-- dump date   	20140619_055625
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
639282000001	DNA polymerase III subunit beta; Validated; Region: PRK05643
639282000002	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
639282000003	putative DNA binding surface [nucleotide binding]; other site
639282000004	dimer interface [polypeptide binding]; other site
639282000005	beta-clamp/clamp loader binding surface; other site
639282000006	beta-clamp/translesion DNA polymerase binding surface; other site
639282000007	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
639282000008	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282000009	Walker A/P-loop; other site
639282000010	ATP binding site [chemical binding]; other site
639282000011	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
639282000012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282000013	ATP binding site [chemical binding]; other site
639282000014	Mg2+ binding site [ion binding]; other site
639282000015	G-X-G motif; other site
639282000016	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
639282000017	anchoring element; other site
639282000018	dimer interface [polypeptide binding]; other site
639282000019	ATP binding site [chemical binding]; other site
639282000020	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
639282000021	active site
639282000022	metal binding site [ion binding]; metal-binding site
639282000023	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
639282000024	DNA gyrase subunit A; Validated; Region: PRK05560
639282000025	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
639282000026	CAP-like domain; other site
639282000027	active site
639282000028	primary dimer interface [polypeptide binding]; other site
639282000029	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
639282000030	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
639282000031	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
639282000032	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
639282000033	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
639282000034	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
639282000035	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
639282000036	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
639282000037	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
639282000038	homodimer interface [polypeptide binding]; other site
639282000039	NADP binding site [chemical binding]; other site
639282000040	substrate binding site [chemical binding]; other site
639282000041	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
639282000042	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
639282000043	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
639282000044	GTP/Mg2+ binding site [chemical binding]; other site
639282000045	G4 box; other site
639282000046	G5 box; other site
639282000047	trmE is a tRNA modification GTPase; Region: trmE; cd04164
639282000048	G1 box; other site
639282000049	G1 box; other site
639282000050	GTP/Mg2+ binding site [chemical binding]; other site
639282000051	Switch I region; other site
639282000052	Switch I region; other site
639282000053	G2 box; other site
639282000054	G2 box; other site
639282000055	Switch II region; other site
639282000056	G3 box; other site
639282000057	G4 box; other site
639282000058	G5 box; other site
639282000059	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
639282000060	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
639282000061	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
639282000062	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
639282000063	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
639282000064	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
639282000065	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
639282000066	metal-dependent hydrolase; Provisional; Region: PRK00685
639282000067	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
639282000068	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
639282000069	GAF domain; Region: GAF; pfam01590
639282000070	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282000071	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282000072	dimer interface [polypeptide binding]; other site
639282000073	phosphorylation site [posttranslational modification]
639282000074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282000075	ATP binding site [chemical binding]; other site
639282000076	Mg2+ binding site [ion binding]; other site
639282000077	G-X-G motif; other site
639282000078	Protein of unknown function (DUF342); Region: DUF342; pfam03961
639282000079	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
639282000080	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
639282000081	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
639282000082	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
639282000083	AMIN domain; Region: AMIN; pfam11741
639282000084	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
639282000085	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
639282000086	active site
639282000087	metal binding site [ion binding]; metal-binding site
639282000088	Family of unknown function (DUF490); Region: DUF490; pfam04357
639282000089	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
639282000090	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
639282000091	Surface antigen; Region: Bac_surface_Ag; pfam01103
639282000092	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
639282000093	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
639282000094	dimer interface [polypeptide binding]; other site
639282000095	decamer (pentamer of dimers) interface [polypeptide binding]; other site
639282000096	catalytic triad [active]
639282000097	peroxidatic and resolving cysteines [active]
639282000098	C-terminal domain of 1-Cys peroxiredoxin; Region: 1-cysPrx_C; pfam10417
639282000099	Rubrerythrin [Energy production and conversion]; Region: COG1592
639282000100	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
639282000101	binuclear metal center [ion binding]; other site
639282000102	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
639282000103	iron binding site [ion binding]; other site
639282000104	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
639282000105	AIR carboxylase; Region: AIRC; smart01001
639282000106	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
639282000107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282000108	S-adenosylmethionine binding site [chemical binding]; other site
639282000109	ribonuclease G; Provisional; Region: PRK11712
639282000110	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
639282000111	homodimer interface [polypeptide binding]; other site
639282000112	oligonucleotide binding site [chemical binding]; other site
639282000113	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
639282000114	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
639282000115	G1 box; other site
639282000116	GTP/Mg2+ binding site [chemical binding]; other site
639282000117	G2 box; other site
639282000118	Switch I region; other site
639282000119	G3 box; other site
639282000120	Switch II region; other site
639282000121	G4 box; other site
639282000122	G5 box; other site
639282000123	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
639282000124	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
639282000125	active site
639282000126	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
639282000127	active site 2 [active]
639282000128	active site 1 [active]
639282000129	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
639282000130	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
639282000131	Walker A/P-loop; other site
639282000132	ATP binding site [chemical binding]; other site
639282000133	Q-loop/lid; other site
639282000134	ABC transporter signature motif; other site
639282000135	Walker B; other site
639282000136	D-loop; other site
639282000137	H-loop/switch region; other site
639282000138	Cobalt transport protein; Region: CbiQ; cl00463
639282000139	cobalt transport protein CbiM; Validated; Region: PRK06265
639282000140	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
639282000141	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
639282000142	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
639282000143	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
639282000144	replicative DNA helicase; Region: DnaB; TIGR00665
639282000145	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
639282000146	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
639282000147	Walker A motif; other site
639282000148	ATP binding site [chemical binding]; other site
639282000149	Walker B motif; other site
639282000150	DNA binding loops [nucleotide binding]
639282000151	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
639282000152	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
639282000153	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
639282000154	RecX family; Region: RecX; cl00936
639282000155	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
639282000156	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
639282000157	ATP binding site [chemical binding]; other site
639282000158	Walker B motif; other site
639282000159	recombinase A; Provisional; Region: recA; PRK09354
639282000160	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
639282000161	hexamer interface [polypeptide binding]; other site
639282000162	Walker A motif; other site
639282000163	ATP binding site [chemical binding]; other site
639282000164	Walker B motif; other site
639282000165	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
639282000166	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
639282000167	competence damage-inducible protein A; Provisional; Region: PRK00549
639282000168	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
639282000169	putative MPT binding site; other site
639282000170	Competence-damaged protein; Region: CinA; pfam02464
639282000171	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
639282000172	tetramer interfaces [polypeptide binding]; other site
639282000173	binuclear metal-binding site [ion binding]; other site
639282000174	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
639282000175	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
639282000176	catalytic residues [active]
639282000177	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
639282000178	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
639282000179	putative active site [active]
639282000180	oxyanion strand; other site
639282000181	catalytic triad [active]
639282000182	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
639282000183	putative active site pocket [active]
639282000184	4-fold oligomerization interface [polypeptide binding]; other site
639282000185	metal binding residues [ion binding]; metal-binding site
639282000186	3-fold/trimer interface [polypeptide binding]; other site
639282000187	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
639282000188	heme-binding site [chemical binding]; other site
639282000189	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
639282000190	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
639282000191	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
639282000192	nucleotide binding region [chemical binding]; other site
639282000193	ATP-binding site [chemical binding]; other site
639282000194	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
639282000195	DHH family; Region: DHH; pfam01368
639282000196	DHHA1 domain; Region: DHHA1; pfam02272
639282000197	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
639282000198	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282000199	Zn2+ binding site [ion binding]; other site
639282000200	Mg2+ binding site [ion binding]; other site
639282000201	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
639282000202	synthetase active site [active]
639282000203	NTP binding site [chemical binding]; other site
639282000204	metal binding site [ion binding]; metal-binding site
639282000205	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
639282000206	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
639282000207	Uncharacterized conserved protein [Function unknown]; Region: COG1434
639282000208	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
639282000209	putative active site [active]
639282000210	elongation factor Ts; Reviewed; Region: tsf; PRK12332
639282000211	UBA/TS-N domain; Region: UBA; pfam00627
639282000212	Elongation factor TS; Region: EF_TS; pfam00889
639282000213	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
639282000214	rRNA interaction site [nucleotide binding]; other site
639282000215	S8 interaction site; other site
639282000216	putative laminin-1 binding site; other site
639282000217	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
639282000218	dimerization interface [polypeptide binding]; other site
639282000219	putative DNA binding site [nucleotide binding]; other site
639282000220	putative Zn2+ binding site [ion binding]; other site
639282000221	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
639282000222	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
639282000223	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
639282000224	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
639282000225	ligand binding site [chemical binding]; other site
639282000226	HlyD family secretion protein; Region: HlyD_3; pfam13437
639282000227	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
639282000228	Protein export membrane protein; Region: SecD_SecF; cl14618
639282000229	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
639282000230	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
639282000231	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
639282000232	metal binding triad [ion binding]; metal-binding site
639282000233	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
639282000234	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282000235	Zn2+ binding site [ion binding]; other site
639282000236	Mg2+ binding site [ion binding]; other site
639282000237	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
639282000238	active site
639282000239	metal binding site [ion binding]; metal-binding site
639282000240	homotetramer interface [polypeptide binding]; other site
639282000241	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
639282000242	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
639282000243	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
639282000244	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
639282000245	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
639282000246	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
639282000247	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
639282000248	intersubunit interface [polypeptide binding]; other site
639282000249	active site
639282000250	zinc binding site [ion binding]; other site
639282000251	Na+ binding site [ion binding]; other site
639282000252	Response regulator receiver domain; Region: Response_reg; pfam00072
639282000253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282000254	active site
639282000255	phosphorylation site [posttranslational modification]
639282000256	intermolecular recognition site; other site
639282000257	dimerization interface [polypeptide binding]; other site
639282000258	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
639282000259	active site
639282000260	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
639282000261	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
639282000262	active site
639282000263	HIGH motif; other site
639282000264	KMSKS motif; other site
639282000265	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
639282000266	anticodon binding site; other site
639282000267	tRNA binding surface [nucleotide binding]; other site
639282000268	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
639282000269	putative tRNA-binding site [nucleotide binding]; other site
639282000270	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
639282000271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282000272	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
639282000273	Walker A motif; other site
639282000274	ATP binding site [chemical binding]; other site
639282000275	Walker B motif; other site
639282000276	arginine finger; other site
639282000277	thymidylate kinase; Validated; Region: tmk; PRK00698
639282000278	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
639282000279	TMP-binding site; other site
639282000280	ATP-binding site [chemical binding]; other site
639282000281	MOSC domain; Region: MOSC; pfam03473
639282000282	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
639282000283	MPT binding site; other site
639282000284	trimer interface [polypeptide binding]; other site
639282000285	Predicted permeases [General function prediction only]; Region: COG0679
639282000286	transketolase; Reviewed; Region: PRK05899
639282000287	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
639282000288	TPP-binding site [chemical binding]; other site
639282000289	dimer interface [polypeptide binding]; other site
639282000290	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
639282000291	PYR/PP interface [polypeptide binding]; other site
639282000292	dimer interface [polypeptide binding]; other site
639282000293	TPP binding site [chemical binding]; other site
639282000294	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
639282000295	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
639282000296	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
639282000297	putative substrate-binding site; other site
639282000298	nickel binding site [ion binding]; other site
639282000299	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
639282000300	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
639282000301	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
639282000302	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
639282000303	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
639282000304	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
639282000305	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
639282000306	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
639282000307	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
639282000308	active site
639282000309	homodimer interface [polypeptide binding]; other site
639282000310	catalytic site [active]
639282000311	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
639282000312	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
639282000313	anti sigma factor interaction site; other site
639282000314	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
639282000315	regulatory phosphorylation site [posttranslational modification]; other site
639282000316	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
639282000317	PAS domain; Region: PAS_10; pfam13596
639282000318	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
639282000319	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
639282000320	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
639282000321	PhoU domain; Region: PhoU; pfam01895
639282000322	PhoU domain; Region: PhoU; pfam01895
639282000323	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
639282000324	Response regulator receiver domain; Region: Response_reg; pfam00072
639282000325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282000326	active site
639282000327	phosphorylation site [posttranslational modification]
639282000328	intermolecular recognition site; other site
639282000329	dimerization interface [polypeptide binding]; other site
639282000330	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282000331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282000332	dimer interface [polypeptide binding]; other site
639282000333	phosphorylation site [posttranslational modification]
639282000334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282000335	ATP binding site [chemical binding]; other site
639282000336	Mg2+ binding site [ion binding]; other site
639282000337	G-X-G motif; other site
639282000338	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
639282000339	active site
639282000340	multimer interface [polypeptide binding]; other site
639282000341	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
639282000342	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
639282000343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282000344	catalytic residue [active]
639282000345	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
639282000346	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
639282000347	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
639282000348	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
639282000349	Preprotein translocase subunit; Region: YajC; pfam02699
639282000350	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
639282000351	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
639282000352	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
639282000353	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
639282000354	Protein export membrane protein; Region: SecD_SecF; pfam02355
639282000355	transcription termination factor Rho; Provisional; Region: rho; PRK09376
639282000356	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
639282000357	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
639282000358	RNA binding site [nucleotide binding]; other site
639282000359	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
639282000360	multimer interface [polypeptide binding]; other site
639282000361	Walker A motif; other site
639282000362	ATP binding site [chemical binding]; other site
639282000363	Walker B motif; other site
639282000364	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
639282000365	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
639282000366	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
639282000367	peptide chain release factor 1; Validated; Region: prfA; PRK00591
639282000368	This domain is found in peptide chain release factors; Region: PCRF; smart00937
639282000369	RF-1 domain; Region: RF-1; pfam00472
639282000370	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
639282000371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282000372	S-adenosylmethionine binding site [chemical binding]; other site
639282000373	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
639282000374	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
639282000375	hinge; other site
639282000376	active site
639282000377	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
639282000378	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
639282000379	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
639282000380	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
639282000381	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
639282000382	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
639282000383	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
639282000384	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
639282000385	Surface antigen; Region: Bac_surface_Ag; pfam01103
639282000386	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
639282000387	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
639282000388	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
639282000389	trimer interface [polypeptide binding]; other site
639282000390	active site
639282000391	UDP-GlcNAc binding site [chemical binding]; other site
639282000392	lipid binding site [chemical binding]; lipid-binding site
639282000393	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
639282000394	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
639282000395	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
639282000396	active site
639282000397	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
639282000398	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
639282000399	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
639282000400	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
639282000401	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
639282000402	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
639282000403	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
639282000404	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
639282000405	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
639282000406	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
639282000407	active site
639282000408	HIGH motif; other site
639282000409	dimer interface [polypeptide binding]; other site
639282000410	KMSKS motif; other site
639282000411	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
639282000412	RNA binding surface [nucleotide binding]; other site
639282000413	Uncharacterized conserved protein [Function unknown]; Region: COG4198
639282000414	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
639282000415	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
639282000416	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
639282000417	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
639282000418	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
639282000419	GTP-binding protein LepA; Provisional; Region: PRK05433
639282000420	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
639282000421	G1 box; other site
639282000422	putative GEF interaction site [polypeptide binding]; other site
639282000423	GTP/Mg2+ binding site [chemical binding]; other site
639282000424	Switch I region; other site
639282000425	G2 box; other site
639282000426	G3 box; other site
639282000427	Switch II region; other site
639282000428	G4 box; other site
639282000429	G5 box; other site
639282000430	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
639282000431	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
639282000432	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
639282000433	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
639282000434	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
639282000435	Catalytic site [active]
639282000436	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
639282000437	putative nucleotide binding site [chemical binding]; other site
639282000438	uridine monophosphate binding site [chemical binding]; other site
639282000439	homohexameric interface [polypeptide binding]; other site
639282000440	ribosome recycling factor; Reviewed; Region: frr; PRK00083
639282000441	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
639282000442	hinge region; other site
639282000443	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
639282000444	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
639282000445	catalytic residue [active]
639282000446	putative FPP diphosphate  binding site; other site
639282000447	putative FPP binding hydrophobic cleft; other site
639282000448	dimer interface [polypeptide binding]; other site
639282000449	putative IPP diphosphate binding site; other site
639282000450	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
639282000451	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
639282000452	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
639282000453	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
639282000454	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
639282000455	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
639282000456	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
639282000457	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
639282000458	active site
639282000459	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
639282000460	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
639282000461	putative substrate binding region [chemical binding]; other site
639282000462	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
639282000463	active site
639282000464	catalytic site [active]
639282000465	substrate binding site [chemical binding]; other site
639282000466	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
639282000467	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
639282000468	P-loop; other site
639282000469	Magnesium ion binding site [ion binding]; other site
639282000470	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
639282000471	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
639282000472	ParB-like nuclease domain; Region: ParBc; pfam02195
639282000473	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
639282000474	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
639282000475	triosephosphate isomerase; Provisional; Region: PRK14567
639282000476	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
639282000477	substrate binding site [chemical binding]; other site
639282000478	dimer interface [polypeptide binding]; other site
639282000479	catalytic triad [active]
639282000480	Preprotein translocase SecG subunit; Region: SecG; pfam03840
639282000481	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
639282000482	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
639282000483	peptide binding site [polypeptide binding]; other site
639282000484	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
639282000485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282000486	dimer interface [polypeptide binding]; other site
639282000487	conserved gate region; other site
639282000488	putative PBP binding loops; other site
639282000489	ABC-ATPase subunit interface; other site
639282000490	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
639282000491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282000492	dimer interface [polypeptide binding]; other site
639282000493	conserved gate region; other site
639282000494	putative PBP binding loops; other site
639282000495	ABC-ATPase subunit interface; other site
639282000496	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
639282000497	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
639282000498	inhibitor-cofactor binding pocket; inhibition site
639282000499	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282000500	catalytic residue [active]
639282000501	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
639282000502	putative acyl-acceptor binding pocket; other site
639282000503	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
639282000504	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
639282000505	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
639282000506	putative acyl-acceptor binding pocket; other site
639282000507	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
639282000508	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
639282000509	active site
639282000510	motif I; other site
639282000511	motif II; other site
639282000512	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
639282000513	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
639282000514	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
639282000515	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
639282000516	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
639282000517	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282000518	Walker A motif; other site
639282000519	ATP binding site [chemical binding]; other site
639282000520	Walker B motif; other site
639282000521	DNA polymerase III subunit delta'; Validated; Region: PRK08485
639282000522	arginine finger; other site
639282000523	hypothetical protein; Validated; Region: PRK00153
639282000524	recombination protein RecR; Reviewed; Region: recR; PRK00076
639282000525	RecR protein; Region: RecR; pfam02132
639282000526	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
639282000527	putative active site [active]
639282000528	putative metal-binding site [ion binding]; other site
639282000529	tetramer interface [polypeptide binding]; other site
639282000530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282000531	S-adenosylmethionine binding site [chemical binding]; other site
639282000532	Response regulator receiver domain; Region: Response_reg; pfam00072
639282000533	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282000534	active site
639282000535	phosphorylation site [posttranslational modification]
639282000536	intermolecular recognition site; other site
639282000537	dimerization interface [polypeptide binding]; other site
639282000538	Sm and related proteins; Region: Sm_like; cl00259
639282000539	heptamer interface [polypeptide binding]; other site
639282000540	Sm1 motif; other site
639282000541	hexamer interface [polypeptide binding]; other site
639282000542	RNA binding site [nucleotide binding]; other site
639282000543	Sm2 motif; other site
639282000544	bacterial Hfq-like; Region: Hfq; cd01716
639282000545	hexamer interface [polypeptide binding]; other site
639282000546	Sm1 motif; other site
639282000547	RNA binding site [nucleotide binding]; other site
639282000548	Sm2 motif; other site
639282000549	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
639282000550	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
639282000551	putative phosphate acyltransferase; Provisional; Region: PRK05331
639282000552	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
639282000553	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
639282000554	dimer interface [polypeptide binding]; other site
639282000555	active site
639282000556	CoA binding pocket [chemical binding]; other site
639282000557	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
639282000558	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
639282000559	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
639282000560	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
639282000561	NAD(P) binding site [chemical binding]; other site
639282000562	homotetramer interface [polypeptide binding]; other site
639282000563	homodimer interface [polypeptide binding]; other site
639282000564	active site
639282000565	acyl carrier protein; Provisional; Region: acpP; PRK00982
639282000566	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
639282000567	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
639282000568	dimer interface [polypeptide binding]; other site
639282000569	active site
639282000570	ribonuclease III; Reviewed; Region: rnc; PRK00102
639282000571	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
639282000572	dimerization interface [polypeptide binding]; other site
639282000573	active site
639282000574	metal binding site [ion binding]; metal-binding site
639282000575	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
639282000576	dsRNA binding site [nucleotide binding]; other site
639282000577	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282000578	Radical SAM superfamily; Region: Radical_SAM; pfam04055
639282000579	FeS/SAM binding site; other site
639282000580	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
639282000581	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282000582	S-adenosylmethionine binding site [chemical binding]; other site
639282000583	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
639282000584	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
639282000585	active site
639282000586	(T/H)XGH motif; other site
639282000587	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
639282000588	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282000589	Zn2+ binding site [ion binding]; other site
639282000590	Mg2+ binding site [ion binding]; other site
639282000591	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
639282000592	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
639282000593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282000594	active site
639282000595	phosphorylation site [posttranslational modification]
639282000596	intermolecular recognition site; other site
639282000597	dimerization interface [polypeptide binding]; other site
639282000598	Response regulator receiver domain; Region: Response_reg; pfam00072
639282000599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282000600	active site
639282000601	phosphorylation site [posttranslational modification]
639282000602	intermolecular recognition site; other site
639282000603	dimerization interface [polypeptide binding]; other site
639282000604	CheW-like domain; Region: CheW; pfam01584
639282000605	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282000606	dimerization interface [polypeptide binding]; other site
639282000607	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282000608	dimerization interface [polypeptide binding]; other site
639282000609	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282000610	dimer interface [polypeptide binding]; other site
639282000611	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
639282000612	putative CheW interface [polypeptide binding]; other site
639282000613	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
639282000614	putative binding surface; other site
639282000615	active site
639282000616	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
639282000617	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282000618	ATP binding site [chemical binding]; other site
639282000619	Mg2+ binding site [ion binding]; other site
639282000620	G-X-G motif; other site
639282000621	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
639282000622	Response regulator receiver domain; Region: Response_reg; pfam00072
639282000623	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282000624	active site
639282000625	phosphorylation site [posttranslational modification]
639282000626	intermolecular recognition site; other site
639282000627	dimerization interface [polypeptide binding]; other site
639282000628	CheW-like domain; Region: CheW; pfam01584
639282000629	Response regulator receiver domain; Region: Response_reg; pfam00072
639282000630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282000631	active site
639282000632	phosphorylation site [posttranslational modification]
639282000633	intermolecular recognition site; other site
639282000634	dimerization interface [polypeptide binding]; other site
639282000635	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
639282000636	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
639282000637	dimerization interface [polypeptide binding]; other site
639282000638	putative ATP binding site [chemical binding]; other site
639282000639	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
639282000640	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
639282000641	active site
639282000642	substrate binding site [chemical binding]; other site
639282000643	cosubstrate binding site; other site
639282000644	catalytic site [active]
639282000645	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
639282000646	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
639282000647	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
639282000648	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
639282000649	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
639282000650	active site
639282000651	motif I; other site
639282000652	motif II; other site
639282000653	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
639282000654	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
639282000655	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
639282000656	CcmE; Region: CcmE; cl00994
639282000657	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
639282000658	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
639282000659	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
639282000660	Walker A/P-loop; other site
639282000661	ATP binding site [chemical binding]; other site
639282000662	Q-loop/lid; other site
639282000663	ABC transporter signature motif; other site
639282000664	Walker B; other site
639282000665	D-loop; other site
639282000666	H-loop/switch region; other site
639282000667	CcmB protein; Region: CcmB; cl17444
639282000668	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
639282000669	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
639282000670	dimerization interface [polypeptide binding]; other site
639282000671	putative DNA binding site [nucleotide binding]; other site
639282000672	putative Zn2+ binding site [ion binding]; other site
639282000673	hypothetical protein; Reviewed; Region: PRK12497
639282000674	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
639282000675	RNA/DNA hybrid binding site [nucleotide binding]; other site
639282000676	active site
639282000677	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
639282000678	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
639282000679	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
639282000680	hypothetical protein; Provisional; Region: PRK10621
639282000681	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
639282000682	Cysteine-rich small domain; Region: zf-like; cl00946
639282000683	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
639282000684	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
639282000685	dimer interface [polypeptide binding]; other site
639282000686	phosphorylation site [posttranslational modification]
639282000687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282000688	ATP binding site [chemical binding]; other site
639282000689	Mg2+ binding site [ion binding]; other site
639282000690	G-X-G motif; other site
639282000691	Response regulator receiver domain; Region: Response_reg; pfam00072
639282000692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282000693	active site
639282000694	phosphorylation site [posttranslational modification]
639282000695	intermolecular recognition site; other site
639282000696	dimerization interface [polypeptide binding]; other site
639282000697	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
639282000698	NAD-dependent deacetylase; Provisional; Region: PRK00481
639282000699	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
639282000700	NAD+ binding site [chemical binding]; other site
639282000701	substrate binding site [chemical binding]; other site
639282000702	Zn binding site [ion binding]; other site
639282000703	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
639282000704	nucleotide binding site/active site [active]
639282000705	HIT family signature motif; other site
639282000706	catalytic residue [active]
639282000707	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
639282000708	tetratricopeptide repeat protein; Provisional; Region: PRK11788
639282000709	trigger factor; Provisional; Region: tig; PRK01490
639282000710	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
639282000711	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
639282000712	Clp protease; Region: CLP_protease; pfam00574
639282000713	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
639282000714	oligomer interface [polypeptide binding]; other site
639282000715	active site residues [active]
639282000716	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
639282000717	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
639282000718	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282000719	Walker A motif; other site
639282000720	ATP binding site [chemical binding]; other site
639282000721	Walker B motif; other site
639282000722	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
639282000723	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
639282000724	Found in ATP-dependent protease La (LON); Region: LON; smart00464
639282000725	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282000726	Walker A motif; other site
639282000727	ATP binding site [chemical binding]; other site
639282000728	Walker B motif; other site
639282000729	arginine finger; other site
639282000730	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
639282000731	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
639282000732	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
639282000733	L-aspartate oxidase; Provisional; Region: PRK06175
639282000734	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
639282000735	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
639282000736	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282000737	Radical SAM superfamily; Region: Radical_SAM; pfam04055
639282000738	FeS/SAM binding site; other site
639282000739	enolase; Provisional; Region: eno; PRK00077
639282000740	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
639282000741	dimer interface [polypeptide binding]; other site
639282000742	metal binding site [ion binding]; metal-binding site
639282000743	substrate binding pocket [chemical binding]; other site
639282000744	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
639282000745	Peptidase family M23; Region: Peptidase_M23; pfam01551
639282000746	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
639282000747	Ligand Binding Site [chemical binding]; other site
639282000748	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
639282000749	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
639282000750	DRTGG domain; Region: DRTGG; pfam07085
639282000751	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
639282000752	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
639282000753	DHHA2 domain; Region: DHHA2; pfam02833
639282000754	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
639282000755	anti sigma factor interaction site; other site
639282000756	regulatory phosphorylation site [posttranslational modification]; other site
639282000757	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
639282000758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
639282000759	ATP binding site [chemical binding]; other site
639282000760	Mg2+ binding site [ion binding]; other site
639282000761	G-X-G motif; other site
639282000762	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
639282000763	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
639282000764	dimer interface [polypeptide binding]; other site
639282000765	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282000766	catalytic residue [active]
639282000767	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
639282000768	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
639282000769	homodimer interface [polypeptide binding]; other site
639282000770	substrate-cofactor binding pocket; other site
639282000771	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282000772	catalytic residue [active]
639282000773	Rrf2 family protein; Region: rrf2_super; TIGR00738
639282000774	Transcriptional regulator; Region: Rrf2; pfam02082
639282000775	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
639282000776	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
639282000777	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
639282000778	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
639282000779	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
639282000780	PilZ domain; Region: PilZ; pfam07238
639282000781	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
639282000782	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
639282000783	diaminopimelate decarboxylase; Region: lysA; TIGR01048
639282000784	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
639282000785	active site
639282000786	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
639282000787	substrate binding site [chemical binding]; other site
639282000788	catalytic residues [active]
639282000789	dimer interface [polypeptide binding]; other site
639282000790	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
639282000791	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
639282000792	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
639282000793	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
639282000794	dihydrodipicolinate synthase; Region: dapA; TIGR00674
639282000795	dimer interface [polypeptide binding]; other site
639282000796	active site
639282000797	catalytic residue [active]
639282000798	dihydrodipicolinate reductase; Provisional; Region: PRK00048
639282000799	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
639282000800	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
639282000801	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
639282000802	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
639282000803	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
639282000804	active site
639282000805	CBS domain; Region: CBS; pfam00571
639282000806	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
639282000807	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
639282000808	ThiS interaction site; other site
639282000809	putative active site [active]
639282000810	tetramer interface [polypeptide binding]; other site
639282000811	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
639282000812	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282000813	FeS/SAM binding site; other site
639282000814	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
639282000815	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
639282000816	TRAM domain; Region: TRAM; cl01282
639282000817	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
639282000818	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
639282000819	DNA binding site [nucleotide binding]
639282000820	active site
639282000821	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
639282000822	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
639282000823	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282000824	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282000825	metal binding site [ion binding]; metal-binding site
639282000826	active site
639282000827	I-site; other site
639282000828	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
639282000829	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
639282000830	putative active site [active]
639282000831	PhoH-like protein; Region: PhoH; pfam02562
639282000832	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
639282000833	dimer interface [polypeptide binding]; other site
639282000834	active site
639282000835	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
639282000836	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
639282000837	active site
639282000838	nucleotide binding site [chemical binding]; other site
639282000839	HIGH motif; other site
639282000840	KMSKS motif; other site
639282000841	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
639282000842	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
639282000843	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
639282000844	ATP binding site [chemical binding]; other site
639282000845	putative Mg++ binding site [ion binding]; other site
639282000846	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
639282000847	nucleotide binding region [chemical binding]; other site
639282000848	ATP-binding site [chemical binding]; other site
639282000849	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
639282000850	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
639282000851	SurA N-terminal domain; Region: SurA_N; pfam09312
639282000852	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
639282000853	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
639282000854	RNA binding surface [nucleotide binding]; other site
639282000855	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
639282000856	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
639282000857	ligand binding site [chemical binding]; other site
639282000858	flexible hinge region; other site
639282000859	fumarate hydratase; Reviewed; Region: fumC; PRK00485
639282000860	Class II fumarases; Region: Fumarase_classII; cd01362
639282000861	active site
639282000862	tetramer interface [polypeptide binding]; other site
639282000863	pyruvate phosphate dikinase; Provisional; Region: PRK09279
639282000864	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
639282000865	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
639282000866	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
639282000867	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
639282000868	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
639282000869	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
639282000870	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
639282000871	substrate binding site [chemical binding]; other site
639282000872	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
639282000873	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
639282000874	substrate binding site [chemical binding]; other site
639282000875	ligand binding site [chemical binding]; other site
639282000876	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
639282000877	oligomerisation interface [polypeptide binding]; other site
639282000878	mobile loop; other site
639282000879	roof hairpin; other site
639282000880	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
639282000881	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
639282000882	ring oligomerisation interface [polypeptide binding]; other site
639282000883	ATP/Mg binding site [chemical binding]; other site
639282000884	stacking interactions; other site
639282000885	hinge regions; other site
639282000886	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
639282000887	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
639282000888	Pseudogene. Similar to aldehyde ferredoxin oxidoreductase. This CDS is disrupted by the insertion of IS element.
639282000889	Pseudogene. Similar to the C terminus of aldehyde ferredoxin oxidoreductase. This CDS is divided by IS element
639282000890	Transposase, Mutator family; Region: Transposase_mut; pfam00872
639282000891	MULE transposase domain; Region: MULE; pfam10551
639282000892	Pseudogene. Similar to the N terminus of aldehyde ferredoxin oxidoreductase. This CDS is divided by IS element
639282000893	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
639282000894	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
639282000895	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
639282000896	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
639282000897	23S rRNA interface [nucleotide binding]; other site
639282000898	L3 interface [polypeptide binding]; other site
639282000899	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
639282000900	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
639282000901	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
639282000902	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
639282000903	RimM N-terminal domain; Region: RimM; pfam01782
639282000904	PRC-barrel domain; Region: PRC; pfam05239
639282000905	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
639282000906	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
639282000907	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
639282000908	signal recognition particle protein; Provisional; Region: PRK10867
639282000909	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
639282000910	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
639282000911	P loop; other site
639282000912	GTP binding site [chemical binding]; other site
639282000913	Signal peptide binding domain; Region: SRP_SPB; pfam02978
639282000914	AAA domain; Region: AAA_30; pfam13604
639282000915	PIF1-like helicase; Region: PIF1; pfam05970
639282000916	Family description; Region: UvrD_C_2; pfam13538
639282000917	WYL domain; Region: WYL; pfam13280
639282000918	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
639282000919	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
639282000920	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
639282000921	active site
639282000922	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
639282000923	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
639282000924	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
639282000925	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
639282000926	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
639282000927	DNA binding residues [nucleotide binding]
639282000928	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
639282000929	protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944
639282000930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282000931	S-adenosylmethionine binding site [chemical binding]; other site
639282000932	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
639282000933	feedback inhibition sensing region; other site
639282000934	homohexameric interface [polypeptide binding]; other site
639282000935	nucleotide binding site [chemical binding]; other site
639282000936	N-acetyl-L-glutamate binding site [chemical binding]; other site
639282000937	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
639282000938	Mechanosensitive ion channel; Region: MS_channel; pfam00924
639282000939	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
639282000940	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
639282000941	ligand binding site [chemical binding]; other site
639282000942	flexible hinge region; other site
639282000943	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
639282000944	putative FMN binding site [chemical binding]; other site
639282000945	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
639282000946	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
639282000947	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
639282000948	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
639282000949	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
639282000950	GTP1/OBG; Region: GTP1_OBG; pfam01018
639282000951	Obg GTPase; Region: Obg; cd01898
639282000952	G1 box; other site
639282000953	GTP/Mg2+ binding site [chemical binding]; other site
639282000954	Switch I region; other site
639282000955	G2 box; other site
639282000956	G3 box; other site
639282000957	Switch II region; other site
639282000958	G4 box; other site
639282000959	G5 box; other site
639282000960	Protein of unknown function (DUF721); Region: DUF721; pfam05258
639282000961	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
639282000962	active site
639282000963	catalytic residues [active]
639282000964	metal binding site [ion binding]; metal-binding site
639282000965	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
639282000966	active site
639282000967	phosphorylation site [posttranslational modification]
639282000968	intermolecular recognition site; other site
639282000969	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
639282000970	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
639282000971	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
639282000972	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
639282000973	G1 box; other site
639282000974	putative GEF interaction site [polypeptide binding]; other site
639282000975	GTP/Mg2+ binding site [chemical binding]; other site
639282000976	Switch I region; other site
639282000977	G2 box; other site
639282000978	G3 box; other site
639282000979	Switch II region; other site
639282000980	G4 box; other site
639282000981	G5 box; other site
639282000982	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
639282000983	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
639282000984	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
639282000985	selenocysteine synthase; Provisional; Region: PRK04311
639282000986	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
639282000987	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
639282000988	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
639282000989	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
639282000990	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282000991	binding surface
639282000992	TPR motif; other site
639282000993	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
639282000994	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
639282000995	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282000996	active site
639282000997	phosphorylation site [posttranslational modification]
639282000998	intermolecular recognition site; other site
639282000999	dimerization interface [polypeptide binding]; other site
639282001000	integrase; Provisional; Region: PRK09692
639282001001	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
639282001002	active site
639282001003	Int/Topo IB signature motif; other site
639282001004	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
639282001005	Transposase domain (DUF772); Region: DUF772; pfam05598
639282001006	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
639282001007	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
639282001008	transposase; Provisional; Region: PRK06526
639282001009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282001010	Walker A motif; other site
639282001011	ATP binding site [chemical binding]; other site
639282001012	Walker B motif; other site
639282001013	Transposase, Mutator family; Region: Transposase_mut; pfam00872
639282001014	MULE transposase domain; Region: MULE; pfam10551
639282001015	Pseudogene. Similar to type I restriction-modification system, M subunit. This CDS appears to have a frameshift mutation
639282001016	Probable gene remnant. Similar to the N-terminal region of Nitratiruptor sp. (strain SB155-2) type I restriction-modification system, M subunit (510 aa) NIS_1707.
