107012956 active site 56107012957 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 56107012958 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 56107012959 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 56107012960 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 56107012961 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 56107012962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107012963 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107012964 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 56107012965 putative ADP-binding pocket [chemical binding]; other site 56107012966 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 56107012967 Chain length determinant protein; Region: Wzz; pfam02706 56107012968 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 56107012969 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 56107012970 Bacterial sugar transferase; Region: Bac_transf; cl00939 56107012971 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107012972 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 56107012973 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 56107012974 Walker A/P-loop; other site 56107012975 ATP binding site [chemical binding]; other site 56107012976 Q-loop/lid; other site 56107012977 ABC transporter signature motif; other site 56107012978 Walker B; other site 56107012979 D-loop; other site 56107012980 H-loop/switch region; other site 56107012981 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 56107012982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107012983 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107012984 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107012985 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 56107012986 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107012987 putative ADP-binding pocket [chemical binding]; other site 56107012988 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107012989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107012990 active site 56107012991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107012992 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107012993 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107012994 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107012995 active site 56107012996 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 56107012997 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 56107012998 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 56107012999 active site 56107013000 Zn binding site [ion binding]; other site 56107013001 Uncharacterized conserved protein [Function unknown]; Region: COG3391 56107013002 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107013003 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107013004 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107013005 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107013006 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 56107013007 Mechanosensitive ion channel; Region: MS_channel; pfam00924 56107013008 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 56107013009 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 56107013010 homotetramer interface [polypeptide binding]; other site 56107013011 ligand binding site [chemical binding]; other site 56107013012 catalytic site [active] 56107013013 NAD binding site [chemical binding]; other site 56107013014 Restriction endonuclease; Region: Mrr_cat; pfam04471 56107013015 XisH protein; Region: XisH; pfam08814 56107013016 XisI protein; Region: XisI; pfam08869 56107013017 Protein kinase domain; Region: Pkinase; pfam00069 56107013018 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107013019 active site 56107013020 ATP binding site [chemical binding]; other site 56107013021 substrate binding site [chemical binding]; other site 56107013022 activation loop (A-loop); other site 56107013023 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107013024 GAF domain; Region: GAF; pfam01590 56107013025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107013026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107013027 dimer interface [polypeptide binding]; other site 56107013028 phosphorylation site [posttranslational modification] 56107013029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107013030 ATP binding site [chemical binding]; other site 56107013031 Mg2+ binding site [ion binding]; other site 56107013032 G-X-G motif; other site 56107013033 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 56107013034 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107013035 HSP70 interaction site [polypeptide binding]; other site 56107013036 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107013037 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107013038 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107013039 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 56107013040 catalytic residues [active] 56107013041 dimer interface [polypeptide binding]; other site 56107013042 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 56107013043 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 56107013044 putative NAD(P) binding site [chemical binding]; other site 56107013045 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 56107013046 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 56107013047 catalytic triad [active] 56107013048 dimer interface [polypeptide binding]; other site 56107013049 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 56107013050 GSH binding site [chemical binding]; other site 56107013051 catalytic residues [active] 56107013052 urease subunit alpha; Reviewed; Region: ureC; PRK13207 56107013053 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 56107013054 subunit interactions [polypeptide binding]; other site 56107013055 active site 56107013056 flap region; other site 56107013057 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 56107013058 UreF; Region: UreF; pfam01730 56107013059 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 56107013060 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 56107013061 dimer interface [polypeptide binding]; other site 56107013062 catalytic residues [active] 56107013063 UreD urease accessory protein; Region: UreD; pfam01774 56107013064 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107013065 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 56107013066 gamma-beta subunit interface [polypeptide binding]; other site 56107013067 alpha-beta subunit interface [polypeptide binding]; other site 56107013068 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 56107013069 alpha-gamma subunit interface [polypeptide binding]; other site 56107013070 beta-gamma subunit interface [polypeptide binding]; other site 56107013071 Domain of unknown function (DUF897); Region: DUF897; pfam05982 56107013072 Nitrogen regulatory protein P-II; Region: P-II; cl00412 56107013073 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 56107013074 oligomeric interface; other site 56107013075 putative active site [active] 56107013076 homodimer interface [polypeptide binding]; other site 56107013077 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 56107013078 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 56107013079 dimer interface [polypeptide binding]; other site 56107013080 active site 56107013081 metal binding site [ion binding]; metal-binding site 56107013082 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 56107013083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 56107013084 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 56107013085 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 56107013086 active site 56107013087 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 56107013088 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 56107013089 C-terminal domain interface [polypeptide binding]; other site 56107013090 GSH binding site (G-site) [chemical binding]; other site 56107013091 dimer interface [polypeptide binding]; other site 56107013092 dimer interface [polypeptide binding]; other site 56107013093 N-terminal domain interface [polypeptide binding]; other site 56107013094 substrate binding pocket (H-site) [chemical binding]; other site 56107013095 Glutathione S-transferase, C-terminal domain; Region: GST_C; pfam00043 56107013096 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 56107013097 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 56107013098 Glucose inhibited division protein A; Region: GIDA; pfam01134 56107013099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 56107013100 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 56107013101 Peptidase family M23; Region: Peptidase_M23; pfam01551 56107013102 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107013103 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107013104 ligand binding site [chemical binding]; other site 56107013105 flexible hinge region; other site 56107013106 NB-ARC domain; Region: NB-ARC; pfam00931 56107013107 Tetratricopeptide repeat; Region: TPR_10; cl17452 56107013108 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107013109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107013110 binding surface 56107013111 TPR motif; other site 56107013112 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107013113 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107013114 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107013115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107013116 binding surface 56107013117 TPR motif; other site 56107013118 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107013119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107013120 TPR motif; other site 56107013121 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107013122 binding surface 56107013123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107013124 binding surface 56107013125 TPR motif; other site 56107013126 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107013127 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107013128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107013129 S-adenosylmethionine binding site [chemical binding]; other site 56107013130 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 56107013131 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 56107013132 active site 56107013133 Uncharacterized conserved protein [Function unknown]; Region: COG3349 56107013134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107013135 Uncharacterized conserved protein [Function unknown]; Region: COG1801 56107013136 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 56107013137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107013138 dimer interface [polypeptide binding]; other site 56107013139 conserved gate region; other site 56107013140 putative PBP binding loops; other site 56107013141 ABC-ATPase subunit interface; other site 56107013142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107013143 Walker A/P-loop; other site 56107013144 ATP binding site [chemical binding]; other site 56107013145 ABC transporter; Region: ABC_tran; pfam00005 56107013146 Q-loop/lid; other site 56107013147 ABC transporter signature motif; other site 56107013148 Walker B; other site 56107013149 D-loop; other site 56107013150 H-loop/switch region; other site 56107013151 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 56107013152 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 56107013153 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 56107013154 Domain of unknown function (DUF427); Region: DUF427; cl00998 56107013155 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 56107013156 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107013157 ATP binding site [chemical binding]; other site 56107013158 putative Mg++ binding site [ion binding]; other site 56107013159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107013160 nucleotide binding region [chemical binding]; other site 56107013161 ATP-binding site [chemical binding]; other site 56107013162 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 56107013163 HRDC domain; Region: HRDC; pfam00570 56107013164 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 56107013165 DNA binding residues [nucleotide binding] 56107013166 Caspase domain; Region: Peptidase_C14; pfam00656 56107013167 AAA ATPase domain; Region: AAA_16; pfam13191 56107013168 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107013169 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107013170 short chain dehydrogenase; Provisional; Region: PRK06172 56107013171 classical (c) SDRs; Region: SDR_c; cd05233 56107013172 NAD(P) binding site [chemical binding]; other site 56107013173 active site 56107013174 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 56107013175 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 56107013176 acyl-activating enzyme (AAE) consensus motif; other site 56107013177 putative AMP binding site [chemical binding]; other site 56107013178 putative active site [active] 56107013179 putative CoA binding site [chemical binding]; other site 56107013180 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 56107013181 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 56107013182 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 56107013183 E3 interaction surface; other site 56107013184 lipoyl attachment site [posttranslational modification]; other site 56107013185 e3 binding domain; Region: E3_binding; pfam02817 56107013186 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 56107013187 CHASE2 domain; Region: CHASE2; pfam05226 56107013188 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 56107013189 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 56107013190 cyclase homology domain; Region: CHD; cd07302 56107013191 nucleotidyl binding site; other site 56107013192 metal binding site [ion binding]; metal-binding site 56107013193 dimer interface [polypeptide binding]; other site 56107013194 FecR protein; Region: FecR; pfam04773 56107013195 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 56107013196 hypothetical protein; Reviewed; Region: PRK09588 56107013197 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 56107013198 NMT1-like family; Region: NMT1_2; pfam13379 56107013199 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 56107013200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107013201 dimer interface [polypeptide binding]; other site 56107013202 conserved gate region; other site 56107013203 putative PBP binding loops; other site 56107013204 ABC-ATPase subunit interface; other site 56107013205 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 56107013206 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 56107013207 Walker A/P-loop; other site 56107013208 ATP binding site [chemical binding]; other site 56107013209 Q-loop/lid; other site 56107013210 ABC transporter signature motif; other site 56107013211 Walker B; other site 56107013212 D-loop; other site 56107013213 H-loop/switch region; other site 56107013214 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 56107013215 NMT1-like family; Region: NMT1_2; pfam13379 56107013216 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 56107013217 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 56107013218 Walker A/P-loop; other site 56107013219 ATP binding site [chemical binding]; other site 56107013220 Q-loop/lid; other site 56107013221 ABC transporter signature motif; other site 56107013222 Walker B; other site 56107013223 D-loop; other site 56107013224 H-loop/switch region; other site 56107013225 Methyltransferase domain; Region: Methyltransf_23; pfam13489 56107013226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107013227 S-adenosylmethionine binding site [chemical binding]; other site 56107013228 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 56107013229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107013230 motif II; other site 56107013231 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 56107013232 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 56107013233 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107013234 ATP binding site [chemical binding]; other site 56107013235 putative Mg++ binding site [ion binding]; other site 56107013236 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 56107013237 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107013238 putative active site [active] 56107013239 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 56107013240 oligomeric interface; other site 56107013241 putative active site [active] 56107013242 homodimer interface [polypeptide binding]; other site 56107013243 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 56107013244 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 56107013245 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 56107013246 maltose O-acetyltransferase; Provisional; Region: PRK10092 56107013247 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 56107013248 active site 56107013249 substrate binding site [chemical binding]; other site 56107013250 trimer interface [polypeptide binding]; other site 56107013251 CoA binding site [chemical binding]; other site 56107013252 Calcium binding; Region: Calci_bind_CcbP; pfam11535 56107013253 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 56107013254 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 56107013255 substrate binding site [chemical binding]; other site 56107013256 dimer interface [polypeptide binding]; other site 56107013257 ATP binding site [chemical binding]; other site 56107013258 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 56107013259 nucleoside/Zn binding site; other site 56107013260 dimer interface [polypeptide binding]; other site 56107013261 catalytic motif [active] 56107013262 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 56107013263 active site 56107013264 dimerization interface [polypeptide binding]; other site 56107013265 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 56107013266 dimer interface [polypeptide binding]; other site 56107013267 ADP-ribose binding site [chemical binding]; other site 56107013268 active site 56107013269 nudix motif; other site 56107013270 metal binding site [ion binding]; metal-binding site 56107013271 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 56107013272 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 56107013273 active site 56107013274 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 56107013275 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 56107013276 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 56107013277 Peptidase family M48; Region: Peptidase_M48; cl12018 56107013278 Circadian oscillating protein COP23; Region: COP23; pfam14218 56107013279 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 56107013280 generic binding surface II; other site 56107013281 generic binding surface I; other site 56107013282 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 56107013283 putative catalytic site [active] 56107013284 putative metal binding site [ion binding]; other site 56107013285 putative phosphate binding site [ion binding]; other site 56107013286 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 56107013287 Ca2+ binding site [ion binding]; other site 56107013288 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 56107013289 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 56107013290 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 56107013291 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107013292 ligand binding site [chemical binding]; other site 56107013293 flexible hinge region; other site 56107013294 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 56107013295 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 56107013296 putative active site [active] 56107013297 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107013298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107013299 Walker A/P-loop; other site 56107013300 ATP binding site [chemical binding]; other site 56107013301 Q-loop/lid; other site 56107013302 ABC transporter signature motif; other site 56107013303 Walker B; other site 56107013304 D-loop; other site 56107013305 H-loop/switch region; other site 56107013306 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 56107013307 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 56107013308 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107013309 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 56107013310 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 56107013311 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 56107013312 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 56107013313 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 56107013314 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 56107013315 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 56107013316 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 56107013317 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 56107013318 intersubunit interface [polypeptide binding]; other site 56107013319 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107013320 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107013321 structural tetrad; other site 56107013322 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 56107013323 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 56107013324 P-loop, Walker A motif; other site 56107013325 Base recognition motif; other site 56107013326 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 56107013327 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 56107013328 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 56107013329 photosystem I reaction center subunit X; Reviewed; Region: PRK13214 56107013330 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 56107013331 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 56107013332 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 56107013333 active site 56107013334 metal binding site [ion binding]; metal-binding site 56107013335 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 56107013336 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107013337 putative active site [active] 56107013338 dihydrodipicolinate reductase; Provisional; Region: PRK00048 56107013339 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 56107013340 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 56107013341 precorrin-8X methylmutase; Validated; Region: PRK05953 56107013342 Precorrin-8X methylmutase; Region: CbiC; pfam02570 56107013343 Repair protein; Region: Repair_PSII; pfam04536 56107013344 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 56107013345 Competence protein CoiA-like family; Region: CoiA; cl11541 56107013346 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 56107013347 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 56107013348 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107013349 active site 56107013350 catalytic residues [active] 56107013351 DNA binding site [nucleotide binding] 56107013352 Int/Topo IB signature motif; other site 56107013353 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 56107013354 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 56107013355 ABC-ATPase subunit interface; other site 56107013356 dimer interface [polypeptide binding]; other site 56107013357 putative PBP binding regions; other site 56107013358 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 56107013359 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 56107013360 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 56107013361 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 56107013362 metal binding site [ion binding]; metal-binding site 56107013363 S-layer homology domain; Region: SLH; pfam00395 56107013364 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 56107013365 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 56107013366 Domain of unknown function (DUF814); Region: DUF814; pfam05670 56107013367 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 56107013368 RNA recognition motif; Region: RRM; smart00360 56107013369 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 56107013370 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 56107013371 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 56107013372 G1 box; other site 56107013373 putative GEF interaction site [polypeptide binding]; other site 56107013374 GTP/Mg2+ binding site [chemical binding]; other site 56107013375 Switch I region; other site 56107013376 G2 box; other site 56107013377 G3 box; other site 56107013378 Switch II region; other site 56107013379 G4 box; other site 56107013380 G5 box; other site 56107013381 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 56107013382 Tic20-like protein; Region: Tic20; pfam09685 56107013383 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 56107013384 dimer interface [polypeptide binding]; other site 56107013385 active site 56107013386 Schiff base residues; other site 56107013387 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 56107013388 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 56107013389 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 56107013390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107013391 non-specific DNA binding site [nucleotide binding]; other site 56107013392 salt bridge; other site 56107013393 sequence-specific DNA binding site [nucleotide binding]; other site 56107013394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107013395 non-specific DNA binding site [nucleotide binding]; other site 56107013396 salt bridge; other site 56107013397 sequence-specific DNA binding site [nucleotide binding]; other site 56107013398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107013399 salt bridge; other site 56107013400 non-specific DNA binding site [nucleotide binding]; other site 56107013401 sequence-specific DNA binding site [nucleotide binding]; other site 56107013402 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 56107013403 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 56107013404 alpha subunit interface [polypeptide binding]; other site 56107013405 TPP binding site [chemical binding]; other site 56107013406 heterodimer interface [polypeptide binding]; other site 56107013407 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 56107013408 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 56107013409 protein-export membrane protein SecD; Region: secD; TIGR01129 56107013410 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 56107013411 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 56107013412 Protein export membrane protein; Region: SecD_SecF; pfam02355 56107013413 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 56107013414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107013415 Coenzyme A binding pocket [chemical binding]; other site 56107013416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107013417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107013418 dimer interface [polypeptide binding]; other site 56107013419 phosphorylation site [posttranslational modification] 56107013420 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 56107013421 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 56107013422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107013423 S-adenosylmethionine binding site [chemical binding]; other site 56107013424 Tic22-like family; Region: Tic22; cl04468 56107013425 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 56107013426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107013427 Coenzyme A binding pocket [chemical binding]; other site 56107013428 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 56107013429 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 56107013430 catalytic site [active] 56107013431 UGMP family protein; Validated; Region: PRK09604 56107013432 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 56107013433 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 56107013434 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 56107013435 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 56107013436 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 56107013437 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 56107013438 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 56107013439 putative active site [active] 56107013440 putative NTP binding site [chemical binding]; other site 56107013441 putative nucleic acid binding site [nucleotide binding]; other site 56107013442 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 56107013443 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107013444 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107013445 active site 56107013446 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 56107013447 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 56107013448 catalytic site [active] 56107013449 G-X2-G-X-G-K; other site 56107013450 hypothetical protein; Provisional; Region: PRK04323 56107013451 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 56107013452 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 56107013453 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 56107013454 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 56107013455 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 56107013456 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 56107013457 substrate binding pocket [chemical binding]; other site 56107013458 chain length determination region; other site 56107013459 substrate-Mg2+ binding site; other site 56107013460 catalytic residues [active] 56107013461 aspartate-rich region 1; other site 56107013462 active site lid residues [active] 56107013463 aspartate-rich region 2; other site 56107013464 glutamate racemase; Provisional; Region: PRK00865 56107013465 AMIN domain; Region: AMIN; pfam11741 56107013466 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 56107013467 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 56107013468 active site 56107013469 metal binding site [ion binding]; metal-binding site 56107013470 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 56107013471 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 56107013472 EVE domain; Region: EVE; pfam01878 56107013473 Uncharacterized conserved protein [Function unknown]; Region: COG2968 56107013474 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 56107013475 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 56107013476 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 56107013477 dimer interface [polypeptide binding]; other site 56107013478 ssDNA binding site [nucleotide binding]; other site 56107013479 tetramer (dimer of dimers) interface [polypeptide binding]; other site 56107013480 rod shape-determining protein MreB; Provisional; Region: PRK13927 56107013481 MreB and similar proteins; Region: MreB_like; cd10225 56107013482 nucleotide binding site [chemical binding]; other site 56107013483 Mg binding site [ion binding]; other site 56107013484 putative protofilament interaction site [polypeptide binding]; other site 56107013485 RodZ interaction site [polypeptide binding]; other site 56107013486 rod shape-determining protein MreC; Provisional; Region: PRK13922 56107013487 rod shape-determining