-- dump date   	20140619_055549
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
640081000001	aminodeoxychorismate synthase; Provisional; Region: PRK07508
640081000002	chorismate binding enzyme; Region: Chorismate_bind; cl10555
640081000003	hypothetical protein; Provisional; Region: PRK07546
640081000004	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
640081000005	substrate-cofactor binding pocket; other site
640081000006	homodimer interface [polypeptide binding]; other site
640081000007	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081000008	catalytic residue [active]
640081000009	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
640081000010	CPxP  motif; other site
640081000011	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
640081000012	Peptidase family M48; Region: Peptidase_M48; pfam01435
640081000013	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
640081000014	TPR motif; other site
640081000015	binding surface
640081000016	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
640081000017	trimer interface [polypeptide binding]; other site
640081000018	dimer interface [polypeptide binding]; other site
640081000019	putative active site [active]
640081000020	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
640081000021	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
640081000022	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
640081000023	DNA-binding site [nucleotide binding]; DNA binding site
640081000024	RNA-binding motif; other site
640081000025	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
640081000026	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
640081000027	Clp amino terminal domain; Region: Clp_N; pfam02861
640081000028	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081000029	Walker A motif; other site
640081000030	ATP binding site [chemical binding]; other site
640081000031	Walker B motif; other site
640081000032	arginine finger; other site
640081000033	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081000034	Walker A motif; other site
640081000035	ATP binding site [chemical binding]; other site
640081000036	Walker B motif; other site
640081000037	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
640081000038	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
640081000039	isocitrate lyase; Provisional; Region: PRK15063
640081000040	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
640081000041	tetramer interface [polypeptide binding]; other site
640081000042	active site
640081000043	Mg2+/Mn2+ binding site [ion binding]; other site
640081000044	EamA-like transporter family; Region: EamA; pfam00892
640081000045	Predicted membrane protein [Function unknown]; Region: COG2860
640081000046	UPF0126 domain; Region: UPF0126; pfam03458
640081000047	UPF0126 domain; Region: UPF0126; pfam03458
640081000048	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
640081000049	FOG: CBS domain [General function prediction only]; Region: COG0517
640081000050	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081000051	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081000052	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
640081000053	putative effector binding pocket; other site
640081000054	dimerization interface [polypeptide binding]; other site
640081000055	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
640081000056	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
640081000057	motif II; other site
640081000058	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
640081000059	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
640081000060	malate synthase A; Region: malate_syn_A; TIGR01344
640081000061	active site
640081000062	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
640081000063	Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460
640081000064	active site
640081000065	motif I; other site
640081000066	motif II; other site
640081000067	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
640081000068	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
640081000069	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
640081000070	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
640081000071	inhibitor-cofactor binding pocket; inhibition site
640081000072	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081000073	catalytic residue [active]
640081000074	Cytochrome C' Region: Cytochrom_C_2; pfam01322
640081000075	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
640081000076	Domain of unknown function DUF21; Region: DUF21; pfam01595
640081000077	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
640081000078	Transporter associated domain; Region: CorC_HlyC; smart01091
640081000079	LrgA family; Region: LrgA; pfam03788
640081000080	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
640081000081	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
640081000082	homodimer interface [polypeptide binding]; other site
640081000083	chemical substrate binding site [chemical binding]; other site
640081000084	oligomer interface [polypeptide binding]; other site
640081000085	metal binding site [ion binding]; metal-binding site
640081000086	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
640081000087	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
640081000088	Peptidase family M48; Region: Peptidase_M48; pfam01435
640081000089	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
640081000090	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
640081000091	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
640081000092	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
640081000093	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
640081000094	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
640081000095	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
640081000096	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
640081000097	CoA-transferase family III; Region: CoA_transf_3; pfam02515
640081000098	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
640081000099	nucleotide binding site/active site [active]
640081000100	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
640081000101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081000102	S-adenosylmethionine binding site [chemical binding]; other site
640081000103	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
640081000104	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
640081000105	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
640081000106	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081000107	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
640081000108	ligand binding site [chemical binding]; other site
640081000109	flexible hinge region; other site
640081000110	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
640081000111	non-specific DNA interactions [nucleotide binding]; other site
640081000112	DNA binding site [nucleotide binding]
640081000113	sequence specific DNA binding site [nucleotide binding]; other site
640081000114	putative cAMP binding site [chemical binding]; other site
640081000115	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
640081000116	putative catalytic site [active]
640081000117	putative phosphate binding site [ion binding]; other site
640081000118	active site
640081000119	metal binding site A [ion binding]; metal-binding site
640081000120	DNA binding site [nucleotide binding]
640081000121	putative AP binding site [nucleotide binding]; other site
640081000122	putative metal binding site B [ion binding]; other site
640081000123	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
640081000124	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
640081000125	catalytic residues [active]
640081000126	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
640081000127	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
640081000128	active site
640081000129	Zn binding site [ion binding]; other site
640081000130	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
640081000131	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
640081000132	ATP binding site [chemical binding]; other site
640081000133	active site
640081000134	substrate binding site [chemical binding]; other site
640081000135	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
640081000136	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
640081000137	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
640081000138	intersubunit interface [polypeptide binding]; other site
640081000139	active site
640081000140	zinc binding site [ion binding]; other site
640081000141	Na+ binding site [ion binding]; other site
640081000142	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
640081000143	putative FMN binding site [chemical binding]; other site
640081000144	pyruvate kinase; Provisional; Region: PRK05826
640081000145	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
640081000146	domain interfaces; other site
640081000147	active site
640081000148	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
640081000149	Bacterial sugar transferase; Region: Bac_transf; pfam02397
640081000150	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
640081000151	putative ADP-binding pocket [chemical binding]; other site
640081000152	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
640081000153	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
640081000154	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
640081000155	active site
640081000156	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
640081000157	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
640081000158	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
640081000159	Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531
640081000160	GDP-Fucose binding site [chemical binding]; other site
640081000161	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
640081000162	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
640081000163	metal-binding site
640081000164	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
640081000165	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
640081000166	NADP-binding site; other site
640081000167	homotetramer interface [polypeptide binding]; other site
640081000168	substrate binding site [chemical binding]; other site
640081000169	homodimer interface [polypeptide binding]; other site
640081000170	active site
640081000171	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
640081000172	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
640081000173	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
640081000174	Methyltransferase domain; Region: Methyltransf_12; pfam08242
640081000175	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
640081000176	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
640081000177	active site
640081000178	Cephalosporin hydroxylase; Region: CmcI; pfam04989
640081000179	Methyltransferase domain; Region: Methyltransf_23; pfam13489
640081000180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081000181	S-adenosylmethionine binding site [chemical binding]; other site
640081000182	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
640081000183	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
640081000184	extended (e) SDRs; Region: SDR_e; cd08946
640081000185	NAD(P) binding site [chemical binding]; other site
640081000186	active site
640081000187	substrate binding site [chemical binding]; other site
640081000188	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
640081000189	Methyltransferase domain; Region: Methyltransf_23; pfam13489
640081000190	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
640081000191	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
640081000192	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
640081000193	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
640081000194	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
640081000195	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
640081000196	NAD binding site [chemical binding]; other site
640081000197	homotetramer interface [polypeptide binding]; other site
640081000198	homodimer interface [polypeptide binding]; other site
640081000199	substrate binding site [chemical binding]; other site
640081000200	active site
640081000201	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
640081000202	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
640081000203	substrate binding site; other site
640081000204	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
640081000205	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
640081000206	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
640081000207	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
640081000208	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
640081000209	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
640081000210	inhibitor-cofactor binding pocket; inhibition site
640081000211	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081000212	catalytic residue [active]
640081000213	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
640081000214	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
640081000215	pseudaminic acid synthase; Region: PseI; TIGR03586
640081000216	NeuB family; Region: NeuB; pfam03102
640081000217	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
640081000218	NeuB binding interface [polypeptide binding]; other site
640081000219	putative substrate binding site [chemical binding]; other site
640081000220	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
640081000221	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
640081000222	ligand binding site; other site
640081000223	tetramer interface; other site
640081000224	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
640081000225	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
640081000226	inhibitor-cofactor binding pocket; inhibition site
640081000227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081000228	catalytic residue [active]
640081000229	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
640081000230	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
640081000231	NAD(P) binding site [chemical binding]; other site
640081000232	homodimer interface [polypeptide binding]; other site
640081000233	substrate binding site [chemical binding]; other site
640081000234	active site
640081000235	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
640081000236	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
640081000237	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081000238	Walker A/P-loop; other site
640081000239	ATP binding site [chemical binding]; other site
640081000240	Q-loop/lid; other site
640081000241	ABC transporter signature motif; other site
640081000242	Walker B; other site
640081000243	D-loop; other site
640081000244	H-loop/switch region; other site
640081000245	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
640081000246	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
640081000247	NADP-binding site; other site
640081000248	homotetramer interface [polypeptide binding]; other site
640081000249	substrate binding site [chemical binding]; other site
640081000250	homodimer interface [polypeptide binding]; other site
640081000251	active site
640081000252	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
640081000253	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
640081000254	NADP binding site [chemical binding]; other site
640081000255	active site
640081000256	putative substrate binding site [chemical binding]; other site
640081000257	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
640081000258	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
640081000259	Substrate binding site; other site
640081000260	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
640081000261	Cache domain; Region: Cache_2; pfam08269
640081000262	HAMP domain; Region: HAMP; pfam00672
640081000263	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081000264	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081000265	dimer interface [polypeptide binding]; other site
640081000266	putative CheW interface [polypeptide binding]; other site
640081000267	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
640081000268	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
640081000269	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
640081000270	ATP-grasp domain; Region: ATP-grasp; pfam02222
640081000271	AIR carboxylase; Region: AIRC; pfam00731
640081000272	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
640081000273	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
640081000274	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
640081000275	homodimer interface [polypeptide binding]; other site
640081000276	NADP binding site [chemical binding]; other site
640081000277	substrate binding site [chemical binding]; other site
640081000278	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
640081000279	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
640081000280	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
640081000281	dimer interface [polypeptide binding]; other site
640081000282	PYR/PP interface [polypeptide binding]; other site
640081000283	TPP binding site [chemical binding]; other site
640081000284	substrate binding site [chemical binding]; other site
640081000285	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
640081000286	TPP-binding site; other site
640081000287	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
640081000288	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081000289	dimerization interface [polypeptide binding]; other site
640081000290	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081000291	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081000292	dimer interface [polypeptide binding]; other site
640081000293	putative CheW interface [polypeptide binding]; other site
640081000294	Predicted metal-binding protein [General function prediction only]; Region: COG3019
640081000295	Proteolipid membrane potential modulator; Region: Pmp3; cl00431
640081000296	outer membrane lipoprotein; Provisional; Region: PRK11023
640081000297	BON domain; Region: BON; pfam04972
640081000298	BON domain; Region: BON; pfam04972
640081000299	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
640081000300	dimer interface [polypeptide binding]; other site
640081000301	active site
640081000302	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
640081000303	active site
640081000304	catalytic site [active]
640081000305	substrate binding site [chemical binding]; other site
640081000306	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
640081000307	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
640081000308	GIY-YIG motif/motif A; other site
640081000309	active site
640081000310	catalytic site [active]
640081000311	putative DNA binding site [nucleotide binding]; other site
640081000312	metal binding site [ion binding]; metal-binding site
640081000313	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
640081000314	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
640081000315	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
640081000316	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
640081000317	HPP family; Region: HPP; pfam04982
640081000318	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
640081000319	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
640081000320	NAD binding site [chemical binding]; other site
640081000321	catalytic residues [active]
640081000322	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
640081000323	dinuclear metal binding motif [ion binding]; other site
640081000324	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
640081000325	Peptidase family M48; Region: Peptidase_M48; cl12018
640081000326	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
640081000327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081000328	active site
640081000329	phosphorylation site [posttranslational modification]
640081000330	intermolecular recognition site; other site
640081000331	dimerization interface [polypeptide binding]; other site
640081000332	LytTr DNA-binding domain; Region: LytTR; smart00850
640081000333	Histidine kinase; Region: His_kinase; pfam06580
640081000334	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
640081000335	argininosuccinate lyase; Provisional; Region: PRK00855
640081000336	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
640081000337	active sites [active]
640081000338	tetramer interface [polypeptide binding]; other site
640081000339	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
640081000340	Catalytic domain of Protein Kinases; Region: PKc; cd00180
640081000341	active site
640081000342	ATP binding site [chemical binding]; other site
640081000343	substrate binding site [chemical binding]; other site
640081000344	activation loop (A-loop); other site
640081000345	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081000346	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081000347	ligand binding site [chemical binding]; other site
640081000348	flexible hinge region; other site
640081000349	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
640081000350	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
640081000351	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
640081000352	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081000353	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081000354	dimer interface [polypeptide binding]; other site
640081000355	putative CheW interface [polypeptide binding]; other site
640081000356	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
640081000357	putative GSH binding site [chemical binding]; other site
640081000358	catalytic residues [active]
640081000359	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
640081000360	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081000361	S-adenosylmethionine binding site [chemical binding]; other site
640081000362	peptide chain release factor 1; Validated; Region: prfA; PRK00591
640081000363	This domain is found in peptide chain release factors; Region: PCRF; smart00937
640081000364	RF-1 domain; Region: RF-1; pfam00472
640081000365	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
640081000366	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
640081000367	tRNA; other site
640081000368	putative tRNA binding site [nucleotide binding]; other site
640081000369	putative NADP binding site [chemical binding]; other site
640081000370	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
640081000371	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
640081000372	putative active site [active]
640081000373	dimerization interface [polypeptide binding]; other site
640081000374	putative tRNAtyr binding site [nucleotide binding]; other site
640081000375	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
640081000376	glycerate dehydrogenase; Provisional; Region: PRK06932
640081000377	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
640081000378	putative ligand binding site [chemical binding]; other site
640081000379	putative NAD binding site [chemical binding]; other site
640081000380	catalytic site [active]
640081000381	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
640081000382	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
640081000383	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
640081000384	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
640081000385	4Fe-4S binding domain; Region: Fer4; pfam00037
640081000386	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
640081000387	Transcriptional regulator [Transcription]; Region: IclR; COG1414
640081000388	Bacterial transcriptional regulator; Region: IclR; pfam01614
640081000389	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
640081000390	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
640081000391	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
640081000392	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
640081000393	active site
640081000394	nucleophile elbow; other site
640081000395	malic enzyme; Reviewed; Region: PRK12862
640081000396	Malic enzyme, N-terminal domain; Region: malic; pfam00390
640081000397	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
640081000398	putative NAD(P) binding site [chemical binding]; other site
640081000399	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
640081000400	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
640081000401	active site
640081000402	substrate-binding site [chemical binding]; other site
640081000403	metal-binding site [ion binding]
640081000404	GTP binding site [chemical binding]; other site
640081000405	hypothetical protein; Provisional; Region: PRK08960
640081000406	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081000407	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081000408	homodimer interface [polypeptide binding]; other site
640081000409	catalytic residue [active]
640081000410	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
640081000411	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
640081000412	amidase catalytic site [active]
640081000413	Zn binding residues [ion binding]; other site
640081000414	substrate binding site [chemical binding]; other site
640081000415	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
640081000416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081000417	active site
640081000418	phosphorylation site [posttranslational modification]
640081000419	intermolecular recognition site; other site
640081000420	dimerization interface [polypeptide binding]; other site
640081000421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081000422	Walker A motif; other site
640081000423	ATP binding site [chemical binding]; other site
640081000424	Walker B motif; other site
640081000425	arginine finger; other site
640081000426	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081000427	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081000428	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081000429	dimer interface [polypeptide binding]; other site
640081000430	phosphorylation site [posttranslational modification]
640081000431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081000432	ATP binding site [chemical binding]; other site
640081000433	Mg2+ binding site [ion binding]; other site
640081000434	G-X-G motif; other site
640081000435	integrase; Provisional; Region: int; PHA02601
640081000436	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
640081000437	active site
640081000438	DNA binding site [nucleotide binding]
640081000439	Int/Topo IB signature motif; other site
640081000440	Translocation protein Sec62; Region: Sec62; cl02170
640081000441	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
640081000442	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081000443	FeS/SAM binding site; other site
640081000444	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
640081000445	Ethylbenzene dehydrogenase; Region: EB_dh; smart00887
640081000446	putative ligand binding site [chemical binding]; other site
640081000447	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
640081000448	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
640081000449	Chlorite dismutase; Region: Chlor_dismutase; pfam06778
640081000450	DMSO reductase family type II enzyme chaperone; Region: DMSO_red_II_cha; TIGR03482
640081000451	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
640081000452	DMSO reductase family type II enzyme, iron-sulfur subunit; Region: DMSO_red_II_bet; TIGR03478
640081000453	DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479
640081000454	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
640081000455	[4Fe-4S] binding site [ion binding]; other site
640081000456	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
640081000457	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
640081000458	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
640081000459	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
640081000460	molybdopterin cofactor binding site; other site
640081000461	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
640081000462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081000463	active site
640081000464	phosphorylation site [posttranslational modification]
640081000465	intermolecular recognition site; other site
640081000466	dimerization interface [polypeptide binding]; other site
640081000467	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081000468	Walker A motif; other site
640081000469	ATP binding site [chemical binding]; other site
640081000470	Walker B motif; other site
640081000471	arginine finger; other site
640081000472	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081000473	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081000474	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081000475	dimerization interface [polypeptide binding]; other site
640081000476	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081000477	dimer interface [polypeptide binding]; other site
640081000478	phosphorylation site [posttranslational modification]
640081000479	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081000480	ATP binding site [chemical binding]; other site
640081000481	Mg2+ binding site [ion binding]; other site
640081000482	G-X-G motif; other site
640081000483	PAS fold; Region: PAS_4; pfam08448
640081000484	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081000485	putative active site [active]
640081000486	heme pocket [chemical binding]; other site
640081000487	PAS domain S-box; Region: sensory_box; TIGR00229
640081000488	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081000489	putative active site [active]
640081000490	heme pocket [chemical binding]; other site
640081000491	Cupin domain; Region: Cupin_2; cl17218
640081000492	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
640081000493	RNA polymerase sigma factor; Provisional; Region: PRK12536
640081000494	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081000495	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081000496	DNA binding residues [nucleotide binding]
640081000497	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
640081000498	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
640081000499	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
640081000500	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
640081000501	Moco binding site; other site
640081000502	metal coordination site [ion binding]; other site
640081000503	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
640081000504	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
640081000505	substrate binding pocket [chemical binding]; other site
640081000506	chain length determination region; other site
640081000507	substrate-Mg2+ binding site; other site
640081000508	catalytic residues [active]
640081000509	aspartate-rich region 1; other site
640081000510	active site lid residues [active]
640081000511	aspartate-rich region 2; other site
640081000512	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
640081000513	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
640081000514	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
640081000515	GTPase CgtA; Reviewed; Region: obgE; PRK12299
640081000516	GTP1/OBG; Region: GTP1_OBG; pfam01018
640081000517	Obg GTPase; Region: Obg; cd01898
640081000518	G1 box; other site
640081000519	GTP/Mg2+ binding site [chemical binding]; other site
640081000520	Switch I region; other site
640081000521	G2 box; other site
640081000522	G3 box; other site
640081000523	Switch II region; other site
640081000524	G4 box; other site
640081000525	G5 box; other site
640081000526	gamma-glutamyl kinase; Provisional; Region: PRK05429
640081000527	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
640081000528	nucleotide binding site [chemical binding]; other site
640081000529	homotetrameric interface [polypeptide binding]; other site
640081000530	putative phosphate binding site [ion binding]; other site
640081000531	putative allosteric binding site; other site
640081000532	PUA domain; Region: PUA; pfam01472
640081000533	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
640081000534	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
640081000535	trimer interface [polypeptide binding]; other site
640081000536	eyelet of channel; other site
640081000537	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
640081000538	active site
640081000539	ribulose/triose binding site [chemical binding]; other site
640081000540	phosphate binding site [ion binding]; other site
640081000541	substrate (anthranilate) binding pocket [chemical binding]; other site
640081000542	product (indole) binding pocket [chemical binding]; other site
640081000543	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
640081000544	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
640081000545	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
640081000546	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
640081000547	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
640081000548	glutamine binding [chemical binding]; other site
640081000549	catalytic triad [active]
640081000550	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
640081000551	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
640081000552	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
640081000553	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
640081000554	cofactor binding site; other site
640081000555	DNA binding site [nucleotide binding]
640081000556	substrate interaction site [chemical binding]; other site
640081000557	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
640081000558	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081000559	Walker A/P-loop; other site
640081000560	ATP binding site [chemical binding]; other site
640081000561	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
640081000562	Ribosome modulation factor; Region: RMF; cl01207
640081000563	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
640081000564	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
640081000565	active site
640081000566	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
640081000567	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
640081000568	sequence-specific DNA binding site [nucleotide binding]; other site
640081000569	salt bridge; other site
640081000570	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
640081000571	Catalytic site [active]
640081000572	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
640081000573	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
640081000574	non-specific DNA binding site [nucleotide binding]; other site
640081000575	salt bridge; other site
640081000576	sequence-specific DNA binding site [nucleotide binding]; other site
640081000577	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
640081000578	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
640081000579	ATP binding site [chemical binding]; other site
640081000580	putative Mg++ binding site [ion binding]; other site
640081000581	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
640081000582	DNA methylase; Region: N6_N4_Mtase; cl17433
640081000583	Protein of unknown function (DUF1376); Region: DUF1376; pfam07120
640081000584	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
640081000585	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
640081000586	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
640081000587	Phage portal protein; Region: Phage_portal; pfam04860
640081000588	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
640081000589	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
640081000590	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
640081000591	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
640081000592	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
640081000593	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
640081000594	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
640081000595	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
640081000596	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
640081000597	NlpC/P60 family; Region: NLPC_P60; cl17555
640081000598	Putative phage tail protein; Region: Phage-tail_3; pfam13550
640081000599	TIGR02594 family protein; Region: TIGR02594
640081000600	integrase; Provisional; Region: PRK09692
640081000601	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
640081000602	active site
640081000603	Int/Topo IB signature motif; other site
640081000604	anthranilate synthase component I; Provisional; Region: PRK13565
640081000605	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
640081000606	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
640081000607	phosphoglycolate phosphatase; Provisional; Region: PRK13222
640081000608	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
640081000609	motif II; other site
640081000610	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
640081000611	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
640081000612	substrate binding site [chemical binding]; other site
640081000613	hexamer interface [polypeptide binding]; other site
640081000614	metal binding site [ion binding]; metal-binding site
640081000615	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
640081000616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081000617	S-adenosylmethionine binding site [chemical binding]; other site
640081000618	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
640081000619	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081000620	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
640081000621	dimerization interface [polypeptide binding]; other site
640081000622	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
640081000623	heterotetramer interface [polypeptide binding]; other site
640081000624	active site pocket [active]
640081000625	cleavage site
640081000626	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
640081000627	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
640081000628	SEC-C motif; Region: SEC-C; pfam02810
640081000629	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
640081000630	Peptidase family M23; Region: Peptidase_M23; pfam01551
640081000631	Protein of unknown function (DUF721); Region: DUF721; cl02324
640081000632	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
640081000633	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
640081000634	cell division protein FtsZ; Validated; Region: PRK09330
640081000635	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
640081000636	nucleotide binding site [chemical binding]; other site
640081000637	SulA interaction site; other site
640081000638	cell division protein FtsA; Region: ftsA; TIGR01174
640081000639	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
640081000640	nucleotide binding site [chemical binding]; other site
640081000641	Cell division protein FtsA; Region: FtsA; pfam14450
640081000642	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
640081000643	Cell division protein FtsQ; Region: FtsQ; pfam03799
640081000644	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
640081000645	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
640081000646	ATP-grasp domain; Region: ATP-grasp_4; cl17255
640081000647	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
640081000648	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
640081000649	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
640081000650	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
640081000651	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
640081000652	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
640081000653	active site
640081000654	homodimer interface [polypeptide binding]; other site
640081000655	cell division protein FtsW; Region: ftsW; TIGR02614
640081000656	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
640081000657	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
640081000658	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
640081000659	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
640081000660	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
640081000661	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
640081000662	Mg++ binding site [ion binding]; other site
640081000663	putative catalytic motif [active]
640081000664	putative substrate binding site [chemical binding]; other site
640081000665	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
640081000666	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
640081000667	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
640081000668	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
640081000669	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
640081000670	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
640081000671	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
640081000672	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
640081000673	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
640081000674	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
640081000675	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
640081000676	Cell division protein FtsL; Region: FtsL; pfam04999
640081000677	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
640081000678	MraW methylase family; Region: Methyltransf_5; cl17771
640081000679	cell division protein MraZ; Reviewed; Region: PRK00326
640081000680	MraZ protein; Region: MraZ; pfam02381
640081000681	MraZ protein; Region: MraZ; pfam02381
640081000682	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
640081000683	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
640081000684	active site
640081000685	substrate binding pocket [chemical binding]; other site
640081000686	dimer interface [polypeptide binding]; other site
640081000687	Predicted methyltransferases [General function prediction only]; Region: COG0313
640081000688	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
640081000689	putative SAM binding site [chemical binding]; other site
640081000690	putative homodimer interface [polypeptide binding]; other site
640081000691	hypothetical protein; Reviewed; Region: PRK12497
640081000692	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
640081000693	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
640081000694	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
640081000695	active site
640081000696	HIGH motif; other site
640081000697	dimer interface [polypeptide binding]; other site
640081000698	KMSKS motif; other site
640081000699	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
640081000700	RNA binding surface [nucleotide binding]; other site
640081000701	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
640081000702	dinuclear metal binding motif [ion binding]; other site
640081000703	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
640081000704	catalytic residues [active]
640081000705	dimer interface [polypeptide binding]; other site
640081000706	putative GTP cyclohydrolase; Provisional; Region: PRK13674
640081000707	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
640081000708	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
640081000709	Walker A/P-loop; other site
640081000710	ATP binding site [chemical binding]; other site
640081000711	Q-loop/lid; other site
640081000712	ABC transporter signature motif; other site
640081000713	Walker B; other site
640081000714	D-loop; other site
640081000715	H-loop/switch region; other site
640081000716	TOBE-like domain; Region: TOBE_3; pfam12857
640081000717	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
640081000718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081000719	dimer interface [polypeptide binding]; other site
640081000720	conserved gate region; other site
640081000721	putative PBP binding loops; other site
640081000722	ABC-ATPase subunit interface; other site
640081000723	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
640081000724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081000725	dimer interface [polypeptide binding]; other site
640081000726	conserved gate region; other site
640081000727	putative PBP binding loops; other site
640081000728	ABC-ATPase subunit interface; other site
640081000729	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
640081000730	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
640081000731	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081000732	PAS domain; Region: PAS_9; pfam13426
640081000733	putative active site [active]
640081000734	heme pocket [chemical binding]; other site
640081000735	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081000736	PAS domain; Region: PAS_9; pfam13426
640081000737	putative active site [active]
640081000738	heme pocket [chemical binding]; other site
640081000739	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081000740	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081000741	metal binding site [ion binding]; metal-binding site
640081000742	active site
640081000743	I-site; other site
640081000744	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081000745	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
640081000746	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
640081000747	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081000748	HAMP domain; Region: HAMP; pfam00672
640081000749	dimerization interface [polypeptide binding]; other site
640081000750	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081000751	dimer interface [polypeptide binding]; other site
640081000752	phosphorylation site [posttranslational modification]
640081000753	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081000754	ATP binding site [chemical binding]; other site
640081000755	Mg2+ binding site [ion binding]; other site
640081000756	G-X-G motif; other site
640081000757	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
640081000758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081000759	active site
640081000760	phosphorylation site [posttranslational modification]
640081000761	intermolecular recognition site; other site
640081000762	dimerization interface [polypeptide binding]; other site
640081000763	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081000764	DNA binding site [nucleotide binding]
640081000765	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
640081000766	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081000767	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
640081000768	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
640081000769	Walker A/P-loop; other site
640081000770	ATP binding site [chemical binding]; other site
640081000771	Q-loop/lid; other site
640081000772	ABC transporter signature motif; other site
640081000773	Walker B; other site
640081000774	D-loop; other site
640081000775	H-loop/switch region; other site
640081000776	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
640081000777	Walker A/P-loop; other site
640081000778	ATP binding site [chemical binding]; other site
640081000779	Q-loop/lid; other site
640081000780	ABC transporter signature motif; other site
640081000781	Walker B; other site
640081000782	D-loop; other site
640081000783	H-loop/switch region; other site
640081000784	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
640081000785	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
640081000786	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
640081000787	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
640081000788	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
640081000789	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
640081000790	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
640081000791	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
640081000792	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
640081000793	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081000794	active site
640081000795	phosphorylation site [posttranslational modification]
640081000796	intermolecular recognition site; other site
640081000797	dimerization interface [polypeptide binding]; other site
640081000798	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081000799	DNA binding site [nucleotide binding]
640081000800	sensor protein KdpD; Provisional; Region: PRK10490
640081000801	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
640081000802	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
640081000803	Ligand Binding Site [chemical binding]; other site
640081000804	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
640081000805	GAF domain; Region: GAF_3; pfam13492
640081000806	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081000807	dimer interface [polypeptide binding]; other site
640081000808	phosphorylation site [posttranslational modification]
640081000809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081000810	ATP binding site [chemical binding]; other site
640081000811	Mg2+ binding site [ion binding]; other site
640081000812	G-X-G motif; other site
640081000813	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
640081000814	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
640081000815	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
640081000816	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
640081000817	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
640081000818	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
640081000819	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
640081000820	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
640081000821	ring oligomerisation interface [polypeptide binding]; other site
640081000822	ATP/Mg binding site [chemical binding]; other site
640081000823	stacking interactions; other site
640081000824	hinge regions; other site
640081000825	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
640081000826	oligomerisation interface [polypeptide binding]; other site
640081000827	mobile loop; other site
640081000828	roof hairpin; other site
640081000829	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
640081000830	active site
640081000831	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
640081000832	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
640081000833	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
640081000834	ligand binding site [chemical binding]; other site
640081000835	Protein of unknown function, DUF485; Region: DUF485; pfam04341
640081000836	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
640081000837	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
640081000838	Na binding site [ion binding]; other site
640081000839	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
640081000840	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
640081000841	gating phenylalanine in ion channel; other site
640081000842	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
640081000843	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
640081000844	PilZ domain; Region: PilZ; pfam07238
640081000845	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
640081000846	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
640081000847	active site
640081000848	nucleophile elbow; other site
640081000849	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
640081000850	Ion transport protein; Region: Ion_trans; pfam00520
640081000851	Ion channel; Region: Ion_trans_2; pfam07885
640081000852	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
640081000853	Double zinc ribbon; Region: DZR; pfam12773
640081000854	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
640081000855	Coenzyme A binding pocket [chemical binding]; other site
640081000856	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
640081000857	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081000858	active site
640081000859	phosphorylation site [posttranslational modification]
640081000860	intermolecular recognition site; other site
640081000861	dimerization interface [polypeptide binding]; other site
640081000862	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081000863	binding surface
640081000864	TPR motif; other site
640081000865	Tetratricopeptide repeat; Region: TPR_16; pfam13432
640081000866	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081000867	TPR motif; other site
640081000868	binding surface
640081000869	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081000870	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081000871	ATP binding site [chemical binding]; other site
640081000872	Mg2+ binding site [ion binding]; other site
640081000873	G-X-G motif; other site
640081000874	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
640081000875	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
640081000876	UbiA prenyltransferase family; Region: UbiA; pfam01040
640081000877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081000878	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
640081000879	dimerization interface [polypeptide binding]; other site
640081000880	substrate binding pocket [chemical binding]; other site
640081000881	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081000882	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081000883	dimer interface [polypeptide binding]; other site
640081000884	putative CheW interface [polypeptide binding]; other site
640081000885	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
640081000886	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
640081000887	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
640081000888	DEAD-like helicases superfamily; Region: DEXDc; smart00487
640081000889	ATP binding site [chemical binding]; other site
640081000890	Mg++ binding site [ion binding]; other site
640081000891	motif III; other site
640081000892	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
640081000893	nucleotide binding region [chemical binding]; other site
640081000894	ATP-binding site [chemical binding]; other site
640081000895	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
640081000896	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
640081000897	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
640081000898	generic binding surface II; other site
640081000899	ssDNA binding site; other site
640081000900	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
640081000901	ATP binding site [chemical binding]; other site
640081000902	putative Mg++ binding site [ion binding]; other site
640081000903	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
640081000904	nucleotide binding region [chemical binding]; other site
640081000905	ATP-binding site [chemical binding]; other site
640081000906	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
640081000907	homotrimer interaction site [polypeptide binding]; other site
640081000908	putative active site [active]
640081000909	TPR repeat; Region: TPR_11; pfam13414
640081000910	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081000911	binding surface
640081000912	TPR motif; other site
640081000913	Sporulation related domain; Region: SPOR; pfam05036
640081000914	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
640081000915	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
640081000916	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
640081000917	dimer interface [polypeptide binding]; other site
640081000918	active site
640081000919	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
640081000920	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
640081000921	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
640081000922	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
640081000923	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
640081000924	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
640081000925	substrate binding site [chemical binding]; other site
640081000926	oxyanion hole (OAH) forming residues; other site
640081000927	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
640081000928	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
640081000929	dimer interface [polypeptide binding]; other site
640081000930	acyl-activating enzyme (AAE) consensus motif; other site
640081000931	putative active site [active]
640081000932	AMP binding site [chemical binding]; other site
640081000933	putative CoA binding site [chemical binding]; other site
640081000934	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
640081000935	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
640081000936	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
640081000937	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
640081000938	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
640081000939	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
640081000940	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
640081000941	substrate binding site [chemical binding]; other site
640081000942	oxyanion hole (OAH) forming residues; other site
640081000943	trimer interface [polypeptide binding]; other site
640081000944	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
640081000945	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
640081000946	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
640081000947	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
640081000948	acetyl-CoA acetyltransferase; Provisional; Region: PRK08170
640081000949	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
640081000950	dimer interface [polypeptide binding]; other site
640081000951	active site
640081000952	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
640081000953	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
640081000954	active site
640081000955	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
640081000956	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
640081000957	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
640081000958	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
640081000959	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
640081000960	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081000961	Walker A/P-loop; other site
640081000962	ATP binding site [chemical binding]; other site
640081000963	Q-loop/lid; other site
640081000964	ABC transporter signature motif; other site
640081000965	Walker B; other site
640081000966	D-loop; other site
640081000967	H-loop/switch region; other site
640081000968	CHASE domain; Region: CHASE; pfam03924
640081000969	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
640081000970	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081000971	putative active site [active]
640081000972	heme pocket [chemical binding]; other site
640081000973	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081000974	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081000975	dimer interface [polypeptide binding]; other site
640081000976	phosphorylation site [posttranslational modification]
640081000977	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081000978	ATP binding site [chemical binding]; other site
640081000979	Mg2+ binding site [ion binding]; other site
640081000980	G-X-G motif; other site
640081000981	Response regulator receiver domain; Region: Response_reg; pfam00072
640081000982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081000983	active site
640081000984	phosphorylation site [posttranslational modification]
640081000985	intermolecular recognition site; other site
640081000986	dimerization interface [polypeptide binding]; other site
640081000987	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
640081000988	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
640081000989	Response regulator receiver domain; Region: Response_reg; pfam00072
640081000990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081000991	active site
640081000992	phosphorylation site [posttranslational modification]
640081000993	intermolecular recognition site; other site
640081000994	dimerization interface [polypeptide binding]; other site
640081000995	PAS domain S-box; Region: sensory_box; TIGR00229
640081000996	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081000997	putative active site [active]
640081000998	heme pocket [chemical binding]; other site
640081000999	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
640081001000	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
640081001001	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
640081001002	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
640081001003	alphaNTD homodimer interface [polypeptide binding]; other site
640081001004	alphaNTD - beta interaction site [polypeptide binding]; other site
640081001005	alphaNTD - beta' interaction site [polypeptide binding]; other site
640081001006	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
640081001007	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
640081001008	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
640081001009	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
640081001010	RNA binding surface [nucleotide binding]; other site
640081001011	30S ribosomal protein S11; Validated; Region: PRK05309
640081001012	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
640081001013	30S ribosomal protein S13; Region: bact_S13; TIGR03631
640081001014	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
640081001015	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
640081001016	rRNA binding site [nucleotide binding]; other site
640081001017	predicted 30S ribosome binding site; other site
640081001018	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
640081001019	SecY translocase; Region: SecY; pfam00344
640081001020	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
640081001021	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
640081001022	23S rRNA binding site [nucleotide binding]; other site
640081001023	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
640081001024	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
640081001025	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
640081001026	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
640081001027	5S rRNA interface [nucleotide binding]; other site
640081001028	23S rRNA interface [nucleotide binding]; other site
640081001029	L5 interface [polypeptide binding]; other site
640081001030	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
640081001031	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
640081001032	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
640081001033	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
640081001034	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
640081001035	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
640081001036	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
640081001037	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
640081001038	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
640081001039	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
640081001040	RNA binding site [nucleotide binding]; other site
640081001041	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
640081001042	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
640081001043	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
640081001044	23S rRNA interface [nucleotide binding]; other site
640081001045	putative translocon interaction site; other site
640081001046	signal recognition particle (SRP54) interaction site; other site
640081001047	L23 interface [polypeptide binding]; other site
640081001048	trigger factor interaction site; other site
640081001049	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
640081001050	23S rRNA interface [nucleotide binding]; other site
640081001051	5S rRNA interface [nucleotide binding]; other site
640081001052	putative antibiotic binding site [chemical binding]; other site
640081001053	L25 interface [polypeptide binding]; other site
640081001054	L27 interface [polypeptide binding]; other site
640081001055	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
640081001056	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
640081001057	G-X-X-G motif; other site
640081001058	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
640081001059	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
640081001060	putative translocon binding site; other site
640081001061	protein-rRNA interface [nucleotide binding]; other site
640081001062	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
640081001063	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
640081001064	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
640081001065	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
640081001066	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
640081001067	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
640081001068	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
640081001069	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
640081001070	elongation factor Tu; Reviewed; Region: PRK00049
640081001071	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
640081001072	G1 box; other site
640081001073	GEF interaction site [polypeptide binding]; other site
640081001074	GTP/Mg2+ binding site [chemical binding]; other site
640081001075	Switch I region; other site
640081001076	G2 box; other site
640081001077	G3 box; other site
640081001078	Switch II region; other site
640081001079	G4 box; other site
640081001080	G5 box; other site
640081001081	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
640081001082	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
640081001083	Antibiotic Binding Site [chemical binding]; other site
640081001084	elongation factor G; Reviewed; Region: PRK00007
640081001085	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
640081001086	G1 box; other site
640081001087	putative GEF interaction site [polypeptide binding]; other site
640081001088	GTP/Mg2+ binding site [chemical binding]; other site
640081001089	Switch I region; other site
640081001090	G2 box; other site
640081001091	G3 box; other site
640081001092	Switch II region; other site
640081001093	G4 box; other site
640081001094	G5 box; other site
640081001095	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
640081001096	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
640081001097	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
640081001098	30S ribosomal protein S7; Validated; Region: PRK05302
640081001099	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
640081001100	S17 interaction site [polypeptide binding]; other site
640081001101	S8 interaction site; other site
640081001102	16S rRNA interaction site [nucleotide binding]; other site
640081001103	streptomycin interaction site [chemical binding]; other site
640081001104	23S rRNA interaction site [nucleotide binding]; other site
640081001105	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
640081001106	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
640081001107	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
640081001108	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
640081001109	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
640081001110	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
640081001111	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
640081001112	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
640081001113	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
640081001114	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
640081001115	DNA binding site [nucleotide binding]
640081001116	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
640081001117	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
640081001118	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
640081001119	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
640081001120	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
640081001121	RPB3 interaction site [polypeptide binding]; other site
640081001122	RPB1 interaction site [polypeptide binding]; other site
640081001123	RPB11 interaction site [polypeptide binding]; other site
640081001124	RPB10 interaction site [polypeptide binding]; other site
640081001125	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
640081001126	core dimer interface [polypeptide binding]; other site
640081001127	peripheral dimer interface [polypeptide binding]; other site
640081001128	L10 interface [polypeptide binding]; other site
640081001129	L11 interface [polypeptide binding]; other site
640081001130	putative EF-Tu interaction site [polypeptide binding]; other site
640081001131	putative EF-G interaction site [polypeptide binding]; other site
640081001132	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
640081001133	23S rRNA interface [nucleotide binding]; other site
640081001134	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
640081001135	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
640081001136	mRNA/rRNA interface [nucleotide binding]; other site
640081001137	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
640081001138	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
640081001139	23S rRNA interface [nucleotide binding]; other site
640081001140	L7/L12 interface [polypeptide binding]; other site
640081001141	putative thiostrepton binding site; other site
640081001142	L25 interface [polypeptide binding]; other site
640081001143	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
640081001144	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
640081001145	putative homodimer interface [polypeptide binding]; other site
640081001146	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
640081001147	heterodimer interface [polypeptide binding]; other site
640081001148	homodimer interface [polypeptide binding]; other site
640081001149	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
640081001150	elongation factor Tu; Reviewed; Region: PRK00049
640081001151	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
640081001152	G1 box; other site
640081001153	GEF interaction site [polypeptide binding]; other site
640081001154	GTP/Mg2+ binding site [chemical binding]; other site
640081001155	Switch I region; other site
640081001156	G2 box; other site
640081001157	G3 box; other site
640081001158	Switch II region; other site
640081001159	G4 box; other site
640081001160	G5 box; other site
640081001161	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
640081001162	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
640081001163	Antibiotic Binding Site [chemical binding]; other site
640081001164	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
640081001165	FAD binding domain; Region: FAD_binding_4; pfam01565
640081001166	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
640081001167	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
640081001168	dimer interface [polypeptide binding]; other site
640081001169	PYR/PP interface [polypeptide binding]; other site
640081001170	TPP binding site [chemical binding]; other site
640081001171	substrate binding site [chemical binding]; other site
640081001172	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
640081001173	TPP-binding site; other site
640081001174	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
640081001175	Methyltransferase domain; Region: Methyltransf_18; pfam12847
640081001176	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081001177	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081001178	dimerization interface [polypeptide binding]; other site
640081001179	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081001180	dimer interface [polypeptide binding]; other site
640081001181	phosphorylation site [posttranslational modification]
640081001182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081001183	ATP binding site [chemical binding]; other site
640081001184	Mg2+ binding site [ion binding]; other site
640081001185	G-X-G motif; other site
640081001186	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
640081001187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081001188	active site
640081001189	phosphorylation site [posttranslational modification]
640081001190	intermolecular recognition site; other site
640081001191	dimerization interface [polypeptide binding]; other site
640081001192	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
640081001193	DNA binding residues [nucleotide binding]
640081001194	dimerization interface [polypeptide binding]; other site
640081001195	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
640081001196	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
640081001197	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
640081001198	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
640081001199	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
640081001200	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
640081001201	catalytic residues [active]
640081001202	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
640081001203	Dehydroquinase class II; Region: DHquinase_II; pfam01220
640081001204	active site
640081001205	trimer interface [polypeptide binding]; other site
640081001206	dimer interface [polypeptide binding]; other site
640081001207	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
640081001208	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
640081001209	carboxyltransferase (CT) interaction site; other site
640081001210	biotinylation site [posttranslational modification]; other site
640081001211	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
640081001212	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
640081001213	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
640081001214	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
640081001215	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
640081001216	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
640081001217	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
640081001218	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
640081001219	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
640081001220	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
640081001221	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
640081001222	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
640081001223	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
640081001224	substrate binding site [chemical binding]; other site
640081001225	ATP binding site [chemical binding]; other site
640081001226	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
640081001227	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
640081001228	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
640081001229	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
640081001230	putative acyl-acceptor binding pocket; other site
640081001231	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
640081001232	UDP-glucose 4-epimerase; Region: PLN02240
640081001233	NAD binding site [chemical binding]; other site
640081001234	homodimer interface [polypeptide binding]; other site
640081001235	active site
640081001236	substrate binding site [chemical binding]; other site
640081001237	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
640081001238	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
640081001239	active site
640081001240	metal binding site [ion binding]; metal-binding site
640081001241	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
640081001242	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
640081001243	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
640081001244	NAD(P) binding site [chemical binding]; other site
640081001245	homodimer interface [polypeptide binding]; other site
640081001246	substrate binding site [chemical binding]; other site
640081001247	active site
640081001248	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
640081001249	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
640081001250	putative NAD(P) binding site [chemical binding]; other site
640081001251	active site
640081001252	putative substrate binding site [chemical binding]; other site
640081001253	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
640081001254	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
640081001255	putative metal binding site; other site
640081001256	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
640081001257	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
640081001258	putative active site [active]
640081001259	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
640081001260	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
640081001261	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
640081001262	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
640081001263	active site residue [active]
640081001264	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
640081001265	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081001266	S-adenosylmethionine binding site [chemical binding]; other site
640081001267	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
640081001268	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
640081001269	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
640081001270	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081001271	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
640081001272	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
640081001273	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
640081001274	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
640081001275	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
640081001276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081001277	dimer interface [polypeptide binding]; other site
640081001278	conserved gate region; other site
640081001279	putative PBP binding loops; other site
640081001280	ABC-ATPase subunit interface; other site
640081001281	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
640081001282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081001283	dimer interface [polypeptide binding]; other site
640081001284	conserved gate region; other site
640081001285	putative PBP binding loops; other site
640081001286	ABC-ATPase subunit interface; other site
640081001287	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
640081001288	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
640081001289	Walker A/P-loop; other site
640081001290	ATP binding site [chemical binding]; other site
640081001291	Q-loop/lid; other site
640081001292	ABC transporter signature motif; other site
640081001293	Walker B; other site
640081001294	D-loop; other site
640081001295	H-loop/switch region; other site
640081001296	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
640081001297	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
640081001298	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
640081001299	Walker A/P-loop; other site
640081001300	ATP binding site [chemical binding]; other site
640081001301	Q-loop/lid; other site
640081001302	ABC transporter signature motif; other site
640081001303	Walker B; other site
640081001304	D-loop; other site
640081001305	H-loop/switch region; other site
640081001306	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
640081001307	Transcriptional regulators [Transcription]; Region: FadR; COG2186
640081001308	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
640081001309	DNA-binding site [nucleotide binding]; DNA binding site
640081001310	FCD domain; Region: FCD; pfam07729
640081001311	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
640081001312	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
640081001313	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
640081001314	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
640081001315	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
640081001316	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
640081001317	DNA-binding site [nucleotide binding]; DNA binding site
640081001318	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081001319	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081001320	homodimer interface [polypeptide binding]; other site
640081001321	catalytic residue [active]
640081001322	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
640081001323	active site
640081001324	zinc binding site [ion binding]; other site
640081001325	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
640081001326	ThiC-associated domain; Region: ThiC-associated; pfam13667
640081001327	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
640081001328	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
640081001329	XFP N-terminal domain; Region: XFP_N; pfam09364
640081001330	putative phosphoketolase; Provisional; Region: PRK05261
640081001331	XFP C-terminal domain; Region: XFP_C; pfam09363
640081001332	Flagellin N-methylase; Region: FliB; pfam03692
640081001333	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081001334	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081001335	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
640081001336	putative effector binding pocket; other site
640081001337	dimerization interface [polypeptide binding]; other site
640081001338	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
640081001339	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
640081001340	active site
640081001341	FMN binding site [chemical binding]; other site
640081001342	substrate binding site [chemical binding]; other site
640081001343	homotetramer interface [polypeptide binding]; other site
640081001344	catalytic residue [active]
640081001345	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081001346	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081001347	dimerization interface [polypeptide binding]; other site
640081001348	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081001349	dimer interface [polypeptide binding]; other site
640081001350	putative CheW interface [polypeptide binding]; other site
640081001351	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
640081001352	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
640081001353	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
640081001354	catalytic residue [active]
640081001355	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
640081001356	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
640081001357	putative ligand binding site [chemical binding]; other site
640081001358	EamA-like transporter family; Region: EamA; pfam00892
640081001359	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
640081001360	putative protease; Provisional; Region: PRK15452
640081001361	Peptidase family U32; Region: Peptidase_U32; pfam01136
640081001362	ribonuclease G; Provisional; Region: PRK11712
640081001363	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
640081001364	homodimer interface [polypeptide binding]; other site
640081001365	oligonucleotide binding site [chemical binding]; other site
640081001366	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
640081001367	Sel1-like repeats; Region: SEL1; smart00671
640081001368	Sel1 repeat; Region: Sel1; cl02723
640081001369	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
640081001370	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
640081001371	succinic semialdehyde dehydrogenase; Region: PLN02278
640081001372	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
640081001373	tetramerization interface [polypeptide binding]; other site
640081001374	NAD(P) binding site [chemical binding]; other site
640081001375	catalytic residues [active]
640081001376	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
640081001377	NlpC/P60 family; Region: NLPC_P60; pfam00877
640081001378	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
640081001379	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
640081001380	FMN binding site [chemical binding]; other site
640081001381	substrate binding site [chemical binding]; other site
640081001382	putative catalytic residue [active]
640081001383	HDOD domain; Region: HDOD; pfam08668
640081001384	HD domain; Region: HD; pfam01966
640081001385	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
640081001386	MgtE intracellular N domain; Region: MgtE_N; smart00924
640081001387	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
640081001388	Divalent cation transporter; Region: MgtE; cl00786
640081001389	Transglycosylase; Region: Transgly; cl17702
640081001390	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
640081001391	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
640081001392	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
640081001393	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
640081001394	NAD(P) binding site [chemical binding]; other site
640081001395	shikimate binding site; other site
640081001396	Hemerythrin; Region: Hemerythrin; cd12107
640081001397	Fe binding site [ion binding]; other site
640081001398	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
640081001399	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
640081001400	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
640081001401	RNB domain; Region: RNB; pfam00773
640081001402	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
640081001403	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
640081001404	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
640081001405	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
640081001406	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
640081001407	active site
640081001408	dimer interface [polypeptide binding]; other site
640081001409	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
640081001410	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
640081001411	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
640081001412	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
640081001413	active site
640081001414	(T/H)XGH motif; other site
640081001415	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
640081001416	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
640081001417	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
640081001418	putative active site [active]
640081001419	putative substrate binding site [chemical binding]; other site
640081001420	ATP binding site [chemical binding]; other site