639282001017	Probable gene remnant. Similar to the C-terminal region of Nitratiruptor sp. (strain SB155-2) type I restriction-modification system, M subunit (510 aa) NIS_1707.
639282001018	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
639282001019	Fic/DOC family; Region: Fic; cl00960
639282001020	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
639282001021	Divergent AAA domain; Region: AAA_4; pfam04326
639282001022	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
639282001023	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
639282001024	ORF6N domain; Region: ORF6N; pfam10543
639282001025	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
639282001026	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
639282001027	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
639282001028	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
639282001029	Pseudogene. Similar to type I restriction-modification system, R subunit. This CDS appears to have a frameshift mutation
639282001030	Probable gene remnant. Similar to the N-terminal region of Nitratiruptor sp. (strain SB155-2) type I restriction-modification system, R subunit 1058 aa) NIS_1703.
639282001031	Probable gene remnant. Similar to the C-terminal region of Nitratiruptor sp. (strain SB155-2) type I restriction-modification system, R subunit (1058 aa) NIS_1703.
639282001032	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
639282001033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282001034	active site
639282001035	phosphorylation site [posttranslational modification]
639282001036	intermolecular recognition site; other site
639282001037	dimerization interface [polypeptide binding]; other site
639282001038	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
639282001039	DNA binding site [nucleotide binding]
639282001040	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282001041	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282001042	dimer interface [polypeptide binding]; other site
639282001043	phosphorylation site [posttranslational modification]
639282001044	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282001045	ATP binding site [chemical binding]; other site
639282001046	Mg2+ binding site [ion binding]; other site
639282001047	G-X-G motif; other site
639282001048	Uncharacterized conserved protein [Function unknown]; Region: COG1262
639282001049	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
639282001050	DsrE/DsrF-like family; Region: DrsE; cl00672
639282001051	Heavy-metal-associated domain; Region: HMA; pfam00403
639282001052	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
639282001053	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
639282001054	metal-binding site [ion binding]
639282001055	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
639282001056	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
639282001057	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
639282001058	metal-binding site [ion binding]
639282001059	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
639282001060	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
639282001061	metal-binding site [ion binding]
639282001062	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
639282001063	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
639282001064	motif II; other site
639282001065	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
639282001066	metal-binding site [ion binding]
639282001067	Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159
639282001068	putative homodimer interface [polypeptide binding]; other site
639282001069	putative homotetramer interface [polypeptide binding]; other site
639282001070	putative allosteric switch controlling residues; other site
639282001071	putative metal binding site [ion binding]; other site
639282001072	putative homodimer-homodimer interface [polypeptide binding]; other site
639282001073	Short C-terminal domain; Region: SHOCT; pfam09851
639282001074	multicopper oxidase; Provisional; Region: PRK10965
639282001075	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
639282001076	Multicopper oxidase; Region: Cu-oxidase; pfam00394
639282001077	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
639282001078	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
639282001079	Domain of unknown function DUF302; Region: DUF302; cl01364
639282001080	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
639282001081	Short C-terminal domain; Region: SHOCT; pfam09851
639282001082	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
639282001083	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
639282001084	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
639282001085	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
639282001086	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
639282001087	CoA-binding site [chemical binding]; other site
639282001088	ATP-binding [chemical binding]; other site
639282001089	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
639282001090	PAS domain; Region: PAS_9; pfam13426
639282001091	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
639282001092	putative active site [active]
639282001093	heme pocket [chemical binding]; other site
639282001094	PAS domain S-box; Region: sensory_box; TIGR00229
639282001095	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
639282001096	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282001097	dimer interface [polypeptide binding]; other site
639282001098	phosphorylation site [posttranslational modification]
639282001099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282001100	ATP binding site [chemical binding]; other site
639282001101	Mg2+ binding site [ion binding]; other site
639282001102	G-X-G motif; other site
639282001103	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
639282001104	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
639282001105	substrate binding site [chemical binding]; other site
639282001106	active site
639282001107	ferrochelatase; Reviewed; Region: hemH; PRK00035
639282001108	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
639282001109	active site
639282001110	C-terminal domain interface [polypeptide binding]; other site
639282001111	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
639282001112	active site
639282001113	N-terminal domain interface [polypeptide binding]; other site
639282001114	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
639282001115	UbiA prenyltransferase family; Region: UbiA; pfam01040
639282001116	aromatic acid decarboxylase; Validated; Region: PRK05920
639282001117	Flavoprotein; Region: Flavoprotein; pfam02441
639282001118	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
639282001119	HDOD domain; Region: HDOD; pfam08668
639282001120	HD domain; Region: HD; pfam01966
639282001121	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
639282001122	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
639282001123	substrate binding site [chemical binding]; other site
639282001124	oxyanion hole (OAH) forming residues; other site
639282001125	trimer interface [polypeptide binding]; other site
639282001126	enoyl-CoA hydratase; Provisional; Region: PRK06142
639282001127	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
639282001128	substrate binding site [chemical binding]; other site
639282001129	oxyanion hole (OAH) forming residues; other site
639282001130	trimer interface [polypeptide binding]; other site
639282001131	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
639282001132	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
639282001133	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
639282001134	Walker A/P-loop; other site
639282001135	ATP binding site [chemical binding]; other site
639282001136	Q-loop/lid; other site
639282001137	ABC transporter signature motif; other site
639282001138	Walker B; other site
639282001139	D-loop; other site
639282001140	H-loop/switch region; other site
639282001141	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
639282001142	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
639282001143	putative ADP-binding pocket [chemical binding]; other site
639282001144	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
639282001145	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
639282001146	putative ADP-binding pocket [chemical binding]; other site
639282001147	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
639282001148	putative metal binding site; other site
639282001149	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
639282001150	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
639282001151	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
639282001152	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
639282001153	putative active site [active]
639282001154	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
639282001155	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
639282001156	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
639282001157	putative active site [active]
639282001158	putative metal binding site [ion binding]; other site
639282001159	O-Antigen ligase; Region: Wzy_C; pfam04932
639282001160	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
639282001161	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
639282001162	putative ADP-binding pocket [chemical binding]; other site
639282001163	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
639282001164	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
639282001165	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
639282001166	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
639282001167	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
639282001168	putative ADP-binding pocket [chemical binding]; other site
639282001169	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
639282001170	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
639282001171	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
639282001172	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
639282001173	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
639282001174	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
639282001175	Uncharacterized conserved protein [Function unknown]; Region: COG1633
639282001176	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
639282001177	diiron binding motif [ion binding]; other site
639282001178	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
639282001179	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
639282001180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282001181	homodimer interface [polypeptide binding]; other site
639282001182	catalytic residue [active]
639282001183	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
639282001184	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
639282001185	CPxP  motif; other site
639282001186	DsrE/DsrF-like family; Region: DrsE; pfam02635
639282001187	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
639282001188	dimerization interface [polypeptide binding]; other site
639282001189	putative ATP binding site [chemical binding]; other site
639282001190	Ribonuclease P; Region: Ribonuclease_P; pfam00825
639282001191	Haemolytic domain; Region: Haemolytic; pfam01809
639282001192	membrane protein insertase; Provisional; Region: PRK01318
639282001193	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
639282001194	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
639282001195	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
639282001196	G-X-X-G motif; other site
639282001197	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
639282001198	RxxxH motif; other site
639282001199	YHS domain; Region: YHS; pfam04945
639282001200	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
639282001201	active site
639282001202	intersubunit interactions; other site
639282001203	catalytic residue [active]
639282001204	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
639282001205	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
639282001206	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
639282001207	metal binding triad [ion binding]; metal-binding site
639282001208	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
639282001209	Helix-hairpin-helix motif; Region: HHH; pfam00633
639282001210	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
639282001211	GIY-YIG motif/motif A; other site
639282001212	putative active site [active]
639282001213	putative metal binding site [ion binding]; other site
639282001214	Probable gene remnant. Similar to the central region of Chlorobium phaeobacteroides BS1 small subunit ribosomal protein S23e (143 aa). Cphamn1DRAFT_2274.
639282001215	Pseudogene. Similar to conserved hypothetical protein. This CDS appears to have a frameshift mutation
639282001216	Probable gene remnant. Similar to the N-terminal region of Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) conserved hypothetical protein (186 aa). BVU_1112.
639282001217	Probable gene remnant. Similar to the C-terminal region of Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) conserved hypothetical protein (186 aa). BVU_1112
639282001218	Probable gene remnant. Similar to the C-terminal region of Chlorobium phaeobacteroides BS1 small subunit ribosomal protein S23e (143 aa). Cphamn1DRAFT_2274
639282001219	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
639282001220	Pseudogene. Similar to glucosamine--fructose-6-phosphate aminotransferase, isomerizing. This CDS appears to have a frameshift mutation
639282001221	Probable gene remnant. Similar to the N-terminal region of Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1) glutamine--fructose-6-phosphate transaminase (609 aa). Pcar_2933
639282001222	Probable gene remnant. Similar to the C-terminal region of Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1) glutamine--fructose-6-phosphate transaminase (609 aa). Pcar_2933
639282001223	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
639282001224	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
639282001225	NAD(P) binding site [chemical binding]; other site
639282001226	homodimer interface [polypeptide binding]; other site
639282001227	substrate binding site [chemical binding]; other site
639282001228	active site
639282001229	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
639282001230	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
639282001231	inhibitor-cofactor binding pocket; inhibition site
639282001232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282001233	catalytic residue [active]
639282001234	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
639282001235	active site
639282001236	cosubstrate binding site; other site
639282001237	substrate binding site [chemical binding]; other site
639282001238	catalytic site [active]
639282001239	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
639282001240	NeuB family; Region: NeuB; pfam03102
639282001241	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
639282001242	NeuB binding interface [polypeptide binding]; other site
639282001243	putative substrate binding site [chemical binding]; other site
639282001244	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
639282001245	classical (c) SDRs; Region: SDR_c; cd05233
639282001246	NAD(P) binding site [chemical binding]; other site
639282001247	active site
639282001248	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
639282001249	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
639282001250	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
639282001251	acyl-activating enzyme (AAE) consensus motif; other site
639282001252	active site
639282001253	AMP binding site [chemical binding]; other site
639282001254	CoA binding site [chemical binding]; other site
639282001255	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
639282001256	Coenzyme A binding pocket [chemical binding]; other site
639282001257	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
639282001258	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
639282001259	active site
639282001260	homodimer interface [polypeptide binding]; other site
639282001261	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
639282001262	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
639282001263	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
639282001264	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
639282001265	Substrate binding site; other site
639282001266	metal-binding site
639282001267	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
639282001268	ligand binding site; other site
639282001269	tetramer interface; other site
639282001270	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
639282001271	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
639282001272	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
639282001273	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
639282001274	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
639282001275	active site
639282001276	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
639282001277	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
639282001278	Mg++ binding site [ion binding]; other site
639282001279	putative catalytic motif [active]
639282001280	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
639282001281	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
639282001282	active site
639282001283	NTP binding site [chemical binding]; other site
639282001284	metal binding triad [ion binding]; metal-binding site
639282001285	antibiotic binding site [chemical binding]; other site
639282001286	Protein of unknown function DUF86; Region: DUF86; cl01031
639282001287	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
639282001288	AAA domain; Region: AAA_14; pfam13173
639282001289	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
639282001290	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282001291	Walker A motif; other site
639282001292	ATP binding site [chemical binding]; other site
639282001293	Walker B motif; other site
639282001294	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
639282001295	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
639282001296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282001297	Walker A motif; other site
639282001298	ATP binding site [chemical binding]; other site
639282001299	Walker B motif; other site
639282001300	arginine finger; other site
639282001301	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
639282001302	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
639282001303	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
639282001304	putative active site [active]
639282001305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
639282001306	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
639282001307	PBP superfamily domain; Region: PBP_like_2; cl17296
639282001308	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
639282001309	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282001310	dimer interface [polypeptide binding]; other site
639282001311	conserved gate region; other site
639282001312	putative PBP binding loops; other site
639282001313	ABC-ATPase subunit interface; other site
639282001314	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
639282001315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282001316	dimer interface [polypeptide binding]; other site
639282001317	conserved gate region; other site
639282001318	ABC-ATPase subunit interface; other site
639282001319	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
639282001320	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
639282001321	Walker A/P-loop; other site
639282001322	ATP binding site [chemical binding]; other site
639282001323	Q-loop/lid; other site
639282001324	ABC transporter signature motif; other site
639282001325	Walker B; other site
639282001326	D-loop; other site
639282001327	H-loop/switch region; other site
639282001328	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
639282001329	PhoU domain; Region: PhoU; pfam01895
639282001330	PhoU domain; Region: PhoU; pfam01895
639282001331	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
639282001332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282001333	active site
639282001334	phosphorylation site [posttranslational modification]
639282001335	intermolecular recognition site; other site
639282001336	dimerization interface [polypeptide binding]; other site
639282001337	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
639282001338	DNA binding site [nucleotide binding]
639282001339	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282001340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282001341	dimer interface [polypeptide binding]; other site
639282001342	phosphorylation site [posttranslational modification]
639282001343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282001344	ATP binding site [chemical binding]; other site
639282001345	Mg2+ binding site [ion binding]; other site
639282001346	G-X-G motif; other site
639282001347	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
639282001348	ABC1 family; Region: ABC1; pfam03109
639282001349	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
639282001350	active site
639282001351	ATP binding site [chemical binding]; other site
639282001352	conserved hypothetical protein; Region: MG423; TIGR00649
639282001353	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
639282001354	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
639282001355	Bacitracin resistance protein BacA; Region: BacA; pfam02673
639282001356	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
639282001357	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
639282001358	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
639282001359	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
639282001360	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
639282001361	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
639282001362	phosphate binding site [ion binding]; other site
639282001363	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
639282001364	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
639282001365	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
639282001366	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
639282001367	FHIPEP family; Region: FHIPEP; pfam00771
639282001368	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
639282001369	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
639282001370	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
639282001371	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
639282001372	P-loop; other site
639282001373	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
639282001374	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
639282001375	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
639282001376	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
639282001377	DNA binding residues [nucleotide binding]
639282001378	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
639282001379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282001380	active site
639282001381	phosphorylation site [posttranslational modification]
639282001382	intermolecular recognition site; other site
639282001383	dimerization interface [polypeptide binding]; other site
639282001384	CheB methylesterase; Region: CheB_methylest; pfam01339
639282001385	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
639282001386	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
639282001387	flagellar motor switch protein FliY; Validated; Region: PRK08432
639282001388	flagellar motor switch protein FliN; Region: fliN; TIGR02480
639282001389	Response regulator receiver domain; Region: Response_reg; pfam00072
639282001390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282001391	active site
639282001392	phosphorylation site [posttranslational modification]
639282001393	intermolecular recognition site; other site
639282001394	dimerization interface [polypeptide binding]; other site
639282001395	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
639282001396	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
639282001397	putative binding surface; other site
639282001398	active site
639282001399	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
639282001400	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
639282001401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282001402	ATP binding site [chemical binding]; other site
639282001403	Mg2+ binding site [ion binding]; other site
639282001404	G-X-G motif; other site
639282001405	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
639282001406	Response regulator receiver domain; Region: Response_reg; pfam00072
639282001407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282001408	active site
639282001409	phosphorylation site [posttranslational modification]
639282001410	intermolecular recognition site; other site
639282001411	dimerization interface [polypeptide binding]; other site
639282001412	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
639282001413	ligand binding site [chemical binding]; other site
639282001414	PAS domain; Region: PAS_9; pfam13426
639282001415	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
639282001416	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
639282001417	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
639282001418	anti sigma factor interaction site; other site
639282001419	regulatory phosphorylation site [posttranslational modification]; other site
639282001420	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
639282001421	anti sigma factor interaction site; other site
639282001422	regulatory phosphorylation site [posttranslational modification]; other site
639282001423	HEAT repeats; Region: HEAT_2; pfam13646
639282001424	HEAT repeats; Region: HEAT_2; pfam13646
639282001425	HEAT repeats; Region: HEAT_2; pfam13646
639282001426	HEAT repeats; Region: HEAT_2; pfam13646
639282001427	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
639282001428	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
639282001429	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282001430	S-adenosylmethionine binding site [chemical binding]; other site
639282001431	PilZ domain; Region: PilZ; pfam07238
639282001432	FeoA domain; Region: FeoA; pfam04023
639282001433	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
639282001434	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
639282001435	G1 box; other site
639282001436	GTP/Mg2+ binding site [chemical binding]; other site
639282001437	Switch I region; other site
639282001438	G2 box; other site
639282001439	G3 box; other site
639282001440	Switch II region; other site
639282001441	G4 box; other site
639282001442	G5 box; other site
639282001443	Nucleoside recognition; Region: Gate; pfam07670
639282001444	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
639282001445	Nucleoside recognition; Region: Gate; pfam07670
639282001446	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
639282001447	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
639282001448	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
639282001449	Glutamine amidotransferase class-I; Region: GATase; pfam00117
639282001450	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
639282001451	glutamine binding [chemical binding]; other site
639282001452	catalytic triad [active]
639282001453	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
639282001454	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
639282001455	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
639282001456	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
639282001457	active site
639282001458	ribulose/triose binding site [chemical binding]; other site
639282001459	phosphate binding site [ion binding]; other site
639282001460	substrate (anthranilate) binding pocket [chemical binding]; other site
639282001461	product (indole) binding pocket [chemical binding]; other site
639282001462	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
639282001463	active site
639282001464	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
639282001465	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
639282001466	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282001467	catalytic residue [active]
639282001468	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
639282001469	substrate binding site [chemical binding]; other site
639282001470	active site
639282001471	catalytic residues [active]
639282001472	heterodimer interface [polypeptide binding]; other site
639282001473	ribonuclease PH; Reviewed; Region: rph; PRK00173
639282001474	Ribonuclease PH; Region: RNase_PH_bact; cd11362
639282001475	hexamer interface [polypeptide binding]; other site
639282001476	active site
639282001477	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
639282001478	active site
639282001479	dimerization interface [polypeptide binding]; other site
639282001480	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
639282001481	shikimate kinase; Reviewed; Region: aroK; PRK00131
639282001482	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
639282001483	ADP binding site [chemical binding]; other site
639282001484	magnesium binding site [ion binding]; other site
639282001485	putative shikimate binding site; other site
639282001486	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
639282001487	active site
639282001488	dimer interface [polypeptide binding]; other site
639282001489	metal binding site [ion binding]; metal-binding site
639282001490	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282001491	TPR motif; other site
639282001492	binding surface
639282001493	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
639282001494	Dehydroquinase class II; Region: DHquinase_II; pfam01220
639282001495	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
639282001496	trimer interface [polypeptide binding]; other site
639282001497	active site
639282001498	dimer interface [polypeptide binding]; other site
639282001499	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
639282001500	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
639282001501	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
639282001502	active site
639282001503	elongation factor P; Validated; Region: PRK00529
639282001504	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
639282001505	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
639282001506	RNA binding site [nucleotide binding]; other site
639282001507	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
639282001508	RNA binding site [nucleotide binding]; other site
639282001509	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
639282001510	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
639282001511	carboxyltransferase (CT) interaction site; other site
639282001512	biotinylation site [posttranslational modification]; other site
639282001513	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
639282001514	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
639282001515	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
639282001516	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
639282001517	TPR repeat; Region: TPR_11; pfam13414
639282001518	Tetratricopeptide repeat; Region: TPR_12; pfam13424
639282001519	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282001520	binding surface
639282001521	TPR motif; other site
639282001522	TPR repeat; Region: TPR_11; pfam13414
639282001523	TPR repeat; Region: TPR_11; pfam13414
639282001524	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282001525	binding surface
639282001526	TPR motif; other site
639282001527	TPR repeat; Region: TPR_11; pfam13414
639282001528	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282001529	binding surface
639282001530	TPR motif; other site
639282001531	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
639282001532	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
639282001533	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
639282001534	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
639282001535	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
639282001536	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
639282001537	active site
639282001538	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
639282001539	putative active site [active]
639282001540	catalytic residue [active]
639282001541	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
639282001542	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
639282001543	GTP-binding protein YchF; Reviewed; Region: PRK09601
639282001544	YchF GTPase; Region: YchF; cd01900
639282001545	G1 box; other site
639282001546	GTP/Mg2+ binding site [chemical binding]; other site
639282001547	Switch I region; other site
639282001548	G2 box; other site
639282001549	Switch II region; other site
639282001550	G3 box; other site
639282001551	G4 box; other site
639282001552	G5 box; other site
639282001553	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
639282001554	Bacterial SH3 domain homologues; Region: SH3b; smart00287
639282001555	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
639282001556	trimer interface [polypeptide binding]; other site
639282001557	dimer interface [polypeptide binding]; other site
639282001558	putative active site [active]
639282001559	Predicted amidohydrolase [General function prediction only]; Region: COG0388
639282001560	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586
639282001561	putative active site [active]
639282001562	catalytic triad [active]
639282001563	putative dimer interface [polypeptide binding]; other site
639282001564	NAD synthetase; Provisional; Region: PRK13980
639282001565	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
639282001566	homodimer interface [polypeptide binding]; other site
639282001567	NAD binding pocket [chemical binding]; other site
639282001568	ATP binding pocket [chemical binding]; other site
639282001569	Mg binding site [ion binding]; other site
639282001570	active-site loop [active]
639282001571	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
639282001572	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
639282001573	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
639282001574	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
639282001575	active site
639282001576	GMP synthase; Reviewed; Region: guaA; PRK00074
639282001577	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
639282001578	AMP/PPi binding site [chemical binding]; other site
639282001579	candidate oxyanion hole; other site
639282001580	catalytic triad [active]
639282001581	potential glutamine specificity residues [chemical binding]; other site
639282001582	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
639282001583	ATP Binding subdomain [chemical binding]; other site
639282001584	Ligand Binding sites [chemical binding]; other site
639282001585	Dimerization subdomain; other site
639282001586	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
639282001587	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
639282001588	FtsX-like permease family; Region: FtsX; pfam02687
639282001589	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
639282001590	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
639282001591	Walker A/P-loop; other site
639282001592	ATP binding site [chemical binding]; other site
639282001593	Q-loop/lid; other site
639282001594	ABC transporter signature motif; other site
639282001595	Walker B; other site
639282001596	D-loop; other site
639282001597	H-loop/switch region; other site
639282001598	UPF0126 domain; Region: UPF0126; pfam03458
639282001599	Predicted membrane protein [Function unknown]; Region: COG2860
639282001600	UPF0126 domain; Region: UPF0126; pfam03458
639282001601	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
639282001602	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
639282001603	FAD binding domain; Region: FAD_binding_4; pfam01565
639282001604	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
639282001605	LexA repressor; Validated; Region: PRK00215
639282001606	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
639282001607	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
639282001608	Catalytic site [active]
639282001609	DNA polymerase IV; Reviewed; Region: PRK03103
639282001610	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
639282001611	active site
639282001612	DNA binding site [nucleotide binding]
639282001613	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
639282001614	Cell division protein ZapA; Region: ZapA; pfam05164
639282001615	recombination factor protein RarA; Reviewed; Region: PRK13342
639282001616	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282001617	Walker A motif; other site
639282001618	ATP binding site [chemical binding]; other site
639282001619	Walker B motif; other site
639282001620	arginine finger; other site
639282001621	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
639282001622	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
639282001623	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
639282001624	phosphodiesterase; Provisional; Region: PRK12704
639282001625	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282001626	Zn2+ binding site [ion binding]; other site
639282001627	Mg2+ binding site [ion binding]; other site
639282001628	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
639282001629	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
639282001630	putative active site [active]
639282001631	metal binding site [ion binding]; metal-binding site
639282001632	homodimer binding site [polypeptide binding]; other site
639282001633	Quinolinate synthetase A protein; Region: NadA; pfam02445
639282001634	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
639282001635	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
639282001636	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
639282001637	dimer interface [polypeptide binding]; other site
639282001638	active site
639282001639	glycine-pyridoxal phosphate binding site [chemical binding]; other site
639282001640	folate binding site [chemical binding]; other site
639282001641	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
639282001642	catalytic motif [active]
639282001643	Zn binding site [ion binding]; other site
639282001644	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
639282001645	SLBB domain; Region: SLBB; pfam10531
639282001646	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
639282001647	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
639282001648	FMN-binding domain; Region: FMN_bind; cl01081
639282001649	electron transport complex RsxE subunit; Provisional; Region: PRK12405
639282001650	Predicted NADH:ubiquinone oxidoreductase, subunit RnfA [Energy production and conversion]; Region: RnfA; COG4657
639282001651	ferredoxin; Validated; Region: PRK07118
639282001652	Putative Fe-S cluster; Region: FeS; cl17515
639282001653	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
639282001654	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
639282001655	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
639282001656	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
639282001657	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
639282001658	active site
639282001659	Zn binding site [ion binding]; other site
639282001660	FOG: CBS domain [General function prediction only]; Region: COG0517
639282001661	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
639282001662	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
639282001663	NRDE protein; Region: NRDE; cl01315
639282001664	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
639282001665	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
639282001666	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
639282001667	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
639282001668	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
639282001669	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282001670	Zn2+ binding site [ion binding]; other site
639282001671	Mg2+ binding site [ion binding]; other site
639282001672	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
639282001673	Moco binding site; other site
639282001674	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
639282001675	metal coordination site [ion binding]; other site
639282001676	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
639282001677	Predicted methyltransferases [General function prediction only]; Region: COG0313
639282001678	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
639282001679	putative SAM binding site [chemical binding]; other site
639282001680	putative homodimer interface [polypeptide binding]; other site
639282001681	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
639282001682	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
639282001683	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
639282001684	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
639282001685	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
639282001686	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
639282001687	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
639282001688	dimerization interface [polypeptide binding]; other site
639282001689	active site
639282001690	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
639282001691	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
639282001692	HIGH motif; other site
639282001693	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
639282001694	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
639282001695	active site
639282001696	KMSKS motif; other site
639282001697	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
639282001698	tRNA binding surface [nucleotide binding]; other site
639282001699	anticodon binding site; other site
639282001700	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
639282001701	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
639282001702	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
639282001703	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
639282001704	putative substrate binding site [chemical binding]; other site
639282001705	putative ATP binding site [chemical binding]; other site
639282001706	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
639282001707	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
639282001708	putative ribose interaction site [chemical binding]; other site
639282001709	putative ADP binding site [chemical binding]; other site
639282001710	Uncharacterized conserved protein [Function unknown]; Region: COG2835
639282001711	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
639282001712	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
639282001713	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282001714	FeS/SAM binding site; other site
639282001715	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
639282001716	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
639282001717	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
639282001718	putative active site [active]
639282001719	catalytic site [active]
639282001720	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
639282001721	putative active site [active]
639282001722	catalytic site [active]
639282001723	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
639282001724	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
639282001725	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
639282001726	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
639282001727	Ligand Binding Site [chemical binding]; other site
639282001728	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
639282001729	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
639282001730	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
639282001731	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
639282001732	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
639282001733	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
639282001734	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
639282001735	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
639282001736	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
639282001737	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
639282001738	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
639282001739	FliG C-terminal domain; Region: FliG_C; pfam01706
639282001740	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
639282001741	Flagellar assembly protein FliH; Region: FliH; pfam02108
639282001742	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
639282001743	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
639282001744	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
639282001745	Walker A motif/ATP binding site; other site
639282001746	Walker B motif; other site
639282001747	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
639282001748	Uncharacterized conserved protein [Function unknown]; Region: COG3334
639282001749	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282001750	S-adenosylmethionine binding site [chemical binding]; other site
639282001751	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
639282001752	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
639282001753	Peptidase family U32; Region: Peptidase_U32; pfam01136
639282001754	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
639282001755	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
639282001756	nucleotide binding pocket [chemical binding]; other site
639282001757	K-X-D-G motif; other site
639282001758	catalytic site [active]
639282001759	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
639282001760	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
639282001761	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
639282001762	Dimer interface [polypeptide binding]; other site
639282001763	BRCT sequence motif; other site
639282001764	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
639282001765	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
639282001766	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
639282001767	N-terminal plug; other site
639282001768	ligand-binding site [chemical binding]; other site
639282001769	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
639282001770	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
639282001771	intersubunit interface [polypeptide binding]; other site
639282001772	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
639282001773	homodimer interface [polypeptide binding]; other site
639282001774	Walker A motif; other site
639282001775	ATP binding site [chemical binding]; other site
639282001776	hydroxycobalamin binding site [chemical binding]; other site
639282001777	Walker B motif; other site
639282001778	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
639282001779	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
639282001780	ABC-ATPase subunit  interface; other site
639282001781	dimer interface [polypeptide binding]; other site
639282001782	putative PBP binding regions; other site
639282001783	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
639282001784	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
639282001785	Walker A/P-loop; other site
639282001786	ATP binding site [chemical binding]; other site
639282001787	Q-loop/lid; other site
639282001788	ABC transporter signature motif; other site
639282001789	Walker B; other site
639282001790	D-loop; other site
639282001791	H-loop/switch region; other site
639282001792	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
639282001793	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
639282001794	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
639282001795	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
639282001796	CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592
639282001797	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
639282001798	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
639282001799	active site
639282001800	NTP binding site [chemical binding]; other site
639282001801	metal binding triad [ion binding]; metal-binding site
639282001802	antibiotic binding site [chemical binding]; other site
639282001803	Family of unknown function (DUF694); Region: DUF694; pfam05107
639282001804	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
639282001805	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
639282001806	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
639282001807	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
639282001808	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
639282001809	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
639282001810	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
639282001811	active site
639282001812	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
639282001813	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
639282001814	hypothetical protein; Reviewed; Region: PRK00024
639282001815	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
639282001816	MPN+ (JAMM) motif; other site
639282001817	Zinc-binding site [ion binding]; other site
639282001818	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
639282001819	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
639282001820	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
639282001821	putative NAD(P) binding site [chemical binding]; other site
639282001822	active site
639282001823	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
639282001824	active site
639282001825	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
639282001826	active site
639282001827	dimer interface [polypeptide binding]; other site
639282001828	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
639282001829	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
639282001830	dimer interface [polypeptide binding]; other site
639282001831	PYR/PP interface [polypeptide binding]; other site
639282001832	TPP binding site [chemical binding]; other site
639282001833	substrate binding site [chemical binding]; other site
639282001834	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
639282001835	Domain of unknown function; Region: EKR; pfam10371
639282001836	4Fe-4S binding domain; Region: Fer4_6; pfam12837
639282001837	4Fe-4S binding domain; Region: Fer4; pfam00037
639282001838	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
639282001839	TPP-binding site [chemical binding]; other site
639282001840	dimer interface [polypeptide binding]; other site
639282001841	AMP-binding domain protein; Validated; Region: PRK08315
639282001842	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
639282001843	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
639282001844	acyl-activating enzyme (AAE) consensus motif; other site
639282001845	acyl-activating enzyme (AAE) consensus motif; other site
639282001846	putative AMP binding site [chemical binding]; other site
639282001847	putative active site [active]
639282001848	putative CoA binding site [chemical binding]; other site
639282001849	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
639282001850	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
639282001851	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
639282001852	TrkA-N domain; Region: TrkA_N; pfam02254
639282001853	TrkA-C domain; Region: TrkA_C; pfam02080
639282001854	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
639282001855	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
639282001856	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
639282001857	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
639282001858	Rubredoxin; Region: Rubredoxin; pfam00301
639282001859	iron binding site [ion binding]; other site
639282001860	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
639282001861	DHH family; Region: DHH; pfam01368
639282001862	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
639282001863	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
639282001864	NAD(P) binding site [chemical binding]; other site
639282001865	active site
639282001866	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
639282001867	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
639282001868	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
639282001869	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
639282001870	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
639282001871	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
639282001872	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
639282001873	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
639282001874	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
639282001875	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
639282001876	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
639282001877	substrate binding pocket [chemical binding]; other site
639282001878	membrane-bound complex binding site; other site
639282001879	hinge residues; other site
639282001880	PAS domain; Region: PAS_9; pfam13426
639282001881	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282001882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
639282001883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282001884	ATP binding site [chemical binding]; other site
639282001885	G-X-G motif; other site
639282001886	cell division protein MraZ; Reviewed; Region: PRK00326
639282001887	MraZ protein; Region: MraZ; pfam02381
639282001888	MraZ protein; Region: MraZ; pfam02381
639282001889	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
639282001890	MraW methylase family; Region: Methyltransf_5; cl17771
639282001891	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
639282001892	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
639282001893	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
639282001894	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
639282001895	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
639282001896	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
639282001897	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
639282001898	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
639282001899	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
639282001900	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
639282001901	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
639282001902	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
639282001903	Mg++ binding site [ion binding]; other site
639282001904	putative catalytic motif [active]
639282001905	putative substrate binding site [chemical binding]; other site
639282001906	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
639282001907	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
639282001908	cell division protein FtsW; Region: ftsW; TIGR02614
639282001909	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
639282001910	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
639282001911	active site
639282001912	homodimer interface [polypeptide binding]; other site
639282001913	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
639282001914	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
639282001915	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
639282001916	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
639282001917	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
639282001918	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
639282001919	ATP-grasp domain; Region: ATP-grasp_4; cl17255
639282001920	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
639282001921	cell division protein FtsA; Region: ftsA; TIGR01174
639282001922	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
639282001923	nucleotide binding site [chemical binding]; other site
639282001924	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
639282001925	Cell division protein FtsA; Region: FtsA; pfam14450
639282001926	cell division protein FtsZ; Validated; Region: PRK09330
639282001927	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