protein MreC; Region: MreC; pfam04085 56107013488 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 56107013489 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 56107013490 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 56107013491 catalytic motif [active] 56107013492 Zn binding site [ion binding]; other site 56107013493 RibD C-terminal domain; Region: RibD_C; cl17279 56107013494 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 56107013495 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 56107013496 homooctamer interface [polypeptide binding]; other site 56107013497 active site 56107013498 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 56107013499 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 56107013500 dimer interface [polypeptide binding]; other site 56107013501 tetramer interface [polypeptide binding]; other site 56107013502 PYR/PP interface [polypeptide binding]; other site 56107013503 TPP binding site [chemical binding]; other site 56107013504 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 56107013505 TPP-binding site; other site 56107013506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107013507 non-specific DNA binding site [nucleotide binding]; other site 56107013508 salt bridge; other site 56107013509 sequence-specific DNA binding site [nucleotide binding]; other site 56107013510 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107013511 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 56107013512 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 56107013513 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 56107013514 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 56107013515 substrate binding site [chemical binding]; other site 56107013516 oxyanion hole (OAH) forming residues; other site 56107013517 trimer interface [polypeptide binding]; other site 56107013518 Protein of unknown function (DUF721); Region: DUF721; cl02324 56107013519 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 56107013520 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 56107013521 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 56107013522 catalytic residues [active] 56107013523 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 56107013524 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 56107013525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107013526 homodimer interface [polypeptide binding]; other site 56107013527 catalytic residue [active] 56107013528 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107013529 putative active site [active] 56107013530 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 56107013531 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 56107013532 GIY-YIG motif/motif A; other site 56107013533 active site 56107013534 catalytic site [active] 56107013535 putative DNA binding site [nucleotide binding]; other site 56107013536 metal binding site [ion binding]; metal-binding site 56107013537 UvrB/uvrC motif; Region: UVR; pfam02151 56107013538 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 56107013539 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 56107013540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107013541 FeS/SAM binding site; other site 56107013542 Heme NO binding associated; Region: HNOBA; pfam07701 56107013543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107013544 dimer interface [polypeptide binding]; other site 56107013545 phosphorylation site [posttranslational modification] 56107013546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107013547 ATP binding site [chemical binding]; other site 56107013548 Mg2+ binding site [ion binding]; other site 56107013549 G-X-G motif; other site 56107013550 Heme NO binding; Region: HNOB; pfam07700 56107013551 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 56107013552 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 56107013553 PAS domain; Region: PAS; smart00091 56107013554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107013555 dimer interface [polypeptide binding]; other site 56107013556 phosphorylation site [posttranslational modification] 56107013557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107013558 ATP binding site [chemical binding]; other site 56107013559 Mg2+ binding site [ion binding]; other site 56107013560 G-X-G motif; other site 56107013561 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 56107013562 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 56107013563 active site 56107013564 SAM binding site [chemical binding]; other site 56107013565 homodimer interface [polypeptide binding]; other site 56107013566 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 56107013567 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 56107013568 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 56107013569 active site 56107013570 (T/H)XGH motif; other site 56107013571 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 56107013572 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107013573 putative active site [active] 56107013574 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 56107013575 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 56107013576 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 56107013577 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 56107013578 active site 56107013579 HIGH motif; other site 56107013580 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 56107013581 KMSKS motif; other site 56107013582 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 56107013583 tRNA binding surface [nucleotide binding]; other site 56107013584 anticodon binding site; other site 56107013585 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 56107013586 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107013587 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 56107013588 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 56107013589 putative active site [active] 56107013590 dimerization interface [polypeptide binding]; other site 56107013591 putative tRNAtyr binding site [nucleotide binding]; other site 56107013592 Psb28 protein; Region: Psb28; cl04326 56107013593 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 56107013594 MPT binding site; other site 56107013595 trimer interface [polypeptide binding]; other site 56107013596 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 56107013597 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 56107013598 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 56107013599 Mg++ binding site [ion binding]; other site 56107013600 putative catalytic motif [active] 56107013601 putative substrate binding site [chemical binding]; other site 56107013602 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 56107013603 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 56107013604 photosystem I subunit IV; Reviewed; Region: psaE; CHL00125 56107013605 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 56107013606 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 56107013607 DNA binding site [nucleotide binding] 56107013608 catalytic residue [active] 56107013609 H2TH interface [polypeptide binding]; other site 56107013610 putative catalytic residues [active] 56107013611 turnover-facilitating residue; other site 56107013612 intercalation triad [nucleotide binding]; other site 56107013613 8OG recognition residue [nucleotide binding]; other site 56107013614 putative reading head residues; other site 56107013615 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 56107013616 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 56107013617 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 56107013618 malate dehydrogenase; Reviewed; Region: PRK06223 56107013619 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 56107013620 NAD(P) binding site [chemical binding]; other site 56107013621 dimer interface [polypeptide binding]; other site 56107013622 tetramer (dimer of dimers) interface [polypeptide binding]; other site 56107013623 substrate binding site [chemical binding]; other site 56107013624 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 56107013625 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 56107013626 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 56107013627 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 56107013628 active site 56107013629 dimer interface [polypeptide binding]; other site 56107013630 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 56107013631 dimer interface [polypeptide binding]; other site 56107013632 active site 56107013633 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 56107013634 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 56107013635 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 56107013636 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 56107013637 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 56107013638 TM-ABC transporter signature motif; other site 56107013639 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 56107013640 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 56107013641 Walker A/P-loop; other site 56107013642 ATP binding site [chemical binding]; other site 56107013643 Q-loop/lid; other site 56107013644 ABC transporter signature motif; other site 56107013645 Walker B; other site 56107013646 D-loop; other site 56107013647 H-loop/switch region; other site 56107013648 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 56107013649 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 56107013650 tRNA; other site 56107013651 putative tRNA binding site [nucleotide binding]; other site 56107013652 putative NADP binding site [chemical binding]; other site 56107013653 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 56107013654 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 56107013655 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 56107013656 putative active site [active] 56107013657 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 56107013658 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 56107013659 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 56107013660 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 56107013661 GSH binding site [chemical binding]; other site 56107013662 catalytic residues [active] 56107013663 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 56107013664 nucleoside/Zn binding site; other site 56107013665 dimer interface [polypeptide binding]; other site 56107013666 catalytic motif [active] 56107013667 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 56107013668 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 56107013669 putative acyl-acceptor binding pocket; other site 56107013670 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 56107013671 active site 56107013672 catalytic triad [active] 56107013673 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 56107013674 BolA-like protein; Region: BolA; pfam01722 56107013675 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 56107013676 putative GSH binding site [chemical binding]; other site 56107013677 catalytic residues [active] 56107013678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 56107013679 PAS fold; Region: PAS_3; pfam08447 56107013680 putative active site [active] 56107013681 heme pocket [chemical binding]; other site 56107013682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107013683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107013684 dimer interface [polypeptide binding]; other site 56107013685 phosphorylation site [posttranslational modification] 56107013686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107013687 ATP binding site [chemical binding]; other site 56107013688 Mg2+ binding site [ion binding]; other site 56107013689 G-X-G motif; other site 56107013690 Response regulator receiver domain; Region: Response_reg; pfam00072 56107013691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107013692 active site 56107013693 phosphorylation site [posttranslational modification] 56107013694 intermolecular recognition site; other site 56107013695 dimerization interface [polypeptide binding]; other site 56107013696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 56107013697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107013698 active site 56107013699 phosphorylation site [posttranslational modification] 56107013700 intermolecular recognition site; other site 56107013701 dimerization interface [polypeptide binding]; other site 56107013702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107013703 DNA binding site [nucleotide binding] 56107013704 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 56107013705 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 56107013706 Walker A/P-loop; other site 56107013707 ATP binding site [chemical binding]; other site 56107013708 Q-loop/lid; other site 56107013709 ABC transporter signature motif; other site 56107013710 Walker B; other site 56107013711 D-loop; other site 56107013712 H-loop/switch region; other site 56107013713 Neogenin C-terminus; Region: Neogenin_C; pfam06583 56107013714 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 56107013715 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 56107013716 Surface antigen; Region: Bac_surface_Ag; pfam01103 56107013717 haemagglutination activity domain; Region: Haemagg_act; pfam05860 56107013718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 56107013719 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 56107013720 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107013721 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107013722 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 56107013723 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 56107013724 metal binding site [ion binding]; metal-binding site 56107013725 active site 56107013726 I-site; other site 56107013727 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 56107013728 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 56107013729 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 56107013730 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 56107013731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107013732 FeS/SAM binding site; other site 56107013733 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 56107013734 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 56107013735 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 56107013736 Zn2+ binding site [ion binding]; other site 56107013737 Mg2+ binding site [ion binding]; other site 56107013738 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107013739 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107013740 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107013741 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107013742 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107013743 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 56107013744 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 56107013745 CAAX protease self-immunity; Region: Abi; pfam02517 56107013746 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 56107013747 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 56107013748 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 56107013749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107013750 homodimer interface [polypeptide binding]; other site 56107013751 catalytic residue [active] 56107013752 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 56107013753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107013754 FeS/SAM binding site; other site 56107013755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 56107013756 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 56107013757 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 56107013758 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 56107013759 homodimer interface [polypeptide binding]; other site 56107013760 oligonucleotide binding site [chemical binding]; other site 56107013761 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 56107013762 RNA/DNA hybrid binding site [nucleotide binding]; other site 56107013763 active site 56107013764 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 56107013765 prephenate dehydratase; Provisional; Region: PRK11898 56107013766 Prephenate dehydratase; Region: PDT; pfam00800 56107013767 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 56107013768 putative L-Phe binding site [chemical binding]; other site 56107013769 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 56107013770 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 56107013771 elongation factor Tu; Region: tufA; CHL00071 56107013772 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 56107013773 G1 box; other site 56107013774 GEF interaction site [polypeptide binding]; other site 56107013775 GTP/Mg2+ binding site [chemical binding]; other site 56107013776 Switch I region; other site 56107013777 G2 box; other site 56107013778 G3 box; other site 56107013779 Switch II region; other site 56107013780 G4 box; other site 56107013781 G5 box; other site 56107013782 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 56107013783 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 56107013784 Antibiotic Binding Site [chemical binding]; other site 56107013785 elongation factor G; Reviewed; Region: PRK00007 56107013786 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 56107013787 G1 box; other site 56107013788 putative GEF interaction site [polypeptide binding]; other site 56107013789 GTP/Mg2+ binding site [chemical binding]; other site 56107013790 Switch I region; other site 56107013791 G2 box; other site 56107013792 G3 box; other site 56107013793 Switch II region; other site 56107013794 G4 box; other site 56107013795 G5 box; other site 56107013796 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 56107013797 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 56107013798 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 56107013799 30S ribosomal protein S7; Validated; Region: PRK05302 56107013800 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 56107013801 S17 interaction site [polypeptide binding]; other site 56107013802 S8 interaction site; other site 56107013803 16S rRNA interaction site [nucleotide binding]; other site 56107013804 streptomycin interaction site [chemical binding]; other site 56107013805 23S rRNA interaction site [nucleotide binding]; other site 56107013806 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 56107013807 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 56107013808 Cupin domain; Region: Cupin_2; cl17218 56107013809 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 56107013810 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 56107013811 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 56107013812 active site 56107013813 dimer interface [polypeptide binding]; other site 56107013814 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 56107013815 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 56107013816 active site 56107013817 FMN binding site [chemical binding]; other site 56107013818 substrate binding site [chemical binding]; other site 56107013819 3Fe-4S cluster binding site [ion binding]; other site 56107013820 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 56107013821 domain interface; other site 56107013822 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 56107013823 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 56107013824 NodB motif; other site 56107013825 active site 56107013826 catalytic site [active] 56107013827 metal binding site [ion binding]; metal-binding site 56107013828 Uncharacterized protein family UPF0546; Region: UPF0546; pfam10639 56107013829 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 56107013830 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 56107013831 Ligand binding site; other site 56107013832 Putative Catalytic site; other site 56107013833 DXD motif; other site 56107013834 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 56107013835 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 56107013836 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 56107013837 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 56107013838 Predicted membrane protein [Function unknown]; Region: COG3463 56107013839 Predicted membrane protein [Function unknown]; Region: COG3463 56107013840 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 56107013841 Predicted membrane protein [Function unknown]; Region: COG3463 56107013842 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 56107013843 Predicted integral membrane protein [Function unknown]; Region: COG5542 56107013844 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 56107013845 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 56107013846 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 56107013847 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 56107013848 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 56107013849 active site 56107013850 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 56107013851 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 56107013852 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 56107013853 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 56107013854 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 56107013855 CbbX; Provisional; Region: cbbX; CHL00181 56107013856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107013857 Walker A motif; other site 56107013858 ATP binding site [chemical binding]; other site 56107013859 Walker B motif; other site 56107013860 arginine finger; other site 56107013861 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 56107013862 active site 56107013863 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107013864 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107013865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107013866 binding surface 56107013867 TPR motif; other site 56107013868 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107013869 large tegument protein UL36; Provisional; Region: PHA03247 56107013870 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 56107013871 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 56107013872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107013873 dimer interface [polypeptide binding]; other site 56107013874 phosphorylation site [posttranslational modification] 56107013875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107013876 ATP binding site [chemical binding]; other site 56107013877 Mg2+ binding site [ion binding]; other site 56107013878 G-X-G motif; other site 56107013879 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 56107013880 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 56107013881 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 56107013882 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 56107013883 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 56107013884 polyphosphate kinase; Provisional; Region: PRK05443 56107013885 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 56107013886 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 56107013887 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 56107013888 putative domain interface [polypeptide binding]; other site 56107013889 putative active site [active] 56107013890 catalytic site [active] 56107013891 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 56107013892 putative domain interface [polypeptide binding]; other site 56107013893 putative active site [active] 56107013894 catalytic site [active] 56107013895 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107013896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107013897 active site 56107013898 phosphorylation site [posttranslational modification] 56107013899 intermolecular recognition site; other site 56107013900 dimerization interface [polypeptide binding]; other site 56107013901 Response regulator receiver domain; Region: Response_reg; pfam00072 56107013902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107013903 active site 56107013904 phosphorylation site [posttranslational modification] 56107013905 intermolecular recognition site; other site 56107013906 dimerization interface [polypeptide binding]; other site 56107013907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 56107013908 dimer interface [polypeptide binding]; other site 56107013909 phosphorylation site [posttranslational modification] 56107013910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107013911 ATP binding site [chemical binding]; other site 56107013912 G-X-G motif; other site 56107013913 GAF domain; Region: GAF; pfam01590 56107013914 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107013915 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107013916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107013917 dimer interface [polypeptide binding]; other site 56107013918 phosphorylation site [posttranslational modification] 56107013919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107013920 ATP binding site [chemical binding]; other site 56107013921 Mg2+ binding site [ion binding]; other site 56107013922 G-X-G motif; other site 56107013923 Response regulator receiver domain; Region: Response_reg; pfam00072 56107013924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107013925 active site 56107013926 phosphorylation site [posttranslational modification] 56107013927 intermolecular recognition site; other site 56107013928 dimerization interface [polypeptide binding]; other site 56107013929 tellurium resistance terB-like protein; Region: terB_like; cl11965 56107013930 metal binding site [ion binding]; metal-binding site 56107013931 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 56107013932 Mechanosensitive ion channel; Region: MS_channel; pfam00924 56107013933 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 56107013934 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 56107013935 Response regulator receiver domain; Region: Response_reg; pfam00072 56107013936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107013937 active site 56107013938 phosphorylation site [posttranslational modification] 56107013939 intermolecular recognition site; other site 56107013940 dimerization interface [polypeptide binding]; other site 56107013941 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 56107013942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 56107013943 metal binding site [ion binding]; metal-binding site 56107013944 active site 56107013945 I-site; other site 56107013946 adaptive-response sensory kinase; Validated; Region: PRK09303 56107013947 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 56107013948 tetramer interface [polypeptide binding]; other site 56107013949 dimer interface [polypeptide binding]; other site 56107013950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107013951 dimer interface [polypeptide binding]; other site 56107013952 phosphorylation site [posttranslational modification] 56107013953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107013954 ATP binding site [chemical binding]; other site 56107013955 Mg2+ binding site [ion binding]; other site 56107013956 G-X-G motif; other site 56107013957 S-layer homology domain; Region: SLH; pfam00395 56107013958 S-layer homology domain; Region: SLH; pfam00395 56107013959 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 56107013960 active site 56107013961 catalytic triad [active] 56107013962 oxyanion hole [active] 56107013963 hypothetical protein; Provisional; Region: PRK06208 56107013964 intersubunit interface [polypeptide binding]; other site 56107013965 active site 56107013966 Zn2+ binding site [ion binding]; other site 56107013967 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 56107013968 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 56107013969 M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343 56107013970 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 56107013971 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 56107013972 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 56107013973 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107013974 putative active site [active] 56107013975 HsdM N-terminal domain; Region: HsdM_N; pfam12161 56107013976 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 56107013977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 56107013978 FlxA-like protein; Region: FlxA; pfam14282 56107013979 Transposase IS200 like; Region: Y1_Tnp; cl00848 56107013980 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 56107013981 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 56107013982 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107013983 ATP binding site [chemical binding]; other site 56107013984 putative Mg++ binding site [ion binding]; other site 56107013985 nucleotide binding region [chemical binding]; other site 56107013986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 56107013987 ATP-binding site [chemical binding]; other site 56107013988 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 56107013989 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 56107013990 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 56107013991 S-layer homology domain; Region: SLH; pfam00395 56107013992 S-layer homology domain; Region: SLH; pfam00395 56107013993 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 56107013994 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 56107013995 translation initiation factor IF-2; Region: IF-2; TIGR00487 56107013996 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 56107013997 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 56107013998 G1 box; other site 56107013999 putative GEF interaction site [polypeptide binding]; other site 56107014000 GTP/Mg2+ binding site [chemical binding]; other site 56107014001 Switch I region; other site 56107014002 G2 box; other site 56107014003 G3 box; other site 56107014004 Switch II region; other site 56107014005 G4 box; other site 56107014006 G5 box; other site 56107014007 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 56107014008 Translation-initiation factor 2; Region: IF-2; pfam11987 56107014009 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 56107014010 Protein of unknown function (DUF448); Region: DUF448; pfam04296 56107014011 putative RNA binding cleft [nucleotide binding]; other site 56107014012 NusA N-terminal domain; Region: NusA_N; pfam08529 56107014013 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 56107014014 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 56107014015 RNA binding site [nucleotide binding]; other site 56107014016 homodimer interface [polypeptide binding]; other site 56107014017 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 56107014018 G-X-X-G motif; other site 56107014019 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 56107014020 G-X-X-G motif; other site 56107014021 ribosome maturation protein RimP; Reviewed; Region: PRK00092 56107014022 Sm and related proteins; Region: Sm_like; cl00259 56107014023 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 56107014024 putative oligomer interface [polypeptide binding]; other site 56107014025 putative RNA binding site [nucleotide binding]; other site 56107014026 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 