640081001421	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
640081001422	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
640081001423	DNA polymerase I; Provisional; Region: PRK05755
640081001424	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
640081001425	active site
640081001426	metal binding site 1 [ion binding]; metal-binding site
640081001427	putative 5' ssDNA interaction site; other site
640081001428	metal binding site 3; metal-binding site
640081001429	metal binding site 2 [ion binding]; metal-binding site
640081001430	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
640081001431	putative DNA binding site [nucleotide binding]; other site
640081001432	putative metal binding site [ion binding]; other site
640081001433	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
640081001434	active site
640081001435	catalytic site [active]
640081001436	substrate binding site [chemical binding]; other site
640081001437	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
640081001438	active site
640081001439	DNA binding site [nucleotide binding]
640081001440	catalytic site [active]
640081001441	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
640081001442	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
640081001443	putative active site [active]
640081001444	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
640081001445	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
640081001446	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
640081001447	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
640081001448	putative active site [active]
640081001449	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
640081001450	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
640081001451	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
640081001452	putative active site [active]
640081001453	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
640081001454	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
640081001455	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
640081001456	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
640081001457	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
640081001458	Walker A/P-loop; other site
640081001459	ATP binding site [chemical binding]; other site
640081001460	Q-loop/lid; other site
640081001461	ABC transporter signature motif; other site
640081001462	Walker B; other site
640081001463	D-loop; other site
640081001464	H-loop/switch region; other site
640081001465	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
640081001466	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
640081001467	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
640081001468	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
640081001469	putative active site [active]
640081001470	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
640081001471	catalytic core [active]
640081001472	cobalamin synthase; Reviewed; Region: cobS; PRK00235
640081001473	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
640081001474	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
640081001475	putative dimer interface [polypeptide binding]; other site
640081001476	active site pocket [active]
640081001477	putative cataytic base [active]
640081001478	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
640081001479	homotrimer interface [polypeptide binding]; other site
640081001480	Walker A motif; other site
640081001481	GTP binding site [chemical binding]; other site
640081001482	Walker B motif; other site
640081001483	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
640081001484	Ligand Binding Site [chemical binding]; other site
640081001485	PilZ domain; Region: PilZ; pfam07238
640081001486	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
640081001487	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081001488	FeS/SAM binding site; other site
640081001489	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
640081001490	Tetratricopeptide repeat; Region: TPR_6; pfam13174
640081001491	putative outer membrane lipoprotein; Provisional; Region: PRK09967
640081001492	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
640081001493	ligand binding site [chemical binding]; other site
640081001494	translocation protein TolB; Provisional; Region: tolB; PRK02889
640081001495	TolB amino-terminal domain; Region: TolB_N; pfam04052
640081001496	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
640081001497	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
640081001498	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
640081001499	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
640081001500	TolA protein; Region: tolA_full; TIGR02794
640081001501	TonB C terminal; Region: TonB_2; pfam13103
640081001502	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
640081001503	TolR protein; Region: tolR; TIGR02801
640081001504	TolQ protein; Region: tolQ; TIGR02796
640081001505	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
640081001506	active site
640081001507	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
640081001508	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081001509	Walker A motif; other site
640081001510	ATP binding site [chemical binding]; other site
640081001511	Walker B motif; other site
640081001512	arginine finger; other site
640081001513	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
640081001514	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
640081001515	RuvA N terminal domain; Region: RuvA_N; pfam01330
640081001516	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
640081001517	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
640081001518	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
640081001519	active site
640081001520	putative DNA-binding cleft [nucleotide binding]; other site
640081001521	dimer interface [polypeptide binding]; other site
640081001522	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
640081001523	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
640081001524	hypothetical protein; Validated; Region: PRK00110
640081001525	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
640081001526	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
640081001527	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081001528	FeS/SAM binding site; other site
640081001529	HemN C-terminal domain; Region: HemN_C; pfam06969
640081001530	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
640081001531	active site
640081001532	dimerization interface [polypeptide binding]; other site
640081001533	ribonuclease PH; Reviewed; Region: rph; PRK00173
640081001534	Ribonuclease PH; Region: RNase_PH_bact; cd11362
640081001535	hexamer interface [polypeptide binding]; other site
640081001536	active site
640081001537	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
640081001538	active site
640081001539	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
640081001540	Catalytic domain of Protein Kinases; Region: PKc; cd00180
640081001541	active site
640081001542	ATP binding site [chemical binding]; other site
640081001543	substrate binding site [chemical binding]; other site
640081001544	activation loop (A-loop); other site
640081001545	hypothetical protein; Provisional; Region: PRK11820
640081001546	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
640081001547	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
640081001548	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
640081001549	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
640081001550	catalytic site [active]
640081001551	G-X2-G-X-G-K; other site
640081001552	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
640081001553	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
640081001554	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081001555	Zn2+ binding site [ion binding]; other site
640081001556	Mg2+ binding site [ion binding]; other site
640081001557	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
640081001558	synthetase active site [active]
640081001559	NTP binding site [chemical binding]; other site
640081001560	metal binding site [ion binding]; metal-binding site
640081001561	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
640081001562	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
640081001563	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
640081001564	enoyl-CoA hydratase; Provisional; Region: PRK06688
640081001565	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
640081001566	substrate binding site [chemical binding]; other site
640081001567	oxyanion hole (OAH) forming residues; other site
640081001568	trimer interface [polypeptide binding]; other site
640081001569	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
640081001570	active site
640081001571	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
640081001572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
640081001573	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
640081001574	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
640081001575	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081001576	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081001577	metal binding site [ion binding]; metal-binding site
640081001578	active site
640081001579	I-site; other site
640081001580	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081001581	NapD protein; Region: NapD; pfam03927
640081001582	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
640081001583	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
640081001584	[4Fe-4S] binding site [ion binding]; other site
640081001585	molybdopterin cofactor binding site; other site
640081001586	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
640081001587	molybdopterin cofactor binding site; other site
640081001588	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
640081001589	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
640081001590	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
640081001591	4Fe-4S binding domain; Region: Fer4_5; pfam12801
640081001592	4Fe-4S binding domain; Region: Fer4_5; pfam12801
640081001593	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
640081001594	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
640081001595	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
640081001596	dimer interface [polypeptide binding]; other site
640081001597	substrate binding site [chemical binding]; other site
640081001598	metal binding site [ion binding]; metal-binding site
640081001599	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
640081001600	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
640081001601	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081001602	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081001603	metal binding site [ion binding]; metal-binding site
640081001604	active site
640081001605	I-site; other site
640081001606	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
640081001607	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
640081001608	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
640081001609	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
640081001610	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
640081001611	carboxyltransferase (CT) interaction site; other site
640081001612	biotinylation site [posttranslational modification]; other site
640081001613	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
640081001614	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
640081001615	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
640081001616	membrane ATPase/protein kinase; Provisional; Region: PRK09435
640081001617	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
640081001618	Walker A; other site
640081001619	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
640081001620	G4 box; other site
640081001621	G5 box; other site
640081001622	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
640081001623	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
640081001624	active site
640081001625	substrate binding site [chemical binding]; other site
640081001626	coenzyme B12 binding site [chemical binding]; other site
640081001627	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
640081001628	B12 binding site [chemical binding]; other site
640081001629	cobalt ligand [ion binding]; other site
640081001630	Transcriptional regulators [Transcription]; Region: FadR; COG2186
640081001631	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
640081001632	DNA-binding site [nucleotide binding]; DNA binding site
640081001633	FCD domain; Region: FCD; pfam07729
640081001634	enoyl-CoA hydratase; Provisional; Region: PRK06127
640081001635	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
640081001636	substrate binding site [chemical binding]; other site
640081001637	oxyanion hole (OAH) forming residues; other site
640081001638	trimer interface [polypeptide binding]; other site
640081001639	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
640081001640	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
640081001641	Na binding site [ion binding]; other site
640081001642	Protein of unknown function, DUF485; Region: DUF485; pfam04341
640081001643	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
640081001644	EVE domain; Region: EVE; cl00728
640081001645	Cell division protein ZapA; Region: ZapA; pfam05164
640081001646	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
640081001647	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081001648	N-terminal plug; other site
640081001649	ligand-binding site [chemical binding]; other site
640081001650	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
640081001651	ABC-ATPase subunit  interface; other site
640081001652	dimer interface [polypeptide binding]; other site
640081001653	putative PBP binding regions; other site
640081001654	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
640081001655	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
640081001656	Walker A/P-loop; other site
640081001657	ATP binding site [chemical binding]; other site
640081001658	Q-loop/lid; other site
640081001659	ABC transporter signature motif; other site
640081001660	Walker B; other site
640081001661	D-loop; other site
640081001662	H-loop/switch region; other site
640081001663	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
640081001664	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
640081001665	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
640081001666	homodimer interface [polypeptide binding]; other site
640081001667	Walker A motif; other site
640081001668	ATP binding site [chemical binding]; other site
640081001669	hydroxycobalamin binding site [chemical binding]; other site
640081001670	Walker B motif; other site
640081001671	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
640081001672	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
640081001673	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
640081001674	catalytic triad [active]
640081001675	Hemerythrin; Region: Hemerythrin; cd12107
640081001676	Fe binding site [ion binding]; other site
640081001677	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081001678	ATP binding site [chemical binding]; other site
640081001679	Mg2+ binding site [ion binding]; other site
640081001680	G-X-G motif; other site
640081001681	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
640081001682	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
640081001683	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
640081001684	cobalamin binding residues [chemical binding]; other site
640081001685	putative BtuC binding residues; other site
640081001686	dimer interface [polypeptide binding]; other site
640081001687	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
640081001688	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
640081001689	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
640081001690	catalytic residue [active]
640081001691	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
640081001692	cobyric acid synthase; Provisional; Region: PRK00784
640081001693	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
640081001694	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
640081001695	catalytic triad [active]
640081001696	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
640081001697	Malic enzyme, N-terminal domain; Region: malic; pfam00390
640081001698	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
640081001699	putative NAD(P) binding site [chemical binding]; other site
640081001700	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
640081001701	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
640081001702	Predicted transporter component [General function prediction only]; Region: COG2391
640081001703	Sulphur transport; Region: Sulf_transp; pfam04143
640081001704	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
640081001705	Ligand Binding Site [chemical binding]; other site
640081001706	nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478
640081001707	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
640081001708	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
640081001709	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
640081001710	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
640081001711	probable nitrogen fixation protein; Region: TIGR02935
640081001712	Rop-like; Region: Rop-like; pfam05082
640081001713	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
640081001714	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
640081001715	NifQ; Region: NifQ; pfam04891
640081001716	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
640081001717	TPR repeat; Region: TPR_11; pfam13414
640081001718	binding surface
640081001719	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081001720	TPR repeat; Region: TPR_11; pfam13414
640081001721	TPR motif; other site
640081001722	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
640081001723	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
640081001724	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
640081001725	PhnA protein; Region: PhnA; pfam03831
640081001726	molybdenum-pterin binding domain; Region: Mop; TIGR00638
640081001727	molybdenum-pterin binding domain; Region: Mop; TIGR00638
640081001728	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
640081001729	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
640081001730	molybdenum-pterin binding domain; Region: Mop; TIGR00638
640081001731	molybdenum-pterin binding domain; Region: Mop; TIGR00638
640081001732	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
640081001733	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
640081001734	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
640081001735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081001736	dimer interface [polypeptide binding]; other site
640081001737	conserved gate region; other site
640081001738	putative PBP binding loops; other site
640081001739	ABC-ATPase subunit interface; other site
640081001740	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
640081001741	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081001742	Walker A/P-loop; other site
640081001743	ATP binding site [chemical binding]; other site
640081001744	Q-loop/lid; other site
640081001745	ABC transporter signature motif; other site
640081001746	Walker B; other site
640081001747	D-loop; other site
640081001748	H-loop/switch region; other site
640081001749	TOBE domain; Region: TOBE; cl01440
640081001750	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
640081001751	putative molybdenum utilization protein ModD; Region: modD; TIGR01334
640081001752	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
640081001753	dimerization interface [polypeptide binding]; other site
640081001754	active site
640081001755	TOBE domain; Region: TOBE; cl01440
640081001756	TOBE domain; Region: TOBE; cl01440
640081001757	PAS domain S-box; Region: sensory_box; TIGR00229
640081001758	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081001759	putative active site [active]
640081001760	heme pocket [chemical binding]; other site
640081001761	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081001762	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081001763	metal binding site [ion binding]; metal-binding site
640081001764	active site
640081001765	I-site; other site
640081001766	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
640081001767	dimer interface [polypeptide binding]; other site
640081001768	[2Fe-2S] cluster binding site [ion binding]; other site
640081001769	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
640081001770	Ferritin-like domain; Region: Ferritin; pfam00210
640081001771	diiron binding motif [ion binding]; other site
640081001772	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
640081001773	oxidoreductase; Provisional; Region: PRK10015
640081001774	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
640081001775	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
640081001776	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
640081001777	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
640081001778	Ligand binding site [chemical binding]; other site
640081001779	Electron transfer flavoprotein domain; Region: ETF; pfam01012
640081001780	Nitrogen fixation protein NifW; Region: NifW; pfam03206
640081001781	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
640081001782	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
640081001783	active site
640081001784	catalytic residues [active]
640081001785	metal binding site [ion binding]; metal-binding site
640081001786	Membrane transport protein; Region: Mem_trans; cl09117
640081001787	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
640081001788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081001789	Walker A motif; other site
640081001790	ATP binding site [chemical binding]; other site
640081001791	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081001792	Walker B motif; other site
640081001793	arginine finger; other site
640081001794	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
640081001795	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
640081001796	active site
640081001797	HslU subunit interaction site [polypeptide binding]; other site
640081001798	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
640081001799	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
640081001800	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
640081001801	Walker A/P-loop; other site
640081001802	ATP binding site [chemical binding]; other site
640081001803	Q-loop/lid; other site
640081001804	ABC transporter signature motif; other site
640081001805	Walker B; other site
640081001806	D-loop; other site
640081001807	H-loop/switch region; other site
640081001808	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
640081001809	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
640081001810	intersubunit interface [polypeptide binding]; other site
640081001811	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
640081001812	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
640081001813	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
640081001814	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
640081001815	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
640081001816	P-loop, Walker A motif; other site
640081001817	Base recognition motif; other site
640081001818	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
640081001819	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
640081001820	metal binding site 2 [ion binding]; metal-binding site
640081001821	putative DNA binding helix; other site
640081001822	metal binding site 1 [ion binding]; metal-binding site
640081001823	dimer interface [polypeptide binding]; other site
640081001824	structural Zn2+ binding site [ion binding]; other site
640081001825	DNA photolyase; Region: DNA_photolyase; pfam00875
640081001826	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
640081001827	Protein of unknown function (DUF342); Region: DUF342; pfam03961
640081001828	hypothetical protein; Validated; Region: PRK00228
640081001829	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
640081001830	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
640081001831	active site
640081001832	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
640081001833	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
640081001834	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
640081001835	dihydroorotase; Provisional; Region: PRK07627
640081001836	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
640081001837	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
640081001838	active site
640081001839	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081001840	putative active site [active]
640081001841	heme pocket [chemical binding]; other site
640081001842	LytTr DNA-binding domain; Region: LytTR; smart00850
640081001843	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
640081001844	YGGT family; Region: YGGT; pfam02325
640081001845	YGGT family; Region: YGGT; pfam02325
640081001846	pyrroline-5-carboxylate reductase; Region: PLN02688
640081001847	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
640081001848	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
640081001849	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
640081001850	catalytic residue [active]
640081001851	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
640081001852	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
640081001853	Walker A motif; other site
640081001854	ATP binding site [chemical binding]; other site
640081001855	Walker B motif; other site
640081001856	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
640081001857	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
640081001858	Walker A motif; other site
640081001859	ATP binding site [chemical binding]; other site
640081001860	Walker B motif; other site
640081001861	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
640081001862	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
640081001863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
640081001864	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
640081001865	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
640081001866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
640081001867	NAD(P) binding site [chemical binding]; other site
640081001868	active site
640081001869	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
640081001870	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
640081001871	catalytic loop [active]
640081001872	iron binding site [ion binding]; other site
640081001873	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
640081001874	FAD binding pocket [chemical binding]; other site
640081001875	FAD binding motif [chemical binding]; other site
640081001876	phosphate binding motif [ion binding]; other site
640081001877	beta-alpha-beta structure motif; other site
640081001878	NAD binding pocket [chemical binding]; other site
640081001879	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
640081001880	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
640081001881	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
640081001882	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081001883	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
640081001884	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
640081001885	Cu(I) binding site [ion binding]; other site
640081001886	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
640081001887	FtsX-like permease family; Region: FtsX; pfam02687
640081001888	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
640081001889	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
640081001890	Walker A/P-loop; other site
640081001891	ATP binding site [chemical binding]; other site
640081001892	Q-loop/lid; other site
640081001893	ABC transporter signature motif; other site
640081001894	Walker B; other site
640081001895	D-loop; other site
640081001896	H-loop/switch region; other site
640081001897	NosL; Region: NosL; cl01769
640081001898	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
640081001899	Secretin and TonB N terminus short domain; Region: STN; smart00965
640081001900	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081001901	N-terminal plug; other site
640081001902	ligand-binding site [chemical binding]; other site
640081001903	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
640081001904	FecR protein; Region: FecR; pfam04773
640081001905	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
640081001906	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081001907	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081001908	DNA binding residues [nucleotide binding]
640081001909	NosL; Region: NosL; cl01769
640081001910	NosL; Region: NosL; cl01769
640081001911	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
640081001912	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
640081001913	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
640081001914	Walker A/P-loop; other site
640081001915	ATP binding site [chemical binding]; other site
640081001916	Q-loop/lid; other site
640081001917	ABC transporter signature motif; other site
640081001918	Walker B; other site
640081001919	D-loop; other site
640081001920	H-loop/switch region; other site
640081001921	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
640081001922	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
640081001923	Walker A/P-loop; other site
640081001924	ATP binding site [chemical binding]; other site
640081001925	Q-loop/lid; other site
640081001926	ABC transporter signature motif; other site
640081001927	Walker B; other site
640081001928	D-loop; other site
640081001929	H-loop/switch region; other site
640081001930	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
640081001931	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
640081001932	TM-ABC transporter signature motif; other site
640081001933	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
640081001934	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
640081001935	TM-ABC transporter signature motif; other site
640081001936	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
640081001937	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
640081001938	dimerization interface [polypeptide binding]; other site
640081001939	ligand binding site [chemical binding]; other site
640081001940	Cytochrome c; Region: Cytochrom_C; cl11414
640081001941	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
640081001942	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
640081001943	catalytic residues [active]
640081001944	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081001945	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081001946	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
640081001947	putative dimerization interface [polypeptide binding]; other site
640081001948	EamA-like transporter family; Region: EamA; pfam00892
640081001949	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
640081001950	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
640081001951	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
640081001952	substrate binding pocket [chemical binding]; other site
640081001953	membrane-bound complex binding site; other site
640081001954	hinge residues; other site
640081001955	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
640081001956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081001957	dimer interface [polypeptide binding]; other site
640081001958	conserved gate region; other site
640081001959	putative PBP binding loops; other site
640081001960	ABC-ATPase subunit interface; other site
640081001961	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081001962	dimer interface [polypeptide binding]; other site
640081001963	conserved gate region; other site
640081001964	putative PBP binding loops; other site
640081001965	ABC-ATPase subunit interface; other site
640081001966	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
640081001967	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
640081001968	Walker A/P-loop; other site
640081001969	ATP binding site [chemical binding]; other site
640081001970	Q-loop/lid; other site
640081001971	ABC transporter signature motif; other site
640081001972	Walker B; other site
640081001973	D-loop; other site
640081001974	H-loop/switch region; other site
640081001975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
640081001976	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
640081001977	FAD binding site [chemical binding]; other site
640081001978	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
640081001979	RNA binding surface [nucleotide binding]; other site
640081001980	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
640081001981	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
640081001982	homotetramer interface [polypeptide binding]; other site
640081001983	ligand binding site [chemical binding]; other site
640081001984	catalytic site [active]
640081001985	NAD binding site [chemical binding]; other site
640081001986	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
640081001987	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
640081001988	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081001989	Zn2+ binding site [ion binding]; other site
640081001990	Mg2+ binding site [ion binding]; other site
640081001991	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
640081001992	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
640081001993	acyl-activating enzyme (AAE) consensus motif; other site
640081001994	AMP binding site [chemical binding]; other site
640081001995	active site
640081001996	CoA binding site [chemical binding]; other site
640081001997	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
640081001998	S-adenosylmethionine synthetase; Validated; Region: PRK05250
640081001999	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
640081002000	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
640081002001	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
640081002002	putative acyl-acceptor binding pocket; other site
640081002003	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
640081002004	putative acyl-acceptor binding pocket; other site
640081002005	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
640081002006	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
640081002007	Coenzyme A binding pocket [chemical binding]; other site
640081002008	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
640081002009	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
640081002010	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
640081002011	Protein of unknown function, DUF484; Region: DUF484; cl17449
640081002012	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
640081002013	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
640081002014	active site
640081002015	DNA binding site [nucleotide binding]
640081002016	Int/Topo IB signature motif; other site
640081002017	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
640081002018	dinuclear metal binding motif [ion binding]; other site
640081002019	CCC1-related family of proteins; Region: CCC1_like; cl00278
640081002020	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
640081002021	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
640081002022	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
640081002023	putative RNA binding site [nucleotide binding]; other site
640081002024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081002025	S-adenosylmethionine binding site [chemical binding]; other site
640081002026	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
640081002027	Hpt domain; Region: Hpt; pfam01627
640081002028	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
640081002029	putative binding surface; other site
640081002030	active site
640081002031	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
640081002032	putative binding surface; other site
640081002033	active site
640081002034	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
640081002035	putative binding surface; other site
640081002036	active site
640081002037	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
640081002038	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
640081002039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081002040	ATP binding site [chemical binding]; other site
640081002041	Mg2+ binding site [ion binding]; other site
640081002042	G-X-G motif; other site
640081002043	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
640081002044	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
640081002045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081002046	active site
640081002047	phosphorylation site [posttranslational modification]
640081002048	intermolecular recognition site; other site
640081002049	dimerization interface [polypeptide binding]; other site
640081002050	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
640081002051	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081002052	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081002053	dimer interface [polypeptide binding]; other site
640081002054	putative CheW interface [polypeptide binding]; other site
640081002055	CheW-like domain; Region: CheW; pfam01584
640081002056	Response regulator receiver domain; Region: Response_reg; pfam00072
640081002057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081002058	active site
640081002059	phosphorylation site [posttranslational modification]
640081002060	intermolecular recognition site; other site
640081002061	dimerization interface [polypeptide binding]; other site
640081002062	Response regulator receiver domain; Region: Response_reg; pfam00072
640081002063	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081002064	active site
640081002065	phosphorylation site [posttranslational modification]
640081002066	intermolecular recognition site; other site
640081002067	dimerization interface [polypeptide binding]; other site
640081002068	Rubredoxin [Energy production and conversion]; Region: COG1773
640081002069	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
640081002070	iron binding site [ion binding]; other site
640081002071	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
640081002072	dimer interface [polypeptide binding]; other site
640081002073	substrate binding site [chemical binding]; other site
640081002074	ATP binding site [chemical binding]; other site
640081002075	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
640081002076	thiamine phosphate binding site [chemical binding]; other site
640081002077	active site
640081002078	pyrophosphate binding site [ion binding]; other site
640081002079	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
640081002080	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
640081002081	inhibitor-cofactor binding pocket; inhibition site
640081002082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081002083	catalytic residue [active]
640081002084	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
640081002085	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
640081002086	Na binding site [ion binding]; other site
640081002087	putative glycosylation site [posttranslational modification]; other site
640081002088	putative glycosylation site [posttranslational modification]; other site
640081002089	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
640081002090	Arginase family; Region: Arginase; cd09989
640081002091	active site
640081002092	Mn binding site [ion binding]; other site
640081002093	oligomer interface [polypeptide binding]; other site
640081002094	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
640081002095	ABC1 family; Region: ABC1; pfam03109
640081002096	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
640081002097	active site
640081002098	ATP binding site [chemical binding]; other site
640081002099	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
640081002100	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
640081002101	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
640081002102	active site
640081002103	HIGH motif; other site
640081002104	KMSK motif region; other site
640081002105	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
640081002106	tRNA binding surface [nucleotide binding]; other site
640081002107	anticodon binding site; other site
640081002108	Sporulation related domain; Region: SPOR; pfam05036
640081002109	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
640081002110	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
640081002111	catalytic residues [active]
640081002112	hinge region; other site
640081002113	alpha helical domain; other site
640081002114	short chain dehydrogenase; Provisional; Region: PRK07024
640081002115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
640081002116	NAD(P) binding site [chemical binding]; other site
640081002117	active site
640081002118	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
640081002119	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
640081002120	Cu(I) binding site [ion binding]; other site
640081002121	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
640081002122	NAD(P) binding site [chemical binding]; other site
640081002123	active site
640081002124	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
640081002125	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
640081002126	intersubunit interface [polypeptide binding]; other site
640081002127	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
640081002128	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
640081002129	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
640081002130	N-acetyl-D-glucosamine binding site [chemical binding]; other site
640081002131	catalytic residue [active]
640081002132	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
640081002133	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
640081002134	putative NAD(P) binding site [chemical binding]; other site
640081002135	active site
640081002136	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
640081002137	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
640081002138	putative C-terminal domain interface [polypeptide binding]; other site
640081002139	putative GSH binding site (G-site) [chemical binding]; other site
640081002140	putative dimer interface [polypeptide binding]; other site
640081002141	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
640081002142	putative N-terminal domain interface [polypeptide binding]; other site
640081002143	putative dimer interface [polypeptide binding]; other site
640081002144	putative substrate binding pocket (H-site) [chemical binding]; other site
640081002145	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
640081002146	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
640081002147	active site
640081002148	NTP binding site [chemical binding]; other site
640081002149	metal binding triad [ion binding]; metal-binding site
640081002150	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
640081002151	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081002152	Zn2+ binding site [ion binding]; other site
640081002153	Mg2+ binding site [ion binding]; other site
640081002154	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
640081002155	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
640081002156	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
640081002157	C-terminal domain interface [polypeptide binding]; other site
640081002158	GSH binding site (G-site) [chemical binding]; other site
640081002159	dimer interface [polypeptide binding]; other site
640081002160	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
640081002161	N-terminal domain interface [polypeptide binding]; other site
640081002162	putative dimer interface [polypeptide binding]; other site
640081002163	active site
640081002164	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
640081002165	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
640081002166	Putative motility protein; Region: YjfB_motility; pfam14070
640081002167	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
640081002168	Uncharacterized conserved protein [Function unknown]; Region: COG1565
640081002169	pteridine reductase; Provisional; Region: PRK09135
640081002170	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
640081002171	NAD(P) binding site [chemical binding]; other site
640081002172	active site
640081002173	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
640081002174	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
640081002175	Ligand Binding Site [chemical binding]; other site
640081002176	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
640081002177	cyclase homology domain; Region: CHD; cd07302
640081002178	nucleotidyl binding site; other site
640081002179	metal binding site [ion binding]; metal-binding site
640081002180	dimer interface [polypeptide binding]; other site
640081002181	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
640081002182	phosphopeptide binding site; other site
640081002183	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
640081002184	Catalytic domain of Protein Kinases; Region: PKc; cd00180
640081002185	active site
640081002186	ATP binding site [chemical binding]; other site
640081002187	substrate binding site [chemical binding]; other site
640081002188	activation loop (A-loop); other site
640081002189	psiF repeat; Region: PsiF_repeat; pfam07769
640081002190	HPr kinase/phosphorylase; Provisional; Region: PRK05428
640081002191	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
640081002192	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
640081002193	Hpr binding site; other site
640081002194	active site
640081002195	homohexamer subunit interaction site [polypeptide binding]; other site
640081002196	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
640081002197	active site
640081002198	phosphorylation site [posttranslational modification]
640081002199	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
640081002200	30S subunit binding site; other site
640081002201	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
640081002202	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
640081002203	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
640081002204	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
640081002205	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
640081002206	Walker A/P-loop; other site
640081002207	ATP binding site [chemical binding]; other site
640081002208	Q-loop/lid; other site
640081002209	ABC transporter signature motif; other site
640081002210	Walker B; other site
640081002211	D-loop; other site
640081002212	H-loop/switch region; other site
640081002213	recombination regulator RecX; Reviewed; Region: recX; PRK00117
640081002214	recombinase A; Provisional; Region: recA; PRK09354
640081002215	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
640081002216	hexamer interface [polypeptide binding]; other site
640081002217	Walker A motif; other site
640081002218	ATP binding site [chemical binding]; other site
640081002219	Walker B motif; other site
640081002220	PAS domain; Region: PAS; smart00091
640081002221	PAS fold; Region: PAS_3; pfam08447
640081002222	PAS fold; Region: PAS_3; pfam08447
640081002223	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081002224	heme pocket [chemical binding]; other site
640081002225	putative active site [active]
640081002226	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081002227	PAS domain; Region: PAS_9; pfam13426
640081002228	putative active site [active]
640081002229	heme pocket [chemical binding]; other site
640081002230	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
640081002231	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
640081002232	heme binding site [chemical binding]; other site
640081002233	ferroxidase pore; other site
640081002234	ferroxidase diiron center [ion binding]; other site
640081002235	Competence-damaged protein; Region: CinA; pfam02464
640081002236	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
640081002237	tetramer interfaces [polypeptide binding]; other site
640081002238	binuclear metal-binding site [ion binding]; other site
640081002239	thiamine monophosphate kinase; Provisional; Region: PRK05731
640081002240	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
640081002241	ATP binding site [chemical binding]; other site
640081002242	dimerization interface [polypeptide binding]; other site
640081002243	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
640081002244	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
640081002245	homopentamer interface [polypeptide binding]; other site
640081002246	active site
640081002247	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
640081002248	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
640081002249	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
640081002250	dimerization interface [polypeptide binding]; other site
640081002251	active site
640081002252	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
640081002253	Lumazine binding domain; Region: Lum_binding; pfam00677
640081002254	Lumazine binding domain; Region: Lum_binding; pfam00677
640081002255	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
640081002256	dimerization interface [polypeptide binding]; other site
640081002257	active site
640081002258	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
640081002259	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
640081002260	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
640081002261	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
640081002262	DsbD alpha interface [polypeptide binding]; other site
640081002263	catalytic residues [active]
640081002264	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
640081002265	ABC-2 type transporter; Region: ABC2_membrane; cl17235
640081002266	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
640081002267	peptide-modifying radical SAM enzyme CbpB; Region: rSAM_cobopep; TIGR04163
640081002268	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081002269	FeS/SAM binding site; other site
640081002270	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
640081002271	modified peptide precursor CbpA; Region: cobo_pep; TIGR04164
640081002272	CheW-like domain; Region: CheW; pfam01584
640081002273	nodulation ABC transporter NodI; Provisional; Region: PRK13537
640081002274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081002275	Walker A/P-loop; other site
640081002276	ATP binding site [chemical binding]; other site
640081002277	Q-loop/lid; other site
640081002278	ABC transporter signature motif; other site
640081002279	Walker B; other site
640081002280	D-loop; other site
640081002281	H-loop/switch region; other site
640081002282	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
640081002283	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
640081002284	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
640081002285	dimer interface [polypeptide binding]; other site
640081002286	[2Fe-2S] cluster binding site [ion binding]; other site
640081002287	threonine dehydratase; Reviewed; Region: PRK09224
640081002288	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
640081002289	tetramer interface [polypeptide binding]; other site
640081002290	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081002291	catalytic residue [active]
640081002292	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
640081002293	putative Ile/Val binding site [chemical binding]; other site
640081002294	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
640081002295	putative Ile/Val binding site [chemical binding]; other site
640081002296	Autotransporter beta-domain; Region: Autotransporter; pfam03797
640081002297	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
640081002298	Phage Tail Collar Domain; Region: Collar; pfam07484
640081002299	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
640081002300	Phage Tail Collar Domain; Region: Collar; pfam07484
640081002301	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
640081002302	Phage Tail Collar Domain; Region: Collar; pfam07484
640081002303	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
640081002304	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
640081002305	Predicted membrane protein [Function unknown]; Region: COG1238
640081002306	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
640081002307	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
640081002308	FAD binding domain; Region: FAD_binding_4; pfam01565
640081002309	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
640081002310	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
640081002311	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
640081002312	Cysteine-rich domain; Region: CCG; pfam02754
640081002313	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
640081002314	Uncharacterized conserved protein [Function unknown]; Region: COG0432
640081002315	muropeptide transporter; Validated; Region: ampG; cl17669
640081002316	muropeptide transporter; Validated; Region: ampG; cl17669
640081002317	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081002318	S-adenosylmethionine binding site [chemical binding]; other site
640081002319	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
640081002320	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
640081002321	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
640081002322	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
640081002323	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
640081002324	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
640081002325	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
640081002326	dimerization domain swap beta strand [polypeptide binding]; other site
640081002327	regulatory protein interface [polypeptide binding]; other site
640081002328	active site
640081002329	regulatory phosphorylation site [posttranslational modification]; other site
640081002330	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
640081002331	active pocket/dimerization site; other site
640081002332	active site
640081002333	phosphorylation site [posttranslational modification]
640081002334	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
640081002335	ApbE family; Region: ApbE; pfam02424
640081002336	glutathione synthetase; Provisional; Region: PRK05246
640081002337	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
640081002338	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
640081002339	Glutamate-cysteine ligase; Region: GshA; pfam08886
640081002340	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
640081002341	NMT1/THI5 like; Region: NMT1; pfam09084
640081002342	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
640081002343	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081002344	dimerization interface [polypeptide binding]; other site
640081002345	PAS fold; Region: PAS_4; pfam08448
640081002346	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081002347	putative active site [active]
640081002348	heme pocket [chemical binding]; other site
640081002349	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081002350	PAS domain; Region: PAS_9; pfam13426
640081002351	putative active site [active]
640081002352	heme pocket [chemical binding]; other site
640081002353	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081002354	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081002355	metal binding site [ion binding]; metal-binding site
640081002356	active site
640081002357	I-site; other site
640081002358	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081002359	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
640081002360	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081002361	S-adenosylmethionine binding site [chemical binding]; other site
640081002362	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
640081002363	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081002364	Walker A/P-loop; other site
640081002365	ATP binding site [chemical binding]; other site
640081002366	Q-loop/lid; other site
640081002367	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
640081002368	ABC transporter; Region: ABC_tran_2; pfam12848
640081002369	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
640081002370	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
640081002371	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
640081002372	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081002373	Zn2+ binding site [ion binding]; other site
640081002374	Mg2+ binding site [ion binding]; other site
640081002375	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
640081002376	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
640081002377	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
640081002378	ABC transporter; Region: ABC_tran_2; pfam12848
640081002379	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
640081002380	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
640081002381	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
640081002382	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081002383	dimerization interface [polypeptide binding]; other site
640081002384	PAS domain; Region: PAS; smart00091
640081002385	PAS domain; Region: PAS_9; pfam13426
640081002386	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081002387	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081002388	metal binding site [ion binding]; metal-binding site
640081002389	active site
640081002390	I-site; other site
640081002391	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081002392	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
640081002393	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
640081002394	motif II; other site
640081002395	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
640081002396	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
640081002397	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
640081002398	putative active site [active]
640081002399	putative substrate binding site [chemical binding]; other site
640081002400	putative cosubstrate binding site; other site
640081002401	catalytic site [active]
640081002402	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
640081002403	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
640081002404	Nitrogen regulatory protein P-II; Region: P-II; smart00938
640081002405	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694
640081002406	Membrane fusogenic activity; Region: BMFP; pfam04380
640081002407	Staphylococcal nuclease homologues; Region: SNc; smart00318
640081002408	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
640081002409	Catalytic site; other site
640081002410	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
640081002411	multiple promoter invertase; Provisional; Region: mpi; PRK13413
640081002412	catalytic residues [active]
640081002413	catalytic nucleophile [active]
640081002414	Presynaptic Site I dimer interface [polypeptide binding]; other site
640081002415	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
640081002416	Synaptic Flat tetramer interface [polypeptide binding]; other site
640081002417	Synaptic Site I dimer interface [polypeptide binding]; other site
640081002418	DNA binding site [nucleotide binding]
640081002419	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
640081002420	DNA-binding interface [nucleotide binding]; DNA binding site
640081002421	Restriction endonuclease; Region: Mrr_cat; pfam04471
640081002422	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
640081002423	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
640081002424	catalytic residues [active]
640081002425	catalytic nucleophile [active]
640081002426	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
640081002427	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
640081002428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
640081002429	putative substrate translocation pore; other site
640081002430	Cache domain; Region: Cache_1; pfam02743
640081002431	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
640081002432	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081002433	putative active site [active]
640081002434	heme pocket [chemical binding]; other site
640081002435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081002436	dimer interface [polypeptide binding]; other site
640081002437	phosphorylation site [posttranslational modification]
640081002438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081002439	ATP binding site [chemical binding]; other site
640081002440	Mg2+ binding site [ion binding]; other site
640081002441	G-X-G motif; other site
640081002442	Response regulator receiver domain; Region: Response_reg; pfam00072
640081002443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081002444	active site
640081002445	phosphorylation site [posttranslational modification]
640081002446	intermolecular recognition site; other site
640081002447	dimerization interface [polypeptide binding]; other site
640081002448	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
640081002449	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081002450	active site
640081002451	phosphorylation site [posttranslational modification]
640081002452	intermolecular recognition site; other site
640081002453	dimerization interface [polypeptide binding]; other site
640081002454	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
640081002455	putative binding surface; other site
640081002456	active site
640081002457	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
640081002458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081002459	active site
640081002460	phosphorylation site [posttranslational modification]
640081002461	intermolecular recognition site; other site
640081002462	dimerization interface [polypeptide binding]; other site
640081002463	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081002464	Zn2+ binding site [ion binding]; other site
640081002465	Mg2+ binding site [ion binding]; other site
640081002466	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
640081002467	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
640081002468	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
640081002469	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
640081002470	substrate binding pocket [chemical binding]; other site
640081002471	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
640081002472	B12 binding site [chemical binding]; other site
640081002473	cobalt ligand [ion binding]; other site
640081002474	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
640081002475	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
640081002476	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
640081002477	NAD(P) binding site [chemical binding]; other site
640081002478	homotetramer interface [polypeptide binding]; other site
640081002479	homodimer interface [polypeptide binding]; other site
640081002480	active site
640081002481	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
640081002482	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
640081002483	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
640081002484	FAD binding pocket [chemical binding]; other site
640081002485	FAD binding motif [chemical binding]; other site
640081002486	phosphate binding motif [ion binding]; other site
640081002487	beta-alpha-beta structure motif; other site
640081002488	NAD binding pocket [chemical binding]; other site
640081002489	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
640081002490	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
640081002491	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
640081002492	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
640081002493	Coenzyme A binding pocket [chemical binding]; other site
640081002494	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
640081002495	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
640081002496	putative heme binding site [chemical binding]; other site
640081002497	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
640081002498	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081002499	FeS/SAM binding site; other site
640081002500	Predicted membrane protein [Function unknown]; Region: COG4125
640081002501	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
640081002502	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
640081002503	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
640081002504	SnoaL-like domain; Region: SnoaL_3; pfam13474
640081002505	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081002506	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081002507	metal binding site [ion binding]; metal-binding site
640081002508	active site
640081002509	I-site; other site
640081002510	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
640081002511	FAD binding domain; Region: FAD_binding_4; pfam01565
640081002512	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
640081002513	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
640081002514	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
640081002515	active site
640081002516	metal binding site [ion binding]; metal-binding site
640081002517	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
640081002518	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
640081002519	PDZ domain; Region: PDZ_2; pfam13180
640081002520	protein binding site [polypeptide binding]; other site
640081002521	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
640081002522	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
640081002523	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
640081002524	active site clefts [active]
640081002525	zinc binding site [ion binding]; other site
640081002526	dimer interface [polypeptide binding]; other site
640081002527	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
640081002528	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
640081002529	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
640081002530	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
640081002531	fructokinase; Reviewed; Region: PRK09557
640081002532	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
640081002533	nucleotide binding site [chemical binding]; other site
640081002534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
640081002535	MOSC domain; Region: MOSC; pfam03473
640081002536	PAS fold; Region: PAS_4; pfam08448
640081002537	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081002538	putative active site [active]
640081002539	heme pocket [chemical binding]; other site
640081002540	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081002541	PAS domain; Region: PAS_9; pfam13426
640081002542	putative active site [active]
640081002543	heme pocket [chemical binding]; other site
640081002544	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081002545	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081002546	metal binding site [ion binding]; metal-binding site
640081002547	active site
640081002548	I-site; other site
640081002549	primosome assembly protein PriA; Validated; Region: PRK05580
640081002550	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
640081002551	ATP binding site [chemical binding]; other site
640081002552	putative Mg++ binding site [ion binding]; other site
640081002553	helicase superfamily c-terminal domain; Region: HELICc; smart00490
640081002554	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
640081002555	substrate binding site [chemical binding]; other site
640081002556	active site
640081002557	Cation transport protein; Region: TrkH; cl17365
640081002558	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
640081002559	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
640081002560	TrkA-N domain; Region: TrkA_N; pfam02254
640081002561	TrkA-C domain; Region: TrkA_C; pfam02080
640081002562	TrkA-N domain; Region: TrkA_N; pfam02254
640081002563	TrkA-C domain; Region: TrkA_C; pfam02080
640081002564	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
640081002565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081002566	active site
640081002567	phosphorylation site [posttranslational modification]
640081002568	intermolecular recognition site; other site
640081002569	dimerization interface [polypeptide binding]; other site
640081002570	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081002571	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
640081002572	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081002573	dimerization interface [polypeptide binding]; other site
640081002574	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081002575	dimer interface [polypeptide binding]; other site
640081002576	phosphorylation site [posttranslational modification]
640081002577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081002578	ATP binding site [chemical binding]; other site
640081002579	Mg2+ binding site [ion binding]; other site
640081002580	G-X-G motif; other site
640081002581	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
640081002582	16S rRNA methyltransferase B; Provisional; Region: PRK10901
640081002583	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081002584	S-adenosylmethionine binding site [chemical binding]; other site
640081002585	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
640081002586	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
640081002587	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
640081002588	active site
640081002589	Zn binding site [ion binding]; other site
640081002590	M48 family peptidase; Provisional; Region: PRK03001
640081002591	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
640081002592	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
640081002593	putative active site [active]
640081002594	substrate binding site [chemical binding]; other site
640081002595	putative cosubstrate binding site; other site
640081002596	catalytic site [active]
640081002597	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
640081002598	substrate binding site [chemical binding]; other site
640081002599	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
640081002600	active site
640081002601	catalytic residues [active]
640081002602	metal binding site [ion binding]; metal-binding site
640081002603	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
640081002604	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
640081002605	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
640081002606	DNA protecting protein DprA; Region: dprA; TIGR00732
640081002607	Protein of unknown function (DUF494); Region: DUF494; pfam04361
640081002608	DNA topoisomerase III; Validated; Region: PRK08173
640081002609	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
640081002610	active site
640081002611	putative interdomain interaction site [polypeptide binding]; other site
640081002612	putative metal-binding site [ion binding]; other site
640081002613	putative nucleotide binding site [chemical binding]; other site
640081002614	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
640081002615	domain I; other site
640081002616	DNA binding groove [nucleotide binding]
640081002617	phosphate binding site [ion binding]; other site
640081002618	domain II; other site
640081002619	domain III; other site
640081002620	nucleotide binding site [chemical binding]; other site
640081002621	catalytic site [active]
640081002622	domain IV; other site
640081002623	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
640081002624	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
640081002625	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
640081002626	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
640081002627	dimerization interface [polypeptide binding]; other site
640081002628	DPS ferroxidase diiron center [ion binding]; other site
640081002629	ion pore; other site
640081002630	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081002631	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081002632	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
640081002633	dimerization interface [polypeptide binding]; other site
640081002634	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
640081002635	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
640081002636	RNA binding surface [nucleotide binding]; other site
640081002637	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
640081002638	active site
640081002639	uracil binding [chemical binding]; other site
640081002640	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
640081002641	dimer interface [polypeptide binding]; other site
640081002642	catalytic triad [active]
640081002643	peroxidatic and resolving cysteines [active]
640081002644	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
640081002645	Protein of unknown function DUF262; Region: DUF262; pfam03235
640081002646	Uncharacterized conserved protein [Function unknown]; Region: COG1479
640081002647	Protein of unknown function DUF262; Region: DUF262; pfam03235
640081002648	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
640081002649	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
640081002650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081002651	ATP binding site [chemical binding]; other site
640081002652	Mg2+ binding site [ion binding]; other site
640081002653	G-X-G motif; other site
640081002654	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
640081002655	anchoring element; other site
640081002656	dimer interface [polypeptide binding]; other site
640081002657	ATP binding site [chemical binding]; other site
640081002658	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
640081002659	active site
640081002660	putative metal-binding site [ion binding]; other site
640081002661	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
640081002662	DNA polymerase III subunit beta; Validated; Region: PRK05643
640081002663	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
640081002664	putative DNA binding surface [nucleotide binding]; other site
640081002665	dimer interface [polypeptide binding]; other site
640081002666	beta-clamp/clamp loader binding surface; other site
640081002667	beta-clamp/translesion DNA polymerase binding surface; other site
640081002668	DnaA N-terminal domain; Region: DnaA_N; pfam11638
640081002669	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
640081002670	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081002671	Walker A motif; other site
640081002672	ATP binding site [chemical binding]; other site
640081002673	Walker B motif; other site
640081002674	arginine finger; other site
640081002675	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
640081002676	DnaA box-binding interface [nucleotide binding]; other site
640081002677	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
640081002678	Ribonuclease P; Region: Ribonuclease_P; cl00457
640081002679	Haemolytic domain; Region: Haemolytic; pfam01809
640081002680	membrane protein insertase; Provisional; Region: PRK01318
640081002681	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
640081002682	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
640081002683	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
640081002684	trmE is a tRNA modification GTPase; Region: trmE; cd04164
640081002685	G1 box; other site
640081002686	GTP/Mg2+ binding site [chemical binding]; other site
640081002687	Switch I region; other site
640081002688	G2 box; other site
640081002689	Switch II region; other site
640081002690	G3 box; other site
640081002691	G4 box; other site
640081002692	G5 box; other site
640081002693	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
640081002694	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
640081002695	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
640081002696	putative ligand binding site [chemical binding]; other site
640081002697	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
640081002698	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
640081002699	putative ligand binding site [chemical binding]; other site
640081002700	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
640081002701	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
640081002702	Walker A/P-loop; other site
640081002703	ATP binding site [chemical binding]; other site
640081002704	Q-loop/lid; other site
640081002705	ABC transporter signature motif; other site
640081002706	Walker B; other site
640081002707	D-loop; other site
640081002708	H-loop/switch region; other site
640081002709	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
640081002710	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
640081002711	TM-ABC transporter signature motif; other site
640081002712	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
640081002713	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
640081002714	Walker A/P-loop; other site
640081002715	ATP binding site [chemical binding]; other site
640081002716	Q-loop/lid; other site
640081002717	ABC transporter signature motif; other site
640081002718	Walker B; other site
640081002719	D-loop; other site
640081002720	H-loop/switch region; other site
640081002721	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
640081002722	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
640081002723	TM-ABC transporter signature motif; other site
640081002724	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
640081002725	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
640081002726	putative ligand binding site [chemical binding]; other site
640081002727	Response regulator receiver domain; Region: Response_reg; pfam00072
640081002728	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081002729	active site
640081002730	phosphorylation site [posttranslational modification]
640081002731	intermolecular recognition site; other site
640081002732	dimerization interface [polypeptide binding]; other site
640081002733	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
640081002734	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
640081002735	TPR motif; other site
640081002736	binding surface
640081002737	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
640081002738	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
640081002739	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
640081002740	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
640081002741	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081002742	S-adenosylmethionine binding site [chemical binding]; other site
640081002743	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
640081002744	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
640081002745	P-loop; other site
640081002746	Magnesium ion binding site [ion binding]; other site
640081002747	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
640081002748	ParB-like nuclease domain; Region: ParB; smart00470
640081002749	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
640081002750	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
640081002751	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
640081002752	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
640081002753	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
640081002754	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
640081002755	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
640081002756	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
640081002757	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
640081002758	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
640081002759	beta subunit interaction interface [polypeptide binding]; other site
640081002760	Walker A motif; other site
640081002761	ATP binding site [chemical binding]; other site
640081002762	Walker B motif; other site
640081002763	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
640081002764	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
640081002765	core domain interface [polypeptide binding]; other site
640081002766	delta subunit interface [polypeptide binding]; other site
640081002767	epsilon subunit interface [polypeptide binding]; other site
640081002768	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
640081002769	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
640081002770	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
640081002771	alpha subunit interaction interface [polypeptide binding]; other site
640081002772	Walker A motif; other site
640081002773	ATP binding site [chemical binding]; other site
640081002774	Walker B motif; other site
640081002775	inhibitor binding site; inhibition site
640081002776	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
640081002777	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
640081002778	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
640081002779	gamma subunit interface [polypeptide binding]; other site
640081002780	epsilon subunit interface [polypeptide binding]; other site
640081002781	LBP interface [polypeptide binding]; other site
640081002782	SCP-2 sterol transfer family; Region: SCP2; pfam02036
640081002783	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
640081002784	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
640081002785	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081002786	S-adenosylmethionine binding site [chemical binding]; other site
640081002787	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
640081002788	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
640081002789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081002790	active site
640081002791	phosphorylation site [posttranslational modification]
640081002792	intermolecular recognition site; other site
640081002793	dimerization interface [polypeptide binding]; other site
640081002794	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081002795	DNA binding site [nucleotide binding]
640081002796	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
640081002797	PAS domain; Region: PAS; smart00091
640081002798	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081002799	dimer interface [polypeptide binding]; other site
640081002800	phosphorylation site [posttranslational modification]
640081002801	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081002802	ATP binding site [chemical binding]; other site
640081002803	Mg2+ binding site [ion binding]; other site
640081002804	G-X-G motif; other site
640081002805	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
640081002806	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
640081002807	YqjK-like protein; Region: YqjK; pfam13997
640081002808	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
640081002809	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
640081002810	putative active site [active]
640081002811	putative catalytic site [active]
640081002812	putative DNA binding site [nucleotide binding]; other site
640081002813	putative phosphate binding site [ion binding]; other site
640081002814	metal binding site A [ion binding]; metal-binding site
640081002815	putative AP binding site [nucleotide binding]; other site
640081002816	putative metal binding site B [ion binding]; other site
640081002817	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
640081002818	active site
640081002819	AzlC protein; Region: AzlC; pfam03591
640081002820	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
640081002821	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
640081002822	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
640081002823	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
640081002824	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
640081002825	Subunit I/III interface [polypeptide binding]; other site
640081002826	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
640081002827	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081002828	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081002829	ligand binding site [chemical binding]; other site
640081002830	flexible hinge region; other site
640081002831	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
640081002832	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
640081002833	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
640081002834	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
640081002835	DNA-binding site [nucleotide binding]; DNA binding site
640081002836	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081002837	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081002838	homodimer interface [polypeptide binding]; other site
640081002839	catalytic residue [active]
640081002840	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
640081002841	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
640081002842	GatB domain; Region: GatB_Yqey; smart00845
640081002843	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
640081002844	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
640081002845	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
640081002846	rod shape-determining protein MreB; Provisional; Region: PRK13927
640081002847	MreB and similar proteins; Region: MreB_like; cd10225
640081002848	nucleotide binding site [chemical binding]; other site
640081002849	Mg binding site [ion binding]; other site
640081002850	putative protofilament interaction site [polypeptide binding]; other site
640081002851	RodZ interaction site [polypeptide binding]; other site
640081002852	rod shape-determining protein MreC; Provisional; Region: PRK13922
640081002853	rod shape-determining protein MreC; Region: MreC; pfam04085
640081002854	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
640081002855	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
640081002856	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
640081002857	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
640081002858	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
640081002859	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