639282001928	nucleotide binding site [chemical binding]; other site
639282001929	SulA interaction site; other site
639282001930	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
639282001931	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
639282001932	ThiS family; Region: ThiS; pfam02597
639282001933	charged pocket; other site
639282001934	hydrophobic patch; other site
639282001935	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
639282001936	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
639282001937	Ligand Binding Site [chemical binding]; other site
639282001938	TIGR00269 family protein; Region: TIGR00269
639282001939	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
639282001940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282001941	S-adenosylmethionine binding site [chemical binding]; other site
639282001942	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
639282001943	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
639282001944	Ligand binding site; other site
639282001945	Putative Catalytic site; other site
639282001946	DXD motif; other site
639282001947	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
639282001948	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
639282001949	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
639282001950	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
639282001951	Moco binding site; other site
639282001952	metal coordination site [ion binding]; other site
639282001953	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
639282001954	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
639282001955	Tetramer interface [polypeptide binding]; other site
639282001956	active site
639282001957	FMN-binding site [chemical binding]; other site
639282001958	PAS domain; Region: PAS_9; pfam13426
639282001959	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282001960	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282001961	metal binding site [ion binding]; metal-binding site
639282001962	active site
639282001963	I-site; other site
639282001964	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
639282001965	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
639282001966	Outer membrane efflux protein; Region: OEP; pfam02321
639282001967	Outer membrane efflux protein; Region: OEP; pfam02321
639282001968	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
639282001969	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
639282001970	HlyD family secretion protein; Region: HlyD_3; pfam13437
639282001971	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
639282001972	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
639282001973	putative substrate translocation pore; other site
639282001974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
639282001975	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
639282001976	EamA-like transporter family; Region: EamA; pfam00892
639282001977	EamA-like transporter family; Region: EamA; pfam00892
639282001978	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
639282001979	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
639282001980	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282001981	homodimer interface [polypeptide binding]; other site
639282001982	catalytic residue [active]
639282001983	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
639282001984	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
639282001985	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
639282001986	active site
639282001987	catalytic site [active]
639282001988	substrate binding site [chemical binding]; other site
639282001989	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
639282001990	Domain of unknown function (DUF814); Region: DUF814; pfam05670
639282001991	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
639282001992	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
639282001993	Walker A motif; other site
639282001994	ATP binding site [chemical binding]; other site
639282001995	Walker B motif; other site
639282001996	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
639282001997	Membrane protein of unknown function; Region: DUF360; pfam04020
639282001998	Domain of unknown function (DUF1820); Region: DUF1820; cl11545
639282001999	Predicted permeases [General function prediction only]; Region: COG0795
639282002000	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
639282002001	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
639282002002	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
639282002003	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
639282002004	Ferredoxin [Energy production and conversion]; Region: COG1146
639282002005	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
639282002006	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
639282002007	dimer interface [polypeptide binding]; other site
639282002008	PYR/PP interface [polypeptide binding]; other site
639282002009	TPP binding site [chemical binding]; other site
639282002010	substrate binding site [chemical binding]; other site
639282002011	RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p), ribosomal RNA-processing protein 7 homolog A (Rrp7A), and similar proteins; Region: RRP7_like; cl15166
639282002012	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
639282002013	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
639282002014	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
639282002015	TPP-binding site [chemical binding]; other site
639282002016	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
639282002017	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
639282002018	Acylphosphatase; Region: Acylphosphatase; pfam00708
639282002019	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
639282002020	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
639282002021	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
639282002022	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
639282002023	RNA binding site [nucleotide binding]; other site
639282002024	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
639282002025	dimer interface [polypeptide binding]; other site
639282002026	motif 1; other site
639282002027	active site
639282002028	motif 2; other site
639282002029	motif 3; other site
639282002030	Cache domain; Region: Cache_1; pfam02743
639282002031	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
639282002032	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282002033	dimerization interface [polypeptide binding]; other site
639282002034	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
639282002035	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282002036	dimer interface [polypeptide binding]; other site
639282002037	putative CheW interface [polypeptide binding]; other site
639282002038	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
639282002039	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
639282002040	acyl-activating enzyme (AAE) consensus motif; other site
639282002041	putative AMP binding site [chemical binding]; other site
639282002042	putative active site [active]
639282002043	putative CoA binding site [chemical binding]; other site
639282002044	Maf-like protein; Region: Maf; pfam02545
639282002045	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
639282002046	active site
639282002047	dimer interface [polypeptide binding]; other site
639282002048	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
639282002049	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
639282002050	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
639282002051	ApbE family; Region: ApbE; pfam02424
639282002052	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
639282002053	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282002054	FeS/SAM binding site; other site
639282002055	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
639282002056	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
639282002057	substrate binding pocket [chemical binding]; other site
639282002058	chain length determination region; other site
639282002059	substrate-Mg2+ binding site; other site
639282002060	catalytic residues [active]
639282002061	aspartate-rich region 1; other site
639282002062	active site lid residues [active]
639282002063	aspartate-rich region 2; other site
639282002064	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
639282002065	homotrimer interaction site [polypeptide binding]; other site
639282002066	putative active site [active]
639282002067	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
639282002068	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
639282002069	FOG: WD40 repeat [General function prediction only]; Region: COG2319
639282002070	LVIVD repeat; Region: LVIVD; pfam08309
639282002071	LVIVD repeat; Region: LVIVD; pfam08309
639282002072	LVIVD repeat; Region: LVIVD; pfam08309
639282002073	LVIVD repeat; Region: LVIVD; pfam08309
639282002074	LVIVD repeat; Region: LVIVD; pfam08309
639282002075	LVIVD repeat; Region: LVIVD; pfam08309
639282002076	LVIVD repeat; Region: LVIVD; pfam08309
639282002077	LVIVD repeat; Region: LVIVD; pfam08309
639282002078	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
639282002079	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
639282002080	dimerization interface [polypeptide binding]; other site
639282002081	ligand binding site [chemical binding]; other site
639282002082	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
639282002083	TM-ABC transporter signature motif; other site
639282002084	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
639282002085	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
639282002086	TM-ABC transporter signature motif; other site
639282002087	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
639282002088	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
639282002089	Walker A/P-loop; other site
639282002090	ATP binding site [chemical binding]; other site
639282002091	Q-loop/lid; other site
639282002092	ABC transporter signature motif; other site
639282002093	Walker B; other site
639282002094	D-loop; other site
639282002095	H-loop/switch region; other site
639282002096	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
639282002097	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
639282002098	Walker A/P-loop; other site
639282002099	ATP binding site [chemical binding]; other site
639282002100	Q-loop/lid; other site
639282002101	ABC transporter signature motif; other site
639282002102	Walker B; other site
639282002103	D-loop; other site
639282002104	H-loop/switch region; other site
639282002105	ribonuclease R; Region: RNase_R; TIGR02063
639282002106	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
639282002107	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
639282002108	RNB domain; Region: RNB; pfam00773
639282002109	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
639282002110	RNA binding site [nucleotide binding]; other site
639282002111	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
639282002112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282002113	active site
639282002114	phosphorylation site [posttranslational modification]
639282002115	intermolecular recognition site; other site
639282002116	dimerization interface [polypeptide binding]; other site
639282002117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282002118	Walker A motif; other site
639282002119	ATP binding site [chemical binding]; other site
639282002120	Walker B motif; other site
639282002121	arginine finger; other site
639282002122	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
639282002123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282002124	dimer interface [polypeptide binding]; other site
639282002125	phosphorylation site [posttranslational modification]
639282002126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282002127	ATP binding site [chemical binding]; other site
639282002128	Mg2+ binding site [ion binding]; other site
639282002129	G-X-G motif; other site
639282002130	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
639282002131	Transglycosylase; Region: Transgly; pfam00912
639282002132	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
639282002133	excinuclease ABC subunit B; Provisional; Region: PRK05298
639282002134	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
639282002135	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
639282002136	ATP-binding site [chemical binding]; other site
639282002137	ATP binding site [chemical binding]; other site
639282002138	putative Mg++ binding site [ion binding]; other site
639282002139	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
639282002140	nucleotide binding region [chemical binding]; other site
639282002141	ATP-binding site [chemical binding]; other site
639282002142	Ultra-violet resistance protein B; Region: UvrB; pfam12344
639282002143	UvrB/uvrC motif; Region: UVR; pfam02151
639282002144	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
639282002145	dimerization interface [polypeptide binding]; other site
639282002146	putative DNA binding site [nucleotide binding]; other site
639282002147	putative Zn2+ binding site [ion binding]; other site
639282002148	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
639282002149	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
639282002150	active site residue [active]
639282002151	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
639282002152	active site residue [active]
639282002153	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
639282002154	thiosulfate reductase PhsA; Provisional; Region: PRK15488
639282002155	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
639282002156	putative [Fe4-S4] binding site [ion binding]; other site
639282002157	putative molybdopterin cofactor binding site [chemical binding]; other site
639282002158	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
639282002159	putative molybdopterin cofactor binding site; other site
639282002160	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
639282002161	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
639282002162	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
639282002163	TPR repeat; Region: TPR_11; pfam13414
639282002164	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
639282002165	iron-sulfur cluster [ion binding]; other site
639282002166	[2Fe-2S] cluster binding site [ion binding]; other site
639282002167	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
639282002168	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
639282002169	heme bH binding site [chemical binding]; other site
639282002170	intrachain domain interface; other site
639282002171	Qi binding site; other site
639282002172	heme bL binding site [chemical binding]; other site
639282002173	interchain domain interface [polypeptide binding]; other site
639282002174	Qo binding site; other site
639282002175	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
639282002176	Cytochrome c; Region: Cytochrom_C; pfam00034
639282002177	Isochorismatase family; Region: Isochorismatase; pfam00857
639282002178	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
639282002179	catalytic triad [active]
639282002180	dimer interface [polypeptide binding]; other site
639282002181	conserved cis-peptide bond; other site
639282002182	aconitate hydratase; Validated; Region: PRK09277
639282002183	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
639282002184	substrate binding site [chemical binding]; other site
639282002185	ligand binding site [chemical binding]; other site
639282002186	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
639282002187	substrate binding site [chemical binding]; other site
639282002188	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
639282002189	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
639282002190	non-specific DNA binding site [nucleotide binding]; other site
639282002191	salt bridge; other site
639282002192	sequence-specific DNA binding site [nucleotide binding]; other site
639282002193	Cupin domain; Region: Cupin_2; pfam07883
639282002194	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
639282002195	tartrate dehydrogenase; Region: TTC; TIGR02089
639282002196	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
639282002197	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
639282002198	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
639282002199	DctM-like transporters; Region: DctM; pfam06808
639282002200	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
639282002201	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
639282002202	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
639282002203	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
639282002204	L-aspartate oxidase; Provisional; Region: PRK06175
639282002205	succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup; Region: sdhA_forward; TIGR01816
639282002206	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
639282002207	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
639282002208	Iron-sulfur protein interface; other site
639282002209	proximal heme binding site [chemical binding]; other site
639282002210	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282002211	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282002212	metal binding site [ion binding]; metal-binding site
639282002213	active site
639282002214	I-site; other site
639282002215	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
639282002216	AMMECR1; Region: AMMECR1; pfam01871
639282002217	4Fe-4S binding domain; Region: Fer4; pfam00037
639282002218	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
639282002219	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
639282002220	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
639282002221	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
639282002222	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
639282002223	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
639282002224	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
639282002225	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
639282002226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282002227	active site
639282002228	phosphorylation site [posttranslational modification]
639282002229	intermolecular recognition site; other site
639282002230	dimerization interface [polypeptide binding]; other site
639282002231	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
639282002232	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282002233	dimer interface [polypeptide binding]; other site
639282002234	putative CheW interface [polypeptide binding]; other site
639282002235	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
639282002236	putative binding surface; other site
639282002237	active site
639282002238	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282002239	ATP binding site [chemical binding]; other site
639282002240	Mg2+ binding site [ion binding]; other site
639282002241	G-X-G motif; other site
639282002242	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
639282002243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282002244	active site
639282002245	phosphorylation site [posttranslational modification]
639282002246	intermolecular recognition site; other site
639282002247	dimerization interface [polypeptide binding]; other site
639282002248	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
639282002249	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282002250	active site
639282002251	phosphorylation site [posttranslational modification]
639282002252	intermolecular recognition site; other site
639282002253	dimerization interface [polypeptide binding]; other site
639282002254	CheB methylesterase; Region: CheB_methylest; pfam01339
639282002255	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
639282002256	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
639282002257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
639282002258	TPR repeat; Region: TPR_11; pfam13414
639282002259	binding surface
639282002260	TPR motif; other site
639282002261	Response regulator receiver domain; Region: Response_reg; pfam00072
639282002262	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282002263	active site
639282002264	phosphorylation site [posttranslational modification]
639282002265	intermolecular recognition site; other site
639282002266	dimerization interface [polypeptide binding]; other site
639282002267	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282002268	short chain dehydrogenase; Provisional; Region: PRK08339
639282002269	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
639282002270	putative NAD(P) binding site [chemical binding]; other site
639282002271	putative active site [active]
639282002272	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
639282002273	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
639282002274	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
639282002275	Iron permease FTR1 family; Region: FTR1; cl00475
639282002276	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
639282002277	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
639282002278	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
639282002279	active site
639282002280	DNA binding site [nucleotide binding]
639282002281	Int/Topo IB signature motif; other site
639282002282	Helix-turn-helix domain; Region: HTH_17; pfam12728
639282002283	Helix-turn-helix domain; Region: HTH_17; cl17695
639282002284	Integrase; Region: Integrase_1; pfam12835
639282002285	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
639282002286	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
639282002287	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
639282002288	non-specific DNA binding site [nucleotide binding]; other site
639282002289	salt bridge; other site
639282002290	sequence-specific DNA binding site [nucleotide binding]; other site
639282002291	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
639282002292	Mg binding site [ion binding]; other site
639282002293	nucleotide binding site [chemical binding]; other site
639282002294	putative protofilament interface [polypeptide binding]; other site
639282002295	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
639282002296	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
639282002297	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
639282002298	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
639282002299	active site
639282002300	LssY C-terminus; Region: LssY_C; pfam14067
639282002301	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
639282002302	dimerization interface [polypeptide binding]; other site
639282002303	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282002304	dimer interface [polypeptide binding]; other site
639282002305	phosphorylation site [posttranslational modification]
639282002306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282002307	ATP binding site [chemical binding]; other site
639282002308	Mg2+ binding site [ion binding]; other site
639282002309	G-X-G motif; other site
639282002310	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
639282002311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282002312	active site
639282002313	phosphorylation site [posttranslational modification]
639282002314	intermolecular recognition site; other site
639282002315	dimerization interface [polypeptide binding]; other site
639282002316	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
639282002317	DNA binding site [nucleotide binding]
639282002318	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
639282002319	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
639282002320	active site
639282002321	Transposase domain (DUF772); Region: DUF772; pfam05598
639282002322	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
639282002323	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
639282002324	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
639282002325	amino acid transporter; Region: 2A0306; TIGR00909
639282002326	Predicted integral membrane protein [Function unknown]; Region: COG0392
639282002327	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
639282002328	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
639282002329	active site
639282002330	metal binding site [ion binding]; metal-binding site
639282002331	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
639282002332	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
639282002333	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
639282002334	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
639282002335	FecR protein; Region: FecR; pfam04773
639282002336	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
639282002337	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
639282002338	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
639282002339	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
639282002340	active site
639282002341	substrate binding site [chemical binding]; other site
639282002342	metal binding site [ion binding]; metal-binding site
639282002343	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
639282002344	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
639282002345	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
639282002346	Part of AAA domain; Region: AAA_19; pfam13245
639282002347	Family description; Region: UvrD_C_2; pfam13538
639282002348	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
639282002349	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
639282002350	AAA domain; Region: AAA_30; pfam13604
639282002351	Family description; Region: UvrD_C_2; pfam13538
639282002352	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282002353	metal binding site [ion binding]; metal-binding site
639282002354	active site
639282002355	I-site; other site
639282002356	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
639282002357	Response regulator receiver domain; Region: Response_reg; pfam00072
639282002358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282002359	active site
639282002360	phosphorylation site [posttranslational modification]
639282002361	intermolecular recognition site; other site
639282002362	dimerization interface [polypeptide binding]; other site
639282002363	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282002364	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282002365	metal binding site [ion binding]; metal-binding site
639282002366	active site
639282002367	I-site; other site
639282002368	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
639282002369	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
639282002370	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
639282002371	heme-binding residues [chemical binding]; other site
639282002372	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
639282002373	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
639282002374	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
639282002375	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002376	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
639282002377	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002378	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
639282002379	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
639282002380	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002381	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002382	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
639282002383	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002384	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002385	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002386	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002387	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282002388	binding surface
639282002389	TPR motif; other site
639282002390	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
639282002391	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002392	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002393	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002394	NHL repeat; Region: NHL; pfam01436
639282002395	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282002396	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282002397	dimer interface [polypeptide binding]; other site
639282002398	phosphorylation site [posttranslational modification]
639282002399	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282002400	ATP binding site [chemical binding]; other site
639282002401	Mg2+ binding site [ion binding]; other site
639282002402	G-X-G motif; other site
639282002403	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
639282002404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282002405	active site
639282002406	phosphorylation site [posttranslational modification]
639282002407	intermolecular recognition site; other site
639282002408	dimerization interface [polypeptide binding]; other site
639282002409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282002410	Walker A motif; other site
639282002411	ATP binding site [chemical binding]; other site
639282002412	Walker B motif; other site
639282002413	arginine finger; other site
639282002414	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
639282002415	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002416	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
639282002417	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002418	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
639282002419	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
639282002420	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
639282002421	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
639282002422	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282002423	Tetratricopeptide repeat; Region: TPR_16; pfam13432
639282002424	binding surface
639282002425	TPR motif; other site
639282002426	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
639282002427	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
639282002428	active site
639282002429	NAD binding site [chemical binding]; other site
639282002430	metal binding site [ion binding]; metal-binding site
639282002431	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
639282002432	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
639282002433	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
639282002434	acetylornithine deacetylase; Provisional; Region: PRK08652
639282002435	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
639282002436	metal binding site [ion binding]; metal-binding site
639282002437	dimer interface [polypeptide binding]; other site
639282002438	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
639282002439	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
639282002440	Coenzyme A binding pocket [chemical binding]; other site
639282002441	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
639282002442	Predicted transcriptional regulators [Transcription]; Region: COG1725
639282002443	DNA-binding site [nucleotide binding]; DNA binding site
639282002444	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
639282002445	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
639282002446	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
639282002447	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
639282002448	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
639282002449	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
639282002450	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
639282002451	DctM-like transporters; Region: DctM; pfam06808
639282002452	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
639282002453	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
639282002454	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
639282002455	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
639282002456	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
639282002457	Lysine efflux permease [General function prediction only]; Region: COG1279
639282002458	hybrid cluster protein; Provisional; Region: PRK05290
639282002459	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
639282002460	ACS interaction site; other site
639282002461	CODH interaction site; other site
639282002462	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
639282002463	hybrid metal cluster; other site
639282002464	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
639282002465	putative hydrophobic ligand binding site [chemical binding]; other site
639282002466	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
639282002467	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
639282002468	NAD(P) binding site [chemical binding]; other site
639282002469	active site
639282002470	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
639282002471	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
639282002472	active site
639282002473	hypothetical protein; Provisional; Region: PRK06361
639282002474	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
639282002475	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
639282002476	dimer interface [polypeptide binding]; other site
639282002477	PYR/PP interface [polypeptide binding]; other site
639282002478	TPP binding site [chemical binding]; other site
639282002479	substrate binding site [chemical binding]; other site
639282002480	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
639282002481	TPP-binding site; other site
639282002482	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
639282002483	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
639282002484	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
639282002485	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
639282002486	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
639282002487	active site
639282002488	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
639282002489	PAS domain; Region: PAS; smart00091
639282002490	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
639282002491	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
639282002492	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
639282002493	putative active site [active]
639282002494	heme pocket [chemical binding]; other site
639282002495	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
639282002496	putative active site [active]
639282002497	heme pocket [chemical binding]; other site
639282002498	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282002499	dimer interface [polypeptide binding]; other site
639282002500	phosphorylation site [posttranslational modification]
639282002501	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282002502	ATP binding site [chemical binding]; other site
639282002503	Mg2+ binding site [ion binding]; other site
639282002504	G-X-G motif; other site
639282002505	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
639282002506	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282002507	active site
639282002508	phosphorylation site [posttranslational modification]
639282002509	intermolecular recognition site; other site
639282002510	dimerization interface [polypeptide binding]; other site
639282002511	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
639282002512	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
639282002513	Transcriptional regulator [Transcription]; Region: IclR; COG1414
639282002514	Bacterial transcriptional regulator; Region: IclR; pfam01614
639282002515	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
639282002516	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
639282002517	Soluble P-type ATPase [General function prediction only]; Region: COG4087
639282002518	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
639282002519	dimerization interface [polypeptide binding]; other site
639282002520	putative DNA binding site [nucleotide binding]; other site
639282002521	putative Zn2+ binding site [ion binding]; other site
639282002522	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
639282002523	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
639282002524	HIGH motif; other site
639282002525	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
639282002526	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
639282002527	active site
639282002528	KMSKS motif; other site
639282002529	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
639282002530	tRNA binding surface [nucleotide binding]; other site
639282002531	Lipopolysaccharide-assembly; Region: LptE; cl01125
639282002532	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
639282002533	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
639282002534	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
639282002535	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
639282002536	active site
639282002537	catalytic residues [active]
639282002538	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282002539	dimerization interface [polypeptide binding]; other site
639282002540	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
639282002541	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282002542	dimer interface [polypeptide binding]; other site
639282002543	putative CheW interface [polypeptide binding]; other site
639282002544	Protein of unknown function (DUF493); Region: DUF493; cl01102
639282002545	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
639282002546	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
639282002547	B12 binding site [chemical binding]; other site
639282002548	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282002549	FeS/SAM binding site; other site
639282002550	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
639282002551	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
639282002552	active site residues [active]
639282002553	dimer interface [polypeptide binding]; other site
639282002554	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
639282002555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282002556	S-adenosylmethionine binding site [chemical binding]; other site
639282002557	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
639282002558	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
639282002559	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
639282002560	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
639282002561	TPP-binding site [chemical binding]; other site
639282002562	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
639282002563	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
639282002564	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
639282002565	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
639282002566	dimer interface [polypeptide binding]; other site
639282002567	PYR/PP interface [polypeptide binding]; other site
639282002568	TPP binding site [chemical binding]; other site
639282002569	substrate binding site [chemical binding]; other site
639282002570	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
639282002571	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
639282002572	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
639282002573	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
639282002574	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
639282002575	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
639282002576	tRNA; other site
639282002577	putative tRNA binding site [nucleotide binding]; other site
639282002578	putative NADP binding site [chemical binding]; other site
639282002579	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
639282002580	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
639282002581	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
639282002582	domain interfaces; other site
639282002583	active site
639282002584	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
639282002585	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
639282002586	active site
639282002587	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
639282002588	dimer interface [polypeptide binding]; other site
639282002589	active site
639282002590	Schiff base residues; other site
639282002591	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
639282002592	Walker A motif; other site
639282002593	ATP binding site [chemical binding]; other site
639282002594	type I citrate synthase; Reviewed; Region: PRK09569
639282002595	citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793
639282002596	oxalacetate binding site [chemical binding]; other site
639282002597	citrylCoA binding site [chemical binding]; other site
639282002598	coenzyme A binding site [chemical binding]; other site
639282002599	catalytic triad [active]
639282002600	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
639282002601	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
639282002602	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
639282002603	minor groove reading motif; other site
639282002604	helix-hairpin-helix signature motif; other site
639282002605	active site
639282002606	Transglycosylase SLT domain; Region: SLT_2; pfam13406
639282002607	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
639282002608	N-acetyl-D-glucosamine binding site [chemical binding]; other site
639282002609	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
639282002610	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
639282002611	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
639282002612	putative MPT binding site; other site
639282002613	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
639282002614	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282002615	Walker A/P-loop; other site
639282002616	ATP binding site [chemical binding]; other site
639282002617	Q-loop/lid; other site
639282002618	ABC transporter signature motif; other site
639282002619	Walker B; other site
639282002620	D-loop; other site
639282002621	H-loop/switch region; other site
639282002622	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
639282002623	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
639282002624	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
639282002625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282002626	dimer interface [polypeptide binding]; other site
639282002627	conserved gate region; other site
639282002628	putative PBP binding loops; other site
639282002629	ABC-ATPase subunit interface; other site
639282002630	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
639282002631	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
639282002632	dimer interface [polypeptide binding]; other site
639282002633	putative functional site; other site
639282002634	putative MPT binding site; other site
639282002635	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282002636	Radical SAM superfamily; Region: Radical_SAM; pfam04055
639282002637	FeS/SAM binding site; other site
639282002638	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
639282002639	Ferritin-like domain; Region: Ferritin; pfam00210
639282002640	ferroxidase diiron center [ion binding]; other site
639282002641	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
639282002642	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
639282002643	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
639282002644	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282002645	binding surface
639282002646	TPR motif; other site
639282002647	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
639282002648	Tetratricopeptide repeat; Region: TPR_6; pfam13174
639282002649	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282002650	dimer interface [polypeptide binding]; other site
639282002651	phosphorylation site [posttranslational modification]
639282002652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282002653	ATP binding site [chemical binding]; other site
639282002654	Mg2+ binding site [ion binding]; other site
639282002655	G-X-G motif; other site
639282002656	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
639282002657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282002658	active site
639282002659	phosphorylation site [posttranslational modification]
639282002660	intermolecular recognition site; other site
639282002661	dimerization interface [polypeptide binding]; other site
639282002662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282002663	Walker A motif; other site
639282002664	ATP binding site [chemical binding]; other site
639282002665	Walker B motif; other site
639282002666	arginine finger; other site
639282002667	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
639282002668	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
639282002669	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
639282002670	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
639282002671	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
639282002672	NAD(P) binding site [chemical binding]; other site
639282002673	active site
639282002674	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
639282002675	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
639282002676	active site
639282002677	HIGH motif; other site
639282002678	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
639282002679	KMSKS motif; other site
639282002680	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
639282002681	tRNA binding surface [nucleotide binding]; other site
639282002682	anticodon binding site; other site
639282002683	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
639282002684	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
639282002685	Walker A/P-loop; other site
639282002686	ATP binding site [chemical binding]; other site
639282002687	Q-loop/lid; other site
639282002688	ABC transporter signature motif; other site
639282002689	Walker B; other site
639282002690	D-loop; other site
639282002691	H-loop/switch region; other site
639282002692	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
639282002693	dihydroorotase; Validated; Region: pyrC; PRK09357
639282002694	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
639282002695	active site
639282002696	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
639282002697	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
639282002698	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
639282002699	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
639282002700	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
639282002701	active site
639282002702	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
639282002703	oligomerization interface [polypeptide binding]; other site
639282002704	active site
639282002705	metal binding site [ion binding]; metal-binding site
639282002706	Pantoate-beta-alanine ligase; Region: PanC; cd00560
639282002707	pantoate--beta-alanine ligase; Region: panC; TIGR00018
639282002708	active site
639282002709	ATP-binding site [chemical binding]; other site
639282002710	pantoate-binding site; other site
639282002711	HXXH motif; other site
639282002712	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
639282002713	tetramerization interface [polypeptide binding]; other site
639282002714	active site
639282002715	Hemerythrin; Region: Hemerythrin; cd12107
639282002716	Fe binding site [ion binding]; other site
639282002717	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
639282002718	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282002719	dimerization interface [polypeptide binding]; other site
639282002720	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282002721	dimer interface [polypeptide binding]; other site
639282002722	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
639282002723	putative CheW interface [polypeptide binding]; other site
639282002724	Protein of unknown function (DUF342); Region: DUF342; pfam03961
639282002725	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
639282002726	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
639282002727	ligand binding site [chemical binding]; other site
639282002728	flexible hinge region; other site
639282002729	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
639282002730	dinuclear metal binding motif [ion binding]; other site
639282002731	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
639282002732	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
639282002733	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
639282002734	FOG: CBS domain [General function prediction only]; Region: COG0517
639282002735	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
639282002736	acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188
639282002737	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
639282002738	acyl-activating enzyme (AAE) consensus motif; other site
639282002739	AMP binding site [chemical binding]; other site
639282002740	active site
639282002741	CoA binding site [chemical binding]; other site
639282002742	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
639282002743	Active_site [active]
639282002744	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
639282002745	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
639282002746	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
639282002747	ligand binding site [chemical binding]; other site
639282002748	NAD binding site [chemical binding]; other site
639282002749	dimerization interface [polypeptide binding]; other site
639282002750	catalytic site [active]
639282002751	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
639282002752	putative L-serine binding site [chemical binding]; other site
639282002753	Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963
639282002754	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
639282002755	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
639282002756	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282002757	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
639282002758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282002759	active site
639282002760	phosphorylation site [posttranslational modification]
639282002761	intermolecular recognition site; other site
639282002762	dimerization interface [polypeptide binding]; other site
639282002763	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
639282002764	DNA binding site [nucleotide binding]
639282002765	Cache domain; Region: Cache_1; pfam02743
639282002766	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282002767	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282002768	metal binding site [ion binding]; metal-binding site
639282002769	active site
639282002770	I-site; other site
639282002771	Integrase; Region: Integrase_1; pfam12835
639282002772	Transposase, Mutator family; Region: Transposase_mut; pfam00872
639282002773	MULE transposase domain; Region: MULE; pfam10551
639282002774	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
639282002775	Mg binding site [ion binding]; other site
639282002776	nucleotide binding site [chemical binding]; other site
639282002777	putative protofilament interface [polypeptide binding]; other site
639282002778	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
639282002779	Superfamily II helicase [General function prediction only]; Region: COG1204
639282002780	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
639282002781	ATP binding site [chemical binding]; other site
639282002782	putative Mg++ binding site [ion binding]; other site
639282002783	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
639282002784	AAA domain; Region: AAA_14; pfam13173
639282002785	AAA domain; Region: AAA_22; pfam13401
639282002786	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
639282002787	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
639282002788	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
639282002789	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
639282002790	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
639282002791	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
639282002792	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
639282002793	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
639282002794	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
639282002795	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
639282002796	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
639282002797	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
639282002798	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
639282002799	Predicted transcriptional regulator [Transcription]; Region: COG2378
639282002800	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
639282002801	WYL domain; Region: WYL; pfam13280
639282002802	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
639282002803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282002804	Walker A motif; other site
639282002805	ATP binding site [chemical binding]; other site
639282002806	Walker B motif; other site
639282002807	arginine finger; other site
639282002808	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
639282002809	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
639282002810	active site
639282002811	PHP Thumb interface [polypeptide binding]; other site
639282002812	metal binding site [ion binding]; metal-binding site
639282002813	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
639282002814	Pseudogene. Similar to conserved hypothetical protein. This CDS appears to have a frameshift mutation
639282002815	Probable gene remnant. Similar to the N-terminal region of Legionella pneumophila (strain Lens) conserved hypothetical protein (291 aa) lpl0068.
639282002816	Probable gene remnant. Similar to the C-terminal region of Legionella pneumophila (strain Lens) conserved hypothetical protein (291 aa) lpl0068.
639282002817	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
639282002818	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
639282002819	PemK-like protein; Region: PemK; cl00995
639282002820	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
639282002821	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
639282002822	Zn binding site [ion binding]; other site
639282002823	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
639282002824	active site
639282002825	catalytic residues [active]
639282002826	DNA binding site [nucleotide binding]
639282002827	Int/Topo IB signature motif; other site
639282002828	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
639282002829	four helix bundle protein; Region: TIGR02436
639282002830	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
639282002831	FOG: WD40 repeat [General function prediction only]; Region: COG2319
639282002832	Caspase domain; Region: Peptidase_C14; pfam00656
639282002833	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
639282002834	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
639282002835	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
639282002836	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
639282002837	putative catalytic residues [active]
639282002838	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
639282002839	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
639282002840	motif II; other site
639282002841	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
639282002842	metal-binding site [ion binding]
639282002843	mercuric reductase; Region: MerA; TIGR02053
639282002844	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
639282002845	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
639282002846	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
639282002847	MerT mercuric transport protein; Region: MerT; cl03578
639282002848	Pseudogene. Similar to transcriptional regulator, MerR family. This CDS appears to have a frameshift mutation
639282002849	Probable gene remnant. Similar to the C-terminal region of Rhizobium meliloti (Sinorhizobium meliloti) heavy metal-dependent transcription regulator 1 (147 aa) RA0549.
639282002850	Probable gene remnant. Similar to the N-terminal region of Rhizobium meliloti (Sinorhizobium meliloti) heavy metal-dependent transcription regulator 1 (147 aa) RA0549.