56107014027 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107014028 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107014029 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 56107014030 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 56107014031 active site 56107014032 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107014033 putative active site [active] 56107014034 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 56107014035 putative active site [active] 56107014036 DNA repair protein RadA; Provisional; Region: PRK11823 56107014037 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 56107014038 Walker A motif/ATP binding site; other site 56107014039 ATP binding site [chemical binding]; other site 56107014040 Walker B motif; other site 56107014041 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 56107014042 Ycf27; Reviewed; Region: orf27; CHL00148 56107014043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107014044 active site 56107014045 phosphorylation site [posttranslational modification] 56107014046 intermolecular recognition site; other site 56107014047 dimerization interface [polypeptide binding]; other site 56107014048 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 56107014049 DNA binding site [nucleotide binding] 56107014050 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 56107014051 Protein of unknown function (DUF456); Region: DUF456; cl01069 56107014052 HEAT repeats; Region: HEAT_2; pfam13646 56107014053 HEAT repeats; Region: HEAT_2; pfam13646 56107014054 FOG: CBS domain [General function prediction only]; Region: COG0517 56107014055 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 56107014056 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 56107014057 active site 56107014058 8-oxo-dGMP binding site [chemical binding]; other site 56107014059 nudix motif; other site 56107014060 metal binding site [ion binding]; metal-binding site 56107014061 Protein of unknown function (DUF760); Region: DUF760; pfam05542 56107014062 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 56107014063 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 56107014064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 56107014065 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 56107014066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 56107014067 DNA binding residues [nucleotide binding] 56107014068 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 56107014069 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 56107014070 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 56107014071 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 56107014072 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 56107014073 ATP-grasp domain; Region: ATP-grasp_4; cl17255 56107014074 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 56107014075 IMP binding site; other site 56107014076 dimer interface [polypeptide binding]; other site 56107014077 interdomain contacts; other site 56107014078 partial ornithine binding site; other site 56107014079 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 56107014080 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 56107014081 dimerization interface [polypeptide binding]; other site 56107014082 DPS ferroxidase diiron center [ion binding]; other site 56107014083 ion pore; other site 56107014084 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 56107014085 dimer interface [polypeptide binding]; other site 56107014086 [2Fe-2S] cluster binding site [ion binding]; other site 56107014087 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 56107014088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 56107014089 dimer interface [polypeptide binding]; other site 56107014090 conserved gate region; other site 56107014091 ABC-ATPase subunit interface; other site 56107014092 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 56107014093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107014094 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 56107014095 Walker A/P-loop; other site 56107014096 ATP binding site [chemical binding]; other site 56107014097 Q-loop/lid; other site 56107014098 ABC transporter signature motif; other site 56107014099 Walker B; other site 56107014100 D-loop; other site 56107014101 H-loop/switch region; other site 56107014102 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 56107014103 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107014104 substrate binding pocket [chemical binding]; other site 56107014105 membrane-bound complex binding site; other site 56107014106 hinge residues; other site 56107014107 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107014108 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107014109 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107014110 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107014111 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107014112 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107014113 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107014114 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107014115 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107014116 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107014117 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107014118 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107014119 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 56107014120 homotrimer interaction site [polypeptide binding]; other site 56107014121 putative active site [active] 56107014122 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 56107014123 nudix motif; other site 56107014124 4-alpha-glucanotransferase; Provisional; Region: PRK14508 56107014125 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 56107014126 Helix-turn-helix domain; Region: HTH_25; pfam13413 56107014127 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 56107014128 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 56107014129 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 56107014130 RNA binding surface [nucleotide binding]; other site 56107014131 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 56107014132 active site 56107014133 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 56107014134 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 56107014135 phosphatidate cytidylyltransferase; Region: PLN02953 56107014136 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 56107014137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107014138 S-adenosylmethionine binding site [chemical binding]; other site 56107014139 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107014140 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107014141 active site 56107014142 ATP binding site [chemical binding]; other site 56107014143 substrate binding site [chemical binding]; other site 56107014144 activation loop (A-loop); other site 56107014145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107014146 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107014147 active site 56107014148 ATP binding site [chemical binding]; other site 56107014149 substrate binding site [chemical binding]; other site 56107014150 activation loop (A-loop); other site 56107014151 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 56107014152 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 56107014153 ATP-grasp domain; Region: ATP-grasp_4; cl17255 56107014154 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 56107014155 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 56107014156 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 56107014157 proposed catalytic triad [active] 56107014158 active site nucleophile [active] 56107014159 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 56107014160 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 56107014161 homotrimer interaction site [polypeptide binding]; other site 56107014162 zinc binding site [ion binding]; other site 56107014163 CDP-binding sites; other site 56107014164 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 56107014165 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 56107014166 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 56107014167 AIR carboxylase; Region: AIRC; smart01001 56107014168 argininosuccinate lyase; Provisional; Region: PRK00855 56107014169 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 56107014170 active sites [active] 56107014171 tetramer interface [polypeptide binding]; other site 56107014172 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 56107014173 nudix motif; other site 56107014174 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 56107014175 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 56107014176 catalytic site [active] 56107014177 pantothenate kinase; Reviewed; Region: PRK13331 56107014178 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 56107014179 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 56107014180 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 56107014181 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 56107014182 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 56107014183 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 56107014184 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 56107014185 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 56107014186 oligomeric interface; other site 56107014187 putative active site [active] 56107014188 homodimer interface [polypeptide binding]; other site 56107014189 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 56107014190 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 56107014191 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107014192 putative active site [active] 56107014193 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 56107014194 GIY-YIG motif/motif A; other site 56107014195 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107014196 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107014197 active site 56107014198 ATP binding site [chemical binding]; other site 56107014199 substrate binding site [chemical binding]; other site 56107014200 activation loop (A-loop); other site 56107014201 YARHG domain; Region: YARHG; pfam13308 56107014202 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 56107014203 putative hydrophobic ligand binding site [chemical binding]; other site 56107014204 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107014205 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107014206 active site 56107014207 ATP binding site [chemical binding]; other site 56107014208 substrate binding site [chemical binding]; other site 56107014209 activation loop (A-loop); other site 56107014210 S-layer homology domain; Region: SLH; pfam00395 56107014211 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 56107014212 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 56107014213 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 56107014214 peripheral dimer interface [polypeptide binding]; other site 56107014215 core dimer interface [polypeptide binding]; other site 56107014216 L10 interface [polypeptide binding]; other site 56107014217 L11 interface [polypeptide binding]; other site 56107014218 putative EF-Tu interaction site [polypeptide binding]; other site 56107014219 putative EF-G interaction site [polypeptide binding]; other site 56107014220 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 56107014221 23S rRNA interface [nucleotide binding]; other site 56107014222 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 56107014223 Ribosomal protein L10 leader; IMG reference gene:2509771195; Cylst_5155 56107014224 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 56107014225 mRNA/rRNA interface [nucleotide binding]; other site 56107014226 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 56107014227 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 56107014228 23S rRNA interface [nucleotide binding]; other site 56107014229 L7/L12 interface [polypeptide binding]; other site 56107014230 putative thiostrepton binding site; other site 56107014231 L25 interface [polypeptide binding]; other site 56107014232 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 56107014233 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 56107014234 putative homodimer interface [polypeptide binding]; other site 56107014235 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 56107014236 heterodimer interface [polypeptide binding]; other site 56107014237 homodimer interface [polypeptide binding]; other site 56107014238 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 56107014239 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 56107014240 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107014241 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107014242 active site 56107014243 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 56107014244 Protein export membrane protein; Region: SecD_SecF; cl14618 56107014245 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 56107014246 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107014247 CpeS-like protein; Region: CpeS; pfam09367 56107014248 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 56107014249 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 56107014250 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 56107014251 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 56107014252 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 56107014253 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 56107014254 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 56107014255 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 56107014256 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 56107014257 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 56107014258 DNA binding site [nucleotide binding] 56107014259 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 56107014260 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 56107014261 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 56107014262 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 56107014263 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 56107014264 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 56107014265 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 56107014266 active site 56107014267 catalytic site [active] 56107014268 substrate binding site [chemical binding]; other site 56107014269 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 56107014270 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107014271 active site 56107014272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107014273 non-specific DNA binding site [nucleotide binding]; other site 56107014274 salt bridge; other site 56107014275 sequence-specific DNA binding site [nucleotide binding]; other site 56107014276 Restriction endonuclease; Region: Mrr_cat; pfam04471 56107014277 NACHT domain; Region: NACHT; pfam05729 56107014278 AAA-like domain; Region: AAA_10; pfam12846 56107014279 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 56107014280 AAA domain; Region: AAA_22; pfam13401 56107014281 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 56107014282 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107014283 P-loop; other site 56107014284 Magnesium ion binding site [ion binding]; other site 56107014285 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107014286 Magnesium ion binding site [ion binding]; other site 56107014287 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 56107014288 ParB-like nuclease domain; Region: ParBc; pfam02195 56107014289 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 56107014290 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 56107014291 HTH domain; Region: HTH_11; cl17392 56107014292 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107014293 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 56107014294 EF-hand domain pair; Region: EF_hand_5; pfam13499 56107014295 Ca2+ binding site [ion binding]; other site 56107014296 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 56107014297 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 56107014298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107014299 active site 56107014300 motif I; other site 56107014301 motif II; other site 56107014302 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 56107014303 Staphylococcal nuclease homologues; Region: SNc; smart00318 56107014304 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 56107014305 Catalytic site; other site 56107014306 Nuclease-related domain; Region: NERD; pfam08378 56107014307 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 56107014308 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 56107014309 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107014310 ATP binding site [chemical binding]; other site 56107014311 putative Mg++ binding site [ion binding]; other site 56107014312 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 56107014313 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 56107014314 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 56107014315 HsdM N-terminal domain; Region: HsdM_N; pfam12161 56107014316 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 56107014317 Methyltransferase domain; Region: Methyltransf_26; pfam13659 56107014318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107014319 non-specific DNA binding site [nucleotide binding]; other site 56107014320 salt bridge; other site 56107014321 sequence-specific DNA binding site [nucleotide binding]; other site 56107014322 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 56107014323 Staphylococcal nuclease homologues; Region: SNc; smart00318 56107014324 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 56107014325 Catalytic site; other site 56107014326 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 56107014327 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 56107014328 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 56107014329 active site 56107014330 substrate binding site [chemical binding]; other site 56107014331 Mg2+ binding site [ion binding]; other site 56107014332 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107014333 DNA binding site [nucleotide binding] 56107014334 Int/Topo IB signature motif; other site 56107014335 active site 56107014336 catalytic residues [active] 56107014337 Secretory pathway protein Sec39; Region: Sec39; pfam08314 56107014338 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 56107014339 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 56107014340 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 56107014341 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 56107014342 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 56107014343 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 56107014344 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 56107014345 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 56107014346 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 56107014347 DNA binding site [nucleotide binding] 56107014348 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 56107014349 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 56107014350 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 56107014351 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 56107014352 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 56107014353 RPB10 interaction site [polypeptide binding]; other site 56107014354 RPB1 interaction site [polypeptide binding]; other site 56107014355 RPB11 interaction site [polypeptide binding]; other site 56107014356 RPB3 interaction site [polypeptide binding]; other site 56107014357 RPB12 interaction site [polypeptide binding]; other site 56107014358 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 56107014359 active site 56107014360 ribosomal protein S20; Region: rps20; CHL00102 56107014361 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 56107014362 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 56107014363 NAD binding site [chemical binding]; other site 56107014364 dimerization interface [polypeptide binding]; other site 56107014365 product binding site; other site 56107014366 substrate binding site [chemical binding]; other site 56107014367 zinc binding site [ion binding]; other site 56107014368 catalytic residues [active] 56107014369 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 56107014370 Ligand Binding Site [chemical binding]; other site 56107014371 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 56107014372 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 56107014373 dimerization interface [polypeptide binding]; other site 56107014374 domain crossover interface; other site 56107014375 redox-dependent activation switch; other site 56107014376 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107014377 putative active site [active] 56107014378 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 56107014379 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 56107014380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107014381 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 56107014382 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 56107014383 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 56107014384 Phosphotransferase enzyme family; Region: APH; pfam01636 56107014385 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 56107014386 active site 56107014387 ATP binding site [chemical binding]; other site 56107014388 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 56107014389 substrate binding site [chemical binding]; other site 56107014390 WYL domain; Region: WYL; pfam13280 56107014391 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 56107014392 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 56107014393 Protein of unknown function (DUF433); Region: DUF433; pfam04255 56107014394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 56107014395 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 56107014396 CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174 56107014397 CRISPR type I-D/CYANO-associated protein Csc2; Region: cas_Csc2; TIGR03157 56107014398 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 56107014399 CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159 56107014400 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 56107014401 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 56107014402 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 56107014403 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 56107014404 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 56107014405 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 56107014406 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 56107014407 NAD(P) binding site [chemical binding]; other site 56107014408 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 56107014409 putative catalytic site [active] 56107014410 putative phosphate binding site [ion binding]; other site 56107014411 active site 56107014412 metal binding site A [ion binding]; metal-binding site 56107014413 DNA binding site [nucleotide binding] 56107014414 putative AP binding site [nucleotide binding]; other site 56107014415 putative metal binding site B [ion binding]; other site 56107014416 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 56107014417 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 56107014418 NAD(P) binding site [chemical binding]; other site 56107014419 putative active site [active] 56107014420 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 56107014421 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 56107014422 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107014423 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 56107014424 active site 56107014425 catalytic triad [active] 56107014426 CARDB; Region: CARDB; pfam07705 56107014427 Uncharacterized conserved protein [Function unknown]; Region: COG1572 56107014428 CARDB; Region: CARDB; pfam07705 56107014429 CARDB; Region: CARDB; pfam07705 56107014430 CARDB; Region: CARDB; pfam07705 56107014431 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107014432 putative active site [active] 56107014433 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 56107014434 PIN domain; Region: PIN; pfam01850 56107014435 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 56107014436 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 56107014437 putative active site [active] 56107014438 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107014439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107014440 Walker A/P-loop; other site 56107014441 ATP binding site [chemical binding]; other site 56107014442 Q-loop/lid; other site 56107014443 ABC transporter signature motif; other site 56107014444 Walker B; other site 56107014445 D-loop; other site 56107014446 H-loop/switch region; other site 56107014447 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 56107014448 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 56107014449 Integral membrane protein DUF92; Region: DUF92; pfam01940 56107014450 Lipase (class 2); Region: Lipase_2; pfam01674 56107014451 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 56107014452 RNA methyltransferase, RsmE family; Region: TIGR00046 56107014453 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 56107014454 ferredoxin-sulfite reductase; Region: sir; TIGR02042 56107014455 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 56107014456 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 56107014457 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 56107014458 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 56107014459 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 56107014460 DNA-binding interface [nucleotide binding]; DNA binding site 56107014461 Protein of unknown function (DUF3257); Region: DUF3257; pfam11645 56107014462 Competence protein CoiA-like family; Region: CoiA; cl11541 56107014463 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 56107014464 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107014465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107014466 Walker A/P-loop; other site 56107014467 ATP binding site [chemical binding]; other site 56107014468 Q-loop/lid; other site 56107014469 ABC transporter signature motif; other site 56107014470 Walker B; other site 56107014471 D-loop; other site 56107014472 H-loop/switch region; other site 56107014473 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 56107014474 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 56107014475 PhoH-like protein; Region: PhoH; pfam02562 56107014476 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 56107014477 KH domain; Region: KH_4; pfam13083 56107014478 ribosomal protein S16; Region: rps16; CHL00005 56107014479 signal recognition particle protein; Provisional; Region: PRK10867 56107014480 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 56107014481 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 56107014482 P loop; other site 56107014483 GTP binding site [chemical binding]; other site 56107014484 Signal peptide binding domain; Region: SRP_SPB; pfam02978 56107014485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 56107014486 non-specific DNA binding site [nucleotide binding]; other site 56107014487 salt bridge; other site 56107014488 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 56107014489 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107014490 putative active site [active] 56107014491 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 56107014492 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 56107014493 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 56107014494 active site 56107014495 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 56107014496 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 56107014497 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 56107014498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 56107014499 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 56107014500 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 56107014501 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 56107014502 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 56107014503 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 56107014504 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 56107014505 Phosphotransferase enzyme family; Region: APH; pfam01636 56107014506 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 56107014507 substrate binding site [chemical binding]; other site 56107014508 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 56107014509 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 56107014510 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 56107014511 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 56107014512 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 56107014513 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 56107014514 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107014515 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107014516 ligand binding site [chemical binding]; other site 56107014517 flexible hinge region; other site 56107014518 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 56107014519 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 56107014520 putative active site [active] 56107014521 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107014522 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 56107014523 Walker A/P-loop; other site 56107014524 ATP binding site [chemical binding]; other site 56107014525 Q-loop/lid; other site 56107014526 ABC transporter signature motif; other site 56107014527 Walker B; other site 56107014528 D-loop; other site 56107014529 H-loop/switch region; other site 56107014530 Homeodomain-like domain; Region: HTH_23; pfam13384 56107014531 Winged helix-turn helix; Region: HTH_29; pfam13551 56107014532 Winged helix-turn helix; Region: HTH_33; pfam13592 56107014533 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 56107014534 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 56107014535 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107014536 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107014537 ligand binding site [chemical binding]; other site 56107014538 flexible hinge region; other site 56107014539 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 56107014540 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 56107014541 putative active site [active] 56107014542 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107014543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107014544 Walker A/P-loop; other site 56107014545 ATP binding site [chemical binding]; other site 56107014546 Q-loop/lid; other site 56107014547 ABC transporter signature motif; other site 56107014548 Walker B; other site 56107014549 D-loop; other site 56107014550 H-loop/switch region; other site 56107014551 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 56107014552 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 56107014553 Protein of unknown function, DUF608; Region: DUF608; pfam04685 56107014554 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283 56107014555 nad+ binding