640081002860	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
640081002861	Sporulation related domain; Region: SPOR; pfam05036
640081002862	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
640081002863	GAF domain; Region: GAF; pfam01590
640081002864	PAS fold; Region: PAS_4; pfam08448
640081002865	PAS domain; Region: PAS_9; pfam13426
640081002866	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081002867	putative active site [active]
640081002868	heme pocket [chemical binding]; other site
640081002869	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081002870	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081002871	metal binding site [ion binding]; metal-binding site
640081002872	active site
640081002873	I-site; other site
640081002874	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081002875	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
640081002876	Nitrogen regulatory protein P-II; Region: P-II; smart00938
640081002877	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
640081002878	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
640081002879	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081002880	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
640081002881	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
640081002882	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
640081002883	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
640081002884	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
640081002885	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
640081002886	homodimer interface [polypeptide binding]; other site
640081002887	substrate-cofactor binding pocket; other site
640081002888	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081002889	catalytic residue [active]
640081002890	Protein of unknown function (DUF493); Region: DUF493; cl01102
640081002891	lipoate-protein ligase B; Provisional; Region: PRK14342
640081002892	lipoyl synthase; Provisional; Region: PRK05481
640081002893	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081002894	FeS/SAM binding site; other site
640081002895	KTSC domain; Region: KTSC; pfam13619
640081002896	Domain of unknown function DUF87; Region: DUF87; pfam01935
640081002897	AAA-like domain; Region: AAA_10; pfam12846
640081002898	SIR2-like domain; Region: SIR2_2; pfam13289
640081002899	Caspase domain; Region: Peptidase_C14; pfam00656
640081002900	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
640081002901	TniQ; Region: TniQ; pfam06527
640081002902	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081002903	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
640081002904	Walker A motif; other site
640081002905	ATP binding site [chemical binding]; other site
640081002906	Walker B motif; other site
640081002907	arginine finger; other site
640081002908	Integrase core domain; Region: rve; pfam00665
640081002909	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
640081002910	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
640081002911	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
640081002912	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081002913	active site
640081002914	phosphorylation site [posttranslational modification]
640081002915	intermolecular recognition site; other site
640081002916	dimerization interface [polypeptide binding]; other site
640081002917	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081002918	Zn2+ binding site [ion binding]; other site
640081002919	Mg2+ binding site [ion binding]; other site
640081002920	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
640081002921	catalytic core [active]
640081002922	PAS fold; Region: PAS_4; pfam08448
640081002923	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081002924	putative active site [active]
640081002925	heme pocket [chemical binding]; other site
640081002926	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081002927	PAS fold; Region: PAS_3; pfam08447
640081002928	putative active site [active]
640081002929	heme pocket [chemical binding]; other site
640081002930	PAS domain S-box; Region: sensory_box; TIGR00229
640081002931	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081002932	putative active site [active]
640081002933	heme pocket [chemical binding]; other site
640081002934	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081002935	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081002936	dimer interface [polypeptide binding]; other site
640081002937	phosphorylation site [posttranslational modification]
640081002938	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081002939	ATP binding site [chemical binding]; other site
640081002940	Mg2+ binding site [ion binding]; other site
640081002941	G-X-G motif; other site
640081002942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081002943	Response regulator receiver domain; Region: Response_reg; pfam00072
640081002944	active site
640081002945	phosphorylation site [posttranslational modification]
640081002946	intermolecular recognition site; other site
640081002947	dimerization interface [polypeptide binding]; other site
640081002948	Response regulator receiver domain; Region: Response_reg; pfam00072
640081002949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081002950	active site
640081002951	phosphorylation site [posttranslational modification]
640081002952	intermolecular recognition site; other site
640081002953	dimerization interface [polypeptide binding]; other site
640081002954	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
640081002955	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081002956	N-terminal plug; other site
640081002957	ligand-binding site [chemical binding]; other site
640081002958	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
640081002959	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
640081002960	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
640081002961	Predicted permease; Region: DUF318; cl17795
640081002962	Predicted permease; Region: DUF318; cl17795
640081002963	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
640081002964	fumarate hydratase; Reviewed; Region: fumC; PRK00485
640081002965	Class II fumarases; Region: Fumarase_classII; cd01362
640081002966	active site
640081002967	tetramer interface [polypeptide binding]; other site
640081002968	Cytochrome c; Region: Cytochrom_C; cl11414
640081002969	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
640081002970	4Fe-4S binding domain; Region: Fer4_5; pfam12801
640081002971	4Fe-4S binding domain; Region: Fer4; pfam00037
640081002972	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
640081002973	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
640081002974	PAS fold; Region: PAS_4; pfam08448
640081002975	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
640081002976	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081002977	Walker B motif; other site
640081002978	arginine finger; other site
640081002979	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
640081002980	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
640081002981	catalytic residues [active]
640081002982	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
640081002983	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
640081002984	Part of AAA domain; Region: AAA_19; pfam13245
640081002985	Family description; Region: UvrD_C_2; pfam13538
640081002986	Cytochrome c; Region: Cytochrom_C; cl11414
640081002987	PAS domain; Region: PAS_9; pfam13426
640081002988	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
640081002989	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081002990	Zn2+ binding site [ion binding]; other site
640081002991	Mg2+ binding site [ion binding]; other site
640081002992	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081002993	dimerization interface [polypeptide binding]; other site
640081002994	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081002995	metal binding site [ion binding]; metal-binding site
640081002996	active site
640081002997	I-site; other site
640081002998	Nif-specific regulatory protein; Region: nifA; TIGR01817
640081002999	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
640081003000	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081003001	Walker A motif; other site
640081003002	ATP binding site [chemical binding]; other site
640081003003	Walker B motif; other site
640081003004	arginine finger; other site
640081003005	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081003006	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
640081003007	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
640081003008	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081003009	FeS/SAM binding site; other site
640081003010	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
640081003011	Ferredoxin [Energy production and conversion]; Region: COG1146
640081003012	4Fe-4S binding domain; Region: Fer4; cl02805
640081003013	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
640081003014	NifZ domain; Region: NifZ; pfam04319
640081003015	NifT/FixU protein; Region: NifT; pfam06988
640081003016	SIR2-like domain; Region: SIR2_2; pfam13289
640081003017	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
640081003018	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
640081003019	putative active site [active]
640081003020	putative catalytic site [active]
640081003021	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
640081003022	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
640081003023	NAD(P) binding site [chemical binding]; other site
640081003024	active site
640081003025	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
640081003026	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
640081003027	Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357
640081003028	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
640081003029	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
640081003030	Nucleotide-binding sites [chemical binding]; other site
640081003031	Walker A motif; other site
640081003032	Switch I region of nucleotide binding site; other site
640081003033	Fe4S4 binding sites [ion binding]; other site
640081003034	Switch II region of nucleotide binding site; other site
640081003035	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
640081003036	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
640081003037	MoFe protein alpha/beta subunit interactions; other site
640081003038	Alpha subunit P cluster binding residues; other site
640081003039	FeMoco binding residues [chemical binding]; other site
640081003040	MoFe protein alpha subunit/Fe protein contacts; other site
640081003041	MoFe protein dimer/ dimer interactions; other site
640081003042	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
640081003043	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
640081003044	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
640081003045	MoFe protein beta/alpha subunit interactions; other site
640081003046	Beta subunit P cluster binding residues; other site
640081003047	MoFe protein beta subunit/Fe protein contacts; other site
640081003048	MoFe protein dimer/ dimer interactions; other site
640081003049	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
640081003050	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
640081003051	catalytic loop [active]
640081003052	iron binding site [ion binding]; other site
640081003053	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
640081003054	Predicted permeases [General function prediction only]; Region: COG0701
640081003055	RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959
640081003056	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081003057	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
640081003058	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
640081003059	Peptidase family U32; Region: Peptidase_U32; pfam01136
640081003060	putative protease; Provisional; Region: PRK15447
640081003061	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
640081003062	SCP-2 sterol transfer family; Region: SCP2; cl01225
640081003063	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
640081003064	MgtC family; Region: MgtC; pfam02308
640081003065	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081003066	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081003067	dimerization interface [polypeptide binding]; other site
640081003068	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081003069	dimer interface [polypeptide binding]; other site
640081003070	putative CheW interface [polypeptide binding]; other site
640081003071	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
640081003072	Active_site [active]
640081003073	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
640081003074	PAS domain S-box; Region: sensory_box; TIGR00229
640081003075	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081003076	putative active site [active]
640081003077	heme pocket [chemical binding]; other site
640081003078	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081003079	PAS fold; Region: PAS_3; pfam08447
640081003080	putative active site [active]
640081003081	heme pocket [chemical binding]; other site
640081003082	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081003083	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081003084	metal binding site [ion binding]; metal-binding site
640081003085	active site
640081003086	I-site; other site
640081003087	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
640081003088	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
640081003089	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
640081003090	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
640081003091	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
640081003092	DNA binding residues [nucleotide binding]
640081003093	putative dimer interface [polypeptide binding]; other site
640081003094	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
640081003095	CoenzymeA binding site [chemical binding]; other site
640081003096	subunit interaction site [polypeptide binding]; other site
640081003097	PHB binding site; other site
640081003098	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
640081003099	isovaleryl-CoA dehydrogenase; Region: PLN02519
640081003100	substrate binding site [chemical binding]; other site
640081003101	FAD binding site [chemical binding]; other site
640081003102	catalytic base [active]
640081003103	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
640081003104	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
640081003105	dimer interface [polypeptide binding]; other site
640081003106	active site
640081003107	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
640081003108	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
640081003109	active site
640081003110	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
640081003111	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
640081003112	putative catalytic residue [active]
640081003113	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
640081003114	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
640081003115	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
640081003116	enoyl-CoA hydratase; Provisional; Region: PRK05995
640081003117	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
640081003118	substrate binding site [chemical binding]; other site
640081003119	oxyanion hole (OAH) forming residues; other site
640081003120	trimer interface [polypeptide binding]; other site
640081003121	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
640081003122	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
640081003123	ATP-grasp domain; Region: ATP-grasp_4; cl17255
640081003124	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
640081003125	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
640081003126	carboxyltransferase (CT) interaction site; other site
640081003127	biotinylation site [posttranslational modification]; other site
640081003128	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
640081003129	PAS domain; Region: PAS_9; pfam13426
640081003130	putative active site [active]
640081003131	heme pocket [chemical binding]; other site
640081003132	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081003133	metal binding site [ion binding]; metal-binding site
640081003134	active site
640081003135	I-site; other site
640081003136	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081003137	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
640081003138	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
640081003139	active site
640081003140	catalytic residues [active]
640081003141	metal binding site [ion binding]; metal-binding site
640081003142	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
640081003143	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
640081003144	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
640081003145	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
640081003146	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
640081003147	metal binding site [ion binding]; metal-binding site
640081003148	putative dimer interface [polypeptide binding]; other site
640081003149	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
640081003150	NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910
640081003151	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
640081003152	aromatic acid decarboxylase; Validated; Region: PRK05920
640081003153	Flavoprotein; Region: Flavoprotein; pfam02441
640081003154	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
640081003155	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
640081003156	Major Facilitator Superfamily; Region: MFS_1; pfam07690
640081003157	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
640081003158	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
640081003159	N-acetyl-D-glucosamine binding site [chemical binding]; other site
640081003160	catalytic residue [active]
640081003161	Cache domain; Region: Cache_1; pfam02743
640081003162	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081003163	dimer interface [polypeptide binding]; other site
640081003164	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
640081003165	putative CheW interface [polypeptide binding]; other site
640081003166	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
640081003167	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
640081003168	minor groove reading motif; other site
640081003169	helix-hairpin-helix signature motif; other site
640081003170	substrate binding pocket [chemical binding]; other site
640081003171	active site
640081003172	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
640081003173	DNA binding and oxoG recognition site [nucleotide binding]
640081003174	MoxR-like ATPases [General function prediction only]; Region: COG0714
640081003175	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081003176	Walker A motif; other site
640081003177	ATP binding site [chemical binding]; other site
640081003178	Walker B motif; other site
640081003179	arginine finger; other site
640081003180	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
640081003181	Protein of unknown function DUF58; Region: DUF58; pfam01882
640081003182	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
640081003183	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
640081003184	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
640081003185	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
640081003186	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
640081003187	ATP-grasp domain; Region: ATP-grasp; pfam02222
640081003188	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
640081003189	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081003190	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081003191	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
640081003192	putative effector binding pocket; other site
640081003193	dimerization interface [polypeptide binding]; other site
640081003194	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
640081003195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
640081003196	putative substrate translocation pore; other site
640081003197	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
640081003198	PAS domain S-box; Region: sensory_box; TIGR00229
640081003199	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081003200	putative active site [active]
640081003201	heme pocket [chemical binding]; other site
640081003202	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081003203	PAS domain; Region: PAS_9; pfam13426
640081003204	putative active site [active]
640081003205	heme pocket [chemical binding]; other site
640081003206	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081003207	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081003208	dimer interface [polypeptide binding]; other site
640081003209	phosphorylation site [posttranslational modification]
640081003210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081003211	ATP binding site [chemical binding]; other site
640081003212	Mg2+ binding site [ion binding]; other site
640081003213	G-X-G motif; other site
640081003214	Response regulator receiver domain; Region: Response_reg; pfam00072
640081003215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081003216	active site
640081003217	phosphorylation site [posttranslational modification]
640081003218	intermolecular recognition site; other site
640081003219	dimerization interface [polypeptide binding]; other site
640081003220	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
640081003221	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
640081003222	ligand binding site [chemical binding]; other site
640081003223	CHASE domain; Region: CHASE; cl01369
640081003224	PAS domain S-box; Region: sensory_box; TIGR00229
640081003225	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081003226	putative active site [active]
640081003227	heme pocket [chemical binding]; other site
640081003228	PAS fold; Region: PAS_4; pfam08448
640081003229	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081003230	PAS domain; Region: PAS_9; pfam13426
640081003231	putative active site [active]
640081003232	heme pocket [chemical binding]; other site
640081003233	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081003234	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081003235	metal binding site [ion binding]; metal-binding site
640081003236	active site
640081003237	I-site; other site
640081003238	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081003239	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
640081003240	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
640081003241	putative ligand binding site [chemical binding]; other site
640081003242	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
640081003243	thiS-thiF/thiG interaction site; other site
640081003244	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
640081003245	ThiS interaction site; other site
640081003246	putative active site [active]
640081003247	tetramer interface [polypeptide binding]; other site
640081003248	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
640081003249	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
640081003250	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
640081003251	Transposase; Region: DEDD_Tnp_IS110; pfam01548
640081003252	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
640081003253	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
640081003254	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
640081003255	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
640081003256	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
640081003257	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
640081003258	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081003259	Walker A/P-loop; other site
640081003260	ATP binding site [chemical binding]; other site
640081003261	Q-loop/lid; other site
640081003262	ABC transporter signature motif; other site
640081003263	Walker B; other site
640081003264	D-loop; other site
640081003265	H-loop/switch region; other site
640081003266	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
640081003267	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
640081003268	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
640081003269	P loop; other site
640081003270	GTP binding site [chemical binding]; other site
640081003271	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
640081003272	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
640081003273	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
640081003274	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
640081003275	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
640081003276	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
640081003277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081003278	S-adenosylmethionine binding site [chemical binding]; other site
640081003279	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
640081003280	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
640081003281	active site
640081003282	(T/H)XGH motif; other site
640081003283	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
640081003284	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
640081003285	Dynamin family; Region: Dynamin_N; pfam00350
640081003286	G1 box; other site
640081003287	GTP/Mg2+ binding site [chemical binding]; other site
640081003288	G2 box; other site
640081003289	Switch I region; other site
640081003290	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
640081003291	G3 box; other site
640081003292	Switch II region; other site
640081003293	GTP/Mg2+ binding site [chemical binding]; other site
640081003294	G4 box; other site
640081003295	G5 box; other site
640081003296	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
640081003297	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
640081003298	DNA binding site [nucleotide binding]
640081003299	catalytic residue [active]
640081003300	H2TH interface [polypeptide binding]; other site
640081003301	putative catalytic residues [active]
640081003302	turnover-facilitating residue; other site
640081003303	intercalation triad [nucleotide binding]; other site
640081003304	8OG recognition residue [nucleotide binding]; other site
640081003305	putative reading head residues; other site
640081003306	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
640081003307	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
640081003308	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081003309	TPR motif; other site
640081003310	binding surface
640081003311	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081003312	TPR motif; other site
640081003313	binding surface
640081003314	Tetratricopeptide repeat; Region: TPR_16; pfam13432
640081003315	TPR repeat; Region: TPR_11; pfam13414
640081003316	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
640081003317	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
640081003318	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
640081003319	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
640081003320	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
640081003321	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
640081003322	active site
640081003323	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
640081003324	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
640081003325	5S rRNA interface [nucleotide binding]; other site
640081003326	CTC domain interface [polypeptide binding]; other site
640081003327	L16 interface [polypeptide binding]; other site
640081003328	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
640081003329	putative active site [active]
640081003330	catalytic residue [active]
640081003331	GTP-binding protein YchF; Reviewed; Region: PRK09601
640081003332	YchF GTPase; Region: YchF; cd01900
640081003333	G1 box; other site
640081003334	GTP/Mg2+ binding site [chemical binding]; other site
640081003335	Switch I region; other site
640081003336	G2 box; other site
640081003337	Switch II region; other site
640081003338	G3 box; other site
640081003339	G4 box; other site
640081003340	G5 box; other site
640081003341	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
640081003342	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
640081003343	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
640081003344	active site
640081003345	HIGH motif; other site
640081003346	nucleotide binding site [chemical binding]; other site
640081003347	active site
640081003348	KMSKS motif; other site
640081003349	cardiolipin synthase 2; Provisional; Region: PRK11263
640081003350	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
640081003351	putative active site [active]
640081003352	catalytic site [active]
640081003353	SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755
640081003354	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
640081003355	putative active site [active]
640081003356	catalytic site [active]
640081003357	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
640081003358	putative catalytic site [active]
640081003359	putative metal binding site [ion binding]; other site
640081003360	putative phosphate binding site [ion binding]; other site
640081003361	quinolinate synthetase; Provisional; Region: PRK09375
640081003362	CHAT domain; Region: CHAT; pfam12770
640081003363	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
640081003364	active site residue [active]
640081003365	glutamine synthetase; Provisional; Region: glnA; PRK09469
640081003366	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
640081003367	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
640081003368	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
640081003369	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
640081003370	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
640081003371	putative active site [active]
640081003372	heme pocket [chemical binding]; other site
640081003373	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081003374	dimer interface [polypeptide binding]; other site
640081003375	phosphorylation site [posttranslational modification]
640081003376	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081003377	ATP binding site [chemical binding]; other site
640081003378	Mg2+ binding site [ion binding]; other site
640081003379	G-X-G motif; other site
640081003380	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
640081003381	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081003382	active site
640081003383	phosphorylation site [posttranslational modification]
640081003384	intermolecular recognition site; other site
640081003385	dimerization interface [polypeptide binding]; other site
640081003386	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081003387	Walker A motif; other site
640081003388	ATP binding site [chemical binding]; other site
640081003389	Walker B motif; other site
640081003390	arginine finger; other site
640081003391	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081003392	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
640081003393	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
640081003394	Type III pantothenate kinase; Region: Pan_kinase; cl17198
640081003395	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
640081003396	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
640081003397	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
640081003398	catalytic residue [active]
640081003399	Sporulation related domain; Region: SPOR; pfam05036
640081003400	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
640081003401	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
640081003402	CoA-binding site [chemical binding]; other site
640081003403	ATP-binding [chemical binding]; other site
640081003404	hypothetical protein; Provisional; Region: PRK05287
640081003405	Domain of unknown function (DUF329); Region: DUF329; pfam03884
640081003406	hypothetical protein; Provisional; Region: PRK08999
640081003407	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
640081003408	active site
640081003409	8-oxo-dGMP binding site [chemical binding]; other site
640081003410	nudix motif; other site
640081003411	metal binding site [ion binding]; metal-binding site
640081003412	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
640081003413	active site
640081003414	thiamine phosphate binding site [chemical binding]; other site
640081003415	pyrophosphate binding site [ion binding]; other site
640081003416	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
640081003417	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081003418	Walker A motif; other site
640081003419	ATP binding site [chemical binding]; other site
640081003420	Walker B motif; other site
640081003421	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
640081003422	MltA specific insert domain; Region: MltA; smart00925
640081003423	3D domain; Region: 3D; pfam06725
640081003424	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
640081003425	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
640081003426	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
640081003427	DNA binding residues [nucleotide binding]
640081003428	dimer interface [polypeptide binding]; other site
640081003429	copper binding site [ion binding]; other site
640081003430	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
640081003431	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
640081003432	metal-binding site [ion binding]
640081003433	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
640081003434	Soluble P-type ATPase [General function prediction only]; Region: COG4087
640081003435	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
640081003436	metal-binding site [ion binding]
640081003437	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
640081003438	HAMP domain; Region: HAMP; pfam00672
640081003439	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081003440	dimer interface [polypeptide binding]; other site
640081003441	phosphorylation site [posttranslational modification]
640081003442	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081003443	ATP binding site [chemical binding]; other site
640081003444	Mg2+ binding site [ion binding]; other site
640081003445	G-X-G motif; other site
640081003446	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
640081003447	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081003448	active site
640081003449	phosphorylation site [posttranslational modification]
640081003450	intermolecular recognition site; other site
640081003451	dimerization interface [polypeptide binding]; other site
640081003452	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081003453	DNA binding site [nucleotide binding]
640081003454	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
640081003455	Predicted metal-binding protein [General function prediction only]; Region: COG3019
640081003456	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
640081003457	Outer membrane efflux protein; Region: OEP; pfam02321
640081003458	Outer membrane efflux protein; Region: OEP; pfam02321
640081003459	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
640081003460	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081003461	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
640081003462	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
640081003463	YHS domain; Region: YHS; pfam04945
640081003464	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
640081003465	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
640081003466	Soluble P-type ATPase [General function prediction only]; Region: COG4087
640081003467	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
640081003468	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
640081003469	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
640081003470	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
640081003471	Copper resistance protein K; Region: CopK; pfam11525
640081003472	Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505
640081003473	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
640081003474	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
640081003475	AAA domain; Region: AAA_22; pfam13401
640081003476	TniQ; Region: TniQ; pfam06527
640081003477	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081003478	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081003479	dimer interface [polypeptide binding]; other site
640081003480	putative CheW interface [polypeptide binding]; other site
640081003481	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
640081003482	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
640081003483	dimerization domain [polypeptide binding]; other site
640081003484	dimer interface [polypeptide binding]; other site
640081003485	catalytic residues [active]
640081003486	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608
640081003487	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
640081003488	shikimate kinase; Reviewed; Region: aroK; PRK00131
640081003489	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
640081003490	ADP binding site [chemical binding]; other site
640081003491	magnesium binding site [ion binding]; other site
640081003492	putative shikimate binding site; other site
640081003493	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
640081003494	active site
640081003495	dimer interface [polypeptide binding]; other site
640081003496	metal binding site [ion binding]; metal-binding site
640081003497	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
640081003498	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
640081003499	active site
640081003500	dimer interface [polypeptide binding]; other site
640081003501	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
640081003502	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
640081003503	active site
640081003504	FMN binding site [chemical binding]; other site
640081003505	substrate binding site [chemical binding]; other site
640081003506	3Fe-4S cluster binding site [ion binding]; other site
640081003507	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
640081003508	domain interface; other site
640081003509	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
640081003510	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
640081003511	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
640081003512	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
640081003513	Substrate binding site; other site
640081003514	Mg++ binding site; other site
640081003515	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
640081003516	active site
640081003517	substrate binding site [chemical binding]; other site
640081003518	CoA binding site [chemical binding]; other site
640081003519	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
640081003520	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
640081003521	glutaminase active site [active]
640081003522	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
640081003523	dimer interface [polypeptide binding]; other site
640081003524	active site
640081003525	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
640081003526	dimer interface [polypeptide binding]; other site
640081003527	active site
640081003528	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
640081003529	Helix-turn-helix domain; Region: HTH_18; pfam12833
640081003530	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
640081003531	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
640081003532	CoenzymeA binding site [chemical binding]; other site
640081003533	subunit interaction site [polypeptide binding]; other site
640081003534	PHB binding site; other site
640081003535	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
640081003536	B12 binding site [chemical binding]; other site
640081003537	cobalt ligand [ion binding]; other site
640081003538	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
640081003539	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678
640081003540	putative active site [active]
640081003541	putative substrate binding site [chemical binding]; other site
640081003542	putative coenzyme B12 binding site [chemical binding]; other site
640081003543	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
640081003544	putative FMN binding site [chemical binding]; other site
640081003545	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081003546	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081003547	ligand binding site [chemical binding]; other site
640081003548	flexible hinge region; other site
640081003549	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
640081003550	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
640081003551	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
640081003552	acyl-activating enzyme (AAE) consensus motif; other site
640081003553	putative AMP binding site [chemical binding]; other site
640081003554	putative active site [active]
640081003555	putative CoA binding site [chemical binding]; other site
640081003556	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
640081003557	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
640081003558	Walker A/P-loop; other site
640081003559	ATP binding site [chemical binding]; other site
640081003560	Q-loop/lid; other site
640081003561	ABC transporter signature motif; other site
640081003562	Walker B; other site
640081003563	D-loop; other site
640081003564	H-loop/switch region; other site
640081003565	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
640081003566	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
640081003567	TM-ABC transporter signature motif; other site
640081003568	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
640081003569	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
640081003570	TM-ABC transporter signature motif; other site
640081003571	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
640081003572	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
640081003573	putative ligand binding site [chemical binding]; other site
640081003574	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
640081003575	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
640081003576	Walker A/P-loop; other site
640081003577	ATP binding site [chemical binding]; other site
640081003578	Q-loop/lid; other site
640081003579	ABC transporter signature motif; other site
640081003580	Walker B; other site
640081003581	D-loop; other site
640081003582	H-loop/switch region; other site
640081003583	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
640081003584	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
640081003585	acyl-activating enzyme (AAE) consensus motif; other site
640081003586	active site
640081003587	AMP binding site [chemical binding]; other site
640081003588	CoA binding site [chemical binding]; other site
640081003589	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
640081003590	CoA-transferase family III; Region: CoA_transf_3; pfam02515
640081003591	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
640081003592	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081003593	HAMP domain; Region: HAMP; pfam00672
640081003594	dimerization interface [polypeptide binding]; other site
640081003595	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081003596	dimer interface [polypeptide binding]; other site
640081003597	putative CheW interface [polypeptide binding]; other site
640081003598	Hemerythrin; Region: Hemerythrin; cd12107
640081003599	Fe binding site [ion binding]; other site
640081003600	Predicted permeases [General function prediction only]; Region: COG0679
640081003601	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
640081003602	catalytic residues [active]
640081003603	dimer interface [polypeptide binding]; other site
640081003604	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
640081003605	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
640081003606	Cu(I) binding site [ion binding]; other site
640081003607	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
640081003608	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081003609	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081003610	DNA binding residues [nucleotide binding]
640081003611	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
640081003612	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
640081003613	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
640081003614	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081003615	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
640081003616	dimer interface [polypeptide binding]; other site
640081003617	putative CheW interface [polypeptide binding]; other site
640081003618	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
640081003619	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
640081003620	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081003621	N-terminal plug; other site
640081003622	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
640081003623	ligand-binding site [chemical binding]; other site
640081003624	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
640081003625	Rci recombinase, C-terminal catalytic domain.  Rci enzymes are found in IncI1 incompatibility group plasmids such as R64.  These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796
640081003626	catalytic residues [active]
640081003627	Int/Topo IB signature motif; other site
640081003628	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
640081003629	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
640081003630	carboxyltransferase (CT) interaction site; other site
640081003631	biotinylation site [posttranslational modification]; other site
640081003632	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081003633	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
640081003634	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
640081003635	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
640081003636	H+ Antiporter protein; Region: 2A0121; TIGR00900
640081003637	putative substrate translocation pore; other site
640081003638	flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
640081003639	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
640081003640	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
640081003641	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
640081003642	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
640081003643	Chromate transporter; Region: Chromate_transp; pfam02417
640081003644	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
640081003645	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
640081003646	active site
640081003647	catalytic residues [active]
640081003648	DNA binding site [nucleotide binding]
640081003649	Int/Topo IB signature motif; other site
640081003650	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
640081003651	DNA binding site [nucleotide binding]
640081003652	active site
640081003653	Int/Topo IB signature motif; other site
640081003654	catalytic residues [active]
640081003655	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
640081003656	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
640081003657	active site
640081003658	DNA binding site [nucleotide binding]
640081003659	Int/Topo IB signature motif; other site
640081003660	High-affinity nickel-transport protein; Region: NicO; cl00964
640081003661	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
640081003662	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081003663	putative active site [active]
640081003664	heme pocket [chemical binding]; other site
640081003665	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081003666	dimer interface [polypeptide binding]; other site
640081003667	phosphorylation site [posttranslational modification]
640081003668	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081003669	ATP binding site [chemical binding]; other site
640081003670	G-X-G motif; other site
640081003671	nickel responsive regulator; Provisional; Region: PRK02967
640081003672	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
640081003673	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
640081003674	heat shock protein HtpX; Provisional; Region: PRK05457
640081003675	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
640081003676	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081003677	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
640081003678	putative dimerization interface [polypeptide binding]; other site
640081003679	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
640081003680	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
640081003681	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
640081003682	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
640081003683	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
640081003684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081003685	active site
640081003686	phosphorylation site [posttranslational modification]
640081003687	intermolecular recognition site; other site
640081003688	dimerization interface [polypeptide binding]; other site
640081003689	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081003690	Walker A motif; other site
640081003691	ATP binding site [chemical binding]; other site
640081003692	Walker B motif; other site
640081003693	arginine finger; other site
640081003694	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081003695	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
640081003696	putative active site [active]
640081003697	putative substrate binding site [chemical binding]; other site
640081003698	putative cosubstrate binding site; other site
640081003699	catalytic site [active]
640081003700	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
640081003701	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
640081003702	substrate binding site [chemical binding]; other site
640081003703	oxyanion hole (OAH) forming residues; other site
640081003704	trimer interface [polypeptide binding]; other site
640081003705	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
640081003706	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
640081003707	dimerization interface [polypeptide binding]; other site
640081003708	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
640081003709	ATP binding site [chemical binding]; other site
640081003710	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
640081003711	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
640081003712	HupF/HypC family; Region: HupF_HypC; pfam01455
640081003713	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
640081003714	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
640081003715	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
640081003716	Acylphosphatase; Region: Acylphosphatase; pfam00708
640081003717	HypF finger; Region: zf-HYPF; pfam07503
640081003718	HypF finger; Region: zf-HYPF; pfam07503
640081003719	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
640081003720	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
640081003721	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
640081003722	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
640081003723	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
640081003724	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
640081003725	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
640081003726	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081003727	Walker A/P-loop; other site
640081003728	ATP binding site [chemical binding]; other site
640081003729	Q-loop/lid; other site
640081003730	ABC transporter signature motif; other site
640081003731	Walker B; other site
640081003732	D-loop; other site
640081003733	H-loop/switch region; other site
640081003734	CcmB protein; Region: CcmB; pfam03379
640081003735	heme exporter protein CcmC; Region: ccmC; TIGR01191
640081003736	Heme exporter protein D (CcmD); Region: CcmD; cl11475
640081003737	CcmE; Region: CcmE; pfam03100
640081003738	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
640081003739	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
640081003740	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
640081003741	catalytic residues [active]
640081003742	central insert; other site
640081003743	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
640081003744	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
640081003745	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081003746	binding surface
640081003747	TPR motif; other site
640081003748	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
640081003749	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
640081003750	Ethylbenzene dehydrogenase; Region: EB_dh; smart00887
640081003751	putative ligand binding site [chemical binding]; other site
640081003752	ferredoxin-type protein; Provisional; Region: PRK10194
640081003753	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
640081003754	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
640081003755	RNA binding surface [nucleotide binding]; other site
640081003756	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
640081003757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081003758	active site
640081003759	phosphorylation site [posttranslational modification]
640081003760	intermolecular recognition site; other site
640081003761	dimerization interface [polypeptide binding]; other site
640081003762	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081003763	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081003764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081003765	ATP binding site [chemical binding]; other site
640081003766	Mg2+ binding site [ion binding]; other site
640081003767	G-X-G motif; other site
640081003768	diaminopimelate decarboxylase; Region: lysA; TIGR01048
640081003769	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
640081003770	active site
640081003771	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
640081003772	substrate binding site [chemical binding]; other site
640081003773	catalytic residues [active]
640081003774	dimer interface [polypeptide binding]; other site
640081003775	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
640081003776	putative iron binding site [ion binding]; other site
640081003777	DsrE/DsrF-like family; Region: DrsE; cl00672
640081003778	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
640081003779	Transglycosylase; Region: Transgly; pfam00912
640081003780	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
640081003781	Cell division protein FtsA; Region: FtsA; cl17206
640081003782	Competence protein A; Region: Competence_A; pfam11104
640081003783	Cell division protein FtsA; Region: FtsA; pfam14450
640081003784	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
640081003785	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
640081003786	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
640081003787	Pilus assembly protein, PilO; Region: PilO; pfam04350
640081003788	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
640081003789	Pilus assembly protein, PilP; Region: PilP; pfam04351
640081003790	AMIN domain; Region: AMIN; pfam11741
640081003791	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
640081003792	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
640081003793	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
640081003794	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
640081003795	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
640081003796	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081003797	FeS/SAM binding site; other site
640081003798	TRAM domain; Region: TRAM; pfam01938
640081003799	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
640081003800	PhoH-like protein; Region: PhoH; pfam02562
640081003801	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
640081003802	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
640081003803	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
640081003804	Transporter associated domain; Region: CorC_HlyC; smart01091
640081003805	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
640081003806	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
640081003807	putative active site [active]
640081003808	catalytic triad [active]
640081003809	putative dimer interface [polypeptide binding]; other site
640081003810	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
640081003811	dimer interface [polypeptide binding]; other site
640081003812	motif 1; other site
640081003813	active site
640081003814	motif 2; other site
640081003815	motif 3; other site
640081003816	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
640081003817	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
640081003818	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
640081003819	active site
640081003820	motif I; other site
640081003821	motif II; other site
640081003822	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
640081003823	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
640081003824	putative acyl-acceptor binding pocket; other site
640081003825	Protein of unknown function DUF45; Region: DUF45; pfam01863
640081003826	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
640081003827	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
640081003828	dimer interface [polypeptide binding]; other site
640081003829	active site
640081003830	metal binding site [ion binding]; metal-binding site
640081003831	glutathione binding site [chemical binding]; other site
640081003832	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
640081003833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081003834	active site
640081003835	phosphorylation site [posttranslational modification]
640081003836	intermolecular recognition site; other site
640081003837	dimerization interface [polypeptide binding]; other site
640081003838	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
640081003839	active site
640081003840	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
640081003841	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
640081003842	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
640081003843	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
640081003844	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
640081003845	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081003846	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
640081003847	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081003848	DNA binding residues [nucleotide binding]
640081003849	DNA primase; Validated; Region: dnaG; PRK05667
640081003850	CHC2 zinc finger; Region: zf-CHC2; pfam01807
640081003851	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
640081003852	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
640081003853	active site
640081003854	metal binding site [ion binding]; metal-binding site
640081003855	interdomain interaction site; other site
640081003856	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
640081003857	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
640081003858	Yqey-like protein; Region: YqeY; pfam09424
640081003859	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
640081003860	UGMP family protein; Validated; Region: PRK09604
640081003861	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
640081003862	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
640081003863	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
640081003864	Dihydroneopterin aldolase; Region: FolB; smart00905
640081003865	active site
640081003866	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
640081003867	putative deacylase active site [active]
640081003868	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
640081003869	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
640081003870	active site
640081003871	Int/Topo IB signature motif; other site
640081003872	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
640081003873	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
640081003874	DNA binding site [nucleotide binding]
640081003875	active site
640081003876	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
640081003877	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
640081003878	putative catalytic cysteine [active]
640081003879	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
640081003880	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
640081003881	Lipopolysaccharide-assembly; Region: LptE; cl01125
640081003882	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
640081003883	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
640081003884	HIGH motif; other site
640081003885	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
640081003886	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
640081003887	active site
640081003888	KMSKS motif; other site
640081003889	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
640081003890	tRNA binding surface [nucleotide binding]; other site
640081003891	FecR protein; Region: FecR; pfam04773
640081003892	Sporulation related domain; Region: SPOR; pfam05036
640081003893	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
640081003894	Part of AAA domain; Region: AAA_19; pfam13245
640081003895	Family description; Region: UvrD_C_2; pfam13538
640081003896	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081003897	Zn2+ binding site [ion binding]; other site
640081003898	Mg2+ binding site [ion binding]; other site
640081003899	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
640081003900	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
640081003901	NADP binding site [chemical binding]; other site
640081003902	dimer interface [polypeptide binding]; other site
640081003903	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
640081003904	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
640081003905	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
640081003906	ParA-like protein; Provisional; Region: PHA02518
640081003907	P-loop; other site
640081003908	Magnesium ion binding site [ion binding]; other site
640081003909	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
640081003910	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
640081003911	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
640081003912	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
640081003913	peptidase PmbA; Provisional; Region: PRK11040
640081003914	hypothetical protein; Provisional; Region: PRK05255
640081003915	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
640081003916	MPT binding site; other site
640081003917	trimer interface [polypeptide binding]; other site
640081003918	thymidylate synthase; Reviewed; Region: thyA; PRK01827
640081003919	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
640081003920	dimerization interface [polypeptide binding]; other site
640081003921	active site
640081003922	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
640081003923	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
640081003924	active site
640081003925	dimer interface [polypeptide binding]; other site
640081003926	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
640081003927	dimer interface [polypeptide binding]; other site
640081003928	active site
640081003929	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
640081003930	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
640081003931	folate binding site [chemical binding]; other site
640081003932	NADP+ binding site [chemical binding]; other site
640081003933	FecR protein; Region: FecR; pfam04773
640081003934	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081003935	binding surface
640081003936	TPR motif; other site
640081003937	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
640081003938	FecR protein; Region: FecR; pfam04773
640081003939	Protein of unknown function (DUF560); Region: DUF560; pfam04575
640081003940	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
640081003941	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
640081003942	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
640081003943	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
640081003944	catalytic residue [active]
640081003945	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
640081003946	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
640081003947	trimer interface [polypeptide binding]; other site
640081003948	active site
640081003949	Domain of unknown function DUF59; Region: DUF59; pfam01883
640081003950	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
640081003951	Walker A motif; other site
640081003952	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
640081003953	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
640081003954	active site
640081003955	HIGH motif; other site
640081003956	KMSKS motif; other site
640081003957	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
640081003958	anticodon binding site; other site
640081003959	tRNA binding surface [nucleotide binding]; other site
640081003960	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
640081003961	dimer interface [polypeptide binding]; other site
640081003962	putative tRNA-binding site [nucleotide binding]; other site
640081003963	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
640081003964	putative transporter; Provisional; Region: PRK11660
640081003965	Sulfate transporter family; Region: Sulfate_transp; pfam00916
640081003966	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
640081003967	Acylphosphatase; Region: Acylphosphatase; pfam00708
640081003968	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
640081003969	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
640081003970	dimer interface [polypeptide binding]; other site
640081003971	decamer (pentamer of dimers) interface [polypeptide binding]; other site
640081003972	catalytic triad [active]
640081003973	peroxidatic and resolving cysteines [active]
640081003974	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
640081003975	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081003976	N-terminal plug; other site
640081003977	ligand-binding site [chemical binding]; other site
640081003978	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
640081003979	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
640081003980	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
640081003981	putative active site [active]
640081003982	putative PHP Thumb interface [polypeptide binding]; other site
640081003983	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
640081003984	generic binding surface II; other site
640081003985	generic binding surface I; other site
640081003986	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081003987	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
640081003988	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
640081003989	dimerization interface [polypeptide binding]; other site
640081003990	Pirin-related protein [General function prediction only]; Region: COG1741
640081003991	Pirin; Region: Pirin; pfam02678
640081003992	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
640081003993	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
640081003994	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
640081003995	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081003996	active site
640081003997	phosphorylation site [posttranslational modification]
640081003998	intermolecular recognition site; other site
640081003999	dimerization interface [polypeptide binding]; other site
640081004000	Response regulator receiver domain; Region: Response_reg; pfam00072
640081004001	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081004002	active site
640081004003	phosphorylation site [posttranslational modification]
640081004004	intermolecular recognition site; other site
640081004005	dimerization interface [polypeptide binding]; other site
640081004006	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
640081004007	DctM-like transporters; Region: DctM; pfam06808
640081004008	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
640081004009	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
640081004010	catalytic core [active]
640081004011	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
640081004012	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
640081004013	dimer interface [polypeptide binding]; other site
640081004014	active site
640081004015	glycine-pyridoxal phosphate binding site [chemical binding]; other site
640081004016	folate binding site [chemical binding]; other site
640081004017	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
640081004018	ATP cone domain; Region: ATP-cone; pfam03477
640081004019	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
640081004020	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
640081004021	catalytic motif [active]
640081004022	Zn binding site [ion binding]; other site
640081004023	RibD C-terminal domain; Region: RibD_C; cl17279
640081004024	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
640081004025	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
640081004026	ATP binding site [chemical binding]; other site
640081004027	substrate interface [chemical binding]; other site
640081004028	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
640081004029	C-terminal peptidase (prc); Region: prc; TIGR00225
640081004030	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
640081004031	protein binding site [polypeptide binding]; other site
640081004032	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
640081004033	Catalytic dyad [active]
640081004034	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
640081004035	Peptidase family M23; Region: Peptidase_M23; pfam01551
640081004036	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
640081004037	dimerization interface [polypeptide binding]; other site
640081004038	putative DNA binding site [nucleotide binding]; other site
640081004039	putative Zn2+ binding site [ion binding]; other site
640081004040	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
640081004041	active site residue [active]
640081004042	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
640081004043	GSH binding site [chemical binding]; other site
640081004044	catalytic residues [active]
640081004045	preprotein translocase subunit SecB; Validated; Region: PRK05751
640081004046	SecA binding site; other site
640081004047	Preprotein binding site; other site
640081004048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
640081004049	Src Homology 3 domain superfamily; Region: SH3; cl17036
640081004050	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
640081004051	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
640081004052	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
640081004053	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
640081004054	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
640081004055	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
640081004056	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
640081004057	Walker A motif; other site
640081004058	ATP binding site [chemical binding]; other site
640081004059	Walker B motif; other site
640081004060	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
640081004061	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
640081004062	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
640081004063	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
640081004064	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
640081004065	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
640081004066	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
640081004067	legume lectins; Region: lectin_L-type; cl14058
640081004068	homotetramer interaction site [polypeptide binding]; other site
640081004069	homodimer interaction site [polypeptide binding]; other site
640081004070	carbohydrate binding site [chemical binding]; other site
640081004071	metal binding site [ion binding]; metal-binding site
640081004072	Secretin and TonB N terminus short domain; Region: STN; pfam07660
640081004073	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
640081004074	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
640081004075	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
640081004076	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
640081004077	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081004078	Walker A motif; other site
640081004079	ATP binding site [chemical binding]; other site
640081004080	Walker B motif; other site
640081004081	arginine finger; other site
640081004082	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081004083	TPR motif; other site
640081004084	binding surface
640081004085	TPR repeat; Region: TPR_11; pfam13414
640081004086	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
640081004087	O-Antigen ligase; Region: Wzy_C; pfam04932
640081004088	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
640081004089	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
640081004090	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
640081004091	active site
640081004092	biotin synthase; Region: bioB; TIGR00433
640081004093	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081004094	FeS/SAM binding site; other site
640081004095	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
640081004096	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
640081004097	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081004098	S-adenosylmethionine binding site [chemical binding]; other site
640081004099	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
640081004100	TMAO/DMSO reductase; Reviewed; Region: PRK05363
640081004101	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
640081004102	Moco binding site; other site
640081004103	metal coordination site [ion binding]; other site
640081004104	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
640081004105	RNA polymerase sigma factor; Provisional; Region: PRK12511
640081004106	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081004107	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081004108	DNA binding residues [nucleotide binding]
640081004109	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
640081004110	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
640081004111	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
640081004112	Cytochrome c; Region: Cytochrom_C; cl11414
640081004113	Cytochrome c; Region: Cytochrom_C; cl11414
640081004114	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
640081004115	G1 box; other site
640081004116	GTP/Mg2+ binding site [chemical binding]; other site
640081004117	Switch I region; other site
640081004118	G2 box; other site
640081004119	G3 box; other site
640081004120	Switch II region; other site
640081004121	G4 box; other site
640081004122	G5 box; other site
640081004123	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
640081004124	dimer interface [polypeptide binding]; other site
640081004125	active site
640081004126	aspartate-rich active site metal binding site; other site
640081004127	allosteric magnesium binding site [ion binding]; other site
640081004128	Schiff base residues; other site
640081004129	division inhibitor protein; Provisional; Region: slmA; PRK09480
640081004130	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
640081004131	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
640081004132	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
640081004133	motif II; other site
640081004134	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
640081004135	feedback inhibition sensing region; other site
640081004136	homohexameric interface [polypeptide binding]; other site
640081004137	nucleotide binding site [chemical binding]; other site
640081004138	N-acetyl-L-glutamate binding site [chemical binding]; other site
640081004139	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
640081004140	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
640081004141	putative dimer interface [polypeptide binding]; other site
640081004142	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
640081004143	nudix motif; other site
640081004144	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
640081004145	RNAase interaction site [polypeptide binding]; other site
640081004146	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
640081004147	active site
640081004148	barstar interaction site; other site
640081004149	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
640081004150	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
640081004151	dimer interface [polypeptide binding]; other site
640081004152	anticodon binding site; other site
640081004153	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
640081004154	homodimer interface [polypeptide binding]; other site
640081004155	motif 1; other site
640081004156	active site
640081004157	motif 2; other site
640081004158	GAD domain; Region: GAD; pfam02938
640081004159	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
640081004160	motif 3; other site
640081004161	Uncharacterized conserved protein [Function unknown]; Region: COG2928
640081004162	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
640081004163	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
640081004164	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
640081004165	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
640081004166	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
640081004167	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
640081004168	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
640081004169	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
640081004170	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
640081004171	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
640081004172	Walker A motif; other site
640081004173	ATP binding site [chemical binding]; other site
640081004174	Walker B motif; other site
640081004175	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
640081004176	signal recognition particle protein; Provisional; Region: PRK10867
640081004177	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
640081004178	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
640081004179	P loop; other site
640081004180	GTP binding site [chemical binding]; other site
640081004181	Signal peptide binding domain; Region: SRP_SPB; pfam02978
640081004182	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
640081004183	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
640081004184	N-acetyl-D-glucosamine binding site [chemical binding]; other site
640081004185	catalytic residue [active]
640081004186	prolyl-tRNA synthetase; Provisional; Region: PRK09194
640081004187	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
640081004188	dimer interface [polypeptide binding]; other site
640081004189	motif 1; other site
640081004190	active site
640081004191	motif 2; other site
640081004192	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
640081004193	putative deacylase active site [active]
640081004194	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
640081004195	active site
640081004196	motif 3; other site
640081004197	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
640081004198	anticodon binding site; other site
640081004199	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
640081004200	putative active site [active]
640081004201	Ap4A binding site [chemical binding]; other site
640081004202	nudix motif; other site
640081004203	putative metal binding site [ion binding]; other site
640081004204	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
640081004205	CNP1-like family; Region: CNP1; pfam08750
640081004206	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
640081004207	diiron binding motif [ion binding]; other site
640081004208	OsmC-like protein; Region: OsmC; cl00767
640081004209	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
640081004210	23S rRNA interface [nucleotide binding]; other site
640081004211	L3 interface [polypeptide binding]; other site
640081004212	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
640081004213	Mnd1 family; Region: Mnd1; pfam03962
640081004214	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
640081004215	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
640081004216	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
640081004217	putative peptidase; Provisional; Region: PRK11649
640081004218	Peptidase family M23; Region: Peptidase_M23; pfam01551
640081004219	methionine sulfoxide reductase A; Provisional; Region: PRK14054
640081004220	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
640081004221	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
640081004222	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
640081004223	Epoxide hydrolase N terminus; Region: EHN; pfam06441
640081004224	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
640081004225	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
640081004226	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
640081004227	oligomer interface [polypeptide binding]; other site
640081004228	metal binding site [ion binding]; metal-binding site
640081004229	metal binding site [ion binding]; metal-binding site
640081004230	Cl binding site [ion binding]; other site
640081004231	aspartate ring; other site
640081004232	basic sphincter; other site
640081004233	putative hydrophobic gate; other site
640081004234	periplasmic entrance; other site
640081004235	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
640081004236	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
640081004237	putative ATP binding site [chemical binding]; other site
640081004238	putative substrate interface [chemical binding]; other site
640081004239	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
640081004240	putative binding surface; other site
640081004241	active site
640081004242	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081004243	Zn2+ binding site [ion binding]; other site
640081004244	Mg2+ binding site [ion binding]; other site
640081004245	Hemerythrin; Region: Hemerythrin; cd12107
640081004246	Fe binding site [ion binding]; other site
640081004247	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
640081004248	DEAD-like helicases superfamily; Region: DEXDc; smart00487
640081004249	ATP binding site [chemical binding]; other site
640081004250	Mg++ binding site [ion binding]; other site
640081004251	motif III; other site
640081004252	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
640081004253	nucleotide binding region [chemical binding]; other site
640081004254	ATP-binding site [chemical binding]; other site
640081004255	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
640081004256	putative RNA binding site [nucleotide binding]; other site
640081004257	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
640081004258	dimer interaction site [polypeptide binding]; other site
640081004259	substrate-binding tunnel; other site
640081004260	active site
640081004261	catalytic site [active]
640081004262	substrate binding site [chemical binding]; other site
640081004263	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
640081004264	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
640081004265	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
640081004266	DNA-binding site [nucleotide binding]; DNA binding site
640081004267	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081004268	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081004269	homodimer interface [polypeptide binding]; other site
640081004270	catalytic residue [active]
640081004271	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
640081004272	Peptidase family M23; Region: Peptidase_M23; pfam01551
640081004273	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
640081004274	active site
640081004275	dimer interface [polypeptide binding]; other site
640081004276	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081004277	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081004278	metal binding site [ion binding]; metal-binding site
640081004279	active site
640081004280	I-site; other site
640081004281	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
640081004282	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081004283	dimerization interface [polypeptide binding]; other site
640081004284	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
640081004285	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
640081004286	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
640081004287	active site
640081004288	HIGH motif; other site
640081004289	nucleotide binding site [chemical binding]; other site
640081004290	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
640081004291	active site
640081004292	KMSKS motif; other site
640081004293	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
640081004294	chromosome condensation membrane protein; Provisional; Region: PRK14196
640081004295	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
640081004296	EamA-like transporter family; Region: EamA; pfam00892
640081004297	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081004298	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
640081004299	dimerization interface [polypeptide binding]; other site
640081004300	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
640081004301	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081004302	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081004303	dimer interface [polypeptide binding]; other site
640081004304	putative CheW interface [polypeptide binding]; other site
640081004305	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
640081004306	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
640081004307	ATP binding site [chemical binding]; other site
640081004308	putative Mg++ binding site [ion binding]; other site
640081004309	nucleotide binding region [chemical binding]; other site
640081004310	helicase superfamily c-terminal domain; Region: HELICc; smart00490
640081004311	Helicase associated domain (HA2); Region: HA2; pfam04408