639282002851	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
639282002852	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
639282002853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282002854	homodimer interface [polypeptide binding]; other site
639282002855	catalytic residue [active]
639282002856	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
639282002857	Short C-terminal domain; Region: SHOCT; pfam09851
639282002858	Fumarase C-terminus; Region: Fumerase_C; pfam05683
639282002859	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
639282002860	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
639282002861	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
639282002862	substrate binding site [chemical binding]; other site
639282002863	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
639282002864	substrate binding site [chemical binding]; other site
639282002865	ligand binding site [chemical binding]; other site
639282002866	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
639282002867	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
639282002868	malate dehydrogenase; Reviewed; Region: PRK06223
639282002869	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
639282002870	NAD(P) binding site [chemical binding]; other site
639282002871	dimer interface [polypeptide binding]; other site
639282002872	tetramer (dimer of dimers) interface [polypeptide binding]; other site
639282002873	substrate binding site [chemical binding]; other site
639282002874	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
639282002875	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
639282002876	Protein of unknown function (DUF3826); Region: DUF3826; pfam12875
639282002877	CoA-ligase; Region: Ligase_CoA; pfam00549
639282002878	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
639282002879	CoA binding domain; Region: CoA_binding; smart00881
639282002880	CoA-ligase; Region: Ligase_CoA; pfam00549
639282002881	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
639282002882	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
639282002883	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
639282002884	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
639282002885	dimer interface [polypeptide binding]; other site
639282002886	PYR/PP interface [polypeptide binding]; other site
639282002887	TPP binding site [chemical binding]; other site
639282002888	substrate binding site [chemical binding]; other site
639282002889	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
639282002890	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
639282002891	TPP-binding site [chemical binding]; other site
639282002892	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
639282002893	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
639282002894	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
639282002895	Predicted permeases [General function prediction only]; Region: RarD; COG2962
639282002896	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
639282002897	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
639282002898	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
639282002899	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
639282002900	TM-ABC transporter signature motif; other site
639282002901	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
639282002902	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
639282002903	TM-ABC transporter signature motif; other site
639282002904	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
639282002905	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
639282002906	Walker A/P-loop; other site
639282002907	ATP binding site [chemical binding]; other site
639282002908	Q-loop/lid; other site
639282002909	ABC transporter signature motif; other site
639282002910	Walker B; other site
639282002911	D-loop; other site
639282002912	H-loop/switch region; other site
639282002913	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
639282002914	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
639282002915	Walker A/P-loop; other site
639282002916	ATP binding site [chemical binding]; other site
639282002917	Q-loop/lid; other site
639282002918	ABC transporter signature motif; other site
639282002919	Walker B; other site
639282002920	D-loop; other site
639282002921	H-loop/switch region; other site
639282002922	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
639282002923	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
639282002924	DNA-binding site [nucleotide binding]; DNA binding site
639282002925	UTRA domain; Region: UTRA; pfam07702
639282002926	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
639282002927	active sites [active]
639282002928	tetramer interface [polypeptide binding]; other site
639282002929	urocanate hydratase; Provisional; Region: PRK05414
639282002930	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
639282002931	formimidoylglutamase; Provisional; Region: PRK13775
639282002932	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
639282002933	putative active site [active]
639282002934	putative metal binding site [ion binding]; other site
639282002935	imidazolonepropionase; Validated; Region: PRK09356
639282002936	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
639282002937	active site
639282002938	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
639282002939	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
639282002940	Ligand Binding Site [chemical binding]; other site
639282002941	6-phosphofructokinase; Provisional; Region: PRK03202
639282002942	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
639282002943	active site
639282002944	ADP/pyrophosphate binding site [chemical binding]; other site
639282002945	dimerization interface [polypeptide binding]; other site
639282002946	allosteric effector site; other site
639282002947	fructose-1,6-bisphosphate binding site; other site
639282002948	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
639282002949	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
639282002950	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
639282002951	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
639282002952	RNA binding surface [nucleotide binding]; other site
639282002953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282002954	S-adenosylmethionine binding site [chemical binding]; other site
639282002955	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
639282002956	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
639282002957	TPP-binding site; other site
639282002958	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
639282002959	PYR/PP interface [polypeptide binding]; other site
639282002960	dimer interface [polypeptide binding]; other site
639282002961	TPP binding site [chemical binding]; other site
639282002962	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
639282002963	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
639282002964	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
639282002965	substrate binding pocket [chemical binding]; other site
639282002966	chain length determination region; other site
639282002967	substrate-Mg2+ binding site; other site
639282002968	catalytic residues [active]
639282002969	aspartate-rich region 1; other site
639282002970	active site lid residues [active]
639282002971	aspartate-rich region 2; other site
639282002972	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
639282002973	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
639282002974	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
639282002975	catalytic triad [active]
639282002976	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
639282002977	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
639282002978	FeS/SAM binding site; other site
639282002979	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282002980	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282002981	metal binding site [ion binding]; metal-binding site
639282002982	active site
639282002983	I-site; other site
639282002984	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
639282002985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282002986	S-adenosylmethionine binding site [chemical binding]; other site
639282002987	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
639282002988	anti sigma factor interaction site; other site
639282002989	regulatory phosphorylation site [posttranslational modification]; other site
639282002990	Flagellar protein YcgR; Region: YcgR_2; pfam12945
639282002991	PilZ domain; Region: PilZ; pfam07238
639282002992	Response regulator receiver domain; Region: Response_reg; pfam00072
639282002993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282002994	active site
639282002995	phosphorylation site [posttranslational modification]
639282002996	intermolecular recognition site; other site
639282002997	dimerization interface [polypeptide binding]; other site
639282002998	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282002999	dimer interface [polypeptide binding]; other site
639282003000	phosphorylation site [posttranslational modification]
639282003001	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282003002	ATP binding site [chemical binding]; other site
639282003003	G-X-G motif; other site
639282003004	Response regulator receiver domain; Region: Response_reg; pfam00072
639282003005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282003006	active site
639282003007	phosphorylation site [posttranslational modification]
639282003008	intermolecular recognition site; other site
639282003009	dimerization interface [polypeptide binding]; other site
639282003010	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
639282003011	EamA-like transporter family; Region: EamA; pfam00892
639282003012	HD domain; Region: HD_3; pfam13023
639282003013	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
639282003014	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
639282003015	acyl-activating enzyme (AAE) consensus motif; other site
639282003016	AMP binding site [chemical binding]; other site
639282003017	active site
639282003018	CoA binding site [chemical binding]; other site
639282003019	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
639282003020	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
639282003021	Walker A/P-loop; other site
639282003022	ATP binding site [chemical binding]; other site
639282003023	Q-loop/lid; other site
639282003024	ABC transporter signature motif; other site
639282003025	Walker B; other site
639282003026	D-loop; other site
639282003027	H-loop/switch region; other site
639282003028	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
639282003029	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
639282003030	Walker A/P-loop; other site
639282003031	ATP binding site [chemical binding]; other site
639282003032	Q-loop/lid; other site
639282003033	ABC transporter signature motif; other site
639282003034	Walker B; other site
639282003035	D-loop; other site
639282003036	H-loop/switch region; other site
639282003037	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
639282003038	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
639282003039	TM-ABC transporter signature motif; other site
639282003040	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
639282003041	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
639282003042	TM-ABC transporter signature motif; other site
639282003043	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
639282003044	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
639282003045	putative ligand binding site [chemical binding]; other site
639282003046	ACT domain-containing protein [General function prediction only]; Region: COG4747
639282003047	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
639282003048	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
639282003049	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
639282003050	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
639282003051	acyl-activating enzyme (AAE) consensus motif; other site
639282003052	AMP binding site [chemical binding]; other site
639282003053	active site
639282003054	CoA binding site [chemical binding]; other site
639282003055	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
639282003056	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
639282003057	non-specific DNA binding site [nucleotide binding]; other site
639282003058	salt bridge; other site
639282003059	sequence-specific DNA binding site [nucleotide binding]; other site
639282003060	Cupin domain; Region: Cupin_2; pfam07883
639282003061	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
639282003062	IHF dimer interface [polypeptide binding]; other site
639282003063	IHF - DNA interface [nucleotide binding]; other site
639282003064	agmatinase; Region: agmatinase; TIGR01230
639282003065	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
639282003066	putative active site [active]
639282003067	Mn binding site [ion binding]; other site
639282003068	spermidine synthase; Provisional; Region: PRK00811
639282003069	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282003070	S-adenosylmethionine binding site [chemical binding]; other site
639282003071	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
639282003072	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
639282003073	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
639282003074	NADP binding site [chemical binding]; other site
639282003075	homopentamer interface [polypeptide binding]; other site
639282003076	substrate binding site [chemical binding]; other site
639282003077	active site
639282003078	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
639282003079	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
639282003080	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
639282003081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282003082	S-adenosylmethionine binding site [chemical binding]; other site
639282003083	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
639282003084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282003085	active site
639282003086	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
639282003087	phosphorylation site [posttranslational modification]
639282003088	intermolecular recognition site; other site
639282003089	dimerization interface [polypeptide binding]; other site
639282003090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282003091	active site
639282003092	phosphorylation site [posttranslational modification]
639282003093	intermolecular recognition site; other site
639282003094	dimerization interface [polypeptide binding]; other site
639282003095	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282003096	metal binding site [ion binding]; metal-binding site
639282003097	active site
639282003098	I-site; other site
639282003099	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
639282003100	SnoaL-like domain; Region: SnoaL_3; pfam13474
639282003101	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
639282003102	active site
639282003103	Zn binding site [ion binding]; other site
639282003104	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
639282003105	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
639282003106	putative ligand binding site [chemical binding]; other site
639282003107	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
639282003108	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
639282003109	Walker A/P-loop; other site
639282003110	ATP binding site [chemical binding]; other site
639282003111	Q-loop/lid; other site
639282003112	ABC transporter signature motif; other site
639282003113	Walker B; other site
639282003114	D-loop; other site
639282003115	H-loop/switch region; other site
639282003116	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
639282003117	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
639282003118	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
639282003119	TM-ABC transporter signature motif; other site
639282003120	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
639282003121	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
639282003122	TM-ABC transporter signature motif; other site
639282003123	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
639282003124	active site
639282003125	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282003126	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282003127	dimerization interface [polypeptide binding]; other site
639282003128	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282003129	dimer interface [polypeptide binding]; other site
639282003130	phosphorylation site [posttranslational modification]
639282003131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282003132	ATP binding site [chemical binding]; other site
639282003133	Mg2+ binding site [ion binding]; other site
639282003134	G-X-G motif; other site
639282003135	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
639282003136	Ligand binding site; other site
639282003137	Putative Catalytic site; other site
639282003138	DXD motif; other site
639282003139	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
639282003140	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
639282003141	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
639282003142	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
639282003143	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
639282003144	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
639282003145	putative active site [active]
639282003146	catalytic triad [active]
639282003147	putative dimer interface [polypeptide binding]; other site
639282003148	twin arginine translocase protein A; Provisional; Region: tatA; PRK14859
639282003149	Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638
639282003150	Cobalt transport protein; Region: CbiQ; cl00463
639282003151	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
639282003152	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
639282003153	dimerization interface 3.5A [polypeptide binding]; other site
639282003154	active site
639282003155	HDOD domain; Region: HDOD; pfam08668
639282003156	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282003157	Zn2+ binding site [ion binding]; other site
639282003158	Mg2+ binding site [ion binding]; other site
639282003159	PAS fold; Region: PAS; pfam00989
639282003160	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
639282003161	putative active site [active]
639282003162	heme pocket [chemical binding]; other site
639282003163	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
639282003164	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
639282003165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282003166	ATP binding site [chemical binding]; other site
639282003167	Mg2+ binding site [ion binding]; other site
639282003168	G-X-G motif; other site
639282003169	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282003170	active site
639282003171	phosphorylation site [posttranslational modification]
639282003172	intermolecular recognition site; other site
639282003173	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
639282003174	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282003175	FeS/SAM binding site; other site
639282003176	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
639282003177	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
639282003178	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
639282003179	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
639282003180	catalytic residue [active]
639282003181	YGGT family; Region: YGGT; pfam02325
639282003182	Ion channel; Region: Ion_trans_2; pfam07885
639282003183	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
639282003184	TrkA-N domain; Region: TrkA_N; pfam02254
639282003185	TrkA-C domain; Region: TrkA_C; pfam02080
639282003186	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
639282003187	putative active site [active]
639282003188	TRAM domain; Region: TRAM; cl01282
639282003189	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
639282003190	substrate binding site; other site
639282003191	dimer interface; other site
639282003192	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
639282003193	Peptidase family M50; Region: Peptidase_M50; pfam02163
639282003194	active site
639282003195	putative substrate binding region [chemical binding]; other site
639282003196	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
639282003197	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
639282003198	active site
639282003199	HIGH motif; other site
639282003200	dimer interface [polypeptide binding]; other site
639282003201	KMSKS motif; other site
639282003202	ScpA/B protein; Region: ScpA_ScpB; cl00598
639282003203	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
639282003204	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
639282003205	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
639282003206	RNA binding surface [nucleotide binding]; other site
639282003207	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
639282003208	active site
639282003209	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
639282003210	active site
639282003211	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
639282003212	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
639282003213	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282003214	TPR motif; other site
639282003215	binding surface
639282003216	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282003217	binding surface
639282003218	TPR motif; other site
639282003219	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
639282003220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282003221	Walker A motif; other site
639282003222	ATP binding site [chemical binding]; other site
639282003223	Walker B motif; other site
639282003224	arginine finger; other site
639282003225	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282003226	dimerization interface [polypeptide binding]; other site
639282003227	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
639282003228	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282003229	dimer interface [polypeptide binding]; other site
639282003230	phosphorylation site [posttranslational modification]
639282003231	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282003232	ATP binding site [chemical binding]; other site
639282003233	Mg2+ binding site [ion binding]; other site
639282003234	G-X-G motif; other site
639282003235	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
639282003236	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282003237	active site
639282003238	phosphorylation site [posttranslational modification]
639282003239	intermolecular recognition site; other site
639282003240	dimerization interface [polypeptide binding]; other site
639282003241	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282003242	Walker A motif; other site
639282003243	ATP binding site [chemical binding]; other site
639282003244	Walker B motif; other site
639282003245	arginine finger; other site
639282003246	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
639282003247	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
639282003248	hypothetical protein; Provisional; Region: PRK08609
639282003249	active site
639282003250	primer binding site [nucleotide binding]; other site
639282003251	NTP  binding site [chemical binding]; other site
639282003252	metal binding triad [ion binding]; metal-binding site
639282003253	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
639282003254	active site
639282003255	putative oxidoreductase; Provisional; Region: PRK12831
639282003256	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
639282003257	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
639282003258	active site
639282003259	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
639282003260	4Fe-4S binding domain; Region: Fer4; pfam00037
639282003261	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
639282003262	phosphate binding site [ion binding]; other site
639282003263	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
639282003264	domain_subunit interface; other site
639282003265	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
639282003266	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
639282003267	GTP binding site; other site
639282003268	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
639282003269	Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172
639282003270	non-heme iron binding site [ion binding]; other site
639282003271	tetramer interface [polypeptide binding]; other site
639282003272	YceG-like family; Region: YceG; pfam02618
639282003273	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
639282003274	dimerization interface [polypeptide binding]; other site
639282003275	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
639282003276	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
639282003277	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
639282003278	catalytic site [active]
639282003279	subunit interface [polypeptide binding]; other site
639282003280	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
639282003281	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
639282003282	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
639282003283	protein binding site [polypeptide binding]; other site
639282003284	PDZ domain; Region: PDZ_2; pfam13180
639282003285	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
639282003286	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
639282003287	dimer interface [polypeptide binding]; other site
639282003288	putative functional site; other site
639282003289	putative MPT binding site; other site
639282003290	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
639282003291	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494
639282003292	Walker A motif; other site
639282003293	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
639282003294	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
639282003295	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
639282003296	Walker A motif; other site
639282003297	ATP binding site [chemical binding]; other site
639282003298	Walker B motif; other site
639282003299	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
639282003300	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
639282003301	active site
639282003302	dimer interface [polypeptide binding]; other site
639282003303	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
639282003304	dimer interface [polypeptide binding]; other site
639282003305	active site
639282003306	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
639282003307	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
639282003308	Ligand Binding Site [chemical binding]; other site
639282003309	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
639282003310	active site
639282003311	FtsH Extracellular; Region: FtsH_ext; pfam06480
639282003312	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
639282003313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282003314	Walker A motif; other site
639282003315	ATP binding site [chemical binding]; other site
639282003316	Walker B motif; other site
639282003317	arginine finger; other site
639282003318	Peptidase family M41; Region: Peptidase_M41; pfam01434
639282003319	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
639282003320	dihydropteroate synthase; Region: DHPS; TIGR01496
639282003321	substrate binding pocket [chemical binding]; other site
639282003322	dimer interface [polypeptide binding]; other site
639282003323	inhibitor binding site; inhibition site
639282003324	Uncharacterized conserved protein [Function unknown]; Region: COG1624
639282003325	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
639282003326	YbbR-like protein; Region: YbbR; pfam07949
639282003327	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
639282003328	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
639282003329	active site
639282003330	substrate binding site [chemical binding]; other site
639282003331	metal binding site [ion binding]; metal-binding site
639282003332	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
639282003333	active site
639282003334	hydrophilic channel; other site
639282003335	dimerization interface [polypeptide binding]; other site
639282003336	catalytic residues [active]
639282003337	active site lid [active]
639282003338	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
639282003339	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
639282003340	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
639282003341	active site
639282003342	CTP synthetase; Validated; Region: pyrG; PRK05380
639282003343	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
639282003344	Catalytic site [active]
639282003345	active site
639282003346	UTP binding site [chemical binding]; other site
639282003347	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
639282003348	active site
639282003349	putative oxyanion hole; other site
639282003350	catalytic triad [active]
639282003351	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
639282003352	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
639282003353	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
639282003354	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
639282003355	putative active site [active]
639282003356	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
639282003357	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
639282003358	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
639282003359	active site
639282003360	motif I; other site
639282003361	motif II; other site
639282003362	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
639282003363	OstA-like protein; Region: OstA; pfam03968
639282003364	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
639282003365	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
639282003366	Walker A/P-loop; other site
639282003367	ATP binding site [chemical binding]; other site
639282003368	Q-loop/lid; other site
639282003369	ABC transporter signature motif; other site
639282003370	Walker B; other site
639282003371	D-loop; other site
639282003372	H-loop/switch region; other site
639282003373	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
639282003374	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
639282003375	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
639282003376	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
639282003377	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
639282003378	30S subunit binding site; other site
639282003379	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
639282003380	active site
639282003381	phosphorylation site [posttranslational modification]
639282003382	HPr kinase/phosphorylase; Provisional; Region: PRK05428
639282003383	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
639282003384	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
639282003385	Hpr binding site; other site
639282003386	active site
639282003387	homohexamer subunit interaction site [polypeptide binding]; other site
639282003388	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
639282003389	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
639282003390	active site
639282003391	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
639282003392	active pocket/dimerization site; other site
639282003393	active site
639282003394	phosphorylation site [posttranslational modification]
639282003395	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
639282003396	active site
639282003397	phosphorylation site [posttranslational modification]
639282003398	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
639282003399	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
639282003400	dimerization domain swap beta strand [polypeptide binding]; other site
639282003401	regulatory protein interface [polypeptide binding]; other site
639282003402	active site
639282003403	regulatory phosphorylation site [posttranslational modification]; other site
639282003404	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
639282003405	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
639282003406	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
639282003407	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
639282003408	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
639282003409	putative active site pocket [active]
639282003410	dimerization interface [polypeptide binding]; other site
639282003411	putative catalytic residue [active]
639282003412	SurA N-terminal domain; Region: SurA_N_3; pfam13624
639282003413	periplasmic folding chaperone; Provisional; Region: PRK10788
639282003414	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
639282003415	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
639282003416	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
639282003417	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
639282003418	DNA binding residues [nucleotide binding]
639282003419	Putative zinc-finger; Region: zf-HC2; pfam13490
639282003420	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
639282003421	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
639282003422	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
639282003423	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
639282003424	protein binding site [polypeptide binding]; other site
639282003425	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
639282003426	protein binding site [polypeptide binding]; other site
639282003427	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
639282003428	sequence-specific DNA binding site [nucleotide binding]; other site
639282003429	salt bridge; other site
639282003430	Cupin domain; Region: Cupin_2; pfam07883
639282003431	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
639282003432	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
639282003433	putative ligand binding site [chemical binding]; other site
639282003434	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
639282003435	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
639282003436	TM-ABC transporter signature motif; other site
639282003437	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
639282003438	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
639282003439	TM-ABC transporter signature motif; other site
639282003440	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
639282003441	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
639282003442	Walker A/P-loop; other site
639282003443	ATP binding site [chemical binding]; other site
639282003444	Q-loop/lid; other site
639282003445	ABC transporter signature motif; other site
639282003446	Walker B; other site
639282003447	D-loop; other site
639282003448	H-loop/switch region; other site
639282003449	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
639282003450	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
639282003451	Walker A/P-loop; other site
639282003452	ATP binding site [chemical binding]; other site
639282003453	Q-loop/lid; other site
639282003454	ABC transporter signature motif; other site
639282003455	Walker B; other site
639282003456	D-loop; other site
639282003457	H-loop/switch region; other site
639282003458	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
639282003459	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
639282003460	Glutamate binding site [chemical binding]; other site
639282003461	NAD binding site [chemical binding]; other site
639282003462	catalytic residues [active]
639282003463	Proline dehydrogenase; Region: Pro_dh; cl03282
639282003464	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
639282003465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282003466	active site
639282003467	phosphorylation site [posttranslational modification]
639282003468	intermolecular recognition site; other site
639282003469	Response regulator receiver domain; Region: Response_reg; pfam00072
639282003470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282003471	active site
639282003472	phosphorylation site [posttranslational modification]
639282003473	intermolecular recognition site; other site
639282003474	dimerization interface [polypeptide binding]; other site
639282003475	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282003476	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282003477	metal binding site [ion binding]; metal-binding site
639282003478	active site
639282003479	I-site; other site
639282003480	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
639282003481	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
639282003482	HIGH motif; other site
639282003483	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
639282003484	active site
639282003485	KMSKS motif; other site
639282003486	GTP-binding protein Der; Reviewed; Region: PRK00093
639282003487	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
639282003488	G1 box; other site
639282003489	GTP/Mg2+ binding site [chemical binding]; other site
639282003490	Switch I region; other site
639282003491	G2 box; other site
639282003492	Switch II region; other site
639282003493	G3 box; other site
639282003494	G4 box; other site
639282003495	G5 box; other site
639282003496	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
639282003497	G1 box; other site
639282003498	GTP/Mg2+ binding site [chemical binding]; other site
639282003499	Switch I region; other site
639282003500	G2 box; other site
639282003501	G3 box; other site
639282003502	Switch II region; other site
639282003503	G4 box; other site
639282003504	G5 box; other site
639282003505	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
639282003506	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
639282003507	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
639282003508	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
639282003509	Malic enzyme, N-terminal domain; Region: malic; pfam00390
639282003510	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
639282003511	putative NAD(P) binding site [chemical binding]; other site
639282003512	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
639282003513	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
639282003514	intersubunit interface [polypeptide binding]; other site
639282003515	active site
639282003516	catalytic residue [active]
639282003517	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
639282003518	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
639282003519	active site
639282003520	DNA binding site [nucleotide binding]
639282003521	Int/Topo IB signature motif; other site
639282003522	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
639282003523	DHH family; Region: DHH; pfam01368
639282003524	FOG: CBS domain [General function prediction only]; Region: COG0517
639282003525	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
639282003526	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
639282003527	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
639282003528	active site
639282003529	NTP binding site [chemical binding]; other site
639282003530	metal binding triad [ion binding]; metal-binding site
639282003531	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
639282003532	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
639282003533	PhoH-like protein; Region: PhoH; pfam02562
639282003534	metal-binding heat shock protein; Provisional; Region: PRK00016
639282003535	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
639282003536	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
639282003537	active site
639282003538	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
639282003539	Domain of unknown function DUF21; Region: DUF21; pfam01595
639282003540	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
639282003541	Transporter associated domain; Region: CorC_HlyC; smart01091
639282003542	GTPase Era; Reviewed; Region: era; PRK00089
639282003543	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
639282003544	G1 box; other site
639282003545	GTP/Mg2+ binding site [chemical binding]; other site
639282003546	Switch I region; other site
639282003547	G2 box; other site
639282003548	Switch II region; other site
639282003549	G3 box; other site
639282003550	G4 box; other site
639282003551	G5 box; other site
639282003552	KH domain; Region: KH_2; pfam07650
639282003553	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
639282003554	MgtE intracellular N domain; Region: MgtE_N; pfam03448
639282003555	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
639282003556	Divalent cation transporter; Region: MgtE; pfam01769
639282003557	Recombination protein O N terminal; Region: RecO_N; pfam11967
639282003558	bacterial Hfq-like; Region: Hfq; cd01716
639282003559	hexamer interface [polypeptide binding]; other site
639282003560	Sm1 motif; other site
639282003561	RNA binding site [nucleotide binding]; other site
639282003562	Sm2 motif; other site
639282003563	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
639282003564	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282003565	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282003566	metal binding site [ion binding]; metal-binding site
639282003567	active site
639282003568	I-site; other site
639282003569	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
639282003570	Septum formation initiator; Region: DivIC; pfam04977
639282003571	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
639282003572	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
639282003573	generic binding surface II; other site
639282003574	generic binding surface I; other site
639282003575	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
639282003576	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
639282003577	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
639282003578	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
639282003579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282003580	active site
639282003581	phosphorylation site [posttranslational modification]
639282003582	intermolecular recognition site; other site
639282003583	dimerization interface [polypeptide binding]; other site
639282003584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282003585	Walker A motif; other site
639282003586	ATP binding site [chemical binding]; other site
639282003587	Walker B motif; other site
639282003588	arginine finger; other site
639282003589	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
639282003590	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
639282003591	Uncharacterized conserved protein [Function unknown]; Region: COG2006
639282003592	Domain of unknown function (DUF362); Region: DUF362; pfam04015
639282003593	pyuvate ferredoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09624
639282003594	4Fe-4S binding domain; Region: Fer4; pfam00037
639282003595	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
639282003596	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
639282003597	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
639282003598	catalytic motif [active]
639282003599	Zn binding site [ion binding]; other site
639282003600	RibD C-terminal domain; Region: RibD_C; cl17279
639282003601	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
639282003602	Lumazine binding domain; Region: Lum_binding; pfam00677
639282003603	Lumazine binding domain; Region: Lum_binding; pfam00677
639282003604	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
639282003605	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
639282003606	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
639282003607	dimerization interface [polypeptide binding]; other site
639282003608	active site
639282003609	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
639282003610	homopentamer interface [polypeptide binding]; other site
639282003611	active site
639282003612	transcription antitermination factor NusB; Region: nusB; TIGR01951
639282003613	putative RNA binding site [nucleotide binding]; other site
639282003614	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
639282003615	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
639282003616	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
639282003617	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
639282003618	generic binding surface I; other site
639282003619	generic binding surface II; other site
639282003620	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282003621	Zn2+ binding site [ion binding]; other site
639282003622	Mg2+ binding site [ion binding]; other site
639282003623	uracil-xanthine permease; Region: ncs2; TIGR00801
639282003624	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
639282003625	active site
639282003626	Uncharacterized conserved protein [Function unknown]; Region: COG2928
639282003627	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
639282003628	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
639282003629	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
639282003630	shikimate binding site; other site
639282003631	NAD(P) binding site [chemical binding]; other site
639282003632	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
639282003633	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
639282003634	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
639282003635	Walker A motif; other site
639282003636	ATP binding site [chemical binding]; other site
639282003637	Walker B motif; other site
639282003638	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
639282003639	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
639282003640	Walker A motif; other site
639282003641	ATP binding site [chemical binding]; other site
639282003642	Walker B motif; other site
639282003643	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
639282003644	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
639282003645	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
639282003646	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
639282003647	PAS domain; Region: PAS_10; pfam13596
639282003648	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282003649	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282003650	dimer interface [polypeptide binding]; other site
639282003651	phosphorylation site [posttranslational modification]
639282003652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282003653	ATP binding site [chemical binding]; other site
639282003654	Mg2+ binding site [ion binding]; other site
639282003655	G-X-G motif; other site
639282003656	Transcriptional regulator; Region: Rrf2; cl17282
639282003657	Rrf2 family protein; Region: rrf2_super; TIGR00738
639282003658	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
639282003659	Coenzyme A binding pocket [chemical binding]; other site
639282003660	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
639282003661	peptide chain release factor 2; Validated; Region: prfB; PRK00578
639282003662	PCRF domain; Region: PCRF; pfam03462
639282003663	RF-1 domain; Region: RF-1; pfam00472
639282003664	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
639282003665	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
639282003666	active site
639282003667	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
639282003668	dimer interface [polypeptide binding]; other site
639282003669	substrate binding site [chemical binding]; other site
639282003670	catalytic residues [active]
639282003671	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
639282003672	Permease; Region: Permease; pfam02405
639282003673	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
639282003674	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
639282003675	Walker A/P-loop; other site
639282003676	ATP binding site [chemical binding]; other site
639282003677	Q-loop/lid; other site
639282003678	ABC transporter signature motif; other site
639282003679	Walker B; other site
639282003680	D-loop; other site
639282003681	H-loop/switch region; other site
639282003682	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
639282003683	mce related protein; Region: MCE; pfam02470
639282003684	Ubiquitin-like proteins; Region: UBQ; cl00155
639282003685	charged pocket; other site
639282003686	hydrophobic patch; other site
639282003687	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
639282003688	Phospholipid methyltransferase; Region: PEMT; cl17370
639282003689	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
639282003690	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
639282003691	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
639282003692	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282003693	dimer interface [polypeptide binding]; other site
639282003694	phosphorylation site [posttranslational modification]
639282003695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282003696	ATP binding site [chemical binding]; other site
639282003697	Mg2+ binding site [ion binding]; other site
639282003698	G-X-G motif; other site
639282003699	Response regulator receiver domain; Region: Response_reg; pfam00072
639282003700	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282003701	active site
639282003702	phosphorylation site [posttranslational modification]
639282003703	intermolecular recognition site; other site
639282003704	dimerization interface [polypeptide binding]; other site
639282003705	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
639282003706	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
639282003707	NADP binding site [chemical binding]; other site
639282003708	dimer interface [polypeptide binding]; other site
639282003709	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
639282003710	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
639282003711	putative ligand binding site [chemical binding]; other site
639282003712	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
639282003713	active site
639282003714	substrate binding site [chemical binding]; other site
639282003715	cosubstrate binding site; other site
639282003716	catalytic site [active]
639282003717	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
639282003718	substrate binding site [chemical binding]; other site
639282003719	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
639282003720	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
639282003721	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
639282003722	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
639282003723	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
639282003724	NAD(P) binding site [chemical binding]; other site
639282003725	active site
639282003726	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
639282003727	active site
639282003728	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
639282003729	MoaD interaction [polypeptide binding]; other site
639282003730	active site residues [active]
639282003731	Catalytic domain of Protein Kinases; Region: PKc; cd00180
639282003732	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
639282003733	active site
639282003734	ATP binding site [chemical binding]; other site
639282003735	substrate binding site [chemical binding]; other site
639282003736	activation loop (A-loop); other site
639282003737	Protein of unknown function (DUF342); Region: DUF342; pfam03961
639282003738	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
639282003739	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
639282003740	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
639282003741	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
639282003742	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
639282003743	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
639282003744	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
639282003745	Substrate binding site; other site
639282003746	Cupin domain; Region: Cupin_2; cl17218
639282003747	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
639282003748	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
639282003749	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
639282003750	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
639282003751	active site
639282003752	NAD binding site [chemical binding]; other site
639282003753	metal binding site [ion binding]; metal-binding site
639282003754	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
639282003755	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
639282003756	N-acetyl-D-glucosamine binding site [chemical binding]; other site
639282003757	catalytic residue [active]
639282003758	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
639282003759	FAD binding site [chemical binding]; other site
639282003760	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
639282003761	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282003762	FeS/SAM binding site; other site
639282003763	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
639282003764	Sulfatase; Region: Sulfatase; cl17466
639282003765	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
639282003766	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
639282003767	putative active site [active]
639282003768	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
639282003769	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
639282003770	putative active site [active]
639282003771	DsrE/DsrF-like family; Region: DrsE; cl00672
639282003772	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
639282003773	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
639282003774	Cytochrome c; Region: Cytochrom_C; cl11414
639282003775	SurA N-terminal domain; Region: SurA_N_3; cl07813
639282003776	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
639282003777	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
639282003778	H-type lectin domain; Region: H_lectin; pfam09458
639282003779	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
639282003780	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
639282003781	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282003782	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282003783	metal binding site [ion binding]; metal-binding site
639282003784	active site
639282003785	I-site; other site
639282003786	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
639282003787	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
639282003788	dimer interface [polypeptide binding]; other site
639282003789	putative anticodon binding site; other site
639282003790	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
639282003791	motif 1; other site
639282003792	active site
639282003793	motif 2; other site
639282003794	motif 3; other site
639282003795	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
639282003796	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
639282003797	Ligand Binding Site [chemical binding]; other site
639282003798	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
639282003799	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
639282003800	active site
639282003801	metal binding site [ion binding]; metal-binding site
639282003802	homotetramer interface [polypeptide binding]; other site
639282003803	rod shape-determining protein MreB; Provisional; Region: PRK13927
639282003804	MreB and similar proteins; Region: MreB_like; cd10225
639282003805	nucleotide binding site [chemical binding]; other site
639282003806	Mg binding site [ion binding]; other site
639282003807	putative protofilament interaction site [polypeptide binding]; other site
639282003808	RodZ interaction site [polypeptide binding]; other site
639282003809	rod shape-determining protein MreC; Provisional; Region: PRK13922
639282003810	rod shape-determining protein MreC; Region: MreC; pfam04085
639282003811	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
639282003812	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
639282003813	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
639282003814	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
639282003815	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
639282003816	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282003817	FeS/SAM binding site; other site
639282003818	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
639282003819	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
639282003820	metal binding site 2 [ion binding]; metal-binding site
639282003821	putative DNA binding helix; other site
639282003822	metal binding site 1 [ion binding]; metal-binding site
639282003823	dimer interface [polypeptide binding]; other site
639282003824	structural Zn2+ binding site [ion binding]; other site
639282003825	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
639282003826	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
639282003827	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
639282003828	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
639282003829	catalytic residues [active]
639282003830	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
639282003831	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
639282003832	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
639282003833	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
639282003834	active site
639282003835	dimer interface [polypeptide binding]; other site
639282003836	effector binding site; other site
639282003837	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
639282003838	TSCPD domain; Region: TSCPD; pfam12637
639282003839	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
639282003840	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
639282003841	Cytochrome c; Region: Cytochrom_C; pfam00034
639282003842	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
639282003843	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
639282003844	hexamer interface [polypeptide binding]; other site
639282003845	ligand binding site [chemical binding]; other site
639282003846	putative active site [active]
639282003847	NAD(P) binding site [chemical binding]; other site
639282003848	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
639282003849	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255
639282003850	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
639282003851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282003852	ATP binding site [chemical binding]; other site
639282003853	Mg2+ binding site [ion binding]; other site
639282003854	G-X-G motif; other site
639282003855	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
639282003856	ATP binding site [chemical binding]; other site
639282003857	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
639282003858	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
639282003859	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
639282003860	homoserine dehydrogenase; Provisional; Region: PRK06349
639282003861	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
639282003862	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
639282003863	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
639282003864	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
639282003865	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
639282003866	aspartate kinase; Reviewed; Region: PRK06635
639282003867	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
639282003868	putative nucleotide binding site [chemical binding]; other site
639282003869	putative catalytic residues [active]
639282003870	putative Mg ion binding site [ion binding]; other site
639282003871	putative aspartate binding site [chemical binding]; other site
639282003872	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
639282003873	putative allosteric regulatory site; other site
639282003874	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
639282003875	putative allosteric regulatory residue; other site
639282003876	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
639282003877	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
639282003878	active site
639282003879	catalytic residues [active]
639282003880	metal binding site [ion binding]; metal-binding site
639282003881	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
639282003882	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
639282003883	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
639282003884	transmembrane helices; other site
639282003885	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
639282003886	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
639282003887	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
639282003888	tetramer interface [polypeptide binding]; other site
639282003889	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282003890	catalytic residue [active]
639282003891	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
639282003892	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
639282003893	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
639282003894	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
639282003895	active site
639282003896	HIGH motif; other site
639282003897	nucleotide binding site [chemical binding]; other site
639282003898	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
639282003899	active site
639282003900	KMSKS motif; other site
639282003901	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
639282003902	tRNA binding surface [nucleotide binding]; other site
639282003903	anticodon binding site; other site
639282003904	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
639282003905	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
639282003906	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
639282003907	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
639282003908	purine monophosphate binding site [chemical binding]; other site
639282003909	dimer interface [polypeptide binding]; other site
639282003910	putative catalytic residues [active]
639282003911	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
639282003912	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
639282003913	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
639282003914	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
639282003915	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
639282003916	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
639282003917	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
639282003918	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
639282003919	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
639282003920	IHF - DNA interface [nucleotide binding]; other site
639282003921	IHF dimer interface [polypeptide binding]; other site
639282003922	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
639282003923	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
639282003924	DNA binding residues [nucleotide binding]
639282003925	Probable gene remnant. Similar to the C-terminal region of Salmonella typhimurium Gifsy-2 prophage integrase (430 aa) STM1005.