pocket [chemical binding]; other site 56107014556 PemK-like protein; Region: PemK; pfam02452 56107014557 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 56107014558 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 56107014559 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 56107014560 protein binding site [polypeptide binding]; other site 56107014561 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 56107014562 putative homodimer interface [polypeptide binding]; other site 56107014563 putative homotetramer interface [polypeptide binding]; other site 56107014564 putative metal binding site [ion binding]; other site 56107014565 putative homodimer-homodimer interface [polypeptide binding]; other site 56107014566 putative allosteric switch controlling residues; other site 56107014567 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 56107014568 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 56107014569 N-acetyl-D-glucosamine binding site [chemical binding]; other site 56107014570 catalytic residue [active] 56107014571 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 56107014572 NADH(P)-binding; Region: NAD_binding_10; pfam13460 56107014573 NAD(P) binding site [chemical binding]; other site 56107014574 putative active site [active] 56107014575 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 56107014576 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 56107014577 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 56107014578 SmpB-tmRNA interface; other site 56107014579 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 56107014580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107014581 active site 56107014582 phosphorylation site [posttranslational modification] 56107014583 intermolecular recognition site; other site 56107014584 dimerization interface [polypeptide binding]; other site 56107014585 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107014586 DNA binding residues [nucleotide binding] 56107014587 dimerization interface [polypeptide binding]; other site 56107014588 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 56107014589 Low molecular weight phosphatase family; Region: LMWPc; cd00115 56107014590 active site 56107014591 hypothetical protein; Validated; Region: PRK00153 56107014592 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 56107014593 FAD binding domain; Region: FAD_binding_4; pfam01565 56107014594 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 56107014595 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 56107014596 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 56107014597 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 56107014598 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 56107014599 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 56107014600 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 56107014601 active site 56107014602 (T/H)XGH motif; other site 56107014603 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 56107014604 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 56107014605 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 56107014606 thiamine monophosphate kinase; Provisional; Region: PRK05731 56107014607 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 56107014608 ATP binding site [chemical binding]; other site 56107014609 dimerization interface [polypeptide binding]; other site 56107014610 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 56107014611 active site 56107014612 elongation factor P; Validated; Region: PRK00529 56107014613 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 56107014614 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 56107014615 RNA binding site [nucleotide binding]; other site 56107014616 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 56107014617 RNA binding site [nucleotide binding]; other site 56107014618 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 56107014619 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 56107014620 carboxyltransferase (CT) interaction site; other site 56107014621 biotinylation site [posttranslational modification]; other site 56107014622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 56107014623 dimerization interface [polypeptide binding]; other site 56107014624 putative DNA binding site [nucleotide binding]; other site 56107014625 putative Zn2+ binding site [ion binding]; other site 56107014626 Sporulation and spore germination; Region: Germane; pfam10646 56107014627 prolyl-tRNA synthetase; Provisional; Region: PRK09194 56107014628 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 56107014629 dimer interface [polypeptide binding]; other site 56107014630 motif 1; other site 56107014631 active site 56107014632 motif 2; other site 56107014633 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 56107014634 putative deacylase active site [active] 56107014635 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 56107014636 active site 56107014637 motif 3; other site 56107014638 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 56107014639 anticodon binding site; other site 56107014640 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 56107014641 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107014642 putative active site [active] 56107014643 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 56107014644 dimer interface [polypeptide binding]; other site 56107014645 [2Fe-2S] cluster binding site [ion binding]; other site 56107014646 NifT/FixU protein; Region: NifT; pfam06988 56107014647 NifZ domain; Region: NifZ; pfam04319 56107014648 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 56107014649 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 56107014650 active site 56107014651 catalytic residues [active] 56107014652 metal binding site [ion binding]; metal-binding site 56107014653 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 56107014654 serine O-acetyltransferase; Region: cysE; TIGR01172 56107014655 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 56107014656 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 56107014657 trimer interface [polypeptide binding]; other site 56107014658 active site 56107014659 substrate binding site [chemical binding]; other site 56107014660 CoA binding site [chemical binding]; other site 56107014661 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 56107014662 putative active site [active] 56107014663 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 56107014664 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 56107014665 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 56107014666 putative NAD(P) binding site [chemical binding]; other site 56107014667 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 56107014668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 56107014669 FeS/SAM binding site; other site 56107014670 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 56107014671 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 56107014672 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 56107014673 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 56107014674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 56107014675 catalytic residue [active] 56107014676 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 56107014677 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 56107014678 trimerization site [polypeptide binding]; other site 56107014679 active site 56107014680 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 56107014681 Poxvirus A3L Protein; Region: Pox_A3L; cl17407 56107014682 NifU-like domain; Region: NifU; pfam01106 56107014683 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 56107014684 apolar tunnel; other site 56107014685 heme binding site [chemical binding]; other site 56107014686 dimerization interface [polypeptide binding]; other site 56107014687 nitrogenase reductase; Reviewed; Region: PRK13236 56107014688 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 56107014689 Nucleotide-binding sites [chemical binding]; other site 56107014690 Walker A motif; other site 56107014691 Switch I region of nucleotide binding site; other site 56107014692 Fe4S4 binding sites [ion binding]; other site 56107014693 Switch II region of nucleotide binding site; other site 56107014694 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107014695 active site 56107014696 catalytic residues [active] 56107014697 DNA binding site [nucleotide binding] 56107014698 Int/Topo IB signature motif; other site 56107014699 Protein of unknown function (DUF972); Region: DUF972; pfam06156 56107014700 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107014701 putative active site [active] 56107014702 KilA-N domain; Region: KilA-N; pfam04383 56107014703 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 56107014704 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 56107014705 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 56107014706 Adenoviral DNA terminal protein; Region: Adeno_terminal; pfam02459 56107014707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107014708 AAA domain; Region: AAA_21; pfam13304 56107014709 Walker A/P-loop; other site 56107014710 ATP binding site [chemical binding]; other site 56107014711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 56107014712 Walker B; other site 56107014713 D-loop; other site 56107014714 H-loop/switch region; other site 56107014715 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107014716 active site 56107014717 catalytic residues [active] 56107014718 DNA binding site [nucleotide binding] 56107014719 Int/Topo IB signature motif; other site 56107014720 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 56107014721 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 56107014722 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 56107014723 MoFe protein beta/alpha subunit interactions; other site 56107014724 Beta subunit P cluster binding residues; other site 56107014725 MoFe protein beta subunit/Fe protein contacts; other site 56107014726 MoFe protein dimer/ dimer interactions; other site 56107014727 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 56107014728 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 56107014729 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 56107014730 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 56107014731 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 56107014732 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 56107014733 Protein of unknown function, DUF269; Region: DUF269; pfam03270 56107014734 Rop-like; Region: Rop-like; pfam05082 56107014735 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102 56107014736 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 56107014737 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 56107014738 ATP binding site [chemical binding]; other site 56107014739 substrate interface [chemical binding]; other site 56107014740 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 56107014741 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 56107014742 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 56107014743 catalytic loop [active] 56107014744 iron binding site [ion binding]; other site 56107014745 FeoA domain; Region: FeoA; pfam04023 56107014746 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 56107014747 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 56107014748 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 56107014749 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 56107014750 NADPH bind site [chemical binding]; other site 56107014751 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 56107014752 putative FMN binding site [chemical binding]; other site 56107014753 NADPH bind site [chemical binding]; other site 56107014754 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063 56107014755 nickel binding site [ion binding]; other site 56107014756 SET domain; Region: SET; pfam00856 56107014757 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 56107014758 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107014759 active site 56107014760 catalytic residues [active] 56107014761 DNA binding site [nucleotide binding] 56107014762 Int/Topo IB signature motif; other site 56107014763 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 56107014764 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 56107014765 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107014766 active site 56107014767 FixH; Region: FixH; pfam05751 56107014768 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 56107014769 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 56107014770 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 56107014771 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 56107014772 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 56107014773 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 56107014774 iron-sulfur cluster [ion binding]; other site 56107014775 [2Fe-2S] cluster binding site [ion binding]; other site 56107014776 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 56107014777 Acylphosphatase; Region: Acylphosphatase; pfam00708 56107014778 HypF finger; Region: zf-HYPF; pfam07503 56107014779 HypF finger; Region: zf-HYPF; pfam07503 56107014780 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 56107014781 HupF/HypC family; Region: HupF_HypC; pfam01455 56107014782 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 56107014783 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 56107014784 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 56107014785 dimerization interface [polypeptide binding]; other site 56107014786 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 56107014787 ATP binding site [chemical binding]; other site 56107014788 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 56107014789 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 56107014790 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 56107014791 G1 box; other site 56107014792 GTP/Mg2+ binding site [chemical binding]; other site 56107014793 G2 box; other site 56107014794 Switch I region; other site 56107014795 G3 box; other site 56107014796 Switch II region; other site 56107014797 G4 box; other site 56107014798 G5 box; other site 56107014799 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107014800 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107014801 active site 56107014802 ATP binding site [chemical binding]; other site 56107014803 substrate binding site [chemical binding]; other site 56107014804 activation loop (A-loop); other site 56107014805 AAA ATPase domain; Region: AAA_16; pfam13191 56107014806 Predicted ATPase [General function prediction only]; Region: COG3899 56107014807 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107014808 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 56107014809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107014810 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 56107014811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107014812 ATP binding site [chemical binding]; other site 56107014813 Mg2+ binding site [ion binding]; other site 56107014814 G-X-G motif; other site 56107014815 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 56107014816 putative active site [active] 56107014817 homotetrameric interface [polypeptide binding]; other site 56107014818 metal binding site [ion binding]; metal-binding site 56107014819 Dynamin family; Region: Dynamin_N; pfam00350 56107014820 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 56107014821 G1 box; other site 56107014822 GTP/Mg2+ binding site [chemical binding]; other site 56107014823 G2 box; other site 56107014824 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 56107014825 G3 box; other site 56107014826 Switch II region; other site 56107014827 GTP/Mg2+ binding site [chemical binding]; other site 56107014828 G4 box; other site 56107014829 G5 box; other site 56107014830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 56107014831 PIN domain; Region: PIN_3; pfam13470 56107014832 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107014833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107014834 S-adenosylmethionine binding site [chemical binding]; other site 56107014835 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 56107014836 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 56107014837 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 56107014838 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 56107014839 dimer interface [polypeptide binding]; other site 56107014840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107014841 catalytic residue [active] 56107014842 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 56107014843 putative active site [active] 56107014844 AAA ATPase domain; Region: AAA_16; pfam13191 56107014845 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107014846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107014847 binding surface 56107014848 TPR motif; other site 56107014849 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107014850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107014851 binding surface 56107014852 TPR motif; other site 56107014853 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107014854 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107014855 Tetratricopeptide repeat; Region: TPR_10; pfam13374 56107014856 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107014857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107014858 binding surface 56107014859 TPR motif; other site 56107014860 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107014861 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 56107014862 YcfA-like protein; Region: YcfA; pfam07927 56107014863 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 56107014864 ArsC family; Region: ArsC; pfam03960 56107014865 putative catalytic residues [active] 56107014866 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 56107014867 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 56107014868 Subunit I/III interface [polypeptide binding]; other site 56107014869 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 56107014870 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 56107014871 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 56107014872 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 56107014873 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 56107014874 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 56107014875 4Fe-4S binding domain; Region: Fer4; cl02805 56107014876 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 56107014877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107014878 non-specific DNA binding site [nucleotide binding]; other site 56107014879 salt bridge; other site 56107014880 sequence-specific DNA binding site [nucleotide binding]; other site 56107014881 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 56107014882 putative dimer interface [polypeptide binding]; other site 56107014883 putative [2Fe-2S] cluster binding site [ion binding]; other site 56107014884 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 56107014885 Uncharacterized conserved protein [Function unknown]; Region: COG1656 56107014886 Protein of unknown function DUF82; Region: DUF82; pfam01927 56107014887 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 56107014888 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 56107014889 nucleotide binding site [chemical binding]; other site 56107014890 Nuclease-related domain; Region: NERD; pfam08378 56107014891 PAS domain S-box; Region: sensory_box; TIGR00229 56107014892 PAS domain; Region: PAS_8; pfam13188 56107014893 putative active site [active] 56107014894 heme pocket [chemical binding]; other site 56107014895 prefoldin subunit beta; Provisional; Region: PRK09343 56107014896 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 56107014897 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 56107014898 metal binding site [ion binding]; metal-binding site 56107014899 active site 56107014900 I-site; other site 56107014901 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 56107014902 TrkA-N domain; Region: TrkA_N; pfam02254 56107014903 Cation transport protein; Region: TrkH; cl17365 56107014904 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 56107014905 TrkA-N domain; Region: TrkA_N; pfam02254 56107014906 Nitrogen fixation protein NifW; Region: NifW; cl03935 56107014907 AAA ATPase domain; Region: AAA_16; pfam13191 56107014908 NACHT domain; Region: NACHT; pfam05729 56107014909 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 56107014910 Phosphotransferase enzyme family; Region: APH; pfam01636 56107014911 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 56107014912 active site 56107014913 ATP binding site [chemical binding]; other site 56107014914 substrate binding site [chemical binding]; other site 56107014915 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 56107014916 active site 56107014917 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 56107014918 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 56107014919 ligand binding site [chemical binding]; other site 56107014920 flexible hinge region; other site 56107014921 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 56107014922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 56107014923 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 56107014924 4Fe-4S binding domain; Region: Fer4_5; pfam12801 56107014925 Class I aldolases; Region: Aldolase_Class_I; cl17187 56107014926 catalytic residue [active] 56107014927 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 56107014928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107014929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 56107014930 putative substrate translocation pore; other site 56107014931 Rubrerythrin [Energy production and conversion]; Region: COG1592 56107014932 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 56107014933 binuclear metal center [ion binding]; other site 56107014934 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 56107014935 iron binding site [ion binding]; other site 56107014936 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107014937 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107014938 structural tetrad; other site 56107014939 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 56107014940 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 56107014941 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 56107014942 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107014943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 56107014944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 56107014945 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 56107014946 putative dimerization interface [polypeptide binding]; other site 56107014947 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 56107014948 Cadmium resistance transporter; Region: Cad; pfam03596 56107014949 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 56107014950 Cadmium resistance transporter; Region: Cad; pfam03596 56107014951 Domain of unknown function (DUF202); Region: DUF202; pfam02656 56107014952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107014953 Probable transposase; Region: OrfB_IS605; pfam01385 56107014954 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107014955 Pirin-related protein [General function prediction only]; Region: COG1741 56107014956 Pirin; Region: Pirin; pfam02678 56107014957 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 56107014958 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 56107014959 dimerization interface [polypeptide binding]; other site 56107014960 DPS ferroxidase diiron center [ion binding]; other site 56107014961 ion pore; other site 56107014962 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 56107014963 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 56107014964 active site 56107014965 catalytic tetrad [active] 56107014966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 56107014967 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 56107014968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 56107014969 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 56107014970 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 56107014971 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107014972 non-specific DNA binding site [nucleotide binding]; other site 56107014973 salt bridge; other site 56107014974 sequence-specific DNA binding site [nucleotide binding]; other site 56107014975 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 56107014976 Domain of unknown function (DUF955); Region: DUF955; pfam06114 56107014977 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 56107014978 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 56107014979 hydroxyglutarate oxidase; Provisional; Region: PRK11728 56107014980 haloalkane dehalogenase; Provisional; Region: PRK03592 56107014981 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 56107014982 putative hydrophobic ligand binding site [chemical binding]; other site 56107014983 protein interface [polypeptide binding]; other site 56107014984 gate; other site 56107014985 Predicted membrane protein [Function unknown]; Region: COG1981 56107014986 Caspase domain; Region: Peptidase_C14; pfam00656 56107014987 Uncharacterized conserved protein [Function unknown]; Region: COG1262 56107014988 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 56107014989 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 56107014990 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107014991 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107014992 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 56107014993 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 56107014994 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 56107014995 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 56107014996 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 56107014997 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 56107014998 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 56107014999 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 56107015000 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 56107015001 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 56107015002 putative active site [active] 56107015003 putative NTP binding site [chemical binding]; other site 56107015004 putative nucleic acid binding site [nucleotide binding]; other site 56107015005 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 56107015006 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107015007 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107015008 active site 56107015009 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 56107015010 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 56107015011 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 56107015012 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 56107015013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107015014 ATP binding site [chemical binding]; other site 56107015015 Mg2+ binding site [ion binding]; other site 56107015016 G-X-G motif; other site 56107015017 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 56107015018 Response regulator receiver domain; Region: Response_reg; pfam00072 56107015019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107015020 active site 56107015021 phosphorylation site [posttranslational modification] 56107015022 intermolecular recognition site; other site 56107015023 dimerization interface [polypeptide binding]; other site 56107015024 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 56107015025 putative binding surface; other site 56107015026 active site 56107015027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 56107015028 dimerization interface [polypeptide binding]; other site 56107015029 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 56107015030 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 56107015031 dimer interface [polypeptide binding]; other site 56107015032 putative CheW interface [polypeptide binding]; other site 56107015033 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 56107015034 Response regulator receiver domain; Region: Response_reg; pfam00072 56107015035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107015036 active site 56107015037 phosphorylation site [posttranslational modification] 56107015038 intermolecular recognition site; other site 56107015039 dimerization interface [polypeptide binding]; other site 56107015040 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 56107015041 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 56107015042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107015043 active site 56107015044 phosphorylation site [posttranslational modification] 56107015045 intermolecular recognition site; other site 56107015046 dimerization interface [polypeptide binding]; other site 56107015047 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 56107015048 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 56107015049 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 56107015050 Ligand Binding Site [chemical binding]; other site 56107015051 cytochrome c biogenesis protein; Region: ccsA; CHL00045 56107015052 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 56107015053 Protein of unknown function (DUF98); Region: DUF98; pfam01947 56107015054 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 56107015055 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 56107015056 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 56107015057 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 56107015058 Predicted integral membrane protein [Function unknown]; Region: COG0762 56107015059 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 56107015060 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 56107015061 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 56107015062 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 56107015063 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 56107015064 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 56107015065 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 56107015066 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 56107015067 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 56107015068 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 56107015069 CHAT domain; Region: CHAT; cl17868 56107015070 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 56107015071 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 56107015072 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 56107015073 DNA binding residues [nucleotide binding] 56107015074 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 56107015075 catalytic residues [active] 56107015076 catalytic nucleophile [active] 56107015077 Probable transposase; Region: OrfB_IS605; pfam01385 56107015078 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 56107015079 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 56107015080 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 56107015081 active site 56107015082 DNA binding site [nucleotide binding] 56107015083 Int/Topo