640081004312	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
640081004313	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
640081004314	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
640081004315	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
640081004316	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
640081004317	putative MPT binding site; other site
640081004318	Phasin protein; Region: Phasin_2; pfam09361
640081004319	Phasin protein; Region: Phasin_2; pfam09361
640081004320	enoyl-CoA hydratase; Provisional; Region: PRK05862
640081004321	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
640081004322	substrate binding site [chemical binding]; other site
640081004323	oxyanion hole (OAH) forming residues; other site
640081004324	trimer interface [polypeptide binding]; other site
640081004325	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
640081004326	OstA-like protein; Region: OstA; pfam03968
640081004327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
640081004328	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
640081004329	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
640081004330	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
640081004331	active site
640081004332	motif I; other site
640081004333	motif II; other site
640081004334	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
640081004335	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
640081004336	putative active site [active]
640081004337	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
640081004338	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
640081004339	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
640081004340	TrkA-N domain; Region: TrkA_N; pfam02254
640081004341	TrkA-C domain; Region: TrkA_C; pfam02080
640081004342	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081004343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081004344	ATP binding site [chemical binding]; other site
640081004345	Mg2+ binding site [ion binding]; other site
640081004346	G-X-G motif; other site
640081004347	Heme NO binding associated; Region: HNOBA; pfam07701
640081004348	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
640081004349	cyclase homology domain; Region: CHD; cd07302
640081004350	nucleotidyl binding site; other site
640081004351	metal binding site [ion binding]; metal-binding site
640081004352	dimer interface [polypeptide binding]; other site
640081004353	legume lectins; Region: lectin_L-type; cl14058
640081004354	carbohydrate binding site [chemical binding]; other site
640081004355	metal binding site [ion binding]; metal-binding site
640081004356	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
640081004357	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
640081004358	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
640081004359	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
640081004360	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
640081004361	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
640081004362	Walker A motif; other site
640081004363	ATP binding site [chemical binding]; other site
640081004364	Walker B motif; other site
640081004365	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081004366	binding surface
640081004367	TPR motif; other site
640081004368	Tetratricopeptide repeat; Region: TPR_16; pfam13432
640081004369	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
640081004370	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
640081004371	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
640081004372	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
640081004373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081004374	active site
640081004375	phosphorylation site [posttranslational modification]
640081004376	intermolecular recognition site; other site
640081004377	dimerization interface [polypeptide binding]; other site
640081004378	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081004379	Walker A motif; other site
640081004380	ATP binding site [chemical binding]; other site
640081004381	Walker B motif; other site
640081004382	arginine finger; other site
640081004383	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081004384	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
640081004385	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
640081004386	Walker A/P-loop; other site
640081004387	ATP binding site [chemical binding]; other site
640081004388	Q-loop/lid; other site
640081004389	ABC transporter signature motif; other site
640081004390	Walker B; other site
640081004391	D-loop; other site
640081004392	H-loop/switch region; other site
640081004393	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
640081004394	Permease; Region: Permease; pfam02405
640081004395	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
640081004396	mce related protein; Region: MCE; pfam02470
640081004397	VacJ like lipoprotein; Region: VacJ; cl01073
640081004398	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
640081004399	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
640081004400	anti sigma factor interaction site; other site
640081004401	regulatory phosphorylation site [posttranslational modification]; other site
640081004402	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
640081004403	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
640081004404	Walker A/P-loop; other site
640081004405	ATP binding site [chemical binding]; other site
640081004406	Q-loop/lid; other site
640081004407	ABC transporter signature motif; other site
640081004408	Walker B; other site
640081004409	D-loop; other site
640081004410	H-loop/switch region; other site
640081004411	ABC-2 type transporter; Region: ABC2_membrane; cl17235
640081004412	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
640081004413	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
640081004414	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
640081004415	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
640081004416	hinge; other site
640081004417	active site
640081004418	NifZ domain; Region: NifZ; pfam04319
640081004419	Cation efflux family; Region: Cation_efflux; pfam01545
640081004420	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
640081004421	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
640081004422	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
640081004423	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
640081004424	NAD binding site [chemical binding]; other site
640081004425	dimerization interface [polypeptide binding]; other site
640081004426	product binding site; other site
640081004427	substrate binding site [chemical binding]; other site
640081004428	zinc binding site [ion binding]; other site
640081004429	catalytic residues [active]
640081004430	Chromate transporter; Region: Chromate_transp; pfam02417
640081004431	Chromate transporter; Region: Chromate_transp; pfam02417
640081004432	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
640081004433	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081004434	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081004435	homodimer interface [polypeptide binding]; other site
640081004436	catalytic residue [active]
640081004437	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
640081004438	putative active site pocket [active]
640081004439	4-fold oligomerization interface [polypeptide binding]; other site
640081004440	metal binding residues [ion binding]; metal-binding site
640081004441	3-fold/trimer interface [polypeptide binding]; other site
640081004442	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
640081004443	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
640081004444	putative active site [active]
640081004445	oxyanion strand; other site
640081004446	catalytic triad [active]
640081004447	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
640081004448	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
640081004449	catalytic residues [active]
640081004450	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
640081004451	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
640081004452	substrate binding site [chemical binding]; other site
640081004453	glutamase interaction surface [polypeptide binding]; other site
640081004454	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
640081004455	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
640081004456	metal binding site [ion binding]; metal-binding site
640081004457	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
640081004458	nucleotide binding site/active site [active]
640081004459	HIT family signature motif; other site
640081004460	catalytic residue [active]
640081004461	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
640081004462	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
640081004463	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
640081004464	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
640081004465	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
640081004466	putative active site [active]
640081004467	putative dimer interface [polypeptide binding]; other site
640081004468	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
640081004469	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
640081004470	protein binding site [polypeptide binding]; other site
640081004471	Uncharacterized conserved protein [Function unknown]; Region: COG0327
640081004472	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
640081004473	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
640081004474	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
640081004475	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081004476	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
640081004477	putative active site [active]
640081004478	heme pocket [chemical binding]; other site
640081004479	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081004480	putative active site [active]
640081004481	heme pocket [chemical binding]; other site
640081004482	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081004483	putative active site [active]
640081004484	heme pocket [chemical binding]; other site
640081004485	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081004486	metal binding site [ion binding]; metal-binding site
640081004487	active site
640081004488	I-site; other site
640081004489	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081004490	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081004491	PAS domain; Region: PAS_9; pfam13426
640081004492	putative active site [active]
640081004493	heme pocket [chemical binding]; other site
640081004494	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081004495	metal binding site [ion binding]; metal-binding site
640081004496	active site
640081004497	I-site; other site
640081004498	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
640081004499	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
640081004500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081004501	active site
640081004502	phosphorylation site [posttranslational modification]
640081004503	intermolecular recognition site; other site
640081004504	dimerization interface [polypeptide binding]; other site
640081004505	CheB methylesterase; Region: CheB_methylest; pfam01339
640081004506	CheD chemotactic sensory transduction; Region: CheD; cl00810
640081004507	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
640081004508	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
640081004509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081004510	S-adenosylmethionine binding site [chemical binding]; other site
640081004511	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
640081004512	putative CheA interaction surface; other site
640081004513	CHASE3 domain; Region: CHASE3; cl05000
640081004514	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
640081004515	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081004516	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081004517	dimerization interface [polypeptide binding]; other site
640081004518	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081004519	dimer interface [polypeptide binding]; other site
640081004520	putative CheW interface [polypeptide binding]; other site
640081004521	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
640081004522	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
640081004523	putative binding surface; other site
640081004524	active site
640081004525	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
640081004526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081004527	ATP binding site [chemical binding]; other site
640081004528	Mg2+ binding site [ion binding]; other site
640081004529	G-X-G motif; other site
640081004530	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
640081004531	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
640081004532	anti sigma factor interaction site; other site
640081004533	regulatory phosphorylation site [posttranslational modification]; other site
640081004534	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081004535	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081004536	dimer interface [polypeptide binding]; other site
640081004537	putative CheW interface [polypeptide binding]; other site
640081004538	Response regulator receiver domain; Region: Response_reg; pfam00072
640081004539	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081004540	active site
640081004541	phosphorylation site [posttranslational modification]
640081004542	intermolecular recognition site; other site
640081004543	dimerization interface [polypeptide binding]; other site
640081004544	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
640081004545	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
640081004546	acyl-activating enzyme (AAE) consensus motif; other site
640081004547	AMP binding site [chemical binding]; other site
640081004548	active site
640081004549	CoA binding site [chemical binding]; other site
640081004550	multidrug efflux protein; Reviewed; Region: PRK01766
640081004551	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
640081004552	cation binding site [ion binding]; other site
640081004553	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
640081004554	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
640081004555	acyl-activating enzyme (AAE) consensus motif; other site
640081004556	AMP binding site [chemical binding]; other site
640081004557	active site
640081004558	CoA binding site [chemical binding]; other site
640081004559	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
640081004560	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
640081004561	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
640081004562	CoA-ligase; Region: Ligase_CoA; pfam00549
640081004563	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
640081004564	CoA binding domain; Region: CoA_binding; smart00881
640081004565	CoA-ligase; Region: Ligase_CoA; pfam00549
640081004566	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
640081004567	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
640081004568	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
640081004569	CHASE2 domain; Region: CHASE2; pfam05226
640081004570	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
640081004571	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
640081004572	active site
640081004573	ATP binding site [chemical binding]; other site
640081004574	substrate binding site [chemical binding]; other site
640081004575	activation loop (A-loop); other site
640081004576	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
640081004577	Protein phosphatase 2C; Region: PP2C; pfam00481
640081004578	active site
640081004579	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
640081004580	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
640081004581	phosphopeptide binding site; other site
640081004582	CHASE2 domain; Region: CHASE2; pfam05226
640081004583	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
640081004584	cyclase homology domain; Region: CHD; cd07302
640081004585	nucleotidyl binding site; other site
640081004586	metal binding site [ion binding]; metal-binding site
640081004587	dimer interface [polypeptide binding]; other site
640081004588	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
640081004589	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081004590	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081004591	ligand binding site [chemical binding]; other site
640081004592	flexible hinge region; other site
640081004593	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
640081004594	active site residue [active]
640081004595	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
640081004596	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
640081004597	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
640081004598	Type II/IV secretion system protein; Region: T2SE; pfam00437
640081004599	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
640081004600	Walker A motif; other site
640081004601	ATP binding site [chemical binding]; other site
640081004602	Walker B motif; other site
640081004603	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
640081004604	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
640081004605	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081004606	Zn2+ binding site [ion binding]; other site
640081004607	Mg2+ binding site [ion binding]; other site
640081004608	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081004609	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
640081004610	Pilin (bacterial filament); Region: Pilin; pfam00114
640081004611	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
640081004612	catalytic core [active]
640081004613	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
640081004614	putative active site [active]
640081004615	putative metal binding residues [ion binding]; other site
640081004616	signature motif; other site
640081004617	putative triphosphate binding site [ion binding]; other site
640081004618	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
640081004619	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081004620	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081004621	ligand binding site [chemical binding]; other site
640081004622	flexible hinge region; other site
640081004623	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
640081004624	putative switch regulator; other site
640081004625	non-specific DNA interactions [nucleotide binding]; other site
640081004626	DNA binding site [nucleotide binding]
640081004627	sequence specific DNA binding site [nucleotide binding]; other site
640081004628	putative cAMP binding site [chemical binding]; other site
640081004629	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
640081004630	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081004631	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
640081004632	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
640081004633	Walker A/P-loop; other site
640081004634	ATP binding site [chemical binding]; other site
640081004635	Q-loop/lid; other site
640081004636	ABC transporter signature motif; other site
640081004637	Walker B; other site
640081004638	D-loop; other site
640081004639	H-loop/switch region; other site
640081004640	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
640081004641	GAF domain; Region: GAF; pfam01590
640081004642	PAS domain; Region: PAS; smart00091
640081004643	putative active site [active]
640081004644	heme pocket [chemical binding]; other site
640081004645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081004646	Walker A motif; other site
640081004647	ATP binding site [chemical binding]; other site
640081004648	Walker B motif; other site
640081004649	arginine finger; other site
640081004650	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081004651	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
640081004652	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
640081004653	NAD(P) binding site [chemical binding]; other site
640081004654	catalytic residues [active]
640081004655	hypothetical protein; Validated; Region: PRK00029
640081004656	Uncharacterized conserved protein [Function unknown]; Region: COG0397
640081004657	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
640081004658	FtsX-like permease family; Region: FtsX; pfam02687
640081004659	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
640081004660	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
640081004661	FtsX-like permease family; Region: FtsX; pfam02687
640081004662	LabA_like proteins; Region: LabA_like; cd06167
640081004663	putative metal binding site [ion binding]; other site
640081004664	Uncharacterized conserved protein [Function unknown]; Region: COG1432
640081004665	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879
640081004666	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
640081004667	tetramerization interface [polypeptide binding]; other site
640081004668	active site
640081004669	pantoate--beta-alanine ligase; Region: panC; TIGR00018
640081004670	Pantoate-beta-alanine ligase; Region: PanC; cd00560
640081004671	active site
640081004672	ATP-binding site [chemical binding]; other site
640081004673	pantoate-binding site; other site
640081004674	HXXH motif; other site
640081004675	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
640081004676	oligomerization interface [polypeptide binding]; other site
640081004677	active site
640081004678	metal binding site [ion binding]; metal-binding site
640081004679	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
640081004680	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
640081004681	Substrate-binding site [chemical binding]; other site
640081004682	Substrate specificity [chemical binding]; other site
640081004683	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081004684	dimer interface [polypeptide binding]; other site
640081004685	putative CheW interface [polypeptide binding]; other site
640081004686	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
640081004687	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
640081004688	DNA binding site [nucleotide binding]
640081004689	active site
640081004690	Int/Topo IB signature motif; other site
640081004691	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
640081004692	active site
640081004693	catalytic residues [active]
640081004694	DNA binding site [nucleotide binding]
640081004695	Int/Topo IB signature motif; other site
640081004696	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
640081004697	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
640081004698	Domain of unknown function (DUF955); Region: DUF955; cl01076
640081004699	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
640081004700	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
640081004701	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
640081004702	PLD-like domain; Region: PLDc_2; pfam13091
640081004703	homodimer interface [polypeptide binding]; other site
640081004704	putative active site [active]
640081004705	catalytic site [active]
640081004706	Helix-turn-helix domain; Region: HTH_17; pfam12728
640081004707	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
640081004708	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
640081004709	putative dimer interface [polypeptide binding]; other site
640081004710	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
640081004711	Clp amino terminal domain; Region: Clp_N; pfam02861
640081004712	Clp amino terminal domain; Region: Clp_N; pfam02861
640081004713	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081004714	Walker A motif; other site
640081004715	ATP binding site [chemical binding]; other site
640081004716	Walker B motif; other site
640081004717	arginine finger; other site
640081004718	CHD5-like protein; Region: CHD5; pfam04420
640081004719	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081004720	Walker A motif; other site
640081004721	ATP binding site [chemical binding]; other site
640081004722	Walker B motif; other site
640081004723	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
640081004724	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
640081004725	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
640081004726	putative active site [active]
640081004727	catalytic site [active]
640081004728	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
640081004729	putative active site [active]
640081004730	catalytic site [active]
640081004731	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
640081004732	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081004733	Walker A motif; other site
640081004734	ATP binding site [chemical binding]; other site
640081004735	Walker B motif; other site
640081004736	arginine finger; other site
640081004737	Peptidase family M41; Region: Peptidase_M41; pfam01434
640081004738	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
640081004739	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
640081004740	putative dimer interface [polypeptide binding]; other site
640081004741	YfdX protein; Region: YfdX; pfam10938
640081004742	YfdX protein; Region: YfdX; pfam10938
640081004743	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
640081004744	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
640081004745	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
640081004746	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
640081004747	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
640081004748	catalytic residues [active]
640081004749	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081004750	PAS fold; Region: PAS_3; pfam08447
640081004751	putative active site [active]
640081004752	heme pocket [chemical binding]; other site
640081004753	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081004754	PAS fold; Region: PAS_3; pfam08447
640081004755	putative active site [active]
640081004756	heme pocket [chemical binding]; other site
640081004757	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081004758	PAS domain; Region: PAS_9; pfam13426
640081004759	putative active site [active]
640081004760	heme pocket [chemical binding]; other site
640081004761	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081004762	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081004763	metal binding site [ion binding]; metal-binding site
640081004764	active site
640081004765	I-site; other site
640081004766	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081004767	Phosphate-starvation-inducible E; Region: PsiE; cl01264
640081004768	Peptidase family M48; Region: Peptidase_M48; cl12018
640081004769	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
640081004770	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
640081004771	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
640081004772	protein binding site [polypeptide binding]; other site
640081004773	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
640081004774	catalytic residues [active]
640081004775	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
640081004776	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
640081004777	Integrase core domain; Region: rve; pfam00665
640081004778	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
640081004779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081004780	Walker A motif; other site
640081004781	ATP binding site [chemical binding]; other site
640081004782	Walker B motif; other site
640081004783	arginine finger; other site
640081004784	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
640081004785	Helix-turn-helix domain; Region: HTH_38; pfam13936
640081004786	Homeodomain-like domain; Region: HTH_32; pfam13565
640081004787	Integrase core domain; Region: rve; pfam00665
640081004788	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
640081004789	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
640081004790	transmembrane helices; other site
640081004791	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
640081004792	catalytic center binding site [active]
640081004793	ATP binding site [chemical binding]; other site
640081004794	poly(A) polymerase; Region: pcnB; TIGR01942
640081004795	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
640081004796	active site
640081004797	NTP binding site [chemical binding]; other site
640081004798	metal binding triad [ion binding]; metal-binding site
640081004799	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
640081004800	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
640081004801	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
640081004802	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
640081004803	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
640081004804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081004805	Walker A motif; other site
640081004806	ATP binding site [chemical binding]; other site
640081004807	Walker B motif; other site
640081004808	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
640081004809	arginine finger; other site
640081004810	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
640081004811	Domain of unknown function DUF20; Region: UPF0118; pfam01594
640081004812	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
640081004813	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
640081004814	dimerization interface [polypeptide binding]; other site
640081004815	putative ATP binding site [chemical binding]; other site
640081004816	Cytochrome c; Region: Cytochrom_C; cl11414
640081004817	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
640081004818	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
640081004819	active site
640081004820	ATP binding site [chemical binding]; other site
640081004821	substrate binding site [chemical binding]; other site
640081004822	activation loop (A-loop); other site
640081004823	PEGA domain; Region: PEGA; pfam08308
640081004824	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
640081004825	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
640081004826	putative substrate translocation pore; other site
640081004827	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
640081004828	MarR family; Region: MarR_2; pfam12802
640081004829	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
640081004830	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
640081004831	substrate binding pocket [chemical binding]; other site
640081004832	membrane-bound complex binding site; other site
640081004833	hinge residues; other site
640081004834	sensor protein RstB; Provisional; Region: PRK10604
640081004835	HAMP domain; Region: HAMP; pfam00672
640081004836	dimerization interface [polypeptide binding]; other site
640081004837	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081004838	dimer interface [polypeptide binding]; other site
640081004839	phosphorylation site [posttranslational modification]
640081004840	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081004841	ATP binding site [chemical binding]; other site
640081004842	Mg2+ binding site [ion binding]; other site
640081004843	G-X-G motif; other site
640081004844	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
640081004845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081004846	active site
640081004847	phosphorylation site [posttranslational modification]
640081004848	intermolecular recognition site; other site
640081004849	dimerization interface [polypeptide binding]; other site
640081004850	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081004851	DNA binding site [nucleotide binding]
640081004852	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081004853	PAS domain; Region: PAS_9; pfam13426
640081004854	putative active site [active]
640081004855	heme pocket [chemical binding]; other site
640081004856	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081004857	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081004858	metal binding site [ion binding]; metal-binding site
640081004859	active site
640081004860	I-site; other site
640081004861	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081004862	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
640081004863	Fatty acid desaturase; Region: FA_desaturase; pfam00487
640081004864	Di-iron ligands [ion binding]; other site
640081004865	Transposase; Region: DDE_Tnp_ISL3; pfam01610
640081004866	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
640081004867	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
640081004868	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
640081004869	PilZ domain; Region: PilZ; pfam07238
640081004870	hypothetical protein; Reviewed; Region: PRK00024
640081004871	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
640081004872	MPN+ (JAMM) motif; other site
640081004873	Zinc-binding site [ion binding]; other site
640081004874	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
640081004875	Flavoprotein; Region: Flavoprotein; pfam02441
640081004876	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
640081004877	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
640081004878	trimer interface [polypeptide binding]; other site
640081004879	active site
640081004880	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
640081004881	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
640081004882	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
640081004883	Cytochrome c; Region: Cytochrom_C; cl11414
640081004884	Mechanosensitive ion channel; Region: MS_channel; pfam00924
640081004885	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
640081004886	ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563
640081004887	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
640081004888	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
640081004889	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
640081004890	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
640081004891	active site
640081004892	substrate binding site [chemical binding]; other site
640081004893	cosubstrate binding site; other site
640081004894	catalytic site [active]
640081004895	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
640081004896	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
640081004897	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
640081004898	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081004899	active site
640081004900	phosphorylation site [posttranslational modification]
640081004901	intermolecular recognition site; other site
640081004902	dimerization interface [polypeptide binding]; other site
640081004903	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
640081004904	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
640081004905	substrate binding pocket [chemical binding]; other site
640081004906	membrane-bound complex binding site; other site
640081004907	hinge residues; other site
640081004908	PAS domain S-box; Region: sensory_box; TIGR00229
640081004909	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081004910	putative active site [active]
640081004911	heme pocket [chemical binding]; other site
640081004912	PAS fold; Region: PAS_4; pfam08448
640081004913	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081004914	putative active site [active]
640081004915	heme pocket [chemical binding]; other site
640081004916	GAF domain; Region: GAF; pfam01590
640081004917	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081004918	dimer interface [polypeptide binding]; other site
640081004919	phosphorylation site [posttranslational modification]
640081004920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081004921	ATP binding site [chemical binding]; other site
640081004922	Mg2+ binding site [ion binding]; other site
640081004923	G-X-G motif; other site
640081004924	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
640081004925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081004926	active site
640081004927	phosphorylation site [posttranslational modification]
640081004928	intermolecular recognition site; other site
640081004929	dimerization interface [polypeptide binding]; other site
640081004930	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081004931	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081004932	metal binding site [ion binding]; metal-binding site
640081004933	active site
640081004934	I-site; other site
640081004935	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081004936	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
640081004937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081004938	ATP binding site [chemical binding]; other site
640081004939	Mg2+ binding site [ion binding]; other site
640081004940	G-X-G motif; other site
640081004941	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
640081004942	ATP binding site [chemical binding]; other site
640081004943	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
640081004944	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
640081004945	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
640081004946	TfoX N-terminal domain; Region: TfoX_N; pfam04993
640081004947	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
640081004948	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081004949	dimerization interface [polypeptide binding]; other site
640081004950	PAS domain S-box; Region: sensory_box; TIGR00229
640081004951	PAS domain; Region: PAS; smart00091
640081004952	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
640081004953	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081004954	putative active site [active]
640081004955	heme pocket [chemical binding]; other site
640081004956	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081004957	dimer interface [polypeptide binding]; other site
640081004958	phosphorylation site [posttranslational modification]
640081004959	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081004960	ATP binding site [chemical binding]; other site
640081004961	Mg2+ binding site [ion binding]; other site
640081004962	G-X-G motif; other site
640081004963	Response regulator receiver domain; Region: Response_reg; pfam00072
640081004964	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081004965	active site
640081004966	phosphorylation site [posttranslational modification]
640081004967	intermolecular recognition site; other site
640081004968	dimerization interface [polypeptide binding]; other site
640081004969	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
640081004970	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
640081004971	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
640081004972	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081004973	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
640081004974	Phosphoglycerate kinase; Region: PGK; pfam00162
640081004975	substrate binding site [chemical binding]; other site
640081004976	hinge regions; other site
640081004977	ADP binding site [chemical binding]; other site
640081004978	catalytic site [active]
640081004979	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
640081004980	erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532
640081004981	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
640081004982	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
640081004983	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
640081004984	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
640081004985	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
640081004986	transketolase; Reviewed; Region: PRK12753
640081004987	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
640081004988	TPP-binding site [chemical binding]; other site
640081004989	dimer interface [polypeptide binding]; other site
640081004990	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
640081004991	PYR/PP interface [polypeptide binding]; other site
640081004992	dimer interface [polypeptide binding]; other site
640081004993	TPP binding site [chemical binding]; other site
640081004994	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
640081004995	phosphoribulokinase; Provisional; Region: PRK15453
640081004996	fructose-1,6-bisphosphatase family protein; Region: PLN02628
640081004997	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
640081004998	AMP binding site [chemical binding]; other site
640081004999	metal binding site [ion binding]; metal-binding site
640081005000	active site
640081005001	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081005002	PAS fold; Region: PAS_3; pfam08447
640081005003	putative active site [active]
640081005004	heme pocket [chemical binding]; other site
640081005005	PAS domain; Region: PAS; smart00091
640081005006	PAS fold; Region: PAS_7; pfam12860
640081005007	PAS fold; Region: PAS_7; pfam12860
640081005008	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081005009	PAS domain; Region: PAS_9; pfam13426
640081005010	putative active site [active]
640081005011	heme pocket [chemical binding]; other site
640081005012	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081005013	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081005014	metal binding site [ion binding]; metal-binding site
640081005015	active site
640081005016	I-site; other site
640081005017	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081005018	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
640081005019	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081005020	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081005021	metal binding site [ion binding]; metal-binding site
640081005022	active site
640081005023	I-site; other site
640081005024	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081005025	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
640081005026	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
640081005027	active site
640081005028	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
640081005029	putative catalytic residue [active]
640081005030	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
640081005031	RNA methyltransferase, RsmE family; Region: TIGR00046
640081005032	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
640081005033	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
640081005034	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
640081005035	N-acetylglutamate synthase; Validated; Region: PRK05279
640081005036	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
640081005037	putative feedback inhibition sensing region; other site
640081005038	putative nucleotide binding site [chemical binding]; other site
640081005039	putative substrate binding site [chemical binding]; other site
640081005040	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
640081005041	Coenzyme A binding pocket [chemical binding]; other site
640081005042	oxidative damage protection protein; Provisional; Region: PRK05408
640081005043	transcriptional regulator PhoU; Provisional; Region: PRK11115
640081005044	PhoU domain; Region: PhoU; pfam01895
640081005045	PhoU domain; Region: PhoU; pfam01895
640081005046	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
640081005047	tetramer (dimer of dimers) interface [polypeptide binding]; other site
640081005048	active site
640081005049	dimer interface [polypeptide binding]; other site
640081005050	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
640081005051	E3 interaction surface; other site
640081005052	lipoyl attachment site [posttranslational modification]; other site
640081005053	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
640081005054	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
640081005055	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
640081005056	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
640081005057	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
640081005058	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
640081005059	E3 interaction surface; other site
640081005060	lipoyl attachment site [posttranslational modification]; other site
640081005061	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
640081005062	E3 interaction surface; other site
640081005063	lipoyl attachment site [posttranslational modification]; other site
640081005064	e3 binding domain; Region: E3_binding; pfam02817
640081005065	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
640081005066	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
640081005067	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
640081005068	dimer interface [polypeptide binding]; other site
640081005069	TPP-binding site [chemical binding]; other site
640081005070	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
640081005071	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
640081005072	putative ligand binding site [chemical binding]; other site
640081005073	PAS domain; Region: PAS_9; pfam13426
640081005074	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081005075	putative active site [active]
640081005076	heme pocket [chemical binding]; other site
640081005077	PAS domain S-box; Region: sensory_box; TIGR00229
640081005078	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081005079	putative active site [active]
640081005080	heme pocket [chemical binding]; other site
640081005081	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
640081005082	PAS domain; Region: PAS_8; pfam13188
640081005083	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081005084	dimer interface [polypeptide binding]; other site
640081005085	phosphorylation site [posttranslational modification]
640081005086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081005087	ATP binding site [chemical binding]; other site
640081005088	Mg2+ binding site [ion binding]; other site
640081005089	G-X-G motif; other site
640081005090	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
640081005091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005092	active site
640081005093	phosphorylation site [posttranslational modification]
640081005094	intermolecular recognition site; other site
640081005095	dimerization interface [polypeptide binding]; other site
640081005096	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
640081005097	DNA binding residues [nucleotide binding]
640081005098	dimerization interface [polypeptide binding]; other site
640081005099	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
640081005100	Cysteine-rich domain; Region: CCG; pfam02754
640081005101	Cysteine-rich domain; Region: CCG; pfam02754
640081005102	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
640081005103	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
640081005104	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
640081005105	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
640081005106	Uncharacterized conserved protein [Function unknown]; Region: COG1556
640081005107	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
640081005108	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
640081005109	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
640081005110	SurA N-terminal domain; Region: SurA_N; pfam09312
640081005111	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
640081005112	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
640081005113	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
640081005114	Organic solvent tolerance protein; Region: OstA_C; pfam04453
640081005115	Phosphotransferase enzyme family; Region: APH; pfam01636
640081005116	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
640081005117	active site
640081005118	ATP binding site [chemical binding]; other site
640081005119	substrate binding site [chemical binding]; other site
640081005120	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
640081005121	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
640081005122	Substrate binding site; other site
640081005123	metal-binding site
640081005124	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
640081005125	proline aminopeptidase P II; Provisional; Region: PRK10879
640081005126	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
640081005127	active site
640081005128	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
640081005129	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
640081005130	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
640081005131	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
640081005132	FMN binding site [chemical binding]; other site
640081005133	active site
640081005134	catalytic residues [active]
640081005135	substrate binding site [chemical binding]; other site
640081005136	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
640081005137	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
640081005138	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
640081005139	purine monophosphate binding site [chemical binding]; other site
640081005140	dimer interface [polypeptide binding]; other site
640081005141	putative catalytic residues [active]
640081005142	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
640081005143	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
640081005144	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
640081005145	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
640081005146	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
640081005147	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
640081005148	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
640081005149	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
640081005150	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
640081005151	HemY protein N-terminus; Region: HemY_N; pfam07219
640081005152	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
640081005153	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
640081005154	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
640081005155	active site
640081005156	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
640081005157	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
640081005158	domain interfaces; other site
640081005159	active site
640081005160	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
640081005161	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
640081005162	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
640081005163	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
640081005164	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
640081005165	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
640081005166	acyl-activating enzyme (AAE) consensus motif; other site
640081005167	acyl-activating enzyme (AAE) consensus motif; other site
640081005168	putative AMP binding site [chemical binding]; other site
640081005169	putative active site [active]
640081005170	putative CoA binding site [chemical binding]; other site
640081005171	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
640081005172	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
640081005173	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
640081005174	protein binding site [polypeptide binding]; other site
640081005175	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
640081005176	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
640081005177	active site residue [active]
640081005178	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081005179	S-adenosylmethionine binding site [chemical binding]; other site
640081005180	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
640081005181	Cytochrome c; Region: Cytochrom_C; cl11414
640081005182	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
640081005183	Cytochrome c; Region: Cytochrom_C; cl11414
640081005184	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
640081005185	putative FMN binding site [chemical binding]; other site
640081005186	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
640081005187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005188	active site
640081005189	phosphorylation site [posttranslational modification]
640081005190	intermolecular recognition site; other site
640081005191	dimerization interface [polypeptide binding]; other site
640081005192	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
640081005193	DNA binding site [nucleotide binding]
640081005194	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081005195	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081005196	dimer interface [polypeptide binding]; other site
640081005197	phosphorylation site [posttranslational modification]
640081005198	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081005199	G-X-G motif; other site
640081005200	putative metal dependent hydrolase; Provisional; Region: PRK11598
640081005201	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
640081005202	Sulfatase; Region: Sulfatase; pfam00884
640081005203	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
640081005204	active site
640081005205	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
640081005206	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
640081005207	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
640081005208	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
640081005209	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
640081005210	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
640081005211	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
640081005212	NAD binding site [chemical binding]; other site
640081005213	homodimer interface [polypeptide binding]; other site
640081005214	homotetramer interface [polypeptide binding]; other site
640081005215	active site
640081005216	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
640081005217	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
640081005218	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
640081005219	metal-binding site [ion binding]
640081005220	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
640081005221	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
640081005222	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
640081005223	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
640081005224	Low-spin heme binding site [chemical binding]; other site
640081005225	Putative water exit pathway; other site
640081005226	Binuclear center (active site) [active]
640081005227	Putative proton exit pathway; other site
640081005228	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
640081005229	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
640081005230	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
640081005231	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
640081005232	Cytochrome c; Region: Cytochrom_C; pfam00034
640081005233	Cytochrome c; Region: Cytochrom_C; pfam00034
640081005234	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
640081005235	4Fe-4S binding domain; Region: Fer4_5; pfam12801
640081005236	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
640081005237	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
640081005238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
640081005239	FixH; Region: FixH; pfam05751
640081005240	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
640081005241	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
640081005242	Ligand Binding Site [chemical binding]; other site
640081005243	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
640081005244	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
640081005245	Beta-Casp domain; Region: Beta-Casp; smart01027
640081005246	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
640081005247	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
640081005248	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
640081005249	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
640081005250	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
640081005251	FMN binding site [chemical binding]; other site
640081005252	substrate binding site [chemical binding]; other site
640081005253	putative catalytic residue [active]
640081005254	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
640081005255	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
640081005256	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
640081005257	Hemerythrin-like domain; Region: Hr-like; cd12108
640081005258	Fe binding site [ion binding]; other site
640081005259	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
640081005260	CPxP  motif; other site
640081005261	NnrS protein; Region: NnrS; pfam05940
640081005262	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
640081005263	Hemerythrin-like domain; Region: Hr-like; cd12108
640081005264	Fe binding site [ion binding]; other site
640081005265	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
640081005266	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081005267	ligand binding site [chemical binding]; other site
640081005268	flexible hinge region; other site
640081005269	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
640081005270	putative switch regulator; other site
640081005271	non-specific DNA interactions [nucleotide binding]; other site
640081005272	DNA binding site [nucleotide binding]
640081005273	sequence specific DNA binding site [nucleotide binding]; other site
640081005274	putative cAMP binding site [chemical binding]; other site
640081005275	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
640081005276	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081005277	FeS/SAM binding site; other site
640081005278	HemN C-terminal domain; Region: HemN_C; pfam06969
640081005279	Family description; Region: DsbD_2; pfam13386
640081005280	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
640081005281	Ligand Binding Site [chemical binding]; other site
640081005282	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
640081005283	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
640081005284	metal-binding site [ion binding]
640081005285	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
640081005286	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
640081005287	metal-binding site [ion binding]
640081005288	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
640081005289	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
640081005290	metal-binding site [ion binding]
640081005291	FeoA domain; Region: FeoA; pfam04023
640081005292	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
640081005293	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
640081005294	G1 box; other site
640081005295	GTP/Mg2+ binding site [chemical binding]; other site
640081005296	G2 box; other site
640081005297	Switch I region; other site
640081005298	G3 box; other site
640081005299	Switch II region; other site
640081005300	G4 box; other site
640081005301	G5 box; other site
640081005302	Nucleoside recognition; Region: Gate; pfam07670
640081005303	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
640081005304	Nucleoside recognition; Region: Gate; pfam07670
640081005305	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
640081005306	4Fe-4S binding domain; Region: Fer4_5; pfam12801
640081005307	Iron permease FTR1 family; Region: FTR1; cl00475
640081005308	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
640081005309	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
640081005310	Fe2+ transport protein; Region: Iron_transport; pfam10634
640081005311	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
640081005312	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
640081005313	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
640081005314	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081005315	N-terminal plug; other site
640081005316	ligand-binding site [chemical binding]; other site
640081005317	Flavodoxin; Region: Flavodoxin_1; pfam00258
640081005318	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
640081005319	FAD binding pocket [chemical binding]; other site
640081005320	FAD binding motif [chemical binding]; other site
640081005321	catalytic residues [active]
640081005322	NAD binding pocket [chemical binding]; other site
640081005323	phosphate binding motif [ion binding]; other site
640081005324	beta-alpha-beta structure motif; other site
640081005325	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
640081005326	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
640081005327	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
640081005328	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
640081005329	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
640081005330	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
640081005331	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
640081005332	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081005333	N-terminal plug; other site
640081005334	ligand-binding site [chemical binding]; other site
640081005335	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
640081005336	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
640081005337	active site
640081005338	substrate binding site [chemical binding]; other site
640081005339	FMN binding site [chemical binding]; other site
640081005340	putative catalytic residues [active]
640081005341	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
640081005342	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
640081005343	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
640081005344	protein binding site [polypeptide binding]; other site
640081005345	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
640081005346	protein binding site [polypeptide binding]; other site
640081005347	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
640081005348	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
640081005349	Secretin and TonB N terminus short domain; Region: STN; smart00965
640081005350	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
640081005351	FecR protein; Region: FecR; pfam04773
640081005352	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081005353	RNA polymerase sigma factor; Reviewed; Region: PRK12527
640081005354	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081005355	DNA binding residues [nucleotide binding]
640081005356	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081005357	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
640081005358	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
640081005359	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
640081005360	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
640081005361	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
640081005362	RNA binding surface [nucleotide binding]; other site
640081005363	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
640081005364	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
640081005365	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
640081005366	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
640081005367	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081005368	N-terminal plug; other site
640081005369	ligand-binding site [chemical binding]; other site
640081005370	Hemin uptake protein hemP; Region: hemP; pfam10636
640081005371	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
640081005372	TolR protein; Region: tolR; TIGR02801
640081005373	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
640081005374	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
640081005375	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
640081005376	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
640081005377	dimer interface [polypeptide binding]; other site
640081005378	substrate binding site [chemical binding]; other site
640081005379	metal binding sites [ion binding]; metal-binding site
640081005380	NAD synthetase; Provisional; Region: PRK13981
640081005381	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
640081005382	multimer interface [polypeptide binding]; other site
640081005383	active site
640081005384	catalytic triad [active]
640081005385	protein interface 1 [polypeptide binding]; other site
640081005386	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
640081005387	homodimer interface [polypeptide binding]; other site
640081005388	NAD binding pocket [chemical binding]; other site
640081005389	ATP binding pocket [chemical binding]; other site
640081005390	Mg binding site [ion binding]; other site
640081005391	active-site loop [active]
640081005392	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
640081005393	Nitrogen regulatory protein P-II; Region: P-II; smart00938
640081005394	Smr domain; Region: Smr; pfam01713
640081005395	thioredoxin reductase; Provisional; Region: PRK10262
640081005396	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
640081005397	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
640081005398	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081005399	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
640081005400	ligand binding site [chemical binding]; other site
640081005401	flexible hinge region; other site
640081005402	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
640081005403	putative switch regulator; other site
640081005404	non-specific DNA interactions [nucleotide binding]; other site
640081005405	DNA binding site [nucleotide binding]
640081005406	sequence specific DNA binding site [nucleotide binding]; other site
640081005407	putative cAMP binding site [chemical binding]; other site
640081005408	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
640081005409	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
640081005410	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
640081005411	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
640081005412	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
640081005413	recombination factor protein RarA; Reviewed; Region: PRK13342
640081005414	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081005415	Walker A motif; other site
640081005416	ATP binding site [chemical binding]; other site
640081005417	Walker B motif; other site
640081005418	arginine finger; other site
640081005419	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
640081005420	GxxExxY protein; Region: GxxExxY; TIGR04256
640081005421	seryl-tRNA synthetase; Provisional; Region: PRK05431
640081005422	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
640081005423	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
640081005424	dimer interface [polypeptide binding]; other site
640081005425	active site
640081005426	motif 1; other site
640081005427	motif 2; other site
640081005428	motif 3; other site
640081005429	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
640081005430	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
640081005431	substrate binding pocket [chemical binding]; other site
640081005432	membrane-bound complex binding site; other site
640081005433	hinge residues; other site
640081005434	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
640081005435	N-acetyl-D-glucosamine binding site [chemical binding]; other site
640081005436	catalytic residue [active]
640081005437	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
640081005438	Protein of unknown function, DUF599; Region: DUF599; pfam04654
640081005439	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
640081005440	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
640081005441	active site
640081005442	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
640081005443	nudix motif; other site
640081005444	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
640081005445	flagellar motor protein MotA; Validated; Region: PRK09110
640081005446	flagellar motor protein MotB; Validated; Region: motB; PRK09041
640081005447	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
640081005448	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
640081005449	ligand binding site [chemical binding]; other site
640081005450	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081005451	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081005452	dimer interface [polypeptide binding]; other site
640081005453	putative CheW interface [polypeptide binding]; other site
640081005454	Response regulator receiver domain; Region: Response_reg; pfam00072
640081005455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005456	active site
640081005457	phosphorylation site [posttranslational modification]
640081005458	intermolecular recognition site; other site
640081005459	dimerization interface [polypeptide binding]; other site
640081005460	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
640081005461	putative binding surface; other site
640081005462	active site
640081005463	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
640081005464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081005465	ATP binding site [chemical binding]; other site
640081005466	Mg2+ binding site [ion binding]; other site
640081005467	G-X-G motif; other site
640081005468	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
640081005469	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
640081005470	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081005471	PAS domain; Region: PAS_9; pfam13426
640081005472	putative active site [active]
640081005473	heme pocket [chemical binding]; other site
640081005474	Tar ligand binding domain homologue; Region: TarH; pfam02203
640081005475	HAMP domain; Region: HAMP; pfam00672
640081005476	dimerization interface [polypeptide binding]; other site
640081005477	PAS domain; Region: PAS_9; pfam13426
640081005478	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081005479	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081005480	dimer interface [polypeptide binding]; other site
640081005481	putative CheW interface [polypeptide binding]; other site
640081005482	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
640081005483	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
640081005484	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
640081005485	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487
640081005486	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
640081005487	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005488	active site
640081005489	phosphorylation site [posttranslational modification]
640081005490	intermolecular recognition site; other site
640081005491	dimerization interface [polypeptide binding]; other site
640081005492	CheB methylesterase; Region: CheB_methylest; pfam01339
640081005493	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
640081005494	anti sigma factor interaction site; other site
640081005495	regulatory phosphorylation site [posttranslational modification]; other site
640081005496	Response regulator receiver domain; Region: Response_reg; pfam00072
640081005497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005498	active site
640081005499	phosphorylation site [posttranslational modification]
640081005500	intermolecular recognition site; other site
640081005501	dimerization interface [polypeptide binding]; other site
640081005502	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
640081005503	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
640081005504	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081005505	dimerization interface [polypeptide binding]; other site
640081005506	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081005507	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081005508	dimer interface [polypeptide binding]; other site
640081005509	putative CheW interface [polypeptide binding]; other site
640081005510	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
640081005511	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
640081005512	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005513	active site
640081005514	phosphorylation site [posttranslational modification]
640081005515	intermolecular recognition site; other site
640081005516	dimerization interface [polypeptide binding]; other site
640081005517	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
640081005518	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
640081005519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005520	active site
640081005521	phosphorylation site [posttranslational modification]
640081005522	intermolecular recognition site; other site
640081005523	dimerization interface [polypeptide binding]; other site
640081005524	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
640081005525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005526	active site
640081005527	phosphorylation site [posttranslational modification]
640081005528	intermolecular recognition site; other site
640081005529	dimerization interface [polypeptide binding]; other site
640081005530	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
640081005531	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
640081005532	putative binding surface; other site
640081005533	active site
640081005534	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
640081005535	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
640081005536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081005537	ATP binding site [chemical binding]; other site
640081005538	Mg2+ binding site [ion binding]; other site
640081005539	G-X-G motif; other site
640081005540	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
640081005541	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
640081005542	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
640081005543	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
640081005544	FHIPEP family; Region: FHIPEP; pfam00771
640081005545	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
640081005546	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
640081005547	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
640081005548	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
640081005549	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
640081005550	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081005551	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
640081005552	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081005553	DNA binding residues [nucleotide binding]
640081005554	flagellar motor protein; Reviewed; Region: motC; PRK09109
640081005555	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
640081005556	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
640081005557	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
640081005558	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
640081005559	ligand binding site [chemical binding]; other site
640081005560	FlgN protein; Region: FlgN; pfam05130
640081005561	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
640081005562	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
640081005563	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
640081005564	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
640081005565	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
640081005566	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
640081005567	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
640081005568	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
640081005569	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
640081005570	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
640081005571	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
640081005572	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
640081005573	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
640081005574	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
640081005575	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
640081005576	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
640081005577	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
640081005578	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
640081005579	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
640081005580	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
640081005581	Flagellar L-ring protein; Region: FlgH; pfam02107
640081005582	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
640081005583	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
640081005584	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
640081005585	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
640081005586	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
640081005587	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
640081005588	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
640081005589	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
640081005590	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
640081005591	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
640081005592	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
640081005593	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
640081005594	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
640081005595	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
640081005596	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
640081005597	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
640081005598	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
640081005599	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
640081005600	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
640081005601	Flagellar FliJ protein; Region: FliJ; pfam02050
640081005602	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
640081005603	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
640081005604	Walker A motif/ATP binding site; other site
640081005605	Walker B motif; other site
640081005606	flagellar assembly protein H; Validated; Region: fliH; PRK05687
640081005607	Flagellar assembly protein FliH; Region: FliH; pfam02108
640081005608	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
640081005609	FliG C-terminal domain; Region: FliG_C; pfam01706
640081005610	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
640081005611	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
640081005612	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
640081005613	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
640081005614	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
640081005615	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081005616	dimer interface [polypeptide binding]; other site
640081005617	phosphorylation site [posttranslational modification]
640081005618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081005619	ATP binding site [chemical binding]; other site
640081005620	Mg2+ binding site [ion binding]; other site
640081005621	G-X-G motif; other site
640081005622	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
640081005623	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005624	active site
640081005625	phosphorylation site [posttranslational modification]
640081005626	intermolecular recognition site; other site
640081005627	dimerization interface [polypeptide binding]; other site
640081005628	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081005629	Walker A motif; other site
640081005630	ATP binding site [chemical binding]; other site
640081005631	Walker B motif; other site
640081005632	arginine finger; other site
640081005633	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081005634	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
640081005635	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
640081005636	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081005637	binding surface
640081005638	TPR motif; other site
640081005639	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081005640	binding surface
640081005641	TPR motif; other site
640081005642	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
640081005643	Methyltransferase domain; Region: Methyltransf_11; pfam08241
640081005644	Methyltransferase domain; Region: Methyltransf_11; pfam08241
640081005645	S-adenosylmethionine binding site [chemical binding]; other site
640081005646	FkbH-like domain; Region: FkbH; TIGR01686
640081005647	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
640081005648	active site
640081005649	motif I; other site
640081005650	motif II; other site
640081005651	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
640081005652	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
640081005653	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669
640081005654	active site
640081005655	Methyltransferase domain; Region: Methyltransf_23; pfam13489
640081005656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081005657	S-adenosylmethionine binding site [chemical binding]; other site
640081005658	WxcM-like, C-terminal; Region: FdtA; pfam05523
640081005659	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
640081005660	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
640081005661	inhibitor-cofactor binding pocket; inhibition site
640081005662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081005663	catalytic residue [active]
640081005664	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
640081005665	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
640081005666	Walker A/P-loop; other site
640081005667	ATP binding site [chemical binding]; other site
640081005668	Q-loop/lid; other site
640081005669	ABC transporter signature motif; other site
640081005670	Walker B; other site
640081005671	D-loop; other site
640081005672	H-loop/switch region; other site
640081005673	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
640081005674	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
640081005675	Walker A/P-loop; other site
640081005676	ATP binding site [chemical binding]; other site
640081005677	Q-loop/lid; other site
640081005678	ABC transporter signature motif; other site
640081005679	Walker B; other site
640081005680	D-loop; other site
640081005681	H-loop/switch region; other site
640081005682	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
640081005683	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
640081005684	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081005685	Flagellar regulator YcgR; Region: YcgR; pfam07317
640081005686	PilZ domain; Region: PilZ; pfam07238
640081005687	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
640081005688	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
640081005689	Flagellar protein FliT; Region: FliT; pfam05400
640081005690	flagellar protein FliS; Validated; Region: fliS; PRK05685
640081005691	flagellar capping protein; Reviewed; Region: fliD; PRK08032
640081005692	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
640081005693	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
640081005694	FlaG protein; Region: FlaG; pfam03646
640081005695	flagellin; Provisional; Region: PRK12802
640081005696	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
640081005697	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
640081005698	flagellin; Provisional; Region: PRK12802
640081005699	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
640081005700	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
640081005701	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081005702	binding surface
640081005703	TPR motif; other site
640081005704	Tetratricopeptide repeat; Region: TPR_12; pfam13424
640081005705	Tetratricopeptide repeat; Region: TPR_12; pfam13424
640081005706	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081005707	binding surface
640081005708	TPR motif; other site
640081005709	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
640081005710	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081005711	TPR motif; other site
640081005712	Tetratricopeptide repeat; Region: TPR_16; pfam13432
640081005713	binding surface
640081005714	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081005715	binding surface
640081005716	TPR motif; other site
640081005717	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081005718	binding surface
640081005719	TPR motif; other site
640081005720	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081005721	binding surface
640081005722	TPR motif; other site
640081005723	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
640081005724	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
640081005725	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
640081005726	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
640081005727	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
640081005728	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
640081005729	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
640081005730	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
640081005731	active site
640081005732	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
640081005733	active site
640081005734	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
640081005735	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
640081005736	Probable Catalytic site; other site
640081005737	metal-binding site
640081005738	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
640081005739	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
640081005740	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
640081005741	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081005742	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081005743	metal binding site [ion binding]; metal-binding site
640081005744	active site
640081005745	I-site; other site
640081005746	integrase; Provisional; Region: PRK09692
640081005747	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
640081005748	active site
640081005749	Int/Topo IB signature motif; other site
640081005750	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
640081005751	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
640081005752	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
640081005753	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
640081005754	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
640081005755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081005756	Walker A motif; other site
640081005757	ATP binding site [chemical binding]; other site
640081005758	Walker B motif; other site
640081005759	arginine finger; other site
640081005760	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