639282003926	Probable gene remnant. Similar to the C-terminal region of prophage integrase
639282003927	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
639282003928	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
639282003929	P-loop; other site
639282003930	Magnesium ion binding site [ion binding]; other site
639282003931	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
639282003932	Magnesium ion binding site [ion binding]; other site
639282003933	Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077
639282003934	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
639282003935	nucleotide binding site [chemical binding]; other site
639282003936	putative NEF/HSP70 interaction site [polypeptide binding]; other site
639282003937	SBD interface [polypeptide binding]; other site
639282003938	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282003939	dimer interface [polypeptide binding]; other site
639282003940	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
639282003941	putative CheW interface [polypeptide binding]; other site
639282003942	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
639282003943	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282003944	dimer interface [polypeptide binding]; other site
639282003945	putative CheW interface [polypeptide binding]; other site
639282003946	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
639282003947	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
639282003948	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
639282003949	putative CheA interaction surface; other site
639282003950	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
639282003951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282003952	active site
639282003953	phosphorylation site [posttranslational modification]
639282003954	intermolecular recognition site; other site
639282003955	dimerization interface [polypeptide binding]; other site
639282003956	CheB methylesterase; Region: CheB_methylest; pfam01339
639282003957	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
639282003958	anti sigma factor interaction site; other site
639282003959	regulatory phosphorylation site [posttranslational modification]; other site
639282003960	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
639282003961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282003962	active site
639282003963	phosphorylation site [posttranslational modification]
639282003964	intermolecular recognition site; other site
639282003965	dimerization interface [polypeptide binding]; other site
639282003966	HEAT repeats; Region: HEAT_2; pfam13646
639282003967	HEAT repeats; Region: HEAT_2; pfam13646
639282003968	HEAT repeats; Region: HEAT_2; pfam13646
639282003969	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
639282003970	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
639282003971	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
639282003972	Response regulator receiver domain; Region: Response_reg; pfam00072
639282003973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282003974	active site
639282003975	phosphorylation site [posttranslational modification]
639282003976	intermolecular recognition site; other site
639282003977	dimerization interface [polypeptide binding]; other site
639282003978	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
639282003979	putative binding surface; other site
639282003980	active site
639282003981	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
639282003982	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
639282003983	putative binding surface; other site
639282003984	active site
639282003985	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
639282003986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282003987	ATP binding site [chemical binding]; other site
639282003988	Mg2+ binding site [ion binding]; other site
639282003989	G-X-G motif; other site
639282003990	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
639282003991	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
639282003992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
639282003993	active site
639282003994	phosphorylation site [posttranslational modification]
639282003995	intermolecular recognition site; other site
639282003996	dimerization interface [polypeptide binding]; other site
639282003997	GAF domain; Region: GAF_3; pfam13492
639282003998	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
639282003999	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282004000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282004001	dimer interface [polypeptide binding]; other site
639282004002	phosphorylation site [posttranslational modification]
639282004003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282004004	ATP binding site [chemical binding]; other site
639282004005	Mg2+ binding site [ion binding]; other site
639282004006	G-X-G motif; other site
639282004007	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
639282004008	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282004009	active site
639282004010	phosphorylation site [posttranslational modification]
639282004011	intermolecular recognition site; other site
639282004012	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
639282004013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282004014	active site
639282004015	phosphorylation site [posttranslational modification]
639282004016	intermolecular recognition site; other site
639282004017	dimerization interface [polypeptide binding]; other site
639282004018	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
639282004019	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
639282004020	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
639282004021	CheD chemotactic sensory transduction; Region: CheD; cl00810
639282004022	HDOD domain; Region: HDOD; pfam08668
639282004023	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282004024	Zn2+ binding site [ion binding]; other site
639282004025	Mg2+ binding site [ion binding]; other site
639282004026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282004027	Response regulator receiver domain; Region: Response_reg; pfam00072
639282004028	active site
639282004029	phosphorylation site [posttranslational modification]
639282004030	intermolecular recognition site; other site
639282004031	dimerization interface [polypeptide binding]; other site
639282004032	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282004033	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282004034	metal binding site [ion binding]; metal-binding site
639282004035	active site
639282004036	I-site; other site
639282004037	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
639282004038	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
639282004039	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282004040	putative active site [active]
639282004041	heme pocket [chemical binding]; other site
639282004042	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282004043	dimer interface [polypeptide binding]; other site
639282004044	phosphorylation site [posttranslational modification]
639282004045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282004046	ATP binding site [chemical binding]; other site
639282004047	Mg2+ binding site [ion binding]; other site
639282004048	G-X-G motif; other site
639282004049	Response regulator receiver domain; Region: Response_reg; pfam00072
639282004050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282004051	active site
639282004052	phosphorylation site [posttranslational modification]
639282004053	intermolecular recognition site; other site
639282004054	dimerization interface [polypeptide binding]; other site
639282004055	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282004056	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282004057	metal binding site [ion binding]; metal-binding site
639282004058	active site
639282004059	I-site; other site
639282004060	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
639282004061	putative CheA interaction surface; other site
639282004062	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
639282004063	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
639282004064	ATP binding site [chemical binding]; other site
639282004065	putative Mg++ binding site [ion binding]; other site
639282004066	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
639282004067	nucleotide binding region [chemical binding]; other site
639282004068	ATP-binding site [chemical binding]; other site
639282004069	Uncharacterized conserved protein [Function unknown]; Region: COG4715
639282004070	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
639282004071	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
639282004072	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
639282004073	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
639282004074	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
639282004075	ATP-grasp domain; Region: ATP-grasp_4; cl17255
639282004076	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
639282004077	IMP binding site; other site
639282004078	dimer interface [polypeptide binding]; other site
639282004079	interdomain contacts; other site
639282004080	partial ornithine binding site; other site
639282004081	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
639282004082	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
639282004083	FAD binding pocket [chemical binding]; other site
639282004084	FAD binding motif [chemical binding]; other site
639282004085	phosphate binding motif [ion binding]; other site
639282004086	beta-alpha-beta structure motif; other site
639282004087	NAD binding pocket [chemical binding]; other site
639282004088	Iron coordination center [ion binding]; other site
639282004089	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
639282004090	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
639282004091	heterodimer interface [polypeptide binding]; other site
639282004092	active site
639282004093	FMN binding site [chemical binding]; other site
639282004094	homodimer interface [polypeptide binding]; other site
639282004095	substrate binding site [chemical binding]; other site
639282004096	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
639282004097	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
639282004098	active site
639282004099	motif I; other site
639282004100	motif II; other site
639282004101	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
639282004102	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
639282004103	active site
639282004104	putative substrate binding pocket [chemical binding]; other site
639282004105	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
639282004106	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
639282004107	tetramer interface [polypeptide binding]; other site
639282004108	active site
639282004109	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
639282004110	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
639282004111	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
639282004112	carboxyltransferase (CT) interaction site; other site
639282004113	biotinylation site [posttranslational modification]; other site
639282004114	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
639282004115	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
639282004116	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
639282004117	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
639282004118	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
639282004119	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
639282004120	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
639282004121	futalosine nucleosidase; Region: fut_nucase; TIGR03664
639282004122	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
639282004123	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
639282004124	N- and C-terminal domain interface [polypeptide binding]; other site
639282004125	active site
639282004126	MgATP binding site [chemical binding]; other site
639282004127	catalytic site [active]
639282004128	metal binding site [ion binding]; metal-binding site
639282004129	glycerol binding site [chemical binding]; other site
639282004130	homotetramer interface [polypeptide binding]; other site
639282004131	homodimer interface [polypeptide binding]; other site
639282004132	FBP binding site [chemical binding]; other site
639282004133	protein IIAGlc interface [polypeptide binding]; other site
639282004134	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
639282004135	active site 2 [active]
639282004136	active site 1 [active]
639282004137	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
639282004138	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
639282004139	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
639282004140	hypothetical protein; Reviewed; Region: PRK09588
639282004141	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282004142	dimer interface [polypeptide binding]; other site
639282004143	conserved gate region; other site
639282004144	putative PBP binding loops; other site
639282004145	ABC-ATPase subunit interface; other site
639282004146	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
639282004147	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
639282004148	substrate binding pocket [chemical binding]; other site
639282004149	membrane-bound complex binding site; other site
639282004150	hinge residues; other site
639282004151	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282004152	dimer interface [polypeptide binding]; other site
639282004153	conserved gate region; other site
639282004154	putative PBP binding loops; other site
639282004155	ABC-ATPase subunit interface; other site
639282004156	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
639282004157	Cupin domain; Region: Cupin_2; pfam07883
639282004158	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
639282004159	butyrate kinase; Provisional; Region: PRK03011
639282004160	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
639282004161	putative active site [active]
639282004162	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
639282004163	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
639282004164	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
639282004165	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
639282004166	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282004167	Walker A motif; other site
639282004168	ATP binding site [chemical binding]; other site
639282004169	Walker B motif; other site
639282004170	arginine finger; other site
639282004171	Bacterial SH3 domain; Region: SH3_3; pfam08239
639282004172	type II restriction endonuclease, Alw26I/Eco31I/Esp3I family; Region: restrict_Alw26I; TIGR02986
639282004173	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
639282004174	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
639282004175	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
639282004176	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
639282004177	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
639282004178	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
639282004179	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
639282004180	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
639282004181	Walker A motif; other site
639282004182	ATP binding site [chemical binding]; other site
639282004183	Walker B motif; other site
639282004184	BioY family; Region: BioY; pfam02632
639282004185	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
639282004186	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
639282004187	nucleophile elbow; other site
639282004188	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
639282004189	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
639282004190	catalytic loop [active]
639282004191	iron binding site [ion binding]; other site
639282004192	4Fe-4S binding domain; Region: Fer4; pfam00037
639282004193	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
639282004194	[4Fe-4S] binding site [ion binding]; other site
639282004195	molybdopterin cofactor binding site; other site
639282004196	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
639282004197	molybdopterin cofactor binding site; other site
639282004198	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
639282004199	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
639282004200	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
639282004201	Uncharacterized conserved protein [Function unknown]; Region: COG1565
639282004202	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
639282004203	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
639282004204	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
639282004205	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
639282004206	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
639282004207	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
639282004208	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
639282004209	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
639282004210	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
639282004211	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
639282004212	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
639282004213	Walker A/P-loop; other site
639282004214	ATP binding site [chemical binding]; other site
639282004215	Q-loop/lid; other site
639282004216	ABC transporter signature motif; other site
639282004217	Walker B; other site
639282004218	D-loop; other site
639282004219	H-loop/switch region; other site
639282004220	pyruvate carboxylase; Reviewed; Region: PRK12999
639282004221	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
639282004222	ATP-grasp domain; Region: ATP-grasp_4; cl17255
639282004223	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
639282004224	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
639282004225	active site
639282004226	catalytic residues [active]
639282004227	metal binding site [ion binding]; metal-binding site
639282004228	homodimer binding site [polypeptide binding]; other site
639282004229	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
639282004230	carboxyltransferase (CT) interaction site; other site
639282004231	biotinylation site [posttranslational modification]; other site
639282004232	mechanosensitive channel MscS; Provisional; Region: PRK10334
639282004233	Mechanosensitive ion channel; Region: MS_channel; pfam00924
639282004234	Stringent starvation protein B; Region: SspB; cl01120
639282004235	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
639282004236	Mechanosensitive ion channel; Region: MS_channel; pfam00924
639282004237	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
639282004238	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
639282004239	Domain of unknown function DUF; Region: DUF204; pfam02659
639282004240	Domain of unknown function DUF; Region: DUF204; pfam02659
639282004241	Predicted permease [General function prediction only]; Region: COG2985
639282004242	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
639282004243	TrkA-C domain; Region: TrkA_C; pfam02080
639282004244	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
639282004245	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
639282004246	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
639282004247	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
639282004248	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
639282004249	pyrroline-5-carboxylate reductase; Region: PLN02688
639282004250	Esterase/lipase [General function prediction only]; Region: COG1647
639282004251	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
639282004252	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
639282004253	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
639282004254	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
639282004255	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
639282004256	dimer interface [polypeptide binding]; other site
639282004257	active site
639282004258	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
639282004259	catalytic residues [active]
639282004260	substrate binding site [chemical binding]; other site
639282004261	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
639282004262	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
639282004263	arginine decarboxylase; Provisional; Region: PRK05354
639282004264	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
639282004265	dimer interface [polypeptide binding]; other site
639282004266	active site
639282004267	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
639282004268	catalytic residues [active]
639282004269	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
639282004270	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
639282004271	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
639282004272	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
639282004273	acyl-activating enzyme (AAE) consensus motif; other site
639282004274	AMP binding site [chemical binding]; other site
639282004275	active site
639282004276	CoA binding site [chemical binding]; other site
639282004277	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
639282004278	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
639282004279	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
639282004280	dimer interface [polypeptide binding]; other site
639282004281	PYR/PP interface [polypeptide binding]; other site
639282004282	TPP binding site [chemical binding]; other site
639282004283	substrate binding site [chemical binding]; other site
639282004284	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
639282004285	TPP-binding site; other site
639282004286	4Fe-4S binding domain; Region: Fer4; pfam00037
639282004287	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
639282004288	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
639282004289	substrate binding pocket [chemical binding]; other site
639282004290	membrane-bound complex binding site; other site
639282004291	hinge residues; other site
639282004292	PAS fold; Region: PAS_4; pfam08448
639282004293	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
639282004294	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
639282004295	putative active site [active]
639282004296	heme pocket [chemical binding]; other site
639282004297	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282004298	dimer interface [polypeptide binding]; other site
639282004299	phosphorylation site [posttranslational modification]
639282004300	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282004301	ATP binding site [chemical binding]; other site
639282004302	Mg2+ binding site [ion binding]; other site
639282004303	G-X-G motif; other site
639282004304	Response regulator receiver domain; Region: Response_reg; pfam00072
639282004305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282004306	active site
639282004307	phosphorylation site [posttranslational modification]
639282004308	intermolecular recognition site; other site
639282004309	dimerization interface [polypeptide binding]; other site
639282004310	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
639282004311	FMN binding site [chemical binding]; other site
639282004312	dimer interface [polypeptide binding]; other site
639282004313	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
639282004314	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
639282004315	catalytic residues [active]
639282004316	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
639282004317	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
639282004318	AAA domain; Region: AAA_26; pfam13500
639282004319	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
639282004320	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
639282004321	inhibitor-cofactor binding pocket; inhibition site
639282004322	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282004323	catalytic residue [active]
639282004324	biotin synthase; Region: bioB; TIGR00433
639282004325	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282004326	FeS/SAM binding site; other site
639282004327	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
639282004328	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
639282004329	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
639282004330	substrate-cofactor binding pocket; other site
639282004331	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282004332	catalytic residue [active]
639282004333	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
639282004334	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
639282004335	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282004336	S-adenosylmethionine binding site [chemical binding]; other site
639282004337	para-aminobenzoate synthase component I; Validated; Region: PRK07093
639282004338	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
639282004339	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
639282004340	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
639282004341	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
639282004342	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
639282004343	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
639282004344	Walker A motif; other site
639282004345	ATP binding site [chemical binding]; other site
639282004346	Walker B motif; other site
639282004347	type II secretion system protein D; Region: type_II_gspD; TIGR02517
639282004348	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
639282004349	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
639282004350	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
639282004351	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
639282004352	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
639282004353	CAAX protease self-immunity; Region: Abi; pfam02517
639282004354	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
639282004355	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
639282004356	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
639282004357	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
639282004358	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
639282004359	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
639282004360	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
639282004361	classical (c) SDRs; Region: SDR_c; cd05233
639282004362	NAD(P) binding site [chemical binding]; other site
639282004363	active site
639282004364	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
639282004365	Pseudogene. Similar to conserved hypothetical protein. This CDS appears to have a frameshift mutation
639282004366	Probable gene remnant. Similar to the C-terminal region of Methanosarcina mazei conserved hypothetical protein (107 aa) MM_3292.
639282004367	Probable gene remnant. Similar to the N-terminal region of Methanosarcina mazei conserved hypothetical protein (107 aa) MM_3292.
639282004368	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
639282004369	active site 1 [active]
639282004370	dimer interface [polypeptide binding]; other site
639282004371	hexamer interface [polypeptide binding]; other site
639282004372	active site 2 [active]
639282004373	Pseudogene. Similar to bile acid:sodium symporter. This CDS is disrupted by the insertion of IS element.
639282004374	Probable gene remnant. Similar to the N-terminal region of Desulfotomaculum reducens MI-1 bile acid:sodium symporter (350 aa) Dred_0554.
639282004375	Transposase, Mutator family; Region: Transposase_mut; pfam00872
639282004376	MULE transposase domain; Region: MULE; pfam10551
639282004377	Probable gene remnant. Similar to the C-terminal region of Desulfotomaculum reducens MI-1 bile acid:sodium symporter (350 aa) Dred_0554.
639282004378	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
639282004379	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
639282004380	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
639282004381	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
639282004382	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
639282004383	[4Fe-4S] binding site [ion binding]; other site
639282004384	molybdopterin cofactor binding site; other site
639282004385	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
639282004386	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
639282004387	molybdopterin cofactor binding site; other site
639282004388	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
639282004389	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
639282004390	Ferredoxin [Energy production and conversion]; Region: COG1146
639282004391	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
639282004392	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
639282004393	4Fe-4S binding domain; Region: Fer4; pfam00037
639282004394	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
639282004395	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
639282004396	CHASE2 domain; Region: CHASE2; pfam05226
639282004397	NADH dehydrogenase; Region: NADHdh; cl00469
639282004398	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
639282004399	cyclase homology domain; Region: CHD; cd07302
639282004400	nucleotidyl binding site; other site
639282004401	metal binding site [ion binding]; metal-binding site
639282004402	dimer interface [polypeptide binding]; other site
639282004403	FecR protein; Region: FecR; pfam04773
639282004404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
639282004405	binding surface
639282004406	TPR motif; other site
639282004407	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
639282004408	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
639282004409	nucleotide binding site [chemical binding]; other site
639282004410	Radical SAM superfamily; Region: Radical_SAM; pfam04055
639282004411	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
639282004412	hydrolase; Region: PLN02511
639282004413	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
639282004414	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
639282004415	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
639282004416	P loop; other site
639282004417	GTP binding site [chemical binding]; other site
639282004418	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
639282004419	AAA domain; Region: AAA_23; pfam13476
639282004420	Walker A/P-loop; other site
639282004421	ATP binding site [chemical binding]; other site
639282004422	Q-loop/lid; other site
639282004423	Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340
639282004424	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
639282004425	Q-loop/lid; other site
639282004426	ABC transporter signature motif; other site
639282004427	Walker B; other site
639282004428	D-loop; other site
639282004429	H-loop/switch region; other site
639282004430	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
639282004431	Transcriptional regulators [Transcription]; Region: FadR; COG2186
639282004432	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
639282004433	DNA-binding site [nucleotide binding]; DNA binding site
639282004434	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
639282004435	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
639282004436	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
639282004437	Cysteine-rich domain; Region: CCG; pfam02754
639282004438	Cysteine-rich domain; Region: CCG; pfam02754
639282004439	FAD binding domain; Region: FAD_binding_4; pfam01565
639282004440	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
639282004441	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
639282004442	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
639282004443	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
639282004444	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
639282004445	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
639282004446	Cysteine-rich domain; Region: CCG; pfam02754
639282004447	Cysteine-rich domain; Region: CCG; pfam02754
639282004448	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
639282004449	dimer interface [polypeptide binding]; other site
639282004450	catalytic triad [active]
639282004451	peroxidatic and resolving cysteines [active]
639282004452	transcriptional activator RfaH; Region: RfaH; TIGR01955
639282004453	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
639282004454	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
639282004455	heterodimer interface [polypeptide binding]; other site
639282004456	homodimer interface [polypeptide binding]; other site
639282004457	Protein of unknown function (DUF1634); Region: DUF1634; cl01741
639282004458	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
639282004459	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
639282004460	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
639282004461	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
639282004462	domain interfaces; other site
639282004463	active site
639282004464	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
639282004465	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
639282004466	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
639282004467	Sporulation related domain; Region: SPOR; pfam05036
639282004468	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
639282004469	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
639282004470	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
639282004471	active site
639282004472	HIGH motif; other site
639282004473	KMSK motif region; other site
639282004474	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
639282004475	tRNA binding surface [nucleotide binding]; other site
639282004476	anticodon binding site; other site
639282004477	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
639282004478	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
639282004479	RNA polymerase Rpc34 subunit; Region: RNA_pol_Rpc34; cl02127
639282004480	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
639282004481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282004482	Walker A/P-loop; other site
639282004483	ATP binding site [chemical binding]; other site
639282004484	Q-loop/lid; other site
639282004485	ABC transporter signature motif; other site
639282004486	Walker B; other site
639282004487	D-loop; other site
639282004488	H-loop/switch region; other site
639282004489	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
639282004490	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
639282004491	Peptidase family M23; Region: Peptidase_M23; pfam01551
639282004492	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
639282004493	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
639282004494	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
639282004495	protein binding site [polypeptide binding]; other site
639282004496	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
639282004497	Catalytic dyad [active]
639282004498	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
639282004499	NodB motif; other site
639282004500	putative active site [active]
639282004501	putative catalytic site [active]
639282004502	Zn binding site [ion binding]; other site
639282004503	UGMP family protein; Validated; Region: PRK09604
639282004504	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
639282004505	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
639282004506	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
639282004507	FMN binding site [chemical binding]; other site
639282004508	active site
639282004509	catalytic residues [active]
639282004510	substrate binding site [chemical binding]; other site
639282004511	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
639282004512	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
639282004513	motif II; other site
639282004514	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
639282004515	nucleoside/Zn binding site; other site
639282004516	dimer interface [polypeptide binding]; other site
639282004517	catalytic motif [active]
639282004518	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
639282004519	RNA methyltransferase, RsmE family; Region: TIGR00046
639282004520	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
639282004521	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
639282004522	active site
639282004523	metal binding site [ion binding]; metal-binding site
639282004524	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
639282004525	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
639282004526	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
639282004527	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
639282004528	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282004529	active site
639282004530	phosphorylation site [posttranslational modification]
639282004531	intermolecular recognition site; other site
639282004532	dimerization interface [polypeptide binding]; other site
639282004533	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282004534	Walker A motif; other site
639282004535	ATP binding site [chemical binding]; other site
639282004536	Walker B motif; other site
639282004537	arginine finger; other site
639282004538	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
639282004539	PAS fold; Region: PAS_4; pfam08448
639282004540	PAS domain; Region: PAS_8; pfam13188
639282004541	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
639282004542	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282004543	phosphorylation site [posttranslational modification]
639282004544	dimer interface [polypeptide binding]; other site
639282004545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282004546	ATP binding site [chemical binding]; other site
639282004547	Mg2+ binding site [ion binding]; other site
639282004548	G-X-G motif; other site
639282004549	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
639282004550	Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357
639282004551	Oligomerisation domain; Region: Oligomerisation; pfam02410
639282004552	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
639282004553	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
639282004554	active site
639282004555	(T/H)XGH motif; other site
639282004556	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
639282004557	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
639282004558	putative catalytic cysteine [active]
639282004559	gamma-glutamyl kinase; Provisional; Region: PRK05429
639282004560	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
639282004561	nucleotide binding site [chemical binding]; other site
639282004562	homotetrameric interface [polypeptide binding]; other site
639282004563	putative phosphate binding site [ion binding]; other site
639282004564	putative allosteric binding site; other site
639282004565	PUA domain; Region: PUA; pfam01472
639282004566	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
639282004567	Response regulator receiver domain; Region: Response_reg; pfam00072
639282004568	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282004569	active site
639282004570	phosphorylation site [posttranslational modification]
639282004571	intermolecular recognition site; other site
639282004572	dimerization interface [polypeptide binding]; other site
639282004573	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282004574	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282004575	dimer interface [polypeptide binding]; other site
639282004576	phosphorylation site [posttranslational modification]
639282004577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282004578	ATP binding site [chemical binding]; other site
639282004579	G-X-G motif; other site
639282004580	Major Facilitator Superfamily; Region: MFS_1; pfam07690
639282004581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
639282004582	putative substrate translocation pore; other site
639282004583	Uncharacterized conserved protein [Function unknown]; Region: COG4717
639282004584	AAA domain; Region: AAA_27; pfam13514
639282004585	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
639282004586	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
639282004587	active site
639282004588	metal binding site [ion binding]; metal-binding site
639282004589	DNA binding site [nucleotide binding]
639282004590	Bifunctional nuclease; Region: DNase-RNase; pfam02577
639282004591	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
639282004592	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
639282004593	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282004594	FeS/SAM binding site; other site
639282004595	TRAM domain; Region: TRAM; pfam01938
639282004596	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
639282004597	FAD binding domain; Region: FAD_binding_4; pfam01565
639282004598	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
639282004599	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
639282004600	Cysteine-rich domain; Region: CCG; pfam02754
639282004601	Cysteine-rich domain; Region: CCG; pfam02754
639282004602	Membrane transport protein; Region: Mem_trans; cl09117
639282004603	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
639282004604	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
639282004605	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282004606	catalytic residue [active]
639282004607	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
639282004608	Predicted amidohydrolase [General function prediction only]; Region: COG0388
639282004609	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
639282004610	active site
639282004611	catalytic triad [active]
639282004612	dimer interface [polypeptide binding]; other site
639282004613	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
639282004614	DctM-like transporters; Region: DctM; pfam06808
639282004615	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
639282004616	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
639282004617	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
639282004618	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
639282004619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282004620	active site
639282004621	phosphorylation site [posttranslational modification]
639282004622	intermolecular recognition site; other site
639282004623	dimerization interface [polypeptide binding]; other site
639282004624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282004625	Walker A motif; other site
639282004626	ATP binding site [chemical binding]; other site
639282004627	Walker B motif; other site
639282004628	arginine finger; other site
639282004629	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
639282004630	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282004631	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282004632	dimerization interface [polypeptide binding]; other site
639282004633	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282004634	phosphorylation site [posttranslational modification]
639282004635	dimer interface [polypeptide binding]; other site
639282004636	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282004637	ATP binding site [chemical binding]; other site
639282004638	G-X-G motif; other site
639282004639	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
639282004640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
639282004641	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
639282004642	AAA domain; Region: AAA_33; pfam13671
639282004643	active site
639282004644	Isochorismatase family; Region: Isochorismatase; pfam00857
639282004645	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
639282004646	catalytic triad [active]
639282004647	conserved cis-peptide bond; other site
639282004648	endonuclease IV; Provisional; Region: PRK01060
639282004649	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
639282004650	AP (apurinic/apyrimidinic) site pocket; other site
639282004651	DNA interaction; other site
639282004652	Metal-binding active site; metal-binding site
639282004653	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
639282004654	AMP binding site [chemical binding]; other site
639282004655	metal binding site [ion binding]; metal-binding site
639282004656	active site
639282004657	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282004658	binding surface
639282004659	Tetratricopeptide repeat; Region: TPR_16; pfam13432
639282004660	TPR motif; other site
639282004661	Tetratricopeptide repeat; Region: TPR_16; pfam13432
639282004662	Stage II sporulation protein; Region: SpoIID; pfam08486
639282004663	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
639282004664	LPP20 lipoprotein; Region: LPP20; pfam02169
639282004665	S-layer homology domain; Region: SLH; pfam00395
639282004666	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
639282004667	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
639282004668	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
639282004669	Cupin domain; Region: Cupin_2; pfam07883
639282004670	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
639282004671	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282004672	S-adenosylmethionine binding site [chemical binding]; other site
639282004673	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
639282004674	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
639282004675	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
639282004676	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
639282004677	putative active site [active]
639282004678	dimerization interface [polypeptide binding]; other site
639282004679	putative tRNAtyr binding site [nucleotide binding]; other site
639282004680	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
639282004681	MviN-like protein; Region: MVIN; pfam03023
639282004682	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
639282004683	IHF - DNA interface [nucleotide binding]; other site
639282004684	IHF dimer interface [polypeptide binding]; other site
639282004685	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
639282004686	Fe-S cluster binding site [ion binding]; other site
639282004687	active site
639282004688	Flavoprotein; Region: Flavoprotein; pfam02441
639282004689	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
639282004690	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
639282004691	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
639282004692	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
639282004693	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
639282004694	catalytic site [active]
639282004695	G-X2-G-X-G-K; other site
639282004696	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
639282004697	NAD(P) binding site [chemical binding]; other site
639282004698	hypothetical protein; Provisional; Region: PRK11820
639282004699	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
639282004700	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
639282004701	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
639282004702	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
639282004703	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
639282004704	Ligand Binding Site [chemical binding]; other site
639282004705	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
639282004706	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
639282004707	DNA-binding site [nucleotide binding]; DNA binding site
639282004708	RNA-binding motif; other site
639282004709	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
639282004710	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
639282004711	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
639282004712	putative dimerization interface [polypeptide binding]; other site
639282004713	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
639282004714	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
639282004715	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
639282004716	conserved cys residue [active]
639282004717	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
639282004718	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
639282004719	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
639282004720	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
639282004721	Flavin Reductases; Region: FlaRed; cl00801
639282004722	Ion transport protein; Region: Ion_trans; pfam00520
639282004723	Ion channel; Region: Ion_trans_2; pfam07885
639282004724	Double zinc ribbon; Region: DZR; pfam12773
639282004725	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
639282004726	FOG: CBS domain [General function prediction only]; Region: COG0517
639282004727	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
639282004728	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
639282004729	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
639282004730	active site residue [active]
639282004731	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
639282004732	active site residue [active]
639282004733	tetrathionate reductase subunit A; Provisional; Region: PRK14991
639282004734	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
639282004735	putative [Fe4-S4] binding site [ion binding]; other site
639282004736	putative molybdopterin cofactor binding site [chemical binding]; other site
639282004737	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
639282004738	putative molybdopterin cofactor binding site; other site
639282004739	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
639282004740	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
639282004741	Protein export membrane protein; Region: SecD_SecF; cl14618
639282004742	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
639282004743	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
639282004744	HlyD family secretion protein; Region: HlyD_3; pfam13437
639282004745	Outer membrane efflux protein; Region: OEP; pfam02321
639282004746	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
639282004747	dimerization interface [polypeptide binding]; other site
639282004748	putative DNA binding site [nucleotide binding]; other site
639282004749	putative Zn2+ binding site [ion binding]; other site
639282004750	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
639282004751	Low molecular weight phosphatase family; Region: LMWPc; cd00115
639282004752	active site
639282004753	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
639282004754	arsenical-resistance protein; Region: acr3; TIGR00832
639282004755	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
639282004756	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282004757	active site
639282004758	phosphorylation site [posttranslational modification]
639282004759	intermolecular recognition site; other site
639282004760	dimerization interface [polypeptide binding]; other site
639282004761	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282004762	Walker A motif; other site
639282004763	ATP binding site [chemical binding]; other site
639282004764	Walker B motif; other site
639282004765	arginine finger; other site
639282004766	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
639282004767	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282004768	dimer interface [polypeptide binding]; other site
639282004769	phosphorylation site [posttranslational modification]
639282004770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282004771	ATP binding site [chemical binding]; other site
639282004772	Mg2+ binding site [ion binding]; other site
639282004773	G-X-G motif; other site
639282004774	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
639282004775	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
639282004776	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
639282004777	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282004778	FeS/SAM binding site; other site
639282004779	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
639282004780	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
639282004781	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
639282004782	Ligand Binding Site [chemical binding]; other site
639282004783	Archease protein family (MTH1598/TM1083); Region: Archease; cl00606
639282004784	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
639282004785	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
639282004786	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
639282004787	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
639282004788	active site
639282004789	substrate-binding site [chemical binding]; other site
639282004790	metal-binding site [ion binding]
639282004791	ATP binding site [chemical binding]; other site
639282004792	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
639282004793	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
639282004794	active site
639282004795	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
639282004796	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
639282004797	motif 1; other site
639282004798	active site
639282004799	motif 2; other site
639282004800	motif 3; other site
639282004801	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
639282004802	DHHA1 domain; Region: DHHA1; pfam02272
639282004803	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
639282004804	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
639282004805	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
639282004806	active site
639282004807	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
639282004808	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
639282004809	dimer interface [polypeptide binding]; other site
639282004810	active site
639282004811	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
639282004812	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
639282004813	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
639282004814	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
639282004815	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
639282004816	substrate binding site [chemical binding]; other site
639282004817	oxyanion hole (OAH) forming residues; other site
639282004818	trimer interface [polypeptide binding]; other site
639282004819	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
639282004820	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
639282004821	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
639282004822	acyl-activating enzyme (AAE) consensus motif; other site
639282004823	putative AMP binding site [chemical binding]; other site
639282004824	putative active site [active]
639282004825	putative CoA binding site [chemical binding]; other site
639282004826	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
639282004827	Bacterial Ig-like domain; Region: Big_5; pfam13205
639282004828	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
639282004829	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
639282004830	active site
639282004831	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
639282004832	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
639282004833	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
639282004834	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282004835	S-adenosylmethionine binding site [chemical binding]; other site
639282004836	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
639282004837	glutamine synthetase, type I; Region: GlnA; TIGR00653
639282004838	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
639282004839	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
639282004840	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
639282004841	Nitrogen regulatory protein P-II; Region: P-II; smart00938
639282004842	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
639282004843	mce related protein; Region: MCE; pfam02470
639282004844	Permease; Region: Permease; pfam02405
639282004845	Tetratricopeptide repeat; Region: TPR_16; pfam13432
639282004846	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282004847	TPR motif; other site
639282004848	binding surface
639282004849	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282004850	binding surface
639282004851	TPR motif; other site
639282004852	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
639282004853	RNA/DNA hybrid binding site [nucleotide binding]; other site
639282004854	active site
639282004855	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
639282004856	Putative zinc ribbon domain; Region: DUF164; pfam02591
639282004857	Uncharacterized conserved protein [Function unknown]; Region: COG0327
639282004858	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
639282004859	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
639282004860	Uncharacterized conserved protein [Function unknown]; Region: COG0327
639282004861	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
639282004862	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
639282004863	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
639282004864	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
639282004865	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
639282004866	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
639282004867	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
639282004868	DNA binding residues [nucleotide binding]
639282004869	DNA primase; Validated; Region: dnaG; PRK05667
639282004870	CHC2 zinc finger; Region: zf-CHC2; pfam01807
639282004871	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
639282004872	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
639282004873	active site
639282004874	metal binding site [ion binding]; metal-binding site
639282004875	interdomain interaction site; other site
639282004876	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
639282004877	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
639282004878	Walker A/P-loop; other site
639282004879	ATP binding site [chemical binding]; other site
639282004880	Q-loop/lid; other site
639282004881	ABC transporter signature motif; other site
639282004882	Walker B; other site
639282004883	D-loop; other site
639282004884	H-loop/switch region; other site
639282004885	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
639282004886	FOG: CBS domain [General function prediction only]; Region: COG0517
639282004887	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
639282004888	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
639282004889	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
639282004890	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
639282004891	active site
639282004892	CoA binding site [chemical binding]; other site
639282004893	AMP binding site [chemical binding]; other site
639282004894	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
639282004895	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
639282004896	Walker A/P-loop; other site
639282004897	ATP binding site [chemical binding]; other site
639282004898	Q-loop/lid; other site
639282004899	ABC transporter signature motif; other site
639282004900	Walker B; other site
639282004901	D-loop; other site