IB signature motif; other site 56107015084 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 56107015085 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 56107015086 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 56107015087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107015088 ribosome recycling factor; Reviewed; Region: frr; PRK00083 56107015089 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 56107015090 hinge region; other site 56107015091 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 56107015092 putative nucleotide binding site [chemical binding]; other site 56107015093 uridine monophosphate binding site [chemical binding]; other site 56107015094 homohexameric interface [polypeptide binding]; other site 56107015095 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 56107015096 putative catalytic residue [active] 56107015097 hydrolase, alpha/beta fold family protein; Region: PLN02824 56107015098 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 56107015099 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 56107015100 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 56107015101 putative active site [active] 56107015102 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 56107015103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107015104 Walker A/P-loop; other site 56107015105 ATP binding site [chemical binding]; other site 56107015106 Q-loop/lid; other site 56107015107 ABC transporter signature motif; other site 56107015108 Walker B; other site 56107015109 D-loop; other site 56107015110 H-loop/switch region; other site 56107015111 HlyD family secretion protein; Region: HlyD; pfam00529 56107015112 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 56107015113 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107015114 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 56107015115 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 56107015116 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 56107015117 Haemolytic domain; Region: Haemolytic; pfam01809 56107015118 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 56107015119 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 56107015120 Response regulator receiver domain; Region: Response_reg; pfam00072 56107015121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107015122 active site 56107015123 phosphorylation site [posttranslational modification] 56107015124 intermolecular recognition site; other site 56107015125 dimerization interface [polypeptide binding]; other site 56107015126 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 56107015127 DNA binding residues [nucleotide binding] 56107015128 GTPase Era; Reviewed; Region: era; PRK00089 56107015129 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 56107015130 G1 box; other site 56107015131 GTP/Mg2+ binding site [chemical binding]; other site 56107015132 Switch I region; other site 56107015133 G2 box; other site 56107015134 Switch II region; other site 56107015135 G3 box; other site 56107015136 G4 box; other site 56107015137 G5 box; other site 56107015138 KH domain; Region: KH_2; pfam07650 56107015139 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 56107015140 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 56107015141 active site 56107015142 Zn binding site [ion binding]; other site 56107015143 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 56107015144 catalytic core [active] 56107015145 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 56107015146 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 56107015147 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 56107015148 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 56107015149 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 56107015150 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 56107015151 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 56107015152 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 56107015153 substrate binding pocket [chemical binding]; other site 56107015154 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 56107015155 B12 binding site [chemical binding]; other site 56107015156 cobalt ligand [ion binding]; other site 56107015157 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 56107015158 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 56107015159 amidase catalytic site [active] 56107015160 Zn binding residues [ion binding]; other site 56107015161 substrate binding site [chemical binding]; other site 56107015162 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 56107015163 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 56107015164 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 56107015165 dimerization interface [polypeptide binding]; other site 56107015166 active site 56107015167 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 56107015168 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 56107015169 enolase; Provisional; Region: eno; PRK00077 56107015170 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 56107015171 dimer interface [polypeptide binding]; other site 56107015172 metal binding site [ion binding]; metal-binding site 56107015173 substrate binding pocket [chemical binding]; other site 56107015174 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 56107015175 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 56107015176 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 56107015177 YcfA-like protein; Region: YcfA; pfam07927 56107015178 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 56107015179 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 56107015180 dimer interface [polypeptide binding]; other site 56107015181 active site 56107015182 metal binding site [ion binding]; metal-binding site 56107015183 glutathione binding site [chemical binding]; other site 56107015184 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 56107015185 Clp amino terminal domain; Region: Clp_N; pfam02861 56107015186 Clp amino terminal domain; Region: Clp_N; pfam02861 56107015187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107015188 Walker A motif; other site 56107015189 ATP binding site [chemical binding]; other site 56107015190 Walker B motif; other site 56107015191 arginine finger; other site 56107015192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107015193 Walker A motif; other site 56107015194 ATP binding site [chemical binding]; other site 56107015195 Walker B motif; other site 56107015196 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 56107015197 Acyltransferase family; Region: Acyl_transf_3; pfam01757 56107015198 Methyltransferase domain; Region: Methyltransf_23; pfam13489 56107015199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107015200 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107015201 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107015202 active site 56107015203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 56107015204 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 56107015205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 56107015206 active site 56107015207 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107015208 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107015209 heat shock protein 90; Provisional; Region: PRK05218 56107015210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107015211 ATP binding site [chemical binding]; other site 56107015212 Mg2+ binding site [ion binding]; other site 56107015213 G-X-G motif; other site 56107015214 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 56107015215 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 56107015216 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 56107015217 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 56107015218 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 56107015219 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107015220 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107015221 active site 56107015222 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 56107015223 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 56107015224 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 56107015225 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 56107015226 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 56107015227 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107015228 putative metal binding site; other site 56107015229 Uncharacterized conserved protein [Function unknown]; Region: COG2928 56107015230 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 56107015231 putative RNA binding site [nucleotide binding]; other site 56107015232 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 56107015233 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 56107015234 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 56107015235 P loop; other site 56107015236 GTP binding site [chemical binding]; other site 56107015237 GAF domain; Region: GAF_3; pfam13492 56107015238 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 56107015239 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 56107015240 PsbP; Region: PsbP; pfam01789 56107015241 Maf-like protein; Region: Maf; pfam02545 56107015242 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 56107015243 active site 56107015244 dimer interface [polypeptide binding]; other site 56107015245 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 56107015246 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 56107015247 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 56107015248 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 56107015249 HlyD family secretion protein; Region: HlyD_3; pfam13437 56107015250 DevC protein; Region: devC; TIGR01185 56107015251 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 56107015252 FtsX-like permease family; Region: FtsX; pfam02687 56107015253 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 56107015254 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 56107015255 Walker A/P-loop; other site 56107015256 ATP binding site [chemical binding]; other site 56107015257 Q-loop/lid; other site 56107015258 ABC transporter signature motif; other site 56107015259 Walker B; other site 56107015260 D-loop; other site 56107015261 H-loop/switch region; other site 56107015262 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 56107015263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107015264 active site 56107015265 motif I; other site 56107015266 motif II; other site 56107015267 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 56107015268 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 56107015269 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 56107015270 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 56107015271 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 56107015272 Malic enzyme, N-terminal domain; Region: malic; pfam00390 56107015273 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 56107015274 putative NAD(P) binding site [chemical binding]; other site 56107015275 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 56107015276 protein I interface; other site 56107015277 D2 interface; other site 56107015278 protein T interface; other site 56107015279 chlorophyll binding site; other site 56107015280 beta carotene binding site; other site 56107015281 pheophytin binding site; other site 56107015282 manganese-stabilizing polypeptide interface; other site 56107015283 CP43 interface; other site 56107015284 protein L interface; other site 56107015285 oxygen evolving complex binding site; other site 56107015286 bromide binding site; other site 56107015287 quinone binding site; other site 56107015288 Fe binding site [ion binding]; other site 56107015289 core light harvesting interface; other site 56107015290 cytochrome b559 alpha subunit interface; other site 56107015291 cytochrome c-550 interface; other site 56107015292 protein J interface; other site 56107015293 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 56107015294 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 56107015295 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 56107015296 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2); Region: LEAP-2; pfam07359 56107015297 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 56107015298 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 56107015299 nudix motif; other site 56107015300 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 56107015301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107015302 TPR motif; other site 56107015303 binding surface 56107015304 Tetratricopeptide repeat; Region: TPR_16; pfam13432 56107015305 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 56107015306 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 56107015307 Walker A/P-loop; other site 56107015308 ATP binding site [chemical binding]; other site 56107015309 Q-loop/lid; other site 56107015310 ABC transporter signature motif; other site 56107015311 Walker B; other site 56107015312 D-loop; other site 56107015313 H-loop/switch region; other site 56107015314 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 56107015315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107015316 S-adenosylmethionine binding site [chemical binding]; other site 56107015317 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 56107015318 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 56107015319 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 56107015320 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 56107015321 isocitrate dehydrogenase; Validated; Region: PRK07362 56107015322 GUN4-like; Region: GUN4; pfam05419 56107015323 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 56107015324 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 56107015325 Walker A/P-loop; other site 56107015326 ATP binding site [chemical binding]; other site 56107015327 Q-loop/lid; other site 56107015328 ABC transporter signature motif; other site 56107015329 Walker B; other site 56107015330 D-loop; other site 56107015331 H-loop/switch region; other site 56107015332 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 56107015333 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 56107015334 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 56107015335 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 56107015336 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 56107015337 Ligand Binding Site [chemical binding]; other site 56107015338 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 56107015339 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 56107015340 TPP-binding site; other site 56107015341 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 56107015342 PYR/PP interface [polypeptide binding]; other site 56107015343 dimer interface [polypeptide binding]; other site 56107015344 TPP binding site [chemical binding]; other site 56107015345 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 56107015346 S-layer homology domain; Region: SLH; pfam00395 56107015347 S-layer homology domain; Region: SLH; pfam00395 56107015348 Archaeal ATPase; Region: Arch_ATPase; pfam01637 56107015349 HEAT repeats; Region: HEAT_2; pfam13646 56107015350 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 56107015351 protein binding surface [polypeptide binding]; other site 56107015352 HEAT repeats; Region: HEAT_2; pfam13646 56107015353 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 56107015354 HEAT-like repeat; Region: HEAT_EZ; pfam13513 56107015355 protein binding surface [polypeptide binding]; other site 56107015356 HEAT repeats; Region: HEAT_2; pfam13646 56107015357 HEAT repeats; Region: HEAT_2; pfam13646 56107015358 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 56107015359 tetramer (dimer of dimers) interface [polypeptide binding]; other site 56107015360 active site 56107015361 dimer interface [polypeptide binding]; other site 56107015362 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 56107015363 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 56107015364 active site 56107015365 catalytic tetrad [active] 56107015366 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 56107015367 Domain of unknown function DUF21; Region: DUF21; pfam01595 56107015368 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 56107015369 Transporter associated domain; Region: CorC_HlyC; smart01091 56107015370 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 56107015371 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 56107015372 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107015373 ATP binding site [chemical binding]; other site 56107015374 putative Mg++ binding site [ion binding]; other site 56107015375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107015376 nucleotide binding region [chemical binding]; other site 56107015377 ATP-binding site [chemical binding]; other site 56107015378 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 56107015379 YcfA-like protein; Region: YcfA; cl00752 56107015380 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 56107015381 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107015382 putative active site [active] 56107015383 Protein of unknown function (DUF433); Region: DUF433; pfam04255 56107015384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 56107015385 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 56107015386 HicB family; Region: HicB; pfam05534 56107015387 FOG: CBS domain [General function prediction only]; Region: COG0517 56107015388 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 56107015389 CP12 domain; Region: CP12; pfam02672 56107015390 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 56107015391 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107015392 active site 56107015393 ATP binding site [chemical binding]; other site 56107015394 substrate binding site [chemical binding]; other site 56107015395 activation loop (A-loop); other site 56107015396 Predicted permeases [General function prediction only]; Region: COG0795 56107015397 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 56107015398 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 56107015399 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 56107015400 Walker A/P-loop; other site 56107015401 ATP binding site [chemical binding]; other site 56107015402 Q-loop/lid; other site 56107015403 ABC transporter signature motif; other site 56107015404 Walker B; other site 56107015405 D-loop; other site 56107015406 H-loop/switch region; other site 56107015407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 56107015408 OstA-like protein; Region: OstA; pfam03968 56107015409 Domain of unknown function (DUF309); Region: DUF309; pfam03745 56107015410 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 56107015411 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 56107015412 Protein of unknown function DUF58; Region: DUF58; pfam01882 56107015413 Protein of unknown function (DUF433); Region: DUF433; pfam04255 56107015414 Domain of unknown function DUF29; Region: DUF29; pfam01724 56107015415 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 56107015416 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 56107015417 G1 box; other site 56107015418 putative GEF interaction site [polypeptide binding]; other site 56107015419 GTP/Mg2+ binding site [chemical binding]; other site 56107015420 Switch I region; other site 56107015421 G2 box; other site 56107015422 G3 box; other site 56107015423 Switch II region; other site 56107015424 G4 box; other site 56107015425 G5 box; other site 56107015426 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 56107015427 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 56107015428 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107015429 non-specific DNA binding site [nucleotide binding]; other site 56107015430 salt bridge; other site 56107015431 sequence-specific DNA binding site [nucleotide binding]; other site 56107015432 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107015433 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107015434 active site 56107015435 ATP binding site [chemical binding]; other site 56107015436 substrate binding site [chemical binding]; other site 56107015437 activation loop (A-loop); other site 56107015438 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 56107015439 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 56107015440 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 56107015441 HD domain; Region: HD_4; pfam13328 56107015442 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 56107015443 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 56107015444 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 56107015445 active site 56107015446 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 56107015447 Catalytic domain of Protein Kinases; Region: PKc; cd00180 56107015448 active site 56107015449 ATP binding site [chemical binding]; other site 56107015450 substrate binding site [chemical binding]; other site 56107015451 activation loop (A-loop); other site 56107015452 AAA domain; Region: AAA_26; pfam13500 56107015453 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 56107015454 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 56107015455 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 56107015456 metal binding site [ion binding]; metal-binding site 56107015457 dimer interface [polypeptide binding]; other site 56107015458 Uncharacterized conserved protein [Function unknown]; Region: COG1543 56107015459 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 56107015460 active site 56107015461 substrate binding site [chemical binding]; other site 56107015462 catalytic site [active] 56107015463 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 56107015464 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 56107015465 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015466 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107015467 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015468 MAPEG family; Region: MAPEG; pfam01124 56107015469 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 56107015470 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 56107015471 substrate binding site [chemical binding]; other site 56107015472 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 56107015473 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 56107015474 substrate binding site [chemical binding]; other site 56107015475 ligand binding site [chemical binding]; other site 56107015476 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 56107015477 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 56107015478 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 56107015479 homodimer interface [polypeptide binding]; other site 56107015480 metal binding site [ion binding]; metal-binding site 56107015481 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 56107015482 homodimer interface [polypeptide binding]; other site 56107015483 active site 56107015484 putative chemical substrate binding site [chemical binding]; other site 56107015485 metal binding site [ion binding]; metal-binding site 56107015486 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 56107015487 Cytochrome P450; Region: p450; cl12078 56107015488 Domain of unknown function (DUF202); Region: DUF202; pfam02656 56107015489 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 56107015490 Sulfatase; Region: Sulfatase; pfam00884 56107015491 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107015492 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 56107015493 Ion channel; Region: Ion_trans_2; pfam07885 56107015494 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107015495 membrane-bound complex binding site; other site 56107015496 hinge residues; other site 56107015497 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 56107015498 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 56107015499 NAD(P) binding site [chemical binding]; other site 56107015500 catalytic residues [active] 56107015501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107015502 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 56107015503 Walker A motif; other site 56107015504 ATP binding site [chemical binding]; other site 56107015505 Walker B motif; other site 56107015506 HEAT repeats; Region: HEAT_2; pfam13646 56107015507 HEAT repeats; Region: HEAT_2; pfam13646 56107015508 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 56107015509 HEAT repeats; Region: HEAT_2; pfam13646 56107015510 HEAT repeats; Region: HEAT_2; pfam13646 56107015511 HEAT repeats; Region: HEAT_2; pfam13646 56107015512 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 56107015513 Peptidase family M48; Region: Peptidase_M48; cl12018 56107015514 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 56107015515 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 56107015516 putative catalytic cysteine [active] 56107015517 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 56107015518 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 56107015519 chorismate binding enzyme; Region: Chorismate_bind; cl10555 56107015520 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 56107015521 UbiA prenyltransferase family; Region: UbiA; pfam01040 56107015522 O-succinylbenzoate synthase; Provisional; Region: PRK02714 56107015523 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 56107015524 active site 56107015525 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 56107015526 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 56107015527 acyl-activating enzyme (AAE) consensus motif; other site 56107015528 putative AMP binding site [chemical binding]; other site 56107015529 putative active site [active] 56107015530 putative CoA binding site [chemical binding]; other site 56107015531 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 56107015532 active site 56107015533 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107015534 putative active site [active] 56107015535 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107015536 putative active site [active] 56107015537 Phosphotransferase enzyme family; Region: APH; pfam01636 56107015538 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 56107015539 active site 56107015540 substrate binding site [chemical binding]; other site 56107015541 ATP binding site [chemical binding]; other site 56107015542 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 56107015543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107015544 Walker A motif; other site 56107015545 ATP binding site [chemical binding]; other site 56107015546 Walker B motif; other site 56107015547 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 56107015548 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 56107015549 AAA ATPase domain; Region: AAA_16; pfam13191 56107015550 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 56107015551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107015552 putative Mg++ binding site [ion binding]; other site 56107015553 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107015554 nucleotide binding region [chemical binding]; other site 56107015555 ATP-binding site [chemical binding]; other site 56107015556 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 56107015557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 56107015558 Restriction endonuclease; Region: Mrr_cat; pfam04471 56107015559 AAA domain; Region: AAA_31; pfam13614 56107015560 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107015561 P-loop; other site 56107015562 Magnesium ion binding site [ion binding]; other site 56107015563 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 56107015564 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 56107015565 putative active site [active] 56107015566 putative metal binding site [ion binding]; other site 56107015567 phosphodiesterase YaeI; Provisional; Region: PRK11340 56107015568 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 56107015569 putative active site [active] 56107015570 putative metal binding site [ion binding]; other site 56107015571 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 56107015572 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107015573 HSP70 interaction site [polypeptide binding]; other site 56107015574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107015575 TPR repeat; Region: TPR_11; pfam13414 56107015576 binding surface 56107015577 TPR motif; other site 56107015578 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107015579 structural tetrad; other site 56107015580 PQQ-like domain; Region: PQQ_2; pfam13360 56107015581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107015582 Probable transposase; Region: OrfB_IS605; pfam01385 56107015583 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 56107015584 Uncharacterized conserved protein [Function unknown]; Region: COG1434 56107015585 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 56107015586 putative active site [active] 56107015587 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 56107015588 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 56107015589 active site 56107015590 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 56107015591 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 56107015592 catalytic residues [active] 56107015593 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 56107015594 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 56107015595 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 56107015596 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 56107015597 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 56107015598 Uncharacterized conserved protein [Function unknown]; Region: COG1432 56107015599 LabA_like proteins; Region: LabA; cd10911 56107015600 putative metal binding site [ion binding]; other site 56107015601 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 56107015602 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 56107015603 active site 56107015604 HIGH motif; other site 56107015605 KMSKS motif; other site 56107015606 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 56107015607 anticodon binding site; other site 56107015608 tRNA binding surface [nucleotide binding]; other site 56107015609 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 56107015610 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 56107015611 putative acyl-acceptor binding pocket; other site 56107015612 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 56107015613 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 56107015614 multifunctional aminopeptidase A; Provisional; Region: PRK00913 56107015615 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 56107015616 interface (dimer of trimers) [polypeptide binding]; other site 56107015617 Substrate-binding/catalytic site; other site 56107015618 Zn-binding sites [ion binding]; other site 56107015619 putative phosphate acyltransferase; Provisional; Region: PRK05331 56107015620 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 56107015621 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 56107015622 dimer interface [polypeptide binding]; other site 56107015623 active site 56107015624 CoA binding pocket [chemical binding]; other site 56107015625 RRXRR