640081005761	Transcriptional regulator [Transcription]; Region: IclR; COG1414
640081005762	Bacterial transcriptional regulator; Region: IclR; pfam01614
640081005763	ParA-like protein; Provisional; Region: PHA02518
640081005764	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
640081005765	P-loop; other site
640081005766	Magnesium ion binding site [ion binding]; other site
640081005767	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969
640081005768	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081005769	Walker A motif; other site
640081005770	ATP binding site [chemical binding]; other site
640081005771	Walker B motif; other site
640081005772	arginine finger; other site
640081005773	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
640081005774	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
640081005775	hypothetical protein; Validated; Region: PRK00153
640081005776	recombination protein RecR; Reviewed; Region: recR; PRK00076
640081005777	RecR protein; Region: RecR; pfam02132
640081005778	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
640081005779	putative active site [active]
640081005780	putative metal-binding site [ion binding]; other site
640081005781	tetramer interface [polypeptide binding]; other site
640081005782	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
640081005783	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
640081005784	[2Fe-2S] cluster binding site [ion binding]; other site
640081005785	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
640081005786	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
640081005787	Qi binding site; other site
640081005788	intrachain domain interface; other site
640081005789	interchain domain interface [polypeptide binding]; other site
640081005790	heme bH binding site [chemical binding]; other site
640081005791	heme bL binding site [chemical binding]; other site
640081005792	Qo binding site; other site
640081005793	interchain domain interface [polypeptide binding]; other site
640081005794	intrachain domain interface; other site
640081005795	Qi binding site; other site
640081005796	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
640081005797	Qo binding site; other site
640081005798	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
640081005799	stringent starvation protein A; Provisional; Region: sspA; PRK09481
640081005800	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
640081005801	C-terminal domain interface [polypeptide binding]; other site
640081005802	putative GSH binding site (G-site) [chemical binding]; other site
640081005803	dimer interface [polypeptide binding]; other site
640081005804	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
640081005805	dimer interface [polypeptide binding]; other site
640081005806	N-terminal domain interface [polypeptide binding]; other site
640081005807	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
640081005808	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
640081005809	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
640081005810	[4Fe-4S] binding site [ion binding]; other site
640081005811	molybdopterin cofactor binding site; other site
640081005812	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
640081005813	molybdopterin cofactor binding site; other site
640081005814	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
640081005815	glycosyl transferase family protein; Provisional; Region: PRK08136
640081005816	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
640081005817	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
640081005818	active site 1 [active]
640081005819	dimer interface [polypeptide binding]; other site
640081005820	hexamer interface [polypeptide binding]; other site
640081005821	active site 2 [active]
640081005822	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
640081005823	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
640081005824	putative ligand binding site [chemical binding]; other site
640081005825	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
640081005826	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
640081005827	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
640081005828	PAS domain S-box; Region: sensory_box; TIGR00229
640081005829	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081005830	putative active site [active]
640081005831	heme pocket [chemical binding]; other site
640081005832	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081005833	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081005834	metal binding site [ion binding]; metal-binding site
640081005835	active site
640081005836	I-site; other site
640081005837	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
640081005838	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
640081005839	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
640081005840	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
640081005841	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
640081005842	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
640081005843	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
640081005844	[2Fe-2S] cluster binding site [ion binding]; other site
640081005845	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
640081005846	putative active site [active]
640081005847	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
640081005848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
640081005849	active site
640081005850	phosphorylation site [posttranslational modification]
640081005851	intermolecular recognition site; other site
640081005852	dimerization interface [polypeptide binding]; other site
640081005853	ANTAR domain; Region: ANTAR; pfam03861
640081005854	Yip1 domain; Region: Yip1; cl17815
640081005855	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
640081005856	NMT1-like family; Region: NMT1_2; pfam13379
640081005857	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
640081005858	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081005859	dimer interface [polypeptide binding]; other site
640081005860	conserved gate region; other site
640081005861	putative PBP binding loops; other site
640081005862	ABC-ATPase subunit interface; other site
640081005863	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
640081005864	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
640081005865	Walker A/P-loop; other site
640081005866	ATP binding site [chemical binding]; other site
640081005867	Q-loop/lid; other site
640081005868	ABC transporter signature motif; other site
640081005869	Walker B; other site
640081005870	D-loop; other site
640081005871	H-loop/switch region; other site
640081005872	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
640081005873	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
640081005874	putative ADP-binding pocket [chemical binding]; other site
640081005875	GAF domain; Region: GAF; pfam01590
640081005876	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081005877	Zn2+ binding site [ion binding]; other site
640081005878	Mg2+ binding site [ion binding]; other site
640081005879	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
640081005880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
640081005881	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
640081005882	non-specific DNA binding site [nucleotide binding]; other site
640081005883	salt bridge; other site
640081005884	sequence-specific DNA binding site [nucleotide binding]; other site
640081005885	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
640081005886	Phosphate transporter family; Region: PHO4; pfam01384
640081005887	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248
640081005888	substrate binding site [chemical binding]; other site
640081005889	dimerization interface [polypeptide binding]; other site
640081005890	active site
640081005891	calcium binding site [ion binding]; other site
640081005892	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
640081005893	Coenzyme A binding pocket [chemical binding]; other site
640081005894	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
640081005895	Sodium Bile acid symporter family; Region: SBF; cl17470
640081005896	Low molecular weight phosphatase family; Region: LMWPc; cd00115
640081005897	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
640081005898	active site
640081005899	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
640081005900	dimerization interface [polypeptide binding]; other site
640081005901	putative DNA binding site [nucleotide binding]; other site
640081005902	putative Zn2+ binding site [ion binding]; other site
640081005903	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081005904	dimerization interface [polypeptide binding]; other site
640081005905	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081005906	dimer interface [polypeptide binding]; other site
640081005907	phosphorylation site [posttranslational modification]
640081005908	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081005909	ATP binding site [chemical binding]; other site
640081005910	Mg2+ binding site [ion binding]; other site
640081005911	G-X-G motif; other site
640081005912	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
640081005913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005914	active site
640081005915	phosphorylation site [posttranslational modification]
640081005916	intermolecular recognition site; other site
640081005917	dimerization interface [polypeptide binding]; other site
640081005918	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081005919	DNA binding site [nucleotide binding]
640081005920	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
640081005921	dimer interface [polypeptide binding]; other site
640081005922	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
640081005923	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
640081005924	active site 1 [active]
640081005925	dimer interface [polypeptide binding]; other site
640081005926	hexamer interface [polypeptide binding]; other site
640081005927	active site 2 [active]
640081005928	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
640081005929	EamA-like transporter family; Region: EamA; pfam00892
640081005930	EamA-like transporter family; Region: EamA; pfam00892
640081005931	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081005932	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081005933	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
640081005934	putative dimerization interface [polypeptide binding]; other site
640081005935	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
640081005936	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081005937	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081005938	dimer interface [polypeptide binding]; other site
640081005939	putative CheW interface [polypeptide binding]; other site
640081005940	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
640081005941	putative binding surface; other site
640081005942	active site
640081005943	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
640081005944	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005945	active site
640081005946	phosphorylation site [posttranslational modification]
640081005947	intermolecular recognition site; other site
640081005948	dimerization interface [polypeptide binding]; other site
640081005949	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
640081005950	DNA binding residues [nucleotide binding]
640081005951	dimerization interface [polypeptide binding]; other site
640081005952	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
640081005953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005954	active site
640081005955	phosphorylation site [posttranslational modification]
640081005956	intermolecular recognition site; other site
640081005957	dimerization interface [polypeptide binding]; other site
640081005958	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081005959	Zn2+ binding site [ion binding]; other site
640081005960	Mg2+ binding site [ion binding]; other site
640081005961	Uncharacterized conserved protein [Function unknown]; Region: COG3287
640081005962	FIST N domain; Region: FIST; pfam08495
640081005963	FIST C domain; Region: FIST_C; pfam10442
640081005964	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081005965	PAS domain; Region: PAS_9; pfam13426
640081005966	putative active site [active]
640081005967	heme pocket [chemical binding]; other site
640081005968	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
640081005969	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081005970	putative active site [active]
640081005971	heme pocket [chemical binding]; other site
640081005972	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081005973	dimer interface [polypeptide binding]; other site
640081005974	phosphorylation site [posttranslational modification]
640081005975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081005976	ATP binding site [chemical binding]; other site
640081005977	Mg2+ binding site [ion binding]; other site
640081005978	G-X-G motif; other site
640081005979	Response regulator receiver domain; Region: Response_reg; pfam00072
640081005980	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005981	active site
640081005982	phosphorylation site [posttranslational modification]
640081005983	intermolecular recognition site; other site
640081005984	dimerization interface [polypeptide binding]; other site
640081005985	Hpt domain; Region: Hpt; pfam01627
640081005986	Response regulator receiver domain; Region: Response_reg; pfam00072
640081005987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081005988	active site
640081005989	phosphorylation site [posttranslational modification]
640081005990	intermolecular recognition site; other site
640081005991	dimerization interface [polypeptide binding]; other site
640081005992	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081005993	dimer interface [polypeptide binding]; other site
640081005994	phosphorylation site [posttranslational modification]
640081005995	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081005996	ATP binding site [chemical binding]; other site
640081005997	Mg2+ binding site [ion binding]; other site
640081005998	G-X-G motif; other site
640081005999	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
640081006000	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
640081006001	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081006002	Zn2+ binding site [ion binding]; other site
640081006003	Mg2+ binding site [ion binding]; other site
640081006004	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
640081006005	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
640081006006	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
640081006007	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
640081006008	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
640081006009	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081006010	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
640081006011	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
640081006012	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
640081006013	hypothetical protein; Provisional; Region: PRK02237
640081006014	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
640081006015	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
640081006016	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
640081006017	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
640081006018	FMN binding site [chemical binding]; other site
640081006019	active site
640081006020	substrate binding site [chemical binding]; other site
640081006021	catalytic residue [active]
640081006022	EamA-like transporter family; Region: EamA; pfam00892
640081006023	EamA-like transporter family; Region: EamA; pfam00892
640081006024	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
640081006025	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
640081006026	HAMP domain; Region: HAMP; pfam00672
640081006027	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081006028	dimer interface [polypeptide binding]; other site
640081006029	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
640081006030	putative CheW interface [polypeptide binding]; other site
640081006031	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
640081006032	putative deacylase active site [active]
640081006033	ABC transporter ATPase component; Reviewed; Region: PRK11147
640081006034	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081006035	Walker A/P-loop; other site
640081006036	ATP binding site [chemical binding]; other site
640081006037	Q-loop/lid; other site
640081006038	ABC transporter signature motif; other site
640081006039	Walker B; other site
640081006040	D-loop; other site
640081006041	H-loop/switch region; other site
640081006042	ABC transporter; Region: ABC_tran_2; pfam12848
640081006043	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
640081006044	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081006045	dimer interface [polypeptide binding]; other site
640081006046	phosphorylation site [posttranslational modification]
640081006047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081006048	ATP binding site [chemical binding]; other site
640081006049	G-X-G motif; other site
640081006050	Response regulator receiver domain; Region: Response_reg; pfam00072
640081006051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081006052	active site
640081006053	phosphorylation site [posttranslational modification]
640081006054	intermolecular recognition site; other site
640081006055	dimerization interface [polypeptide binding]; other site
640081006056	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
640081006057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081006058	active site
640081006059	phosphorylation site [posttranslational modification]
640081006060	intermolecular recognition site; other site
640081006061	dimerization interface [polypeptide binding]; other site
640081006062	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081006063	Zn2+ binding site [ion binding]; other site
640081006064	Mg2+ binding site [ion binding]; other site
640081006065	PAS domain; Region: PAS_9; pfam13426
640081006066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081006067	putative active site [active]
640081006068	heme pocket [chemical binding]; other site
640081006069	PAS domain S-box; Region: sensory_box; TIGR00229
640081006070	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081006071	putative active site [active]
640081006072	heme pocket [chemical binding]; other site
640081006073	PAS domain; Region: PAS; smart00091
640081006074	PAS fold; Region: PAS_4; pfam08448
640081006075	putative active site [active]
640081006076	heme pocket [chemical binding]; other site
640081006077	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081006078	dimer interface [polypeptide binding]; other site
640081006079	phosphorylation site [posttranslational modification]
640081006080	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081006081	ATP binding site [chemical binding]; other site
640081006082	G-X-G motif; other site
640081006083	HDOD domain; Region: HDOD; pfam08668
640081006084	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081006085	Zn2+ binding site [ion binding]; other site
640081006086	Mg2+ binding site [ion binding]; other site
640081006087	PAS domain S-box; Region: sensory_box; TIGR00229
640081006088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081006089	putative active site [active]
640081006090	heme pocket [chemical binding]; other site
640081006091	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081006092	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081006093	metal binding site [ion binding]; metal-binding site
640081006094	active site
640081006095	I-site; other site
640081006096	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081006097	Response regulator receiver domain; Region: Response_reg; pfam00072
640081006098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081006099	active site
640081006100	phosphorylation site [posttranslational modification]
640081006101	intermolecular recognition site; other site
640081006102	dimerization interface [polypeptide binding]; other site
640081006103	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
640081006104	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
640081006105	putative active site pocket [active]
640081006106	metal binding site [ion binding]; metal-binding site
640081006107	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081006108	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081006109	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
640081006110	putative effector binding pocket; other site
640081006111	putative dimerization interface [polypeptide binding]; other site
640081006112	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
640081006113	E3 Ubiquitin ligase; Region: GIDE; pfam12483
640081006114	Ca2+ binding site [ion binding]; other site
640081006115	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
640081006116	LemA family; Region: LemA; cl00742
640081006117	Major Facilitator Superfamily; Region: MFS_1; pfam07690
640081006118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
640081006119	putative substrate translocation pore; other site
640081006120	HDOD domain; Region: HDOD; pfam08668
640081006121	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
640081006122	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
640081006123	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
640081006124	peroxiredoxin; Region: AhpC; TIGR03137
640081006125	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
640081006126	dimer interface [polypeptide binding]; other site
640081006127	decamer (pentamer of dimers) interface [polypeptide binding]; other site
640081006128	catalytic triad [active]
640081006129	peroxidatic and resolving cysteines [active]
640081006130	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
640081006131	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
640081006132	catalytic residue [active]
640081006133	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
640081006134	catalytic residues [active]
640081006135	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
640081006136	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
640081006137	B12 binding site [chemical binding]; other site
640081006138	Radical SAM superfamily; Region: Radical_SAM; pfam04055
640081006139	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
640081006140	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081006141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081006142	homodimer interface [polypeptide binding]; other site
640081006143	catalytic residue [active]
640081006144	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
640081006145	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
640081006146	substrate binding pocket [chemical binding]; other site
640081006147	membrane-bound complex binding site; other site
640081006148	hinge residues; other site
640081006149	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
640081006150	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081006151	putative active site [active]
640081006152	heme pocket [chemical binding]; other site
640081006153	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081006154	dimer interface [polypeptide binding]; other site
640081006155	phosphorylation site [posttranslational modification]
640081006156	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081006157	ATP binding site [chemical binding]; other site
640081006158	Mg2+ binding site [ion binding]; other site
640081006159	G-X-G motif; other site
640081006160	Response regulator receiver domain; Region: Response_reg; pfam00072
640081006161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081006162	active site
640081006163	phosphorylation site [posttranslational modification]
640081006164	intermolecular recognition site; other site
640081006165	dimerization interface [polypeptide binding]; other site
640081006166	Protein of unknown function (DUF554); Region: DUF554; pfam04474
640081006167	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081006168	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081006169	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
640081006170	dimerization interface [polypeptide binding]; other site
640081006171	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464
640081006172	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081006173	FeS/SAM binding site; other site
640081006174	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
640081006175	ParB-like nuclease domain; Region: ParBc; pfam02195
640081006176	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
640081006177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081006178	active site
640081006179	phosphorylation site [posttranslational modification]
640081006180	intermolecular recognition site; other site
640081006181	dimerization interface [polypeptide binding]; other site
640081006182	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081006183	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081006184	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
640081006185	dimer interface [polypeptide binding]; other site
640081006186	phosphorylation site [posttranslational modification]
640081006187	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081006188	ATP binding site [chemical binding]; other site
640081006189	Mg2+ binding site [ion binding]; other site
640081006190	G-X-G motif; other site
640081006191	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
640081006192	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
640081006193	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
640081006194	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
640081006195	YcaO domain protein; Region: TIGR03549
640081006196	OsmC-like protein; Region: OsmC; pfam02566
640081006197	YcaO-like family; Region: YcaO; pfam02624
640081006198	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
640081006199	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
640081006200	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
640081006201	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
640081006202	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
640081006203	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081006204	N-terminal plug; other site
640081006205	ligand-binding site [chemical binding]; other site
640081006206	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
640081006207	dimer interface [polypeptide binding]; other site
640081006208	putative radical transfer pathway; other site
640081006209	diiron center [ion binding]; other site
640081006210	tyrosyl radical; other site
640081006211	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
640081006212	ATP cone domain; Region: ATP-cone; pfam03477
640081006213	Class I ribonucleotide reductase; Region: RNR_I; cd01679
640081006214	active site
640081006215	dimer interface [polypeptide binding]; other site
640081006216	catalytic residues [active]
640081006217	effector binding site; other site
640081006218	R2 peptide binding site; other site
640081006219	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
640081006220	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
640081006221	PYR/PP interface [polypeptide binding]; other site
640081006222	dimer interface [polypeptide binding]; other site
640081006223	TPP binding site [chemical binding]; other site
640081006224	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
640081006225	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
640081006226	TPP-binding site [chemical binding]; other site
640081006227	dimer interface [polypeptide binding]; other site
640081006228	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
640081006229	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
640081006230	putative valine binding site [chemical binding]; other site
640081006231	dimer interface [polypeptide binding]; other site
640081006232	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
640081006233	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
640081006234	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
640081006235	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
640081006236	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
640081006237	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
640081006238	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
640081006239	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
640081006240	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
640081006241	phosphoglycolate phosphatase; Provisional; Region: PRK13222
640081006242	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
640081006243	motif II; other site
640081006244	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
640081006245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081006246	S-adenosylmethionine binding site [chemical binding]; other site
640081006247	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
640081006248	ligand binding site [chemical binding]; other site
640081006249	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
640081006250	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
640081006251	active site
640081006252	putative substrate binding pocket [chemical binding]; other site
640081006253	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
640081006254	ligand binding site [chemical binding]; other site
640081006255	DNA gyrase subunit A; Validated; Region: PRK05560
640081006256	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
640081006257	CAP-like domain; other site
640081006258	active site
640081006259	primary dimer interface [polypeptide binding]; other site
640081006260	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
640081006261	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
640081006262	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
640081006263	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
640081006264	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
640081006265	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
640081006266	homodimer interface [polypeptide binding]; other site
640081006267	substrate-cofactor binding pocket; other site
640081006268	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081006269	catalytic residue [active]
640081006270	Chorismate mutase type II; Region: CM_2; cl00693
640081006271	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
640081006272	Prephenate dehydratase; Region: PDT; pfam00800
640081006273	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
640081006274	putative L-Phe binding site [chemical binding]; other site
640081006275	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
640081006276	prephenate dehydrogenase; Validated; Region: PRK08507
640081006277	bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase; Provisional; Region: PRK11860
640081006278	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
640081006279	hinge; other site
640081006280	active site
640081006281	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
640081006282	CMP-binding site; other site
640081006283	The sites determining sugar specificity; other site
640081006284	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
640081006285	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
640081006286	RNA binding site [nucleotide binding]; other site
640081006287	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
640081006288	RNA binding site [nucleotide binding]; other site
640081006289	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
640081006290	RNA binding site [nucleotide binding]; other site
640081006291	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
640081006292	RNA binding site [nucleotide binding]; other site
640081006293	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
640081006294	RNA binding site [nucleotide binding]; other site
640081006295	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
640081006296	RNA binding site [nucleotide binding]; other site
640081006297	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
640081006298	IHF dimer interface [polypeptide binding]; other site
640081006299	IHF - DNA interface [nucleotide binding]; other site
640081006300	tetratricopeptide repeat protein; Provisional; Region: PRK11788
640081006301	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081006302	binding surface
640081006303	TPR motif; other site
640081006304	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
640081006305	binding surface
640081006306	TPR motif; other site
640081006307	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
640081006308	Domain of unknown function (DUF373); Region: DUF373; cl12079
640081006309	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
640081006310	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
640081006311	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
640081006312	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
640081006313	NAD binding site [chemical binding]; other site
640081006314	substrate binding site [chemical binding]; other site
640081006315	homodimer interface [polypeptide binding]; other site
640081006316	active site
640081006317	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
640081006318	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
640081006319	NADP binding site [chemical binding]; other site
640081006320	active site
640081006321	putative substrate binding site [chemical binding]; other site
640081006322	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
640081006323	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
640081006324	substrate binding site; other site
640081006325	tetramer interface; other site
640081006326	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
640081006327	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
640081006328	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
640081006329	putative ribose interaction site [chemical binding]; other site
640081006330	putative ADP binding site [chemical binding]; other site
640081006331	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
640081006332	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
640081006333	NADP binding site [chemical binding]; other site
640081006334	homopentamer interface [polypeptide binding]; other site
640081006335	substrate binding site [chemical binding]; other site
640081006336	active site
640081006337	cysteine synthase B; Region: cysM; TIGR01138
640081006338	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
640081006339	dimer interface [polypeptide binding]; other site
640081006340	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081006341	catalytic residue [active]
640081006342	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
640081006343	active site
640081006344	catalytic site [active]
640081006345	substrate binding site [chemical binding]; other site
640081006346	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
640081006347	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
640081006348	active site residue [active]
640081006349	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
640081006350	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
640081006351	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
640081006352	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
640081006353	active site
640081006354	dimer interface [polypeptide binding]; other site
640081006355	motif 1; other site
640081006356	motif 2; other site
640081006357	motif 3; other site
640081006358	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
640081006359	anticodon binding site; other site
640081006360	translation initiation factor IF-3; Region: infC; TIGR00168
640081006361	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
640081006362	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
640081006363	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
640081006364	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
640081006365	23S rRNA binding site [nucleotide binding]; other site
640081006366	L21 binding site [polypeptide binding]; other site
640081006367	L13 binding site [polypeptide binding]; other site
640081006368	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
640081006369	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
640081006370	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
640081006371	dimer interface [polypeptide binding]; other site
640081006372	motif 1; other site
640081006373	active site
640081006374	motif 2; other site
640081006375	motif 3; other site
640081006376	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
640081006377	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
640081006378	putative tRNA-binding site [nucleotide binding]; other site
640081006379	B3/4 domain; Region: B3_4; pfam03483
640081006380	tRNA synthetase B5 domain; Region: B5; smart00874
640081006381	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
640081006382	dimer interface [polypeptide binding]; other site
640081006383	motif 1; other site
640081006384	motif 3; other site
640081006385	motif 2; other site
640081006386	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
640081006387	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
640081006388	IHF - DNA interface [nucleotide binding]; other site
640081006389	IHF dimer interface [polypeptide binding]; other site
640081006390	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
640081006391	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
640081006392	DNA binding residues [nucleotide binding]
640081006393	H-NS histone family; Region: Histone_HNS; pfam00816
640081006394	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
640081006395	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
640081006396	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
640081006397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081006398	S-adenosylmethionine binding site [chemical binding]; other site
640081006399	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
640081006400	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
640081006401	Peptidase family M23; Region: Peptidase_M23; pfam01551
640081006402	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
640081006403	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
640081006404	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081006405	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
640081006406	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081006407	DNA binding residues [nucleotide binding]
640081006408	Transglycosylase SLT domain; Region: SLT_2; pfam13406
640081006409	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
640081006410	N-acetyl-D-glucosamine binding site [chemical binding]; other site
640081006411	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
640081006412	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
640081006413	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
640081006414	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
640081006415	Protein of unknown function DUF58; Region: DUF58; pfam01882
640081006416	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081006417	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
640081006418	Walker A motif; other site
640081006419	ATP binding site [chemical binding]; other site
640081006420	Walker B motif; other site
640081006421	arginine finger; other site
640081006422	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
640081006423	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
640081006424	putative active site [active]
640081006425	Zn binding site [ion binding]; other site
640081006426	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
640081006427	dihydrodipicolinate synthase; Region: dapA; TIGR00674
640081006428	dimer interface [polypeptide binding]; other site
640081006429	active site
640081006430	catalytic residue [active]
640081006431	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
640081006432	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
640081006433	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
640081006434	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
640081006435	TRAM domain; Region: TRAM; pfam01938
640081006436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
640081006437	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
640081006438	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
640081006439	CysD dimerization site [polypeptide binding]; other site
640081006440	G1 box; other site
640081006441	putative GEF interaction site [polypeptide binding]; other site
640081006442	GTP/Mg2+ binding site [chemical binding]; other site
640081006443	Switch I region; other site
640081006444	G2 box; other site
640081006445	G3 box; other site
640081006446	Switch II region; other site
640081006447	G4 box; other site
640081006448	G5 box; other site
640081006449	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
640081006450	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
640081006451	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
640081006452	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
640081006453	Active Sites [active]
640081006454	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
640081006455	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
640081006456	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
640081006457	Active Sites [active]
640081006458	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
640081006459	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
640081006460	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
640081006461	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
640081006462	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
640081006463	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
640081006464	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
640081006465	putative DNA binding site [nucleotide binding]; other site
640081006466	putative Zn2+ binding site [ion binding]; other site
640081006467	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
640081006468	substrate binding site [chemical binding]; other site
640081006469	dimerization interface [polypeptide binding]; other site
640081006470	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
640081006471	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
640081006472	generic binding surface I; other site
640081006473	generic binding surface II; other site
640081006474	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
640081006475	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
640081006476	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
640081006477	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
640081006478	replicative DNA helicase; Region: DnaB; TIGR00665
640081006479	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
640081006480	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
640081006481	Walker A motif; other site
640081006482	ATP binding site [chemical binding]; other site
640081006483	Walker B motif; other site
640081006484	DNA binding loops [nucleotide binding]
640081006485	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
640081006486	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
640081006487	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
640081006488	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
640081006489	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
640081006490	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
640081006491	putative active site [active]
640081006492	PhoH-like protein; Region: PhoH; pfam02562
640081006493	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
640081006494	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
640081006495	catalytic triad [active]
640081006496	glutamate racemase; Provisional; Region: PRK00865
640081006497	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
640081006498	homotrimer interaction site [polypeptide binding]; other site
640081006499	putative active site [active]
640081006500	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
640081006501	Fumarase C-terminus; Region: Fumerase_C; pfam05683
640081006502	hypothetical protein; Provisional; Region: PRK05208
640081006503	acetyl-CoA synthetase; Provisional; Region: PRK00174
640081006504	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
640081006505	active site
640081006506	CoA binding site [chemical binding]; other site
640081006507	acyl-activating enzyme (AAE) consensus motif; other site
640081006508	AMP binding site [chemical binding]; other site
640081006509	acetate binding site [chemical binding]; other site
640081006510	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
640081006511	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081006512	ligand binding site [chemical binding]; other site
640081006513	flexible hinge region; other site
640081006514	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
640081006515	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
640081006516	metal binding triad; other site
640081006517	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
640081006518	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
640081006519	active site
640081006520	catalytic site [active]
640081006521	substrate binding site [chemical binding]; other site
640081006522	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
640081006523	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
640081006524	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
640081006525	TPR repeat; Region: TPR_11; pfam13414
640081006526	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081006527	binding surface
640081006528	TPR motif; other site
640081006529	Staphylococcal nuclease homologues; Region: SNc; smart00318
640081006530	Catalytic site; other site
640081006531	Staphylococcal nuclease homologue; Region: SNase; pfam00565
640081006532	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081006533	ABC transporter signature motif; other site
640081006534	Walker B; other site
640081006535	D-loop; other site
640081006536	H-loop/switch region; other site
640081006537	Peptidase U49; Region: Peptidase_U49; pfam10463
640081006538	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
640081006539	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081006540	Walker A motif; other site
640081006541	ATP binding site [chemical binding]; other site
640081006542	Walker B motif; other site
640081006543	arginine finger; other site
640081006544	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
640081006545	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
640081006546	Integrase core domain; Region: rve; pfam00665
640081006547	CHAT domain; Region: CHAT; cl17868
640081006548	TniQ; Region: TniQ; pfam06527
640081006549	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081006550	AAA domain; Region: AAA_22; pfam13401
640081006551	Walker A motif; other site
640081006552	ATP binding site [chemical binding]; other site
640081006553	Walker B motif; other site
640081006554	arginine finger; other site
640081006555	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
640081006556	Integrase core domain; Region: rve; pfam00665
640081006557	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
640081006558	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
640081006559	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081006560	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081006561	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
640081006562	putative effector binding pocket; other site
640081006563	putative dimerization interface [polypeptide binding]; other site
640081006564	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
640081006565	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
640081006566	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
640081006567	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
640081006568	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081006569	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
640081006570	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
640081006571	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
640081006572	GIY-YIG motif/motif A; other site
640081006573	putative active site [active]
640081006574	putative metal binding site [ion binding]; other site
640081006575	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
640081006576	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
640081006577	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
640081006578	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
640081006579	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
640081006580	homodimer interface [polypeptide binding]; other site
640081006581	substrate-cofactor binding pocket; other site
640081006582	catalytic residue [active]
640081006583	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
640081006584	active site
640081006585	PAS fold; Region: PAS_4; pfam08448
640081006586	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081006587	putative active site [active]
640081006588	heme pocket [chemical binding]; other site
640081006589	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081006590	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081006591	metal binding site [ion binding]; metal-binding site
640081006592	active site
640081006593	I-site; other site
640081006594	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081006595	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
640081006596	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081006597	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
640081006598	dimerization interface [polypeptide binding]; other site
640081006599	substrate binding pocket [chemical binding]; other site
640081006600	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
640081006601	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
640081006602	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
640081006603	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
640081006604	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081006605	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
640081006606	dimerization interface [polypeptide binding]; other site
640081006607	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
640081006608	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
640081006609	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
640081006610	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
640081006611	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
640081006612	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
640081006613	homodimer interface [polypeptide binding]; other site
640081006614	substrate-cofactor binding pocket; other site
640081006615	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081006616	catalytic residue [active]
640081006617	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
640081006618	enoyl-CoA hydratase; Validated; Region: PRK08139
640081006619	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
640081006620	substrate binding site [chemical binding]; other site
640081006621	oxyanion hole (OAH) forming residues; other site
640081006622	trimer interface [polypeptide binding]; other site
640081006623	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
640081006624	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
640081006625	homodimer interface [polypeptide binding]; other site
640081006626	substrate-cofactor binding pocket; other site
640081006627	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081006628	catalytic residue [active]
640081006629	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
640081006630	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
640081006631	dimer interface [polypeptide binding]; other site
640081006632	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081006633	catalytic residue [active]
640081006634	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
640081006635	FOG: CBS domain [General function prediction only]; Region: COG0517
640081006636	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
640081006637	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
640081006638	active site residue [active]
640081006639	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
640081006640	Response regulator receiver domain; Region: Response_reg; pfam00072
640081006641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081006642	active site
640081006643	phosphorylation site [posttranslational modification]
640081006644	intermolecular recognition site; other site
640081006645	dimerization interface [polypeptide binding]; other site
640081006646	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081006647	PAS domain; Region: PAS_9; pfam13426
640081006648	putative active site [active]
640081006649	heme pocket [chemical binding]; other site
640081006650	PAS domain S-box; Region: sensory_box; TIGR00229
640081006651	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081006652	putative active site [active]
640081006653	heme pocket [chemical binding]; other site
640081006654	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081006655	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081006656	metal binding site [ion binding]; metal-binding site
640081006657	active site
640081006658	I-site; other site
640081006659	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
640081006660	Chromate transporter; Region: Chromate_transp; pfam02417
640081006661	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
640081006662	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
640081006663	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
640081006664	ABC transporter; Region: ABC_tran_2; pfam12848
640081006665	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
640081006666	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
640081006667	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
640081006668	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
640081006669	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
640081006670	active site
640081006671	Methyltransferase domain; Region: Methyltransf_23; pfam13489
640081006672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081006673	S-adenosylmethionine binding site [chemical binding]; other site
640081006674	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
640081006675	active site
640081006676	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
640081006677	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
640081006678	Walker A/P-loop; other site
640081006679	ATP binding site [chemical binding]; other site
640081006680	Q-loop/lid; other site
640081006681	ABC transporter signature motif; other site
640081006682	Walker B; other site
640081006683	D-loop; other site
640081006684	H-loop/switch region; other site
640081006685	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
640081006686	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
640081006687	Walker A/P-loop; other site
640081006688	ATP binding site [chemical binding]; other site
640081006689	Q-loop/lid; other site
640081006690	ABC transporter signature motif; other site
640081006691	Walker B; other site
640081006692	D-loop; other site
640081006693	H-loop/switch region; other site
640081006694	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
640081006695	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
640081006696	TM-ABC transporter signature motif; other site
640081006697	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
640081006698	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
640081006699	TM-ABC transporter signature motif; other site
640081006700	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
640081006701	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
640081006702	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
640081006703	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
640081006704	hypothetical protein; Provisional; Region: PRK09256
640081006705	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
640081006706	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
640081006707	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
640081006708	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
640081006709	Cupin domain; Region: Cupin_2; pfam07883
640081006710	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
640081006711	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
640081006712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081006713	dimer interface [polypeptide binding]; other site
640081006714	conserved gate region; other site
640081006715	ABC-ATPase subunit interface; other site
640081006716	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
640081006717	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
640081006718	Walker A/P-loop; other site
640081006719	ATP binding site [chemical binding]; other site
640081006720	Q-loop/lid; other site
640081006721	ABC transporter signature motif; other site
640081006722	Walker B; other site
640081006723	D-loop; other site
640081006724	H-loop/switch region; other site
640081006725	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
640081006726	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
640081006727	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
640081006728	acyl-activating enzyme (AAE) consensus motif; other site
640081006729	putative AMP binding site [chemical binding]; other site
640081006730	putative active site [active]
640081006731	putative CoA binding site [chemical binding]; other site
640081006732	LysR family transcriptional regulator; Provisional; Region: PRK14997
640081006733	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081006734	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
640081006735	putative effector binding pocket; other site
640081006736	dimerization interface [polypeptide binding]; other site
640081006737	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
640081006738	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
640081006739	Pirin-related protein [General function prediction only]; Region: COG1741
640081006740	Pirin; Region: Pirin; pfam02678
640081006741	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
640081006742	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
640081006743	Phasin protein; Region: Phasin_2; pfam09361
640081006744	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
640081006745	active site
640081006746	DNA polymerase IV; Validated; Region: PRK02406
640081006747	DNA binding site [nucleotide binding]
640081006748	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
640081006749	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
640081006750	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
640081006751	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081006752	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081006753	ligand binding site [chemical binding]; other site
640081006754	flexible hinge region; other site
640081006755	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
640081006756	non-specific DNA interactions [nucleotide binding]; other site
640081006757	DNA binding site [nucleotide binding]
640081006758	sequence specific DNA binding site [nucleotide binding]; other site
640081006759	putative cAMP binding site [chemical binding]; other site
640081006760	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
640081006761	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
640081006762	Cytochrome c; Region: Cytochrom_C; cl11414
640081006763	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
640081006764	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081006765	dimer interface [polypeptide binding]; other site
640081006766	phosphorylation site [posttranslational modification]
640081006767	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081006768	ATP binding site [chemical binding]; other site
640081006769	Mg2+ binding site [ion binding]; other site
640081006770	G-X-G motif; other site
640081006771	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
640081006772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081006773	active site
640081006774	phosphorylation site [posttranslational modification]
640081006775	intermolecular recognition site; other site
640081006776	dimerization interface [polypeptide binding]; other site
640081006777	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
640081006778	DNA binding residues [nucleotide binding]
640081006779	dimerization interface [polypeptide binding]; other site
640081006780	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
640081006781	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
640081006782	DNA-binding site [nucleotide binding]; DNA binding site
640081006783	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081006784	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081006785	homodimer interface [polypeptide binding]; other site
640081006786	catalytic residue [active]
640081006787	Uncharacterized conserved protein [Function unknown]; Region: COG2128
640081006788	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
640081006789	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
640081006790	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
640081006791	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
640081006792	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
640081006793	Cytochrome c; Region: Cytochrom_C; pfam00034
640081006794	Cytochrome c [Energy production and conversion]; Region: COG3258
640081006795	Cytochrome c; Region: Cytochrom_C; pfam00034
640081006796	Cytochrome c; Region: Cytochrom_C; cl11414
640081006797	Cytochrome c; Region: Cytochrom_C; cl11414
640081006798	Cytochrome c [Energy production and conversion]; Region: COG3258
640081006799	Cytochrome c; Region: Cytochrom_C; pfam00034
640081006800	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
640081006801	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
640081006802	NAD(P) binding site [chemical binding]; other site
640081006803	active site
640081006804	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081006805	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081006806	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
640081006807	putative effector binding pocket; other site
640081006808	putative dimerization interface [polypeptide binding]; other site
640081006809	TraB family; Region: TraB; pfam01963
640081006810	Autotransporter beta-domain; Region: Autotransporter; smart00869
640081006811	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081006812	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
640081006813	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081006814	HAMP domain; Region: HAMP; pfam00672
640081006815	dimerization interface [polypeptide binding]; other site
640081006816	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081006817	dimer interface [polypeptide binding]; other site
640081006818	putative CheW interface [polypeptide binding]; other site
640081006819	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
640081006820	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
640081006821	putative active site [active]
640081006822	putative metal binding site [ion binding]; other site
640081006823	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
640081006824	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081006825	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
640081006826	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
640081006827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081006828	Walker A motif; other site
640081006829	ATP binding site [chemical binding]; other site
640081006830	Walker B motif; other site
640081006831	arginine finger; other site
640081006832	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
640081006833	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
640081006834	Integrase core domain; Region: rve; pfam00665
640081006835	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
640081006836	ski2-like helicase; Provisional; Region: PRK02362
640081006837	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
640081006838	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
640081006839	ATP binding site [chemical binding]; other site
640081006840	ATP binding site [chemical binding]; other site
640081006841	putative Mg++ binding site [ion binding]; other site
640081006842	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
640081006843	nucleotide binding region [chemical binding]; other site
640081006844	ATP-binding site [chemical binding]; other site
640081006845	Transposase; Region: DEDD_Tnp_IS110; pfam01548
640081006846	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
640081006847	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
640081006848	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
640081006849	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
640081006850	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
640081006851	catalytic residue [active]
640081006852	serine O-acetyltransferase; Region: cysE; TIGR01172
640081006853	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
640081006854	trimer interface [polypeptide binding]; other site
640081006855	active site
640081006856	substrate binding site [chemical binding]; other site
640081006857	CoA binding site [chemical binding]; other site
640081006858	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
640081006859	active site residue [active]
640081006860	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081006861	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081006862	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
640081006863	putative effector binding pocket; other site
640081006864	dimerization interface [polypeptide binding]; other site
640081006865	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
640081006866	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
640081006867	dimer interface [polypeptide binding]; other site
640081006868	active site
640081006869	metal binding site [ion binding]; metal-binding site
640081006870	Coenzyme A transferase; Region: CoA_trans; cl17247
640081006871	Coenzyme A transferase; Region: CoA_trans; smart00882
640081006872	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
640081006873	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
640081006874	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
640081006875	Cu(I) binding site [ion binding]; other site
640081006876	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
640081006877	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081006878	dimer interface [polypeptide binding]; other site
640081006879	conserved gate region; other site
640081006880	putative PBP binding loops; other site
640081006881	ABC-ATPase subunit interface; other site
640081006882	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
640081006883	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
640081006884	Walker A/P-loop; other site
640081006885	ATP binding site [chemical binding]; other site
640081006886	Q-loop/lid; other site
640081006887	ABC transporter signature motif; other site
640081006888	Walker B; other site
640081006889	D-loop; other site
640081006890	H-loop/switch region; other site
640081006891	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
640081006892	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
640081006893	substrate binding pocket [chemical binding]; other site
640081006894	membrane-bound complex binding site; other site
640081006895	hinge residues; other site
640081006896	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081006897	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081006898	dimer interface [polypeptide binding]; other site
640081006899	putative CheW interface [polypeptide binding]; other site
640081006900	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
640081006901	PAS fold; Region: PAS_4; pfam08448
640081006902	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081006903	putative active site [active]
640081006904	heme pocket [chemical binding]; other site
640081006905	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081006906	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081006907	dimer interface [polypeptide binding]; other site
640081006908	phosphorylation site [posttranslational modification]
640081006909	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081006910	ATP binding site [chemical binding]; other site
640081006911	Mg2+ binding site [ion binding]; other site
640081006912	G-X-G motif; other site
640081006913	Response regulator receiver domain; Region: Response_reg; pfam00072
640081006914	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081006915	active site
640081006916	phosphorylation site [posttranslational modification]
640081006917	intermolecular recognition site; other site
640081006918	dimerization interface [polypeptide binding]; other site
640081006919	PAS domain S-box; Region: sensory_box; TIGR00229
640081006920	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081006921	putative active site [active]
640081006922	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081006923	heme pocket [chemical binding]; other site
640081006924	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081006925	dimer interface [polypeptide binding]; other site
640081006926	phosphorylation site [posttranslational modification]
640081006927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081006928	ATP binding site [chemical binding]; other site
640081006929	Mg2+ binding site [ion binding]; other site
640081006930	G-X-G motif; other site
640081006931	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
640081006932	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
640081006933	hexamer interface [polypeptide binding]; other site
640081006934	ligand binding site [chemical binding]; other site
640081006935	putative active site [active]
640081006936	NAD(P) binding site [chemical binding]; other site
640081006937	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
640081006938	ferredoxin-NADP reductase; Provisional; Region: PRK10926
640081006939	FAD binding pocket [chemical binding]; other site
640081006940	FAD binding motif [chemical binding]; other site
640081006941	phosphate binding motif [ion binding]; other site
640081006942	beta-alpha-beta structure motif; other site
640081006943	NAD binding pocket [chemical binding]; other site
640081006944	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
640081006945	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
640081006946	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
640081006947	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
640081006948	ligand binding site [chemical binding]; other site
640081006949	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
640081006950	IHF dimer interface [polypeptide binding]; other site
640081006951	IHF - DNA interface [nucleotide binding]; other site
640081006952	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
640081006953	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081006954	N-terminal plug; other site
640081006955	ligand-binding site [chemical binding]; other site
640081006956	aspartate kinase; Reviewed; Region: PRK06635
640081006957	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
640081006958	putative nucleotide binding site [chemical binding]; other site
640081006959	putative catalytic residues [active]
640081006960	putative Mg ion binding site [ion binding]; other site
640081006961	putative aspartate binding site [chemical binding]; other site
640081006962	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
640081006963	putative allosteric regulatory site; other site
640081006964	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
640081006965	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
640081006966	non-specific DNA binding site [nucleotide binding]; other site
640081006967	salt bridge; other site
640081006968	sequence-specific DNA binding site [nucleotide binding]; other site
640081006969	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081006970	FeS/SAM binding site; other site
640081006971	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
640081006972	active site
640081006973	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
640081006974	Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
640081006975	hypothetical protein; Provisional; Region: PRK09040
640081006976	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
640081006977	ligand binding site [chemical binding]; other site
640081006978	Protein of unknown function (DUF2894); Region: DUF2894; pfam11445
640081006979	Protein of unknown function (DUF2894); Region: DUF2894; pfam11445
640081006980	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
640081006981	YccA-like proteins; Region: YccA_like; cd10433
640081006982	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
640081006983	IHF - DNA interface [nucleotide binding]; other site
640081006984	IHF dimer interface [polypeptide binding]; other site
640081006985	recombination associated protein; Reviewed; Region: rdgC; PRK00321
640081006986	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
640081006987	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
640081006988	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081006989	PAS domain; Region: PAS_9; pfam13426
640081006990	putative active site [active]
640081006991	heme pocket [chemical binding]; other site
640081006992	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081006993	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081006994	metal binding site [ion binding]; metal-binding site
640081006995	active site
640081006996	I-site; other site
640081006997	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081006998	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
640081006999	DEAD/DEAH box helicase; Region: DEAD; pfam00270
640081007000	ATP binding site [chemical binding]; other site
640081007001	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
640081007002	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
640081007003	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
640081007004	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
640081007005	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
640081007006	dimer interface [polypeptide binding]; other site
640081007007	putative functional site; other site
640081007008	putative MPT binding site; other site
640081007009	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
640081007010	MoaE interaction surface [polypeptide binding]; other site
640081007011	MoeB interaction surface [polypeptide binding]; other site
640081007012	thiocarboxylated glycine; other site
640081007013	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
640081007014	MoaE homodimer interface [polypeptide binding]; other site
640081007015	MoaD interaction [polypeptide binding]; other site
640081007016	active site residues [active]
640081007017	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
640081007018	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081007019	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081007020	dimer interface [polypeptide binding]; other site
640081007021	putative CheW interface [polypeptide binding]; other site
640081007022	PAS domain S-box; Region: sensory_box; TIGR00229
640081007023	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007024	putative active site [active]
640081007025	heme pocket [chemical binding]; other site
640081007026	PAS fold; Region: PAS_4; pfam08448
640081007027	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007028	PAS fold; Region: PAS_3; pfam08447
640081007029	putative active site [active]
640081007030	heme pocket [chemical binding]; other site
640081007031	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
640081007032	Histidine kinase; Region: HisKA_3; pfam07730
640081007033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081007034	ATP binding site [chemical binding]; other site
640081007035	Mg2+ binding site [ion binding]; other site
640081007036	G-X-G motif; other site
640081007037	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
640081007038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081007039	active site
640081007040	phosphorylation site [posttranslational modification]
640081007041	intermolecular recognition site; other site
640081007042	dimerization interface [polypeptide binding]; other site
640081007043	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
640081007044	DNA binding residues [nucleotide binding]
640081007045	dimerization interface [polypeptide binding]; other site
640081007046	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081007047	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007048	PAS domain; Region: PAS_9; pfam13426
640081007049	putative active site [active]
640081007050	heme pocket [chemical binding]; other site
640081007051	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081007052	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081007053	metal binding site [ion binding]; metal-binding site
640081007054	active site
640081007055	I-site; other site
640081007056	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081007057	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
640081007058	Clp amino terminal domain; Region: Clp_N; pfam02861
640081007059	Clp amino terminal domain; Region: Clp_N; pfam02861
640081007060	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081007061	Walker A motif; other site
640081007062	ATP binding site [chemical binding]; other site
640081007063	Walker B motif; other site
640081007064	arginine finger; other site
640081007065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081007066	Walker A motif; other site
640081007067	ATP binding site [chemical binding]; other site
640081007068	Walker B motif; other site
640081007069	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
640081007070	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
640081007071	Cache domain; Region: Cache_1; pfam02743
640081007072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081007073	dimer interface [polypeptide binding]; other site
640081007074	phosphorylation site [posttranslational modification]
640081007075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081007076	ATP binding site [chemical binding]; other site
640081007077	Mg2+ binding site [ion binding]; other site
640081007078	G-X-G motif; other site
640081007079	RNA polymerase sigma factor; Reviewed; Region: PRK12523
640081007080	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081007081	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081007082	DNA binding residues [nucleotide binding]
640081007083	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
640081007084	FecR protein; Region: FecR; pfam04773
640081007085	Secretin and TonB N terminus short domain; Region: STN; smart00965
640081007086	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
640081007087	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081007088	N-terminal plug; other site
640081007089	ligand-binding site [chemical binding]; other site
640081007090	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
640081007091	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
640081007092	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
640081007093	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
640081007094	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
640081007095	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
640081007096	MarR family; Region: MarR; pfam01047
640081007097	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
640081007098	HDOD domain; Region: HDOD; pfam08668
640081007099	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
640081007100	phosphoglyceromutase; Provisional; Region: PRK05434
640081007101	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
640081007102	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
640081007103	nucleophile elbow; other site
640081007104	Methyltransferase domain; Region: Methyltransf_23; pfam13489
640081007105	Methyltransferase domain; Region: Methyltransf_11; pfam08241
640081007106	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
640081007107	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
640081007108	Cupin domain; Region: Cupin_2; cl17218
640081007109	Helix-turn-helix domain; Region: HTH_18; pfam12833
640081007110	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
640081007111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
640081007112	Major Facilitator Superfamily; Region: MFS_1; pfam07690
640081007113	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
640081007114	active site
640081007115	phosphate binding residues; other site
640081007116	catalytic residues [active]
640081007117	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
640081007118	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
640081007119	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
640081007120	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
640081007121	active site
640081007122	acyl-activating enzyme (AAE) consensus motif; other site
640081007123	putative CoA binding site [chemical binding]; other site
640081007124	AMP binding site [chemical binding]; other site
640081007125	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
640081007126	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
640081007127	CoA binding domain; Region: CoA_binding_2; pfam13380
640081007128	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
640081007129	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
640081007130	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
640081007131	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
640081007132	Coenzyme A binding pocket [chemical binding]; other site
640081007133	Methyltransferase domain; Region: Methyltransf_23; pfam13489
640081007134	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
640081007135	S-adenosylmethionine binding site [chemical binding]; other site
640081007136	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
640081007137	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
640081007138	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
640081007139	active site lid residues [active]
640081007140	substrate binding pocket [chemical binding]; other site
640081007141	catalytic residues [active]
640081007142	substrate-Mg2+ binding site; other site
640081007143	aspartate-rich region 1; other site
640081007144	aspartate-rich region 2; other site
640081007145	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
640081007146	active site lid residues [active]
640081007147	substrate binding pocket [chemical binding]; other site
640081007148	catalytic residues [active]
640081007149	substrate-Mg2+ binding site; other site
640081007150	aspartate-rich region 1; other site
640081007151	aspartate-rich region 2; other site
640081007152	trigger factor; Provisional; Region: tig; PRK01490
640081007153	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
640081007154	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
640081007155	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
640081007156	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
640081007157	oligomer interface [polypeptide binding]; other site
640081007158	active site residues [active]
640081007159	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
640081007160	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
640081007161	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081007162	Walker A motif; other site
640081007163	ATP binding site [chemical binding]; other site
640081007164	Walker B motif; other site
640081007165	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
640081007166	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
640081007167	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081007168	Walker A motif; other site
640081007169	ATP binding site [chemical binding]; other site
640081007170	Walker B motif; other site
640081007171	arginine finger; other site
640081007172	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
640081007173	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
640081007174	IHF dimer interface [polypeptide binding]; other site
640081007175	IHF - DNA interface [nucleotide binding]; other site
640081007176	periplasmic folding chaperone; Provisional; Region: PRK10788
640081007177	SurA N-terminal domain; Region: SurA_N_3; pfam13624
640081007178	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
640081007179	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
640081007180	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
640081007181	NAD binding site [chemical binding]; other site
640081007182	homotetramer interface [polypeptide binding]; other site
640081007183	homodimer interface [polypeptide binding]; other site
640081007184	substrate binding site [chemical binding]; other site
640081007185	active site
640081007186	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
640081007187	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
640081007188	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
640081007189	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
640081007190	substrate binding site [chemical binding]; other site
640081007191	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
640081007192	substrate binding site [chemical binding]; other site
640081007193	ligand binding site [chemical binding]; other site
640081007194	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
640081007195	NnrS protein; Region: NnrS; pfam05940
640081007196	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
640081007197	malate dehydrogenase; Provisional; Region: PRK05442
640081007198	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
640081007199	NAD(P) binding site [chemical binding]; other site