639282004902	H-loop/switch region; other site
639282004903	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
639282004904	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
639282004905	putative ligand binding site [chemical binding]; other site
639282004906	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
639282004907	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
639282004908	TM-ABC transporter signature motif; other site
639282004909	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
639282004910	TM-ABC transporter signature motif; other site
639282004911	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
639282004912	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
639282004913	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
639282004914	acyl-activating enzyme (AAE) consensus motif; other site
639282004915	putative AMP binding site [chemical binding]; other site
639282004916	putative active site [active]
639282004917	putative CoA binding site [chemical binding]; other site
639282004918	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
639282004919	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
639282004920	Walker A/P-loop; other site
639282004921	ATP binding site [chemical binding]; other site
639282004922	Q-loop/lid; other site
639282004923	ABC transporter signature motif; other site
639282004924	Walker B; other site
639282004925	D-loop; other site
639282004926	H-loop/switch region; other site
639282004927	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
639282004928	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
639282004929	HSP70 interaction site [polypeptide binding]; other site
639282004930	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
639282004931	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
639282004932	active site
639282004933	dimerization interface [polypeptide binding]; other site
639282004934	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
639282004935	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
639282004936	23S rRNA binding site [nucleotide binding]; other site
639282004937	L21 binding site [polypeptide binding]; other site
639282004938	L13 binding site [polypeptide binding]; other site
639282004939	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
639282004940	translation initiation factor IF-3; Region: infC; TIGR00168
639282004941	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
639282004942	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
639282004943	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
639282004944	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
639282004945	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
639282004946	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
639282004947	active site
639282004948	dimer interface [polypeptide binding]; other site
639282004949	motif 1; other site
639282004950	motif 2; other site
639282004951	motif 3; other site
639282004952	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
639282004953	anticodon binding site; other site
639282004954	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
639282004955	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
639282004956	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282004957	Walker A/P-loop; other site
639282004958	ATP binding site [chemical binding]; other site
639282004959	Q-loop/lid; other site
639282004960	ABC transporter signature motif; other site
639282004961	Walker B; other site
639282004962	D-loop; other site
639282004963	H-loop/switch region; other site
639282004964	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
639282004965	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
639282004966	TM-ABC transporter signature motif; other site
639282004967	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
639282004968	zinc binding site [ion binding]; other site
639282004969	putative ligand binding site [chemical binding]; other site
639282004970	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
639282004971	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
639282004972	catalytic center binding site [active]
639282004973	ATP binding site [chemical binding]; other site
639282004974	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
639282004975	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
639282004976	putative acyl-acceptor binding pocket; other site
639282004977	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
639282004978	Predicted oxidoreductase [General function prediction only]; Region: COG3573
639282004979	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
639282004980	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
639282004981	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
639282004982	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
639282004983	homotetramer interface [polypeptide binding]; other site
639282004984	ligand binding site [chemical binding]; other site
639282004985	catalytic site [active]
639282004986	NAD binding site [chemical binding]; other site
639282004987	S-adenosylmethionine synthetase; Validated; Region: PRK05250
639282004988	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
639282004989	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
639282004990	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
639282004991	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
639282004992	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
639282004993	Coenzyme A binding pocket [chemical binding]; other site
639282004994	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
639282004995	Glycoprotease family; Region: Peptidase_M22; pfam00814
639282004996	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
639282004997	trimer interface [polypeptide binding]; other site
639282004998	active site
639282004999	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
639282005000	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
639282005001	RNase E interface [polypeptide binding]; other site
639282005002	trimer interface [polypeptide binding]; other site
639282005003	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
639282005004	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
639282005005	RNase E interface [polypeptide binding]; other site
639282005006	trimer interface [polypeptide binding]; other site
639282005007	active site
639282005008	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
639282005009	putative nucleic acid binding region [nucleotide binding]; other site
639282005010	G-X-X-G motif; other site
639282005011	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
639282005012	RNA binding site [nucleotide binding]; other site
639282005013	domain interface; other site
639282005014	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
639282005015	16S/18S rRNA binding site [nucleotide binding]; other site
639282005016	S13e-L30e interaction site [polypeptide binding]; other site
639282005017	25S rRNA binding site [nucleotide binding]; other site
639282005018	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
639282005019	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
639282005020	RNA binding site [nucleotide binding]; other site
639282005021	active site
639282005022	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
639282005023	Protein of unknown function (DUF503); Region: DUF503; pfam04456
639282005024	translation initiation factor IF-2; Region: IF-2; TIGR00487
639282005025	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
639282005026	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
639282005027	G1 box; other site
639282005028	putative GEF interaction site [polypeptide binding]; other site
639282005029	GTP/Mg2+ binding site [chemical binding]; other site
639282005030	Switch I region; other site
639282005031	G2 box; other site
639282005032	G3 box; other site
639282005033	Switch II region; other site
639282005034	G4 box; other site
639282005035	G5 box; other site
639282005036	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
639282005037	Translation-initiation factor 2; Region: IF-2; pfam11987
639282005038	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
639282005039	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
639282005040	putative RNA binding cleft [nucleotide binding]; other site
639282005041	NusA N-terminal domain; Region: NusA_N; pfam08529
639282005042	transcription termination factor NusA; Region: NusA; TIGR01953
639282005043	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
639282005044	RNA binding site [nucleotide binding]; other site
639282005045	homodimer interface [polypeptide binding]; other site
639282005046	NusA-like KH domain; Region: KH_5; pfam13184
639282005047	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
639282005048	G-X-X-G motif; other site
639282005049	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
639282005050	ribosome maturation protein RimP; Reviewed; Region: PRK00092
639282005051	Sm and related proteins; Region: Sm_like; cl00259
639282005052	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
639282005053	putative oligomer interface [polypeptide binding]; other site
639282005054	putative RNA binding site [nucleotide binding]; other site
639282005055	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
639282005056	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
639282005057	trimer interface [polypeptide binding]; other site
639282005058	putative metal binding site [ion binding]; other site
639282005059	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282005060	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282005061	dimer interface [polypeptide binding]; other site
639282005062	phosphorylation site [posttranslational modification]
639282005063	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
639282005064	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
639282005065	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
639282005066	non-specific DNA binding site [nucleotide binding]; other site
639282005067	salt bridge; other site
639282005068	sequence-specific DNA binding site [nucleotide binding]; other site
639282005069	Cupin domain; Region: Cupin_2; pfam07883
639282005070	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
639282005071	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
639282005072	elongation factor G; Reviewed; Region: PRK12740
639282005073	G1 box; other site
639282005074	putative GEF interaction site [polypeptide binding]; other site
639282005075	GTP/Mg2+ binding site [chemical binding]; other site
639282005076	Switch I region; other site
639282005077	G2 box; other site
639282005078	G3 box; other site
639282005079	Switch II region; other site
639282005080	G4 box; other site
639282005081	G5 box; other site
639282005082	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
639282005083	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
639282005084	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
639282005085	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
639282005086	HflK protein; Region: hflK; TIGR01933
639282005087	HflC protein; Region: hflC; TIGR01932
639282005088	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
639282005089	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
639282005090	TrkA-N domain; Region: TrkA_N; pfam02254
639282005091	TrkA-C domain; Region: TrkA_C; pfam02080
639282005092	TrkA-N domain; Region: TrkA_N; pfam02254
639282005093	TrkA-C domain; Region: TrkA_C; pfam02080
639282005094	Cation transport protein; Region: TrkH; cl17365
639282005095	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
639282005096	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
639282005097	Acylphosphatase; Region: Acylphosphatase; pfam00708
639282005098	HypF finger; Region: zf-HYPF; pfam07503
639282005099	HypF finger; Region: zf-HYPF; pfam07503
639282005100	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
639282005101	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
639282005102	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
639282005103	Walker A/P-loop; other site
639282005104	ATP binding site [chemical binding]; other site
639282005105	Q-loop/lid; other site
639282005106	ABC transporter signature motif; other site
639282005107	Walker B; other site
639282005108	D-loop; other site
639282005109	H-loop/switch region; other site
639282005110	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
639282005111	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
639282005112	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
639282005113	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
639282005114	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282005115	dimer interface [polypeptide binding]; other site
639282005116	putative CheW interface [polypeptide binding]; other site
639282005117	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
639282005118	HAMP domain; Region: HAMP; pfam00672
639282005119	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
639282005120	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282005121	dimer interface [polypeptide binding]; other site
639282005122	putative CheW interface [polypeptide binding]; other site
639282005123	Hemerythrin; Region: Hemerythrin; cd12107
639282005124	Fe binding site [ion binding]; other site
639282005125	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
639282005126	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
639282005127	ligand binding site [chemical binding]; other site
639282005128	flexible hinge region; other site
639282005129	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
639282005130	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
639282005131	Na binding site [ion binding]; other site
639282005132	RNase III inhibitor; Provisional; Region: PRK00431
639282005133	ADP-ribose binding site [chemical binding]; other site
639282005134	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
639282005135	Predicted amidohydrolase [General function prediction only]; Region: COG0388
639282005136	active site
639282005137	catalytic triad [active]
639282005138	dimer interface [polypeptide binding]; other site
639282005139	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
639282005140	Coenzyme A transferase; Region: CoA_trans; smart00882
639282005141	Coenzyme A transferase; Region: CoA_trans; cl17247
639282005142	primosome assembly protein PriA; Validated; Region: PRK05580
639282005143	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
639282005144	ATP binding site [chemical binding]; other site
639282005145	putative Mg++ binding site [ion binding]; other site
639282005146	helicase superfamily c-terminal domain; Region: HELICc; smart00490
639282005147	ATP-binding site [chemical binding]; other site
639282005148	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
639282005149	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
639282005150	dimer interface [polypeptide binding]; other site
639282005151	anticodon binding site; other site
639282005152	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
639282005153	homodimer interface [polypeptide binding]; other site
639282005154	motif 1; other site
639282005155	active site
639282005156	motif 2; other site
639282005157	GAD domain; Region: GAD; pfam02938
639282005158	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
639282005159	motif 3; other site
639282005160	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
639282005161	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
639282005162	dimer interface [polypeptide binding]; other site
639282005163	motif 1; other site
639282005164	active site
639282005165	motif 2; other site
639282005166	motif 3; other site
639282005167	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
639282005168	anticodon binding site; other site
639282005169	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
639282005170	trimer interface [polypeptide binding]; other site
639282005171	putative Zn binding site [ion binding]; other site
639282005172	Probable gene remnant. Similar to the C-terminal region of Clostridium kluyveri DSM 555 rubredoxin FprA (448 aa). CKL_3321
639282005173	Probable gene remnant. Similar to the C-terminal region of rubrerythrin.
639282005174	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
639282005175	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
639282005176	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
639282005177	trimerization site [polypeptide binding]; other site
639282005178	active site
639282005179	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
639282005180	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
639282005181	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
639282005182	catalytic residue [active]
639282005183	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
639282005184	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
639282005185	non-specific DNA binding site [nucleotide binding]; other site
639282005186	salt bridge; other site
639282005187	sequence-specific DNA binding site [nucleotide binding]; other site
639282005188	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
639282005189	TPR repeat; Region: TPR_11; pfam13414
639282005190	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282005191	binding surface
639282005192	TPR motif; other site
639282005193	Tetratricopeptide repeat; Region: TPR_12; pfam13424
639282005194	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282005195	binding surface
639282005196	TPR motif; other site
639282005197	Tetratricopeptide repeat; Region: TPR_16; pfam13432
639282005198	pantothenate kinase; Reviewed; Region: PRK13318
639282005199	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
639282005200	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
639282005201	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
639282005202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282005203	active site
639282005204	phosphorylation site [posttranslational modification]
639282005205	intermolecular recognition site; other site
639282005206	dimerization interface [polypeptide binding]; other site
639282005207	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
639282005208	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
639282005209	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282005210	Zn2+ binding site [ion binding]; other site
639282005211	Mg2+ binding site [ion binding]; other site
639282005212	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282005213	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
639282005214	metal binding site 2 [ion binding]; metal-binding site
639282005215	putative DNA binding helix; other site
639282005216	metal binding site 1 [ion binding]; metal-binding site
639282005217	structural Zn2+ binding site [ion binding]; other site
639282005218	Rubrerythrin [Energy production and conversion]; Region: COG1592
639282005219	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
639282005220	binuclear metal center [ion binding]; other site
639282005221	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
639282005222	iron binding site [ion binding]; other site
639282005223	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
639282005224	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
639282005225	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
639282005226	putative RNA binding site [nucleotide binding]; other site
639282005227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282005228	S-adenosylmethionine binding site [chemical binding]; other site
639282005229	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
639282005230	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
639282005231	ATP binding site [chemical binding]; other site
639282005232	putative Mg++ binding site [ion binding]; other site
639282005233	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
639282005234	nucleotide binding region [chemical binding]; other site
639282005235	ATP-binding site [chemical binding]; other site
639282005236	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
639282005237	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
639282005238	active site
639282005239	substrate binding site [chemical binding]; other site
639282005240	catalytic site [active]
639282005241	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
639282005242	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
639282005243	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
639282005244	ligand binding site [chemical binding]; other site
639282005245	flexible hinge region; other site
639282005246	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
639282005247	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
639282005248	metal binding triad; other site
639282005249	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
639282005250	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
639282005251	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
639282005252	Na binding site [ion binding]; other site
639282005253	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
639282005254	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
639282005255	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
639282005256	putative dimer interface [polypeptide binding]; other site
639282005257	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
639282005258	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
639282005259	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
639282005260	active site
639282005261	catalytic site [active]
639282005262	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
639282005263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282005264	dimer interface [polypeptide binding]; other site
639282005265	conserved gate region; other site
639282005266	putative PBP binding loops; other site
639282005267	ABC-ATPase subunit interface; other site
639282005268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
639282005269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282005270	putative PBP binding loops; other site
639282005271	ABC-ATPase subunit interface; other site
639282005272	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
639282005273	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282005274	Walker A/P-loop; other site
639282005275	ATP binding site [chemical binding]; other site
639282005276	Q-loop/lid; other site
639282005277	ABC transporter signature motif; other site
639282005278	Walker B; other site
639282005279	D-loop; other site
639282005280	H-loop/switch region; other site
639282005281	TOBE domain; Region: TOBE_2; pfam08402
639282005282	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
639282005283	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
639282005284	Yqey-like protein; Region: YqeY; pfam09424
639282005285	MutS domain III; Region: MutS_III; pfam05192
639282005286	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282005287	Walker A/P-loop; other site
639282005288	ATP binding site [chemical binding]; other site
639282005289	Q-loop/lid; other site
639282005290	ABC transporter signature motif; other site
639282005291	Walker B; other site
639282005292	D-loop; other site
639282005293	H-loop/switch region; other site
639282005294	Smr domain; Region: Smr; pfam01713
639282005295	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
639282005296	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
639282005297	HlyD family secretion protein; Region: HlyD_3; pfam13437
639282005298	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
639282005299	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
639282005300	Walker A/P-loop; other site
639282005301	ATP binding site [chemical binding]; other site
639282005302	Q-loop/lid; other site
639282005303	ABC transporter signature motif; other site
639282005304	Walker B; other site
639282005305	D-loop; other site
639282005306	H-loop/switch region; other site
639282005307	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
639282005308	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
639282005309	Walker A/P-loop; other site
639282005310	ATP binding site [chemical binding]; other site
639282005311	Q-loop/lid; other site
639282005312	ABC transporter signature motif; other site
639282005313	Walker B; other site
639282005314	D-loop; other site
639282005315	H-loop/switch region; other site
639282005316	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
639282005317	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
639282005318	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
639282005319	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
639282005320	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
639282005321	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
639282005322	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
639282005323	HflX GTPase family; Region: HflX; cd01878
639282005324	G1 box; other site
639282005325	GTP/Mg2+ binding site [chemical binding]; other site
639282005326	Switch I region; other site
639282005327	G2 box; other site
639282005328	G3 box; other site
639282005329	Switch II region; other site
639282005330	G4 box; other site
639282005331	G5 box; other site
639282005332	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
639282005333	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
639282005334	dimer interface [polypeptide binding]; other site
639282005335	putative functional site; other site
639282005336	putative MPT binding site; other site
639282005337	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
639282005338	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
639282005339	active site
639282005340	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282005341	dimerization interface [polypeptide binding]; other site
639282005342	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
639282005343	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282005344	dimer interface [polypeptide binding]; other site
639282005345	putative CheW interface [polypeptide binding]; other site
639282005346	putative peptidase; Provisional; Region: PRK11649
639282005347	Peptidase family M23; Region: Peptidase_M23; pfam01551
639282005348	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
639282005349	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
639282005350	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
639282005351	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
639282005352	Walker A/P-loop; other site
639282005353	ATP binding site [chemical binding]; other site
639282005354	Q-loop/lid; other site
639282005355	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
639282005356	ABC transporter signature motif; other site
639282005357	Walker B; other site
639282005358	D-loop; other site
639282005359	H-loop/switch region; other site
639282005360	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
639282005361	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
639282005362	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
639282005363	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
639282005364	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
639282005365	N-acetyl-D-glucosamine binding site [chemical binding]; other site
639282005366	catalytic residue [active]
639282005367	amidophosphoribosyltransferase; Provisional; Region: PRK09123
639282005368	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
639282005369	active site
639282005370	tetramer interface [polypeptide binding]; other site
639282005371	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
639282005372	active site
639282005373	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
639282005374	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
639282005375	dimerization interface [polypeptide binding]; other site
639282005376	ATP binding site [chemical binding]; other site
639282005377	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
639282005378	dimerization interface [polypeptide binding]; other site
639282005379	ATP binding site [chemical binding]; other site
639282005380	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
639282005381	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
639282005382	putative active site [active]
639282005383	catalytic triad [active]
639282005384	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
639282005385	Transcriptional regulators [Transcription]; Region: GntR; COG1802
639282005386	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
639282005387	DNA-binding site [nucleotide binding]; DNA binding site
639282005388	FCD domain; Region: FCD; pfam07729
639282005389	Transcriptional regulators [Transcription]; Region: GntR; COG1802
639282005390	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
639282005391	DNA-binding site [nucleotide binding]; DNA binding site
639282005392	FCD domain; Region: FCD; pfam07729
639282005393	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
639282005394	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
639282005395	active site
639282005396	nucleophile elbow; other site
639282005397	short chain dehydrogenase; Provisional; Region: PRK07454
639282005398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
639282005399	NAD(P) binding site [chemical binding]; other site
639282005400	active site
639282005401	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
639282005402	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
639282005403	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
639282005404	catalytic loop [active]
639282005405	iron binding site [ion binding]; other site
639282005406	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
639282005407	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
639282005408	molybdopterin cofactor binding site; other site
639282005409	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
639282005410	putative oxidoreductase; Provisional; Region: PRK12831
639282005411	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
639282005412	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
639282005413	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
639282005414	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
639282005415	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
639282005416	thiamine phosphate binding site [chemical binding]; other site
639282005417	active site
639282005418	pyrophosphate binding site [ion binding]; other site
639282005419	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
639282005420	thiamine-monophosphate kinase; Region: thiL; TIGR01379
639282005421	ATP binding site [chemical binding]; other site
639282005422	dimerization interface [polypeptide binding]; other site
639282005423	Transcriptional regulator; Region: Rrf2; pfam02082
639282005424	Rrf2 family protein; Region: rrf2_super; TIGR00738
639282005425	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
639282005426	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
639282005427	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
639282005428	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
639282005429	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
639282005430	putative tRNA-binding site [nucleotide binding]; other site
639282005431	B3/4 domain; Region: B3_4; pfam03483
639282005432	tRNA synthetase B5 domain; Region: B5; smart00874
639282005433	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
639282005434	dimer interface [polypeptide binding]; other site
639282005435	motif 1; other site
639282005436	motif 3; other site
639282005437	motif 2; other site
639282005438	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
639282005439	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
639282005440	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
639282005441	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
639282005442	dimer interface [polypeptide binding]; other site
639282005443	motif 1; other site
639282005444	active site
639282005445	motif 2; other site
639282005446	motif 3; other site
639282005447	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
639282005448	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
639282005449	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
639282005450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
639282005451	Major Facilitator Superfamily; Region: MFS_1; pfam07690
639282005452	putative substrate translocation pore; other site
639282005453	argininosuccinate synthase; Provisional; Region: PRK13820
639282005454	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
639282005455	ANP binding site [chemical binding]; other site
639282005456	Substrate Binding Site II [chemical binding]; other site
639282005457	Substrate Binding Site I [chemical binding]; other site
639282005458	ornithine carbamoyltransferase; Provisional; Region: PRK00779
639282005459	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
639282005460	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
639282005461	acetylornithine aminotransferase; Provisional; Region: PRK02627
639282005462	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
639282005463	inhibitor-cofactor binding pocket; inhibition site
639282005464	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282005465	catalytic residue [active]
639282005466	ornithine cyclodeaminase; Validated; Region: PRK08618
639282005467	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
639282005468	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
639282005469	Proline racemase; Region: Pro_racemase; pfam05544
639282005470	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
639282005471	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
639282005472	DNA-binding site [nucleotide binding]; DNA binding site
639282005473	RNA-binding motif; other site
639282005474	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
639282005475	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282005476	FeS/SAM binding site; other site
639282005477	Pseudogene. Similar to anaerobic ribonucleoside triphosphate reductase. This CDS appears to have a frameshift mutation
639282005478	Probable gene remnant. Similar to the C-terminal region of Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903) anaerobic ribonucleoside triphosphate reductase (695 aa). Csac_0774
639282005479	Probable gene remnant. Similar to the N-terminal region of Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903) anaerobic ribonucleoside triphosphate reductase (695 aa). Csac_0774
639282005480	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
639282005481	Ligand Binding Site [chemical binding]; other site
639282005482	TIGR03546 family protein; Region: TIGR03546
639282005483	B12 binding domain; Region: B12-binding; pfam02310
639282005484	B12 binding site [chemical binding]; other site
639282005485	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
639282005486	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282005487	FeS/SAM binding site; other site
639282005488	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
639282005489	hypothetical protein; Provisional; Region: PRK04194
639282005490	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
639282005491	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
639282005492	minor groove reading motif; other site
639282005493	helix-hairpin-helix signature motif; other site
639282005494	substrate binding pocket [chemical binding]; other site
639282005495	active site
639282005496	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
639282005497	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
639282005498	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
639282005499	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282005500	S-adenosylmethionine binding site [chemical binding]; other site
639282005501	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
639282005502	HDOD domain; Region: HDOD; pfam08668
639282005503	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282005504	Zn2+ binding site [ion binding]; other site
639282005505	Mg2+ binding site [ion binding]; other site
639282005506	Response regulator receiver domain; Region: Response_reg; pfam00072
639282005507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282005508	active site
639282005509	phosphorylation site [posttranslational modification]
639282005510	intermolecular recognition site; other site
639282005511	dimerization interface [polypeptide binding]; other site
639282005512	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
639282005513	HSP70 interaction site [polypeptide binding]; other site
639282005514	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282005515	binding surface
639282005516	TPR motif; other site
639282005517	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
639282005518	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
639282005519	motif II; other site
639282005520	NMD protein affecting ribosome stability and mRNA decay [Translation, ribosomal structure and biogenesis]; Region: NMD3; COG1499
639282005521	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
639282005522	homotrimer interaction site [polypeptide binding]; other site
639282005523	zinc binding site [ion binding]; other site
639282005524	CDP-binding sites; other site
639282005525	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
639282005526	2-keto-3-deoxygluconate permease; Region: KdgT; cl14653
639282005527	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282005528	S-adenosylmethionine binding site [chemical binding]; other site
639282005529	Methyltransferase domain; Region: Methyltransf_11; pfam08241
639282005530	S-adenosylmethionine binding site [chemical binding]; other site
639282005531	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
639282005532	RuvA N terminal domain; Region: RuvA_N; pfam01330
639282005533	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
639282005534	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
639282005535	active site
639282005536	putative DNA-binding cleft [nucleotide binding]; other site
639282005537	dimer interface [polypeptide binding]; other site
639282005538	hypothetical protein; Validated; Region: PRK00110
639282005539	2-isopropylmalate synthase; Validated; Region: PRK00915
639282005540	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
639282005541	active site
639282005542	catalytic residues [active]
639282005543	metal binding site [ion binding]; metal-binding site
639282005544	RNA polymerase Rpb5, N-terminal domain; Region: RNA_pol_Rpb5_N; pfam03871
639282005545	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
639282005546	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
639282005547	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
639282005548	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
639282005549	ketol-acid reductoisomerase; Provisional; Region: PRK05479
639282005550	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
639282005551	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
639282005552	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
639282005553	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
639282005554	putative valine binding site [chemical binding]; other site
639282005555	dimer interface [polypeptide binding]; other site
639282005556	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
639282005557	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
639282005558	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
639282005559	PYR/PP interface [polypeptide binding]; other site
639282005560	dimer interface [polypeptide binding]; other site
639282005561	TPP binding site [chemical binding]; other site
639282005562	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
639282005563	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
639282005564	TPP-binding site [chemical binding]; other site
639282005565	dimer interface [polypeptide binding]; other site
639282005566	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
639282005567	6-phosphogluconate dehydratase; Region: edd; TIGR01196
639282005568	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
639282005569	Na binding site [ion binding]; other site
639282005570	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
639282005571	GAF domain; Region: GAF_3; pfam13492
639282005572	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
639282005573	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
639282005574	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
639282005575	Predicted permease; Region: DUF318; pfam03773
639282005576	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
639282005577	dimerization interface [polypeptide binding]; other site
639282005578	putative DNA binding site [nucleotide binding]; other site
639282005579	putative Zn2+ binding site [ion binding]; other site
639282005580	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
639282005581	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
639282005582	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
639282005583	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
639282005584	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
639282005585	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
639282005586	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
639282005587	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
639282005588	Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378
639282005589	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282005590	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
639282005591	Walker A/P-loop; other site
639282005592	ATP binding site [chemical binding]; other site
639282005593	Q-loop/lid; other site
639282005594	ABC transporter signature motif; other site
639282005595	Walker B; other site
639282005596	D-loop; other site
639282005597	H-loop/switch region; other site
639282005598	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
639282005599	ResB-like family; Region: ResB; pfam05140
639282005600	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
639282005601	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
639282005602	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
639282005603	substrate binding pocket [chemical binding]; other site
639282005604	dimer interface [polypeptide binding]; other site
639282005605	inhibitor binding site; inhibition site
639282005606	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
639282005607	B12 binding site [chemical binding]; other site
639282005608	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
639282005609	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
639282005610	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
639282005611	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
639282005612	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
639282005613	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
639282005614	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
639282005615	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
639282005616	P loop nucleotide binding; other site
639282005617	Ferredoxin [Energy production and conversion]; Region: COG1146
639282005618	switch II; other site
639282005619	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
639282005620	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
639282005621	P loop nucleotide binding; other site
639282005622	switch II; other site
639282005623	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282005624	Walker A/P-loop; other site
639282005625	ATP binding site [chemical binding]; other site
639282005626	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
639282005627	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
639282005628	DNA binding residues [nucleotide binding]
639282005629	FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764
639282005630	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
639282005631	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
639282005632	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
639282005633	4Fe-4S binding domain; Region: Fer4; pfam00037
639282005634	thiosulfate reductase PhsA; Provisional; Region: PRK15488
639282005635	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
639282005636	putative [Fe4-S4] binding site [ion binding]; other site
639282005637	putative molybdopterin cofactor binding site [chemical binding]; other site
639282005638	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
639282005639	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
639282005640	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
639282005641	putative molybdopterin cofactor binding site; other site
639282005642	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
639282005643	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
639282005644	active site
639282005645	FMN binding site [chemical binding]; other site
639282005646	substrate binding site [chemical binding]; other site
639282005647	putative catalytic residue [active]
639282005648	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
639282005649	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
639282005650	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
639282005651	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
639282005652	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
639282005653	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
639282005654	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
639282005655	thiosulfate reductase PhsA; Provisional; Region: PRK15488
639282005656	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
639282005657	putative [Fe4-S4] binding site [ion binding]; other site
639282005658	putative molybdopterin cofactor binding site [chemical binding]; other site
639282005659	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
639282005660	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
639282005661	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
639282005662	putative molybdopterin cofactor binding site; other site
639282005663	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
639282005664	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
639282005665	DNA binding residues [nucleotide binding]
639282005666	Cupin domain; Region: Cupin_2; cl17218
639282005667	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
639282005668	putative CheA interaction surface; other site
639282005669	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
639282005670	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
639282005671	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
639282005672	P-loop; other site
639282005673	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
639282005674	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
639282005675	Found in ATP-dependent protease La (LON); Region: LON; smart00464
639282005676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282005677	Walker A motif; other site
639282005678	ATP binding site [chemical binding]; other site
639282005679	Walker B motif; other site
639282005680	arginine finger; other site
639282005681	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
639282005682	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
639282005683	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
639282005684	putative dimer interface [polypeptide binding]; other site
639282005685	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
639282005686	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
639282005687	active site
639282005688	tetramer interface; other site
639282005689	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
639282005690	putative ligand binding pocket/active site [active]
639282005691	putative metal binding site [ion binding]; other site
639282005692	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
639282005693	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282005694	FeS/SAM binding site; other site
639282005695	Response regulator receiver domain; Region: Response_reg; pfam00072
639282005696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282005697	active site
639282005698	phosphorylation site [posttranslational modification]
639282005699	intermolecular recognition site; other site
639282005700	dimerization interface [polypeptide binding]; other site
639282005701	GAF domain; Region: GAF; cl17456
639282005702	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
639282005703	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282005704	Zn2+ binding site [ion binding]; other site
639282005705	Mg2+ binding site [ion binding]; other site
639282005706	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
639282005707	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
639282005708	Probable gene remnant. Similar to the C-terminal region of Geobacillus kaustophilus flagellar motor switch protein FliY (393 aa). GK1231
639282005709	Probable gene remnant. Similar to the C-terminal region of flagellar motor switch protein FliN/FliY
639282005710	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
639282005711	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
639282005712	flagellar motor protein MotS; Reviewed; Region: PRK06925
639282005713	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
639282005714	ligand binding site [chemical binding]; other site
639282005715	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
639282005716	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
639282005717	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
639282005718	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
639282005719	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
639282005720	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
639282005721	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
639282005722	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
639282005723	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
639282005724	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
639282005725	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
639282005726	AMIN domain; Region: AMIN; pfam11741
639282005727	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
639282005728	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
639282005729	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
639282005730	Pilus assembly protein, PilP; Region: PilP; pfam04351
639282005731	Pilus assembly protein, PilO; Region: PilO; cl01234
639282005732	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
639282005733	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
639282005734	Competence protein A; Region: Competence_A; pfam11104
639282005735	nucleotide binding site [chemical binding]; other site
639282005736	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
639282005737	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
639282005738	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
639282005739	dimerization interface [polypeptide binding]; other site
639282005740	ATP binding site [chemical binding]; other site
639282005741	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
639282005742	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
639282005743	HupF/HypC family; Region: HupF_HypC; pfam01455
639282005744	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
639282005745	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
639282005746	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
639282005747	heme-binding residues [chemical binding]; other site
639282005748	ATP synthase subunit C; Region: ATP-synt_C; cl00466
639282005749	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
639282005750	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
639282005751	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
639282005752	Nitrogen regulatory protein P-II; Region: P-II; smart00938
639282005753	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
639282005754	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
639282005755	inhibitor-cofactor binding pocket; inhibition site
639282005756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282005757	catalytic residue [active]
639282005758	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
639282005759	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
639282005760	Metal-binding active site; metal-binding site
639282005761	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
639282005762	intersubunit interface [polypeptide binding]; other site
639282005763	active site
639282005764	Zn2+ binding site [ion binding]; other site
639282005765	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
639282005766	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282005767	Walker A/P-loop; other site
639282005768	ATP binding site [chemical binding]; other site
639282005769	Q-loop/lid; other site
639282005770	ABC transporter signature motif; other site
639282005771	Walker B; other site
639282005772	D-loop; other site
639282005773	H-loop/switch region; other site
639282005774	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
639282005775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282005776	Walker A/P-loop; other site
639282005777	ATP binding site [chemical binding]; other site
639282005778	Q-loop/lid; other site
639282005779	ABC transporter signature motif; other site
639282005780	Walker B; other site
639282005781	D-loop; other site
639282005782	H-loop/switch region; other site
639282005783	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
639282005784	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
639282005785	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
639282005786	alphaNTD - beta interaction site [polypeptide binding]; other site
639282005787	alphaNTD homodimer interface [polypeptide binding]; other site
639282005788	alphaNTD - beta' interaction site [polypeptide binding]; other site
639282005789	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
639282005790	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
639282005791	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
639282005792	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
639282005793	RNA binding surface [nucleotide binding]; other site
639282005794	30S ribosomal protein S11; Validated; Region: PRK05309
639282005795	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
639282005796	30S ribosomal protein S13; Region: bact_S13; TIGR03631
639282005797	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
639282005798	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
639282005799	rRNA binding site [nucleotide binding]; other site
639282005800	predicted 30S ribosome binding site; other site
639282005801	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
639282005802	active site
639282005803	adenylate kinase; Reviewed; Region: adk; PRK00279
639282005804	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
639282005805	AMP-binding site [chemical binding]; other site
639282005806	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
639282005807	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
639282005808	SecY translocase; Region: SecY; pfam00344
639282005809	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
639282005810	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
639282005811	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
639282005812	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
639282005813	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
639282005814	23S rRNA interface [nucleotide binding]; other site
639282005815	5S rRNA interface [nucleotide binding]; other site
639282005816	L27 interface [polypeptide binding]; other site
639282005817	L5 interface [polypeptide binding]; other site
639282005818	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
639282005819	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
639282005820	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
639282005821	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
639282005822	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
639282005823	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
639282005824	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
639282005825	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
639282005826	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
639282005827	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
639282005828	RNA binding site [nucleotide binding]; other site
639282005829	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
639282005830	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
639282005831	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
639282005832	23S rRNA interface [nucleotide binding]; other site
639282005833	putative translocon interaction site; other site
639282005834	signal recognition particle (SRP54) interaction site; other site
639282005835	L23 interface [polypeptide binding]; other site
639282005836	trigger factor interaction site; other site
639282005837	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
639282005838	23S rRNA interface [nucleotide binding]; other site
639282005839	5S rRNA interface [nucleotide binding]; other site
639282005840	putative antibiotic binding site [chemical binding]; other site
639282005841	L25 interface [polypeptide binding]; other site
639282005842	L27 interface [polypeptide binding]; other site
639282005843	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
639282005844	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
639282005845	G-X-X-G motif; other site
639282005846	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
639282005847	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
639282005848	putative translocon binding site; other site
639282005849	protein-rRNA interface [nucleotide binding]; other site
639282005850	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
639282005851	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
639282005852	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
639282005853	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
639282005854	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
639282005855	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
639282005856	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
639282005857	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
639282005858	elongation factor Tu; Reviewed; Region: PRK00049
639282005859	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
639282005860	G1 box; other site
639282005861	GEF interaction site [polypeptide binding]; other site
639282005862	GTP/Mg2+ binding site [chemical binding]; other site
639282005863	Switch I region; other site
639282005864	G2 box; other site
639282005865	G3 box; other site
639282005866	Switch II region; other site
639282005867	G4 box; other site
639282005868	G5 box; other site
639282005869	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
639282005870	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
639282005871	Antibiotic Binding Site [chemical binding]; other site
639282005872	elongation factor G; Reviewed; Region: PRK00007
639282005873	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
639282005874	G1 box; other site