protein; Region: RRXRR; pfam14239 56107015626 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107015627 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107015628 active site 56107015629 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 56107015630 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107015631 PBP superfamily domain; Region: PBP_like_2; cl17296 56107015632 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 56107015633 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 56107015634 putative acyl-acceptor binding pocket; other site 56107015635 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 56107015636 Domain of unknown function DUF20; Region: UPF0118; pfam01594 56107015637 Uncharacterized small conserved protein [Function unknown]; Region: COG5626 56107015638 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 56107015639 MutS domain III; Region: MutS_III; pfam05192 56107015640 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107015641 Walker A/P-loop; other site 56107015642 ATP binding site [chemical binding]; other site 56107015643 Q-loop/lid; other site 56107015644 ABC transporter signature motif; other site 56107015645 Walker B; other site 56107015646 D-loop; other site 56107015647 H-loop/switch region; other site 56107015648 Smr domain; Region: Smr; pfam01713 56107015649 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 56107015650 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 56107015651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4298 56107015652 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 56107015653 Ycf35; Provisional; Region: ycf35; CHL00193 56107015654 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 56107015655 M28 Zn-Peptidases; Region: M28_like_1; cd05640 56107015656 Peptidase family M28; Region: Peptidase_M28; pfam04389 56107015657 metal binding site [ion binding]; metal-binding site 56107015658 Uncharacterized conserved protein [Function unknown]; Region: COG2442 56107015659 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 56107015660 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 56107015661 XisI protein; Region: XisI; pfam08869 56107015662 XisH protein; Region: XisH; pfam08814 56107015663 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 56107015664 NAD(P) binding pocket [chemical binding]; other site 56107015665 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 56107015666 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 56107015667 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 56107015668 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 56107015669 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 56107015670 Walker A motif; other site 56107015671 ATP binding site [chemical binding]; other site 56107015672 Walker B motif; other site 56107015673 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 56107015674 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 56107015675 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 56107015676 Walker A motif; other site 56107015677 ATP binding site [chemical binding]; other site 56107015678 Walker B motif; other site 56107015679 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 56107015680 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 56107015681 dimer interface [polypeptide binding]; other site 56107015682 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 56107015683 molecular chaperone DnaK; Provisional; Region: PRK13411 56107015684 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 56107015685 nucleotide binding site [chemical binding]; other site 56107015686 NEF interaction site [polypeptide binding]; other site 56107015687 SBD interface [polypeptide binding]; other site 56107015688 chaperone protein DnaJ; Provisional; Region: PRK14293 56107015689 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107015690 HSP70 interaction site [polypeptide binding]; other site 56107015691 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 56107015692 Zn binding sites [ion binding]; other site 56107015693 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 56107015694 dimer interface [polypeptide binding]; other site 56107015695 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 56107015696 CPxP motif; other site 56107015697 GTPase RsgA; Reviewed; Region: PRK12289 56107015698 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 56107015699 RNA binding site [nucleotide binding]; other site 56107015700 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 56107015701 GTPase/Zn-binding domain interface [polypeptide binding]; other site 56107015702 GTP/Mg2+ binding site [chemical binding]; other site 56107015703 G4 box; other site 56107015704 G5 box; other site 56107015705 G1 box; other site 56107015706 Switch I region; other site 56107015707 G2 box; other site 56107015708 G3 box; other site 56107015709 Switch II region; other site 56107015710 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015711 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015712 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107015713 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015714 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015715 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107015716 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015717 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015718 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015719 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015720 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015721 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015722 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107015723 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015724 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015725 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015726 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 56107015727 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 56107015728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107015729 Probable transposase; Region: OrfB_IS605; pfam01385 56107015730 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107015731 haemagglutination activity domain; Region: Haemagg_act; cl05436 56107015732 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 56107015733 Fasciclin domain; Region: Fasciclin; pfam02469 56107015734 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 56107015735 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348 56107015736 putative ligand binding site [chemical binding]; other site 56107015737 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 56107015738 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 56107015739 TM-ABC transporter signature motif; other site 56107015740 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 56107015741 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 56107015742 TM-ABC transporter signature motif; other site 56107015743 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 56107015744 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 56107015745 Walker A/P-loop; other site 56107015746 ATP binding site [chemical binding]; other site 56107015747 Q-loop/lid; other site 56107015748 ABC transporter signature motif; other site 56107015749 Walker B; other site 56107015750 D-loop; other site 56107015751 H-loop/switch region; other site 56107015752 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 56107015753 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 56107015754 Walker A/P-loop; other site 56107015755 ATP binding site [chemical binding]; other site 56107015756 Q-loop/lid; other site 56107015757 ABC transporter signature motif; other site 56107015758 Walker B; other site 56107015759 D-loop; other site 56107015760 H-loop/switch region; other site 56107015761 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 56107015762 catalytic core [active] 56107015763 glucokinase; Provisional; Region: glk; PRK00292 56107015764 glucokinase, proteobacterial type; Region: glk; TIGR00749 56107015765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107015766 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107015767 Probable transposase; Region: OrfB_IS605; pfam01385 56107015768 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 56107015769 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 56107015770 DNA binding residues [nucleotide binding] 56107015771 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 56107015772 catalytic residues [active] 56107015773 catalytic nucleophile [active] 56107015774 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 56107015775 Uncharacterized conserved protein [Function unknown]; Region: COG1262 56107015776 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 56107015777 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 56107015778 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 56107015779 hypothetical protein; Validated; Region: PRK00110 56107015780 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 56107015781 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 56107015782 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 56107015783 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 56107015784 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 56107015785 N-acetyl-D-glucosamine binding site [chemical binding]; other site 56107015786 catalytic residue [active] 56107015787 AAA ATPase domain; Region: AAA_16; pfam13191 56107015788 WD domain, G-beta repeat; Region: WD40; pfam00400 56107015789 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107015790 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107015791 structural tetrad; other site 56107015792 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107015793 structural tetrad; other site 56107015794 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 56107015795 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 56107015796 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 56107015797 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 56107015798 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 56107015799 cytochrome b subunit interaction site [polypeptide binding]; other site 56107015800 [2Fe-2S] cluster binding site [ion binding]; other site 56107015801 apocytochrome f; Reviewed; Region: PRK02693 56107015802 cytochrome f; Region: petA; CHL00037 56107015803 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 56107015804 Phosphate acyltransferases; Region: PlsC; smart00563 56107015805 putative acyl-acceptor binding pocket; other site 56107015806 Protein of unknown function (DUF938); Region: DUF938; pfam06080 56107015807 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 56107015808 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 56107015809 active site residue [active] 56107015810 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 56107015811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107015812 S-adenosylmethionine binding site [chemical binding]; other site 56107015813 phosphoribulokinase; Provisional; Region: PRK07429 56107015814 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 56107015815 active site 56107015816 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 56107015817 hypothetical protein; Reviewed; Region: PRK00024 56107015818 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 56107015819 MPN+ (JAMM) motif; other site 56107015820 Zinc-binding site [ion binding]; other site 56107015821 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 56107015822 G1 box; other site 56107015823 GTP/Mg2+ binding site [chemical binding]; other site 56107015824 G2 box; other site 56107015825 Switch I region; other site 56107015826 G3 box; other site 56107015827 Switch II region; other site 56107015828 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 56107015829 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 56107015830 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 56107015831 Protein of unknown function (DUF497); Region: DUF497; cl01108 56107015832 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 56107015833 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 56107015834 Protein of unknown function (DUF433); Region: DUF433; pfam04255 56107015835 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 56107015836 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 56107015837 active site 56107015838 catalytic tetrad [active] 56107015839 RloB-like protein; Region: RloB; pfam13707 56107015840 AAA domain; Region: AAA_21; pfam13304 56107015841 Predicted GTPase [General function prediction only]; Region: COG3596 56107015842 YfjP GTPase; Region: YfjP; cd11383 56107015843 G1 box; other site 56107015844 GTP/Mg2+ binding site [chemical binding]; other site 56107015845 Switch I region; other site 56107015846 G2 box; other site 56107015847 Switch II region; other site 56107015848 G3 box; other site 56107015849 G4 box; other site 56107015850 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 56107015851 Chain length determinant protein; Region: Wzz; pfam02706 56107015852 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 56107015853 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107015854 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 56107015855 putative hexamer interface [polypeptide binding]; other site 56107015856 putative hexagonal pore; other site 56107015857 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 56107015858 Hexamer interface [polypeptide binding]; other site 56107015859 Hexagonal pore residue; other site 56107015860 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107015861 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015862 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015863 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015864 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015865 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015866 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107015867 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 56107015868 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 56107015869 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 56107015870 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 56107015871 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 56107015872 Walker A/P-loop; other site 56107015873 ATP binding site [chemical binding]; other site 56107015874 Q-loop/lid; other site 56107015875 ABC transporter signature motif; other site 56107015876 Walker B; other site 56107015877 D-loop; other site 56107015878 H-loop/switch region; other site 56107015879 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 56107015880 putative carbohydrate binding site [chemical binding]; other site 56107015881 Methyltransferase domain; Region: Methyltransf_23; pfam13489 56107015882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107015883 S-adenosylmethionine binding site [chemical binding]; other site 56107015884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 56107015885 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 56107015886 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107015887 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107015888 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 56107015889 metal-binding site 56107015890 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107015891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 56107015892 active site 56107015893 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 56107015894 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107015895 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 56107015896 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 56107015897 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107015898 Methyltransferase domain; Region: Methyltransf_23; pfam13489 56107015899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107015900 S-adenosylmethionine binding site [chemical binding]; other site 56107015901 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 56107015902 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 56107015903 active site 56107015904 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107015905 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107015906 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 56107015907 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 56107015908 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 56107015909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107015910 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107015911 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 56107015912 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107015913 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 56107015914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107015915 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 56107015916 putative ADP-binding pocket [chemical binding]; other site 56107015917 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 56107015918 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 56107015919 active site 56107015920 dimer interface [polypeptide binding]; other site 56107015921 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 56107015922 Ligand Binding Site [chemical binding]; other site 56107015923 Molecular Tunnel; other site 56107015924 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107015925 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 56107015926 putative ADP-binding pocket [chemical binding]; other site 56107015927 Methyltransferase domain; Region: Methyltransf_23; pfam13489 56107015928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107015929 S-adenosylmethionine binding site [chemical binding]; other site 56107015930 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 56107015931 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 56107015932 putative metal binding site; other site 56107015933 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 56107015934 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 56107015935 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 56107015936 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 56107015937 Acyltransferase family; Region: Acyl_transf_3; pfam01757 56107015938 Uncharacterized conserved protein [Function unknown]; Region: COG1434 56107015939 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 56107015940 putative active site [active] 56107015941 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015942 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107015943 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107015944 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 56107015945 ATP-grasp domain; Region: ATP-grasp; pfam02222 56107015946 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 56107015947 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 56107015948 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 56107015949 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 56107015950 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 56107015951 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 56107015952 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107015953 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107015954 Predicted membrane protein [Function unknown]; Region: COG1950 56107015955 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 56107015956 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 56107015957 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 56107015958 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 56107015959 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 56107015960 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 56107015961 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 56107015962 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 56107015963 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 56107015964 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 56107015965 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 56107015966 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 56107015967 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 56107015968 GAF domain; Region: GAF; pfam01590 56107015969 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 56107015970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107015971 dimer interface [polypeptide binding]; other site 56107015972 phosphorylation site [posttranslational modification] 56107015973 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 56107015974 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 56107015975 inhibitor-cofactor binding pocket; inhibition site 56107015976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107015977 catalytic residue [active] 56107015978 cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156 56107015979 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 56107015980 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 56107015981 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 56107015982 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 56107015983 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 56107015984 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 56107015985 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107015986 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 56107015987 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 56107015988 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 56107015989 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 56107015990 substrate binding site; other site 56107015991 tetramer interface; other site 56107015992 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 56107015993 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 56107015994 NAD binding site [chemical binding]; other site 56107015995 substrate binding site [chemical binding]; other site 56107015996 homodimer interface [polypeptide binding]; other site 56107015997 active site 56107015998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 56107015999 binding surface 56107016000 TPR motif; other site 56107016001 excinuclease ABC subunit B; Provisional; Region: PRK05298 56107016002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107016003 ATP binding site [chemical binding]; other site 56107016004 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107016005 nucleotide binding region [chemical binding]; other site 56107016006 ATP-binding site [chemical binding]; other site 56107016007 Ultra-violet resistance protein B; Region: UvrB; pfam12344 56107016008 CsbD-like; Region: CsbD; pfam05532 56107016009 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 56107016010 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 56107016011 substrate binding site [chemical binding]; other site 56107016012 hexamer interface [polypeptide binding]; other site 56107016013 metal binding site [ion binding]; metal-binding site 56107016014 Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488 56107016015 putative catalytic residues [active] 56107016016 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 56107016017 putative active site [active] 56107016018 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 56107016019 Domain of unknown function DUF20; Region: UPF0118; pfam01594 56107016020 Transcriptional regulator [Transcription]; Region: LytR; COG1316 56107016021 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 56107016022 Uncharacterized conserved protein [Function unknown]; Region: COG2442 56107016023 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 56107016024 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 56107016025 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 56107016026 active site 56107016027 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 56107016028 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 56107016029 active site 56107016030 (T/H)XGH motif; other site 56107016031 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 56107016032 nudix motif; other site 56107016033 NAD synthetase; Provisional; Region: PRK13981 56107016034 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 56107016035 multimer interface [polypeptide binding]; other site 56107016036 active site 56107016037 catalytic triad [active] 56107016038 protein interface 1 [polypeptide binding]; other site 56107016039 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 56107016040 homodimer interface [polypeptide binding]; other site 56107016041 NAD binding pocket [chemical binding]; other site 56107016042 ATP binding pocket [chemical binding]; other site 56107016043 Mg binding site [ion binding]; other site 56107016044 active-site loop [active] 56107016045 TPR repeat; Region: TPR_11; pfam13414 56107016046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107016047 binding surface 56107016048 TPR motif; other site 56107016049 TPR repeat; Region: TPR_11; pfam13414 56107016050 Uncharacterized conserved protein [Function unknown]; Region: COG0393 56107016051 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 56107016052 substrate binding site [chemical binding]; other site 56107016053 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107016054 Probable transposase; Region: OrfB_IS605; pfam01385 56107016055 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107016056 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 56107016057 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 56107016058 putative DNA binding site [nucleotide binding]; other site 56107016059 putative Zn2+ binding site [ion binding]; other site 56107016060 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 56107016061 putative ABC transporter; Region: ycf24; CHL00085 56107016062 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 56107016063 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 56107016064 Walker A/P-loop; other site 56107016065 ATP binding site [chemical binding]; other site 56107016066 Q-loop/lid; other site 56107016067 ABC transporter signature motif; other site 56107016068 Walker B; other site 56107016069 D-loop; other site 56107016070 H-loop/switch region; other site 56107016071 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 56107016072 FeS assembly protein SufD; Region: sufD; TIGR01981 56107016073 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 56107016074 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 56107016075 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 56107016076 catalytic residue [active] 56107016077 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107016078 putative active site [active] 56107016079 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107016080 putative active site [active] 56107016081 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 56107016082 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 56107016083 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 56107016084 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 56107016085 metal-binding site [ion binding] 56107016086 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 56107016087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107016088 motif II; other site 56107016089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 56107016090 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 56107016091 phosphopeptide binding site; other site 56107016092 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 56107016093 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 56107016094 putative NAD(P) binding site [chemical binding]; other site 56107016095 putative active site [active] 56107016096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107016097 binding surface 56107016098 TPR motif; other site 56107016099 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 56107016100 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 56107016101 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 56107016102 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107016103 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 56107016104 putative hydrophobic ligand binding site [chemical binding]; other site 56107016105 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107016106 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 56107016107 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 56107016108 Lipoxygenase; Region: Lipoxygenase; pfam00305 56107016109 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 56107016110 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 56107016111 catalytic loop [active] 56107016112 iron binding site [ion binding]; other site 56107016113 cobyric acid synthase; Provisional; Region: PRK00784 56107016114 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 56107016115 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 56107016116 catalytic triad [active] 56107016117 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 56107016118 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 56107016119 catalytic triad [active] 56107016120 ABC-2 type transporter; Region: ABC2_membrane; cl17235 56107016121 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 56107016122 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 56107016123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107016124 Walker A/P-loop; other site 56107016125 ATP binding site [chemical binding]; other site 56107016126 Q-loop/lid; other site 56107016127 ABC transporter signature motif; other site 56107016128 Walker B; other site 56107016129 D-loop; other site 56107016130 H-loop/switch region; other site 56107016131 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 56107016132 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 56107016133 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 56107016134 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 56107016135 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 56107016136 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 56107016137 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 56107016138 hexamer interface [polypeptide binding]; other site 56107016139 ligand binding site [chemical binding]; other site 56107016140 putative active site [active] 56107016141 NAD(P) binding site [chemical binding]; other site 56107016142 light-harvesting-like protein 3; Provisional; Region: PLN00014 56107016143 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107016144 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107016145 structural tetrad; other site 56107016146 SET domain; Region: SET; pfam00856 56107016147 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107016148 putative active site [active] 56107016149 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 56107016150 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 56107016151 Subunit I/III interface [polypeptide binding]; other site 56107016152 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 56107016153 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 56107016154 D-pathway; other site 56107016155 Putative ubiquinol binding site [chemical binding]; other site 56107016156 Low-spin heme (heme b) binding site [chemical binding]; other site 56107016157 Putative water exit pathway; other site 56107016158 Binuclear