640081007200	dimer interface [polypeptide binding]; other site
640081007201	malate binding site [chemical binding]; other site
640081007202	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
640081007203	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
640081007204	DNA-binding site [nucleotide binding]; DNA binding site
640081007205	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
640081007206	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
640081007207	Iron-sulfur protein interface; other site
640081007208	proximal quinone binding site [chemical binding]; other site
640081007209	SdhD (CybS) interface [polypeptide binding]; other site
640081007210	proximal heme binding site [chemical binding]; other site
640081007211	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
640081007212	SdhC subunit interface [polypeptide binding]; other site
640081007213	proximal heme binding site [chemical binding]; other site
640081007214	cardiolipin binding site; other site
640081007215	Iron-sulfur protein interface; other site
640081007216	proximal quinone binding site [chemical binding]; other site
640081007217	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
640081007218	L-aspartate oxidase; Provisional; Region: PRK06175
640081007219	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
640081007220	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
640081007221	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
640081007222	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
640081007223	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
640081007224	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
640081007225	dimer interface [polypeptide binding]; other site
640081007226	active site
640081007227	citrylCoA binding site [chemical binding]; other site
640081007228	NADH binding [chemical binding]; other site
640081007229	cationic pore residues; other site
640081007230	oxalacetate/citrate binding site [chemical binding]; other site
640081007231	coenzyme A binding site [chemical binding]; other site
640081007232	catalytic triad [active]
640081007233	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
640081007234	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
640081007235	TPP-binding site [chemical binding]; other site
640081007236	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
640081007237	PYR/PP interface [polypeptide binding]; other site
640081007238	dimer interface [polypeptide binding]; other site
640081007239	TPP binding site [chemical binding]; other site
640081007240	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
640081007241	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
640081007242	E3 interaction surface; other site
640081007243	lipoyl attachment site [posttranslational modification]; other site
640081007244	e3 binding domain; Region: E3_binding; pfam02817
640081007245	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
640081007246	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
640081007247	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
640081007248	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
640081007249	Predicted ATPase [General function prediction only]; Region: COG1485
640081007250	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
640081007251	AAA domain; Region: AAA_32; pfam13654
640081007252	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
640081007253	Protein of unknown function (DUF454); Region: DUF454; pfam04304
640081007254	Helix-turn-helix domain; Region: HTH_18; pfam12833
640081007255	NADH dehydrogenase subunit B; Validated; Region: PRK06411
640081007256	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
640081007257	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
640081007258	NAD binding site [chemical binding]; other site
640081007259	substrate binding site [chemical binding]; other site
640081007260	catalytic Zn binding site [ion binding]; other site
640081007261	tetramer interface [polypeptide binding]; other site
640081007262	structural Zn binding site [ion binding]; other site
640081007263	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
640081007264	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081007265	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
640081007266	putative dimerization interface [polypeptide binding]; other site
640081007267	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
640081007268	H+ Antiporter protein; Region: 2A0121; TIGR00900
640081007269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
640081007270	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
640081007271	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
640081007272	dimer interface [polypeptide binding]; other site
640081007273	active site
640081007274	heme binding site [chemical binding]; other site
640081007275	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
640081007276	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
640081007277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081007278	putative PBP binding loops; other site
640081007279	ABC-ATPase subunit interface; other site
640081007280	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
640081007281	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081007282	dimer interface [polypeptide binding]; other site
640081007283	conserved gate region; other site
640081007284	putative PBP binding loops; other site
640081007285	ABC-ATPase subunit interface; other site
640081007286	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
640081007287	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
640081007288	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
640081007289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081007290	S-adenosylmethionine binding site [chemical binding]; other site
640081007291	PAS domain; Region: PAS_9; pfam13426
640081007292	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007293	putative active site [active]
640081007294	heme pocket [chemical binding]; other site
640081007295	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081007296	dimer interface [polypeptide binding]; other site
640081007297	phosphorylation site [posttranslational modification]
640081007298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081007299	ATP binding site [chemical binding]; other site
640081007300	Mg2+ binding site [ion binding]; other site
640081007301	G-X-G motif; other site
640081007302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081007303	active site
640081007304	phosphorylation site [posttranslational modification]
640081007305	intermolecular recognition site; other site
640081007306	dimerization interface [polypeptide binding]; other site
640081007307	Response regulator receiver domain; Region: Response_reg; pfam00072
640081007308	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081007309	active site
640081007310	phosphorylation site [posttranslational modification]
640081007311	intermolecular recognition site; other site
640081007312	dimerization interface [polypeptide binding]; other site
640081007313	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
640081007314	putative binding surface; other site
640081007315	active site
640081007316	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
640081007317	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
640081007318	homodimer interface [polypeptide binding]; other site
640081007319	substrate-cofactor binding pocket; other site
640081007320	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081007321	catalytic residue [active]
640081007322	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
640081007323	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
640081007324	MutS domain I; Region: MutS_I; pfam01624
640081007325	MutS domain II; Region: MutS_II; pfam05188
640081007326	MutS domain III; Region: MutS_III; pfam05192
640081007327	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
640081007328	Walker A/P-loop; other site
640081007329	ATP binding site [chemical binding]; other site
640081007330	Q-loop/lid; other site
640081007331	ABC transporter signature motif; other site
640081007332	Walker B; other site
640081007333	D-loop; other site
640081007334	H-loop/switch region; other site
640081007335	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
640081007336	Dihaem cytochrome c; Region: DHC; pfam09626
640081007337	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
640081007338	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
640081007339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081007340	active site
640081007341	phosphorylation site [posttranslational modification]
640081007342	intermolecular recognition site; other site
640081007343	dimerization interface [polypeptide binding]; other site
640081007344	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081007345	DNA binding site [nucleotide binding]
640081007346	sensor protein QseC; Provisional; Region: PRK10337
640081007347	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081007348	dimer interface [polypeptide binding]; other site
640081007349	phosphorylation site [posttranslational modification]
640081007350	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081007351	ATP binding site [chemical binding]; other site
640081007352	Mg2+ binding site [ion binding]; other site
640081007353	G-X-G motif; other site
640081007354	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081007355	Zn2+ binding site [ion binding]; other site
640081007356	Mg2+ binding site [ion binding]; other site
640081007357	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
640081007358	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081007359	Zn2+ binding site [ion binding]; other site
640081007360	Mg2+ binding site [ion binding]; other site
640081007361	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081007362	dimer interface [polypeptide binding]; other site
640081007363	phosphorylation site [posttranslational modification]
640081007364	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081007365	ATP binding site [chemical binding]; other site
640081007366	Mg2+ binding site [ion binding]; other site
640081007367	G-X-G motif; other site
640081007368	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
640081007369	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
640081007370	DNA-binding site [nucleotide binding]; DNA binding site
640081007371	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081007372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081007373	homodimer interface [polypeptide binding]; other site
640081007374	catalytic residue [active]
640081007375	benzoate transporter; Region: benE; TIGR00843
640081007376	Benzoate membrane transport protein; Region: BenE; pfam03594
640081007377	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
640081007378	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
640081007379	dimer interface [polypeptide binding]; other site
640081007380	active site
640081007381	glycine-pyridoxal phosphate binding site [chemical binding]; other site
640081007382	folate binding site [chemical binding]; other site
640081007383	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
640081007384	ligand binding site [chemical binding]; other site
640081007385	flexible hinge region; other site
640081007386	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
640081007387	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
640081007388	FAD binding pocket [chemical binding]; other site
640081007389	FAD binding motif [chemical binding]; other site
640081007390	phosphate binding motif [ion binding]; other site
640081007391	beta-alpha-beta structure motif; other site
640081007392	NAD binding pocket [chemical binding]; other site
640081007393	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
640081007394	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081007395	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
640081007396	putative dimerization interface [polypeptide binding]; other site
640081007397	Cupin domain; Region: Cupin_2; cl17218
640081007398	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
640081007399	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
640081007400	DNA-binding site [nucleotide binding]; DNA binding site
640081007401	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081007402	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081007403	homodimer interface [polypeptide binding]; other site
640081007404	catalytic residue [active]
640081007405	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
640081007406	HD domain; Region: HD_3; pfam13023
640081007407	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
640081007408	synthetase active site [active]
640081007409	NTP binding site [chemical binding]; other site
640081007410	metal binding site [ion binding]; metal-binding site
640081007411	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
640081007412	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
640081007413	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
640081007414	putative active site [active]
640081007415	putative PHP Thumb interface [polypeptide binding]; other site
640081007416	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
640081007417	generic binding surface II; other site
640081007418	generic binding surface I; other site
640081007419	DNA Polymerase Y-family; Region: PolY_like; cd03468
640081007420	active site
640081007421	DNA binding site [nucleotide binding]
640081007422	Uncharacterized conserved protein [Function unknown]; Region: COG4544
640081007423	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
640081007424	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
640081007425	LexA repressor; Validated; Region: PRK00215
640081007426	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
640081007427	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
640081007428	Catalytic site [active]
640081007429	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
640081007430	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
640081007431	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
640081007432	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081007433	N-terminal plug; other site
640081007434	ligand-binding site [chemical binding]; other site
640081007435	Predicted transcriptional regulator [Transcription]; Region: COG3655
640081007436	salt bridge; other site
640081007437	non-specific DNA binding site [nucleotide binding]; other site
640081007438	sequence-specific DNA binding site [nucleotide binding]; other site
640081007439	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
640081007440	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
640081007441	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
640081007442	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
640081007443	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
640081007444	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
640081007445	PGAP1-like protein; Region: PGAP1; pfam07819
640081007446	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
640081007447	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
640081007448	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
640081007449	aminopeptidase N; Provisional; Region: pepN; PRK14015
640081007450	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
640081007451	active site
640081007452	Zn binding site [ion binding]; other site
640081007453	Protein of unknown function (DUF330); Region: DUF330; pfam03886
640081007454	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
640081007455	mce related protein; Region: MCE; pfam02470
640081007456	mce related protein; Region: MCE; pfam02470
640081007457	mce related protein; Region: MCE; pfam02470
640081007458	Paraquat-inducible protein A; Region: PqiA; pfam04403
640081007459	Paraquat-inducible protein A; Region: PqiA; pfam04403
640081007460	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
640081007461	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cd00590
640081007462	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
640081007463	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
640081007464	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
640081007465	Phasin protein; Region: Phasin_2; pfam09361
640081007466	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
640081007467	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
640081007468	CheD chemotactic sensory transduction; Region: CheD; cl00810
640081007469	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
640081007470	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
640081007471	acyl-activating enzyme (AAE) consensus motif; other site
640081007472	putative AMP binding site [chemical binding]; other site
640081007473	putative active site [active]
640081007474	putative CoA binding site [chemical binding]; other site
640081007475	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
640081007476	active site
640081007477	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
640081007478	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
640081007479	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081007480	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
640081007481	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081007482	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081007483	metal binding site [ion binding]; metal-binding site
640081007484	active site
640081007485	I-site; other site
640081007486	Cache domain; Region: Cache_1; pfam02743
640081007487	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
640081007488	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
640081007489	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
640081007490	active site
640081007491	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
640081007492	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
640081007493	Predicted membrane protein [Function unknown]; Region: COG3235
640081007494	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
640081007495	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
640081007496	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
640081007497	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
640081007498	Ligand binding site [chemical binding]; other site
640081007499	Electron transfer flavoprotein domain; Region: ETF; pfam01012
640081007500	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
640081007501	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
640081007502	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
640081007503	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
640081007504	Walker A/P-loop; other site
640081007505	ATP binding site [chemical binding]; other site
640081007506	Q-loop/lid; other site
640081007507	ABC transporter signature motif; other site
640081007508	Walker B; other site
640081007509	D-loop; other site
640081007510	H-loop/switch region; other site
640081007511	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
640081007512	active site
640081007513	catalytic triad [active]
640081007514	oxyanion hole [active]
640081007515	switch loop; other site
640081007516	selenophosphate synthetase; Provisional; Region: PRK00943
640081007517	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
640081007518	dimerization interface [polypeptide binding]; other site
640081007519	putative ATP binding site [chemical binding]; other site
640081007520	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
640081007521	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
640081007522	active site residue [active]
640081007523	AAA domain; Region: AAA_17; cl17253
640081007524	Isochorismatase family; Region: Isochorismatase; pfam00857
640081007525	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
640081007526	catalytic triad [active]
640081007527	dimer interface [polypeptide binding]; other site
640081007528	conserved cis-peptide bond; other site
640081007529	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
640081007530	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
640081007531	NAD(P) binding site [chemical binding]; other site
640081007532	active site
640081007533	CTP synthetase; Validated; Region: pyrG; PRK05380
640081007534	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
640081007535	Catalytic site [active]
640081007536	active site
640081007537	UTP binding site [chemical binding]; other site
640081007538	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
640081007539	active site
640081007540	putative oxyanion hole; other site
640081007541	catalytic triad [active]
640081007542	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
640081007543	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
640081007544	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
640081007545	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
640081007546	enolase; Provisional; Region: eno; PRK00077
640081007547	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
640081007548	dimer interface [polypeptide binding]; other site
640081007549	metal binding site [ion binding]; metal-binding site
640081007550	substrate binding pocket [chemical binding]; other site
640081007551	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
640081007552	Septum formation initiator; Region: DivIC; cl17659
640081007553	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
640081007554	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
640081007555	putative Zn2+ binding site [ion binding]; other site
640081007556	putative DNA binding site [nucleotide binding]; other site
640081007557	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
640081007558	Coenzyme A binding pocket [chemical binding]; other site
640081007559	Protein of unknown function (DUF2863); Region: DUF2863; pfam11062
640081007560	Site-specific recombinase; Region: SpecificRecomb; pfam10136
640081007561	hypothetical protein; Validated; Region: PRK02101
640081007562	DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863
640081007563	putative hydrophobic ligand binding site [chemical binding]; other site
640081007564	hypothetical protein; Provisional; Region: PRK01842
640081007565	SEC-C motif; Region: SEC-C; pfam02810
640081007566	PIN domain; Region: PIN_3; pfam13470
640081007567	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
640081007568	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
640081007569	putative active site [active]
640081007570	putative metal binding site [ion binding]; other site
640081007571	hydroxyglutarate oxidase; Provisional; Region: PRK11728
640081007572	Predicted dehydrogenase [General function prediction only]; Region: COG0579
640081007573	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
640081007574	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
640081007575	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
640081007576	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
640081007577	NlpE N-terminal domain; Region: NlpE; pfam04170
640081007578	META domain; Region: META; pfam03724
640081007579	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
640081007580	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
640081007581	active site
640081007582	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
640081007583	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
640081007584	FMN binding site [chemical binding]; other site
640081007585	active site
640081007586	catalytic residues [active]
640081007587	substrate binding site [chemical binding]; other site
640081007588	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
640081007589	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
640081007590	GEMM cis-regulatory element
640081007591	HDOD domain; Region: HDOD; pfam08668
640081007592	HD domain; Region: HD; pfam01966
640081007593	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
640081007594	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
640081007595	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
640081007596	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
640081007597	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
640081007598	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
640081007599	Walker A/P-loop; other site
640081007600	ATP binding site [chemical binding]; other site
640081007601	Q-loop/lid; other site
640081007602	ABC transporter signature motif; other site
640081007603	Walker B; other site
640081007604	D-loop; other site
640081007605	H-loop/switch region; other site
640081007606	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081007607	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
640081007608	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
640081007609	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
640081007610	RNA binding surface [nucleotide binding]; other site
640081007611	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
640081007612	aconitate hydratase; Validated; Region: PRK09277
640081007613	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
640081007614	substrate binding site [chemical binding]; other site
640081007615	ligand binding site [chemical binding]; other site
640081007616	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
640081007617	substrate binding site [chemical binding]; other site
640081007618	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
640081007619	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
640081007620	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
640081007621	DNA binding residues [nucleotide binding]
640081007622	putative dimer interface [polypeptide binding]; other site
640081007623	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
640081007624	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081007625	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081007626	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
640081007627	putative effector binding pocket; other site
640081007628	dimerization interface [polypeptide binding]; other site
640081007629	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
640081007630	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
640081007631	putative active site [active]
640081007632	metal binding site [ion binding]; metal-binding site
640081007633	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
640081007634	YceI-like domain; Region: YceI; smart00867
640081007635	Uncharacterized conserved protein [Function unknown]; Region: COG2353
640081007636	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081007637	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081007638	dimerization interface [polypeptide binding]; other site
640081007639	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081007640	dimer interface [polypeptide binding]; other site
640081007641	phosphorylation site [posttranslational modification]
640081007642	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081007643	ATP binding site [chemical binding]; other site
640081007644	Mg2+ binding site [ion binding]; other site
640081007645	G-X-G motif; other site
640081007646	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081007647	response regulator GlrR; Provisional; Region: PRK15115
640081007648	active site
640081007649	phosphorylation site [posttranslational modification]
640081007650	intermolecular recognition site; other site
640081007651	dimerization interface [polypeptide binding]; other site
640081007652	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081007653	Walker A motif; other site
640081007654	ATP binding site [chemical binding]; other site
640081007655	Walker B motif; other site
640081007656	arginine finger; other site
640081007657	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
640081007658	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
640081007659	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
640081007660	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007661	PAS domain; Region: PAS_9; pfam13426
640081007662	putative active site [active]
640081007663	heme pocket [chemical binding]; other site
640081007664	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081007665	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081007666	metal binding site [ion binding]; metal-binding site
640081007667	active site
640081007668	I-site; other site
640081007669	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081007670	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
640081007671	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
640081007672	active site
640081007673	dimerization interface [polypeptide binding]; other site
640081007674	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
640081007675	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
640081007676	serine O-acetyltransferase; Region: cysE; TIGR01172
640081007677	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
640081007678	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
640081007679	trimer interface [polypeptide binding]; other site
640081007680	active site
640081007681	substrate binding site [chemical binding]; other site
640081007682	CoA binding site [chemical binding]; other site
640081007683	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
640081007684	Rrf2 family protein; Region: rrf2_super; TIGR00738
640081007685	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
640081007686	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
640081007687	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
640081007688	catalytic residue [active]
640081007689	cysteine desulfurase; Provisional; Region: PRK14012
640081007690	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
640081007691	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
640081007692	catalytic residue [active]
640081007693	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
640081007694	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
640081007695	trimerization site [polypeptide binding]; other site
640081007696	active site
640081007697	iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011
640081007698	co-chaperone HscB; Provisional; Region: hscB; PRK03578
640081007699	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
640081007700	HSP70 interaction site [polypeptide binding]; other site
640081007701	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
640081007702	chaperone protein HscA; Provisional; Region: hscA; PRK05183
640081007703	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
640081007704	nucleotide binding site [chemical binding]; other site
640081007705	putative NEF/HSP70 interaction site [polypeptide binding]; other site
640081007706	SBD interface [polypeptide binding]; other site
640081007707	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
640081007708	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
640081007709	catalytic loop [active]
640081007710	iron binding site [ion binding]; other site
640081007711	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
640081007712	phosphoserine phosphatase SerB; Region: serB; TIGR00338
640081007713	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
640081007714	motif II; other site
640081007715	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
640081007716	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
640081007717	trimer interface [polypeptide binding]; other site
640081007718	putative metal binding site [ion binding]; other site
640081007719	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
640081007720	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
640081007721	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007722	PAS domain; Region: PAS_9; pfam13426
640081007723	putative active site [active]
640081007724	heme pocket [chemical binding]; other site
640081007725	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081007726	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081007727	dimer interface [polypeptide binding]; other site
640081007728	phosphorylation site [posttranslational modification]
640081007729	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081007730	ATP binding site [chemical binding]; other site
640081007731	Mg2+ binding site [ion binding]; other site
640081007732	G-X-G motif; other site
640081007733	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
640081007734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081007735	active site
640081007736	phosphorylation site [posttranslational modification]
640081007737	intermolecular recognition site; other site
640081007738	dimerization interface [polypeptide binding]; other site
640081007739	Response regulator receiver domain; Region: Response_reg; pfam00072
640081007740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081007741	active site
640081007742	phosphorylation site [posttranslational modification]
640081007743	intermolecular recognition site; other site
640081007744	dimerization interface [polypeptide binding]; other site
640081007745	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
640081007746	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
640081007747	putative ligand binding site [chemical binding]; other site
640081007748	Patatin-like phospholipase; Region: Patatin; pfam01734
640081007749	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
640081007750	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
640081007751	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
640081007752	ATP binding site [chemical binding]; other site
640081007753	putative Mg++ binding site [ion binding]; other site
640081007754	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
640081007755	nucleotide binding region [chemical binding]; other site
640081007756	ATP-binding site [chemical binding]; other site
640081007757	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
640081007758	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
640081007759	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081007760	FeS/SAM binding site; other site
640081007761	AMMECR1; Region: AMMECR1; cl00911
640081007762	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
640081007763	putative ligand binding pocket/active site [active]
640081007764	putative metal binding site [ion binding]; other site
640081007765	Predicted membrane protein [Function unknown]; Region: COG3174
640081007766	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
640081007767	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
640081007768	substrate binding site; other site
640081007769	dimer interface; other site
640081007770	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
640081007771	homotrimer interaction site [polypeptide binding]; other site
640081007772	zinc binding site [ion binding]; other site
640081007773	CDP-binding sites; other site
640081007774	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
640081007775	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
640081007776	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
640081007777	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
640081007778	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081007779	Zn2+ binding site [ion binding]; other site
640081007780	Mg2+ binding site [ion binding]; other site
640081007781	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007782	PAS fold; Region: PAS_3; pfam08447
640081007783	putative active site [active]
640081007784	heme pocket [chemical binding]; other site
640081007785	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081007786	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081007787	metal binding site [ion binding]; metal-binding site
640081007788	active site
640081007789	I-site; other site
640081007790	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081007791	HDOD domain; Region: HDOD; pfam08668
640081007792	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081007793	Zn2+ binding site [ion binding]; other site
640081007794	Mg2+ binding site [ion binding]; other site
640081007795	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081007796	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081007797	ligand binding site [chemical binding]; other site
640081007798	flexible hinge region; other site
640081007799	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
640081007800	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
640081007801	active site
640081007802	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081007803	dimer interface [polypeptide binding]; other site
640081007804	phosphorylation site [posttranslational modification]
640081007805	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081007806	ATP binding site [chemical binding]; other site
640081007807	Mg2+ binding site [ion binding]; other site
640081007808	G-X-G motif; other site
640081007809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081007810	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
640081007811	active site
640081007812	phosphorylation site [posttranslational modification]
640081007813	intermolecular recognition site; other site
640081007814	dimerization interface [polypeptide binding]; other site
640081007815	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081007816	DNA binding site [nucleotide binding]
640081007817	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
640081007818	Glycoprotease family; Region: Peptidase_M22; pfam00814
640081007819	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
640081007820	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
640081007821	Coenzyme A binding pocket [chemical binding]; other site
640081007822	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
640081007823	active site
640081007824	Fe-S cluster binding site [ion binding]; other site
640081007825	LemA family; Region: LemA; pfam04011
640081007826	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
640081007827	Repair protein; Region: Repair_PSII; pfam04536
640081007828	Repair protein; Region: Repair_PSII; cl01535
640081007829	lysophospholipid transporter LplT; Provisional; Region: PRK11195
640081007830	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081007831	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081007832	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
640081007833	putative dimerization interface [polypeptide binding]; other site
640081007834	alanine racemase; Reviewed; Region: alr; PRK00053
640081007835	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
640081007836	active site
640081007837	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
640081007838	substrate binding site [chemical binding]; other site
640081007839	catalytic residues [active]
640081007840	dimer interface [polypeptide binding]; other site
640081007841	NMT1/THI5 like; Region: NMT1; pfam09084
640081007842	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007843	PAS domain; Region: PAS_9; pfam13426
640081007844	putative active site [active]
640081007845	heme pocket [chemical binding]; other site
640081007846	PAS domain S-box; Region: sensory_box; TIGR00229
640081007847	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007848	putative active site [active]
640081007849	heme pocket [chemical binding]; other site
640081007850	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007851	PAS domain; Region: PAS_9; pfam13426
640081007852	putative active site [active]
640081007853	heme pocket [chemical binding]; other site
640081007854	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081007855	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081007856	metal binding site [ion binding]; metal-binding site
640081007857	active site
640081007858	I-site; other site
640081007859	DNA repair protein RadA; Provisional; Region: PRK11823
640081007860	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
640081007861	Walker A motif/ATP binding site; other site
640081007862	ATP binding site [chemical binding]; other site
640081007863	Walker B motif; other site
640081007864	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
640081007865	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
640081007866	FtsX-like permease family; Region: FtsX; pfam02687
640081007867	FtsX-like permease family; Region: FtsX; pfam02687
640081007868	TIR domain; Region: TIR_2; pfam13676
640081007869	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
640081007870	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
640081007871	G1 box; other site
640081007872	putative GEF interaction site [polypeptide binding]; other site
640081007873	GTP/Mg2+ binding site [chemical binding]; other site
640081007874	Switch I region; other site
640081007875	G2 box; other site
640081007876	G3 box; other site
640081007877	Switch II region; other site
640081007878	G4 box; other site
640081007879	G5 box; other site
640081007880	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
640081007881	PAS fold; Region: PAS_4; pfam08448
640081007882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007883	putative active site [active]
640081007884	heme pocket [chemical binding]; other site
640081007885	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007886	PAS domain; Region: PAS_9; pfam13426
640081007887	putative active site [active]
640081007888	heme pocket [chemical binding]; other site
640081007889	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081007890	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081007891	metal binding site [ion binding]; metal-binding site
640081007892	active site
640081007893	I-site; other site
640081007894	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081007895	hypothetical protein; Provisional; Region: PRK01254
640081007896	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
640081007897	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
640081007898	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
640081007899	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081007900	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
640081007901	apolar tunnel; other site
640081007902	heme binding site [chemical binding]; other site
640081007903	dimerization interface [polypeptide binding]; other site
640081007904	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
640081007905	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
640081007906	G1 box; other site
640081007907	putative GEF interaction site [polypeptide binding]; other site
640081007908	GTP/Mg2+ binding site [chemical binding]; other site
640081007909	Switch I region; other site
640081007910	G2 box; other site
640081007911	G3 box; other site
640081007912	Switch II region; other site
640081007913	G4 box; other site
640081007914	G5 box; other site
640081007915	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
640081007916	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
640081007917	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081007918	PAS fold; Region: PAS_3; pfam08447
640081007919	putative active site [active]
640081007920	heme pocket [chemical binding]; other site
640081007921	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081007922	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081007923	metal binding site [ion binding]; metal-binding site
640081007924	active site
640081007925	I-site; other site
640081007926	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081007927	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
640081007928	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
640081007929	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081007930	FeS/SAM binding site; other site
640081007931	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
640081007932	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081007933	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081007934	ligand binding site [chemical binding]; other site
640081007935	flexible hinge region; other site
640081007936	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
640081007937	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
640081007938	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
640081007939	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081007940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081007941	homodimer interface [polypeptide binding]; other site
640081007942	catalytic residue [active]
640081007943	excinuclease ABC subunit B; Provisional; Region: PRK05298
640081007944	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
640081007945	ATP binding site [chemical binding]; other site
640081007946	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
640081007947	nucleotide binding region [chemical binding]; other site
640081007948	ATP-binding site [chemical binding]; other site
640081007949	Ultra-violet resistance protein B; Region: UvrB; pfam12344
640081007950	UvrB/uvrC motif; Region: UVR; pfam02151
640081007951	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
640081007952	Low molecular weight phosphatase family; Region: LMWPc; cd00115
640081007953	active site
640081007954	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
640081007955	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
640081007956	homodimer interface [polypeptide binding]; other site
640081007957	oligonucleotide binding site [chemical binding]; other site
640081007958	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
640081007959	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
640081007960	RNA binding surface [nucleotide binding]; other site
640081007961	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
640081007962	active site
640081007963	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
640081007964	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
640081007965	motif II; other site
640081007966	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
640081007967	iron-sulfur cluster [ion binding]; other site
640081007968	[2Fe-2S] cluster binding site [ion binding]; other site
640081007969	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
640081007970	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
640081007971	tandem repeat interface [polypeptide binding]; other site
640081007972	oligomer interface [polypeptide binding]; other site
640081007973	active site residues [active]
640081007974	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
640081007975	putative SAM binding site [chemical binding]; other site
640081007976	homodimer interface [polypeptide binding]; other site
640081007977	Maf-like protein; Region: Maf; pfam02545
640081007978	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
640081007979	active site
640081007980	dimer interface [polypeptide binding]; other site
640081007981	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
640081007982	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
640081007983	putative phosphate acyltransferase; Provisional; Region: PRK05331
640081007984	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
640081007985	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
640081007986	dimer interface [polypeptide binding]; other site
640081007987	active site
640081007988	CoA binding pocket [chemical binding]; other site
640081007989	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
640081007990	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
640081007991	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
640081007992	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
640081007993	NAD(P) binding site [chemical binding]; other site
640081007994	homotetramer interface [polypeptide binding]; other site
640081007995	homodimer interface [polypeptide binding]; other site
640081007996	active site
640081007997	acyl carrier protein; Provisional; Region: acpP; PRK00982
640081007998	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
640081007999	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
640081008000	dimer interface [polypeptide binding]; other site
640081008001	active site
640081008002	L-aspartate oxidase; Provisional; Region: PRK09077
640081008003	L-aspartate oxidase; Provisional; Region: PRK06175
640081008004	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
640081008005	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
640081008006	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081008007	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081008008	DNA binding residues [nucleotide binding]
640081008009	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
640081008010	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
640081008011	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
640081008012	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
640081008013	protein binding site [polypeptide binding]; other site
640081008014	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
640081008015	protein binding site [polypeptide binding]; other site
640081008016	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
640081008017	GTP-binding protein LepA; Provisional; Region: PRK05433
640081008018	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
640081008019	G1 box; other site
640081008020	putative GEF interaction site [polypeptide binding]; other site
640081008021	GTP/Mg2+ binding site [chemical binding]; other site
640081008022	Switch I region; other site
640081008023	G2 box; other site
640081008024	G3 box; other site
640081008025	Switch II region; other site
640081008026	G4 box; other site
640081008027	G5 box; other site
640081008028	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
640081008029	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
640081008030	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
640081008031	signal peptidase I; Provisional; Region: PRK10861
640081008032	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
640081008033	Catalytic site [active]
640081008034	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
640081008035	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
640081008036	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
640081008037	dimerization interface [polypeptide binding]; other site
640081008038	active site
640081008039	metal binding site [ion binding]; metal-binding site
640081008040	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
640081008041	GTPase Era; Reviewed; Region: era; PRK00089
640081008042	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
640081008043	G1 box; other site
640081008044	GTP/Mg2+ binding site [chemical binding]; other site
640081008045	Switch I region; other site
640081008046	G2 box; other site
640081008047	Switch II region; other site
640081008048	G3 box; other site
640081008049	G4 box; other site
640081008050	G5 box; other site
640081008051	KH domain; Region: KH_2; pfam07650
640081008052	Recombination protein O N terminal; Region: RecO_N; pfam11967
640081008053	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
640081008054	Recombination protein O C terminal; Region: RecO_C; pfam02565
640081008055	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
640081008056	active site
640081008057	hydrophilic channel; other site
640081008058	dimerization interface [polypeptide binding]; other site
640081008059	catalytic residues [active]
640081008060	active site lid [active]
640081008061	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
640081008062	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
640081008063	beta-hexosaminidase; Provisional; Region: PRK05337
640081008064	DNA ligase; Provisional; Region: PRK09125
640081008065	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
640081008066	DNA binding site [nucleotide binding]
640081008067	active site
640081008068	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
640081008069	DNA binding site [nucleotide binding]
640081008070	elongation factor P; Validated; Region: PRK00529
640081008071	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
640081008072	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
640081008073	RNA binding site [nucleotide binding]; other site
640081008074	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
640081008075	RNA binding site [nucleotide binding]; other site
640081008076	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
640081008077	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
640081008078	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
640081008079	Fe-S cluster binding site [ion binding]; other site
640081008080	DNA binding site [nucleotide binding]
640081008081	active site
640081008082	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
640081008083	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
640081008084	GIY-YIG motif/motif A; other site
640081008085	active site
640081008086	catalytic site [active]
640081008087	putative DNA binding site [nucleotide binding]; other site
640081008088	metal binding site [ion binding]; metal-binding site
640081008089	UvrB/uvrC motif; Region: UVR; pfam02151
640081008090	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
640081008091	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
640081008092	Protein of unknown function (DUF1178); Region: DUF1178; cl17833
640081008093	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
640081008094	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
640081008095	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
640081008096	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
640081008097	active site
640081008098	catalytic site [active]
640081008099	substrate binding site [chemical binding]; other site
640081008100	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
640081008101	RNA/DNA hybrid binding site [nucleotide binding]; other site
640081008102	active site
640081008103	Methyltransferase domain; Region: Methyltransf_11; pfam08241
640081008104	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
640081008105	Response regulator receiver domain; Region: Response_reg; pfam00072
640081008106	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081008107	active site
640081008108	phosphorylation site [posttranslational modification]
640081008109	intermolecular recognition site; other site
640081008110	dimerization interface [polypeptide binding]; other site
640081008111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081008112	Response regulator receiver domain; Region: Response_reg; pfam00072
640081008113	active site
640081008114	phosphorylation site [posttranslational modification]
640081008115	intermolecular recognition site; other site
640081008116	dimerization interface [polypeptide binding]; other site
640081008117	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081008118	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081008119	metal binding site [ion binding]; metal-binding site
640081008120	active site
640081008121	I-site; other site
640081008122	RmuC family; Region: RmuC; pfam02646
640081008123	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
640081008124	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
640081008125	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
640081008126	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
640081008127	Catalytic domain of Protein Kinases; Region: PKc; cd00180
640081008128	active site
640081008129	ATP binding site [chemical binding]; other site
640081008130	substrate binding site [chemical binding]; other site
640081008131	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
640081008132	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
640081008133	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
640081008134	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
640081008135	catalytic residues [active]
640081008136	catalytic nucleophile [active]
640081008137	Presynaptic Site I dimer interface [polypeptide binding]; other site
640081008138	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
640081008139	Synaptic Flat tetramer interface [polypeptide binding]; other site
640081008140	Synaptic Site I dimer interface [polypeptide binding]; other site
640081008141	DNA binding site [nucleotide binding]
640081008142	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
640081008143	putative transcriptional regulator MerR; Provisional; Region: PRK13752
640081008144	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
640081008145	DNA binding residues [nucleotide binding]
640081008146	dimer interface [polypeptide binding]; other site
640081008147	mercury binding site [ion binding]; other site
640081008148	putative mercuric transport protein; Provisional; Region: PRK13751
640081008149	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
640081008150	metal-binding site [ion binding]
640081008151	Membrane transport protein MerF; Region: Transport_MerF; pfam11431
640081008152	putative mercuric reductase; Provisional; Region: PRK13748
640081008153	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
640081008154	metal-binding site [ion binding]
640081008155	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
640081008156	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
640081008157	transcriptional regulator MerD; Provisional; Region: PRK13749
640081008158	Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111
640081008159	DNA binding residues [nucleotide binding]
640081008160	putative dimer interface [polypeptide binding]; other site
640081008161	putative mercury resistance protein; Provisional; Region: PRK13747
640081008162	multiple promoter invertase; Provisional; Region: mpi; PRK13413
640081008163	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
640081008164	catalytic residues [active]
640081008165	catalytic nucleophile [active]
640081008166	Presynaptic Site I dimer interface [polypeptide binding]; other site
640081008167	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
640081008168	Synaptic Flat tetramer interface [polypeptide binding]; other site
640081008169	Synaptic Site I dimer interface [polypeptide binding]; other site
640081008170	DNA binding site [nucleotide binding]
640081008171	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
640081008172	DNA-binding interface [nucleotide binding]; DNA binding site
640081008173	TniQ; Region: TniQ; pfam06527
640081008174	Bacterial TniB protein; Region: TniB; pfam05621
640081008175	Integrase core domain; Region: rve; pfam00665
640081008176	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
640081008177	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
640081008178	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
640081008179	non-specific DNA binding site [nucleotide binding]; other site
640081008180	salt bridge; other site
640081008181	sequence-specific DNA binding site [nucleotide binding]; other site
640081008182	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
640081008183	Helix-turn-helix domain; Region: HTH_38; pfam13936
640081008184	Homeodomain-like domain; Region: HTH_32; pfam13565
640081008185	Integrase core domain; Region: rve; pfam00665
640081008186	tetrathionate reductase subunit B; Provisional; Region: PRK14993
640081008187	4Fe-4S binding domain; Region: Fer4; pfam00037
640081008188	tetrathionate reductase subunit C; Provisional; Region: PRK14992
640081008189	tetrathionate reductase subunit A; Provisional; Region: PRK14991
640081008190	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
640081008191	molybdopterin cofactor binding site; other site
640081008192	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
640081008193	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
640081008194	putative molybdopterin cofactor binding site; other site
640081008195	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
640081008196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081008197	active site
640081008198	phosphorylation site [posttranslational modification]
640081008199	intermolecular recognition site; other site
640081008200	dimerization interface [polypeptide binding]; other site
640081008201	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
640081008202	DNA binding residues [nucleotide binding]
640081008203	dimerization interface [polypeptide binding]; other site
640081008204	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
640081008205	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081008206	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081008207	dimer interface [polypeptide binding]; other site
640081008208	phosphorylation site [posttranslational modification]
640081008209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081008210	ATP binding site [chemical binding]; other site
640081008211	Mg2+ binding site [ion binding]; other site
640081008212	G-X-G motif; other site
640081008213	MgtC family; Region: MgtC; pfam02308
640081008214	Predicted membrane protein [Function unknown]; Region: COG3174
640081008215	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
640081008216	Transposase; Region: DEDD_Tnp_IS110; pfam01548
640081008217	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
640081008218	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
640081008219	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
640081008220	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081008221	dimer interface [polypeptide binding]; other site
640081008222	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
640081008223	putative CheW interface [polypeptide binding]; other site
640081008224	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
640081008225	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
640081008226	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
640081008227	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
640081008228	dimer interface [polypeptide binding]; other site
640081008229	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081008230	catalytic residue [active]
640081008231	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
640081008232	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
640081008233	non-specific DNA binding site [nucleotide binding]; other site
640081008234	salt bridge; other site
640081008235	sequence-specific DNA binding site [nucleotide binding]; other site
640081008236	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
640081008237	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
640081008238	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
640081008239	catalytic residues [active]
640081008240	catalytic nucleophile [active]
640081008241	Presynaptic Site I dimer interface [polypeptide binding]; other site
640081008242	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
640081008243	Synaptic Flat tetramer interface [polypeptide binding]; other site
640081008244	Synaptic Site I dimer interface [polypeptide binding]; other site
640081008245	DNA binding site [nucleotide binding]
640081008246	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
640081008247	DNA-binding interface [nucleotide binding]; DNA binding site
640081008248	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
640081008249	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
640081008250	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
640081008251	activation loop (A-loop); other site
640081008252	HDOD domain; Region: HDOD; pfam08668
640081008253	GAF domain; Region: GAF_3; pfam13492
640081008254	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
640081008255	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081008256	binding surface
640081008257	TPR motif; other site
640081008258	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
640081008259	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
640081008260	RNA binding surface [nucleotide binding]; other site
640081008261	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
640081008262	active site
640081008263	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
640081008264	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
640081008265	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
640081008266	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
640081008267	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
640081008268	DctM-like transporters; Region: DctM; pfam06808
640081008269	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
640081008270	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
640081008271	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
640081008272	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
640081008273	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
640081008274	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
640081008275	homotetramer interface [polypeptide binding]; other site
640081008276	NAD(P) binding site [chemical binding]; other site
640081008277	homodimer interface [polypeptide binding]; other site
640081008278	active site
640081008279	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
640081008280	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
640081008281	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
640081008282	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
640081008283	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
640081008284	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
640081008285	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
640081008286	FeS/SAM binding site; other site
640081008287	hypothetical protein; Provisional; Region: PRK10279
640081008288	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
640081008289	active site
640081008290	nucleophile elbow; other site
640081008291	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
640081008292	FAD binding domain; Region: FAD_binding_4; pfam01565
640081008293	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
640081008294	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
640081008295	dimerization interface [polypeptide binding]; other site
640081008296	domain crossover interface; other site
640081008297	redox-dependent activation switch; other site
640081008298	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
640081008299	ArsC family; Region: ArsC; pfam03960
640081008300	putative catalytic residues [active]
640081008301	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
640081008302	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
640081008303	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
640081008304	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
640081008305	RNA binding site [nucleotide binding]; other site
640081008306	Cache domain; Region: Cache_1; pfam02743
640081008307	PAS fold; Region: PAS_4; pfam08448
640081008308	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081008309	putative active site [active]
640081008310	heme pocket [chemical binding]; other site
640081008311	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081008312	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081008313	metal binding site [ion binding]; metal-binding site
640081008314	active site
640081008315	I-site; other site
640081008316	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081008317	FliW protein; Region: FliW; cl00740
640081008318	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
640081008319	Helix-destabilising protein; Region: Phage_DNA_bind; pfam02303
640081008320	Phage replication protein CRI; Region: Phage_CRI; pfam05144
640081008321	Phage X family; Region: Phage_X; cl11585
640081008322	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
640081008323	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
640081008324	Integrase core domain; Region: rve; pfam00665
640081008325	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
640081008326	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081008327	Walker A motif; other site
640081008328	ATP binding site [chemical binding]; other site
640081008329	Walker B motif; other site
640081008330	arginine finger; other site
640081008331	Zonular occludens toxin (Zot); Region: Zot; cl17485
640081008332	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
640081008333	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
640081008334	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
640081008335	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
640081008336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
640081008337	LabA_like proteins; Region: LabA_like; cd06167
640081008338	Uncharacterized conserved protein [Function unknown]; Region: COG1432
640081008339	putative metal binding site [ion binding]; other site
640081008340	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
640081008341	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
640081008342	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
640081008343	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
640081008344	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
640081008345	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
640081008346	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
640081008347	Walker A motif; other site
640081008348	ATP binding site [chemical binding]; other site
640081008349	Walker B motif; other site
640081008350	Putative helicase; Region: TraI_2; pfam07514
640081008351	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
640081008352	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
640081008353	SprT homologues; Region: SprT; cl01182
640081008354	SprT-like family; Region: SprT-like; pfam10263
640081008355	VirB8 protein; Region: VirB8; cl01500
640081008356	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
640081008357	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
640081008358	VirB7 interaction site; other site
640081008359	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
640081008360	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
640081008361	VirB7 interaction site; other site
640081008362	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
640081008363	type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520
640081008364	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
640081008365	Walker A motif; other site
640081008366	ATP binding site [chemical binding]; other site
640081008367	Walker B motif; other site
640081008368	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
640081008369	PilS N terminal; Region: PilS; pfam08805
640081008370	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
640081008371	ATP binding site [chemical binding]; other site
640081008372	Walker B motif; other site
640081008373	Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917
640081008374	Methyltransferase domain; Region: Methyltransf_23; pfam13489
640081008375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081008376	S-adenosylmethionine binding site [chemical binding]; other site
640081008377	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
640081008378	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
640081008379	active site
640081008380	DNA binding site [nucleotide binding]
640081008381	Int/Topo IB signature motif; other site
640081008382	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
640081008383	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081008384	PAS domain; Region: PAS_9; pfam13426
640081008385	putative active site [active]
640081008386	heme pocket [chemical binding]; other site
640081008387	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081008388	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081008389	metal binding site [ion binding]; metal-binding site
640081008390	active site
640081008391	I-site; other site
640081008392	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081008393	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
640081008394	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
640081008395	N-acetyl-D-glucosamine binding site [chemical binding]; other site
640081008396	catalytic residue [active]
640081008397	DNA topoisomerase III; Provisional; Region: PRK07726
640081008398	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
640081008399	active site
640081008400	putative interdomain interaction site [polypeptide binding]; other site
640081008401	putative metal-binding site [ion binding]; other site
640081008402	putative nucleotide binding site [chemical binding]; other site
640081008403	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
640081008404	domain I; other site
640081008405	DNA binding groove [nucleotide binding]
640081008406	phosphate binding site [ion binding]; other site
640081008407	domain II; other site
640081008408	domain III; other site
640081008409	nucleotide binding site [chemical binding]; other site
640081008410	catalytic site [active]
640081008411	domain IV; other site
640081008412	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
640081008413	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
640081008414	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
640081008415	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
640081008416	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
640081008417	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
640081008418	dimer interface [polypeptide binding]; other site
640081008419	ssDNA binding site [nucleotide binding]; other site
640081008420	tetramer (dimer of dimers) interface [polypeptide binding]; other site
640081008421	Domain of unknown function (DUF1845); Region: DUF1845; cl07481
640081008422	recombination associated protein; Reviewed; Region: rdgC; PRK00321
640081008423	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
640081008424	non-specific DNA binding site [nucleotide binding]; other site
640081008425	salt bridge; other site
640081008426	sequence-specific DNA binding site [nucleotide binding]; other site
640081008427	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
640081008428	ParB-like nuclease domain; Region: ParBc; pfam02195
640081008429	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
640081008430	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
640081008431	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
640081008432	Magnesium ion binding site [ion binding]; other site
640081008433	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
640081008434	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
640081008435	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
640081008436	Int/Topo IB signature motif; other site
640081008437	UPF0489 domain; Region: UPF0489; pfam12640
640081008438	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
640081008439	Copper resistance protein K; Region: CopK; pfam11525
640081008440	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
640081008441	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081008442	Zn2+ binding site [ion binding]; other site
640081008443	Mg2+ binding site [ion binding]; other site
640081008444	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
640081008445	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
640081008446	Cytochrome c; Region: Cytochrom_C; pfam00034
640081008447	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
640081008448	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
640081008449	Trehalase; Region: Trehalase; cl17346
640081008450	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081008451	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
640081008452	Outer membrane efflux protein; Region: OEP; pfam02321
640081008453	Outer membrane efflux protein; Region: OEP; pfam02321
640081008454	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
640081008455	Protein of unknown function, DUF; Region: DUF411; cl01142
640081008456	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
640081008457	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
640081008458	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
640081008459	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
640081008460	Outer membrane efflux protein; Region: OEP; pfam02321
640081008461	Outer membrane efflux protein; Region: OEP; pfam02321
640081008462	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
640081008463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081008464	active site
640081008465	phosphorylation site [posttranslational modification]
640081008466	intermolecular recognition site; other site
640081008467	dimerization interface [polypeptide binding]; other site
640081008468	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081008469	DNA binding site [nucleotide binding]
640081008470	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
640081008471	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081008472	dimerization interface [polypeptide binding]; other site
640081008473	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081008474	dimer interface [polypeptide binding]; other site
640081008475	phosphorylation site [posttranslational modification]
640081008476	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081008477	ATP binding site [chemical binding]; other site
640081008478	Mg2+ binding site [ion binding]; other site
640081008479	G-X-G motif; other site
640081008480	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081008481	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
640081008482	Walker A motif; other site
640081008483	ATP binding site [chemical binding]; other site
640081008484	Walker B motif; other site
640081008485	arginine finger; other site
640081008486	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
640081008487	active site
640081008488	catalytic triad [active]
640081008489	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
640081008490	DNA binding site [nucleotide binding]
640081008491	dimer interface [polypeptide binding]; other site
640081008492	active site
640081008493	Int/Topo IB signature motif; other site
640081008494	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
640081008495	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
640081008496	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
640081008497	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
640081008498	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
640081008499	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
640081008500	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
640081008501	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
640081008502	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
640081008503	active site
640081008504	PilZ domain; Region: PilZ; cl01260
640081008505	DNA polymerase III subunit delta'; Validated; Region: PRK06964
640081008506	DNA polymerase III subunit delta'; Validated; Region: PRK08485
640081008507	thymidylate kinase; Validated; Region: tmk; PRK00698
640081008508	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
640081008509	TMP-binding site; other site
640081008510	ATP-binding site [chemical binding]; other site
640081008511	YceG-like family; Region: YceG; pfam02618
640081008512	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
640081008513	dimerization interface [polypeptide binding]; other site
640081008514	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
640081008515	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
640081008516	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
640081008517	NRDE protein; Region: NRDE; pfam05742
640081008518	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
640081008519	DNA-binding site [nucleotide binding]; DNA binding site
640081008520	RNA-binding motif; other site
640081008521	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
640081008522	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
640081008523	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
640081008524	nucleoside/Zn binding site; other site
640081008525	dimer interface [polypeptide binding]; other site
640081008526	catalytic motif [active]
640081008527	Methyltransferase domain; Region: Methyltransf_32; pfam13679
640081008528	Methyltransferase domain; Region: Methyltransf_31; pfam13847
640081008529	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
640081008530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
640081008531	NAD(P) binding site [chemical binding]; other site
640081008532	active site
640081008533	Predicted transcriptional regulators [Transcription]; Region: COG1733
640081008534	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
640081008535	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
640081008536	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
640081008537	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
640081008538	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
640081008539	GMP synthase; Reviewed; Region: guaA; PRK00074
640081008540	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
640081008541	AMP/PPi binding site [chemical binding]; other site
640081008542	candidate oxyanion hole; other site
640081008543	catalytic triad [active]
640081008544	potential glutamine specificity residues [chemical binding]; other site
640081008545	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
640081008546	ATP Binding subdomain [chemical binding]; other site
640081008547	Ligand Binding sites [chemical binding]; other site
640081008548	Dimerization subdomain; other site
640081008549	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
640081008550	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
640081008551	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
640081008552	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
640081008553	active site
640081008554	hypothetical protein; Validated; Region: PRK01777
640081008555	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
640081008556	putative coenzyme Q binding site [chemical binding]; other site
640081008557	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
640081008558	SmpB-tmRNA interface; other site
640081008559	Predicted membrane protein [Function unknown]; Region: COG2860
640081008560	UPF0126 domain; Region: UPF0126; pfam03458
640081008561	phosphoenolpyruvate synthase; Validated; Region: PRK06464
640081008562	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
640081008563	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
640081008564	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
640081008565	PEP synthetase regulatory protein; Provisional; Region: PRK05339
640081008566	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
640081008567	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
640081008568	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
640081008569	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
640081008570	RNA/DNA hybrid binding site [nucleotide binding]; other site
640081008571	active site
640081008572	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
640081008573	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
640081008574	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
640081008575	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
640081008576	active site
640081008577	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
640081008578	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
640081008579	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
640081008580	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
640081008581	trimer interface [polypeptide binding]; other site
640081008582	active site
640081008583	UDP-GlcNAc binding site [chemical binding]; other site
640081008584	lipid binding site [chemical binding]; lipid-binding site
640081008585	periplasmic chaperone; Provisional; Region: PRK10780
640081008586	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
640081008587	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
640081008588	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
640081008589	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
640081008590	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
640081008591	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
640081008592	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
640081008593	Surface antigen; Region: Bac_surface_Ag; pfam01103
640081008594	zinc metallopeptidase RseP; Provisional; Region: PRK10779
640081008595	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
640081008596	active site
640081008597	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
640081008598	protein binding site [polypeptide binding]; other site
640081008599	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
640081008600	protein binding site [polypeptide binding]; other site
640081008601	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
640081008602	putative substrate binding region [chemical binding]; other site
640081008603	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
640081008604	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
640081008605	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
640081008606	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
640081008607	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
640081008608	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
640081008609	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836
640081008610	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
640081008611	catalytic residue [active]
640081008612	putative FPP diphosphate  binding site; other site
640081008613	putative FPP binding hydrophobic cleft; other site
640081008614	dimer interface [polypeptide binding]; other site
640081008615	putative IPP diphosphate binding site; other site
640081008616	ribosome recycling factor; Reviewed; Region: frr; PRK00083
640081008617	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
640081008618	hinge region; other site
640081008619	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
640081008620	putative nucleotide binding site [chemical binding]; other site
640081008621	uridine monophosphate binding site [chemical binding]; other site
640081008622	homohexameric interface [polypeptide binding]; other site
640081008623	elongation factor Ts; Provisional; Region: tsf; PRK09377
640081008624	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
640081008625	Elongation factor TS; Region: EF_TS; pfam00889
640081008626	Elongation factor TS; Region: EF_TS; pfam00889
640081008627	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
640081008628	rRNA interaction site [nucleotide binding]; other site
640081008629	S8 interaction site; other site
640081008630	putative laminin-1 binding site; other site