639282005875	putative GEF interaction site [polypeptide binding]; other site
639282005876	GTP/Mg2+ binding site [chemical binding]; other site
639282005877	Switch I region; other site
639282005878	G2 box; other site
639282005879	G3 box; other site
639282005880	Switch II region; other site
639282005881	G4 box; other site
639282005882	G5 box; other site
639282005883	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
639282005884	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
639282005885	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
639282005886	30S ribosomal protein S7; Validated; Region: PRK05302
639282005887	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
639282005888	S17 interaction site [polypeptide binding]; other site
639282005889	S8 interaction site; other site
639282005890	16S rRNA interaction site [nucleotide binding]; other site
639282005891	streptomycin interaction site [chemical binding]; other site
639282005892	23S rRNA interaction site [nucleotide binding]; other site
639282005893	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
639282005894	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
639282005895	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
639282005896	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
639282005897	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
639282005898	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
639282005899	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
639282005900	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
639282005901	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
639282005902	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
639282005903	DNA binding site [nucleotide binding]
639282005904	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
639282005905	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
639282005906	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
639282005907	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
639282005908	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
639282005909	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
639282005910	RPB12 interaction site [polypeptide binding]; other site
639282005911	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
639282005912	RPB3 interaction site [polypeptide binding]; other site
639282005913	RPB1 interaction site [polypeptide binding]; other site
639282005914	RPB11 interaction site [polypeptide binding]; other site
639282005915	RPB10 interaction site [polypeptide binding]; other site
639282005916	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
639282005917	core dimer interface [polypeptide binding]; other site
639282005918	peripheral dimer interface [polypeptide binding]; other site
639282005919	L10 interface [polypeptide binding]; other site
639282005920	L11 interface [polypeptide binding]; other site
639282005921	putative EF-Tu interaction site [polypeptide binding]; other site
639282005922	putative EF-G interaction site [polypeptide binding]; other site
639282005923	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
639282005924	23S rRNA interface [nucleotide binding]; other site
639282005925	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
639282005926	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
639282005927	mRNA/rRNA interface [nucleotide binding]; other site
639282005928	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
639282005929	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
639282005930	23S rRNA interface [nucleotide binding]; other site
639282005931	L7/L12 interface [polypeptide binding]; other site
639282005932	putative thiostrepton binding site; other site
639282005933	L25 interface [polypeptide binding]; other site
639282005934	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
639282005935	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
639282005936	putative homodimer interface [polypeptide binding]; other site
639282005937	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
639282005938	heterodimer interface [polypeptide binding]; other site
639282005939	homodimer interface [polypeptide binding]; other site
639282005940	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
639282005941	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
639282005942	elongation factor Tu; Reviewed; Region: PRK00049
639282005943	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
639282005944	G1 box; other site
639282005945	GEF interaction site [polypeptide binding]; other site
639282005946	GTP/Mg2+ binding site [chemical binding]; other site
639282005947	Switch I region; other site
639282005948	G2 box; other site
639282005949	G3 box; other site
639282005950	Switch II region; other site
639282005951	G4 box; other site
639282005952	G5 box; other site
639282005953	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
639282005954	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
639282005955	Antibiotic Binding Site [chemical binding]; other site
639282005956	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
639282005957	Ligand Binding Site [chemical binding]; other site
639282005958	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
639282005959	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
639282005960	homodimer interface [polypeptide binding]; other site
639282005961	metal binding site [ion binding]; metal-binding site
639282005962	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
639282005963	homodimer interface [polypeptide binding]; other site
639282005964	active site
639282005965	putative chemical substrate binding site [chemical binding]; other site
639282005966	metal binding site [ion binding]; metal-binding site
639282005967	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
639282005968	putative active site pocket [active]
639282005969	dimerization interface [polypeptide binding]; other site
639282005970	putative catalytic residue [active]
639282005971	glutamate racemase; Provisional; Region: PRK00865
639282005972	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
639282005973	flagellin; Provisional; Region: PRK12806
639282005974	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
639282005975	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
639282005976	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
639282005977	ATP binding site [chemical binding]; other site
639282005978	Mg++ binding site [ion binding]; other site
639282005979	motif III; other site
639282005980	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
639282005981	nucleotide binding region [chemical binding]; other site
639282005982	ATP-binding site [chemical binding]; other site
639282005983	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
639282005984	RNA binding site [nucleotide binding]; other site
639282005985	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
639282005986	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
639282005987	ABC transporter; Region: ABC_tran_2; pfam12848
639282005988	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
639282005989	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
639282005990	GcpE protein; Region: GcpE; pfam04551
639282005991	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
639282005992	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
639282005993	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
639282005994	active site
639282005995	Int/Topo IB signature motif; other site
639282005996	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
639282005997	Glucose inhibited division protein A; Region: GIDA; pfam01134
639282005998	DNA topoisomerase I; Validated; Region: PRK06599
639282005999	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
639282006000	active site
639282006001	interdomain interaction site; other site
639282006002	putative metal-binding site [ion binding]; other site
639282006003	nucleotide binding site [chemical binding]; other site
639282006004	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
639282006005	domain I; other site
639282006006	DNA binding groove [nucleotide binding]
639282006007	phosphate binding site [ion binding]; other site
639282006008	domain II; other site
639282006009	domain III; other site
639282006010	nucleotide binding site [chemical binding]; other site
639282006011	catalytic site [active]
639282006012	domain IV; other site
639282006013	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
639282006014	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
639282006015	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
639282006016	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
639282006017	Protein of unknown function (DUF494); Region: DUF494; cl01103
639282006018	DNA protecting protein DprA; Region: dprA; TIGR00732
639282006019	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
639282006020	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
639282006021	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
639282006022	metal binding site [ion binding]; metal-binding site
639282006023	dimer interface [polypeptide binding]; other site
639282006024	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
639282006025	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
639282006026	NAD binding site [chemical binding]; other site
639282006027	homotetramer interface [polypeptide binding]; other site
639282006028	homodimer interface [polypeptide binding]; other site
639282006029	substrate binding site [chemical binding]; other site
639282006030	active site
639282006031	DNA repair protein RadA; Provisional; Region: PRK11823
639282006032	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
639282006033	Walker A motif; other site
639282006034	ATP binding site [chemical binding]; other site
639282006035	Walker B motif; other site
639282006036	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
639282006037	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
639282006038	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282006039	Walker A motif; other site
639282006040	ATP binding site [chemical binding]; other site
639282006041	Walker B motif; other site
639282006042	arginine finger; other site
639282006043	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
639282006044	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282006045	Zn2+ binding site [ion binding]; other site
639282006046	Mg2+ binding site [ion binding]; other site
639282006047	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
639282006048	EamA-like transporter family; Region: EamA; cl17759
639282006049	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
639282006050	EamA-like transporter family; Region: EamA; pfam00892
639282006051	EamA-like transporter family; Region: EamA; pfam00892
639282006052	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
639282006053	EamA-like transporter family; Region: EamA; pfam00892
639282006054	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
639282006055	EamA-like transporter family; Region: EamA; pfam00892
639282006056	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
639282006057	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
639282006058	propionate/acetate kinase; Provisional; Region: PRK12379
639282006059	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
639282006060	heme-binding residues [chemical binding]; other site
639282006061	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
639282006062	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
639282006063	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
639282006064	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
639282006065	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
639282006066	[4Fe-4S] binding site [ion binding]; other site
639282006067	molybdopterin cofactor binding site; other site
639282006068	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
639282006069	molybdopterin cofactor binding site; other site
639282006070	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
639282006071	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
639282006072	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
639282006073	4Fe-4S binding domain; Region: Fer4_5; pfam12801
639282006074	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
639282006075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282006076	active site
639282006077	phosphorylation site [posttranslational modification]
639282006078	intermolecular recognition site; other site
639282006079	dimerization interface [polypeptide binding]; other site
639282006080	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
639282006081	DNA binding site [nucleotide binding]
639282006082	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
639282006083	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282006084	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282006085	dimerization interface [polypeptide binding]; other site
639282006086	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282006087	dimer interface [polypeptide binding]; other site
639282006088	phosphorylation site [posttranslational modification]
639282006089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282006090	ATP binding site [chemical binding]; other site
639282006091	G-X-G motif; other site
639282006092	Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159
639282006093	putative homodimer interface [polypeptide binding]; other site
639282006094	putative homotetramer interface [polypeptide binding]; other site
639282006095	putative allosteric switch controlling residues; other site
639282006096	putative metal binding site [ion binding]; other site
639282006097	putative homodimer-homodimer interface [polypeptide binding]; other site
639282006098	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
639282006099	metal-binding site [ion binding]
639282006100	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
639282006101	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
639282006102	FMN binding site [chemical binding]; other site
639282006103	substrate binding site [chemical binding]; other site
639282006104	putative catalytic residue [active]
639282006105	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
639282006106	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
639282006107	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
639282006108	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
639282006109	Ligand binding site [chemical binding]; other site
639282006110	Electron transfer flavoprotein domain; Region: ETF; pfam01012
639282006111	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
639282006112	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
639282006113	4Fe-4S binding domain; Region: Fer4; cl02805
639282006114	Cysteine-rich domain; Region: CCG; pfam02754
639282006115	Cysteine-rich domain; Region: CCG; pfam02754
639282006116	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
639282006117	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
639282006118	FAD binding site [chemical binding]; other site
639282006119	homotetramer interface [polypeptide binding]; other site
639282006120	substrate binding pocket [chemical binding]; other site
639282006121	catalytic base [active]
639282006122	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
639282006123	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
639282006124	substrate binding site [chemical binding]; other site
639282006125	oxyanion hole (OAH) forming residues; other site
639282006126	trimer interface [polypeptide binding]; other site
639282006127	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
639282006128	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
639282006129	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
639282006130	putative acyltransferase; Provisional; Region: PRK05790
639282006131	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
639282006132	dimer interface [polypeptide binding]; other site
639282006133	active site
639282006134	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
639282006135	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
639282006136	DNA binding residues [nucleotide binding]
639282006137	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
639282006138	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
639282006139	active site
639282006140	Protein of unknown function (DUF554); Region: DUF554; pfam04474
639282006141	Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar3; cd09131
639282006142	PLD-like domain; Region: PLDc_2; pfam13091
639282006143	putative active site [active]
639282006144	putative catalytic site [active]
639282006145	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
639282006146	G1 box; other site
639282006147	GTP/Mg2+ binding site [chemical binding]; other site
639282006148	Switch I region; other site
639282006149	G2 box; other site
639282006150	G3 box; other site
639282006151	Switch II region; other site
639282006152	G4 box; other site
639282006153	G5 box; other site
639282006154	DHH family; Region: DHH; pfam01368
639282006155	Uncharacterized conserved protein [Function unknown]; Region: COG0432
639282006156	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
639282006157	DctM-like transporters; Region: DctM; pfam06808
639282006158	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
639282006159	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
639282006160	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
639282006161	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
639282006162	GIY-YIG motif/motif A; other site
639282006163	active site
639282006164	catalytic site [active]
639282006165	putative DNA binding site [nucleotide binding]; other site
639282006166	metal binding site [ion binding]; metal-binding site
639282006167	UvrB/uvrC motif; Region: UVR; pfam02151
639282006168	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
639282006169	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
639282006170	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
639282006171	metal binding site [ion binding]; metal-binding site
639282006172	dimer interface [polypeptide binding]; other site
639282006173	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
639282006174	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282006175	FeS/SAM binding site; other site
639282006176	ATP-grasp domain; Region: ATP-grasp_4; cl17255
639282006177	Transcriptional regulators [Transcription]; Region: GntR; COG1802
639282006178	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
639282006179	DNA-binding site [nucleotide binding]; DNA binding site
639282006180	FCD domain; Region: FCD; pfam07729
639282006181	PAS domain S-box; Region: sensory_box; TIGR00229
639282006182	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
639282006183	PAS domain; Region: PAS_9; pfam13426
639282006184	putative active site [active]
639282006185	heme pocket [chemical binding]; other site
639282006186	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282006187	metal binding site [ion binding]; metal-binding site
639282006188	active site
639282006189	I-site; other site
639282006190	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
639282006191	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282006192	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282006193	metal binding site [ion binding]; metal-binding site
639282006194	active site
639282006195	I-site; other site
639282006196	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
639282006197	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
639282006198	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282006199	dimerization interface [polypeptide binding]; other site
639282006200	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
639282006201	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282006202	dimer interface [polypeptide binding]; other site
639282006203	putative CheW interface [polypeptide binding]; other site
639282006204	PAS domain; Region: PAS_9; pfam13426
639282006205	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
639282006206	putative active site [active]
639282006207	heme pocket [chemical binding]; other site
639282006208	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
639282006209	GAF domain; Region: GAF; pfam01590
639282006210	PAS domain S-box; Region: sensory_box; TIGR00229
639282006211	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
639282006212	putative active site [active]
639282006213	heme pocket [chemical binding]; other site
639282006214	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282006215	metal binding site [ion binding]; metal-binding site
639282006216	active site
639282006217	I-site; other site
639282006218	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
639282006219	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
639282006220	[Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693
639282006221	metal binding triad; other site
639282006222	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
639282006223	HD domain; Region: HD; pfam01966
639282006224	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
639282006225	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
639282006226	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
639282006227	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
639282006228	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
639282006229	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
639282006230	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
639282006231	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
639282006232	active site residue [active]
639282006233	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
639282006234	ATP binding site [chemical binding]; other site
639282006235	active site
639282006236	substrate binding site [chemical binding]; other site
639282006237	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
639282006238	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
639282006239	N-acetyl-D-glucosamine binding site [chemical binding]; other site
639282006240	catalytic residue [active]
639282006241	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
639282006242	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
639282006243	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
639282006244	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
639282006245	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
639282006246	active site
639282006247	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
639282006248	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
639282006249	putative DNA binding site [nucleotide binding]; other site
639282006250	putative Zn2+ binding site [ion binding]; other site
639282006251	AsnC family; Region: AsnC_trans_reg; pfam01037
639282006252	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
639282006253	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
639282006254	minor groove reading motif; other site
639282006255	helix-hairpin-helix signature motif; other site
639282006256	substrate binding pocket [chemical binding]; other site
639282006257	active site
639282006258	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
639282006259	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
639282006260	Methyltransferase domain; Region: Methyltransf_31; pfam13847
639282006261	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282006262	S-adenosylmethionine binding site [chemical binding]; other site
639282006263	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
639282006264	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282006265	Walker A/P-loop; other site
639282006266	ATP binding site [chemical binding]; other site
639282006267	Q-loop/lid; other site
639282006268	ABC transporter signature motif; other site
639282006269	Walker B; other site
639282006270	D-loop; other site
639282006271	H-loop/switch region; other site
639282006272	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
639282006273	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
639282006274	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
639282006275	Cl- selectivity filter; other site
639282006276	Cl- binding residues [ion binding]; other site
639282006277	pore gating glutamate residue; other site
639282006278	dimer interface [polypeptide binding]; other site
639282006279	FOG: CBS domain [General function prediction only]; Region: COG0517
639282006280	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
639282006281	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
639282006282	active site
639282006283	catalytic site [active]
639282006284	substrate binding site [chemical binding]; other site
639282006285	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
639282006286	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
639282006287	S-adenosylmethionine binding site [chemical binding]; other site
639282006288	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
639282006289	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
639282006290	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
639282006291	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
639282006292	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
639282006293	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
639282006294	FtsX-like permease family; Region: FtsX; pfam02687
639282006295	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
639282006296	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
639282006297	Walker A/P-loop; other site
639282006298	ATP binding site [chemical binding]; other site
639282006299	Q-loop/lid; other site
639282006300	ABC transporter signature motif; other site
639282006301	Walker B; other site
639282006302	D-loop; other site
639282006303	H-loop/switch region; other site
639282006304	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
639282006305	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
639282006306	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
639282006307	SmpB-tmRNA interface; other site
639282006308	Domain of unknown function DUF77; Region: DUF77; pfam01910
639282006309	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
639282006310	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282006311	S-adenosylmethionine binding site [chemical binding]; other site
639282006312	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
639282006313	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
639282006314	gamma subunit interface [polypeptide binding]; other site
639282006315	epsilon subunit interface [polypeptide binding]; other site
639282006316	LBP interface [polypeptide binding]; other site
639282006317	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
639282006318	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
639282006319	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
639282006320	alpha subunit interaction interface [polypeptide binding]; other site
639282006321	Walker A motif; other site
639282006322	ATP binding site [chemical binding]; other site
639282006323	Walker B motif; other site
639282006324	inhibitor binding site; inhibition site
639282006325	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
639282006326	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
639282006327	core domain interface [polypeptide binding]; other site
639282006328	delta subunit interface [polypeptide binding]; other site
639282006329	epsilon subunit interface [polypeptide binding]; other site
639282006330	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
639282006331	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
639282006332	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
639282006333	beta subunit interaction interface [polypeptide binding]; other site
639282006334	Walker A motif; other site
639282006335	ATP binding site [chemical binding]; other site
639282006336	Walker B motif; other site
639282006337	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
639282006338	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
639282006339	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
639282006340	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
639282006341	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
639282006342	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
639282006343	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
639282006344	Phosphoglycerate kinase; Region: PGK; pfam00162
639282006345	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
639282006346	substrate binding site [chemical binding]; other site
639282006347	hinge regions; other site
639282006348	ADP binding site [chemical binding]; other site
639282006349	catalytic site [active]
639282006350	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
639282006351	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
639282006352	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
639282006353	PAS domain; Region: PAS_9; pfam13426
639282006354	Double zinc ribbon; Region: DZR; pfam12773
639282006355	comF family protein; Region: comF; TIGR00201
639282006356	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
639282006357	active site
639282006358	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
639282006359	phosphoglyceromutase; Provisional; Region: PRK05434
639282006360	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
639282006361	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
639282006362	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
639282006363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282006364	S-adenosylmethionine binding site [chemical binding]; other site
639282006365	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
639282006366	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
639282006367	active site
639282006368	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
639282006369	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
639282006370	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
639282006371	Domain of unknown function (DUF377); Region: DUF377; pfam04041
639282006372	active site
639282006373	Domain of unknown function (DUF4213); Region: DUF4213; pfam13938
639282006374	Domain of unknown function (DUF364); Region: DUF364; pfam04016
639282006375	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
639282006376	metal binding site [ion binding]; metal-binding site
639282006377	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
639282006378	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
639282006379	substrate binding site [chemical binding]; other site
639282006380	glutamase interaction surface [polypeptide binding]; other site
639282006381	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
639282006382	HIT family signature motif; other site
639282006383	catalytic residue [active]
639282006384	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
639282006385	Protein export membrane protein; Region: SecD_SecF; cl14618
639282006386	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
639282006387	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
639282006388	HlyD family secretion protein; Region: HlyD_3; pfam13437
639282006389	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
639282006390	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
639282006391	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
639282006392	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
639282006393	UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179
639282006394	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
639282006395	NAD binding site [chemical binding]; other site
639282006396	homodimer interface [polypeptide binding]; other site
639282006397	active site
639282006398	substrate binding site [chemical binding]; other site
639282006399	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
639282006400	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
639282006401	catalytic loop [active]
639282006402	iron binding site [ion binding]; other site
639282006403	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
639282006404	FAD binding pocket [chemical binding]; other site
639282006405	FAD binding motif [chemical binding]; other site
639282006406	phosphate binding motif [ion binding]; other site
639282006407	beta-alpha-beta structure motif; other site
639282006408	NAD binding pocket [chemical binding]; other site
639282006409	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
639282006410	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
639282006411	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
639282006412	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
639282006413	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
639282006414	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
639282006415	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
639282006416	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
639282006417	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
639282006418	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
639282006419	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
639282006420	NAD(P) binding site [chemical binding]; other site
639282006421	catalytic residues [active]
639282006422	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
639282006423	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
639282006424	putative active site [active]
639282006425	putative CoA binding site [chemical binding]; other site
639282006426	nudix motif; other site
639282006427	metal binding site [ion binding]; metal-binding site
639282006428	Uncharacterized conserved protein [Function unknown]; Region: COG3937
639282006429	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
639282006430	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
639282006431	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
639282006432	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
639282006433	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
639282006434	DNA binding residues [nucleotide binding]
639282006435	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
639282006436	Clp amino terminal domain; Region: Clp_N; pfam02861
639282006437	Clp amino terminal domain; Region: Clp_N; pfam02861
639282006438	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282006439	Walker A motif; other site
639282006440	ATP binding site [chemical binding]; other site
639282006441	Walker B motif; other site
639282006442	arginine finger; other site
639282006443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282006444	Walker A motif; other site
639282006445	ATP binding site [chemical binding]; other site
639282006446	Walker B motif; other site
639282006447	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
639282006448	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
639282006449	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
639282006450	DNA binding residues [nucleotide binding]
639282006451	putative dimer interface [polypeptide binding]; other site
639282006452	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
639282006453	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
639282006454	HSP70 interaction site [polypeptide binding]; other site
639282006455	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
639282006456	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
639282006457	dimer interface [polypeptide binding]; other site
639282006458	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
639282006459	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
639282006460	putative dimer interface [polypeptide binding]; other site
639282006461	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
639282006462	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
639282006463	active site
639282006464	exopolyphosphatase; Region: exo_poly_only; TIGR03706
639282006465	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
639282006466	Transposase; Region: HTH_Tnp_IS630; pfam01710
639282006467	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
639282006468	putative alcohol dehydrogenase; Provisional; Region: PRK13771
639282006469	putative NAD(P) binding site [chemical binding]; other site
639282006470	putative substrate binding site [chemical binding]; other site
639282006471	catalytic Zn binding site [ion binding]; other site
639282006472	structural Zn binding site [ion binding]; other site
639282006473	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
639282006474	putative active site pocket [active]
639282006475	dimerization interface [polypeptide binding]; other site
639282006476	putative catalytic residue [active]
639282006477	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
639282006478	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
639282006479	GatB domain; Region: GatB_Yqey; smart00845
639282006480	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
639282006481	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
639282006482	dimer interface [polypeptide binding]; other site
639282006483	substrate binding site [chemical binding]; other site
639282006484	metal binding site [ion binding]; metal-binding site
639282006485	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
639282006486	active site clefts [active]
639282006487	zinc binding site [ion binding]; other site
639282006488	dimer interface [polypeptide binding]; other site
639282006489	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
639282006490	active site residue [active]
639282006491	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
639282006492	active site residue [active]
639282006493	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
639282006494	active site residue [active]
639282006495	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
639282006496	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
639282006497	ABC-ATPase subunit  interface; other site
639282006498	dimer interface [polypeptide binding]; other site
639282006499	putative PBP binding regions; other site
639282006500	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
639282006501	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
639282006502	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
639282006503	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
639282006504	intersubunit interface [polypeptide binding]; other site
639282006505	nickel responsive regulator; Provisional; Region: PRK04460
639282006506	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
639282006507	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
639282006508	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
639282006509	catalytic residues [active]
639282006510	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
639282006511	molybdopterin cofactor binding site; other site
639282006512	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
639282006513	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
639282006514	molybdopterin cofactor binding site; other site
639282006515	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
639282006516	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
639282006517	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
639282006518	catalytic residue [active]
639282006519	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
639282006520	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
639282006521	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
639282006522	Ligand Binding Site [chemical binding]; other site
639282006523	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
639282006524	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
639282006525	Substrate binding site; other site
639282006526	Mg++ binding site; other site
639282006527	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
639282006528	active site
639282006529	substrate binding site [chemical binding]; other site
639282006530	CoA binding site [chemical binding]; other site
639282006531	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
639282006532	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
639282006533	glutaminase active site [active]
639282006534	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
639282006535	dimer interface [polypeptide binding]; other site
639282006536	active site
639282006537	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
639282006538	dimer interface [polypeptide binding]; other site
639282006539	active site
639282006540	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
639282006541	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
639282006542	Cl- selectivity filter; other site
639282006543	Cl- binding residues [ion binding]; other site
639282006544	pore gating glutamate residue; other site
639282006545	dimer interface [polypeptide binding]; other site
639282006546	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
639282006547	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
639282006548	AAA domain; Region: AAA_30; pfam13604
639282006549	AAA domain; Region: AAA_12; pfam13087
639282006550	Family description; Region: UvrD_C_2; pfam13538
639282006551	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
639282006552	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
639282006553	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
639282006554	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
639282006555	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
639282006556	active site
639282006557	Riboflavin kinase; Region: Flavokinase; pfam01687
639282006558	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
639282006559	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
639282006560	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282006561	FeS/SAM binding site; other site
639282006562	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
639282006563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282006564	binding surface
639282006565	Tetratricopeptide repeat; Region: TPR_16; pfam13432
639282006566	TPR motif; other site
639282006567	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
639282006568	Tetratricopeptide repeat; Region: TPR_16; pfam13432
639282006569	binding surface
639282006570	TPR motif; other site
639282006571	seryl-tRNA synthetase; Provisional; Region: PRK05431
639282006572	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
639282006573	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
639282006574	dimer interface [polypeptide binding]; other site
639282006575	active site
639282006576	motif 1; other site
639282006577	motif 2; other site
639282006578	motif 3; other site
639282006579	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
639282006580	active site
639282006581	homodimer interface [polypeptide binding]; other site
639282006582	SAM binding site [chemical binding]; other site
639282006583	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
639282006584	MOFRL family; Region: MOFRL; pfam05161
639282006585	Protein of unknown function, DUF606; Region: DUF606; pfam04657
639282006586	Peptidase family M48; Region: Peptidase_M48; pfam01435
639282006587	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
639282006588	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
639282006589	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
639282006590	PAS domain; Region: PAS_9; pfam13426
639282006591	putative active site [active]
639282006592	heme pocket [chemical binding]; other site
639282006593	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
639282006594	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282006595	dimer interface [polypeptide binding]; other site
639282006596	phosphorylation site [posttranslational modification]
639282006597	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282006598	ATP binding site [chemical binding]; other site
639282006599	Mg2+ binding site [ion binding]; other site
639282006600	G-X-G motif; other site
639282006601	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
639282006602	histidinol dehydrogenase; Region: hisD; TIGR00069
639282006603	NAD binding site [chemical binding]; other site
639282006604	dimerization interface [polypeptide binding]; other site
639282006605	product binding site; other site
639282006606	substrate binding site [chemical binding]; other site
639282006607	zinc binding site [ion binding]; other site
639282006608	catalytic residues [active]
639282006609	GAF domain; Region: GAF_2; pfam13185
639282006610	GAF domain; Region: GAF_3; pfam13492
639282006611	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282006612	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282006613	metal binding site [ion binding]; metal-binding site
639282006614	active site
639282006615	I-site; other site
639282006616	DNA polymerase I; Provisional; Region: PRK05755
639282006617	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
639282006618	active site
639282006619	metal binding site 1 [ion binding]; metal-binding site
639282006620	putative 5' ssDNA interaction site; other site
639282006621	metal binding site 3; metal-binding site
639282006622	metal binding site 2 [ion binding]; metal-binding site
639282006623	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
639282006624	putative DNA binding site [nucleotide binding]; other site
639282006625	putative metal binding site [ion binding]; other site
639282006626	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
639282006627	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
639282006628	active site
639282006629	DNA binding site [nucleotide binding]
639282006630	catalytic site [active]
639282006631	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
639282006632	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
639282006633	homodimer interface [polypeptide binding]; other site
639282006634	substrate-cofactor binding pocket; other site
639282006635	catalytic residue [active]
639282006636	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
639282006637	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
639282006638	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
639282006639	Late competence development protein ComFB; Region: ComFB; pfam10719
639282006640	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
639282006641	diiron binding motif [ion binding]; other site
639282006642	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
639282006643	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
639282006644	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
639282006645	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
639282006646	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
639282006647	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
639282006648	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
639282006649	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
639282006650	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
639282006651	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
639282006652	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
639282006653	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
639282006654	4Fe-4S binding domain; Region: Fer4; pfam00037
639282006655	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
639282006656	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
639282006657	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
639282006658	catalytic loop [active]
639282006659	iron binding site [ion binding]; other site
639282006660	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
639282006661	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
639282006662	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
639282006663	molybdopterin cofactor binding site; other site
639282006664	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
639282006665	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
639282006666	dimer interface [polypeptide binding]; other site
639282006667	[2Fe-2S] cluster binding site [ion binding]; other site
639282006668	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
639282006669	SLBB domain; Region: SLBB; pfam10531
639282006670	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
639282006671	4Fe-4S binding domain; Region: Fer4; pfam00037
639282006672	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
639282006673	4Fe-4S binding domain; Region: Fer4; pfam00037
639282006674	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
639282006675	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
639282006676	putative dimer interface [polypeptide binding]; other site
639282006677	[2Fe-2S] cluster binding site [ion binding]; other site
639282006678	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
639282006679	NADH dehydrogenase subunit D; Validated; Region: PRK06075
639282006680	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
639282006681	NADH dehydrogenase subunit B; Validated; Region: PRK06411
639282006682	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
639282006683	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
639282006684	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
639282006685	RNA binding surface [nucleotide binding]; other site
639282006686	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
639282006687	active site
639282006688	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
639282006689	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
639282006690	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
639282006691	dimer interface [polypeptide binding]; other site
639282006692	ssDNA binding site [nucleotide binding]; other site
639282006693	tetramer (dimer of dimers) interface [polypeptide binding]; other site
639282006694	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
639282006695	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
639282006696	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
639282006697	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
639282006698	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
639282006699	aspartate aminotransferase; Provisional; Region: PRK06290
639282006700	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
639282006701	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282006702	homodimer interface [polypeptide binding]; other site
639282006703	catalytic residue [active]
639282006704	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
639282006705	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
639282006706	putative active site [active]
639282006707	substrate binding site [chemical binding]; other site
639282006708	putative cosubstrate binding site; other site
639282006709	catalytic site [active]
639282006710	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
639282006711	substrate binding site [chemical binding]; other site
639282006712	Peptidase family M48; Region: Peptidase_M48; cl12018
639282006713	NusB family; Region: NusB; pfam01029
639282006714	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
639282006715	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282006716	S-adenosylmethionine binding site [chemical binding]; other site
639282006717	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
639282006718	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
639282006719	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
639282006720	catalytic residues [active]
639282006721	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
639282006722	thiS-thiF/thiG interaction site; other site
639282006723	ThiS-like ubiquitin; Region: ThiS-like; pfam14453
639282006724	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
639282006725	E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487
639282006726	putative ATP binding site [chemical binding]; other site
639282006727	putative substrate interface [chemical binding]; other site
639282006728	Competence protein; Region: Competence; pfam03772
639282006729	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
639282006730	Walker A motif; other site
639282006731	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
639282006732	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
639282006733	active site
639282006734	PHP Thumb interface [polypeptide binding]; other site
639282006735	metal binding site [ion binding]; metal-binding site
639282006736	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
639282006737	generic binding surface I; other site
639282006738	generic binding surface II; other site
639282006739	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
639282006740	dimer interface [polypeptide binding]; other site
639282006741	substrate binding site [chemical binding]; other site
639282006742	ATP binding site [chemical binding]; other site
639282006743	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
639282006744	heterotetramer interface [polypeptide binding]; other site
639282006745	active site pocket [active]
639282006746	cleavage site
639282006747	Domain of unknown function DUF20; Region: UPF0118; pfam01594
639282006748	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
639282006749	CheW-like domain; Region: CheW; pfam01584
639282006750	PAS domain; Region: PAS_10; pfam13596
639282006751	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
639282006752	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282006753	dimer interface [polypeptide binding]; other site
639282006754	putative CheW interface [polypeptide binding]; other site
639282006755	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
639282006756	putative binding surface; other site
639282006757	active site
639282006758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282006759	ATP binding site [chemical binding]; other site
639282006760	Mg2+ binding site [ion binding]; other site
639282006761	G-X-G motif; other site
639282006762	Response regulator receiver domain; Region: Response_reg; pfam00072
639282006763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282006764	active site
639282006765	phosphorylation site [posttranslational modification]
639282006766	intermolecular recognition site; other site
639282006767	dimerization interface [polypeptide binding]; other site
639282006768	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
639282006769	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282006770	active site
639282006771	phosphorylation site [posttranslational modification]
639282006772	intermolecular recognition site; other site
639282006773	dimerization interface [polypeptide binding]; other site
639282006774	CheB methylesterase; Region: CheB_methylest; pfam01339
639282006775	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
639282006776	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
639282006777	S-adenosylmethionine binding site [chemical binding]; other site
639282006778	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282006779	binding surface
639282006780	TPR motif; other site
639282006781	TPR repeat; Region: TPR_11; pfam13414
639282006782	Cupin domain; Region: Cupin_2; pfam07883
639282006783	Protein of unknown function DUF72; Region: DUF72; cl00777
639282006784	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
639282006785	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
639282006786	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
639282006787	NAD(P) binding site [chemical binding]; other site
639282006788	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
639282006789	Protein of unknown function DUF86; Region: DUF86; cl01031
639282006790	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
639282006791	active site
639282006792	NTP binding site [chemical binding]; other site
639282006793	metal binding triad [ion binding]; metal-binding site
639282006794	antibiotic binding site [chemical binding]; other site
639282006795	FlaG protein; Region: FlaG; pfam03646
639282006796	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
639282006797	flagellin; Reviewed; Region: PRK08869
639282006798	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
639282006799	AAA domain; Region: AAA_14; pfam13173
639282006800	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
639282006801	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
639282006802	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
639282006803	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
639282006804	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
639282006805	catalytic loop [active]
639282006806	iron binding site [ion binding]; other site
639282006807	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
639282006808	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
639282006809	Walker A/P-loop; other site
639282006810	ATP binding site [chemical binding]; other site
639282006811	Q-loop/lid; other site
639282006812	ABC transporter signature motif; other site
639282006813	Walker B; other site
639282006814	D-loop; other site
639282006815	H-loop/switch region; other site
639282006816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282006817	dimer interface [polypeptide binding]; other site
639282006818	conserved gate region; other site
639282006819	putative PBP binding loops; other site
639282006820	ABC-ATPase subunit interface; other site
639282006821	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
639282006822	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
639282006823	substrate binding pocket [chemical binding]; other site
639282006824	membrane-bound complex binding site; other site
639282006825	hinge residues; other site
639282006826	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
639282006827	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
639282006828	heme-binding residues [chemical binding]; other site
639282006829	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
639282006830	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282006831	FeS/SAM binding site; other site
639282006832	HemN C-terminal domain; Region: HemN_C; pfam06969
639282006833	WSC domain; Region: WSC; pfam01822
639282006834	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
639282006835	PAN domain; Region: PAN_4; pfam14295
639282006836	putative binding site; other site
639282006837	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
639282006838	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
639282006839	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
639282006840	Protein of unknown function DUF58; Region: DUF58; pfam01882
639282006841	MoxR-like ATPases [General function prediction only]; Region: COG0714
639282006842	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282006843	Walker A motif; other site
639282006844	ATP binding site [chemical binding]; other site
639282006845	Walker B motif; other site
639282006846	arginine finger; other site
639282006847	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
639282006848	intracellular protease, PfpI family; Region: PfpI; TIGR01382
639282006849	conserved cys residue [active]
639282006850	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
639282006851	Probable gene remnant. Similar to the C-terminal region of 2-hydroxyglutaryl-CoA dehydratase.
639282006852	Probable gene remnant. Similar to the C-terminal region of Wolinella succinogenes 2-hydroxyglutaryl-CoA dehydratase (247 aa) WS0738.