center (heme o3/CuB) [ion binding]; other site 56107016159 K-pathway; other site 56107016160 Putative proton exit pathway; other site 56107016161 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 56107016162 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 56107016163 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 56107016164 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 56107016165 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 56107016166 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 56107016167 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 56107016168 UbiA prenyltransferase family; Region: UbiA; pfam01040 56107016169 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 56107016170 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 56107016171 YcfA-like protein; Region: YcfA; pfam07927 56107016172 Protein of unknown function (DUF433); Region: DUF433; pfam04255 56107016173 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 56107016174 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 56107016175 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 56107016176 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 56107016177 active site 56107016178 nucleotide binding site [chemical binding]; other site 56107016179 HIGH motif; other site 56107016180 KMSKS motif; other site 56107016181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107016182 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107016183 Probable transposase; Region: OrfB_IS605; pfam01385 56107016184 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107016185 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107016186 putative active site [active] 56107016187 gamma-glutamyl kinase; Provisional; Region: PRK05429 56107016188 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 56107016189 nucleotide binding site [chemical binding]; other site 56107016190 homotetrameric interface [polypeptide binding]; other site 56107016191 putative phosphate binding site [ion binding]; other site 56107016192 putative allosteric binding site; other site 56107016193 PUA domain; Region: PUA; pfam01472 56107016194 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 56107016195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107016196 active site 56107016197 motif I; other site 56107016198 motif II; other site 56107016199 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 56107016200 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 56107016201 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 56107016202 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 56107016203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107016204 Coenzyme A binding pocket [chemical binding]; other site 56107016205 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 56107016206 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 56107016207 UbiA prenyltransferase family; Region: UbiA; pfam01040 56107016208 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 56107016209 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 56107016210 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 56107016211 Zn2+ binding site [ion binding]; other site 56107016212 Mg2+ binding site [ion binding]; other site 56107016213 Acyltransferase family; Region: Acyl_transf_3; pfam01757 56107016214 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 56107016215 active site 56107016216 ATP binding site [chemical binding]; other site 56107016217 substrate binding site [chemical binding]; other site 56107016218 activation loop (A-loop); other site 56107016219 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107016220 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107016221 structural tetrad; other site 56107016222 Protein phosphatase 2C; Region: PP2C_2; pfam13672 56107016223 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 56107016224 metal ion-dependent adhesion site (MIDAS); other site 56107016225 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107016226 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107016227 acyl-activating enzyme (AAE) consensus motif; other site 56107016228 AMP binding site [chemical binding]; other site 56107016229 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016230 Condensation domain; Region: Condensation; pfam00668 56107016231 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107016232 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107016233 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107016234 acyl-activating enzyme (AAE) consensus motif; other site 56107016235 AMP binding site [chemical binding]; other site 56107016236 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016237 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 56107016238 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107016239 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107016240 acyl-activating enzyme (AAE) consensus motif; other site 56107016241 AMP binding site [chemical binding]; other site 56107016242 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016243 Cna protein B-type domain; Region: Cna_B; pfam05738 56107016244 Cna protein B-type domain; Region: Cna_B; pfam05738 56107016245 Cna protein B-type domain; Region: Cna_B; pfam05738 56107016246 conserved repeat domain; Region: B_ant_repeat; TIGR01451 56107016247 conserved repeat domain; Region: B_ant_repeat; TIGR01451 56107016248 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 56107016249 EamA-like transporter family; Region: EamA; pfam00892 56107016250 EamA-like transporter family; Region: EamA; pfam00892 56107016251 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107016252 HEAT repeats; Region: HEAT_2; pfam13646 56107016253 HEAT repeats; Region: HEAT_2; pfam13646 56107016254 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 56107016255 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 56107016256 dimer interface [polypeptide binding]; other site 56107016257 catalytic triad [active] 56107016258 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 56107016259 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 56107016260 active site 56107016261 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 56107016262 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 56107016263 putative ADP-binding pocket [chemical binding]; other site 56107016264 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 56107016265 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 56107016266 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 56107016267 nitrilase; Region: PLN02798 56107016268 putative active site [active] 56107016269 catalytic triad [active] 56107016270 dimer interface [polypeptide binding]; other site 56107016271 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 56107016272 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 56107016273 NACHT domain; Region: NACHT; pfam05729 56107016274 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107016275 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107016276 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107016277 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107016278 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107016279 NACHT domain; Region: NACHT; pfam05729 56107016280 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107016281 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107016282 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107016283 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107016284 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 56107016285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107016286 motif II; other site 56107016287 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 56107016288 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 56107016289 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 56107016290 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 56107016291 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 56107016292 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 56107016293 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 56107016294 PLD-like domain; Region: PLDc_2; pfam13091 56107016295 putative active site [active] 56107016296 catalytic site [active] 56107016297 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 56107016298 PLD-like domain; Region: PLDc_2; pfam13091 56107016299 putative active site [active] 56107016300 catalytic site [active] 56107016301 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 56107016302 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 56107016303 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 56107016304 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 56107016305 catalytic residue [active] 56107016306 Protein of unknown function (DUF416); Region: DUF416; cl01166 56107016307 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 56107016308 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 56107016309 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 56107016310 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107016311 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 56107016312 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107016313 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107016314 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 56107016315 putative ADP-ribose binding site [chemical binding]; other site 56107016316 putative active site [active] 56107016317 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 56107016318 proposed catalytic triad [active] 56107016319 active site nucleophile [active] 56107016320 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 56107016321 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 56107016322 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 56107016323 active site 56107016324 non-prolyl cis peptide bond; other site 56107016325 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 56107016326 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 56107016327 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 56107016328 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 56107016329 active site 56107016330 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 56107016331 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 56107016332 dimer interface [polypeptide binding]; other site 56107016333 putative functional site; other site 56107016334 putative MPT binding site; other site 56107016335 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 56107016336 active site 56107016337 NTP binding site [chemical binding]; other site 56107016338 metal binding triad [ion binding]; metal-binding site 56107016339 antibiotic binding site [chemical binding]; other site 56107016340 HEPN domain; Region: HEPN; pfam05168 56107016341 RDD family; Region: RDD; pfam06271 56107016342 ribosomal protein L33; Region: rpl33; CHL00104 56107016343 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 56107016344 Exoribonuclease R [Transcription]; Region: VacB; COG0557 56107016345 RNB domain; Region: RNB; pfam00773 56107016346 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 56107016347 active site 56107016348 catalytic residues [active] 56107016349 metal binding site [ion binding]; metal-binding site 56107016350 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 56107016351 multidrug efflux protein NorA; Provisional; Region: PRK00187 56107016352 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 56107016353 cation binding site [ion binding]; other site 56107016354 Methyltransferase domain; Region: Methyltransf_31; pfam13847 56107016355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107016356 S-adenosylmethionine binding site [chemical binding]; other site 56107016357 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 56107016358 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 56107016359 acyl-activating enzyme (AAE) consensus motif; other site 56107016360 AMP binding site [chemical binding]; other site 56107016361 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016362 Condensation domain; Region: Condensation; pfam00668 56107016363 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107016364 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 56107016365 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 56107016366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 56107016367 catalytic residue [active] 56107016368 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 56107016369 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 56107016370 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 56107016371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 56107016372 catalytic residue [active] 56107016373 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 56107016374 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 56107016375 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 56107016376 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 56107016377 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 56107016378 CRISPR-associated protein; Region: TIGR03986 56107016379 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 56107016380 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 56107016381 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 56107016382 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 56107016383 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 56107016384 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 56107016385 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 56107016386 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 56107016387 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cl09837 56107016388 WYL domain; Region: WYL; cl14852 56107016389 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 56107016390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107016391 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 56107016392 NAD(P) binding site [chemical binding]; other site 56107016393 active site 56107016394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 56107016395 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 56107016396 Probable transposase; Region: OrfB_IS605; pfam01385 56107016397 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 56107016398 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 56107016399 substrate binding site [chemical binding]; other site 56107016400 active site 56107016401 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 56107016402 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 56107016403 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 56107016404 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 56107016405 intersubunit interface [polypeptide binding]; other site 56107016406 active site 56107016407 zinc binding site [ion binding]; other site 56107016408 Na+ binding site [ion binding]; other site 56107016409 tyramine oxidase; Provisional; Region: tynA; PRK11504 56107016410 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 56107016411 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 56107016412 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 56107016413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107016414 binding surface 56107016415 TPR motif; other site 56107016416 TPR repeat; Region: TPR_11; pfam13414 56107016417 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 56107016418 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 56107016419 substrate binding pocket [chemical binding]; other site 56107016420 membrane-bound complex binding site; other site 56107016421 hinge residues; other site 56107016422 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 56107016423 23S rRNA binding site [nucleotide binding]; other site 56107016424 L21 binding site [polypeptide binding]; other site 56107016425 L13 binding site [polypeptide binding]; other site 56107016426 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 56107016427 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 56107016428 Family description; Region: UvrD_C_2; pfam13538 56107016429 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 56107016430 Response regulator receiver domain; Region: Response_reg; pfam00072 56107016431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107016432 active site 56107016433 phosphorylation site [posttranslational modification] 56107016434 intermolecular recognition site; other site 56107016435 dimerization interface [polypeptide binding]; other site 56107016436 GAF domain; Region: GAF; pfam01590 56107016437 GAF domain; Region: GAF_2; pfam13185 56107016438 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 56107016439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107016440 S-adenosylmethionine binding site [chemical binding]; other site 56107016441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 56107016442 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107016443 putative active site [active] 56107016444 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 56107016445 [2Fe-2S] cluster binding site [ion binding]; other site 56107016446 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 56107016447 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 56107016448 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 56107016449 Zn2+ binding site [ion binding]; other site 56107016450 Mg2+ binding site [ion binding]; other site 56107016451 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 56107016452 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 56107016453 Dehydroquinase class II; Region: DHquinase_II; pfam01220 56107016454 trimer interface [polypeptide binding]; other site 56107016455 active site 56107016456 dimer interface [polypeptide binding]; other site 56107016457 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 56107016458 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 56107016459 active site 56107016460 interdomain interaction site; other site 56107016461 putative metal-binding site [ion binding]; other site 56107016462 nucleotide binding site [chemical binding]; other site 56107016463 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 56107016464 domain I; other site 56107016465 phosphate binding site [ion binding]; other site 56107016466 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 56107016467 domain II; other site 56107016468 domain III; other site 56107016469 nucleotide binding site [chemical binding]; other site 56107016470 DNA binding groove [nucleotide binding] 56107016471 catalytic site [active] 56107016472 domain IV; other site 56107016473 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 56107016474 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 56107016475 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 56107016476 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 56107016477 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 56107016478 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 56107016479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 56107016480 dimer interface [polypeptide binding]; other site 56107016481 phosphorylation site [posttranslational modification] 56107016482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107016483 ATP binding site [chemical binding]; other site 56107016484 Mg2+ binding site [ion binding]; other site 56107016485 G-X-G motif; other site 56107016486 Predicted transcriptional regulator [Transcription]; Region: COG2345 56107016487 Response regulator receiver domain; Region: Response_reg; pfam00072 56107016488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107016489 active site 56107016490 phosphorylation site [posttranslational modification] 56107016491 intermolecular recognition site; other site 56107016492 dimerization interface [polypeptide binding]; other site 56107016493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 56107016494 dimer interface [polypeptide binding]; other site 56107016495 phosphorylation site [posttranslational modification] 56107016496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107016497 ATP binding site [chemical binding]; other site 56107016498 Mg2+ binding site [ion binding]; other site 56107016499 G-X-G motif; other site 56107016500 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 56107016501 Fatty acid desaturase; Region: FA_desaturase; pfam00487 56107016502 putative di-iron ligands [ion binding]; other site 56107016503 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 56107016504 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 56107016505 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 56107016506 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 56107016507 dimerization domain swap beta strand [polypeptide binding]; other site 56107016508 regulatory protein interface [polypeptide binding]; other site 56107016509 active site 56107016510 regulatory phosphorylation site [posttranslational modification]; other site 56107016511 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 56107016512 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 56107016513 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 56107016514 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 56107016515 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 56107016516 Mechanosensitive ion channel; Region: MS_channel; pfam00924 56107016517 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 56107016518 Mechanosensitive ion channel; Region: MS_channel; pfam00924 56107016519 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 56107016520 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 56107016521 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 56107016522 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 56107016523 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 56107016524 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 56107016525 active site 56107016526 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 56107016527 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 56107016528 acyl-activating enzyme (AAE) consensus motif; other site 56107016529 AMP binding site [chemical binding]; other site 56107016530 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 56107016531 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 56107016532 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107016533 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 56107016534 active site 56107016535 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107016536 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107016537 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 56107016538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 56107016539 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 56107016540 Enoylreductase; Region: PKS_ER; smart00829 56107016541 NAD(P) binding site [chemical binding]; other site 56107016542 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 56107016543 putative NADP binding site [chemical binding]; other site 56107016544 KR domain; Region: KR; pfam08659 56107016545 active site 56107016546 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107016547 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 56107016548 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107016549 active site 56107016550 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107016551 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 56107016552 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 56107016553 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 56107016554 putative NADP binding site [chemical binding]; other site 56107016555 active site 56107016556 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107016557 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107016558 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 56107016559 active site 56107016560 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107016561 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107016562 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107016563 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 56107016564 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107016565 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 56107016566 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 56107016567 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 56107016568 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 56107016569 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 56107016570 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 56107016571 active site 56107016572 catalytic residues [active] 56107016573 metal binding site [ion binding]; metal-binding site 56107016574 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 56107016575 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 56107016576 protein binding site [polypeptide binding]; other site 56107016577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 56107016578 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107016579 active site 56107016580 catalytic residues [active] 56107016581 DNA binding site [nucleotide binding] 56107016582 Int/Topo IB signature motif; other site 56107016583 Helix-turn-helix domain; Region: HTH_17; pfam12728 56107016584 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 56107016585 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 56107016586 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 56107016587 active site 56107016588 metal binding site [ion binding]; metal-binding site 56107016589 interdomain interaction site; other site 56107016590 Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399 56107016591 Predicted membrane protein [Function unknown]; Region: COG1422 56107016592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107016593 non-specific DNA binding site [nucleotide binding]; other site 56107016594 salt bridge; other site 56107016595 sequence-specific DNA binding site [nucleotide binding]; other site 56107016596 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 56107016597 Clp amino terminal domain; Region: Clp_N; pfam02861 56107016598 Clp amino terminal domain; Region: Clp_N; pfam02861 56107016599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107016600 Walker A motif; other site 56107016601 ATP binding site [chemical binding]; other site 56107016602 Walker B motif; other site 56107016603 arginine finger; other site 56107016604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107016605 Walker A motif; other site 56107016606 ATP binding site [chemical binding]; other site 56107016607 Walker B motif; other site 56107016608 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 56107016609 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 56107016610 chorismate binding enzyme; Region: Chorismate_bind; cl10555 56107016611 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 56107016612 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 56107016613 active site 56107016614 catalytic tetrad [active] 56107016615 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 56107016616 Isochorismatase family; Region: Isochorismatase; pfam00857 56107016617 catalytic triad [active] 56107016618 conserved cis-peptide bond; other site 56107016619 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 56107016620 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 56107016621 Helix-turn-helix domain; Region: HTH_28; pfam13518 56107016622 Integrase core domain; Region: rve; pfam00665 56107016623 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 56107016624 Homeodomain-like domain; Region: HTH_23; pfam13384 56107016625 Winged helix-turn helix; Region: HTH_29; pfam13551 56107016626 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 56107016627 active site 56107016628 Int/Topo IB signature motif; other site 56107016629 DNA binding site [nucleotide binding] 56107016630 Predicted ATPase [General function prediction only]; Region: COG4637 56107016631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107016632 Walker A/P-loop; other site 56107016633 ATP binding site [chemical binding]; other site 56107016634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 56107016635 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 56107016636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107016637 sequence-specific DNA binding site [nucleotide binding]; other site 56107016638 salt bridge; other site 56107016639 TniQ; Region: TniQ; pfam06527 56107016640 AAA domain; Region: AAA_22; pfam13401 56107016641 Integrase core domain; Region: rve; pfam00665 56107016642 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 56107016643 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 56107016644 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 56107016645 active site 56107016646 DNA binding site [nucleotide binding] 56107016647 Int/Topo IB signature motif; other site 56107016648 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 56107016649 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 56107016650 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 56107016651 acyl-activating enzyme (AAE) consensus motif; other site 56107016652 putative AMP binding site [chemical binding]; other site 56107016653 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 56107016654 putative NADP binding site [chemical binding]; other site 56107016655 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 56107016656 active site 56107016657 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016658 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107016659 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 56107016660 active site 56107016661 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107016662 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107016663 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 56107016664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107016665 S-adenosylmethionine binding site [chemical binding]; other site 56107016666 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 56107016667 KR domain; Region: KR; pfam08659 56107016668 putative NADP binding site [chemical binding]; other site 56107016669 active site 56107016670 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107016671 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 56107016672 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 56107016673 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 56107016674 acyl-CoA synthetase; Validated; Region: PRK05850 56107016675 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 56107016676 acyl-activating enzyme (AAE) consensus motif; other site 56107016677 active site 56107016678 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 56107016679 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 56107016680 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107016681 active site 56107016682 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107016683 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016684 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 56107016685 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 56107016686 inhibitor-cofactor binding pocket; inhibition site 56107016687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 56107016688 catalytic