640081008631	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
640081008632	active site
640081008633	PII uridylyl-transferase; Provisional; Region: PRK03059
640081008634	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
640081008635	metal binding triad; other site
640081008636	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
640081008637	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081008638	Zn2+ binding site [ion binding]; other site
640081008639	Mg2+ binding site [ion binding]; other site
640081008640	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
640081008641	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
640081008642	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
640081008643	active site
640081008644	catalytic residues [active]
640081008645	metal binding site [ion binding]; metal-binding site
640081008646	5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136
640081008647	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
640081008648	active site
640081008649	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
640081008650	active site
640081008651	tetramer interface; other site
640081008652	Ligase N family; Region: LIGANc; smart00532
640081008653	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
640081008654	nucleotide binding pocket [chemical binding]; other site
640081008655	K-X-D-G motif; other site
640081008656	catalytic site [active]
640081008657	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
640081008658	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
640081008659	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
640081008660	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
640081008661	Dimer interface [polypeptide binding]; other site
640081008662	ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771
640081008663	FtsZ protein binding site [polypeptide binding]; other site
640081008664	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
640081008665	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
640081008666	Walker A/P-loop; other site
640081008667	ATP binding site [chemical binding]; other site
640081008668	Q-loop/lid; other site
640081008669	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
640081008670	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
640081008671	Q-loop/lid; other site
640081008672	ABC transporter signature motif; other site
640081008673	Walker B; other site
640081008674	D-loop; other site
640081008675	H-loop/switch region; other site
640081008676	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
640081008677	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
640081008678	SEC-C motif; Region: SEC-C; pfam02810
640081008679	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
640081008680	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
640081008681	active site
640081008682	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
640081008683	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
640081008684	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081008685	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081008686	homodimer interface [polypeptide binding]; other site
640081008687	catalytic residue [active]
640081008688	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
640081008689	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
640081008690	trimer interface [polypeptide binding]; other site
640081008691	active site
640081008692	substrate binding site [chemical binding]; other site
640081008693	CoA binding site [chemical binding]; other site
640081008694	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
640081008695	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
640081008696	Walker A motif; other site
640081008697	ATP binding site [chemical binding]; other site
640081008698	Walker B motif; other site
640081008699	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
640081008700	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
640081008701	metal binding site [ion binding]; metal-binding site
640081008702	dimer interface [polypeptide binding]; other site
640081008703	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
640081008704	capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689
640081008705	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081008706	S-adenosylmethionine binding site [chemical binding]; other site
640081008707	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
640081008708	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
640081008709	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
640081008710	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
640081008711	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
640081008712	RNase E interface [polypeptide binding]; other site
640081008713	trimer interface [polypeptide binding]; other site
640081008714	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
640081008715	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
640081008716	RNase E interface [polypeptide binding]; other site
640081008717	trimer interface [polypeptide binding]; other site
640081008718	active site
640081008719	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
640081008720	putative nucleic acid binding region [nucleotide binding]; other site
640081008721	G-X-X-G motif; other site
640081008722	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
640081008723	RNA binding site [nucleotide binding]; other site
640081008724	domain interface; other site
640081008725	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
640081008726	16S/18S rRNA binding site [nucleotide binding]; other site
640081008727	S13e-L30e interaction site [polypeptide binding]; other site
640081008728	25S rRNA binding site [nucleotide binding]; other site
640081008729	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
640081008730	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
640081008731	RNA binding site [nucleotide binding]; other site
640081008732	active site
640081008733	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
640081008734	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
640081008735	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
640081008736	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
640081008737	translation initiation factor IF-2; Region: IF-2; TIGR00487
640081008738	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
640081008739	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
640081008740	G1 box; other site
640081008741	putative GEF interaction site [polypeptide binding]; other site
640081008742	GTP/Mg2+ binding site [chemical binding]; other site
640081008743	Switch I region; other site
640081008744	G2 box; other site
640081008745	G3 box; other site
640081008746	Switch II region; other site
640081008747	G4 box; other site
640081008748	G5 box; other site
640081008749	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
640081008750	Translation-initiation factor 2; Region: IF-2; pfam11987
640081008751	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
640081008752	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
640081008753	NusA N-terminal domain; Region: NusA_N; pfam08529
640081008754	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
640081008755	RNA binding site [nucleotide binding]; other site
640081008756	homodimer interface [polypeptide binding]; other site
640081008757	NusA-like KH domain; Region: KH_5; pfam13184
640081008758	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
640081008759	G-X-X-G motif; other site
640081008760	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
640081008761	ribosome maturation protein RimP; Reviewed; Region: PRK00092
640081008762	Sm and related proteins; Region: Sm_like; cl00259
640081008763	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
640081008764	putative oligomer interface [polypeptide binding]; other site
640081008765	putative RNA binding site [nucleotide binding]; other site
640081008766	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
640081008767	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
640081008768	RNA binding surface [nucleotide binding]; other site
640081008769	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
640081008770	probable active site [active]
640081008771	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
640081008772	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
640081008773	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
640081008774	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
640081008775	active site
640081008776	HIGH motif; other site
640081008777	dimer interface [polypeptide binding]; other site
640081008778	KMSKS motif; other site
640081008779	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
640081008780	active site
640081008781	putative substrate binding region [chemical binding]; other site
640081008782	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
640081008783	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
640081008784	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
640081008785	active site
640081008786	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
640081008787	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
640081008788	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
640081008789	PGAP1-like protein; Region: PGAP1; pfam07819
640081008790	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
640081008791	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
640081008792	heme binding site [chemical binding]; other site
640081008793	ferroxidase pore; other site
640081008794	ferroxidase diiron center [ion binding]; other site
640081008795	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
640081008796	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
640081008797	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
640081008798	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
640081008799	lipoyl attachment site [posttranslational modification]; other site
640081008800	glycine dehydrogenase; Provisional; Region: PRK05367
640081008801	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
640081008802	tetramer interface [polypeptide binding]; other site
640081008803	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081008804	catalytic residue [active]
640081008805	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
640081008806	tetramer interface [polypeptide binding]; other site
640081008807	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081008808	catalytic residue [active]
640081008809	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
640081008810	ACT domain; Region: ACT_6; pfam13740
640081008811	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
640081008812	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
640081008813	E3 interaction surface; other site
640081008814	lipoyl attachment site [posttranslational modification]; other site
640081008815	Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955
640081008816	PAS domain; Region: PAS_9; pfam13426
640081008817	putative chaperone; Provisional; Region: PRK11678
640081008818	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
640081008819	nucleotide binding site [chemical binding]; other site
640081008820	putative NEF/HSP70 interaction site [polypeptide binding]; other site
640081008821	SBD interface [polypeptide binding]; other site
640081008822	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
640081008823	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
640081008824	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
640081008825	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081008826	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081008827	dimer interface [polypeptide binding]; other site
640081008828	putative CheW interface [polypeptide binding]; other site
640081008829	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
640081008830	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081008831	Walker A/P-loop; other site
640081008832	ATP binding site [chemical binding]; other site
640081008833	Q-loop/lid; other site
640081008834	ABC transporter signature motif; other site
640081008835	Walker B; other site
640081008836	D-loop; other site
640081008837	H-loop/switch region; other site
640081008838	ABC transporter; Region: ABC_tran_2; pfam12848
640081008839	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
640081008840	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
640081008841	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
640081008842	cyanophycin synthetase; Provisional; Region: PRK14016
640081008843	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
640081008844	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
640081008845	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
640081008846	cyanophycin synthetase; Provisional; Region: PRK14016
640081008847	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
640081008848	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
640081008849	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
640081008850	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
640081008851	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
640081008852	Walker A/P-loop; other site
640081008853	ATP binding site [chemical binding]; other site
640081008854	Q-loop/lid; other site
640081008855	ABC transporter signature motif; other site
640081008856	Walker B; other site
640081008857	D-loop; other site
640081008858	H-loop/switch region; other site
640081008859	Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
640081008860	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
640081008861	Peptidase family U32; Region: Peptidase_U32; pfam01136
640081008862	Collagenase; Region: DUF3656; pfam12392
640081008863	SlyX; Region: SlyX; pfam04102
640081008864	Uncharacterized conserved protein [Function unknown]; Region: COG1284
640081008865	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
640081008866	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081008867	S-adenosylmethionine binding site [chemical binding]; other site
640081008868	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
640081008869	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
640081008870	putative RNA binding site [nucleotide binding]; other site
640081008871	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
640081008872	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
640081008873	RNA binding surface [nucleotide binding]; other site
640081008874	Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555
640081008875	active site
640081008876	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
640081008877	rRNA binding site [nucleotide binding]; other site
640081008878	predicted 30S ribosome binding site; other site
640081008879	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
640081008880	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
640081008881	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
640081008882	GTP/Mg2+ binding site [chemical binding]; other site
640081008883	G4 box; other site
640081008884	G5 box; other site
640081008885	G1 box; other site
640081008886	Switch I region; other site
640081008887	G2 box; other site
640081008888	G3 box; other site
640081008889	Switch II region; other site
640081008890	MgtC family; Region: MgtC; pfam02308
640081008891	serine/threonine protein kinase; Provisional; Region: PRK11768
640081008892	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
640081008893	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
640081008894	catalytic residues [active]
640081008895	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
640081008896	MG2 domain; Region: A2M_N; pfam01835
640081008897	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
640081008898	Alpha-2-macroglobulin family; Region: A2M; pfam00207
640081008899	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
640081008900	Transglycosylase; Region: Transgly; pfam00912
640081008901	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
640081008902	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
640081008903	YaeQ protein; Region: YaeQ; pfam07152
640081008904	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
640081008905	Protein of unknown function, DUF479; Region: DUF479; cl01203
640081008906	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
640081008907	homodimer interface [polypeptide binding]; other site
640081008908	chemical substrate binding site [chemical binding]; other site
640081008909	oligomer interface [polypeptide binding]; other site
640081008910	metal binding site [ion binding]; metal-binding site
640081008911	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
640081008912	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
640081008913	metal binding site [ion binding]; metal-binding site
640081008914	dimer interface [polypeptide binding]; other site
640081008915	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
640081008916	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
640081008917	trimer interface [polypeptide binding]; other site
640081008918	putative metal binding site [ion binding]; other site
640081008919	CHASE domain; Region: CHASE; pfam03924
640081008920	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
640081008921	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081008922	PAS fold; Region: PAS_3; pfam08447
640081008923	putative active site [active]
640081008924	heme pocket [chemical binding]; other site
640081008925	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081008926	PAS fold; Region: PAS_3; pfam08447
640081008927	putative active site [active]
640081008928	heme pocket [chemical binding]; other site
640081008929	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081008930	dimer interface [polypeptide binding]; other site
640081008931	phosphorylation site [posttranslational modification]
640081008932	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081008933	ATP binding site [chemical binding]; other site
640081008934	Mg2+ binding site [ion binding]; other site
640081008935	G-X-G motif; other site
640081008936	Response regulator receiver domain; Region: Response_reg; pfam00072
640081008937	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081008938	active site
640081008939	phosphorylation site [posttranslational modification]
640081008940	intermolecular recognition site; other site
640081008941	dimerization interface [polypeptide binding]; other site
640081008942	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
640081008943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081008944	active site
640081008945	phosphorylation site [posttranslational modification]
640081008946	intermolecular recognition site; other site
640081008947	dimerization interface [polypeptide binding]; other site
640081008948	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081008949	PAS fold; Region: PAS_3; pfam08447
640081008950	putative active site [active]
640081008951	heme pocket [chemical binding]; other site
640081008952	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081008953	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
640081008954	putative active site [active]
640081008955	heme pocket [chemical binding]; other site
640081008956	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081008957	putative active site [active]
640081008958	heme pocket [chemical binding]; other site
640081008959	PAS fold; Region: PAS_3; pfam08447
640081008960	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081008961	dimer interface [polypeptide binding]; other site
640081008962	phosphorylation site [posttranslational modification]
640081008963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081008964	ATP binding site [chemical binding]; other site
640081008965	Mg2+ binding site [ion binding]; other site
640081008966	G-X-G motif; other site
640081008967	Response regulator receiver domain; Region: Response_reg; pfam00072
640081008968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081008969	active site
640081008970	phosphorylation site [posttranslational modification]
640081008971	intermolecular recognition site; other site
640081008972	dimerization interface [polypeptide binding]; other site
640081008973	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
640081008974	putative binding surface; other site
640081008975	active site
640081008976	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
640081008977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081008978	active site
640081008979	phosphorylation site [posttranslational modification]
640081008980	intermolecular recognition site; other site
640081008981	dimerization interface [polypeptide binding]; other site
640081008982	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081008983	Zn2+ binding site [ion binding]; other site
640081008984	Mg2+ binding site [ion binding]; other site
640081008985	Response regulator receiver domain; Region: Response_reg; pfam00072
640081008986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081008987	active site
640081008988	phosphorylation site [posttranslational modification]
640081008989	intermolecular recognition site; other site
640081008990	dimerization interface [polypeptide binding]; other site
640081008991	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
640081008992	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
640081008993	CAP-like domain; other site
640081008994	active site
640081008995	primary dimer interface [polypeptide binding]; other site
640081008996	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
640081008997	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
640081008998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081008999	ATP binding site [chemical binding]; other site
640081009000	Mg2+ binding site [ion binding]; other site
640081009001	G-X-G motif; other site
640081009002	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
640081009003	anchoring element; other site
640081009004	dimer interface [polypeptide binding]; other site
640081009005	ATP binding site [chemical binding]; other site
640081009006	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
640081009007	active site
640081009008	putative metal-binding site [ion binding]; other site
640081009009	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
640081009010	Transglycosylase; Region: Transgly; pfam00912
640081009011	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
640081009012	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
640081009013	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
640081009014	active site
640081009015	HIGH motif; other site
640081009016	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
640081009017	active site
640081009018	KMSKS motif; other site
640081009019	NAD-dependent deacetylase; Provisional; Region: PRK00481
640081009020	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
640081009021	NAD+ binding site [chemical binding]; other site
640081009022	substrate binding site [chemical binding]; other site
640081009023	Zn binding site [ion binding]; other site
640081009024	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
640081009025	N-acetyl-D-glucosamine binding site [chemical binding]; other site
640081009026	catalytic residue [active]
640081009027	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
640081009028	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
640081009029	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
640081009030	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
640081009031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
640081009032	putative substrate translocation pore; other site
640081009033	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
640081009034	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
640081009035	Walker A/P-loop; other site
640081009036	ATP binding site [chemical binding]; other site
640081009037	Q-loop/lid; other site
640081009038	ABC transporter signature motif; other site
640081009039	Walker B; other site
640081009040	D-loop; other site
640081009041	H-loop/switch region; other site
640081009042	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
640081009043	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
640081009044	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
640081009045	Walker A/P-loop; other site
640081009046	ATP binding site [chemical binding]; other site
640081009047	Q-loop/lid; other site
640081009048	ABC transporter signature motif; other site
640081009049	Walker B; other site
640081009050	D-loop; other site
640081009051	H-loop/switch region; other site
640081009052	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
640081009053	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
640081009054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081009055	dimer interface [polypeptide binding]; other site
640081009056	conserved gate region; other site
640081009057	putative PBP binding loops; other site
640081009058	ABC-ATPase subunit interface; other site
640081009059	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
640081009060	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081009061	dimer interface [polypeptide binding]; other site
640081009062	putative PBP binding loops; other site
640081009063	ABC-ATPase subunit interface; other site
640081009064	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
640081009065	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
640081009066	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
640081009067	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081009068	dimerization interface [polypeptide binding]; other site
640081009069	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081009070	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081009071	metal binding site [ion binding]; metal-binding site
640081009072	active site
640081009073	I-site; other site
640081009074	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
640081009075	PAS domain S-box; Region: sensory_box; TIGR00229
640081009076	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081009077	putative active site [active]
640081009078	heme pocket [chemical binding]; other site
640081009079	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081009080	PAS domain; Region: PAS_9; pfam13426
640081009081	putative active site [active]
640081009082	heme pocket [chemical binding]; other site
640081009083	PAS domain S-box; Region: sensory_box; TIGR00229
640081009084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081009085	putative active site [active]
640081009086	heme pocket [chemical binding]; other site
640081009087	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081009088	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081009089	ATP binding site [chemical binding]; other site
640081009090	Mg2+ binding site [ion binding]; other site
640081009091	G-X-G motif; other site
640081009092	enoyl-CoA hydratase; Validated; Region: PRK08139
640081009093	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
640081009094	substrate binding site [chemical binding]; other site
640081009095	oxyanion hole (OAH) forming residues; other site
640081009096	trimer interface [polypeptide binding]; other site
640081009097	acyl-CoA synthetase; Validated; Region: PRK08162
640081009098	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
640081009099	acyl-activating enzyme (AAE) consensus motif; other site
640081009100	putative active site [active]
640081009101	AMP binding site [chemical binding]; other site
640081009102	putative CoA binding site [chemical binding]; other site
640081009103	Protein of unknown function (DUF330); Region: DUF330; cl01135
640081009104	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
640081009105	mce related protein; Region: MCE; pfam02470
640081009106	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
640081009107	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081009108	Walker A/P-loop; other site
640081009109	ATP binding site [chemical binding]; other site
640081009110	Q-loop/lid; other site
640081009111	ABC transporter signature motif; other site
640081009112	Walker B; other site
640081009113	D-loop; other site
640081009114	H-loop/switch region; other site
640081009115	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
640081009116	Permease; Region: Permease; pfam02405
640081009117	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
640081009118	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
640081009119	polyphosphate kinase; Provisional; Region: PRK05443
640081009120	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
640081009121	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
640081009122	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
640081009123	putative domain interface [polypeptide binding]; other site
640081009124	putative active site [active]
640081009125	catalytic site [active]
640081009126	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
640081009127	putative domain interface [polypeptide binding]; other site
640081009128	putative active site [active]
640081009129	catalytic site [active]
640081009130	Predicted flavoprotein [General function prediction only]; Region: COG0431
640081009131	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
640081009132	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
640081009133	HD domain; Region: HD_4; pfam13328
640081009134	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
640081009135	synthetase active site [active]
640081009136	NTP binding site [chemical binding]; other site
640081009137	metal binding site [ion binding]; metal-binding site
640081009138	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
640081009139	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
640081009140	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
640081009141	EamA-like transporter family; Region: EamA; pfam00892
640081009142	EamA-like transporter family; Region: EamA; pfam00892
640081009143	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
640081009144	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
640081009145	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
640081009146	catalytic site [active]
640081009147	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
640081009148	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
640081009149	Ion channel; Region: Ion_trans_2; pfam07885
640081009150	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
640081009151	TrkA-N domain; Region: TrkA_N; pfam02254
640081009152	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
640081009153	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
640081009154	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
640081009155	Competence protein; Region: Competence; pfam03772
640081009156	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
640081009157	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
640081009158	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
640081009159	DNA methylase; Region: N6_N4_Mtase; cl17433
640081009160	DNA methylase; Region: N6_N4_Mtase; pfam01555
640081009161	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
640081009162	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
640081009163	non-specific DNA binding site [nucleotide binding]; other site
640081009164	salt bridge; other site
640081009165	sequence-specific DNA binding site [nucleotide binding]; other site
640081009166	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
640081009167	His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977
640081009168	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081009169	FeS/SAM binding site; other site
640081009170	His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978
640081009171	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081009172	FeS/SAM binding site; other site
640081009173	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
640081009174	His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976
640081009175	TniQ; Region: TniQ; pfam06527
640081009176	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
640081009177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081009178	Walker A motif; other site
640081009179	ATP binding site [chemical binding]; other site
640081009180	Walker B motif; other site
640081009181	arginine finger; other site
640081009182	Bacterial TniB protein; Region: TniB; pfam05621
640081009183	AAA domain; Region: AAA_22; pfam13401
640081009184	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
640081009185	Integrase core domain; Region: rve; pfam00665
640081009186	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
640081009187	Flagellin N-methylase; Region: FliB; pfam03692
640081009188	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
640081009189	Walker A/P-loop; other site
640081009190	ATP binding site [chemical binding]; other site
640081009191	haemagglutination activity domain; Region: Haemagg_act; pfam05860
640081009192	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
640081009193	peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925
640081009194	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
640081009195	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
640081009196	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
640081009197	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
640081009198	Nitrate and nitrite sensing; Region: NIT; pfam08376
640081009199	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081009200	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081009201	dimerization interface [polypeptide binding]; other site
640081009202	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081009203	dimer interface [polypeptide binding]; other site
640081009204	putative CheW interface [polypeptide binding]; other site
640081009205	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
640081009206	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
640081009207	Walker A/P-loop; other site
640081009208	ATP binding site [chemical binding]; other site
640081009209	Q-loop/lid; other site
640081009210	ABC transporter signature motif; other site
640081009211	Walker B; other site
640081009212	D-loop; other site
640081009213	H-loop/switch region; other site
640081009214	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
640081009215	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
640081009216	FtsX-like permease family; Region: FtsX; pfam02687
640081009217	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
640081009218	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
640081009219	DHH family; Region: DHH; pfam01368
640081009220	DHHA1 domain; Region: DHHA1; pfam02272
640081009221	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
640081009222	peptide chain release factor 2; Validated; Region: prfB; PRK00578
640081009223	This domain is found in peptide chain release factors; Region: PCRF; smart00937
640081009224	RF-1 domain; Region: RF-1; pfam00472
640081009225	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
640081009226	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
640081009227	dimer interface [polypeptide binding]; other site
640081009228	putative anticodon binding site; other site
640081009229	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
640081009230	motif 1; other site
640081009231	active site
640081009232	motif 2; other site
640081009233	motif 3; other site
640081009234	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081009235	HAMP domain; Region: HAMP; pfam00672
640081009236	dimerization interface [polypeptide binding]; other site
640081009237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081009238	dimer interface [polypeptide binding]; other site
640081009239	phosphorylation site [posttranslational modification]
640081009240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081009241	ATP binding site [chemical binding]; other site
640081009242	Mg2+ binding site [ion binding]; other site
640081009243	G-X-G motif; other site
640081009244	Response regulator receiver domain; Region: Response_reg; pfam00072
640081009245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081009246	active site
640081009247	phosphorylation site [posttranslational modification]
640081009248	intermolecular recognition site; other site
640081009249	dimerization interface [polypeptide binding]; other site
640081009250	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
640081009251	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
640081009252	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081009253	N-terminal plug; other site
640081009254	ligand-binding site [chemical binding]; other site
640081009255	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
640081009256	Uncharacterized conserved protein [Function unknown]; Region: COG4121
640081009257	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
640081009258	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
640081009259	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081009260	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
640081009261	putative dimerization interface [polypeptide binding]; other site
640081009262	Domain of unknown function (DUF897); Region: DUF897; cl01312
640081009263	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
640081009264	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
640081009265	phosphopeptide binding site; other site
640081009266	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
640081009267	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
640081009268	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
640081009269	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
640081009270	catalytic triad [active]
640081009271	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
640081009272	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
640081009273	macrolide transporter subunit MacA; Provisional; Region: PRK11578
640081009274	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
640081009275	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081009276	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
640081009277	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
640081009278	Walker A/P-loop; other site
640081009279	ATP binding site [chemical binding]; other site
640081009280	Q-loop/lid; other site
640081009281	ABC transporter signature motif; other site
640081009282	Walker B; other site
640081009283	D-loop; other site
640081009284	H-loop/switch region; other site
640081009285	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
640081009286	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
640081009287	FtsX-like permease family; Region: FtsX; pfam02687
640081009288	Cache domain; Region: Cache_2; pfam08269
640081009289	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081009290	dimerization interface [polypeptide binding]; other site
640081009291	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081009292	dimer interface [polypeptide binding]; other site
640081009293	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
640081009294	putative CheW interface [polypeptide binding]; other site
640081009295	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
640081009296	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
640081009297	inhibitor-cofactor binding pocket; inhibition site
640081009298	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081009299	catalytic residue [active]
640081009300	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
640081009301	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
640081009302	substrate-cofactor binding pocket; other site
640081009303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081009304	catalytic residue [active]
640081009305	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
640081009306	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
640081009307	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081009308	S-adenosylmethionine binding site [chemical binding]; other site
640081009309	AAA domain; Region: AAA_26; pfam13500
640081009310	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
640081009311	PAS fold; Region: PAS; pfam00989
640081009312	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081009313	putative active site [active]
640081009314	heme pocket [chemical binding]; other site
640081009315	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
640081009316	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081009317	dimer interface [polypeptide binding]; other site
640081009318	phosphorylation site [posttranslational modification]
640081009319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081009320	ATP binding site [chemical binding]; other site
640081009321	Mg2+ binding site [ion binding]; other site
640081009322	G-X-G motif; other site
640081009323	Response regulator receiver domain; Region: Response_reg; pfam00072
640081009324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081009325	active site
640081009326	phosphorylation site [posttranslational modification]
640081009327	intermolecular recognition site; other site
640081009328	dimerization interface [polypeptide binding]; other site
640081009329	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
640081009330	putative binding surface; other site
640081009331	active site
640081009332	intracellular septation protein A; Reviewed; Region: PRK00259
640081009333	YciI-like protein; Reviewed; Region: PRK11370
640081009334	BolA-like protein; Region: BolA; pfam01722
640081009335	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
640081009336	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081009337	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
640081009338	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081009339	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081009340	metal binding site [ion binding]; metal-binding site
640081009341	active site
640081009342	Hemerythrin; Region: Hemerythrin; cd12107
640081009343	Fe binding site [ion binding]; other site
640081009344	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
640081009345	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
640081009346	dimerization interface [polypeptide binding]; other site
640081009347	ATP binding site [chemical binding]; other site
640081009348	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
640081009349	dimerization interface [polypeptide binding]; other site
640081009350	ATP binding site [chemical binding]; other site
640081009351	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
640081009352	putative active site [active]
640081009353	catalytic triad [active]
640081009354	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081009355	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081009356	metal binding site [ion binding]; metal-binding site
640081009357	active site
640081009358	I-site; other site
640081009359	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
640081009360	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081009361	dimerization interface [polypeptide binding]; other site
640081009362	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081009363	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081009364	metal binding site [ion binding]; metal-binding site
640081009365	active site
640081009366	I-site; other site
640081009367	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081009368	ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301
640081009369	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
640081009370	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081009371	N-terminal plug; other site
640081009372	ligand-binding site [chemical binding]; other site
640081009373	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
640081009374	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
640081009375	putative active site [active]
640081009376	Zn binding site [ion binding]; other site
640081009377	Uncharacterized conserved protein [Function unknown]; Region: COG0062
640081009378	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
640081009379	putative ATP binding site [chemical binding]; other site
640081009380	putative substrate binding site [chemical binding]; other site
640081009381	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
640081009382	EamA-like transporter family; Region: EamA; pfam00892
640081009383	EamA-like transporter family; Region: EamA; pfam00892
640081009384	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
640081009385	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
640081009386	active site
640081009387	FMN binding site [chemical binding]; other site
640081009388	substrate binding site [chemical binding]; other site
640081009389	3Fe-4S cluster binding site [ion binding]; other site
640081009390	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
640081009391	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
640081009392	dimerization interface [polypeptide binding]; other site
640081009393	active site
640081009394	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081009395	S-adenosylmethionine binding site [chemical binding]; other site
640081009396	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
640081009397	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
640081009398	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081009399	catalytic residue [active]
640081009400	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
640081009401	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
640081009402	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
640081009403	homoserine dehydrogenase; Provisional; Region: PRK06349
640081009404	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
640081009405	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
640081009406	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
640081009407	aminotransferase AlaT; Validated; Region: PRK09265
640081009408	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081009409	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081009410	homodimer interface [polypeptide binding]; other site
640081009411	catalytic residue [active]
640081009412	aminotransferase; Validated; Region: PRK08175
640081009413	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081009414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081009415	homodimer interface [polypeptide binding]; other site
640081009416	catalytic residue [active]
640081009417	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
640081009418	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
640081009419	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
640081009420	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
640081009421	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
640081009422	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
640081009423	substrate binding site [chemical binding]; other site
640081009424	oxyanion hole (OAH) forming residues; other site
640081009425	trimer interface [polypeptide binding]; other site
640081009426	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
640081009427	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
640081009428	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
640081009429	metal binding site [ion binding]; metal-binding site
640081009430	substrate binding pocket [chemical binding]; other site
640081009431	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081009432	TPR motif; other site
640081009433	Tetratricopeptide repeat; Region: TPR_16; pfam13432
640081009434	binding surface
640081009435	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
640081009436	non-specific DNA binding site [nucleotide binding]; other site
640081009437	salt bridge; other site
640081009438	sequence-specific DNA binding site [nucleotide binding]; other site
640081009439	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
640081009440	acyl-activating enzyme (AAE) consensus motif; other site
640081009441	AMP binding site [chemical binding]; other site
640081009442	active site
640081009443	CoA binding site [chemical binding]; other site
640081009444	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
640081009445	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
640081009446	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
640081009447	dimer interface [polypeptide binding]; other site
640081009448	tetramer interface [polypeptide binding]; other site
640081009449	PYR/PP interface [polypeptide binding]; other site
640081009450	TPP binding site [chemical binding]; other site
640081009451	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
640081009452	TPP-binding site [chemical binding]; other site
640081009453	Esterase/lipase [General function prediction only]; Region: COG1647
640081009454	Uncharacterized conserved protein [Function unknown]; Region: COG1434
640081009455	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
640081009456	putative active site [active]
640081009457	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
640081009458	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
640081009459	acyl-activating enzyme (AAE) consensus motif; other site
640081009460	AMP binding site [chemical binding]; other site
640081009461	active site
640081009462	CoA binding site [chemical binding]; other site
640081009463	Response regulator receiver domain; Region: Response_reg; pfam00072
640081009464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081009465	active site
640081009466	phosphorylation site [posttranslational modification]
640081009467	intermolecular recognition site; other site
640081009468	dimerization interface [polypeptide binding]; other site
640081009469	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081009470	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081009471	metal binding site [ion binding]; metal-binding site
640081009472	active site
640081009473	I-site; other site
640081009474	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
640081009475	NlpC/P60 family; Region: NLPC_P60; pfam00877
640081009476	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
640081009477	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
640081009478	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
640081009479	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081009480	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
640081009481	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
640081009482	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
640081009483	ligand binding site [chemical binding]; other site
640081009484	homodimer interface [polypeptide binding]; other site
640081009485	NAD(P) binding site [chemical binding]; other site
640081009486	trimer interface B [polypeptide binding]; other site
640081009487	trimer interface A [polypeptide binding]; other site
640081009488	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
640081009489	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
640081009490	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
640081009491	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
640081009492	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
640081009493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081009494	ABC-ATPase subunit interface; other site
640081009495	putative PBP binding loops; other site
640081009496	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081009497	dimer interface [polypeptide binding]; other site
640081009498	conserved gate region; other site
640081009499	putative PBP binding loops; other site
640081009500	ABC-ATPase subunit interface; other site
640081009501	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
640081009502	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
640081009503	Walker A/P-loop; other site
640081009504	ATP binding site [chemical binding]; other site
640081009505	Q-loop/lid; other site
640081009506	ABC transporter signature motif; other site
640081009507	Walker B; other site
640081009508	D-loop; other site
640081009509	H-loop/switch region; other site
640081009510	TOBE domain; Region: TOBE_2; pfam08402
640081009511	HAMP domain; Region: HAMP; pfam00672
640081009512	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081009513	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081009514	metal binding site [ion binding]; metal-binding site
640081009515	active site
640081009516	I-site; other site
640081009517	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
640081009518	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
640081009519	ATP binding site [chemical binding]; other site
640081009520	Mg++ binding site [ion binding]; other site
640081009521	motif III; other site
640081009522	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
640081009523	nucleotide binding region [chemical binding]; other site
640081009524	ATP-binding site [chemical binding]; other site
640081009525	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
640081009526	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
640081009527	RNA polymerase sigma factor; Provisional; Region: PRK12528
640081009528	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081009529	Protein of unknown function (DUF1327); Region: DUF1327; pfam07041
640081009530	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081009531	DNA binding residues [nucleotide binding]
640081009532	fec operon regulator FecR; Reviewed; Region: PRK09774
640081009533	FecR protein; Region: FecR; pfam04773
640081009534	Secretin and TonB N terminus short domain; Region: STN; smart00965
640081009535	ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049
640081009536	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081009537	N-terminal plug; other site
640081009538	ligand-binding site [chemical binding]; other site
640081009539	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
640081009540	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
640081009541	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
640081009542	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
640081009543	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
640081009544	substrate binding pocket [chemical binding]; other site
640081009545	membrane-bound complex binding site; other site
640081009546	hinge residues; other site
640081009547	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081009548	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081009549	metal binding site [ion binding]; metal-binding site
640081009550	active site
640081009551	I-site; other site
640081009552	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
640081009553	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
640081009554	cobalt transport protein CbiM; Validated; Region: PRK08319
640081009555	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
640081009556	cobalt transport protein CbiN; Provisional; Region: PRK02898
640081009557	Cobalt transport protein; Region: CbiQ; cl00463
640081009558	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
640081009559	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
640081009560	Walker A/P-loop; other site
640081009561	ATP binding site [chemical binding]; other site
640081009562	Q-loop/lid; other site
640081009563	ABC transporter signature motif; other site
640081009564	Walker B; other site
640081009565	D-loop; other site
640081009566	H-loop/switch region; other site
640081009567	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
640081009568	active site
640081009569	SAM binding site [chemical binding]; other site
640081009570	homodimer interface [polypeptide binding]; other site
640081009571	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
640081009572	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
640081009573	putative active site [active]
640081009574	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
640081009575	putative active site [active]
640081009576	Precorrin-8X methylmutase; Region: CbiC; pfam02570
640081009577	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
640081009578	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
640081009579	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
640081009580	active site
640081009581	putative homodimer interface [polypeptide binding]; other site
640081009582	SAM binding site [chemical binding]; other site
640081009583	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
640081009584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081009585	S-adenosylmethionine binding site [chemical binding]; other site
640081009586	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
640081009587	active site
640081009588	SAM binding site [chemical binding]; other site
640081009589	homodimer interface [polypeptide binding]; other site
640081009590	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
640081009591	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
640081009592	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
640081009593	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
640081009594	active site
640081009595	SAM binding site [chemical binding]; other site
640081009596	homodimer interface [polypeptide binding]; other site
640081009597	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
640081009598	dimer interface [polypeptide binding]; other site
640081009599	[2Fe-2S] cluster binding site [ion binding]; other site
640081009600	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
640081009601	active site
640081009602	SAM binding site [chemical binding]; other site
640081009603	homodimer interface [polypeptide binding]; other site
640081009604	Flagellin N-methylase; Region: FliB; cl00497
640081009605	hypothetical protein; Provisional; Region: PRK10279
640081009606	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
640081009607	nucleophile elbow; other site
640081009608	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
640081009609	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
640081009610	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
640081009611	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
640081009612	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
640081009613	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
640081009614	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
640081009615	Secretin and TonB N terminus short domain; Region: STN; smart00965
640081009616	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
640081009617	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081009618	N-terminal plug; other site
640081009619	ligand-binding site [chemical binding]; other site
640081009620	fec operon regulator FecR; Reviewed; Region: PRK09774
640081009621	FecR protein; Region: FecR; pfam04773
640081009622	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
640081009623	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081009624	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081009625	DNA binding residues [nucleotide binding]
640081009626	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
640081009627	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
640081009628	quinone interaction residues [chemical binding]; other site
640081009629	active site
640081009630	catalytic residues [active]
640081009631	FMN binding site [chemical binding]; other site
640081009632	substrate binding site [chemical binding]; other site
640081009633	electron transport complex protein RsxA; Provisional; Region: PRK05151
640081009634	electron transport complex protein RnfB; Provisional; Region: PRK05113
640081009635	Putative Fe-S cluster; Region: FeS; pfam04060
640081009636	4Fe-4S binding domain; Region: Fer4; pfam00037
640081009637	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
640081009638	SLBB domain; Region: SLBB; pfam10531
640081009639	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
640081009640	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
640081009641	FMN-binding domain; Region: FMN_bind; cl01081
640081009642	electron transport complex RsxE subunit; Provisional; Region: PRK12405
640081009643	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
640081009644	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
640081009645	minor groove reading motif; other site
640081009646	helix-hairpin-helix signature motif; other site
640081009647	substrate binding pocket [chemical binding]; other site
640081009648	active site
640081009649	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
640081009650	FIST C domain; Region: FIST_C; pfam10442
640081009651	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
640081009652	PAS domain; Region: PAS_9; pfam13426
640081009653	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081009654	putative active site [active]
640081009655	heme pocket [chemical binding]; other site
640081009656	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
640081009657	Tar ligand binding domain homologue; Region: TarH; pfam02203
640081009658	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081009659	dimerization interface [polypeptide binding]; other site
640081009660	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081009661	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081009662	dimer interface [polypeptide binding]; other site
640081009663	putative CheW interface [polypeptide binding]; other site
640081009664	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
640081009665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081009666	Walker A motif; other site
640081009667	ATP binding site [chemical binding]; other site
640081009668	Walker B motif; other site
640081009669	arginine finger; other site
640081009670	NMT1/THI5 like; Region: NMT1; pfam09084
640081009671	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
640081009672	substrate binding pocket [chemical binding]; other site
640081009673	membrane-bound complex binding site; other site
640081009674	PAS domain S-box; Region: sensory_box; TIGR00229
640081009675	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081009676	putative active site [active]
640081009677	heme pocket [chemical binding]; other site
640081009678	PAS domain S-box; Region: sensory_box; TIGR00229
640081009679	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081009680	putative active site [active]
640081009681	heme pocket [chemical binding]; other site
640081009682	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081009683	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081009684	metal binding site [ion binding]; metal-binding site
640081009685	active site
640081009686	I-site; other site
640081009687	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
640081009688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
640081009689	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
640081009690	catalytic core [active]
640081009691	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
640081009692	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
640081009693	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
640081009694	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
640081009695	Walker A motif; other site
640081009696	ATP binding site [chemical binding]; other site
640081009697	Walker B motif; other site
640081009698	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
640081009699	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081009700	dimerization interface [polypeptide binding]; other site
640081009701	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081009702	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081009703	dimer interface [polypeptide binding]; other site
640081009704	phosphorylation site [posttranslational modification]
640081009705	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081009706	ATP binding site [chemical binding]; other site
640081009707	Mg2+ binding site [ion binding]; other site
640081009708	G-X-G motif; other site
640081009709	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
640081009710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081009711	active site
640081009712	phosphorylation site [posttranslational modification]
640081009713	intermolecular recognition site; other site
640081009714	dimerization interface [polypeptide binding]; other site
640081009715	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081009716	Zn2+ binding site [ion binding]; other site
640081009717	Mg2+ binding site [ion binding]; other site
640081009718	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
640081009719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081009720	active site
640081009721	phosphorylation site [posttranslational modification]
640081009722	intermolecular recognition site; other site
640081009723	dimerization interface [polypeptide binding]; other site
640081009724	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081009725	Zn2+ binding site [ion binding]; other site
640081009726	Mg2+ binding site [ion binding]; other site
640081009727	PAS domain; Region: PAS_9; pfam13426
640081009728	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081009729	putative active site [active]
640081009730	heme pocket [chemical binding]; other site
640081009731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081009732	ATP binding site [chemical binding]; other site
640081009733	Mg2+ binding site [ion binding]; other site
640081009734	G-X-G motif; other site
640081009735	heat shock protein 90; Provisional; Region: PRK05218
640081009736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081009737	ATP binding site [chemical binding]; other site
640081009738	Mg2+ binding site [ion binding]; other site
640081009739	G-X-G motif; other site
640081009740	FOG: CBS domain [General function prediction only]; Region: COG0517
640081009741	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
640081009742	FOG: CBS domain [General function prediction only]; Region: COG0517
640081009743	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
640081009744	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081009745	PAS domain; Region: PAS_9; pfam13426
640081009746	putative active site [active]
640081009747	heme pocket [chemical binding]; other site
640081009748	PAS fold; Region: PAS_4; pfam08448
640081009749	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081009750	putative active site [active]
640081009751	heme pocket [chemical binding]; other site
640081009752	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
640081009753	GAF domain; Region: GAF; pfam01590
640081009754	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081009755	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081009756	metal binding site [ion binding]; metal-binding site
640081009757	active site
640081009758	I-site; other site
640081009759	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
640081009760	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
640081009761	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
640081009762	Protein of unknown function (DUF3457); Region: DUF3457; pfam11939
640081009763	HupF/HypC family; Region: HupF_HypC; pfam01455
640081009764	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
640081009765	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
640081009766	putative substrate-binding site; other site
640081009767	nickel binding site [ion binding]; other site
640081009768	hydrogenase 2 large subunit; Provisional; Region: PRK10467
640081009769	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
640081009770	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
640081009771	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
640081009772	4Fe-4S binding domain; Region: Fer4_6; pfam12837
640081009773	hydrogenase 2 small subunit; Provisional; Region: PRK10468
640081009774	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
640081009775	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
640081009776	ligand binding site [chemical binding]; other site
640081009777	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
640081009778	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
640081009779	homodimer interface [polypeptide binding]; other site
640081009780	substrate-cofactor binding pocket; other site
640081009781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081009782	catalytic residue [active]
640081009783	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
640081009784	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
640081009785	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
640081009786	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
640081009787	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
640081009788	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
640081009789	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
640081009790	nickel binding site [ion binding]; other site
640081009791	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
640081009792	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
640081009793	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
640081009794	catalytic loop [active]
640081009795	iron binding site [ion binding]; other site
640081009796	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
640081009797	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
640081009798	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
640081009799	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
640081009800	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
640081009801	SLBB domain; Region: SLBB; pfam10531
640081009802	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
640081009803	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
640081009804	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
640081009805	NAD binding site [chemical binding]; other site
640081009806	homotetramer interface [polypeptide binding]; other site
640081009807	homodimer interface [polypeptide binding]; other site
640081009808	substrate binding site [chemical binding]; other site
640081009809	active site
640081009810	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
640081009811	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
640081009812	dimer interaction site [polypeptide binding]; other site
640081009813	substrate-binding tunnel; other site
640081009814	active site
640081009815	catalytic site [active]
640081009816	substrate binding site [chemical binding]; other site
640081009817	phosphate acetyltransferase; Provisional; Region: PRK11890
640081009818	Acetokinase family; Region: Acetate_kinase; cl17229
640081009819	propionate/acetate kinase; Provisional; Region: PRK12379
640081009820	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
640081009821	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
640081009822	active site
640081009823	dimer interface [polypeptide binding]; other site
640081009824	effector binding site; other site
640081009825	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081009826	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081009827	metal binding site [ion binding]; metal-binding site
640081009828	active site
640081009829	I-site; other site
640081009830	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
640081009831	dimer interface [polypeptide binding]; other site
640081009832	ADP-ribose binding site [chemical binding]; other site
640081009833	active site
640081009834	nudix motif; other site
640081009835	metal binding site [ion binding]; metal-binding site
640081009836	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
640081009837	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
640081009838	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
640081009839	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
640081009840	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
640081009841	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
640081009842	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
640081009843	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
640081009844	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
640081009845	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
640081009846	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
640081009847	4Fe-4S binding domain; Region: Fer4; pfam00037
640081009848	4Fe-4S binding domain; Region: Fer4; pfam00037
640081009849	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
640081009850	NADH dehydrogenase subunit G; Validated; Region: PRK09129
640081009851	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
640081009852	catalytic loop [active]
640081009853	iron binding site [ion binding]; other site
640081009854	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
640081009855	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
640081009856	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
640081009857	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
640081009858	SLBB domain; Region: SLBB; pfam10531
640081009859	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
640081009860	NADH dehydrogenase subunit E; Validated; Region: PRK07539
640081009861	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
640081009862	putative dimer interface [polypeptide binding]; other site
640081009863	[2Fe-2S] cluster binding site [ion binding]; other site
640081009864	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
640081009865	NADH dehydrogenase subunit D; Validated; Region: PRK06075
640081009866	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
640081009867	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
640081009868	NADH dehydrogenase subunit B; Validated; Region: PRK06411
640081009869	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
640081009870	triosephosphate isomerase; Provisional; Region: PRK14565
640081009871	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
640081009872	dimer interface [polypeptide binding]; other site
640081009873	substrate binding site [chemical binding]; other site
640081009874	catalytic triad [active]
640081009875	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14252
640081009876	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
640081009877	Walker A/P-loop; other site
640081009878	ATP binding site [chemical binding]; other site
640081009879	Q-loop/lid; other site
640081009880	ABC transporter signature motif; other site
640081009881	Walker B; other site
640081009882	D-loop; other site
640081009883	H-loop/switch region; other site
640081009884	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
640081009885	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081009886	dimer interface [polypeptide binding]; other site
640081009887	conserved gate region; other site
640081009888	putative PBP binding loops; other site
640081009889	ABC-ATPase subunit interface; other site
640081009890	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
640081009891	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081009892	dimer interface [polypeptide binding]; other site
640081009893	conserved gate region; other site
640081009894	putative PBP binding loops; other site
640081009895	ABC-ATPase subunit interface; other site
640081009896	phosphate binding protein; Region: ptsS_2; TIGR02136
640081009897	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
640081009898	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
640081009899	active site
640081009900	substrate binding site [chemical binding]; other site
640081009901	metal binding site [ion binding]; metal-binding site
640081009902	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
640081009903	dihydropteroate synthase; Region: DHPS; TIGR01496
640081009904	substrate binding pocket [chemical binding]; other site
640081009905	dimer interface [polypeptide binding]; other site
640081009906	inhibitor binding site; inhibition site
640081009907	FtsH Extracellular; Region: FtsH_ext; pfam06480
640081009908	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
640081009909	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081009910	Walker A motif; other site
640081009911	ATP binding site [chemical binding]; other site
640081009912	Walker B motif; other site
640081009913	arginine finger; other site
640081009914	Peptidase family M41; Region: Peptidase_M41; pfam01434
640081009915	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
640081009916	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081009917	S-adenosylmethionine binding site [chemical binding]; other site
640081009918	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
640081009919	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
640081009920	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
640081009921	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
640081009922	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
640081009923	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
640081009924	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
640081009925	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
640081009926	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
640081009927	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
640081009928	ATP-grasp domain; Region: ATP-grasp_4; cl17255
640081009929	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
640081009930	IMP binding site; other site
640081009931	dimer interface [polypeptide binding]; other site
640081009932	interdomain contacts; other site
640081009933	partial ornithine binding site; other site
640081009934	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
640081009935	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
640081009936	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
640081009937	catalytic site [active]
640081009938	subunit interface [polypeptide binding]; other site
640081009939	dihydrodipicolinate reductase; Provisional; Region: PRK00048
640081009940	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
640081009941	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
640081009942	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
640081009943	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
640081009944	ferric uptake regulator; Provisional; Region: fur; PRK09462
640081009945	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
640081009946	metal binding site 2 [ion binding]; metal-binding site
640081009947	putative DNA binding helix; other site
640081009948	metal binding site 1 [ion binding]; metal-binding site
640081009949	dimer interface [polypeptide binding]; other site
640081009950	structural Zn2+ binding site [ion binding]; other site
640081009951	Predicted membrane protein [Function unknown]; Region: COG2119
640081009952	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
640081009953	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
640081009954	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
640081009955	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
640081009956	substrate binding pocket [chemical binding]; other site
640081009957	membrane-bound complex binding site; other site
640081009958	SprA-related family; Region: SprA-related; pfam12118
640081009959	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
640081009960	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
640081009961	Walker A/P-loop; other site
640081009962	ATP binding site [chemical binding]; other site
640081009963	Q-loop/lid; other site
640081009964	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
640081009965	ABC transporter signature motif; other site
640081009966	Walker B; other site
640081009967	D-loop; other site
640081009968	H-loop/switch region; other site
640081009969	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
640081009970	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
640081009971	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
640081009972	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
640081009973	ferrochelatase; Reviewed; Region: hemH; PRK00035
640081009974	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
640081009975	C-terminal domain interface [polypeptide binding]; other site
640081009976	active site
640081009977	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
640081009978	active site
640081009979	N-terminal domain interface [polypeptide binding]; other site
640081009980	thioredoxin 2; Provisional; Region: PRK10996
640081009981	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
640081009982	catalytic residues [active]
640081009983	Family description; Region: VCBS; pfam13517
640081009984	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081009985	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081009986	dimerization interface [polypeptide binding]; other site
640081009987	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081009988	dimer interface [polypeptide binding]; other site
640081009989	putative CheW interface [polypeptide binding]; other site
640081009990	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
640081009991	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
640081009992	active site
640081009993	ATP binding site [chemical binding]; other site
640081009994	substrate binding site [chemical binding]; other site
640081009995	activation loop (A-loop); other site
640081009996	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081009997	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081009998	ligand binding site [chemical binding]; other site
640081009999	flexible hinge region; other site
640081010000	GrpE; Region: GrpE; pfam01025
640081010001	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
640081010002	dimer interface [polypeptide binding]; other site
640081010003	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
640081010004	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
640081010005	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
640081010006	nucleotide binding site [chemical binding]; other site
640081010007	chaperone protein DnaJ; Provisional; Region: PRK10767
640081010008	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
640081010009	HSP70 interaction site [polypeptide binding]; other site
640081010010	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
640081010011	substrate binding site [polypeptide binding]; other site
640081010012	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
640081010013	Zn binding sites [ion binding]; other site
640081010014	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
640081010015	dimer interface [polypeptide binding]; other site
640081010016	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
640081010017	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
640081010018	putative ligand binding site [chemical binding]; other site
640081010019	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
640081010020	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
640081010021	active site
640081010022	HIGH motif; other site
640081010023	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
640081010024	KMSKS motif; other site
640081010025	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
640081010026	tRNA binding surface [nucleotide binding]; other site
640081010027	anticodon binding site; other site
640081010028	TPR repeat; Region: TPR_11; pfam13414
640081010029	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081010030	binding surface
640081010031	TPR motif; other site
640081010032	Tetratricopeptide repeat; Region: TPR_16; pfam13432
640081010033	SnoaL-like domain; Region: SnoaL_3; pfam13474
640081010034	SnoaL-like domain; Region: SnoaL_2; pfam12680
640081010035	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
640081010036	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
640081010037	substrate binding site [chemical binding]; other site
640081010038	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
640081010039	substrate binding site [chemical binding]; other site
640081010040	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
640081010041	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
640081010042	putative active site [active]
640081010043	putative metal binding site [ion binding]; other site
640081010044	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
640081010045	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
640081010046	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
640081010047	ATP binding site [chemical binding]; other site
640081010048	putative Mg++ binding site [ion binding]; other site
640081010049	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
640081010050	nucleotide binding region [chemical binding]; other site
640081010051	ATP-binding site [chemical binding]; other site
640081010052	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
640081010053	HRDC domain; Region: HRDC; pfam00570
640081010054	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
640081010055	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081010056	Zn2+ binding site [ion binding]; other site
640081010057	Mg2+ binding site [ion binding]; other site
640081010058	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
640081010059	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
640081010060	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
640081010061	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
640081010062	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
640081010063	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
640081010064	DNA binding site [nucleotide binding]
640081010065	active site
640081010066	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
640081010067	AlkA N-terminal domain; Region: AlkA_N; cl05528
640081010068	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
640081010069	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
640081010070	minor groove reading motif; other site
640081010071	helix-hairpin-helix signature motif; other site
640081010072	substrate binding pocket [chemical binding]; other site
640081010073	active site
640081010074	Predicted permeases [General function prediction only]; Region: COG0679
640081010075	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
640081010076	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081010077	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
640081010078	dimerization interface [polypeptide binding]; other site