639282006853	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
639282006854	active site
639282006855	SAM binding site [chemical binding]; other site
639282006856	homodimer interface [polypeptide binding]; other site
639282006857	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
639282006858	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
639282006859	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
639282006860	active site
639282006861	SAM binding site [chemical binding]; other site
639282006862	homodimer interface [polypeptide binding]; other site
639282006863	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
639282006864	active site
639282006865	putative homodimer interface [polypeptide binding]; other site
639282006866	SAM binding site [chemical binding]; other site
639282006867	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
639282006868	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
639282006869	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
639282006870	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
639282006871	cobyric acid synthase; Provisional; Region: PRK00784
639282006872	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
639282006873	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
639282006874	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
639282006875	catalytic triad [active]
639282006876	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
639282006877	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
639282006878	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282006879	homodimer interface [polypeptide binding]; other site
639282006880	catalytic residue [active]
639282006881	cobalamin synthase; Reviewed; Region: cobS; PRK00235
639282006882	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
639282006883	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
639282006884	putative dimer interface [polypeptide binding]; other site
639282006885	active site pocket [active]
639282006886	putative cataytic base [active]
639282006887	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
639282006888	homotrimer interface [polypeptide binding]; other site
639282006889	Walker A motif; other site
639282006890	GTP binding site [chemical binding]; other site
639282006891	Walker B motif; other site
639282006892	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
639282006893	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
639282006894	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
639282006895	Precorrin-8X methylmutase; Region: CbiC; pfam02570
639282006896	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
639282006897	active site
639282006898	SAM binding site [chemical binding]; other site
639282006899	homodimer interface [polypeptide binding]; other site
639282006900	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
639282006901	active site
639282006902	SAM binding site [chemical binding]; other site
639282006903	homodimer interface [polypeptide binding]; other site
639282006904	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
639282006905	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
639282006906	intersubunit interface [polypeptide binding]; other site
639282006907	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
639282006908	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
639282006909	Walker A/P-loop; other site
639282006910	ATP binding site [chemical binding]; other site
639282006911	Q-loop/lid; other site
639282006912	ABC transporter signature motif; other site
639282006913	Walker B; other site
639282006914	D-loop; other site
639282006915	H-loop/switch region; other site
639282006916	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
639282006917	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
639282006918	dimer interface [polypeptide binding]; other site
639282006919	putative PBP binding regions; other site
639282006920	ABC-ATPase subunit  interface; other site
639282006921	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
639282006922	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
639282006923	active site
639282006924	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
639282006925	active site
639282006926	N-terminal domain interface [polypeptide binding]; other site
639282006927	Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797
639282006928	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
639282006929	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
639282006930	catalytic triad [active]
639282006931	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
639282006932	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282006933	Walker A/P-loop; other site
639282006934	ATP binding site [chemical binding]; other site
639282006935	Q-loop/lid; other site
639282006936	ABC transporter signature motif; other site
639282006937	Walker B; other site
639282006938	D-loop; other site
639282006939	H-loop/switch region; other site
639282006940	ABC-2 type transporter; Region: ABC2_membrane; cl17235
639282006941	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
639282006942	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
639282006943	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
639282006944	Walker A/P-loop; other site
639282006945	ATP binding site [chemical binding]; other site
639282006946	Q-loop/lid; other site
639282006947	ABC transporter signature motif; other site
639282006948	Walker B; other site
639282006949	D-loop; other site
639282006950	H-loop/switch region; other site
639282006951	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
639282006952	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
639282006953	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
639282006954	Walker A/P-loop; other site
639282006955	ATP binding site [chemical binding]; other site
639282006956	Q-loop/lid; other site
639282006957	ABC transporter signature motif; other site
639282006958	Walker B; other site
639282006959	D-loop; other site
639282006960	H-loop/switch region; other site
639282006961	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
639282006962	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
639282006963	dipeptide transporter; Provisional; Region: PRK10913
639282006964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282006965	dimer interface [polypeptide binding]; other site
639282006966	conserved gate region; other site
639282006967	putative PBP binding loops; other site
639282006968	ABC-ATPase subunit interface; other site
639282006969	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
639282006970	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282006971	dimer interface [polypeptide binding]; other site
639282006972	conserved gate region; other site
639282006973	putative PBP binding loops; other site
639282006974	ABC-ATPase subunit interface; other site
639282006975	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
639282006976	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
639282006977	peptide binding site [polypeptide binding]; other site
639282006978	prolyl-tRNA synthetase; Provisional; Region: PRK09194
639282006979	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
639282006980	dimer interface [polypeptide binding]; other site
639282006981	motif 1; other site
639282006982	active site
639282006983	motif 2; other site
639282006984	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
639282006985	putative deacylase active site [active]
639282006986	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
639282006987	active site
639282006988	motif 3; other site
639282006989	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
639282006990	anticodon binding site; other site
639282006991	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
639282006992	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
639282006993	DctM-like transporters; Region: DctM; pfam06808
639282006994	multifunctional aminopeptidase A; Provisional; Region: PRK00913
639282006995	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
639282006996	interface (dimer of trimers) [polypeptide binding]; other site
639282006997	Substrate-binding/catalytic site; other site
639282006998	Zn-binding sites [ion binding]; other site
639282006999	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
639282007000	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
639282007001	active site
639282007002	acyl-activating enzyme (AAE) consensus motif; other site
639282007003	putative CoA binding site [chemical binding]; other site
639282007004	AMP binding site [chemical binding]; other site
639282007005	LAO/AO transport system ATPase; Region: lao; TIGR00750
639282007006	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
639282007007	Walker A; other site
639282007008	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
639282007009	substrate binding site [chemical binding]; other site
639282007010	oxyanion hole (OAH) forming residues; other site
639282007011	trimer interface [polypeptide binding]; other site
639282007012	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
639282007013	B12 binding site [chemical binding]; other site
639282007014	cobalt ligand [ion binding]; other site
639282007015	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
639282007016	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
639282007017	substrate binding site [chemical binding]; other site
639282007018	oxyanion hole (OAH) forming residues; other site
639282007019	trimer interface [polypeptide binding]; other site
639282007020	Transcriptional regulator [Transcription]; Region: LysR; COG0583
639282007021	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
639282007022	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
639282007023	putative dimerization interface [polypeptide binding]; other site
639282007024	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
639282007025	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
639282007026	active site residue [active]
639282007027	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
639282007028	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
639282007029	Sporulation related domain; Region: SPOR; pfam05036
639282007030	Probable gene remnant. Similar to the N-terminal region of Desulfococcus oleovorans Hxd3 conserved hypothetical protein (288 aa).
639282007031	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
639282007032	PAS domain; Region: PAS_9; pfam13426
639282007033	putative active site [active]
639282007034	heme pocket [chemical binding]; other site
639282007035	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
639282007036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
639282007037	putative substrate translocation pore; other site
639282007038	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
639282007039	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
639282007040	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
639282007041	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
639282007042	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
639282007043	[4Fe-4S] binding site [ion binding]; other site
639282007044	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
639282007045	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
639282007046	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
639282007047	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
639282007048	molybdopterin cofactor binding site; other site
639282007049	Cytochrome c; Region: Cytochrom_C; pfam00034
639282007050	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
639282007051	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
639282007052	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
639282007053	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
639282007054	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
639282007055	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
639282007056	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
639282007057	tandem repeat interface [polypeptide binding]; other site
639282007058	oligomer interface [polypeptide binding]; other site
639282007059	active site residues [active]
639282007060	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
639282007061	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
639282007062	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
639282007063	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
639282007064	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
639282007065	RNA binding site [nucleotide binding]; other site
639282007066	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
639282007067	RNA binding site [nucleotide binding]; other site
639282007068	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
639282007069	RNA binding site [nucleotide binding]; other site
639282007070	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
639282007071	RNA binding site [nucleotide binding]; other site
639282007072	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
639282007073	RNA binding site [nucleotide binding]; other site
639282007074	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
639282007075	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
639282007076	cytidylate kinase; Provisional; Region: cmk; PRK00023
639282007077	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
639282007078	CMP-binding site; other site
639282007079	The sites determining sugar specificity; other site
639282007080	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
639282007081	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
639282007082	hinge; other site
639282007083	active site
639282007084	prephenate dehydrogenase; Validated; Region: PRK08507
639282007085	Prephenate dehydrogenase; Region: PDH; pfam02153
639282007086	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
639282007087	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
639282007088	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
639282007089	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
639282007090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282007091	homodimer interface [polypeptide binding]; other site
639282007092	catalytic residue [active]
639282007093	Chorismate mutase type II; Region: CM_2; pfam01817
639282007094	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
639282007095	Prephenate dehydratase; Region: PDT; pfam00800
639282007096	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
639282007097	putative L-Phe binding site [chemical binding]; other site
639282007098	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
639282007099	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
639282007100	dimer interface [polypeptide binding]; other site
639282007101	active site
639282007102	glycine loop; other site
639282007103	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
639282007104	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
639282007105	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
639282007106	DNA-binding site [nucleotide binding]; DNA binding site
639282007107	FCD domain; Region: FCD; pfam07729
639282007108	Transcriptional regulator [Transcription]; Region: IclR; COG1414
639282007109	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
639282007110	Bacterial transcriptional regulator; Region: IclR; pfam01614
639282007111	putative GTP cyclohydrolase; Provisional; Region: PRK13674
639282007112	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282007113	TPR motif; other site
639282007114	binding surface
639282007115	argininosuccinate lyase; Provisional; Region: PRK00855
639282007116	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
639282007117	active sites [active]
639282007118	tetramer interface [polypeptide binding]; other site
639282007119	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
639282007120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282007121	active site
639282007122	phosphorylation site [posttranslational modification]
639282007123	intermolecular recognition site; other site
639282007124	dimerization interface [polypeptide binding]; other site
639282007125	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282007126	Walker A motif; other site
639282007127	ATP binding site [chemical binding]; other site
639282007128	Walker B motif; other site
639282007129	arginine finger; other site
639282007130	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
639282007131	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
639282007132	dimer interface [polypeptide binding]; other site
639282007133	phosphorylation site [posttranslational modification]
639282007134	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282007135	ATP binding site [chemical binding]; other site
639282007136	Mg2+ binding site [ion binding]; other site
639282007137	G-X-G motif; other site
639282007138	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
639282007139	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
639282007140	HSP70 interaction site [polypeptide binding]; other site
639282007141	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
639282007142	substrate binding site [polypeptide binding]; other site
639282007143	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
639282007144	Zn binding sites [ion binding]; other site
639282007145	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
639282007146	dimer interface [polypeptide binding]; other site
639282007147	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
639282007148	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
639282007149	nucleotide binding site [chemical binding]; other site
639282007150	NEF interaction site [polypeptide binding]; other site
639282007151	SBD interface [polypeptide binding]; other site
639282007152	GrpE; Region: GrpE; pfam01025
639282007153	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
639282007154	dimer interface [polypeptide binding]; other site
639282007155	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
639282007156	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
639282007157	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
639282007158	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
639282007159	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
639282007160	putative DNA binding site [nucleotide binding]; other site
639282007161	putative Zn2+ binding site [ion binding]; other site
639282007162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
639282007163	ATP binding site [chemical binding]; other site
639282007164	Mg2+ binding site [ion binding]; other site
639282007165	G-X-G motif; other site
639282007166	Probable gene remnant. Similar to the C-terminal region of Psychroflexus torquis ATCC 700755 tyrosine recombinase (291 aa) P700755_13527.
639282007167	Probable gene remnant. Similar to the C-terminal region of tyrosine recombinase
639282007168	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
639282007169	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
639282007170	GDP-binding site [chemical binding]; other site
639282007171	ACT binding site; other site
639282007172	IMP binding site; other site
639282007173	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
639282007174	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
639282007175	dimer interface [polypeptide binding]; other site
639282007176	motif 1; other site
639282007177	active site
639282007178	motif 2; other site
639282007179	motif 3; other site
639282007180	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
639282007181	homodimer interface [polypeptide binding]; other site
639282007182	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282007183	catalytic residue [active]
639282007184	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
639282007185	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
639282007186	substrate binding site [chemical binding]; other site
639282007187	hexamer interface [polypeptide binding]; other site
639282007188	metal binding site [ion binding]; metal-binding site
639282007189	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
639282007190	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
639282007191	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
639282007192	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
639282007193	nudix motif; other site
639282007194	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
639282007195	Clp amino terminal domain; Region: Clp_N; pfam02861
639282007196	Clp amino terminal domain; Region: Clp_N; pfam02861
639282007197	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282007198	Walker A motif; other site
639282007199	ATP binding site [chemical binding]; other site
639282007200	Walker B motif; other site
639282007201	arginine finger; other site
639282007202	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282007203	Walker A motif; other site
639282007204	ATP binding site [chemical binding]; other site
639282007205	Walker B motif; other site
639282007206	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
639282007207	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
639282007208	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
639282007209	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
639282007210	Zn2+ binding site [ion binding]; other site
639282007211	Mg2+ binding site [ion binding]; other site
639282007212	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
639282007213	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
639282007214	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
639282007215	active site
639282007216	catalytic residues [active]
639282007217	metal binding site [ion binding]; metal-binding site
639282007218	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
639282007219	glyoxylate reductase; Reviewed; Region: PRK13243
639282007220	dimerization interface [polypeptide binding]; other site
639282007221	ligand binding site [chemical binding]; other site
639282007222	NADP binding site [chemical binding]; other site
639282007223	catalytic site [active]
639282007224	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
639282007225	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
639282007226	dimer interface [polypeptide binding]; other site
639282007227	phosphorylation site [posttranslational modification]
639282007228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282007229	ATP binding site [chemical binding]; other site
639282007230	Mg2+ binding site [ion binding]; other site
639282007231	G-X-G motif; other site
639282007232	Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391
639282007233	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
639282007234	metal binding triad; other site
639282007235	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
639282007236	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
639282007237	metal binding triad; other site
639282007238	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
639282007239	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
639282007240	active site
639282007241	pyrophosphate binding site [ion binding]; other site
639282007242	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
639282007243	domain_subunit interface; other site
639282007244	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
639282007245	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
639282007246	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
639282007247	NAD(P) binding site [chemical binding]; other site
639282007248	4Fe-4S binding domain; Region: Fer4; pfam00037
639282007249	4Fe-4S binding domain; Region: Fer4_6; pfam12837
639282007250	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
639282007251	4Fe-4S binding domain; Region: Fer4; pfam00037
639282007252	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
639282007253	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
639282007254	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
639282007255	active site
639282007256	FMN binding site [chemical binding]; other site
639282007257	substrate binding site [chemical binding]; other site
639282007258	3Fe-4S cluster binding site [ion binding]; other site
639282007259	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
639282007260	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
639282007261	putative active site [active]
639282007262	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
639282007263	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
639282007264	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
639282007265	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282007266	FeS/SAM binding site; other site
639282007267	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
639282007268	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
639282007269	FliW protein; Region: FliW; cl00740
639282007270	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
639282007271	Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256
639282007272	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
639282007273	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
639282007274	FlgN protein; Region: FlgN; pfam05130
639282007275	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
639282007276	Rod binding protein; Region: Rod-binding; cl01626
639282007277	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
639282007278	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
639282007279	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696
639282007280	Flagellar L-ring protein; Region: FlgH; pfam02107
639282007281	SAF-like; Region: SAF_2; pfam13144
639282007282	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
639282007283	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
639282007284	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
639282007285	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
639282007286	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
639282007287	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
639282007288	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
639282007289	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
639282007290	active site
639282007291	HslU subunit interaction site [polypeptide binding]; other site
639282007292	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
639282007293	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282007294	Walker A motif; other site
639282007295	ATP binding site [chemical binding]; other site
639282007296	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
639282007297	Walker B motif; other site
639282007298	arginine finger; other site
639282007299	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
639282007300	hypothetical protein; Provisional; Region: PRK08960
639282007301	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
639282007302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282007303	homodimer interface [polypeptide binding]; other site
639282007304	catalytic residue [active]
639282007305	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
639282007306	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
639282007307	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
639282007308	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
639282007309	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
639282007310	transmembrane helices; other site
639282007311	Predicted permease; Region: DUF318; cl17795
639282007312	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
639282007313	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
639282007314	substrate-cofactor binding pocket; other site
639282007315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282007316	catalytic residue [active]
639282007317	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
639282007318	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
639282007319	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
639282007320	catalytic residue [active]
639282007321	Predicted transcriptional regulator [Transcription]; Region: COG1959
639282007322	Transcriptional regulator; Region: Rrf2; cl17282
639282007323	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
639282007324	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
639282007325	trimer interface [polypeptide binding]; other site
639282007326	active site
639282007327	substrate binding site [chemical binding]; other site
639282007328	CoA binding site [chemical binding]; other site
639282007329	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
639282007330	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
639282007331	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
639282007332	dimer interface [polypeptide binding]; other site
639282007333	ADP-ribose binding site [chemical binding]; other site
639282007334	active site
639282007335	nudix motif; other site
639282007336	metal binding site [ion binding]; metal-binding site
639282007337	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
639282007338	MutS domain I; Region: MutS_I; pfam01624
639282007339	MutS domain II; Region: MutS_II; pfam05188
639282007340	MutS domain III; Region: MutS_III; pfam05192
639282007341	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
639282007342	Walker A/P-loop; other site
639282007343	ATP binding site [chemical binding]; other site
639282007344	Q-loop/lid; other site
639282007345	ABC transporter signature motif; other site
639282007346	Walker B; other site
639282007347	D-loop; other site
639282007348	H-loop/switch region; other site
639282007349	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
639282007350	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
639282007351	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
639282007352	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
639282007353	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
639282007354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
639282007355	dimer interface [polypeptide binding]; other site
639282007356	conserved gate region; other site
639282007357	putative PBP binding loops; other site
639282007358	ABC-ATPase subunit interface; other site
639282007359	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
639282007360	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282007361	Walker A/P-loop; other site
639282007362	ATP binding site [chemical binding]; other site
639282007363	Q-loop/lid; other site
639282007364	ABC transporter signature motif; other site
639282007365	Walker B; other site
639282007366	D-loop; other site
639282007367	H-loop/switch region; other site
639282007368	TOBE domain; Region: TOBE_2; pfam08402
639282007369	molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168
639282007370	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
639282007371	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
639282007372	DnaA N-terminal domain; Region: DnaA_N; pfam11638
639282007373	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282007374	Walker A motif; other site
639282007375	ATP binding site [chemical binding]; other site
639282007376	Walker B motif; other site
639282007377	arginine finger; other site
639282007378	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
639282007379	DnaA box-binding interface [nucleotide binding]; other site
639282007380	threonine dehydratase; Provisional; Region: PRK08198
639282007381	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
639282007382	tetramer interface [polypeptide binding]; other site
639282007383	pyridoxal 5'-phosphate binding site [chemical binding]; other site
639282007384	catalytic residue [active]
639282007385	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
639282007386	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
639282007387	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
639282007388	putative NAD(P) binding site [chemical binding]; other site
639282007389	putative active site [active]
639282007390	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007391	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007392	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007393	Probable transposase; Region: OrfB_IS605; pfam01385
639282007394	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007395	Probable gene remnant. Similar to the C-terminal region of hypothetical protein.
639282007396	Late competence development protein ComFB; Region: ComFB; pfam10719
639282007397	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
639282007398	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
639282007399	active site
639282007400	interdomain interaction site; other site
639282007401	putative metal-binding site [ion binding]; other site
639282007402	nucleotide binding site [chemical binding]; other site
639282007403	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
639282007404	domain I; other site
639282007405	DNA binding groove [nucleotide binding]
639282007406	phosphate binding site [ion binding]; other site
639282007407	domain II; other site
639282007408	domain III; other site
639282007409	nucleotide binding site [chemical binding]; other site
639282007410	catalytic site [active]
639282007411	domain IV; other site
639282007412	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
639282007413	TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028
639282007414	active site
639282007415	interdomain interaction site; other site
639282007416	putative metal-binding site [ion binding]; other site
639282007417	nucleotide binding site [chemical binding]; other site
639282007418	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
639282007419	DNA topoisomerase; Region: Topoisom_bac; pfam01131
639282007420	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
639282007421	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
639282007422	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
639282007423	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
639282007424	Type II/IV secretion system protein; Region: T2SE; pfam00437
639282007425	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
639282007426	Walker A motif; other site
639282007427	ATP binding site [chemical binding]; other site
639282007428	Walker B motif; other site
639282007429	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
639282007430	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
639282007431	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
639282007432	AAA-like domain; Region: AAA_10; pfam12846
639282007433	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
639282007434	PilZ domain; Region: PilZ; pfam07238
639282007435	AAA-like domain; Region: AAA_10; pfam12846
639282007436	EcsC protein family; Region: EcsC; pfam12787
639282007437	Probable gene remnant. Similar to the C-terminal region of Neisseria meningitidis serogroup C transposase for IS1106A3 (335 aa) NMC1775.
639282007438	Pseudogene. Similar to the C-terminal region of transposase
639282007439	UvsW helicase; Provisional; Region: uvsW; PHA02558
639282007440	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
639282007441	nucleotide binding region [chemical binding]; other site
639282007442	ATP-binding site [chemical binding]; other site
639282007443	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007444	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007445	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007446	Probable transposase; Region: OrfB_IS605; pfam01385
639282007447	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007448	Probable gene remnant. Similar to the C-terminal region of hypothetical protein.
639282007449	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007450	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007451	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007452	Probable transposase; Region: OrfB_IS605; pfam01385
639282007453	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007454	Probable gene remnant. Similar to the C-terminal region of hypothetical protein.
639282007455	endonuclease subunit; Provisional; Region: 47; PHA02546
639282007456	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
639282007457	active site
639282007458	metal binding site [ion binding]; metal-binding site
639282007459	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
639282007460	Walker A/P-loop; other site
639282007461	ATP binding site [chemical binding]; other site
639282007462	endonuclease subunit; Provisional; Region: 46; PHA02562
639282007463	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007464	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007465	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007466	Probable transposase; Region: OrfB_IS605; pfam01385
639282007467	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007468	Probable gene remnant. Similar to the C-terminal region of hypothetical protein.
639282007469	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007470	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007471	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007472	Probable transposase; Region: OrfB_IS605; pfam01385
639282007473	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007474	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
639282007475	Walker A motif; other site
639282007476	ATP binding site [chemical binding]; other site
639282007477	Walker B motif; other site
639282007478	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
639282007479	trimer interface [polypeptide binding]; other site
639282007480	active site
639282007481	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
639282007482	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
639282007483	catalytic residues [active]
639282007484	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
639282007485	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
639282007486	putative active site [active]
639282007487	PhoH-like protein; Region: PhoH; pfam02562
639282007488	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
639282007489	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282007490	dimer interface [polypeptide binding]; other site
639282007491	putative CheW interface [polypeptide binding]; other site
639282007492	Hemerythrin; Region: Hemerythrin; cd12107
639282007493	Fe binding site [ion binding]; other site
639282007494	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
639282007495	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
639282007496	active site
639282007497	DNA binding site [nucleotide binding]
639282007498	Int/Topo IB signature motif; other site
639282007499	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
639282007500	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
639282007501	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
639282007502	CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592
639282007503	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
639282007504	Family of unknown function (DUF694); Region: DUF694; pfam05107
639282007505	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
639282007506	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
639282007507	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
639282007508	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007509	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007510	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007511	Probable transposase; Region: OrfB_IS605; pfam01385
639282007512	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007513	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007514	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007515	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007516	Probable transposase; Region: OrfB_IS605; pfam01385
639282007517	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007518	Probable gene remnant. Similar to the C-terminal region of Plasmodium vivax (strain Belem) Reticulocyte-binding protein 2 precursor (2867 aa) RBP-2.
639282007519	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
639282007520	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
639282007521	active site
639282007522	metal binding site [ion binding]; metal-binding site
639282007523	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007524	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007525	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007526	Probable transposase; Region: OrfB_IS605; pfam01385
639282007527	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007528	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
639282007529	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
639282007530	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
639282007531	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
639282007532	DNA binding residues [nucleotide binding]
639282007533	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007534	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007535	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007536	Probable transposase; Region: OrfB_IS605; pfam01385
639282007537	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007538	Staphylococcal nuclease homologues; Region: SNc; smart00318
639282007539	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
639282007540	Catalytic site; other site
639282007541	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282007542	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
639282007543	Walker A motif; other site
639282007544	ATP binding site [chemical binding]; other site
639282007545	Walker B motif; other site
639282007546	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007547	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007548	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007549	Probable transposase; Region: OrfB_IS605; pfam01385
639282007550	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007551	Probable gene remnant. Similar to the C-terminal region of hypothetical protein.
639282007552	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
639282007553	Transposase, Mutator family; Region: Transposase_mut; pfam00872
639282007554	MULE transposase domain; Region: MULE; pfam10551
639282007555	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007556	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007557	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007558	Probable transposase; Region: OrfB_IS605; pfam01385
639282007559	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007560	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
639282007561	hypothetical protein; Provisional; Region: nrdC.11; PHA02603
639282007562	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
639282007563	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
639282007564	non-specific DNA binding site [nucleotide binding]; other site
639282007565	salt bridge; other site
639282007566	sequence-specific DNA binding site [nucleotide binding]; other site
639282007567	HipA N-terminal domain; Region: Couple_hipA; cl11853
639282007568	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
639282007569	HipA-like N-terminal domain; Region: HipA_N; pfam07805
639282007570	HipA-like C-terminal domain; Region: HipA_C; pfam07804
639282007571	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
639282007572	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007573	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007574	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007575	Probable transposase; Region: OrfB_IS605; pfam01385
639282007576	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007577	Probable gene remnant. Similar to the N-terminal region of Helicobacter hepaticus conserved hypothetical protein (632 aa) HH_1039.
639282007578	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
639282007579	DNA methylase; Region: N6_N4_Mtase; cl17433
639282007580	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
639282007581	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
639282007582	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007583	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007585	Probable transposase; Region: OrfB_IS605; pfam01385
639282007586	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007587	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282007588	FeS/SAM binding site; other site
639282007589	Late competence development protein ComFB; Region: ComFB; pfam10719
639282007590	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007591	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007592	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007593	Probable transposase; Region: OrfB_IS605; pfam01385
639282007594	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007595	Probable gene remnant. Similar to the C-terminal region of Pelobacter propionicus (strain DSM 2379) ATPase (686 aa) Ppro_3804.
639282007596	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
639282007597	catalytic triad [active]
639282007598	putative active site [active]
639282007599	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282007600	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282007601	metal binding site [ion binding]; metal-binding site
639282007602	active site
639282007603	I-site; other site
639282007604	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
639282007605	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282007606	dimerization interface [polypeptide binding]; other site
639282007607	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
639282007608	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282007609	dimer interface [polypeptide binding]; other site
639282007610	putative CheW interface [polypeptide binding]; other site
639282007611	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
639282007612	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
639282007613	dimerization interface [polypeptide binding]; other site
639282007614	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
639282007615	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
639282007616	dimer interface [polypeptide binding]; other site
639282007617	putative CheW interface [polypeptide binding]; other site
639282007618	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007619	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007620	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007621	Probable transposase; Region: OrfB_IS605; pfam01385
639282007622	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007623	Helix-turn-helix domain; Region: HTH_17; pfam12728
639282007624	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
639282007625	anti sigma factor interaction site; other site
639282007626	regulatory phosphorylation site [posttranslational modification]; other site
639282007627	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
639282007628	putative CheA interaction surface; other site
639282007629	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
639282007630	Response regulator receiver domain; Region: Response_reg; pfam00072
639282007631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282007632	active site
639282007633	phosphorylation site [posttranslational modification]
639282007634	intermolecular recognition site; other site
639282007635	dimerization interface [polypeptide binding]; other site
639282007636	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
639282007637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282007638	active site
639282007639	phosphorylation site [posttranslational modification]
639282007640	intermolecular recognition site; other site
639282007641	dimerization interface [polypeptide binding]; other site
639282007642	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
639282007643	putative binding surface; other site
639282007644	active site
639282007645	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
639282007646	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
639282007647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282007648	ATP binding site [chemical binding]; other site
639282007649	Mg2+ binding site [ion binding]; other site
639282007650	G-X-G motif; other site
639282007651	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
639282007652	Response regulator receiver domain; Region: Response_reg; pfam00072
639282007653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
639282007654	active site
639282007655	phosphorylation site [posttranslational modification]
639282007656	intermolecular recognition site; other site
639282007657	dimerization interface [polypeptide binding]; other site
639282007658	Uncharacterized conserved protein [Function unknown]; Region: COG3339
639282007659	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
639282007660	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
639282007661	metal binding site [ion binding]; metal-binding site
639282007662	active site
639282007663	I-site; other site
639282007664	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007665	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007666	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007667	Probable transposase; Region: OrfB_IS605; pfam01385
639282007668	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007669	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
639282007670	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
639282007671	ATP binding site [chemical binding]; other site
639282007672	Mg2+ binding site [ion binding]; other site
639282007673	G-X-G motif; other site
639282007674	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
639282007675	anchoring element; other site
639282007676	dimer interface [polypeptide binding]; other site
639282007677	ATP binding site [chemical binding]; other site
639282007678	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
639282007679	active site
639282007680	metal binding site [ion binding]; metal-binding site
639282007681	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
639282007682	CHC2 zinc finger; Region: zf-CHC2; cl17510
639282007683	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
639282007684	DNA gyrase subunit A; Validated; Region: PRK05560
639282007685	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
639282007686	CAP-like domain; other site
639282007687	active site
639282007688	primary dimer interface [polypeptide binding]; other site
639282007689	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
639282007690	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
639282007691	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
639282007692	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
639282007693	Transposase IS200 like; Region: Y1_Tnp; pfam01797
639282007694	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
639282007695	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
639282007696	Probable transposase; Region: OrfB_IS605; pfam01385
639282007697	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
639282007698	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
639282007699	Initiator Replication protein; Region: Rep_3; cl17676
639282007700	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
639282007701	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
639282007702	Walker A motif; other site
639282007703	ATP binding site [chemical binding]; other site
639282007704	Walker B motif; other site
639282007705	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
639282007706	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
639282007707	P-loop; other site
639282007708	Magnesium ion binding site [ion binding]; other site
639282007709	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
639282007710	Magnesium ion binding site [ion binding]; other site
639282007711	ParB-like nuclease domain; Region: ParB; smart00470
639282007712	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
639282007713	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
639282007714	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
639282007715	active site
639282007716	effector binding site; other site
639282007717	dimer interface [polypeptide binding]; other site
639282007718	TSCPD domain; Region: TSCPD; pfam12637
639282007719	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
639282007720	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
639282007721	Walker A motif; other site
639282007722	ATP binding site [chemical binding]; other site
639282007723	Walker B motif; other site
639282007724	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
639282007725	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
639282007726	DHH family; Region: DHH; pfam01368
639282007727	DHHA1 domain; Region: DHHA1; pfam02272
639282007728	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
639282007729	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
639282007730	IHF - DNA interface [nucleotide binding]; other site
639282007731	IHF dimer interface [polypeptide binding]; other site
639282007732	plasmid segregation protein ParM; Provisional; Region: PRK13917
639282007733	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
639282007734	Mg binding site [ion binding]; other site
639282007735	nucleotide binding site [chemical binding]; other site
639282007736	putative protofilament interface [polypeptide binding]; other site
639282007737	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
639282007738	binding surface
639282007739	TPR motif; other site
639282007740	TPR repeat; Region: TPR_11; pfam13414
639282007741	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176
639282007742	linker region; other site
639282007743	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
639282007744	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
639282007745	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282007746	FeS/SAM binding site; other site
639282007747	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
639282007748	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
639282007749	FeS/SAM binding site; other site
639282007750	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
639282007751	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
639282007752	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
639282007753	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
639282007754	active site
639282007755	substrate binding site [chemical binding]; other site
639282007756	catalytic site [active]
639282007757	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
639282007758	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
639282007759	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
639282007760	active site
639282007761	catalytic site [active]
639282007762	substrate binding site [chemical binding]; other site
639282007763	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
639282007764	active site
639282007765	DNA binding site [nucleotide binding]
639282007766	catalytic site [active]