residue [active] 56107016689 Condensation domain; Region: Condensation; pfam00668 56107016690 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107016691 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107016692 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 56107016693 acyl-activating enzyme (AAE) consensus motif; other site 56107016694 AMP binding site [chemical binding]; other site 56107016695 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016696 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 56107016697 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107016698 active site 56107016699 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107016700 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 56107016701 putative NADP binding site [chemical binding]; other site 56107016702 KR domain; Region: KR; pfam08659 56107016703 active site 56107016704 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016705 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107016706 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 56107016707 acyl-activating enzyme (AAE) consensus motif; other site 56107016708 AMP binding site [chemical binding]; other site 56107016709 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016710 Condensation domain; Region: Condensation; pfam00668 56107016711 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107016712 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107016713 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 56107016714 acyl-activating enzyme (AAE) consensus motif; other site 56107016715 AMP binding site [chemical binding]; other site 56107016716 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016717 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 56107016718 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 56107016719 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 56107016720 Condensation domain; Region: Condensation; pfam00668 56107016721 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107016722 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107016723 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 56107016724 acyl-activating enzyme (AAE) consensus motif; other site 56107016725 AMP binding site [chemical binding]; other site 56107016726 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016727 Condensation domain; Region: Condensation; pfam00668 56107016728 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107016729 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 56107016730 acyl-activating enzyme (AAE) consensus motif; other site 56107016731 AMP binding site [chemical binding]; other site 56107016732 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016733 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 56107016734 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 56107016735 active site 56107016736 Acyl transferase domain; Region: Acyl_transf_1; cl08282 56107016737 Acyl transferase domain; Region: Acyl_transf_1; cl08282 56107016738 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 56107016739 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 56107016740 putative NADP binding site [chemical binding]; other site 56107016741 active site 56107016742 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016743 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 56107016744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 56107016745 H+ Antiporter protein; Region: 2A0121; TIGR00900 56107016746 putative substrate translocation pore; other site 56107016747 MbtH-like protein; Region: MbtH; pfam03621 56107016748 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 56107016749 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 56107016750 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 56107016751 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 56107016752 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 56107016753 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 56107016754 active site 56107016755 FkbH-like domain; Region: FkbH; TIGR01686 56107016756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 56107016757 active site 56107016758 motif I; other site 56107016759 motif II; other site 56107016760 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107016761 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107016762 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016763 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 56107016764 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 56107016765 DDE superfamily endonuclease; Region: DDE_3; pfam13358 56107016766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 56107016767 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 56107016768 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107016769 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107016770 active site 56107016771 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 56107016772 active site 56107016773 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 56107016774 putative active site pocket [active] 56107016775 dimerization interface [polypeptide binding]; other site 56107016776 putative catalytic residue [active] 56107016777 Condensation domain; Region: Condensation; pfam00668 56107016778 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 56107016779 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 56107016780 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 56107016781 acyl-activating enzyme (AAE) consensus motif; other site 56107016782 AMP binding site [chemical binding]; other site 56107016783 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 56107016784 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 56107016785 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 56107016786 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 56107016787 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 56107016788 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 56107016789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 56107016790 S-adenosylmethionine binding site [chemical binding]; other site 56107016791 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107016792 active site 56107016793 catalytic residues [active] 56107016794 DNA binding site [nucleotide binding] 56107016795 Int/Topo IB signature motif; other site 56107016796 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 56107016797 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107016798 P-loop; other site 56107016799 Magnesium ion binding site [ion binding]; other site 56107016800 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 56107016801 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107016802 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 56107016803 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 56107016804 protein I interface; other site 56107016805 D2 interface; other site 56107016806 protein T interface; other site 56107016807 chlorophyll binding site; other site 56107016808 beta carotene binding site; other site 56107016809 pheophytin binding site; other site 56107016810 manganese-stabilizing polypeptide interface; other site 56107016811 CP43 interface; other site 56107016812 protein L interface; other site 56107016813 oxygen evolving complex binding site; other site 56107016814 bromide binding site; other site 56107016815 quinone binding site; other site 56107016816 Fe binding site [ion binding]; other site 56107016817 core light harvesting interface; other site 56107016818 cytochrome b559 alpha subunit interface; other site 56107016819 cytochrome c-550 interface; other site 56107016820 protein J interface; other site 56107016821 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 56107016822 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 56107016823 Ribbon-helix-helix domain; Region: RHH_4; cl01775 56107016824 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 56107016825 active site 56107016826 metal binding site [ion binding]; metal-binding site 56107016827 interdomain interaction site; other site 56107016828 Part of AAA domain; Region: AAA_19; pfam13245 56107016829 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 56107016830 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 56107016831 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 56107016832 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 56107016833 putative active site [active] 56107016834 putative NTP binding site [chemical binding]; other site 56107016835 putative nucleic acid binding site [nucleotide binding]; other site 56107016836 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 56107016837 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107016838 active site 56107016839 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 56107016840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 56107016841 Transposase; Region: DDE_Tnp_ISL3; pfam01610 56107016842 Transposase; Region: DDE_Tnp_ISL3; pfam01610 56107016843 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 56107016844 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 56107016845 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 56107016846 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 56107016847 active site 56107016848 DNA binding site [nucleotide binding] 56107016849 Int/Topo IB signature motif; other site 56107016850 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 56107016851 Part of AAA domain; Region: AAA_19; pfam13245 56107016852 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 56107016853 putative addiction module antidote; Region: doc_partner; TIGR02609 56107016854 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 56107016855 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 56107016856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107016857 Walker A motif; other site 56107016858 ATP binding site [chemical binding]; other site 56107016859 HEAT repeats; Region: HEAT_2; pfam13646 56107016860 HEAT repeats; Region: HEAT_2; pfam13646 56107016861 HEAT repeats; Region: HEAT_2; pfam13646 56107016862 HEAT repeats; Region: HEAT_2; pfam13646 56107016863 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 56107016864 protein binding surface [polypeptide binding]; other site 56107016865 HEAT repeats; Region: HEAT_2; pfam13646 56107016866 NB-ARC domain; Region: NB-ARC; pfam00931 56107016867 ParA-like protein; Provisional; Region: PHA02518 56107016868 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107016869 P-loop; other site 56107016870 Magnesium ion binding site [ion binding]; other site 56107016871 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 56107016872 putative active site [active] 56107016873 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107016874 active site 56107016875 catalytic residues [active] 56107016876 DNA binding site [nucleotide binding] 56107016877 Int/Topo IB signature motif; other site 56107016878 Protein of unknown function (DUF433); Region: DUF433; pfam04255 56107016879 Uncharacterized conserved protein [Function unknown]; Region: COG5464 56107016880 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 56107016881 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 56107016882 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 56107016883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107016884 non-specific DNA binding site [nucleotide binding]; other site 56107016885 salt bridge; other site 56107016886 sequence-specific DNA binding site [nucleotide binding]; other site 56107016887 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 56107016888 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 56107016889 Putative transcription activator [Transcription]; Region: TenA; COG0819 56107016890 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 56107016891 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 56107016892 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 56107016893 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 56107016894 active site 56107016895 substrate binding site [chemical binding]; other site 56107016896 Mg2+ binding site [ion binding]; other site 56107016897 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 56107016898 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 56107016899 active site 56107016900 catalytic site [active] 56107016901 substrate binding site [chemical binding]; other site 56107016902 Phylum Aquificae Pol A is different from Escherichia coli Pol A by three signature sequences; Region: DNA_pol_A_Aquificae_like; cd08639 56107016903 active site 56107016904 DNA binding site [nucleotide binding] 56107016905 catalytic site [active] 56107016906 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107016907 putative active site [active] 56107016908 TniQ; Region: TniQ; pfam06527 56107016909 AAA domain; Region: AAA_22; pfam13401 56107016910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 56107016911 Walker A motif; other site 56107016912 ATP binding site [chemical binding]; other site 56107016913 Walker B motif; other site 56107016914 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 56107016915 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 56107016916 Integrase core domain; Region: rve; pfam00665 56107016917 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 56107016918 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 56107016919 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 56107016920 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 56107016921 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 56107016922 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 56107016923 DNA polymerase III subunit delta; Validated; Region: PRK07452 56107016924 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 56107016925 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 56107016926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 56107016927 Walker A motif; other site 56107016928 ATP binding site [chemical binding]; other site 56107016929 Walker B motif; other site 56107016930 arginine finger; other site 56107016931 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 56107016932 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 56107016933 DNA polymerase III subunit beta; Validated; Region: PRK05643 56107016934 putative DNA binding surface [nucleotide binding]; other site 56107016935 dimer interface [polypeptide binding]; other site 56107016936 beta-clamp/clamp loader binding surface; other site 56107016937 beta-clamp/translesion DNA polymerase binding surface; other site 56107016938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107016939 non-specific DNA binding site [nucleotide binding]; other site 56107016940 salt bridge; other site 56107016941 sequence-specific DNA binding site [nucleotide binding]; other site 56107016942 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 56107016943 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 56107016944 AAA domain; Region: AAA_30; pfam13604 56107016945 Family description; Region: UvrD_C_2; pfam13538 56107016946 PAS domain; Region: PAS; smart00091 56107016947 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 56107016948 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 56107016949 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 56107016950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 56107016951 dimer interface [polypeptide binding]; other site 56107016952 phosphorylation site [posttranslational modification] 56107016953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 56107016954 ATP binding site [chemical binding]; other site 56107016955 Mg2+ binding site [ion binding]; other site 56107016956 G-X-G motif; other site 56107016957 Response regulator receiver domain; Region: Response_reg; pfam00072 56107016958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 56107016959 active site 56107016960 phosphorylation site [posttranslational modification] 56107016961 intermolecular recognition site; other site 56107016962 dimerization interface [polypeptide binding]; other site 56107016963 ParB-like nuclease domain; Region: ParBc; pfam02195 56107016964 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 56107016965 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107016966 P-loop; other site 56107016967 Magnesium ion binding site [ion binding]; other site 56107016968 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107016969 Magnesium ion binding site [ion binding]; other site 56107016970 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 56107016971 AAA-like domain; Region: AAA_10; pfam12846 56107016972 RNA dependent RNA polymerase; Region: RdRP; pfam05183 56107016973 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 56107016974 putative active site [active] 56107016975 catalytic site [active] 56107016976 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 56107016977 ATP binding site [chemical binding]; other site 56107016978 putative Mg++ binding site [ion binding]; other site 56107016979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 56107016980 nucleotide binding region [chemical binding]; other site 56107016981 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 56107016982 putative active site [active] 56107016983 Gtr1/RagA G protein conserved region; Region: Gtr1_RagA; pfam04670 56107016984 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550 56107016985 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 56107016986 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 56107016987 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 56107016988 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 56107016989 Protein of unknown function (DUF499); Region: DUF499; pfam04465 56107016990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107016991 non-specific DNA binding site [nucleotide binding]; other site 56107016992 salt bridge; other site 56107016993 sequence-specific DNA binding site [nucleotide binding]; other site 56107016994 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 56107016995 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 56107016996 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107016997 active site 56107016998 catalytic residues [active] 56107016999 DNA binding site [nucleotide binding] 56107017000 Int/Topo IB signature motif; other site 56107017001 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 56107017002 classical (c) SDRs; Region: SDR_c; cd05233 56107017003 NAD(P) binding site [chemical binding]; other site 56107017004 active site 56107017005 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 56107017006 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 56107017007 active site 56107017008 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 56107017009 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 56107017010 PYR/PP interface [polypeptide binding]; other site 56107017011 dimer interface [polypeptide binding]; other site 56107017012 TPP binding site [chemical binding]; other site 56107017013 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 56107017014 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 56107017015 TPP-binding site [chemical binding]; other site 56107017016 AAA ATPase domain; Region: AAA_16; pfam13191 56107017017 NACHT domain; Region: NACHT; pfam05729 56107017018 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107017019 structural tetrad; other site 56107017020 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107017021 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107017022 structural tetrad; other site 56107017023 Caspase domain; Region: Peptidase_C14; pfam00656 56107017024 AAA ATPase domain; Region: AAA_16; pfam13191 56107017025 AAA domain; Region: AAA_23; pfam13476 56107017026 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107017027 structural tetrad; other site 56107017028 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107017029 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107017030 structural tetrad; other site 56107017031 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107017032 structural tetrad; other site 56107017033 Caspase domain; Region: Peptidase_C14; pfam00656 56107017034 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 56107017035 G1 box; other site 56107017036 GTP/Mg2+ binding site [chemical binding]; other site 56107017037 G2 box; other site 56107017038 Switch I region; other site 56107017039 G3 box; other site 56107017040 Switch II region; other site 56107017041 G4 box; other site 56107017042 G5 box; other site 56107017043 AAA ATPase domain; Region: AAA_16; pfam13191 56107017044 NACHT domain; Region: NACHT; pfam05729 56107017045 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107017046 structural tetrad; other site 56107017047 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107017048 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107017049 structural tetrad; other site 56107017050 WD40 repeats; Region: WD40; smart00320 56107017051 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 56107017052 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 56107017053 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 56107017054 active site 56107017055 DNA binding site [nucleotide binding] 56107017056 Int/Topo IB signature motif; other site 56107017057 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 56107017058 Transposase; Region: DDE_Tnp_ISL3; pfam01610 56107017059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 56107017060 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 56107017061 Transposase; Region: DDE_Tnp_ISL3; pfam01610 56107017062 hypothetical protein; Reviewed; Region: PRK12275 56107017063 four helix bundle protein; Region: TIGR02436 56107017064 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 56107017065 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 56107017066 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107017067 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 56107017068 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 56107017069 Protein of unknown function (DUF429); Region: DUF429; cl12046 56107017070 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 56107017071 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 56107017072 Helix-turn-helix domain; Region: HTH_28; pfam13518 56107017073 Integrase core domain; Region: rve; pfam00665 56107017074 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 56107017075 sulfotransferase; Region: PLN02164 56107017076 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 56107017077 sulfotransferase; Region: PLN02164 56107017078 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 56107017079 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 56107017080 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 56107017081 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 56107017082 cytidylate kinase; Provisional; Region: cmk; PRK00023 56107017083 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 56107017084 ligand-binding site [chemical binding]; other site 56107017085 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 56107017086 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 56107017087 catalytic residue [active] 56107017088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 56107017089 DDE superfamily endonuclease; Region: DDE_3; pfam13358 56107017090 Transposase; Region: HTH_Tnp_IS630; pfam01710 56107017091 Homeodomain-like domain; Region: HTH_32; pfam13565 56107017092 Winged helix-turn helix; Region: HTH_33; pfam13592 56107017093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 56107017094 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 56107017095 Coenzyme A binding pocket [chemical binding]; other site 56107017096 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 56107017097 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107017098 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107017099 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107017100 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107017101 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107017102 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 56107017103 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 56107017104 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 56107017105 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 56107017106 GLases (alpha-1,4-glucan lyases) are glycosyl hydrolase family 31 (GH31) enzymes that degrade alpha-1,4-glucans and maltooligosaccharides via a nonhydrolytic pathway to yield 1,5-D-anhydrofructose from the nonreducing end. GLases cleave the bond between...; Region: GH31_lyase_GLase; cd06601 56107017107 putative active site [active] 56107017108 putative catalytic site [active] 56107017109 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 56107017110 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107017111 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107017112 structural tetrad; other site 56107017113 FOG: WD40 repeat [General function prediction only]; Region: COG2319 56107017114 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 56107017115 structural tetrad; other site 56107017116 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 56107017117 ParB-like nuclease domain; Region: ParBc; pfam02195 56107017118 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 56107017119 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107017120 P-loop; other site 56107017121 Magnesium ion binding site [ion binding]; other site 56107017122 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 56107017123 Magnesium ion binding site [ion binding]; other site 56107017124 Ycf46; Provisional; Region: ycf46; CHL00195 56107017125 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 56107017126 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 56107017127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 56107017128 binding surface 56107017129 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107017130 TPR motif; other site 56107017131 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107017132 Tetratricopeptide repeat; Region: TPR_12; pfam13424 56107017133 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 56107017134 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 56107017135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 56107017136 HEAT repeats; Region: HEAT_2; pfam13646 56107017137 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 56107017138 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 56107017139 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 56107017140 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 56107017141 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 56107017142 putative active site [active] 56107017143 putative NTP binding site [chemical binding]; other site 56107017144 putative nucleic acid binding site [nucleotide binding]; other site 56107017145 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 56107017146 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107017147 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107017148 active site 56107017149 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 56107017150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107017151 salt bridge; other site 56107017152 non-specific DNA binding site [nucleotide binding]; other site 56107017153 sequence-specific DNA binding site [nucleotide binding]; other site 56107017154 Double zinc ribbon; Region: DZR; pfam12773 56107017155 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 56107017156 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 56107017157 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 56107017158 active site 56107017159 catalytic residues [active] 56107017160 DNA binding site [nucleotide binding] 56107017161 Int/Topo IB signature motif; other site 56107017162 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 56107017163 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 56107017164 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 56107017165 putative active site [active] 56107017166 putative NTP binding site [chemical binding]; other site 56107017167 putative nucleic acid binding site [nucleotide binding]; other site 56107017168 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 56107017169 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 56107017170 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 56107017171 active site 56107017172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107017173 non-specific DNA binding site [nucleotide binding]; other site 56107017174 salt bridge; other site 56107017175 sequence-specific DNA binding site [nucleotide binding]; other site 56107017176 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 56107017177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 56107017178 non-specific DNA binding site [nucleotide binding]; other site 56107017179 salt bridge; other site 56107017180 sequence-specific DNA binding site [nucleotide binding]; other site 56107017181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 56107017182 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 56107017183 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 56107017184 oligomeric interface; other site 56107017185 putative active site [active] 56107017186 homodimer interface [polypeptide binding]; other site 56107017187 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 56107017188 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 56107017189 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 56107017190 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 56107017191 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 56107017192 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 56107017193 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 56107017194 putative hydrophobic ligand binding site [chemical binding]; other site 56107017195 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 56107017196 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 56107017197 NAD binding site [chemical binding]; other site 56107017198 catalytic Zn binding site [ion binding]; other site 56107017199 structural Zn binding site [ion binding]; other site 56107017200 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 56107017201 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 56107017202 nucleotide binding site [chemical binding]; other site 56107017203 NEF interaction site [polypeptide binding]; other site 56107017204 SBD interface [polypeptide binding]; other site 56107017205 ChaB; Region: ChaB; cl01887 56107017206 YfdX protein; Region: YfdX; pfam10938 56107017207 YfdX protein; Region: YfdX; pfam10938 56107017208 YfdX protein; Region: YfdX; pfam10938 56107017209 chaperone protein DnaJ; Provisional; Region: PRK14299 56107017210 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 56107017211 HSP70 interaction site [polypeptide binding]; other site 56107017212 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 56107017213 substrate binding site [polypeptide binding]; other site 56107017214 dimer interface [polypeptide binding]; other site 56107017215 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 56107017216 MerR HTH family regulatory protein; Region: MerR_2; pfam13591