640081010079	substrate binding pocket [chemical binding]; other site
640081010080	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
640081010081	GTP binding site; other site
640081010082	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
640081010083	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
640081010084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081010085	PAS domain; Region: PAS_9; pfam13426
640081010086	putative active site [active]
640081010087	heme pocket [chemical binding]; other site
640081010088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081010089	PAS domain; Region: PAS_9; pfam13426
640081010090	putative active site [active]
640081010091	heme pocket [chemical binding]; other site
640081010092	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081010093	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081010094	metal binding site [ion binding]; metal-binding site
640081010095	active site
640081010096	I-site; other site
640081010097	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081010098	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
640081010099	Domain of unknown function DUF21; Region: DUF21; pfam01595
640081010100	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
640081010101	Transporter associated domain; Region: CorC_HlyC; smart01091
640081010102	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
640081010103	GIY-YIG motif/motif A; other site
640081010104	putative active site [active]
640081010105	putative metal binding site [ion binding]; other site
640081010106	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
640081010107	FOG: CBS domain [General function prediction only]; Region: COG0517
640081010108	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
640081010109	FOG: CBS domain [General function prediction only]; Region: COG0517
640081010110	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
640081010111	PAS fold; Region: PAS_4; pfam08448
640081010112	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081010113	putative active site [active]
640081010114	heme pocket [chemical binding]; other site
640081010115	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081010116	PAS domain; Region: PAS_9; pfam13426
640081010117	putative active site [active]
640081010118	heme pocket [chemical binding]; other site
640081010119	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081010120	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081010121	metal binding site [ion binding]; metal-binding site
640081010122	active site
640081010123	I-site; other site
640081010124	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081010125	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
640081010126	Cytochrome c; Region: Cytochrom_C; pfam00034
640081010127	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
640081010128	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
640081010129	D-pathway; other site
640081010130	Low-spin heme binding site [chemical binding]; other site
640081010131	Putative water exit pathway; other site
640081010132	Binuclear center (active site) [active]
640081010133	K-pathway; other site
640081010134	Putative proton exit pathway; other site
640081010135	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
640081010136	PAS domain S-box; Region: sensory_box; TIGR00229
640081010137	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081010138	metal binding site [ion binding]; metal-binding site
640081010139	active site
640081010140	I-site; other site
640081010141	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081010142	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
640081010143	Subunit I/III interface [polypeptide binding]; other site
640081010144	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626
640081010145	MoxR-like ATPases [General function prediction only]; Region: COG0714
640081010146	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081010147	Walker A motif; other site
640081010148	ATP binding site [chemical binding]; other site
640081010149	Walker B motif; other site
640081010150	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
640081010151	4Fe-4S binding domain; Region: Fer4_5; pfam12801
640081010152	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
640081010153	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
640081010154	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
640081010155	metal ion-dependent adhesion site (MIDAS); other site
640081010156	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081010157	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081010158	ligand binding site [chemical binding]; other site
640081010159	flexible hinge region; other site
640081010160	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
640081010161	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
640081010162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081010163	PAS domain; Region: PAS_9; pfam13426
640081010164	putative active site [active]
640081010165	heme pocket [chemical binding]; other site
640081010166	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081010167	dimer interface [polypeptide binding]; other site
640081010168	putative CheW interface [polypeptide binding]; other site
640081010169	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
640081010170	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081010171	active site
640081010172	phosphorylation site [posttranslational modification]
640081010173	intermolecular recognition site; other site
640081010174	dimerization interface [polypeptide binding]; other site
640081010175	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
640081010176	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
640081010177	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
640081010178	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
640081010179	heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051
640081010180	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081010181	FeS/SAM binding site; other site
640081010182	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
640081010183	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
640081010184	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
640081010185	probable active site [active]
640081010186	ribonuclease R; Region: RNase_R; TIGR02063
640081010187	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
640081010188	RNB domain; Region: RNB; pfam00773
640081010189	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
640081010190	RNA binding site [nucleotide binding]; other site
640081010191	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
640081010192	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
640081010193	GDP-binding site [chemical binding]; other site
640081010194	ACT binding site; other site
640081010195	IMP binding site; other site
640081010196	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
640081010197	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
640081010198	dimer interface [polypeptide binding]; other site
640081010199	motif 1; other site
640081010200	active site
640081010201	motif 2; other site
640081010202	motif 3; other site
640081010203	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
640081010204	FtsH protease regulator HflC; Provisional; Region: PRK11029
640081010205	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
640081010206	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
640081010207	HflK protein; Region: hflK; TIGR01933
640081010208	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
640081010209	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
640081010210	HflX GTPase family; Region: HflX; cd01878
640081010211	G1 box; other site
640081010212	GTP/Mg2+ binding site [chemical binding]; other site
640081010213	Switch I region; other site
640081010214	G2 box; other site
640081010215	G3 box; other site
640081010216	Switch II region; other site
640081010217	G4 box; other site
640081010218	G5 box; other site
640081010219	bacterial Hfq-like; Region: Hfq; cd01716
640081010220	hexamer interface [polypeptide binding]; other site
640081010221	Sm1 motif; other site
640081010222	RNA binding site [nucleotide binding]; other site
640081010223	Sm2 motif; other site
640081010224	GTP-binding protein Der; Reviewed; Region: PRK00093
640081010225	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
640081010226	G1 box; other site
640081010227	GTP/Mg2+ binding site [chemical binding]; other site
640081010228	Switch I region; other site
640081010229	G2 box; other site
640081010230	Switch II region; other site
640081010231	G3 box; other site
640081010232	G4 box; other site
640081010233	G5 box; other site
640081010234	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
640081010235	G1 box; other site
640081010236	GTP/Mg2+ binding site [chemical binding]; other site
640081010237	Switch I region; other site
640081010238	G2 box; other site
640081010239	G3 box; other site
640081010240	Switch II region; other site
640081010241	G4 box; other site
640081010242	G5 box; other site
640081010243	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
640081010244	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
640081010245	Trp docking motif [polypeptide binding]; other site
640081010246	active site
640081010247	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
640081010248	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
640081010249	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
640081010250	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
640081010251	dimer interface [polypeptide binding]; other site
640081010252	motif 1; other site
640081010253	active site
640081010254	motif 2; other site
640081010255	motif 3; other site
640081010256	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
640081010257	anticodon binding site; other site
640081010258	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
640081010259	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
640081010260	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
640081010261	Helix-turn-helix domain; Region: HTH_25; pfam13413
640081010262	non-specific DNA binding site [nucleotide binding]; other site
640081010263	salt bridge; other site
640081010264	sequence-specific DNA binding site [nucleotide binding]; other site
640081010265	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
640081010266	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
640081010267	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081010268	binding surface
640081010269	TPR motif; other site
640081010270	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081010271	binding surface
640081010272	TPR motif; other site
640081010273	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
640081010274	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081010275	FeS/SAM binding site; other site
640081010276	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
640081010277	active site
640081010278	multimer interface [polypeptide binding]; other site
640081010279	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
640081010280	oxidoreductase; Provisional; Region: PRK10015
640081010281	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
640081010282	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
640081010283	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
640081010284	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
640081010285	Ligand binding site [chemical binding]; other site
640081010286	Electron transfer flavoprotein domain; Region: ETF; pfam01012
640081010287	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
640081010288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081010289	active site
640081010290	phosphorylation site [posttranslational modification]
640081010291	intermolecular recognition site; other site
640081010292	dimerization interface [polypeptide binding]; other site
640081010293	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081010294	DNA binding site [nucleotide binding]
640081010295	GAF domain; Region: GAF_3; pfam13492
640081010296	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081010297	dimer interface [polypeptide binding]; other site
640081010298	phosphorylation site [posttranslational modification]
640081010299	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081010300	ATP binding site [chemical binding]; other site
640081010301	Mg2+ binding site [ion binding]; other site
640081010302	G-X-G motif; other site
640081010303	DctM-like transporters; Region: DctM; pfam06808
640081010304	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
640081010305	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
640081010306	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
640081010307	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
640081010308	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
640081010309	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
640081010310	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
640081010311	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
640081010312	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081010313	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
640081010314	putative active site [active]
640081010315	heme pocket [chemical binding]; other site
640081010316	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081010317	dimer interface [polypeptide binding]; other site
640081010318	phosphorylation site [posttranslational modification]
640081010319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081010320	ATP binding site [chemical binding]; other site
640081010321	Mg2+ binding site [ion binding]; other site
640081010322	G-X-G motif; other site
640081010323	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
640081010324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081010325	active site
640081010326	phosphorylation site [posttranslational modification]
640081010327	intermolecular recognition site; other site
640081010328	dimerization interface [polypeptide binding]; other site
640081010329	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
640081010330	DNA binding residues [nucleotide binding]
640081010331	dimerization interface [polypeptide binding]; other site
640081010332	PAS fold; Region: PAS_4; pfam08448
640081010333	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081010334	putative active site [active]
640081010335	heme pocket [chemical binding]; other site
640081010336	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081010337	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081010338	metal binding site [ion binding]; metal-binding site
640081010339	active site
640081010340	I-site; other site
640081010341	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081010342	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
640081010343	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
640081010344	N-terminal plug; other site
640081010345	ligand-binding site [chemical binding]; other site
640081010346	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
640081010347	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081010348	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081010349	metal binding site [ion binding]; metal-binding site
640081010350	active site
640081010351	I-site; other site
640081010352	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
640081010353	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
640081010354	Ligand Binding Site [chemical binding]; other site
640081010355	TilS substrate binding domain; Region: TilS; pfam09179
640081010356	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
640081010357	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
640081010358	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
640081010359	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081010360	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081010361	metal binding site [ion binding]; metal-binding site
640081010362	active site
640081010363	I-site; other site
640081010364	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081010365	FIST N domain; Region: FIST; pfam08495
640081010366	FIST C domain; Region: FIST_C; pfam10442
640081010367	Protein of unknown function, DUF; Region: DUF411; pfam04214
640081010368	Flagellar protein YcgR; Region: YcgR_2; pfam12945
640081010369	PilZ domain; Region: PilZ; pfam07238
640081010370	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
640081010371	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
640081010372	catalytic residues [active]
640081010373	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
640081010374	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081010375	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081010376	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
640081010377	putative effector binding pocket; other site
640081010378	dimerization interface [polypeptide binding]; other site
640081010379	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
640081010380	DEAD-like helicases superfamily; Region: DEXDc; smart00487
640081010381	ATP binding site [chemical binding]; other site
640081010382	Mg++ binding site [ion binding]; other site
640081010383	motif III; other site
640081010384	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
640081010385	nucleotide binding region [chemical binding]; other site
640081010386	ATP-binding site [chemical binding]; other site
640081010387	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
640081010388	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
640081010389	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
640081010390	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081010391	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
640081010392	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
640081010393	Walker A/P-loop; other site
640081010394	ATP binding site [chemical binding]; other site
640081010395	Q-loop/lid; other site
640081010396	ABC transporter signature motif; other site
640081010397	Walker B; other site
640081010398	D-loop; other site
640081010399	H-loop/switch region; other site
640081010400	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
640081010401	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
640081010402	FtsX-like permease family; Region: FtsX; pfam02687
640081010403	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081010404	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081010405	dimerization interface [polypeptide binding]; other site
640081010406	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081010407	dimer interface [polypeptide binding]; other site
640081010408	phosphorylation site [posttranslational modification]
640081010409	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081010410	ATP binding site [chemical binding]; other site
640081010411	Mg2+ binding site [ion binding]; other site
640081010412	G-X-G motif; other site
640081010413	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
640081010414	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081010415	active site
640081010416	phosphorylation site [posttranslational modification]
640081010417	intermolecular recognition site; other site
640081010418	dimerization interface [polypeptide binding]; other site
640081010419	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081010420	DNA binding site [nucleotide binding]
640081010421	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
640081010422	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
640081010423	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081010424	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
640081010425	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
640081010426	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
640081010427	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
640081010428	homodimer interface [polypeptide binding]; other site
640081010429	substrate-cofactor binding pocket; other site
640081010430	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081010431	catalytic residue [active]
640081010432	amidophosphoribosyltransferase; Provisional; Region: PRK09246
640081010433	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
640081010434	active site
640081010435	tetramer interface [polypeptide binding]; other site
640081010436	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
640081010437	active site
640081010438	Colicin V production protein; Region: Colicin_V; pfam02674
640081010439	Sporulation related domain; Region: SPOR; pfam05036
640081010440	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
640081010441	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
640081010442	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
640081010443	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
640081010444	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
640081010445	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
640081010446	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
640081010447	substrate binding site [chemical binding]; other site
640081010448	active site
640081010449	catalytic residues [active]
640081010450	heterodimer interface [polypeptide binding]; other site
640081010451	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
640081010452	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
640081010453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081010454	catalytic residue [active]
640081010455	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
640081010456	active site
640081010457	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
640081010458	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
640081010459	dimerization interface 3.5A [polypeptide binding]; other site
640081010460	active site
640081010461	FimV N-terminal domain; Region: FimV_core; TIGR03505
640081010462	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
640081010463	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
640081010464	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
640081010465	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
640081010466	tartrate dehydrogenase; Region: TTC; TIGR02089
640081010467	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
640081010468	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
640081010469	substrate binding site [chemical binding]; other site
640081010470	Predicted small secreted protein [Function unknown]; Region: COG5510
640081010471	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
640081010472	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
640081010473	substrate binding site [chemical binding]; other site
640081010474	ligand binding site [chemical binding]; other site
640081010475	Peptidase family M48; Region: Peptidase_M48; pfam01435
640081010476	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
640081010477	Major Facilitator Superfamily; Region: MFS_1; pfam07690
640081010478	putative substrate translocation pore; other site
640081010479	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
640081010480	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
640081010481	Tetramer interface [polypeptide binding]; other site
640081010482	active site
640081010483	FMN-binding site [chemical binding]; other site
640081010484	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
640081010485	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
640081010486	active site
640081010487	Protein of unknown function, DUF; Region: DUF411; cl01142
640081010488	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
640081010489	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
640081010490	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
640081010491	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
640081010492	dimer interface [polypeptide binding]; other site
640081010493	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081010494	catalytic residue [active]
640081010495	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
640081010496	glutamate dehydrogenase; Provisional; Region: PRK09414
640081010497	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
640081010498	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
640081010499	NAD(P) binding site [chemical binding]; other site
640081010500	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
640081010501	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
640081010502	acyl-activating enzyme (AAE) consensus motif; other site
640081010503	putative AMP binding site [chemical binding]; other site
640081010504	putative active site [active]
640081010505	putative CoA binding site [chemical binding]; other site
640081010506	FOG: CBS domain [General function prediction only]; Region: COG0517
640081010507	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
640081010508	Part of AAA domain; Region: AAA_19; pfam13245
640081010509	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
640081010510	Family description; Region: UvrD_C_2; pfam13538
640081010511	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
640081010512	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
640081010513	Ferredoxin [Energy production and conversion]; Region: COG1146
640081010514	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
640081010515	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
640081010516	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
640081010517	catalytic residues [active]
640081010518	transcription termination factor Rho; Provisional; Region: rho; PRK09376
640081010519	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
640081010520	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
640081010521	RNA binding site [nucleotide binding]; other site
640081010522	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
640081010523	multimer interface [polypeptide binding]; other site
640081010524	Walker A motif; other site
640081010525	ATP binding site [chemical binding]; other site
640081010526	Walker B motif; other site
640081010527	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
640081010528	Cytochrome c553 [Energy production and conversion]; Region: COG2863
640081010529	Cytochrome c; Region: Cytochrom_C; cl11414
640081010530	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
640081010531	catalytic site [active]
640081010532	putative active site [active]
640081010533	putative substrate binding site [chemical binding]; other site
640081010534	dimer interface [polypeptide binding]; other site
640081010535	Peptidase family M48; Region: Peptidase_M48; pfam01435
640081010536	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
640081010537	aromatic arch; other site
640081010538	DCoH dimer interaction site [polypeptide binding]; other site
640081010539	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
640081010540	DCoH tetramer interaction site [polypeptide binding]; other site
640081010541	substrate binding site [chemical binding]; other site
640081010542	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
640081010543	GTPase RsgA; Reviewed; Region: PRK00098
640081010544	RNA binding site [nucleotide binding]; other site
640081010545	homodimer interface [polypeptide binding]; other site
640081010546	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
640081010547	GTPase/Zn-binding domain interface [polypeptide binding]; other site
640081010548	GTP/Mg2+ binding site [chemical binding]; other site
640081010549	G4 box; other site
640081010550	G5 box; other site
640081010551	G1 box; other site
640081010552	Switch I region; other site
640081010553	G2 box; other site
640081010554	G3 box; other site
640081010555	Switch II region; other site
640081010556	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
640081010557	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081010558	S-adenosylmethionine binding site [chemical binding]; other site
640081010559	2-isopropylmalate synthase; Validated; Region: PRK03739
640081010560	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
640081010561	active site
640081010562	catalytic residues [active]
640081010563	metal binding site [ion binding]; metal-binding site
640081010564	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
640081010565	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
640081010566	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
640081010567	putative DNA binding site [nucleotide binding]; other site
640081010568	putative Zn2+ binding site [ion binding]; other site
640081010569	AsnC family; Region: AsnC_trans_reg; pfam01037
640081010570	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
640081010571	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
640081010572	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
640081010573	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
640081010574	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
640081010575	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
640081010576	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
640081010577	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
640081010578	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
640081010579	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
640081010580	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
640081010581	ProQ/FINO family; Region: ProQ; smart00945
640081010582	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
640081010583	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
640081010584	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
640081010585	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
640081010586	Uncharacterized conserved protein [Function unknown]; Region: COG2308
640081010587	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
640081010588	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081010589	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081010590	dimer interface [polypeptide binding]; other site
640081010591	putative CheW interface [polypeptide binding]; other site
640081010592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081010593	PAS domain; Region: PAS_9; pfam13426
640081010594	putative active site [active]
640081010595	heme pocket [chemical binding]; other site
640081010596	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081010597	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081010598	dimer interface [polypeptide binding]; other site
640081010599	putative CheW interface [polypeptide binding]; other site
640081010600	beta-ketothiolase; Provisional; Region: PRK09051
640081010601	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
640081010602	dimer interface [polypeptide binding]; other site
640081010603	active site
640081010604	CobD/CbiB family protein; Provisional; Region: PRK07630
640081010605	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
640081010606	putative active site [active]
640081010607	putative CoA binding site [chemical binding]; other site
640081010608	nudix motif; other site
640081010609	metal binding site [ion binding]; metal-binding site
640081010610	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
640081010611	catalytic motif [active]
640081010612	Catalytic residue [active]
640081010613	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
640081010614	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
640081010615	catalytic triad [active]
640081010616	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
640081010617	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
640081010618	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
640081010619	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
640081010620	argininosuccinate synthase; Provisional; Region: PRK13820
640081010621	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
640081010622	ANP binding site [chemical binding]; other site
640081010623	Substrate Binding Site II [chemical binding]; other site
640081010624	Substrate Binding Site I [chemical binding]; other site
640081010625	ornithine carbamoyltransferase; Provisional; Region: PRK00779
640081010626	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
640081010627	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
640081010628	acetylornithine aminotransferase; Provisional; Region: PRK02627
640081010629	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
640081010630	inhibitor-cofactor binding pocket; inhibition site
640081010631	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081010632	catalytic residue [active]
640081010633	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
640081010634	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
640081010635	P-loop; other site
640081010636	Magnesium ion binding site [ion binding]; other site
640081010637	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
640081010638	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
640081010639	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
640081010640	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
640081010641	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
640081010642	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
640081010643	substrate binding site [chemical binding]; other site
640081010644	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
640081010645	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081010646	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081010647	homodimer interface [polypeptide binding]; other site
640081010648	catalytic residue [active]
640081010649	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
640081010650	short chain dehydrogenase; Provisional; Region: PRK06123
640081010651	classical (c) SDRs; Region: SDR_c; cd05233
640081010652	NAD(P) binding site [chemical binding]; other site
640081010653	active site
640081010654	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
640081010655	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
640081010656	6-phosphofructokinase; Provisional; Region: PRK14072
640081010657	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
640081010658	active site
640081010659	ADP/pyrophosphate binding site [chemical binding]; other site
640081010660	dimerization interface [polypeptide binding]; other site
640081010661	allosteric effector site; other site
640081010662	fructose-1,6-bisphosphate binding site; other site
640081010663	adenylate kinase; Reviewed; Region: adk; PRK00279
640081010664	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
640081010665	AMP-binding site [chemical binding]; other site
640081010666	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
640081010667	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
640081010668	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
640081010669	Ligand binding site; other site
640081010670	oligomer interface; other site
640081010671	Uncharacterized conserved protein [Function unknown]; Region: COG2835
640081010672	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
640081010673	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
640081010674	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
640081010675	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
640081010676	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
640081010677	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
640081010678	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
640081010679	generic binding surface II; other site
640081010680	generic binding surface I; other site
640081010681	superoxide dismutase; Provisional; Region: PRK10543
640081010682	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
640081010683	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
640081010684	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
640081010685	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
640081010686	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081010687	Walker A motif; other site
640081010688	ATP binding site [chemical binding]; other site
640081010689	Walker B motif; other site
640081010690	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
640081010691	leucine export protein LeuE; Provisional; Region: PRK10958
640081010692	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
640081010693	active site clefts [active]
640081010694	zinc binding site [ion binding]; other site
640081010695	dimer interface [polypeptide binding]; other site
640081010696	dihydrodipicolinate reductase; Region: dapB_plant; TIGR02130
640081010697	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
640081010698	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
640081010699	active site
640081010700	T5orf172 domain; Region: T5orf172; pfam10544
640081010701	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
640081010702	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
640081010703	FeS/SAM binding site; other site
640081010704	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
640081010705	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
640081010706	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
640081010707	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
640081010708	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
640081010709	4Fe-4S binding domain; Region: Fer4; cl02805
640081010710	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
640081010711	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
640081010712	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
640081010713	[4Fe-4S] binding site [ion binding]; other site
640081010714	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
640081010715	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
640081010716	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
640081010717	molybdopterin cofactor binding site; other site
640081010718	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
640081010719	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
640081010720	SEFIR domain; Region: SEFIR; pfam08357
640081010721	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081010722	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081010723	dimerization interface [polypeptide binding]; other site
640081010724	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081010725	dimer interface [polypeptide binding]; other site
640081010726	phosphorylation site [posttranslational modification]
640081010727	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081010728	ATP binding site [chemical binding]; other site
640081010729	Mg2+ binding site [ion binding]; other site
640081010730	G-X-G motif; other site
640081010731	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
640081010732	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081010733	active site
640081010734	phosphorylation site [posttranslational modification]
640081010735	intermolecular recognition site; other site
640081010736	dimerization interface [polypeptide binding]; other site
640081010737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081010738	Walker A motif; other site
640081010739	ATP binding site [chemical binding]; other site
640081010740	Walker B motif; other site
640081010741	arginine finger; other site
640081010742	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081010743	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
640081010744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081010745	active site
640081010746	phosphorylation site [posttranslational modification]
640081010747	intermolecular recognition site; other site
640081010748	dimerization interface [polypeptide binding]; other site
640081010749	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
640081010750	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
640081010751	anti sigma factor interaction site; other site
640081010752	regulatory phosphorylation site [posttranslational modification]; other site
640081010753	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
640081010754	hydrophobic ligand binding site; other site
640081010755	Chorismate lyase; Region: Chor_lyase; cl01230
640081010756	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
640081010757	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
640081010758	pseudouridine synthase; Region: TIGR00093
640081010759	active site
640081010760	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
640081010761	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
640081010762	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
640081010763	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
640081010764	isocitrate dehydrogenase; Validated; Region: PRK07362
640081010765	isocitrate dehydrogenase; Reviewed; Region: PRK07006
640081010766	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
640081010767	dimer interface [polypeptide binding]; other site
640081010768	FMN binding site [chemical binding]; other site
640081010769	putative cation:proton antiport protein; Provisional; Region: PRK10669
640081010770	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
640081010771	TrkA-N domain; Region: TrkA_N; pfam02254
640081010772	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
640081010773	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
640081010774	catalytic residues [active]
640081010775	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
640081010776	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
640081010777	NosL; Region: NosL; cl01769
640081010778	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
640081010779	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
640081010780	Walker A/P-loop; other site
640081010781	ATP binding site [chemical binding]; other site
640081010782	Q-loop/lid; other site
640081010783	ABC transporter signature motif; other site
640081010784	Walker B; other site
640081010785	D-loop; other site
640081010786	H-loop/switch region; other site
640081010787	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
640081010788	4Fe-4S binding domain; Region: Fer4_5; pfam12801
640081010789	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
640081010790	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
640081010791	4Fe-4S binding domain; Region: Fer4; pfam00037
640081010792	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
640081010793	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
640081010794	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
640081010795	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
640081010796	Cytochrome c; Region: Cytochrom_C; cl11414
640081010797	Cytochrome c; Region: Cytochrom_C; cl11414
640081010798	Cytochrome c; Region: Cytochrom_C; cl11414
640081010799	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
640081010800	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
640081010801	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
640081010802	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
640081010803	Cu(I) binding site [ion binding]; other site
640081010804	Protein of unknown function (DUF461); Region: DUF461; pfam04314
640081010805	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
640081010806	TolR protein; Region: tolR; TIGR02801
640081010807	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
640081010808	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
640081010809	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
640081010810	Cytochrome c; Region: Cytochrom_C; cl11414
640081010811	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
640081010812	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
640081010813	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
640081010814	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
640081010815	active site
640081010816	SAM binding site [chemical binding]; other site
640081010817	homodimer interface [polypeptide binding]; other site
640081010818	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
640081010819	UbiA prenyltransferase family; Region: UbiA; pfam01040
640081010820	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
640081010821	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
640081010822	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
640081010823	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
640081010824	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
640081010825	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
640081010826	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
640081010827	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
640081010828	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
640081010829	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
640081010830	Protein export membrane protein; Region: SecD_SecF; pfam02355
640081010831	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
640081010832	Cytochrome C' Region: Cytochrom_C_2; pfam01322
640081010833	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
640081010834	adenylosuccinate lyase; Provisional; Region: PRK09285
640081010835	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
640081010836	tetramer interface [polypeptide binding]; other site
640081010837	active site
640081010838	putative glutathione S-transferase; Provisional; Region: PRK10357
640081010839	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
640081010840	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
640081010841	dimer interface [polypeptide binding]; other site
640081010842	N-terminal domain interface [polypeptide binding]; other site
640081010843	putative substrate binding pocket (H-site) [chemical binding]; other site
640081010844	Response regulator receiver domain; Region: Response_reg; pfam00072
640081010845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081010846	active site
640081010847	phosphorylation site [posttranslational modification]
640081010848	intermolecular recognition site; other site
640081010849	dimerization interface [polypeptide binding]; other site
640081010850	Response regulator receiver domain; Region: Response_reg; pfam00072
640081010851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081010852	active site
640081010853	phosphorylation site [posttranslational modification]
640081010854	intermolecular recognition site; other site
640081010855	dimerization interface [polypeptide binding]; other site
640081010856	response regulator PleD; Reviewed; Region: pleD; PRK09581
640081010857	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081010858	active site
640081010859	phosphorylation site [posttranslational modification]
640081010860	intermolecular recognition site; other site
640081010861	dimerization interface [polypeptide binding]; other site
640081010862	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081010863	putative active site [active]
640081010864	heme pocket [chemical binding]; other site
640081010865	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081010866	metal binding site [ion binding]; metal-binding site
640081010867	active site
640081010868	I-site; other site
640081010869	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081010870	Response regulator receiver domain; Region: Response_reg; pfam00072
640081010871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081010872	active site
640081010873	phosphorylation site [posttranslational modification]
640081010874	intermolecular recognition site; other site
640081010875	dimerization interface [polypeptide binding]; other site
640081010876	Response regulator receiver domain; Region: Response_reg; pfam00072
640081010877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081010878	active site
640081010879	phosphorylation site [posttranslational modification]
640081010880	intermolecular recognition site; other site
640081010881	dimerization interface [polypeptide binding]; other site
640081010882	Response regulator receiver domain; Region: Response_reg; pfam00072
640081010883	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081010884	active site
640081010885	phosphorylation site [posttranslational modification]
640081010886	intermolecular recognition site; other site
640081010887	dimerization interface [polypeptide binding]; other site
640081010888	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
640081010889	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
640081010890	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
640081010891	nudix motif; other site
640081010892	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
640081010893	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
640081010894	homodimer interface [polypeptide binding]; other site
640081010895	substrate-cofactor binding pocket; other site
640081010896	catalytic residue [active]
640081010897	Zinc-finger domain; Region: zf-CHCC; cl01821
640081010898	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
640081010899	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
640081010900	putative active site [active]
640081010901	SnoaL-like domain; Region: SnoaL_3; pfam13474
640081010902	SnoaL-like domain; Region: SnoaL_2; pfam12680
640081010903	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
640081010904	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
640081010905	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
640081010906	active site
640081010907	substrate binding site [chemical binding]; other site
640081010908	metal binding site [ion binding]; metal-binding site
640081010909	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
640081010910	EAL domain; Region: EAL; pfam00563
640081010911	EAL domain; Region: EAL; pfam00563
640081010912	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
640081010913	Coenzyme A binding pocket [chemical binding]; other site
640081010914	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
640081010915	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
640081010916	nudix motif; other site
640081010917	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
640081010918	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
640081010919	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081010920	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081010921	ligand binding site [chemical binding]; other site
640081010922	flexible hinge region; other site
640081010923	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
640081010924	non-specific DNA interactions [nucleotide binding]; other site
640081010925	DNA binding site [nucleotide binding]
640081010926	sequence specific DNA binding site [nucleotide binding]; other site
640081010927	putative cAMP binding site [chemical binding]; other site
640081010928	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
640081010929	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
640081010930	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
640081010931	DNA methylase; Region: N6_N4_Mtase; pfam01555
640081010932	DNA methylase; Region: N6_N4_Mtase; pfam01555
640081010933	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
640081010934	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
640081010935	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081010936	Walker A motif; other site
640081010937	ATP binding site [chemical binding]; other site
640081010938	Walker B motif; other site
640081010939	arginine finger; other site
640081010940	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
640081010941	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
640081010942	putative active site [active]
640081010943	putative metal binding site [ion binding]; other site
640081010944	Poxvirus F12L protein; Region: Pox_F12L; cl17790
640081010945	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
640081010946	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
640081010947	motif 1; other site
640081010948	active site
640081010949	motif 2; other site
640081010950	motif 3; other site
640081010951	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
640081010952	DHHA1 domain; Region: DHHA1; pfam02272
640081010953	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
640081010954	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
640081010955	active site
640081010956	catalytic site [active]
640081010957	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
640081010958	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
640081010959	Amino acid permease; Region: AA_permease_2; pfam13520
640081010960	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
640081010961	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
640081010962	FAD binding site [chemical binding]; other site
640081010963	substrate binding pocket [chemical binding]; other site
640081010964	catalytic base [active]
640081010965	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
640081010966	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
640081010967	active site
640081010968	catalytic tetrad [active]
640081010969	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
640081010970	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
640081010971	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
640081010972	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081010973	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081010974	ligand binding site [chemical binding]; other site
640081010975	flexible hinge region; other site
640081010976	methionine aminotransferase; Validated; Region: PRK09082
640081010977	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
640081010978	pyridoxal 5'-phosphate binding site [chemical binding]; other site
640081010979	homodimer interface [polypeptide binding]; other site
640081010980	catalytic residue [active]
640081010981	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
640081010982	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
640081010983	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
640081010984	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
640081010985	intersubunit interface [polypeptide binding]; other site
640081010986	active site
640081010987	Zn2+ binding site [ion binding]; other site
640081010988	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
640081010989	Ligand Binding Site [chemical binding]; other site
640081010990	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
640081010991	Ligand Binding Site [chemical binding]; other site
640081010992	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
640081010993	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
640081010994	ligand binding site [chemical binding]; other site
640081010995	flexible hinge region; other site
640081010996	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
640081010997	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
640081010998	putative cation:proton antiport protein; Provisional; Region: PRK10669
640081010999	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
640081011000	TrkA-N domain; Region: TrkA_N; pfam02254
640081011001	TrkA-C domain; Region: TrkA_C; pfam02080
640081011002	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
640081011003	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
640081011004	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081011005	active site
640081011006	phosphorylation site [posttranslational modification]
640081011007	intermolecular recognition site; other site
640081011008	dimerization interface [polypeptide binding]; other site
640081011009	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
640081011010	dimerization interface [polypeptide binding]; other site
640081011011	DNA binding residues [nucleotide binding]
640081011012	MASE1; Region: MASE1; cl17823
640081011013	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081011014	ATP binding site [chemical binding]; other site
640081011015	Mg2+ binding site [ion binding]; other site
640081011016	G-X-G motif; other site
640081011017	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
640081011018	methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423
640081011019	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
640081011020	substrate binding site [chemical binding]; other site
640081011021	oxyanion hole (OAH) forming residues; other site
640081011022	trimer interface [polypeptide binding]; other site
640081011023	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
640081011024	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
640081011025	catalytic triad [active]
640081011026	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
640081011027	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
640081011028	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
640081011029	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
640081011030	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
640081011031	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
640081011032	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
640081011033	motif II; other site
640081011034	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
640081011035	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081011036	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081011037	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
640081011038	putative dimerization interface [polypeptide binding]; other site
640081011039	Protein of unknown function (DUF1780); Region: DUF1780; pfam08682
640081011040	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
640081011041	Helix-turn-helix domain; Region: HTH_38; pfam13936
640081011042	Homeodomain-like domain; Region: HTH_32; pfam13565
640081011043	Integrase core domain; Region: rve; pfam00665
640081011044	protease TldD; Provisional; Region: tldD; PRK10735
640081011045	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
640081011046	nitrilase; Region: PLN02798
640081011047	putative active site [active]
640081011048	catalytic triad [active]
640081011049	dimer interface [polypeptide binding]; other site
640081011050	TIGR02099 family protein; Region: TIGR02099
640081011051	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
640081011052	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
640081011053	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
640081011054	metal binding triad; other site
640081011055	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
640081011056	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
640081011057	metal binding triad; other site
640081011058	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
640081011059	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
640081011060	ATP binding site [chemical binding]; other site
640081011061	Mg++ binding site [ion binding]; other site
640081011062	motif III; other site
640081011063	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
640081011064	nucleotide binding region [chemical binding]; other site
640081011065	ATP-binding site [chemical binding]; other site
640081011066	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
640081011067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
640081011068	S-adenosylmethionine binding site [chemical binding]; other site
640081011069	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
640081011070	active site
640081011071	HDOD domain; Region: HDOD; pfam08668
640081011072	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
640081011073	Cysteine-rich domain; Region: CCG; pfam02754
640081011074	Cysteine-rich domain; Region: CCG; pfam02754
640081011075	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
640081011076	FAD binding domain; Region: FAD_binding_4; pfam01565
640081011077	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
640081011078	FAD binding domain; Region: FAD_binding_4; pfam01565
640081011079	Transcriptional regulators [Transcription]; Region: FadR; COG2186
640081011080	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
640081011081	DNA-binding site [nucleotide binding]; DNA binding site
640081011082	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
640081011083	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081011084	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081011085	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
640081011086	putative dimerization interface [polypeptide binding]; other site
640081011087	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
640081011088	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
640081011089	MOFRL family; Region: MOFRL; pfam05161
640081011090	Hemerythrin; Region: Hemerythrin; cd12107
640081011091	Fe binding site [ion binding]; other site
640081011092	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
640081011093	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
640081011094	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
640081011095	homotrimer interaction site [polypeptide binding]; other site
640081011096	putative active site [active]
640081011097	Transcriptional regulator [Transcription]; Region: LysR; COG0583
640081011098	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
640081011099	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
640081011100	dimerization interface [polypeptide binding]; other site
640081011101	Isochorismatase family; Region: Isochorismatase; pfam00857
640081011102	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
640081011103	catalytic triad [active]
640081011104	conserved cis-peptide bond; other site
640081011105	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
640081011106	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
640081011107	conserved cys residue [active]
640081011108	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
640081011109	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
640081011110	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081011111	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
640081011112	Protein of unknown function (DUF3240); Region: DUF3240; pfam11582
640081011113	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
640081011114	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
640081011115	Coenzyme A binding pocket [chemical binding]; other site
640081011116	hypothetical protein; Provisional; Region: PRK13687
640081011117	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
640081011118	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
640081011119	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
640081011120	PAS fold; Region: PAS_3; pfam08447
640081011121	putative active site [active]
640081011122	heme pocket [chemical binding]; other site
640081011123	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081011124	PAS fold; Region: PAS_3; pfam08447
640081011125	putative active site [active]
640081011126	heme pocket [chemical binding]; other site
640081011127	PAS domain S-box; Region: sensory_box; TIGR00229
640081011128	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081011129	PAS domain; Region: PAS_9; pfam13426
640081011130	putative active site [active]
640081011131	heme pocket [chemical binding]; other site
640081011132	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081011133	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081011134	metal binding site [ion binding]; metal-binding site
640081011135	active site
640081011136	I-site; other site
640081011137	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
640081011138	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
640081011139	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
640081011140	dimerization interface [polypeptide binding]; other site
640081011141	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
640081011142	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081011143	dimer interface [polypeptide binding]; other site
640081011144	putative CheW interface [polypeptide binding]; other site
640081011145	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
640081011146	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
640081011147	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
640081011148	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
640081011149	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
640081011150	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081011151	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
640081011152	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
640081011153	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
640081011154	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
640081011155	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
640081011156	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081011157	dimer interface [polypeptide binding]; other site
640081011158	phosphorylation site [posttranslational modification]
640081011159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081011160	ATP binding site [chemical binding]; other site
640081011161	Mg2+ binding site [ion binding]; other site
640081011162	G-X-G motif; other site
640081011163	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
640081011164	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081011165	active site
640081011166	phosphorylation site [posttranslational modification]
640081011167	intermolecular recognition site; other site
640081011168	dimerization interface [polypeptide binding]; other site
640081011169	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081011170	DNA binding site [nucleotide binding]
640081011171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081011172	Response regulator receiver domain; Region: Response_reg; pfam00072
640081011173	active site
640081011174	phosphorylation site [posttranslational modification]
640081011175	intermolecular recognition site; other site
640081011176	dimerization interface [polypeptide binding]; other site
640081011177	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081011178	PAS domain; Region: PAS_9; pfam13426
640081011179	putative active site [active]
640081011180	heme pocket [chemical binding]; other site
640081011181	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
640081011182	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
640081011183	metal binding site [ion binding]; metal-binding site
640081011184	active site
640081011185	I-site; other site
640081011186	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
640081011187	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
640081011188	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
640081011189	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
640081011190	D-galactonate transporter; Region: 2A0114; TIGR00893
640081011191	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
640081011192	putative substrate translocation pore; other site
640081011193	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
640081011194	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
640081011195	active site
640081011196	HIGH motif; other site
640081011197	nucleotide binding site [chemical binding]; other site
640081011198	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
640081011199	PhosphatidylEthanolamine-Binding Protein (PEBP) domain; Region: PEBP; cl00227
640081011200	substrate binding site [chemical binding]; other site
640081011201	HAMP domain; Region: HAMP; pfam00672
640081011202	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
640081011203	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
640081011204	NAD(P) binding site [chemical binding]; other site
640081011205	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
640081011206	potassium uptake protein; Region: kup; TIGR00794
640081011207	septum formation inhibitor; Reviewed; Region: PRK01973
640081011208	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
640081011209	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
640081011210	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
640081011211	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
640081011212	Switch I; other site
640081011213	Switch II; other site
640081011214	cell division topological specificity factor MinE; Provisional; Region: PRK13989
640081011215	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
640081011216	binding surface
640081011217	TPR motif; other site
640081011218	Tetratricopeptide repeat; Region: TPR_9; pfam13371
640081011219	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
640081011220	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
640081011221	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
640081011222	substrate binding pocket [chemical binding]; other site
640081011223	membrane-bound complex binding site; other site
640081011224	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
640081011225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
640081011226	putative PBP binding loops; other site
640081011227	dimer interface [polypeptide binding]; other site
640081011228	ABC-ATPase subunit interface; other site
640081011229	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
640081011230	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
640081011231	Walker A/P-loop; other site
640081011232	ATP binding site [chemical binding]; other site
640081011233	Q-loop/lid; other site
640081011234	ABC transporter signature motif; other site
640081011235	Walker B; other site
640081011236	D-loop; other site
640081011237	H-loop/switch region; other site
640081011238	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
640081011239	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081011240	dimer interface [polypeptide binding]; other site
640081011241	phosphorylation site [posttranslational modification]
640081011242	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081011243	ATP binding site [chemical binding]; other site
640081011244	Mg2+ binding site [ion binding]; other site
640081011245	G-X-G motif; other site
640081011246	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
640081011247	putative substrate binding pocket [chemical binding]; other site
640081011248	trimer interface [polypeptide binding]; other site
640081011249	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
640081011250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081011251	active site
640081011252	phosphorylation site [posttranslational modification]
640081011253	intermolecular recognition site; other site
640081011254	dimerization interface [polypeptide binding]; other site
640081011255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081011256	Walker A motif; other site
640081011257	ATP binding site [chemical binding]; other site
640081011258	Walker B motif; other site
640081011259	arginine finger; other site
640081011260	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081011261	Response regulator receiver domain; Region: Response_reg; pfam00072
640081011262	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081011263	active site
640081011264	phosphorylation site [posttranslational modification]
640081011265	intermolecular recognition site; other site
640081011266	dimerization interface [polypeptide binding]; other site
640081011267	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
640081011268	Histidine kinase; Region: HisKA_3; pfam07730
640081011269	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081011270	ATP binding site [chemical binding]; other site
640081011271	Mg2+ binding site [ion binding]; other site
640081011272	G-X-G motif; other site
640081011273	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
640081011274	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081011275	active site
640081011276	phosphorylation site [posttranslational modification]
640081011277	intermolecular recognition site; other site
640081011278	dimerization interface [polypeptide binding]; other site
640081011279	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
640081011280	DNA binding residues [nucleotide binding]
640081011281	dimerization interface [polypeptide binding]; other site
640081011282	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
640081011283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081011284	active site
640081011285	phosphorylation site [posttranslational modification]
640081011286	intermolecular recognition site; other site
640081011287	dimerization interface [polypeptide binding]; other site
640081011288	Response regulator receiver domain; Region: Response_reg; pfam00072
640081011289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081011290	active site
640081011291	phosphorylation site [posttranslational modification]
640081011292	intermolecular recognition site; other site
640081011293	dimerization interface [polypeptide binding]; other site
640081011294	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
640081011295	anti sigma factor interaction site; other site
640081011296	regulatory phosphorylation site [posttranslational modification]; other site
640081011297	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
640081011298	putative binding surface; other site
640081011299	active site
640081011300	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
640081011301	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
640081011302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081011303	ATP binding site [chemical binding]; other site
640081011304	Mg2+ binding site [ion binding]; other site
640081011305	G-X-G motif; other site
640081011306	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
640081011307	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
640081011308	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
640081011309	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
640081011310	dimer interface [polypeptide binding]; other site
640081011311	putative CheW interface [polypeptide binding]; other site
640081011312	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
640081011313	putative CheA interaction surface; other site
640081011314	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
640081011315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
640081011316	putative active site [active]
640081011317	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081011318	dimer interface [polypeptide binding]; other site
640081011319	phosphorylation site [posttranslational modification]
640081011320	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081011321	ATP binding site [chemical binding]; other site
640081011322	Mg2+ binding site [ion binding]; other site
640081011323	G-X-G motif; other site
640081011324	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
640081011325	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
640081011326	dimer interface [polypeptide binding]; other site
640081011327	ssDNA binding site [nucleotide binding]; other site
640081011328	tetramer (dimer of dimers) interface [polypeptide binding]; other site
640081011329	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
640081011330	Major Facilitator Superfamily; Region: MFS_1; pfam07690
640081011331	putative substrate translocation pore; other site
640081011332	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
640081011333	Aspartase; Region: Aspartase; cd01357
640081011334	active sites [active]
640081011335	tetramer interface [polypeptide binding]; other site
640081011336	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
640081011337	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
640081011338	GlpM protein; Region: GlpM; cl01212
640081011339	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
640081011340	hypothetical protein; Provisional; Region: PRK10621
640081011341	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
640081011342	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
640081011343	dimer interface [polypeptide binding]; other site
640081011344	phosphorylation site [posttranslational modification]
640081011345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081011346	ATP binding site [chemical binding]; other site
640081011347	Mg2+ binding site [ion binding]; other site
640081011348	G-X-G motif; other site
640081011349	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
640081011350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081011351	active site
640081011352	phosphorylation site [posttranslational modification]
640081011353	intermolecular recognition site; other site
640081011354	dimerization interface [polypeptide binding]; other site
640081011355	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
640081011356	Walker A motif; other site
640081011357	ATP binding site [chemical binding]; other site
640081011358	Walker B motif; other site
640081011359	arginine finger; other site
640081011360	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
640081011361	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
640081011362	Type II transport protein GspH; Region: GspH; pfam12019
640081011363	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
640081011364	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
640081011365	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
640081011366	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
640081011367	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
640081011368	Gram-negative bacterial tonB protein; Region: TonB; cl10048
640081011369	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
640081011370	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
640081011371	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
640081011372	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
640081011373	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
640081011374	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
640081011375	Moco binding site; other site
640081011376	metal coordination site [ion binding]; other site
640081011377	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
640081011378	lipoprotein signal peptidase; Provisional; Region: PRK14787
640081011379	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
640081011380	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
640081011381	active site
640081011382	HIGH motif; other site
640081011383	nucleotide binding site [chemical binding]; other site
640081011384	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
640081011385	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
640081011386	active site
640081011387	KMSKS motif; other site
640081011388	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
640081011389	tRNA binding surface [nucleotide binding]; other site
640081011390	anticodon binding site; other site
640081011391	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
640081011392	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
640081011393	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
640081011394	active site
640081011395	Riboflavin kinase; Region: Flavokinase; smart00904
640081011396	AMIN domain; Region: AMIN; pfam11741
640081011397	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
640081011398	active site
640081011399	metal binding site [ion binding]; metal-binding site
640081011400	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
640081011401	epoxyqueuosine reductase; Region: TIGR00276
640081011402	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
640081011403	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
640081011404	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
640081011405	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
640081011406	active site residue [active]
640081011407	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
640081011408	active site residue [active]
640081011409	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
640081011410	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
640081011411	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
640081011412	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
640081011413	[2Fe-2S] cluster binding site [ion binding]; other site
640081011414	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
640081011415	alpha subunit interface [polypeptide binding]; other site
640081011416	active site
640081011417	substrate binding site [chemical binding]; other site
640081011418	Fe binding site [ion binding]; other site
640081011419	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
640081011420	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
640081011421	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
640081011422	substrate binding pocket [chemical binding]; other site
640081011423	chain length determination region; other site
640081011424	substrate-Mg2+ binding site; other site
640081011425	catalytic residues [active]
640081011426	aspartate-rich region 1; other site
640081011427	active site lid residues [active]
640081011428	aspartate-rich region 2; other site
640081011429	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
640081011430	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
640081011431	TPP-binding site; other site
640081011432	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
640081011433	PYR/PP interface [polypeptide binding]; other site
640081011434	dimer interface [polypeptide binding]; other site
640081011435	TPP binding site [chemical binding]; other site
640081011436	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
640081011437	putative GTP cyclohydrolase; Provisional; Region: PRK13674
640081011438	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
640081011439	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
640081011440	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
640081011441	RimM N-terminal domain; Region: RimM; pfam01782
640081011442	PRC-barrel domain; Region: PRC; pfam05239
640081011443	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
640081011444	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
640081011445	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
640081011446	2-isopropylmalate synthase; Validated; Region: PRK00915
640081011447	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
640081011448	active site
640081011449	catalytic residues [active]
640081011450	metal binding site [ion binding]; metal-binding site
640081011451	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
640081011452	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
640081011453	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
640081011454	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
640081011455	HlyD family secretion protein; Region: HlyD_3; pfam13437
640081011456	Outer membrane efflux protein; Region: OEP; pfam02321
640081011457	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
640081011458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
640081011459	active site
640081011460	phosphorylation site [posttranslational modification]
640081011461	intermolecular recognition site; other site
640081011462	dimerization interface [polypeptide binding]; other site
640081011463	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
640081011464	DNA binding site [nucleotide binding]
640081011465	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
640081011466	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
640081011467	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
640081011468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
640081011469	ATP binding site [chemical binding]; other site
640081011470	Mg2+ binding site [ion binding]; other site
640081011471	G-X-G motif; other site
640081011472	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
640081011473	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
640081011474	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
640081011475	ketol-acid reductoisomerase; Provisional; Region: PRK05479
640081011476	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
640081011477	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
640081011478	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
640081011479	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
640081011480	putative valine binding site [chemical binding]; other site
640081011481	dimer interface [polypeptide binding]; other site
640081011482	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
640081011483	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
640081011484	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
640081011485	PYR/PP interface [polypeptide binding]; other site
640081011486	dimer interface [polypeptide binding]; other site
640081011487	TPP binding site [chemical binding]; other site
640081011488	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
640081011489	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
640081011490	TPP-binding site [chemical binding]; other site
640081011491	dimer interface [polypeptide binding]; other site
640081011492	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
640081011493	RNA polymerase factor sigma-70; Validated; Region: PRK09047
640081011494	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
640081011495	DNA binding residues [nucleotide binding]
640081011496	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
640081011497	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
640081011498	RDD family; Region: RDD; pfam06271
640081011499	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
640081011500	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
640081011501	Predicted permeases [General function prediction only]; Region: COG0795
640081011502	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
640081011503	multifunctional aminopeptidase A; Provisional; Region: PRK00913
640081011504	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
640081011505	interface (dimer of trimers) [polypeptide binding]; other site
640081011506	Substrate-binding/catalytic site; other site
640081011507	Zn-binding sites [ion binding]; other site
640081011508	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
640081011509	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
640081011510	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
640081011511	HIGH motif; other site
640081011512	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
640081011513	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
640081011514	active site
640081011515	KMSKS motif; other site
640081011516	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
640081011517	tRNA binding surface [nucleotide binding]; other site
640081011518	anticodon binding site; other site
640081011519	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458